Form990
Click to see attachment
Department of the Treasury
Internal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except black lung benefit trust or private foundation)

MediumBullet The organization may have to use a copy of this return to satisfy state reporting requirements.
OMB No. 1545-0047
2010
Open to Public Inspection
A For the calendar year, or tax year beginning 09-01-2010 and ending 08-31-2011
BCheck if applicable:
CName of organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Doing Business As
 
 
Number and street (or P.O. box if mail is not delivered to street address)
4000 Jones Bridge Road
 
Room/suite
City or town, state or country, and ZIP + 4
Chevy Chase, MD20815
D Employer identification number

59-0735717
E Telephone number

G Gross receipts $ 33,587,392,511
F Name and address of principal officer:
Robert Tjian PHD
4000 Jones Bridge Road
Chevy Chase,MD20815
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
hhmi.org
H(a)
Is this a group return for
affiliates?
H(b)
Are all affiliates included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:
 
L Year of formation: 1953
M State of legal domicile: DE
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: The Howard Hughes Medical Institute is a philanthropy that serves society through the direct conduct of biomedical research and support for programs in science education.
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) .... 3 11
4 Number of independent voting members of the governing body (Part VI, line 1b) .... 4 10
5 Total number of individuals employed in calendar year 2010 (Part V, line 2a) ... 5 3,645
6 Total number of volunteers (estimate if necessary) .... 6  
7a Total unrelated business revenue from Part VIII, column (C), line 12 .. 7a 11,826,482
b Net unrelated business taxable income from Form 990-T, line 34 .. 7b  
Revenues; Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 0 0
9 Program service revenue (Part VIII, line 2g) ......... 0 1,252,708
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 359,726,783 1,036,998,849
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 8,290,137 8,481,921
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)................... 368,016,920 1,046,733,478
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 111,771,312 22,826,292
14 Benefits paid to or for members (Part IX, column (A), line 4) .... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 420,392,341 359,525,011
16a Professional fundraising fees (Part IX, column (A), line 11e).... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet0    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24f).... 541,991,420 601,296,308
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 1,074,155,073 983,647,611
19 Revenue less expenses. Subtract line 18 from line 12...... -706,138,153 63,085,867
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............ 16,803,128,883 18,237,793,953
21 Total liabilities (Part X, line 26)............ 2,373,583,346 2,497,927,817
22 Net assets or fund balances. Subtract line 21 from line 20 ..... 14,429,545,537 15,739,866,136
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title.
Paid Preparer's Use Only Preparer's
signatureBig Right Arrow 		Date
right pointing bullet image Preparer’s taxpayer identification number
(see instructions)
Firm’s name (or yours
if self-employed),
address, and ZIP + 4Big Right Arrow




