TY 2010 Form 990

Do not include amounts reported on lines 6b, 7b, 8b, 9b, and 10b of Part VIII.	(A) Total expenses	(B) Program service expenses	(C) Management and general expenses	(D) Fundraising expenses
1	Grants and other assistance to governments and organizations in the U.S. See Part IV, line 21	0
2	Grants and other assistance to individuals in the U.S. See Part IV, line 22	1,372,750	1,372,750
3	Grants and other assistance to governments, organizations, and individuals outside the U.S. See Part IV, lines 15 and 16	0
4	Benefits paid to or for members	0
5	Compensation of current officers, directors, trustees, and key employees ....	2,108,731	1,897,858	210,873
6	Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) ....	0
7	Other salaries and wages	17,524,787	15,772,308	1,752,479
8	Pension plan contributions (include section 401(k) and section 403(b) employer contributions) ....	2,521,621	2,269,459	252,162
9	Other employee benefits .......	2,895,379	2,605,841	289,538
10	Payroll taxes ...........	1,250,858	1,125,772	125,086
11	Fees for services (non-employees):
a	Management ......	0
b	Legal .........	67,048		67,048
c	Accounting ...........	10,200		10,200
d	Lobbying ...........	0
e	Professional fundraising. See Part IV, line 17..	0
f	Investment management fees ......	0
g	Other ..........	1,230,591	1,107,532	123,059
12	Advertising and promotion ....	0
13	Office expenses .......	253,218	227,896	25,322
14	Information technology ......	328,843	295,969	32,874
15	Royalties ..	-9,218	-8,296	-922
16	Occupancy ...........	2,136,596	1,922,936	213,660
17	Travel ............	544,396	489,956	54,440
18	Payments of travel or entertainment expenses for any federal, state, or local public officials ......	0
19	Conferences, conventions, and meetings ....	738,627	664,764	73,863
20	Interest ...........	0
21	Payments to affiliates .......	0
22	Depreciation, depletion, and amortization .....	14,255,082	12,829,574	1,425,508
23	Insurance ..............	0
24	Other expenses. Itemize expenses not covered above. (Expenses grouped together and labeled miscellaneous may not exceed 5% of total expenses shown on line 25 below.)
a	COST-SHARING WITH RELATED ORG	17,808,356	16,027,520	1,780,836
b	LAB SUPPLIES	6,401,805	5,761,625	640,180
c	NON-CAPITAL EQUIPMENT	674,078	606,670	67,408
d	SCIENTIFIC CONSULTING	225,771	203,194	22,577
e	COLLABORATION EXPENSE	135,829	122,246	13,583
f	All other expenses	217,849	196,064	21,785
25	Total functional expenses. Add lines 1 through 24f	72,693,197	65,491,638	7,201,559	0
26	Joint costs. Check here if following SOP 98-2 (ASC 958-720). Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation

Part X Balance Sheet
	1	Cashnon-interest-bearing ..........	3,699,012	1	2,178,335
2	Savings and temporary cash investments .......		2
3	Pledges and grants receivable, net .........	720,639	3	804,237
4	Accounts receivable, net .........		4
5	Receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
	Schedule L ..........		5
6	Receivables from other disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B). Complete Part II of
	Schedule L ..........		6
7	Notes and loans receivable, net .............		7
8	Inventories for sale or use ..............	398,012	8	349,600
9	Prepaid expenses and deferred charges ............	553,403	9	631,357
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	309,180,895
b	Less: accumulated depreciation. .....	10b	119,912,525	202,127,907	10c	189,268,370
11	Investments—publicly traded securities ..........	136,133,751	11	91,175,334
12	Investments—other securities. See Part IV, line 11 ......		12
13	Investments—program-related. See Part IV, line 11 ..		13
14	Intangible assets .........		14
15	Other assets. See Part IV, line 11 ...........	222,146,556	15	212,236,512
16	Total assets. Add lines 1 through 15 (must equal line 34)...	565,779,280	16	496,643,745
	17	Accounts payable and accrued expenses .	7,131,445	17	6,316,670
18	Grants payable ..........		18
19	Deferred revenue ..........		19
20	Tax-exempt bond liabilities ..........		20
21	Escrow or custodial account liability. Complete Part IV of Schedule D..		21
22	Payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
	persons. Complete Part II of Schedule L..........		22
23	Secured mortgages and notes payable to unrelated third parties ..		23
24	Unsecured notes and loans payable to unrelated third parties ....		24
25	Other liabilities. Complete Part X of Schedule D.....	220,373,182	25	211,148,145
26	Total liabilities. Add lines 17 through 25.....	227,504,627	26	217,464,815
		Organizations that follow SFAS 117, check here and complete lines 27 through 29, and lines 33 and 34.
27	Unrestricted net assets .....	338,274,653	27	279,178,930
28	Temporarily restricted net assets .....		28
29	Permanently restricted net assets .....		29
	Organizations that do not follow SFAS 117, check here and complete lines 30 through 34.
30	Capital stock or trust principal, or current funds .....		30
31	Paid-in or capital surplus, or land, building or equipment fund .....		31
32	Retained earnings, endowment, accumulated income, or other funds		32
33	Total net assets or fund balances .....	338,274,653	33	279,178,930
34	Total liabilities and net assets/fund balances .....	565,779,280	34	496,643,745

- TIN:

SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service

Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.

Attach to Form 990 or Form 990-EZ. right arrow

See separate instructions.

OMB No. 1545-0047

2010

Open to Public
Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Reason for Public Charity Status (All organizations must complete this part.) See instructions

The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)

A church, convention of churches, or association of churches. section 170(b)(1)(A)(i).

A school described in section 170(b)(1)(A)(ii). (Attach Schedule E.)

A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name, city, and state:

SEE ABOVE,

SEE ABOVE, MO

An organization operated for the benefit of a college or university owned or operated by a governmental unit described in

section 170(b)(1)(A)(iv). (Complete Part II.)

A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in

section 170(b)(1)(A)(vi). (Complete Part II.)

A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)

An organization that normally receives: (1) more than 331/3% of its support from contributions, membership fees, and gross

receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of

its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses

acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)

An organization organized and operated exclusively to test for public safety. Seesection 509(a)(4).

An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box that describes the type of supporting organization and complete lines 11e through 11h.

Type I

Type II

Type III - Functionally integrated

Type III - Other

By checking this box, I certify that the organization is not controlled directly or indirectly by one or more disqualified persons other than foundation managers and other than one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2).

If the organization received a written determination from the IRS that it is a Type I, Type II or Type III supporting organization, check this box ..................................................

Since August 17, 2006, has the organization accepted any gift or contribution from any of the
following persons?

(i) a person who directly or indirectly controls, either alone or together with persons described in (ii)

Yes

and (iii) below, the governing body of the the supported organization? ................

11g(i)

(ii) a family member of a person described in (i) above? ......................

11g(ii)

(iii) a 35% controlled entity of a person described in (i) or (ii) above? ................

11g(iii)

Provide the following information about the supported organization(s).

(i) Name of supported organization	(ii) EIN	(iv) Is the organization in col. (i) listed in your governing document?		(v) Did you notify the organization in col. (i) of your support?		(vi) Is the organization in col. (i) organized in the U.S.?		(vii) Amount of support?
(i) Name of supported organization	(ii) EIN	Yes	No	Yes	No	Yes	No	(vii) Amount of support?


Total

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 11285F

Schedule A (Form 990 or 990-EZ) 2010

Page 2

Part II

Support Schedule for Organizations Described in IRC 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year(or fiscal year beginning in)		(a) 2006	(b) 2007	(c) 2008	(d) 2009	(e) 2010	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....
2	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......
3	The value of services or facilities furnished by a governmental unit to the organization without charge..
4	Total. Add lines 1 through 3..
5	The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..
6	Public Support. Subtract line 5 from line 4.

Section B. Total Support

Calendar year(or fiscal year beginning in)		(a) 2006	(b) 2007	(c) 2008	(d) 2009	(e) 2010	(f) Total
7	Amounts from line 4..
8	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
9	Net income from unrelated business activities, whether or not the business is regularly carried on..
10	Other income. (Explain in Part IV.) Do not include gain or loss from the sale of capital assets..
11	Total support (Add lines 7 through 10).

Gross receipts from related activities, etc. (See instructions.) ..................

First Five Years If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization,
check this box and stop here.......................................... right arrow

Section C. Computation of Public Support Percentage

Public Support Percentage for 2010 (line 6 column (f) divided by line 11 column (f)) .........

Public Support Percentage for 2009 Schedule A, Part II, line 14 ...............

16a

33 1/3% support test—2010. If the organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box
and stop here. The organization qualifies as a publicly supported organization ...................... right arrow

33 1/3% support test—2009. If the organization did not check the box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow

17a

10%-facts-and-circumstances test—2010. If the organization did not check a box on line 13, 16a, or 16b and line 14
is 10% or more, and if the organization meets the "facts and circumstances" test, check this box and stop here. Explain
in Part IV how the organization meets the "facts and circumstances" test. The organization qualifies as a publicly supported
organization .................................................. right arrow

10%-facts-and-circumstances test—2009. If the organization did not check a box on line 13, 16a, 16b, or 17a and line
15 is 10% or more, and if the organization meets the "facts and circumstances" test, check this box and stop here.
Explain in Part IV how the organization meets the "facts and circumstances" test. The organization qualifies as a publicly
supported organization .............................................. right arrow

Private Foundation If the organization did not check a box on line 13, 16a, 16b, 17a or 17b, check this box and see
instructions ................................................... right arrow

Schedule A (Form 990 or 990-EZ) 2010

Page 3

Part III

Support Schedule for Organizations Described in IRC 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public Support

Calendar year(or fiscal year beginning in)		(a) 2006	(b) 2007	(c) 2008	(d) 2009	(e) 2010	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .
2	Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......
3	Gross receipts from activities that are not an unrelated trade or business under section 513..
4	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5	The value of services or facilities furnished by a governmental unit to the organization without charge..
6	Total. Add lines 1 through 5.
7a	Amounts included on lines 1, 2, and 3 received from disqualified persons...
b	Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.
c	Add lines 7a and 7b..
8	Public Support (Subtract line 7c from line 6.)

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2006	(b) 2007	(c) 2008	(d) 2009	(e) 2010	(f) Total
9	Amounts from line 6...
10a	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
b	Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.
c	Add lines 10a and 10b.
11	Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.
12	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)
13	Total support (Add lines 9, 10c, 11 and 12.).

Section C. Computation of Public Support Percentage

Public Support Percentage for 2010 (line 8 column (f) divided by line 13 column (f)) .........

Public support percentage from 2009 Schedule A, Part III, line 15 ...............

Section D. Computation of Investment Income Percentage

Investment income percentage for 2010 (line 10c column (f) divided by line 13 column (f)) ......

Investment income percentage from 2009 Schedule A, Part III, line 17 .............

19a

33 1/3% support tests—2010. If the organization did not check the box on line 14, and line 15 is more than 33 1/3% and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization .......... right arrow

33 1/3% support tests—2009. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization .... right arrow

Private Foundation If the organization did not check a box on line 14, 19a or 19b, check this box and see instructions ..... right arrow

Schedule A (Form 990 or 990-EZ) 2010

Page 4

Part IV

Supplemental Information. Supplemental Information. Complete this part to provide the explanation required by Part II, line 10; Part II, line 17a or 17b; or Part III, line 12. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Explanation
CHILDREN'S MERCY HOSPITAL IN KANSAS CITY, MISSOURI AND THE MASSACHUSETTS GENERAL HOSPITAL IN BOSTON, MASSACHUSETTS.

Schedule A (Form 990 or 990-EZ) 2010

Additional Data

Software ID:
Software Version:

- TIN:

Schedule B
(Form 990, 990-EZ,
or 990-PF)

Department of the Treasury
Internal Revenue Service

Schedule of Contributors

Attach to Form 990, 990-EZ, or 990-PF.

OMB No. 1545-0047

2010

Name of organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Organization type (check one):

Filers of:

Section:

Form 990 or 990-EZ

501(c)( ) (enter number) organization

4947(a)(1) nonexempt charitable trust not treated as a private foundation

527 political organization

Form 990-PF

501(c)(3) exempt private foundation

4947(a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule.
Note. Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.

General Rule

For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, $5,000 or more (in money or
property) from any one contributor. Complete Parts I and II.

