Attach to Form 990 or Form 990-EZ.
See separate instructions.| (i) Name of supported organization |
(ii) EIN |
(iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) |
(iv) Is the organization in col. (i) listed in your governing document? |
(v) Did you notify the organization in col. (i) of your support? |
(vi) Is the organization in col. (i) organized in the U.S.? |
(vii) Amount of support? |
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|---|---|---|---|---|---|---|---|---|---|
| Yes | No | Yes | No | Yes | No | ||||
| Total | |||||||||
| Calendar year(or fiscal year beginning in) | (a) 2006 | (b) 2007 | (c) 2008 | (d) 2009 | (e) 2010 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .... | ||||||
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....... | ||||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 4 | Total. Add lines 1 through 3.. | ||||||
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. | ||||||
| 6 | Public Support. Subtract line 5 from line 4. | ||||||
| Calendar year(or fiscal year beginning in) | (a) 2006 | (b) 2007 | (c) 2008 | (d) 2009 | (e) 2010 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | ||||||
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. (Explain in Part IV.) Do not include gain or loss from the sale of capital assets.. | ||||||
| 11 | Total support (Add lines 7 through 10). | ||||||






| Calendar year(or fiscal year beginning in) | (a) 2006 | (b) 2007 | (c) 2008 | (d) 2009 | (e) 2010 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose...... | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513.. | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 6 | Total. Add lines 1 through 5. | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons... | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public Support (Subtract line 7c from line 6.) | ||||||
| Calendar year (or fiscal year beginning in) | (a) 2006 | (b) 2007 | (c) 2008 | (d) 2009 | (e) 2010 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) | ||||||
| 13 | Total support (Add lines 9, 10c, 11 and 12.). | ||||||




| Facts And Circumstances Test |
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| Explanation |
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| Software ID: | 10000149 |
| Software Version: | 2010.2.15 |
Attach to Form 990 or 990-EZ.| Identifier | Return Reference | Explanation |
|---|---|---|
| Form 990 Part III | 1 | Benaroya Research Institute at Virginia Mason BRI is an international leader in immune system and autoimmune disease research translating discoveries to real life applications. BRI is one of the few research institutes in the world dedicated to finding causes and cures to eliminate autoimmune diseases including Type 1 diabetes, arthritis, lupus, multiple sclerosis, scleroderma and many others. BRI is taking a unique approach to autoimmune diseases, one in which the patients genetics and immune properties are evaluated, therapies are specifically selected for the patient and the patients immunological response is carefully monitored. BRIs research aims to block autoimmunity and to develop therapies to reverse disease by redirecting faulty immune systems so they wont attack healthy issues. |
| Form 990 Part III | 4 | Through this method, BRI expects to change the landscape of medical care options and bring therapies to patients to dramatically improve quality of life. By comparing the genetic and immunologic makeup of people with different autoimmune diseases - rheumatoid arthritis, multiple sclerosis and Type 1 diabestes in particular - BRI research teams investigate markers associated with the diseases and work to understand immune system activity. |
| Form 990 Part III | 4 continued | Immune Tolerance Network - In 2010, the National Institute of Allergy and Infectious Diseases NIAID named BRI Director Gerald T. Nepom, MD, PhD, as the Director of the Immune Tolerance Network ITN. As one of the largest government-funded clinical research networks in the country, the ITN works to establish new treatments for diseases of the immune system. The ITN has conducted studies involving 13 core laboratories and 62 clinical sites with nearly 3,000 participants enrolled under a 275 million NIAID contract in partnership with the Juvenile Diabetes Research Foundation and the National Institute of Diabetes and Digestive and Kidney Diseases. |
| Form 990 Part III | 4 continued | Profiling the Immune System - BRI launched a new Systems Immunology Division in 2010. With the explosion of data from genome studies and molecular profiling technologies, huge amounts of biological information are now available. Scientists are learning how to deal with the volume of data, developing a new field of study called Systems Immunology. It uses complex systems theory, high throughput technologies as well as mathematical and computational tools to understand the functioning of the immune system in health and disease. |
| Form 990 Part III | 4 continued | The Systems Immunology team members are developing a way to provide an immune system profile for individual patients that begins at birth and continues through a persons life, monitoring risk for immune system problems with just a simple blood test. With this profile, it is possible to envision prevention or treatment for these diseases specifically tailored to each person. |
| Form 990 Part III | 4 continued | The Translational Research Program heads efforts to develop patient profiles that combine clinical, genetic and immunological information. The scientists conduct studies with a variety of BRI registries that contain human blood and tissue samples, medical histories and other data. In recent studies, investigators have shown how slight genetic variations in people can result in profound changes in T cells and B cells both important in autoimmunity. Understanding these gene variants can help scientists determine how the immune response is altered in disease, why genes contribute to disease and what therapies will intervene in this process. |