 		EIN right pointing bullet image
Phone no. right pointing bullet image
May the IRS discuss this return with the preparer shown above? (see instructions) .........
For Privacy Act and Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y
Form 990 (2010)
Form 990 (2010)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response to any question in this Part III . . . . . . . . . .
1
Briefly describe the organization’s mission: THE INSTITUTE'S CHARTER STATES: "THE PRIMARY PURPOSE AND OBJECTIVE OF THE HOWARD HUGHES MEDICAL INSTITUTE SHALL BE THE PROMOTION OF HUMAN KNOWLEDGE WITHIN THE FIELD OF BASIC SCIENCES (PRINCIPALLY THE FIELD OF MEDICAL RESEARCH AND MEDICAL EDUCATION) AND THE EFFECTIVE APPLICATION THEREOF FOR THE BENEFIT OF MANKIND."
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ....................
If “Yes,” describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program services? ..........................
If “Yes,” describe these changes on Schedule O.
4
Describe the exempt purpose achievements for each of the organization’s three largest program services by expenses.
Section 501(c)(3) and 501(c)(4) organizations and section 4947(a)(1) trusts are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 730,722,217 including grants of $   ) (Revenue $   )
TABLE OF CONTENTS - LINE 4a (A) The HHMI Investigator Program (B) HHMI-GBMF Investigator Program (C) International Early Career Scientist Program (D) New Open Access Journal (E) Janelia Farm Research Campus (F) The HHMI Early Career Scientist Program (G) Medical Research Training (H) Highlights from HHMI Research Laboratories (Fiscal Year 2011) (I) Honors and Awards Received by HHMI Scientists (A) The HHMI Investigator Program The Howard Hughes Medical Institute's approach to biomedical research can be summarized in three words: people, not projects. By appointing scientists as HHMI investigators - rather than awarding research grants - the Institute provides long-term, flexible support that enables its researchers to pursue their scientific interests wherever they lead. HHMI believes that scientists of exceptional talent and imagination will make fundamental discoveries of lasting scientific value and benefit to humanity if they are given the resources, time, and freedom to pursue challenging questions. The Institute nurtures the creativity and intellectual daring of scientists who are willing to set aside conventional wisdom or the "easy" question for a fundamental problem that may take many years to solve. Among the characteristics that distinguish this group of scientists are qualities such as creativity, a penchant for risk-taking, and a commitment to discovery, productivity, and perseverance. This unique research model is an imaginative and powerful alternative to funding biomedical research through grants. Through its flagship Investigator Program, HHMI employs more than 379 HHMI researchers who lead over two thousand other HHMI laboratory personnel in Institute research laboratories on the campuses of 72 universities and other research organizations throughout the United States. HHMI counts among its ranks 13 Nobel laureates-nine of whom received their Nobel Prizes in the last decade alone-and 147 members of the National Academy of Sciences. Since the early 1990s, HHMI investigators have been selected through rigorous national competitions. Beginning in 2006, the Institute began soliciting applications directly from scientists at medical schools and other research institutions in the United States, with the aim of identifying those who have the potential to make significant contributions to science. HHMI employs an open application process to ensure that it is selecting its researchers from a broad and deep pool of scientific talent. Once selected, HHMI investigators continue to be based at their home institutions, typically leading a research group of 10-25 postdoctoral associates, students, and research technicians, but the investigators become Institute employees and receive administrative support from HHMI field staff throughout the country. With freedom and flexibility come high expectations for intellectual output. HHMI demands creativity and innovation. Investigators are expected to work at the frontiers of their chosen field, to ask fundamental questions, and to take risks. HHMI prizes impact over publication volume in its merit-based renewal of investigator appointments and recognizes that some areas of research will proceed more slowly than others. The renewal of an investigator's five-year appointment with HHMI is dependent on a rigorous peer-review process that centers on an evaluation of the originality and creativity of the investigator's work relative to others in the field, as well as the investigator's plan for future research. Those investigators whose appointments are not renewed remain HHMI employees for multi-year phase-out periods to facilitate their ability to obtain other funding for their research. A summary of research highlights and related information is attached. (B) HHMI-GBMF Investigator Program HHMI collaborated in 2011 with the Gordon and Betty Moore Foundation (GBMF), a California-based foundation focused on fundamental research outside biomedicine and environmental conservation, in an effort to highlight the critical importance of plant science research. Basic research in this area has long been underfunded in the United States, despite the central role plants play in maintaining human health. The two organizations held a nationwide competition and, at a meeting in April 2011, identified 15 innovative plant biologists as the first HHMI-GBMF investigators. Like