Special Rules

For a section 501(c)(3) organization filing Form 990 or 990-EZ, that met the 33¹/3% support test of the regulations
under sections 509(a)(1) and 170(b)(1)(A)(vi), and received from any one contributor, during the year, a contribution of the
greater of (1) $5,000 or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h, or (ii) Form 990-EZ, line 1. Complete Parts I and II.

For a section 501(c)(7), (8), or (10) organization filing Form 990, or 990-EZ, that received from any one contributor,
during the year, aggregate contributions of more than $1,000 for use exclusively for religious, charitable,
scientific, literary, or educational purposes, or the prevention of cruelty to children or animals. Complete Parts I, II, and
III.

For a section 501(c)(7), (8), or (10) organization filing Form 990, or 990-EZ, that received from any one contributor,
during the year, contributions for use exclusively for religious, charitable, etc., purposes, but these contributions did
not aggregate to more than $1,000. If this box is checked, enter here the total contributions that were received during
the year for an exclusively religious, charitable, etc., purpose. Do not complete any of the parts unless the General Rule
applies to this organization because it received nonexclusively religious, charitable, etc., contributions of $5,000 or more
during the year. ......................... Arrow Bullet

Caution. An Organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2 of its Form 990, or check the box in the heading of its
Form 990-EZ, or on line 2 of its Form 990-PF, to certify that it does not meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).

For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.

Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2010)

Name of organization Stowers Institute for Medical Research
Schedule B (Form 990, 990-EZ, or 990-PF) (2010) Page 1 of 1 of Part I
Part I	Contributors (see Instructions)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
RESTRICTED	RESTRICTED RESTRICTED RESTRICTED RESTRICTED, RESTRICTED RESTRICTED	$RESTRICTED	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Aggregate contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II if there is a noncash contribution.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2010)

Name of organization Stowers Institute for Medical Research
Schedule B (Form 990, 990-EZ, or 990-PF) (2010) Page 1 of 1 of Part II
Part II	Noncash Property (see Instructions)
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (see instructions)	(d) Date received
		$
Schedule B (Form 990, 990-EZ, or 990-PF) (2010)

Schedule B (Form 990, 990-EZ, or 990-PF) (2010)

Page 1 of 1 of Part III

Name of organization
Stowers Institute for Medical Research

Employer identification number

20-2993509

Part III

Exclusively religious, charitable, etc., individual contributions to section 501(c)(7), (8), or (10) organizations
aggregating more than $1,000 for the year. (Complete columns (a) through (e) and the following line entry.)
For organizations completing Part III, enter the total of exclusively religious, charitable, etc.,
contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet

(a) No.
from
Part I

(b)
Purpose of gift

(d)
Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a) No.
from
Part I

(b)
Purpose of gift

(d)
Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a) No.
from
Part I

(b)
Purpose of gift

(d)
Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a) No.
from
Part I

(b)
Purpose of gift

(d)
Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

Schedule B (Form 990, 990-EZ, or 990-PF) (2010)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE D
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Financial Statements

Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11, or 12.
SchDMd Bullet

Attach to Form 990. SchDMd Bullet

See separate instructions.

OMB No. 1545-0047

2010

Open to Public Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.

		(a) Donor advised funds	(b) Funds and other accounts
1	Total number at end of year .......
2	Aggregate contributions to (during year) ...
3	Aggregate grants from (during year) ...
4	Aggregate value at end of year .......

Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............

Yes No

Did the organization inform all grantees, donors, and donor advisors in writing that grant funds may be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit. ...................................

Yes No

Part II

Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.

Purpose(s) of conservation easements held by the organization (check all that apply).

Preservation of land for public use (e.g., recreation or pleasure) Preservation of an historically importantly land area

Protection of natural habitat Preservation of a certified historic structure

Preservation of open space

Complete lines 2a–2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.


a	Total number of conservation easements .......................	2a
b	Total acreage restricted by conservation easements ..................	2b
c	Number of conservation easements on a certified historic structure included in (a) .....	2c
d	Number of conservation easements included in (c) acquired after 8/17/06 ........	2d

Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the taxable year SchDMd Bullet

Number of states where property subject to conservation easement is located SchDMd Bullet

Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................

Yes No

Staff and volunteer hours devoted to monitoring, inspecting and enforcing conservation easements during the year SchDMd Bullet

Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year SchDMd Bullet

Does each conservation easement reported on line 2(d) above satisfy the requirements of section
170(h)(4)(B)(i) and 170(h)(4)(B)(ii)? ....................................

Yes No

In Part XIV, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.

If the organization elected, as permitted under SFAS 116, not to report in its revenue statement and balance sheet works of
art, historical treasures, or other similar assets held for public exhibition, education or research in furtherance of public service,
provide, in Part XIV, the text of the footnote to its financial statements that describes these items.

If the organization elected, as permitted under SFAS 116, to report in its revenue statement and balance sheet works of art,
historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service,
provide the following amounts relating to these items:

(i)

Revenues included in Form 990, Part VIII, line 1 ........................ SchDMd Bullet

(ii)

Assets included in Form 990, Part X .............................. SchDMd Bullet

If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 relating to these items:

Revenues included in Form 990, Part VIII, line 1 .......................... SchDMd Bullet

Assets included in Form 990, Part X ............................... SchDMd Bullet

For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990

Cat. No. 52283D

Schedule D (Form 990) 2010

Page 2

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)

Using the organization’s accession and other records, check any of the following that are a significant use of its collection
items (check all that apply):

Public exhibition

Loan or exchange programs

Scholarly research

Other

Preservation for future generations

Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIV.

During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........

Yes No

Part IV

Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.

Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................

Yes No

If "Yes," explain the arrangement in Part XIV and complete the following table:


c	Beginning balance .................................	1c
d	Additions during the year ..............................	1d
e	Distributions during the year .............................	1e
f	Ending balance ...................................	1f

Did the organization include an amount on Form 990, Part X, line 21? .....................

Yes No

If “Yes,” explain the arrangement in Part XIV.

Part V

Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.

		(a)Current Year	(b)Prior Year	(c)Two Years Back	(d)Three Years Back	(e)Four Years Back
1a	Beginning of year balance ....
b	Contributions ........
c	Investment earnings or losses ...
d	Grants or scholarships .....
e	Other expenditures for facilities and programs ........
f	Administrative expenses ....
g	End of year balance ......

Provide the estimated percentage of the year end balance held as:

Board designated or quasi-endowment: SchDMd Bullet

Permanent endowment: SchDMd Bullet

Term endowment: SchDMd Bullet

Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes

(i) unrelated organizations ........................

3a(i)

(ii) related organizations ........................

3a(ii)

If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........

Describe in Part XIV the intended uses of the organization's endowment funds.

Part VI

InvestmentsLand, Buildings, and Equipment. See Form 990, Part X, line 10.

Description of investment		(b)Cost or other basis (other)	(c) Accumulated depreciation	(d) Book value
1a	Land .................	3,400,000		3,400,000
b	Buildings ................	223,610,985	58,984,180	164,626,805
c	Leasehold improvements ............
d	Equipment ................	82,167,263	60,928,345	21,238,918
e	Other .................	2,647		2,647
Total. Add lines 1a-1e. (Column (d) should equal Form 990, Part X, column (B), line 10(c).)........				189,268,370

Schedule D (Form 990) 2010

Page 3

Part VII

InvestmentsOther Securities. See Form 990, Part X, line 12.

(a) Description of security or category (including name of security)		(b)Book value	(c) Method of valuation: Cost or end-of-year market value
(1)Financial derivatives
(2)Closely-held equity interests
Other








Total. (Column (b) should equal Form 990, Part X, col.(B) line 12.)

Part VIII

InvestmentsProgram Related. See Form 990, Part X, line 13.

(a) Description of investment type		(b) Book value	(c) Method of valuation: Cost or end-of-year market value









Total. (Column (b) should equal Form 990, Part X, col.(B) line 13.)

Part IX

Other Assets. See Form 990, Part X, line 15.

(a) Description				(b) Book value
(1) ANNUITY RECEIVABLE				212,147,967
(2) OTHER RECEIVABLES				88,545







Total. (Column (b) should equal Form 990, Part X, col.(B) line 15.)...........				212,236,512

Part X

Other Liabilities. See Form 990, Part X, line 25.

1.(a) Description of Liability		(b) Amount
Federal Income Taxes		0
ADVANCES FROM AFFILIATES		4,803,017
ANNUITY PAYABLE		206,345,128







Total. (Column (b) should equal Form 990, Part X, col.(B) line 25.)		211,148,145
2. Fin 48 (ASC 740) Footnote. In Part XIV, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC740).

Schedule D (Form 990) 2010

Page 4

Part XI Reconciliation of Change in Net Assets from Form 990 to Financial Statements
1	Total revenue (Form 990, Part VIII, column (A), line 12) ....................	1
2	Total expenses (Form 990, Part IX, column (A), line 25) .....................	2
3	Excess or (deficit) for the year. Subtract line 2 from line 1 .............	3
4	Net unrealized gains (losses) on investments ..........................	4
5	Donated services and use of facilities .............................	5
6	Investment expenses ...................................	6
7	Prior period adjustments ..................................	7
8	Other (Describe in Part XIV) .................................	8
9	Total adjustments (net). Add lines 4 - 8 .............................	9
10	Excess or (deficit) for the year per financial statements. Combine lines 3 and 9 .........	10

Part XII Reconciliation of Revenue per Audited Financial Statements With Revenue per Return
1	Total revenue, gains, and other support per audited financial statements .......		1
2	Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a	Net unrealized gains on investments ..........	2a
b	Donated services and use of facilities .........	2b
c	Recoveries of prior year grants ...........	2c
d	Other (Describe in Part XIV): ............	2d
e	Add lines 2a through 2d .....................		2e
3	Subtract line 2e from line 1.....................		3
4	Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b .	4a
b	Other (Describe in Part XIV): ...........	4b
c	Add lines 4a and 4b.......................		4c
5	Total Revenue. Add lines 3 and 4c. (This should equal Form 990, Part I, line 12.) ......		5

Part XIII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return
1	Total expenses and losses per audited financial statements .............		1
2	Amounts included on line 1 but not on Form 990, Part IX, line 25:
a	Donated services and use of facilities ..........	2a
b	Prior year adjustments ..............	2b
c	Other losses ................	2c
d	Other (Describe in Part XIV): ............	2d
e	Add lines 2a through 2d......................		2e
3	Subtract line 2e from line 1.....................		3
4	Amounts included on Form 990, Part IX, line 25, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b ..	4a
b	Other (Describe in Part XIV): ............	4b
c	Add lines 4a and 4b.......................		4c
5	Total expenses. Add lines 3 and 4c. (This should equal Form 990, Part I, line 18.) ......		5

Part XIV

Supplemental Information

Complete this part to provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X; Part XI, line 8; Part XII, lines 2d and 4b; and Part XIII, lines 2d and 4b. Also complete this part to provide any additional information.

Identifier	Return Reference	Explanation
SCHEDULE D		PART X, LINE 2 - SUMMARY OF FIN 48 CONSOLIDATED FOOTNOTE AS IT APPLIES TO STOWERS INSTITUTE FOR MEDICAL RESEARCH - AN INTERPRETATION OF FASB STATEMENT NO. 109. THIS INTERPRETATION CLARIFIES THE ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES RECOGNIZED IN AN ENTERPRISE'S FINANCIAL STATEMENTS IN ACCORDANCE WITH FASB STATEMENT NO. 109, ACCOUNTING FOR INCOME TAXES. THIS INTERPRETATION ALSO PRESCRIBES A RECOGNITION THRESHOLD AND MEASUREMENT ATTRIBUTE FOR THE FINANCIAL STATEMENT RECOGNITION AND MEASUREMENT OF A TAX POSITION TAKEN OR EXPECTED TO BE TAKEN IN A TAX RETURN. STOWERS INSTITUTE FOR MEDICAL RESEARCH IS A TAX-EXEMPT ENTITY AS DESCRIBED IN SECTION 501 (c)(3) OF THE CODE. THEREFORE, IT IS STOWERS INSTITUTE FOR MEDICAL RESEARCH'S TAX POSITION THAT THEY ARE EXEMPT FROM FEDERAL INCOME TAXES. STOWERS INSTITUTE FOR MEDICAL RESEARCH ADOPTED FIN 48 EFFECTIVE JANUARY 1, 2007 WITH NO IMPACT TO ITS FINANCIAL STATEMENTS.