| Form 990 Part III | 4 continued | Biomarker Expansion - During the year, BRI also expanded the use of its biomarkers to improve diagnosis and evaluate treatments in areas ranging from allergy and infectious diseases to transplantation, hemophilia, arthritis and diabetes. These biomarkers, discovered and developed at BRI, are used by researchers throughout the world. |
| Form 990 Part III | 4 continued | New Program to Study Lung Infection - Benaroya Research Institute received an 11.7 million grant in 2010 from the National Heart, Lung and Blood Institute to bring together key researchers to investigate inflammatory lung diseases. Steven Ziegler, PhD, Director of BRIs Immunology Program, leads the team of researchers from BRI and the University of Washington School of Medicine. Inflammatory diseases of the lung have a tremendous impact on people throughout the world and can leade to serious illness and death. They include influenza, pneumonia, chronic brochitis, tuberculosis and HIV/AIDS related respiratory illnesses, as well as allergic diseases such as asthma. Recent emerging lung infections include avian influenza and servere acute respiratory syndrome SARS. |
| Form 990 Part III | 4 continued | BRIs goal is to understand what drives the inflammatory response to lung infections, and then learn how best to control that response to eliminate the associated pathology. Pulmonary inflammatory diseases are immune-mediated, resulting from abnormal activity of the bodys immune system, usually in response to infection. |
| Form 990 Part III | 4 continued | Advances in Cytoprotection for Tissue Injury - In 2010, Benaroya Research Institute received a 2.8 million grant from the U. S. Department of Defense to advance work in cytoprotection for tissue injury through BRIs Center for Control of Inflammation and Tissue Repair CITR. The CITR team is developing new therapies to improve cell survival in the first hours after injury. The team also is working to generate new, engineered tissues to repair or replace tendons, ligaments, muscles and blood vessels. The new award focuses on cytoprotection, modulating immune responses to control tissue damage from inflammation. Another component of the grant is to develop a smart bandage, containing biological factors that would dampen local wound inflammation and promote healing. |
| Form 990 Part III | 4 continued | Scientists from the Hope Heart Program at BRI also made advances in tissue engineering by incorporating elastin and collagen into blood vessels, creating flexible, strong blood vessels that may eventually repair or replace those in the body. |
| Form 990 Part III | 4 continued | Scientists Study Key Factors in Autoimmune Diseases - BRI is studying critical factors in the immune system response through two new grants awarded in 2010. BRI received a 2.2 million grant from the National Institute of Allergy and Infectious Diseases NIAID to investigate a key factor, T-bet, that plays a critical role in preventing autoimmunity and limiting immune-mediated inflammation. If scientists can find a way to manipulate or program this factor, it can be used in cellular therapy to help eliminate diseases. |
| Form 990 Part III | 4 continued | NIAID also awarded BRI a nearly 1.8 million grant to study a type of cell that is an early responder in the immune system response to infection. These dendritic cells will be studied in models of lupus. This study will help scientists understand how to manipulate the immune system to achieve more efficient elimination of infections and to regulate the inflammatory response during disease. |
| Form 990 Part III | 4 continued | Clinical Research - In 2010, approximately 3,700 people joined clinical researach studies or the translational research registries at BRI. More than 100 clinical trials currently enrolling participants through BRIs Clinical Research Program CRP. Through collaboration with physicians, patients and researchers, new therapeutics are evaluated to rapidly develop medical knowledge and treatments. In 2010, the Translational Research Physicians Group was formed between clinicans at Virginia Mason Medical Center and researchers at BRI in hopes to identify the best therapy for each patient with a disease of the immune system. |
| Form 990 Part VI | 6, 7 | Virginia Mason Health System VMHS is the sole corporate member of Benaroya Research Institue at Virginia Mason. VMHS as the sole voting member has the following approval rights 1 Election and Approval of Directors and Officers of the Board of Directors 2 Removal of Directors and Officers of the Board of Directors including any executive officer of the corporation 3 Approval of all long-range plans proposed by the Board of Directors 4 Approval of the annual capital and operating budgets proposed by the Board of Directors 5 Approval of the borrowing of funds where the amount borrowed is in excess of Five Hundred Thousand Dollars 500,000 6 Approval of the sale, lease, exchange, mortgage, pledge or disposal of all or substantially all of the property and assets 7 approval of all amendments to or repeal of the Bylaws of the corporation |
| Form 990 Part VI | 6, 7 continued | 8 All other rights and powers as specified in the Washington Nonprofit Corporation Act. |
| Form 990 Part VI | 11B | Review of the Form 990 Process. The Audit and Compliance Committee ACC, a committee composed of independent community members, is responsible for oversight of the annual Form 990 preparation process including 1 selection, engagement, and review of the performance of the independent tax preparer, 2 review of the annual draft Form 990 tax return, and 3 recommendation of the final Form 990 tax return for approval to the Board of Directors. Annually, at the September meeting, management and the tax preparer provide the ACC with an inital draft of the Form 990 and present an overview of the Form 990 preparation process. The final draft Form 990 is reviewed and approved by the ACC in November followed by a Board review of the final Form 990 prior to filing. The final Form 990 tax return is provided to each member of the Board of Directors via electronic delivery. |