Schedule D (Form 990) 2010

Additional Data

Software ID:
Software Version:

- TIN:

Schedule I
(Form 990)

Department of the Treasury
Internal Revenue Service

Grants and Other Assistance to Organizations,
Governments and Individuals in the United States

Complete if the organization answered "Yes," to Form 990, Part IV, line 21 or 22.
lBullet

Attach to Form 990

OMB No. 1545-0047

2010

Open to Public
Inspection

Name of the organization
Stowers Institute for Medical Research

Employer identification number
20-2993509

Part I

General Information on Grants and Assistance

Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ....................................

Yes No

Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.

Part II

Grants and Other Assistance to Governments and Organizations in the United States. Complete if the organization answered "Yes" to
Form 990, Part IV, line 21 for any recipient that received more than $5,000. Check this box if no one recipient received more than $5,000. Use
Part IV and Schedule I-1 (Form 990) if additional space is needed ......................... lBullet

(a) Name and address of organization or government	(b) EIN	(c) IRC Code section if applicable	(d) Amount of cash grant	(e) Amount of non-cash assistance	(f) Method of valuation (book, FMV, appraisal, other)	(g) Description of non-cash assistance	(h) Purpose of grant or assistance

Enter total number of section 501(c)(3) and government organizations ......................... Bullet Image

Enter total number of other organizations ................................ . Bullet Image

For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50055P

Schedule I (Form 990) 2010

Page 2

Part III

Grants and Other Assistance to Individuals in the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 22.
Use Schedule I-1 (Form 990) if additional space is needed.

(a)Type of grant or assistance	(b)Number of recipients	(c)Amount of cash grant	(e)Method of valuation (book, FMV, appraisal, other)	(f)Description of non-cash assistance
(1) STIPENDS/FELLOWSHIPS	72	1,372,750	N/A	N/A

Part IV

Supplemental Information. Complete this part to provide the information required in Part I, line 2, and any other additional information.

Identifier	Return Reference	Explanation
SCHEDULE I	PART I, LINE 2	SIMR PROVIDES TRAINING STIPEND/FELLOWSHIPS TO UNDERGRADUATES, GRADUATES, AND POST-DOCTORAL CANDIDATES. THESE STIPENDS/FELLOWSHIPS ARE PROVIDED FOR THE INDIVIDUAL'S TRAINING AND NOT AS COMPENSATION FOR ANY SERVICES PROVIDED BY THEM TO SIMR. STIPENDS/FELLOWSHIPS ARE OFFERED ON A NON-DISCRIMINATORY BASIS TO INDIVIDUALS STUDYING A BASIC BIOMEDICAL FIELD WITH THE OBJECTIVE OF CONTINUING IN THIS FIELD UPON THE COMPLETION OF THEIR EDUCATION AND TRAINING.

Schedule I (Form 990) 2010

Additional Data

Software ID:
Software Version:

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Schedule J
(Form 990)

Department of the Treasury
Internal Revenue Service

Compensation Information

For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet

Complete if the organization answered "Yes" to Form 990,
Part IV, question 23.
SchJMediumBullet

Attach to Form 990. SchJMediumBullet

See separate instructions.

OMB No. 1545-0047

2010

Open to Public Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Questions Regarding Compensation

Yes

Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.

First-class or charter travel Housing allowance or residence for personal use

Travel for companions Payments for business use of personal residence

Tax idemnification and gross-up payments Health or social club dues or initiation fees

Discretionary spending account Personal services (e.g., maid, chauffeur, chef)

If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement orprovision of all the expenses described above? If "No," complete Part III to explain....

Yes

Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
officers, directors, trustees, and the CEO/Executive Director, regarding the items checked in line 1a? ....

Yes

Indicate which, if any, of the following the organization uses to establish the compensation of the
organization's CEO/Executive Director. Check all that apply.

Compensation committee Written employment contract

Independent compensation consultant Compensation survey or study

Form 990 of other organizations Approval by the board or compensation committee

During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:

Receive a severance payment or change-of-control payment? ...............

Participate in, or receive payment from, a supplemental nonqualified retirement plan? ........

Participate in, or receive payment from, an equity-based compensation arrangement? ........

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.

Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.

For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:

The organization? ...........................

Any related organization? .........................

If "Yes," to line 5a or 5b, describe in Part III.

For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:

The organization? ...........................

Any related organization? .........................

If "Yes," to line 6a or 6b, describe in Part III.

For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............

Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regs. section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................

If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................

For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990

Cat. No. 50053T

Schedule J (Form 990) 2010

Page 2

Part II

Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use Schedule J-1 if additional space needed.

For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.

Note. The sum of columns (B)(i)-(iii) must equal the applicable column (D) or column (E) amounts on Form 990, Part VII, line 1a.

(A) Name		(B) Breakdown of W-2 and/or 1099-MISC compensation			(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation reported in prior Form 990 or Form 990-EZ
(A) Name		(i) Base compensation	(ii) Bonus & incentive compensation	(iii) Other reportable compensation	(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)
(1) DAVID AWELTE	(i) (ii)	0 896,605	0 0	0 19,431	0 36,750	0 13,677	0 966,463	0 0
(2) RODERICK L STURGEON	(i) (ii)	0 1,059,859	0 0	0 41,885	0 36,750	0 10,660	0 1,149,154	0 0
(3) WILLIAM B NEAVES - SEE SCH O	(i) (ii)	676,394 0	0 0	25,527 0	36,750 0	10,408 0	749,079 0	0 0
(4) DAVID M CHAO	(i) (ii)	965,898 0	0 0	2,340 0	36,750 0	1,420 0	1,006,408 0	0 0
(5) ROBERT E KRUMLAUF - SEE SCH O	(i) (ii)	435,008 0	0 0	3,564 0	36,750 0	13,929 0	489,251 0	0 0
(6) RONALD C CONAWAY	(i) (ii)	239,625 0	0 0	1,186 0	35,944 0	4,882 0	281,637 0	0 0
(7) JOAN W CONAWAY	(i) (ii)	237,775 0	0 0	1,186 0	35,944 0	10,630 0	285,535 0	0 0
(8) JERRY L WORKMAN	(i) (ii)	234,653 0	0 0	1,161 0	35,273 0	6,623 0	277,710 0	0 0
(9) R SCOTT HAWLEY	(i) (ii)	239,694 0	0 0	2,160 0	35,129 0	13,883 0	290,866 0	0 0
(10) RONG LI	(i) (ii)	225,573 0	0 0	462 0	34,859 0	13,836 0	274,730 0	0 0
(11) RICHARD W BROWN	(i) (ii)	0 1,621,863	0 0	0 24,024	0 36,750	0 10,660	0 1,693,297	0 0

Schedule J (Form 990) 2010

Page 3

Part III

Supplemental Information

Complete this part to provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 4c, 5a, 5b, 6a, 6b, 7, and 8. Also complete this part for any additional information.

Identifier	Return Reference	Explanation
Schedule J		PART I, LINE 1A SIMR HAS WRITTEN EMPLOYMENT CONTRACTS WITH WILLIAM B. NEAVES, President Emeritus, AND DAVID M. CHAO, PRESIDENT, WHICH PROVIDES FOR TAXABLE TERM LIFE BENEFITS AND FOR THE EXECUTIVES TO RECEIVE TAX GROSS-UP PAYMENTS SUFFICIENT TO COVER THE TAXES ON THE BENEFITS. PART I, LINE 1B SIMR PROVIDED THE BENEFITS DESCRIBED IN RESPONSE TO LINE 1A PURSUANT TO WRITTEN EMPLOYMENT CONTRACTS THAT WERE APPROVED BY SIMR'S GOVERNING BOARD, SEE RESPONSE TO FORM 990, PART VI, SECTION B,LINE 15, FOR ADDITIONAL PROCESSES RELATED TO DETERMINING EXECUTIVE COMPENSATION.

Schedule J (Form 990) 2010

Additional Data

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Schedule L
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service

Transactions with Interested Persons

Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V lines 38a or 40b.
MediumBullet

Attach to Form 990 or Form 990-EZ. MediumBullet

See separate instructions.

OMB No. 1545-0047

2010

Open to Public Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Excess Benefit Transactions (section 501(c)(3) and section 501 (c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.

1(a) Name of disqualified person	(b) Description of transaction	(c) Corrected?
1(a) Name of disqualified person	(b) Description of transaction	Yes	No

Enter the amount of tax imposed on the organization managers or disqualified persons during the year under section 4958. ......................... Bullet Image

Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image

Part II

Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 26, or Form 990-EZ, Part V, line 38a.

(a) Name of interested person and purpose	(b) Loan to or from the organization?		(c)Original principal amount	(d)Balance due	(e) In default?		(f) Approved by board or committee?		(g)Written agreement?
(a) Name of interested person and purpose	To	From	(c)Original principal amount	(d)Balance due	Yes	No	Yes	No	Yes	No






Total ............... $

Part III

Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.

(a) Name of interested person	(b)Relationship between interested person and the organization	(c)Amount of grant or type of assistance

For Privacy Act and Paperwork Reduction Act Notice, see the
Instructions for Form 990 or 990-EZ.

Cat. No. 50056A

Schedule L (Form 990 or 990-EZ) 2010

Page 2

Part IV

Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of transaction	(d) Description of transaction	(e) Sharing of organization's revenues?
(a) Name of interested person		(c) Amount of transaction	(d) Description of transaction	Yes	No
(1) AMERICAN CENTURY COMPANIES INC	SEE PART V		SEE PART V		No
(2) JULIA ZEITLINGER PhD	SEE PART V	104,768	EMPLOYEE OF SIMR		No
(3) LEANNE WIEDEMANN PhD	SEE PART V	177,720	EMPLOYEE OF SIMR		No

Part V

Supplemental Information

Complete this part to provide additional information for responses to questions on Schedule L (see instructions).

Identifier	Return Reference	Explanation
SCHEDULE L, PART IV	Line 1, 2 & 3	PART IV, LINE (1): CURRENT DIRECTORS AND OFFICERS OF SIMR, RICHARD W. BROWN AND DAVID A. WELTE AND ALSO CURRENT DIRECTORS RODERICK L. STURGEON AND JAMES E. STOWERS JR. ARE DIRECTORS OF AMERICAN CENTURY COMPANIES, INC.("ACCI"). JAMES E. STOWERS JR. IS THE FOUNDER OF ACCI AND ALONG WITH OTHER FAMILY MEMBERS RETAINS A CONTROLLING VOTING INTEREST IN ACCI. SIMR RECEIVES INVESTMENT MANAGEMENT SERVICES FROM AMERICAN CENTURY INVESTMENTS ("ACI"). SIMR PAYS THE SAME ADMINISTRATIVE FEES FOR THESE SERVICES AS ANY ARMS-LENGTH MUTUAL FUND INVESTOR. THE VALUE OF THESE SERVICES, ESTIMATED BY MULTIPLYING SIMR'S AVERAGE AMOUNT OF MUTAL FUND HOLDINGS THROUGHOUT THE YEAR BY THE PUBLISHED ADMINISTRATIVE FEE PERCENTAGE FOR THE APPLICABLE FUNDS, WAS APPROXIMATELY $650,000. IN SELECTING ACI TO MANAGE ITS LIQUID INVESTMENTS, SIMR SELECTED A HIGH QUALITY MUTUAL FUND COMPANY WITH AN OUTSTANDING TRACK RECORD. SCHEDULE L, PART IV, LINE (2): JULIA ZEITLINGER, Ph.D, IS THE SPOUSE OF DAVID M. CHAO, PRESIDENT OF SIMR. MS. ZEITLINGER IS AN ASSISTANT INVESTIGATOR AT SIMR. MS. ZEITLINGER'S PREVIOUS EMPLOYMENT BEFORE SIMR WAS WITH WHITEHEAD INSTITUTE FOR MEDICAL RESEARCH WHERE SHE WAS THE RECIPIENT OF A POSTDOCTORAL FELLOWSHIP FROM THE HUMAN FRONTIER SCIENCE PROGRAM. SCHEDULE L, PART IV, LINE (3): LEANNE WIEDEMANN, P.h.D, IS THE SPOUSE OF ROBERT KRUMLAUF, SCIENTIFIC DIRECTOR OF SIMR. MS. WIEDEMANN PERFORMS INDEPENDENT SCIENCE RESEARCH AT SIMR AND IS CONCURRENTLY A PROFESSOR AT THE UNIVERSITY OF KANSAS MEDICAL CENTER IN THE DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE.

Schedule L (Form 990 or 990-EZ) 2010

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE M
(Form 990)

Department of the Treasury

Internal Revenue Service

NonCash Contributions

Complete if the organization answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image

Attach to Form 990.

OMB No. 1545-0047

2010

Open to Public Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Types of Property

	(a) Check if applicable	(b) Number of Contributions or items contributed	(c) Contribution amounts reported on Form 990, Part VIII, line 1g	(d) Method of determining contribution amounts
1 Art—Works of art ....
2 Art—Historical treasures .
3 Art—Fractional interests ..
4 Books and publications ..
5 Clothing and household goods .......
6 Cars and other vehicles ..
7 Boats and planes ....
8 Intellectual property ...
9 Securities—Publicly traded .	X	2	62,027	FAIR MARKET VALUE
10 Securities—Closely held stock .
11 Securities—Partnership, LLC, or trust interests ....
12 Securities—Miscellaneous ..
13 Qualified conservation contribution—Historic structures .....
14 Qualified conservation contribution—Other ...
15 Real estate—Residential .
16 Real estate—Commercial ..
17 Real estate—Other ...
18 Collectibles .....
19 Food inventory ...
20 Drugs and medical supplies .
21 Taxidermy ......
22 Historical artifacts ....
23 Scientific specimens ..
24 Archeological artifacts ...
25 Other ( )
26 Other ( )
27 Other ( )
28 Other ( )

Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement ...

Yes

30a

During the year, did the organization receive by contribution any property reported in Part I, lines 1-28 that it

must hold for at least three years from the date of the initial contribution, and which is not required to be used

for exempt purposes for the entire holding period? ..................

30a

If "Yes," describe the arrangement in Part II.

Does the organization have a gift acceptance policy that requires the review of any non-standard contributions?

Yes

32a

Does the organization hire or use third parties or related organizations to solicit, process, or sell non-cash

contributions? ............................

32a

If "Yes," describe in Part II.

If the organization did not report revenues in column (c) for a type of property for which column (a) is checked,

describe in Part II.

For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 51227J

Schedule M (Form 990) 2010

Page 2

Part II

Supplemental Information. Complete this part to provide the information required by Part I, lines 30b,
32b, and 33. Also complete this part for any additional information.

Identifier	Return Reference	Explanation

Schedule M (Form 990) 2010

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service

Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet

Attach to Form 990 or 990-EZ.