| Form 990 Part VI | 12C | The Governance Committee of the Board has accountability for oversight of the process for disclosure, evaluation and management of conflicts of interest involving any member of the Board, executive leadership or key employees Covered Person. Pursuant to the Conflicts of Interest Policy, an annual conflict of interest questionnaire is distributed to all Covered Persons. In addition, a Covered Person has an on-going duty to disclose the existence of a conflict of interest at any time an actual or potential conflict arises. |
| Form 990 Part VI | 12C continued | Each Covered Person is required upon appointment and annually thereafter to sign a statment that affirms that such person has 1 received a copy of the Conflicts of Interest Policy 2 has read and understands the Policy 3 has agreed to comply with the Policy and 4 understands that BRI is a charitable organization and that in order to maintain its federal tax exemption must engage in activities that accomplish its tax-exempt purposes. Written disclosures are reviewed by the Governance Committee to determine if an actual or potential conflict of interest exists and if so, how it should be managed. The Governance Committee informs the Covered Person in writing regarding the determination the Conflict of Interest Management Plan. |
| Form 990 Part VI | 12C continued | No Covered Person with an actual or potential conflict of interest shall engage in an activity on BRIs behalf related to the disclosed actual or potential Conflict of Interest unless such activity is permitted by the Conflict of Interest Management Plan or until the Covered Person has undertaken all steps set forth in the Management Plan to manage, reduce or eliminate the conflict. All Covered Persons have a duty to disclose the existence of any actual or potential conflict of interest with respect to meeting agenda items. The Conflicts of Interest Policy requires that copies of the Conflict of Interest Questionnaires be completed annually by each Covered Person and any Conflict of Interest Management Plan be maintained. |
| Form 990 Part VI | 15 | The VMHS Compensation and Benefits Board Committee, a committee composed solely of independent directors none of whom have a conflict of interest, is accountable for setting reasonable total compensation packages for each executive, officer and key employee Executive consistent with VMHS/BRIs philosophy and principles. The Board develops and approves annual goals and performance criteria which are used in determining merit increases and variable compensation opportunities. The Committee assessses performance against these goals. The Committee selects and engages a qualified independent compensation consultant to review and analyze the total compensation and benefits packages of the Executives. |
| Form 990 Part VI | 15 continued | The Committee as part of its analysis obtains from the compensation consultant appropriate comparability data including total compensation paid by similarly situated organizations for positions that are functionally comparable to each of the Executives. The Committee will consider the significant terms of the agreement with each Executive including the total compensation to be paid and the employees duties and responsibilities. Consistent with VMHS/BRIs compensation philosophy and principles, the Committee approves total compensation packages for each of the Executives based on information presented to the Committee, reasonableness and the best interest of BRI. The Committees decisions regarding compensation for each Executive are documented in written resolutions and minutes of the Committee. |
| Form 990 Part VI | 15 continued | The Commitee promptly reports its actions to the VMHS Board which reports are reflected in the Boards minutes. |
| Form 990 Part VI | 15 continued | The Executives that were reviewed in 2010 were Chief Executive Officer, Chief Operating Officer and Executive Vice President, Chief Information Officer/Chief Financial Officer and Senior Vice President, Senior Vice Presidents, Vice Presidents, Physician Chiefs, Clinic Medical Director, Hospital Medical Director, Informatics Medical Director, Quality Medical Director, Perioperative Services Medical Director, Graduate Medical Education Physician Director and Chief Scientific Officer. |
| Form 990 Part VI | 19 | The organizations Articles, Bylaws, Conflicts of Interest Policy, and financial statements are made available upon request. |
| Form 990 Part VII | 1a Column B | The estimated average hours per week devoted to a related organization are Andrew Jacobs 51 hours, Brian Chrisman 0 hours, Carla DewBerry 0 hours, Carla Greenbaum 0 hours, Dale Sperling 0 hours, Ditman Johnson 0 hours, Gary Kaplan 54 hours, Gaylia Meitzen 0 hours, George Martin 0 hours, Gerald Nepom 0 hours, Jack Almo 0 hours, Jack Nagan 0 hours, Jane Buckner 0 hours, John Corman 50 hours, Judi Rising 0 hours, Kristi Pangrazio 0 hours, Margaret Allen 0 hours, Margaret morrow 0 hours, Miriam Sevy 0 hours, Ray Heacox 0 hours, Robert Lemon 6 hours, Steven Ziegler 0 hours, Thomas Wight 0 hours, Tom Cohen 0 hours, Tom Kelly 0 hours, Trish Markey 0 hours, William Kwok 0 hours. |
| Form 990 Part XI | 5 | Net unrealized gains and losses 931,747 |
| Software ID: | 10000149 |
| Software Version: | 2010.2.15 |
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Affiliated Group Business Name:
Benaroya Research Institute at Virginia Mason
Address. Either US or Foreign Type:
1201 Ninth Avenue
Seattle, WA981012795 EIN:
91-0653422
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
0
Total Exempt Purpose Expenditures:
0
Lobbying Nontaxable Amount:
0
Grassroots Nontaxable Amount:
0
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|