OMB No. 1545-0047

2010

Open to Public
Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Identifier	Return Reference	Explanation
SUPPLEMENTAL INFORMATION		FORM 990, PART III, LINE 1 THE STOWERS INSTITUTE FOR MEDICAL RESEARCH PERFORMS MEDICAL RESEARCH IN THE PUBLIC INTEREST IN CONJUNCTION WITH CHILDREN'S MERCY HOSPITAL IN KANSAS CITY, MISSOURI AND MASSACHUSETTS GENERAL HOSPITAL IN BOSTON, MASSACHUSETTS - BOTH SECTION 501(C)(3) AND 170(B)(1)(A)(III) HOSPITALS, WITH THE GOAL OF EXPANDING OUR UNDERSTANDING OF FUNDAMENTAL PROCESSES IN LIVING CELLS AND IMPROVING LIFE'S QUALITY THROUGH INNOVATIVE APPROACHES TO THE CAUSES, TREATMENT, AND PREVENTION OF DISEASE. FORM 990, PART III, LINE 4 SIMR'S ACCOMPLISHMENTS ARE DESCRIBED AT THE END OF SCHEDULE O. FORM 990, PART VI, LINE 2 JAMES E. STOWERS JR., RICHARD W. BROWN, RODERICK L. STURGEON AND DAVID A. WELTE, ALL DIRECTORS OF SIMR, HAVE A BUSINESS RELATIONSHIP; THEY ALL SERVE ON THE BOARD OF AMERICAN CENTURY COMPANIES, INC. AS DESCRIBED IN RESPONSE TO SCHEDULE L, PART IV. JAMES E. STOWERS JR., RICHARD W. BROWN, WILLIAM B. NEAVES, DAVID M. CHAO, AND RODERICK L. STURGEON, DIRECTORS OF SIMR, HAVE A BUSINESS RELATIONSHIP; THEY ALL SERVE ON THE BOARD OF BIOMED VALLEY DISCOVERIES, INC., A RELATED PARTY AS DISCUSSED ON SCHEDULE R. FORM 990, PART VI, LINE 11B THE DATA AND INFORMATION NECESSARY TO PREPARE SIMR'S FORM 990 WAS COMPILED BY SIMR'S ACCOUNTING DEPARTMENT AND THEN REVIEWED BY OUR TAX ATTORNEY AT BRYAN CAVE, LLC. KPMG, OUR EXTERNAL TAX PREPARERS, USE THIS INFORMATION TO PREPARE THE FORM 990. THE COMPLETED FORM 990, INCLUDING REQUIRED SCHEDULES, IS DISTRIBUTED IN ADVANCE TO ALL SEVEN OFFICERS OF SIMR FOR THEIR REVIEW AND COMMENTS BEFORE THE FORM 990 IS FILED WITH THE IRS. AFTER THE PREPARATION AND REVIEW PROCESS DESCRIBED ABOVE, THE FORM 990, INCLUDING REQUIRED SCHEDULES, IS PROVIDED TO EACH VOTING MEMBER OF THE ORGANIZATION'S BOARD BEFORE IT IS FILED WITH THE IRS. FORM 990, PART VI, LINE 12C SIMR HAS ADOPTED A "CONFLICTS OF INTEREST AND DIRECTOR INDEPENDENCE POLICY". EACH DIRECTOR, OFFICER, AND OTHER PERSON WHO IS IN A POSITION TO EXERCISE SUBSTANTIAL INFLUENCE OVER DECISIONS OF SIMR ARE REQUIRED TO ANNUALLY COMPLETE AND SIGN A DISCLOSURE STATEMENT THAT IS PART OF THE POLICY. A COVERED PERSON MUST ALSO DISCLOSE THE EXISTENCE OF A POTENTIAL CONFLICT AND ALL MATERIAL FACTS TO THE GOVERNING BOARD AS SOON AS THE PERSON HAS KNOWLEDGE THAT A POTENTIAL CONFLICT MIGHT EXIST. SIMR CONDUCTS PERIODIC AND ADHOC REVIEWS OF TRANSACTIONS AND AGREEMENTS TO INSURE THAT IT ENGAGES ONLY IN ACTIVITIES THAT ARE CONSISTENT WITH ITS TAX-EXEMPT PURPOSE. FORM 990, PART VI, LINES 15A & 15B THE PROCESS FOR DETERMINING COMPENSATION OF SIMR'S PRESIDENT AND CEO INCLUDED RETAINING THE SERVICES OF A NATIONALLY KNOWN COMPENSATION CONSULTANT TO PROVIDE DATA AND ANALYSIS TO DETERMINE COMPARABLE SALARY AND BENEFITS FOR SIMILARLY QUALIFIED PERSONS IN COMPARABLE POSTIONS AT SIMILARLY SITUATED ORGANIZATIONS. COMPENSATION WAS DOCUMENTED IN EMPLOYMENT CONTRACTS WHICH WERE APPROVED BY THE GOVERNING BODY AS DOCUMENTED IN THE OFFICIAL MINUTES. THE PROCESS WAS LAST UNDERTAKEN FOR THE PRESIDENT AND CEO POSITIONS IN 2009 AT THE TIME THE CURRENT CONTRACTS IN EFFECT WERE EXECUTED. FORM 990, PART VI, LINE 19 SIMR'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE ON REQUEST. FORM 990, PART VII - HOURS WORKED FOR RELATED ORGANIZATIONS AS DESCRIBED IN SCHEDULE R: RICHARD W. BROWN IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SRM. MR. BROWN ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SIMR, SSEI, BVC, AND BVD. DAVID A. WELTE IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SRM. MR. WELTE ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SRM, SREHC, AND SSEI. RODERICK L. STURGEON IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SRM. MR. STURGEON ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SRM, SIMR, SREHC, SSEI, AND BVD. WILLAM B. NEAVES IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SIMR. MR. NEAVES ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SRM, BVC, AND BVD. DAVID M. CHAO IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SIMR. MR. CHAO ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SRM AND BVD. ROBERT E. KRUMLAUF IS A FULL TIME EMPLOYEE, 40 HOURS PER WEEK, OF SIMR. MR. KRUMLAUF ALSO SPENDS AN AVERAGE OF 2.0 HOURS EACH PER WEEK SERVING AS A DIRECTOR OF SRM.
Other changes in net assets or fund balances	Form 990, Part XI, Line 5	Actuarial Loss on Annuity $(634,439) Unrealized Loss on Investments (172,617) Rounding (1) --------- Other changes in net assets or fund balances (807,057) =========
FORM 990, PART III, LINE 4		2010 Program Service Accomplishments The Stowers Institute for Medical Research ("SIMR") is a private, nonprofit medical research organization. SIMR was founded in 1994 by Jim and Virginia Stowers, two cancer survivors who have dedicated their fortune to supporting basic research in cell and molecular biology that will provide long-term solutions to gene-based diseases. SIMR conducts basic biomedical research in the public interest that will ultimately provide a greater understanding of the genes and proteins that control how cells in our bodies multiply, form tissues, and die. Like a growing number of scientists today, Institute scientists are convinced that by studying the basic biology of cells they will discover how genes cause many diseases, including cancer, diabetes, and dementia. Basic research conducted at SIMR should point the way to the development of new preventions, treatments, and cures for genetic diseases. 2010 Notable Research Results In 2010, SIMR research teams made discoveries meriting publication in leading peer reviewed scientific journals - 54 papers in all. SIMR research teams also published 44 reviews, commentaries, chapters, and two books. Highlights among 2010's published papers include: The Si Lab published results that suggest that ApCPEB acts as a self-sustaining prion-like protein in the nervous system, enabling it to play a role in memory formation. (February 5 issue of Cell). The Shilatifard Lab, in collaboration with the Conaway Lab and the Proteomics Center, identified a protein called AFF4 that associates with mutant proteins commonly found in mixed lineage leukemia and that may be a key regulator of leukemia development. (February 12 issue of Molecular Cell). The Mak Lab reported novel defects that result in expansion of lipid droplets in the roundworm Caenorhabditis elegans, contributing to the elucidation of cellular pathways that regulate fat storage. (March 9 issue of the Proceedings of the National Academy of Sciences and published online on February 22). The Kulesa Lab and the Microscopy Center showed that multicolor cell labeling and multispectral imaging enable more accurate cell tracking in the chick neural crest, an important developmental structure. (September 24 issue of BMC Developmental Biology). The Baumann Lab collaborated with Bill Neaves, Ph.D., President Emeritus, the Microscopy Center, and the Reptile and Aquatics Facility to reveal unique aspects of meiosis in parthenogenetic whiptail lizards that enable these female lizards to preserve existing genetic variation when reproducing asexually. (March 11 issue of Nature and published online on February 21). The Yu Lab showed that high and low concentrations of pheromones activate different subsets of neurons, helping to explain how mammalian species respond differently to different concentrations of pheromone cues. (June 2 issue of the Journal of Neuroscience). The Gibson Lab discovered and characterized a novel red fluorescent protein in the sea anemone Nematostella vectensis, defining Nematostella as a new model organism for studying the natural functions of fluorescent proteins. (Published online in PLoS ONE on July 27). The Hawley Lab provided the first direct evidence that the protein calcineurin is essential for the completion of meiosis in Drosophila oocytes. (August 15 issue of Developmental Biology and published online on June 16) The Workman Lab, in collaboration with the Abmayr Lab, Proteomics Center, and Bioinformatics Research, revealed that a protein complex called ATAC helps to modulate the cellular response to osmotic stress. (September 3 issue of Cell). The Krumlauf Lab demonstrated that the protein Wise regulates the well-studied Wnt protein signaling pathway to control tooth development, including tooth number and shape. (October issue of Development and published online on August 19). The Blanchette Lab, in collaboration with scientists outside the Institute, reported a novel aspect of the exon junction complex (EJC), a protein complex that assembles on messenger RNA as a consequence of splicing, or the removal of non-coding sequences called introns. (October issue of Nature Structural and Molecular Biology and published online on September 5).
FORM 990, PART III, LINE 4		The Jaspersen Lab, in collaboration with scientists outside the Institute, revealed an unexpected relationship between the yeast protein Mps3, components of the nuclear pore complex, and lipids of nuclear membrane. (November issue of Genetics and published online on August 16). The Rong Li Lab, in collaboration with the Proteomics Center, Molecular Biology, and Bioinformatics Research, demonstrated how aneuploidy in budding yeast can cause changes in gene expression and confer a growth advantage in certain environmental conditions. (November 11 issue of Nature and published online on October 20). The Xie Lab published work showing how the protein Lissencephaly-l may regulate the self-renewal state of adult stem cells. (November 16 issue of the Proceedings of the National Academy of Sciences and published online on November 1). The Gerton Lab, in collaboration with the Workman Lab and the Proteomics Center, uncovered the roles of two proteins, Psh1 and Scm3, in helping to ensure the presence of only one centromere per chromosome. (November 12 issue of Molecular Cell). Comprehensive List of 2010 Original Research Papers; Reviews, Commentaries or Chapters; and Books Original Research Papers Ahn Y, Sanderson BW, Klein OD, Krumlauf R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010;137:3221-3231. Blin G, Nury D, Stefanovic S, Neri T, Guillevic 0, Brinon B, Bellamy V, Rucker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagege A, Desnos M, Renaud JF, Menasche P, Puceat M. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest. 2010;120:1125-1139. Bosl WJ, Li R. The role of noise and positive feedback in the onset of autosomal dominant diseases. BMC Syst Biol. 2010;4:93. Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW, conaway RC. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J BioL Chem. 2010;285:4268-4272. Chen S, Kaneko S, Ma X, Chen X, Ip YT, Xu L, Xie T. Lissencephaly-l controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. Proc Natl Acad Sci USA. 2010;107:19939-19944. D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466:138-142. Egli D, Eggan K. Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development. 2010;137:1953-1963. Eldakak A, Rancati G, Rubinstein B, Paul P, Conaway V, Li R. Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing. Nat Cell Biol. 2010;12:799-805. Fournier ML, Paulson A, Pavelka N, Mosley AL, Gaudenz K, Bradford WD, Glynn E, Li H, Sardiu ME, Fleharty B, Seidel C, Florens L, Washburn MP. Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin. Mol Cell Proteomics. 2010;9:271-284. Govind CK, Qiu H, Ginsburg DS, Ruan C, Hofmeyer K, Hu C, Swaminathan V, Workman JL, Li B, Hinnebusch AG. Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Mol Cell. 2010;39:234-246. He J, Ma L, Kim S, Schwartz J, Santilli M, Wood C, Durnin MH, Yu CR. Distinct Signals Conveyed to Pheromone Concentrations to the Mouse Vomeronasal Organ. J Neurosci. 2010;30:7473-7483. Helston RM, Box JA, Tang W, Baumann P. Schizosaccharomyces cryophilus sp. nov., a new species of fission yeast. FEMS Yeast Res. 2010;10:779-786. Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A. The H3K27me3 demethylase dUTX is a suppressor of Notch and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010;30:2485-2497. Hewawasam G, Shivaraju M, Mattingly M, Venkatesh S, Martin-Brown S, Florens L, Workman JL, Gerton JL. Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell. 2010;40:444-454. Ikmi A, Gibson MC. Identification and in vivo characterization of NvFP-7R, a developmentally regulated red fluorescent protein of Nematostella vectensis. PLoS Biol. 2010;5:EI1807. Kasemeier-Kulesa JC, McLennan R, Romine MH, Kulesa PM, Lefcort F. CXCR4 controls ventral migration of sympathetic precursor cells. J Neurosci. 2010;30: 13078-13088. Kim JH, Saraf A, Florens L, Washburn M, Workman JL. Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2. Genes Dev. 2010;24:2766-2771. Korfali N, Wilkie GS, Swanson SK, Srsen V, Batrakou DG, Fairley EA, Malik P, Zuleger N, Goncharevich A, de Las Heras J, Kelly DA, Kerr AR, Florens L, Schirmer EC. The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture. Mol Cell Proteomics. 2010;9:2571-2585.
FORM 990, PART III, LINE 4		Kristensen dM, Kannan L, Coleman MK, Wolf YI, Sorokin A, Koonin EV, Mushegian A. A Low-Polynomial Algorithm For Assembling Clusters of Orthologous Groups From Intergenomic Symmetric Best Matches. Bioinformatics. 2010. Kristensen DM, Mushegian AR, Dolja VV, Koonin EV. New dimensions of the virus world discovered through metagenomics. Trends Microbiol. 2010;18:11-19. Kulesa PM, Gammill LS. Neural crest migration: Patterns, phases and signals. Dev BioL. 2010;344:566-568. Kulesa PM, Teddy JM, Smith M, Alexander R, Cooper CH, Lansford R, McLennan R. Multispectral fingerprinting for improved in vivo cell dynamics analysis. BMC Dev Biol. 2010;10:101. Kwon SH, Florens L, Swanson SK, Washburn MP, Abmayr SM, Workman JL. Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev. 2010;24:2133-2145. Lang C, Grava S, Finlayson M, Trimble R, Philippsen P, Jaspersen SL. Structural mutants of the spindle pole body cause distinct alteration of cytoplasmic microtubules and nuclear dynamics in multinucleated hyphae. Mol BioL Cell. 2010;21:753-766. Lang C, Grava S, van den Hoorn T, Trimble R, Philippsen P, Jaspersen SL. Mobility, microtubule nucleation and structure of microtubule-organizing centers in multinucleated hyphae of Ashbya gossypii. Mol BioL Cell. 2010;21:18-28. Lin C, Smith ER, Takahashi H, Lai KC, Martin-Brown S, Florens L, Washburn MP, Conaway JW, Conaway RC, Shilatifard A. AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell. 2010;37:429-437. Lu S, Goering M, Gard S, Xiong B, McNairn AJ, Jaspersen SL, Gerton JL. Eco1 is important for DNA damage repair in S. cerevisiae. Cell Cycle. 2010;9:1-13. Lutes AA, Neaves WB, Baumann DP, Wiegraebe W, Baumann P. Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards. Nature. 2010;464:283-286. Mastushita-Sakai T, White-Grindley E, Samuelson J, Seidel C, Si K. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Proc Natl Acad Sci USA. 2010;107:11987-11992. McLennan R, Kulesa PM. Neuropilin-1 interacts with the second branchial arch microenvironment to mediate chick neural crest cell dynamics. Dev Dyn. 2010;239:1664-1673. McLennan R, Teddy JM, Kasemeier-Kulesa JC, Romine MH, Kulesa PM. Vascular endothelial growth factor (VEGF) regulates cranial neural crest migration in vivo. Dev BioL. 2010;339:114-125. Mogilner A, Rubinstein B. Actin disassembly 'clock' and membrane tension determine cell shape and turning: a mathematical model. J Phys Condensed Matter. 2010;22:194118. Mohan M, Herz HM, Takahashi YH, Lin C, Lai KC, Zhang Y, Washburn MP, Florens L, Shilatifard A. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev. 2010;24:574-589. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010;24:312-326. Nugent RL, Johnsson A, Fleharty B, Gogol M, Xue-Franzen Y, Seidel C, Wright AP, Forsburg SL. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation. BMC Genomics. 2010;11:59. Ozbudak EM, Tassy O, Pourquie O. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Proc Natl Acad Sci USA. 2010;107:4224-4229. Pattenden SG, Gogol MM, Workman JL. Features of cryptic promoters and their varied reliance on bromodomain-containing factors. PLoS One. 2010;5:e12927. Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature. 2010;468:321-325. Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. Dynamic imaging of mammalian neural tube closure. Dev BioL. 2010;344:941-947. Sauliere J, Haque N, Harms S, Barbosa I, Blanchette M, Le Hir H. The exonjunction complex differentially marks spliced junctions. Nat Struct Mol BioL. 2010;17:1269-1271. Si K, Choi YB, White-Grindley E, Majumdar A, Kandel ER. Aplysia CPEB can form prionlike multimers in sensory neurons that contribute to long-term facilitation. Cell. 2010;140:421-435. Smith KT, Martin-Brown SA, Florens L, Washburn MP, Workman JL. Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. Chem BioL (Lond). 2010;17:65-73. Suganuma T, Mushegian A, Swanson SK, Abmayr SM, Florens L, Washburn MP, Workman JL. The ATAC Acetyltransferase Complex Coordinates MAP Kinases to Regulate JNK Target Genes. Cell. 2010;142:726-736.
FORM 990, PART III, LINE 4		Takeo S, Hawley RS, Aigaki T. Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Dev BioL. 2010;344:957-967. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010;7:618-630. Witkin KL, Friederichs JM, Cohen-Fix O, Jaspersen SL. Changes in the Nuclear Envelope Environment Affect Spindle Pole Body Duplication in Saccharomyces cerevisiae. Genetics. 2010;186:867-883. Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-1084. Xiong B, Lu S, Gerton JL. Hos1 is a lysine deacetylase for the smc3 subunit of cohesin. Curr Biol. 2010;20:1660-1665. Zeng Y, Li H, Schweppe NM, Hawley RS, Gilliland WD. Statistical analysis of nondisjunction assays in Drosophila. Genetics. 2010;186:505-513. Zhang D, O'Neil M F, Cunningham MT, Fan F, Olyaee M, Li L. Abnormal Wnt signaling and stem cell activation in reactive lymphoid tissue and low-grade marginal zone lymphoma. Leuk Lymphoma. 2010;51:906-910. Zhang SO, Mathur S, Hattem G, Tassy o, Pourquie o. Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos. BMC Genomics. 2010;11:13. Zhang SO, Trimble R, Guo F, Mak HY. Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol. 2010;11:96. Zhang Y, Wen Z, Washburn MP, Florens L. Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins. Anal Chem. 2010;82:2272-2281. Reviews, Commentaries or Chapters Aulehla A, Pourquie o. Signaling gradients during paraxial mesoderm development. Cold Spring Harb Perspect Biol. 2010;2:a000869 . Baumann P, Price C. Potl and telomere maintenance. FEBS Lett. 2010;584:3779-3784. Benazeraf B, Francois P, Baker RE, Denans N, Little CD, Pourquie O. A random cell motility gradient downstream of FGF controls elongation of an amniote embryo. Nature. 2010;466:248-252. Bose T, Gerton J. Cohesinopathies, gene expression, and chromatin organization. J Cell Biol. 2010;189:201-210. Bryan TM, Baumann P. G-quadruplexes: from guanine gels to chemotherapeutics. Methods Mol Biol. 2010;608:1-16. Eissenberg JC, Shilatifard A. Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol. 2010;339:240-249. Gilmore JM, Washburn MP. Advances in shotgun proteomics and the analysis of membrane proteomes. J Proteomics. 2010;73:2078-2091. Haralalka S, Abmayr SM. Myoblast fusion in Drosophila. Exp Cell Res. 2010;316:3007-3013. Herz HM, Shilatifard A. The JARID2-PRC2 duality. Genes Dev. 2010;24:857-861. Ichida JK, Kiskinis E, Eggan K. Shushing down the epigenetic landscape towards stem cell differentiation. Development. 2010;137:2455-2460. Inman K, Ezin M, Bronner-Fraser M, Trainor P. Role of Cardiac Neural Crest Cells in orphogenesis of the Heart and Great Vessels. Heart Development and Regeneration. 1st ed. Amsterdam: Elsevier/Academic Press; 2010;1:417-434.
FORM 990, PART III, LINE 4		Kim JH, Workman JL. Histone acetylation in heterochromatin assembly. Genes Dev. 2010;24:738-740. Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. 2010;120:51-59. Krumlauf R, Levine M. Gene expression and development. Special introduction. Dev Biol. 2010;339:224. Kulesa PM, Bailey CM, Cooper C, Fraser SE. In ovo live imaging of avian embryos. Cold Spring Harb Protoc. 2010;2010:pdb prot5446. Kulesa PM, Bailey CM, Kasemeier-Kulesa JC, McLennan R. Cranial neural crest migration: New rules for an old road. Dev Biol. 2010;344:543-554. Lee JS, Smith E, Shilatifard A. The language of histone crosstalk. Cell. 2010;142:682-685. Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science. 2010;327:542-545. Li R. Myosin-II Puts the Squeeze on Asymmetric Cell Division. Dev Cell. 2010;19:639-640. Li R, Bowerman B. Symmetry breaking in biology. Cold Spring Harb Perspect Biol. 2010;2:a003475. Mohan M, Lin C, Guest E, Shilatifard A. Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer. 2010;10:721-728. Pavelka N, Rancati G, Li R. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol. 2010;22:809-15. Perry JM, Li L. Functional assays for hematopoietic stem cell self-renewal. Methods Mol Biol. 2010;636:45-54. Sarthy JF, Baumann P. Apollo-Taking the Lead in Telomere Protection. Mol Cell. 2010;39:489-491. Shen R, Xie T. NANOS: a germline stem cell's Guardian Angel. J Mol Cell Biol. 2010;2:76-77. Slaughter BD, Li R. Toward Quantitative "in vivo biochemistry" with Fluorescence Fluctuation Spectroscopy. Mol Biol Cell. 2010;21:4306-4311. Slaughter BD, Smith SE, Li R. Symmetry breaking in the life cycle of the budding yeast. In: R Li, and B Bowerman, eds. Symmetry Breaking in Biology. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press; 2010:99-116. Smith E, Shilatifard A. The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes. Mol Cell. 2010;40:689-701. Steen J, Morrison JA, Kulesa PM. Multi-position photoactivation and multi-time acquisition for large-scale cell tracing in avian embryos. Cold Spring Harb Protoc. 2010;2010:pdb prot5447. Suganuma T, Workman JL. Features of the PHF8/KIAA1718 histone demethylase. Cell Res. 2010;20:861-862. Suganuma T, Workman JL. WD40 repeats arrange histone tails for spreading of silencing. J Mol Cell Biol. 2010;2:81-83. Sugimura R, Li L. Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases. Birth Defects Res C Embryo Today. 2010;90:243-256. Sugimura R, Li L. Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis. J Mol Cell Biol. 2010;2:61-62. Takahashi YH, Shilatifard A. Structural basis for H3K4 trimethylation by yeast Set1/COMPASS. Adv Enzyme Regul. 2010;50:104-110. Tenzen T, Zembowicz F, Cowan CA. Genome modification in human embryonic stem cells. J Cell Physiol. 2010;222:278-281. Trainor P A. Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention. Am J Med Genet A. 2010. Vilhais-Neto GC, Maruhashi M, Smith KT, Vasseur-Cognet M, Peterson AS, Workman JL, Pourquie O. Rere controls retinoic acid signalling and somite bilateral symmetry. Nature. 2010;463:953-957. Washburn MP. Driving biochemical discovery with quantitative proteomics [published ahead of print October 1 2010]. Trends Biochem Sci. 2010. Weake VM, Workman JL. Inducible gene expression: diverse regulatory mechanisms. Nat Rev Genet. 2010;11:426-437. Xiong B, Gerton JL. Regulators of the cohesin network. Annu Rev Biochem. 2010;79:131-153. Yin T, Li L. Fountain of Youth: aged blood-forming stem cells could be rejuvenated by young microenvironment. Cell Res. 2010;20:504-505. Zeitlinger J, Stark A. Developmental gene regulation in the era of genomics. Dev Biol. 2010;339:230-239.
FORM 990, PART III, LINE 4		Zhang SO, Box AC, Xu N, Le Men J, Yu J, Guo F, Trimble R, Mak HY. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Proc Natl Acad Sci USA. 2010;107:4640-4645. Books Baumann P. G-Quadruplex DNA. Vol 608: Springer Verlag, Humana Press; 2010. Li R, Bowerman B. Symmetry Breaking in Biology, 1st ed. Cold Spring Harbor, N.Y., Cold Spring Harbor Laboratory Press. 2010. Competitive Research Grant Funding & Research Awards & Distinctions The ability of Stowers Institute scientists to receive increasing numbers of competitively awarded research grants attests to the high level of research productivity present at the Institute. During 2010, Stowers scientists worked with the support of 21 grants and fellowships from the National Institutes of Health, two grants and one fellowship from the American Cancer Society, one award from Alex's Lemonade Stand Foundation, two fellowships from The Leukemia and Lymphoma Society, one award from the Klingenstein Fund, one award from the McKnight Foundation, one grant from the Greater Kansas City Community Foundation, one Hudson Prize from the M.R. and Evelyn Hudson Foundation, one award from the Kansas City Area Life Sciences Institute, one March of Dimes award, one award from the Midwest Cancer Alliance, one Pew Scholar Award, one award from the Burroughs Wellcome Fund, one investigator award from the Howard Hughes Medical Institute, and one fellowship from The Jane Coffin Childs Memorial Fund. With new and recurring grant support, the Institute is receiving more than $5 million a year in research funding to supplement the income from its endowments. Testifying to the high level of achievement taking place at the Institute are the awards and honors Institute scientists received in 2010: R. Scott Hawley, Ph.D., Investigator, received an American Cancer Society grant, effective in January. Ali Shilatifard, Ph.D., Investigator, received two National Institutes of Health grants, effective in March and December, and an Innovation Award from Alex's Lemonade Stand Foundation, effective in July. Paul Trainor, Ph.D., Associate Investigator, received a National Institutes of Health grant, effective in July, was a sub-recipient on another National Institutes of Health grant from the University of Kansas Medical Center, effective in July, and was a subrecipient on a Kansas City Area Life Sciences Institute grant from the University of Missouri-Kansas City, effective in August. Joan Conaway, Ph.D., Investigator, and Ronald Conaway, Ph.D., Investigator, received a National Institutes of Health grant, effective in July. Kausik Si, Ph.D., Assistant Investigator, received the 2010 Hudson Prize from the M.R. and Evelyn Hudson Foundation, effective in July. Erin Guest, Ph.D., Visiting Scientist in the Shilatifard Lab, received a Midwest Cancer Alliance grant, effective in July. Laurence Florens, Ph.D., Head of Proteomics, was a sub-recipient on a National Institutes of Health grant from the University of California, Riverside, effective in September. Caleb Bailey, Ph.D., Postdoctoral Research Associate in the Kulesa Lab, received a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health, effective in September. Linheng Li, Ph.D., Investigator, was elected as a Fellow of the American Association for the Advancement of Science in the Section on Medical Sciences in December. Cooperation Agreements and Collaborations
FORM 990, PART III, LINE 4		The Stowers Institute continued collaborations in 2010 with hospitals in Kansas City (Children'S Mercy and St. Luke's) and in Boston (Massachusetts General Hospital and Children's Hospital Boston). The Institute also collaborates with University of Missouri at Kansas City, University of Kansas, Howard Hughes Medical Institute, Harvard University, Harvard Stem Cell Institute, Harvard Medical School, Broad Institute, and Columbia University, most of which are associated with teaching and research hospitals. Additional collaborations occurred in 2010 with University of California at San Francisco; INSERM U633, Avenir Program, Embryonic Stem Cells and Cardiogenesis, Evry, France; University Montpellier II, France; University Paris Descartes, France; CNRS-UMR 8162, Universite Paris-Sud; Hopital Marie Lannelongue, Le Plessis Robinson, France; CNRS University of Nice Sophia Antipolis; Institut de Pharmacologie Moleculaire et Cellulaire, Nice, France; Assistance Publique-Hopitaux de Paris (AP-HP); Hopital Europeen Georges-Pompidou; Oregon National Primate Research Center; Institut de Medecine Aerospatiale du Service de Sante des Armees (IMASSA), Bretigny sur Orge, France; Dartmouth Medical School; University of Massachusetts Medical School; New York University School of Medicine; National Institute of Child Health and Human Development; Oakland University; University of Texas Southwestern Medical Center; M. D. Anderson Cancer Center; University of California at Berkeley; Wistar Institute; The Open University; Montana State University; Wellcome Trust; National Center for Biotechnology Information; Oregon State University; University of Minnesota; California Institute of Technology; Biozentrum University of Basel; University of California, Davis; Johns Hopkins Bloomberg School of Public Health; University of Southern California; Karolinska Institutet, Sodertorn University; Institut de Genetique et de Biologie Moleculaire et Cellulaire; Institut National de la Sante et de la Recherche Medicale; Centre National de la Recherche Scientifique, Universite de Strasbourg; University of Colorado; SloanKettering Institute; Centre National de la Recherche Scientifique UMR8197, Paris, France; Kavli Institute for Brain Science; Tokyo Metropolitan University; Immune Disease Institute; DanaFarber Cancer; Boston University; Brigham and Women's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Medical College of Wisconsin; Kansas City University of Medicine and Biosciences; DePaul University; University of Cincinnati; The Rockefeller University; University of Oxford; Saint Louis University School of Medicine; Hubrecht Institute; University of Oregon; Center for Regenerative Medicine; Cardiovascular Research Center; Universite' Paris Descartes; Genentech; and Research Institute of Molecular Pathology. Independent Research Program Leaders Laboratories Individual scientists at the Stowers Institute specialize in the study of one or more particular genes, each of which may cause or have influence in various kinds of disease. A comprehensive list of research leaders follows. Robert Krumlauf, Ph.D., Scientific Director and Investigator, joined the Stowers Institute in 2000 from England's National Institute for Medical Research, The Ridgeway, Mill Hill, London, where he was head of the Division of Developmental Neurobiology. Dr. Krumlauf received a Ph.D. in developmental biology from Ohio State University. Research Focus: AnalysiS of molecular pathways that regulate how the mammalian head, brain and nervous system are built, using a variety of vertebrate model systems. Susan Abmayr, Ph.D., Associate Investigator, joined the Stowers Institute in 2003 from the Pennsylvania State University where she served as Associate Professor of Molecular Genetics. She earned a Ph.D. in biochemistry and molecular biology from the Rockefeller University and completed postdoctoral training in the Department of Biochemistry and Molecular Biology at Harvard University under the direction of Professor Tom Maniatis. Research Focus: Molecular genetics of cell fate specification and differentiation in Drosophila, using the embryonic development of the musculature as a model system.
FORM 990, PART III, LINE 4		Peter Baumann, Ph.D., Associate Investigator and Howard Hughes Medical Institute Early Career Scientist, joined the Stowers Institute in 2002 after completing a Howard Hughes Medical Institute postdoctoral fellowship in the laboratory of Dr. Thomas R. Cech at the University of Colorado-Boulder. Dr. Baumann received a Ph.D. in biochemistry from the Imperial Cancer Research Fund and University College, London. Research Focus: Functional analysis of telomeres and their roles in cellular immortality and cancer. Marco Blanchette, Ph.D., Assistant Investigator, joined the Stowers Institute in 2006 from a postdoctoral position with Dr. Donald C. Rio at the University of California-Berkeley where he was recipient of a Human Frontier Long-Term Fellowship. Dr. Blanchette received a Ph.D. degree in microbiology from the Universite de Sherbrooke, Canada. Research Focus: Functional genomic analysis of the mechanisms controlling alternative pre-mRNA splicing. Joan Conaway, Ph.D., Investigator,joined the Stowers Institute in 2001 from the Oklahoma Medical Research Foundation where she was an Associate Investigator of the Howard Hughes Medical Institute and interim head of the program in Molecular and Cell Biology. Dr. Conaway received her doctorate in cell biology from Stanford University School of Medicine. Research Focus: Analysis of the molecular mechanism and regulation of gene transcription. Ronald Conaway, Ph.D., Investigator, joined the Stowers Institute in 2001 from the Oklahoma Medical Research Foundation where he was holder of the Chapman Chair in Medical Research. Dr. Conaway received his Ph.D. in biochemistry from Stanford University School of Medicine. Research Focus: Analysis of the molecular mechanism and regulation of gene transcription. Jennifer Gerton, Ph.D., Associate Investigator, joined the Stowers Institute in 2002 from a postdoctoral fellowship in the laboratory of Dr. Joseph DeRisi in the Department of Biochemistry and Biophysics at the University of California-San Francisco. Dr. Gerton received a Ph.D. in microbiology and immunology from Stanford University. Research Focus: Genomic and genetic analysis of chromosome segregation and chromosome dynamics. Matthew Gibson, Ph.D., Assistant Investigator, joined the Stowers Institute in 2006 from a Jane Coffin Childs Memorial Fund postdoctoral fellowship with Dr. Norbert Perrimon at Harvard Medical School. Dr. Gibson received a Ph.D. in zoology from the University of Washington. Research Focus: Genetic analysis of mechanisms controlling signal transduction, cell proliferation, and epithelial morphogenesis during Drosophila development. R. Scott Hawley, Ph.D., Investigator, joined the Stowers Institute in 2001 from the University of California-Davis where he was a professor of genetics in the Molecular and Cellular Biology section. Dr. Hawley earned a Ph.D. in genetics from the University of Washington and completed postdoctoral training as a Helen Hay Whitney Fellow at the Institute for Cancer Research in Philadelphia. Research Focus: Investigation of mechanisms that influence how chromosomes pair and segregate during meiosis using Drosophila as an experimental system. Sue Jaspersen, Ph.D., Assistant Investigator, joined the Stowers Institute in 2005 from the laboratory of Dr. Mark Winey at the University of Colorado-Boulder where she was a Keck Foundation Fellow, a Helen Hay Whitney Fellow, and the recipient of a Leukemia & Lymphoma Society Career Development Award. Dr. Jaspersen holds a Ph.D. in biochemistry from the University of California-San Francisco. Research Focus: Inner nuclear membrane protein localization and role in chromosome positioning and segregation.
FORM 990, PART III, LINE 4		Linheng Li, Ph.D., Investigator, joined the Stowers Institute in 2000 from the University of Washington Medical Center where he held a faculty appointment after completing postdoctoral training in the laboratory directed by Dr. Leroy Hood. Dr. Li earned his Ph.D. in molecular and cellular biology from New York University Medical School under the mentoring of Dr. Edward Ziff. Research Focus: Investigation of molecular and genetic pathways controlling adult stem cell development in the hematopoietic and intestinal systems using transgenic and gene targeting animal model approaches. Rong Li, Ph.D., Investigator, joined the Stowers Institute in 2005 from the Department of Cell Biology at Harvard Medical School where she served as an Associate Professor. She earned a Ph.D. in cell biology at the University of California-San Francisco with Dr. Andrew Murray and held a Damon Runyon-Walter Winchell Cancer Research Fellowship as a postdoctoral associate with Dr. David Drubin at the University of California-Berkeley. Research Focus: Mechanism of cell polarization and cell motility, genome dynamics and cellular evolvability, and epithelial tissue morphogenesis. Ho Yi Mak, Ph.D., Assistant Investigator, joined the Stowers Institute in 2006 from a Human Frontier Science Program postdoctoral fellowship in the laboratory of Dr. Gary Ruvkun at Harvard Medical School. Dr. Mak received a Ph.D. in molecular pathology from the Imperial Cancer Research Fund and University College, London. Research Focus: Analysis of molecular pathways that regulate cellular fat storage in response to nutrient availability and lipid metabolism. Ali Shilatifard, Ph.D., Investigator, joined the Stowers Institute in 2007 from the Saint Louis University School of Medicine where he was a Professor of Biochemistry and Associate Director for Basic Sciences at the Saint Louis University Cancer Center. Dr. Shilatifard earned a Ph.D. in biochemistry from the University of Georgia and the University of Oklahoma School of Medicine and completed postdoctoral training as a Jane Coffin Childs Fellow at the Oklahoma Medical Research Foundation. Research Focus: Molecular pathway of leukemogenesis.
FORM 990, PART III, LINE 4		Kausik Si, Ph.D., Assistant Investigator, joined the Stowers Institute in 2005 from the laboratory of Dr. Eric Kandel at Columbia University Center for Neurobiology and Behavior where he was a Jane Coffin Childs Fellow and a Francis Goelet Fellow in Neuroscience. Dr. Si earned a Ph.D. in molecular biology from the Albert Einstein College of Medicine. Research Focus: Role of synaptic protein synthesis in information acquisition and memory storage. Paul Trainor, Ph.D., Associate Investigator, joined the Stowers Institute in 2001 from a research position at the National Institute for Medical Research at Mill Hill, London, where he completed postdoctoral training. Dr. Trainor has a Ph.D. in developmental biology from Children's Medical Research Institute at the University of Sydney, Australia. Research Focus: Investigation of the interactions between distinct tissues in the body and their regulation during normal development to reveal pathways that regulate normal cranial and facial development. Jerry Workman, Ph.D., Investigator, joined the Stowers Institute in 2003 from the Pennsylvania State University where he held the Paul Berg Professorship of Biochemistry and was an Associate Investigator of the Howard Hughes Medical Institute. Dr. Workman earned a Ph.D. in cell and molecular biology from the University of Michigan and completed postdoctoral training at the Rockefeller University with Dr. Bob Roeder. Research Focus: Study of the protein complexes that modifY chromatin. Ting Xie, Ph.D., Investigator, joined the Stowers Institute in 2000 after completing a Howard Hughes Medical Institute postdoctoral fellowship in the laboratory of Dr. Allan C. Spradling at the Carnegie Institution of Washington. Dr. Xie received his Ph.D. from the Joint Graduate Program in Molecular Biology and Biochemistry of Rutgers University and the University of Medicine and Dentistry of New Jersey. Research Focus: Genetic and molecular analysis of stem cells and germ cell development in Drosophila and mouse. C. Ron Yu, Ph.D., Assistant Investigator, joined the Stowers Institute in 2005 from the laboratory of Dr. Richard Axel at Columbia University Center for Neurobiology and Behavior where he held a National Institutes of Health Mentored Research Scientist Award from the National Institute of Mental Health. Dr. Yu earned his Ph.D. in molecular, cellular, and biophysical studies at Columbia University. Research Focus: How olfactory sensory information is detected, integrated, and processed in the brain to irifluence specific innate behaviors. Julia Zeitlinger, Ph.D., Assistant Investigator, joined the Stowers Institute in 2007 from the lab of Dr. Richard Young at the Whitehead Institute for Biomedical Research at Massachusetts Institute of Technology where she was the recipient of a long-term postdoctoral fellowship from the Human Frontier Science Program. Dr. Zeitlinger earned a Ph.D. in molecular biology from the European Molecular Biology Laboratory in Heidelberg, Germany. Research Focus: Analysis of the gene regulatory networks underlying cellular differentiation.
FORM 990, PART III, LINE 4		Technology Centers Paul Kulesa, Ph.D., Director of Imaging, joined the Stowers Institute in 2002 after completing a Burroughs Wellcome Fund postdoctoral fellowship in the laboratory of Dr. Scott E. Fraser at the California Institute of Technology. Dr. Kulesa received a Ph.D. in applied mathematics under Dr. J.D. Murray at the University of Washington. Research Focus: Cell migration in development and cancer. Arcady Mushegian, Ph.D., Director of Bioinformatics Research, joined the Stowers Institute in 2001 from Akkadix Corporation in San Diego where he led the bioinformatics program. Dr. Mushegian earned a doctorate in molecular biology at Moscow State University and received training at the University of Kentucky, University of Washington, and with Dr. Eugene Koonin at the National Center for Biotechnology Information at the U.S. National Institutes of Health. Research Focus: Computational analysis of genes and proteins. Michael Washburn, Ph.D., Director of Proteomics, joined the Stowers Institute in 2003 from the Torrey Mesa Research Institute in San Diego where he was a Senior Staff Scientist in Proteomics. He earned a Ph.D. in biochemistry and environmental toxicology from Michigan State University before completing a postdoctoral fellowship with Professor John Yates, III in the Department of Molecular Biotechnology at the University of Washington. Research Focus: Quantitative proteomics and protein complex dynamics.

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 51056K

Schedule O (Form 990 or 990-EZ) 2010

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE R
(Form 990)

Department of the Treasury
Internal Revenue Service

Related Organizations and Unrelated Partnerships

Complete if the organization answered "Yes" to Form 990, Part IV, line 33, 34, 35, 36, or 37.
MediumBullet

Attach to Form 990. MediumBullet

See separate instructions.

OMB No. 1545-0047

2010

Open to Public Inspection

Name of the organization

Stowers Institute for Medical Research

Employer identification number

20-2993509

Part I

Identification of Disregarded Entities (Complete if the organization answered "Yes" on Form 990, Part IV, line 33.)

(a) Name, address, and EIN of disregarded entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Total income	(e) End-of-year assets	(f) Direct controlling entity

Part II

Identification of Related Tax-Exempt Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.)

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	(g) Section 512(b)(13) controlled organization
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	Yes	No
(1) STOWERS SCIENTIFIC EDUCATION INSTITUTE 1000 E 50TH STREET KANSAS CITY,MO64110 20-5916445	SUPPORT ORG	DE	501(c)(3)	11A	NA
(2) STOWERS RESOURCE MANAGEMENTINC 1000 E 50TH STREET KANSAS CITY,MO64110 41-2186719	SUPPORT ORG	DE	501(c)(3)	11a	NA
(3) BIOMED VALLEY CORPORATION 1000 E 50TH STREET KANSAS CITY,MO64110 74-3238244	SUPPORT ORG	DE	501(c)(3)	11a	NA
(4) STOWERS REAL ESTATE HOLDING CORPORATION 1000 E 50TH STREET KANSAS CITY,MO64110 26-1472230	HOLD TITLE	DE	501(c)(2)	N/A	NA

For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50135Y

Schedule R (Form 990) 2010

Page 2

Part III

Identification of Related Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.)

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code VUBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code VUBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No

Part IV

Identification of Related Organizations Taxable as a Corporation or Trust (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.)

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)
(1) BIOMED VALLEY DISCOVERIESINC 4520 MAIN ST SUITE 1650 KANSAS CITY,MO64111 06-1646533	SCI DISC DVLP	DE	NA	C

Schedule R (Form 990) 2010

Page 3

Part V

Transactions With Related Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35, 35A, or 36.)

Note. Complete line 1 if any entity is listed in Parts II, III or IV.

Yes

1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?

a Receipt of (i) interest (ii) annuities (iii) royalties (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .

Yes

b Gift, grant, or capital contribution to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

c Gift, grant, or capital contribution from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

d Loans or loan guarantees to or for other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

e Loans or loan guarantees by other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

f Sale of assets to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

g Purchase of assets from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

h Exchange of assets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

i Lease of facilities, equipment, or other assets to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .

j Lease of facilities, equipment, or other assets from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

k Performance of services or membership or fundraising solicitations for other organization(s) . . . . . . . . . . . . . . . . . . . . . .

l Performance of services or membership or fundraising solicitations by other organization(s) . . . . . . . . . . . . . . . . . . . . . .

m Sharing of facilities, equipment, mailing lists, or other assets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

n Sharing of paid employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

o Reimbursement paid to other organization for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

p Reimbursement paid by other organization for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

q Other transfer of cash or property to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

r Other transfer of cash or property from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.

(a) Name of other organization	(b) Transaction type(a-r)	(c) Amount involved
(1) BIOMED VALLEY DISCOVERIESINC	A	3,529,477
(2) BIOMED VALLEY DISCOVERIESINC	A	2,754
(3) STOWERS REAL ESTATE HOLDING CORP	J	2,230,551
(4) SEE PART VII FOR ADDITIONAL INFORMATION ON	C,F,M
(5) TRANSACTION DESCRIPTIONS	P
(6)

Schedule R (Form 990) 2010

Page 4

Part VI

Unrelated Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 37.)

Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.

(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Are all partners section 501(c)(3) organizations?		(e) Share of end-of-year assets	(f) Disproprtionate allocations?		(g) Code VUBI amount in box 20 of Schedule K-1 (Form 1065)	(h) General or managing partner?
(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	Yes	No	(e) Share of end-of-year assets	Yes	No	(g) Code VUBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No

Schedule R (Form 990) 2010

Page 5

Part VII

Supplemental Information

Complete this part to provide additional information for responses to questions on Schedule R (see instructions).

Identifier	Return Reference	Explanation
PART V, LINE 2 (1)		IN 2009 SIMR ENTERED INTO A LEASE FOR A CERTAIN BUILDING AND PROPERTY AS DESCRIBED BELOW IN (3). ALSO IN 2009, SIMR SUBLEASED ABOUT 6% OF THIS TOTAL PROPERTY TO BIOMED VALLEY DISCOVERIES, INC. ("BVD") UNTIL JULY 2010 WHEN BVD BOUGHT OUT THE REMAINDER OF THE LEASE TO MOVE TO A DIFFERENT LOCATION. AS REFLECTED ON FORM 990, PART VIII, BVD MARKET VALUE LEASE PAYMENTS TO SIMR IN 2010 TOTALED $3,529,477 INCLUDING THE LEASE BUYOUT AND SIMR HAD OFFSETTING AMOUNT OF EXPENSES FOR A PORTION OF THAT AMOUNT AS RENT PAID TO SREHC. BVD IS A CONTROLLED PARTY OF BIOMED VALLEY CORPORATION ("BVC"); BVC AND BVD ARE RELATED PARTIES OF SIMR AS REPORTED ON SCHEDULE R. THE RENT PAYMENTS FROM BVD DID NOT REDUCE BVD'S "NET UNRELATED INCOME" WITHIN THE MEANING OF CODE SECTION 512(b)(13)(A). THEREFORE, NO PORTION OF THE RENT PAYMENTS FROM BVD CONSTITUTES UNRELATED BUSINESS INCOME TO SIMR UNDER CODE SECTION 512(b)(13).
PART V, LINE 2 (2)		DURING 2010, BIOMED VALLEY DISCOVERIES, INC. ("BVD") TEMPORARILY USED OFFICE SPACE ON SIMR CAMPUS TOTALING LESS THAN 500 SQUARE FEET OF THE MORE THAN 600,000 SQUARE FEET CAMPUS. BVD PAYMENTS TO SIMR IN 2010 FOR THIS PURPOSE TOTALED $2,754. BVD IS NOW LOCATED ON A SEPARATE CAMPUS AS REPORTED IN (1) ABOVE.
PART V, LINE 2 (3)		IN MARCH 2009, SIMR ENTERED INTO A LEASE FOR A 280,000 SQUARE FEET BUILDING WITH STOWERS REAL ESTATE HOLDING CORPORATION ("SREHC"), A 501(C)(2) TAX EXEMPT ORGANIZATION THAT IS A RELATED PARTY OF SIMR. SIMR LEASE PAYMENTS TO SREHC IN 2010 TOTALED $2,230,551.
PART V, LINE 2 (4)		ALL OTHER TRANSACTIONS FOR 1(c), (f), (m), (n),(o) and (p) WERE BETWEEN RELATED 501(C)(3) PUBLIC CHARITIES OR BELOW REPORTING THRESHHOLDS.

Additional Data

Software ID:
Software Version:

1	Briefly describe the organization’s mission or most significant activities: STOWERS INSTITUTE FOR MEDICAL RESEARCH ("SIMR")EXEMPT PURPOSE IS TO PERFORM MEDICAL RESEARCH IN THE PUBLIC INTEREST WITH THE GOAL OF EXPANDING OUR UNDERSTANDING OF FUNDAMENTAL PROCESSES OF LIVING CELLS.
2	Check this box
3	Number of voting members of the governing body (Part VI, line 1a) ....	3	7
4	Number of independent voting members of the governing body (Part VI, line 1b) ....	4	0
5	Total number of individuals employed in calendar year 2010 (Part V, line 2a) ...	5	371
6	Total number of volunteers (estimate if necessary) ....	6	0
7a	Total unrelated business revenue from Part VIII, column (C), line 12 ..	7a	0
b	Net unrelated business taxable income from Form 990-T, line 34 ..	7b	0

		Prior Year	Current Year
8	Contributions and grants (Part VIII, line 1h) .........	6,592,984	8,065,484
9	Program service revenue (Part VIII, line 2g) .........	224,514	73,404
10	Investment income (Part VIII, column (A), lines 3, 4, and 7d ) ....	3,834,033	2,874,441
11	Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e)	165,218	3,391,202
12	Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)...................	10,816,749	14,404,531
13	Grants and similar amounts paid (Part IX, column (A), lines 1–3 )...	1,326,774	1,372,750
14	Benefits paid to or for members (Part IX, column (A), line 4) ....	0	0
15	Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10)	26,222,758	26,301,376
16a	Professional fundraising fees (Part IX, column (A), line 11e)....	0	0
b	Total fundraising expenses (Part IX, column (D), line 25) 0
17	Other expenses (Part IX, column (A), lines 11a–11d, 11f–24f)....	44,810,589	45,019,071
18	Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25)	72,360,121	72,693,197
19	Revenue less expenses. Subtract line 18 from line 12......	-61,543,372	-58,288,666
		Beginning of Current Year	End of Year
20	Total assets (Part X, line 16)............	565,779,280	496,643,745
21	Total liabilities (Part X, line 26)............	227,504,627	217,464,815
22	Net assets or fund balances. Subtract line 21 from line 20 .....	338,274,653	279,178,930

Sign Here

	Signature of officer	Date

	Type or print name and title.

Paid Preparer's Use Only	Preparer's signature	Date	Check if self- employed	Preparer’s taxpayer identification number (see instructions)
	Firm’s name (or yours if self-employed), address, and ZIP + 4			EIN
				Phone no.


4a	(Code: ) (Expenses $ 65,491,638 including grants of $ 1,372,750 ) (Revenue $ )
	SIMR'S ACCOMPLISHMENTS ARE DESCRIBED AT THE END OF SCHEDULE O.

4b	(Code: ) (Expenses $ including grants of $ ) (Revenue $ )












4c	(Code: ) (Expenses $ including grants of $ ) (Revenue $ )












4d	Other program services. (Describe in Schedule O.)
	(Expenses $ including grants of $ ) (Revenue $ )
4e	Total program service expenses$ 65,491,638

(A) Name and Title	(B) Average hours per week (describe hours for related organizations in Schedule O)	(C) Position (check all that apply)				(D) Reportable compensation from the organization (W- 2/1099-MISC)	(E) Reportable compensation from related organizations (W- 2/1099-MISC)	(F) Estimated amount of other compensation from the organization and related organizations
(A) Name and Title
(1) JAMES ESTOWERS JR Director	2.0	X				0	0	0
(2) VIRGINIA G STOWERS DIRECTOR	2.0	X				0	0	0
(3) DAVID AWELTE DIRECTOR/SECRETARY See Sch O	2.0	X	X			0	916,036	50,427
(4) RODERICK L STURGEON DIRECTOR - SEE SCHEDULE O	40.0	X				0	1,101,744	47,410
(5) WILLIAM B NEAVES - SEE SCH O DIRECTOR/PRESIDENT EMERITUS	40.0	X	X			701,921	0	47,158
(6) DAVID M CHAO DIRECTOR/PRESIDENT/CEO - Sch O	40.0	X	X			968,238	0	38,170
(7) RICHARD W BROWN Director/CHAIR - see sch. o	2.0	X	X			0	1,645,887	47,410
(8) ROBERT E KRUMLAUF - SEE SCH O SCIENTIFIC DIRECTOR	40.0			X		438,572	0	50,679
(9) RONALD C CONAWAY INVESTIGATOR	40.0				X	240,811	0	40,826
(10) JOAN W CONAWAY INVESTIGATOR	40.0				X	238,961	0	46,574
(11) JERRY L WORKMAN INVESTIGATOR	40.0				X	235,814	0	41,896
(12) R SCOTT HAWLEY INVESTIGATOR	40.0				X	241,854	0	49,012
(13) RONG LI INVESTIGATOR	40.0				X	226,035	0	48,695

1b	Sub-Total................
c	Total from continuation sheets to Part VII, Section A....
d	Total (add lines 1b and 1c)............	3,292,206	3,663,667	508,257

(A) Name and business address	(B) Description of services	(C) Compensation





2 Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 in compensation from the organization 0

				(A) Total revenue	(B) Related or exempt function revenue	(C) Unrelated business revenue	(D) Revenue excluded from tax under sections 512, 513, or 514
1a	Federated campaigns..1a
b	Membership dues....1b
c	Fundraising events....1c
d	Related organizations...1d		198,091
e	Government grants (contributions)1e		6,568,930

f	All other contributions, gifts, grants, and similar amounts not included above1f		1,298,463
g	Noncash contributions included in lines 1a-1f:$ 62,027
h	Total. Add lines 1a-1f.......			8,065,484
			Business Code
2a	COLLABORATION FEE FROM HHMI,501(C)(3)		900,099	73,404	73,404
b
c
d
e
f	All other program service revenue .
g	Total. Add lines 2a–2f........			73,404
3	Investment income (including dividends, interest
	and other similar amounts).....			1,670,077			1,670,077
4	Income from investment of tax-exempt bond proceeds..			0
5	Royalties............			0
		(i) Real	(ii) Personal
6a	Gross Rents	3,529,477
b	Less: rental expenses	241,909
c	Rental income or (loss)	3,287,568
d	Net rental income or (loss).......			3,287,568		0	3,287,568
		(i) Securities	(ii) Other
7a	Gross amount from sales of assets other than inventory	81,084,387	171,808
b	Less: cost or other basis and sales expenses	79,798,438	253,393
c	Gain or (loss)	1,285,949	-81,585
d	Net gain or (loss)..........			1,204,364			1,204,364
8a	Gross income from fundraising events (not including $ of contributions reported on line 1c). See Part IV, line 18 ...
	a
b	Less: direct expenses ...b
c	Net income or (loss) from fundraising events..			0
9a	Gross income from gaming activities. See Part IV, line 19 ...
	a
b	Less: direct expenses ...b
c	Net income or (loss) from gaming activities...			0
10a	Gross sales of inventory, less returns and allowances .
	a
b	Less: cost of goods sold ..b
c	Net income or (loss) from sales of inventory..			0
Miscellaneous Revenue			Business Code
11a	MO QUALITY JOBS REBATE		900,099	54,996			54,996
b	OTHER REBATES & REVENUE		900,099	48,638			48,638
c
d	All other revenue ....
e	Total. Add lines 11a–11d ......			103,634
12	Total revenue. See Instructions....			14,404,531	73,404	0	6,265,643


				(A) Beginning of year		(B) End of year
1	Cashnon-interest-bearing ..........			3,699,012	1	2,178,335
2	Savings and temporary cash investments .......				2
3	Pledges and grants receivable, net .........			720,639	3	804,237
4	Accounts receivable, net .........				4
5	Receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
	Schedule L ..........				5
6	Receivables from other disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B). Complete Part II of
	Schedule L ..........				6
7	Notes and loans receivable, net .............				7
8	Inventories for sale or use ..............			398,012	8	349,600
9	Prepaid expenses and deferred charges ............			553,403	9	631,357
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	309,180,895
b	Less: accumulated depreciation. .....	10b	119,912,525	202,127,907	10c	189,268,370
11	Investments—publicly traded securities ..........			136,133,751	11	91,175,334
12	Investments—other securities. See Part IV, line 11 ......				12
13	Investments—program-related. See Part IV, line 11 ..				13
14	Intangible assets .........				14
15	Other assets. See Part IV, line 11 ...........			222,146,556	15	212,236,512
16	Total assets. Add lines 1 through 15 (must equal line 34)...			565,779,280	16	496,643,745
17	Accounts payable and accrued expenses .			7,131,445	17	6,316,670
18	Grants payable ..........				18
19	Deferred revenue ..........				19
20	Tax-exempt bond liabilities ..........				20
21	Escrow or custodial account liability. Complete Part IV of Schedule D..				21
22	Payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
	persons. Complete Part II of Schedule L..........				22
23	Secured mortgages and notes payable to unrelated third parties ..				23
24	Unsecured notes and loans payable to unrelated third parties ....				24
25	Other liabilities. Complete Part X of Schedule D.....			220,373,182	25	211,148,145
26	Total liabilities. Add lines 17 through 25.....			227,504,627	26	217,464,815
	Organizations that follow SFAS 117, check here and complete lines 27 through 29, and lines 33 and 34.
27	Unrestricted net assets .....			338,274,653	27	279,178,930
28	Temporarily restricted net assets .....				28
29	Permanently restricted net assets .....				29
	Organizations that do not follow SFAS 117, check here and complete lines 30 through 34.
30	Capital stock or trust principal, or current funds .....				30
31	Paid-in or capital surplus, or land, building or equipment fund .....				31
32	Retained earnings, endowment, accumulated income, or other funds				32
33	Total net assets or fund balances .....			338,274,653	33	279,178,930
34	Total liabilities and net assets/fund balances .....			565,779,280	34	496,643,745