other HHMI investigators, the HHMI-GBMF investigators become HHMI employees at the time of their appointment. The 15 HHMI-GBMF investigators are based at 13 different institutions throughout the country and they are leaders in a variety of fields. Many have dedicated their careers to the study of plants, captivated early on by the symmetry of a flower or the efficient transformation of sunlight to energy. Others are immunologists, developmental biologists, and geneticists who-like HHMI-welcomed plants into their research programs because they offer unique opportunities to address the questions the scientists considered most important. (C) International Early Career Scientist Program Announced HHMI announced in late 2010 that it would commit $24 million to help up to 35 international early career scientists establish independent research programs. The program is designed to complement HHMI's 2008 initiative supporting 50 early career scientists in the United States. The awards will support scientists who have trained in the United States at the graduate, medical school, or postdoctoral level; have run their own labs for fewer than seven years; and work on biomedical research in a university or nonprofit research institution in one of 18 eligible countries: Argentina, Brazil, Chile, China, Czech Republic, Egypt, Hungary, India, Italy, Mexico, Poland, Portugal, Russia, South Africa, South Korea, Spain, Taiwan, and Turkey. Finalists traveled to HHMI's Janelia Farm Research Campus to make scientific presentations in late 2011 and the awardees will be announced in early 2012. (D) New Open Access Journal HHMI, the Max Planck Society, and the Wellcome Trust announced plans to establish a new, top tier scientific journal called eLife. The journal, which will follow an open access model and be directed by practicing scientists, will be managed by an independent entity with its own board of directors. It is expected to begin publication in 2012. (E) Janelia Farm Research Campus The Janelia Farm Research Campus, open since 2006, offers a collaborative research environment for scientists across an array of disciplines who have focused on two broad scientific areas of scientific inquiry: the identification of general principles governing how neuronal circuits process information and development of imaging technologies and computational methods that support image analysis. It houses 47 laboratory groups, in addition to supporting graduate students and other scientific trainees, visiting scientists, and a vibrant conference program. (F) The HHMI Early Career Scientist Program In 2009, HHMI initiated a research program to support a small group of Early Career Scientists. To date, 50 Early Career Scientists have received six-year appointments. Each scientist becomes an Institute employee and receives sufficient financial support to enable them to pursue challenging scientific problems. HHMI's investment of approximately $200 million is allowing these researchers to concentrate on making discoveries in the laboratory and training the next generation of scientists. The scientists, who are at 33 institutions across the United States, have made considerable contributions to biomedical research. Energetic and passionate about a broad range of scientific questions, this group of scientists is at a career stage that many consider to be a scientist's most productive-and most vulnerable. HHMI provides each Early Career Scientist with his or her full salary, benefits, and a research budget of $1.5 million over the six-year appointment. HHMI also covers other expenses, including research space and the purchase of critical equipment. (G) Medical Research Training With the National Institutes of Health, HHMI selected 48 medical, dental, and veterinary students who are taking a year off from professional school to engage in laboratory research at the NIH campus in Bethesda through the HHMI-NIH Research Scholars Program. HHMI will transition out of financially supporting this program after the 2011-2012 class, and the program will become fully supported by the NIH; HHMI will continue to collaborate with the NIH to provide unique training elements to program participants. Since 1985, the program has enabled about 1,000 students to conduct research in NIH labs. (H) continued on Schedule O
4b (Code:   ) (Expenses $ 34,689,816 including grants of $ 22,136,292 ) (Revenue $   )
TABLE OF CONTENTS - LINE 4b (A) Graduate Science Education (B) Precollege and Undergraduate Science Education Program (C) Educational Resources (D) HHMI Launches Documentary Film Production Unit HHMI's Department of Science Education emphasizes initiatives with the power to transform graduate, undergraduate, and precollege education in the life sciences. HHMI is the largest private funder of science education in the United States. During the fiscal year, the Institute distributed $80 million in grants to support science education. The Institute's science education programs support ties between scientific research and teaching with the goal of increasing and enhancing student research opportunities; improving science courses, curricula, and instruction; and providing enhanced graduate and medical training opportunities. Most HHMI grants are awarded through competitions with specific objectives and eligibility criteria and awards are generally made following a stringent process of peer review. HHMI does not encourage and rarely funds unsolicited grant proposals. HHMI's educational activities are funded through three major programs; the goals of each program and the major activities for the year are summarized below. (A) Graduate Science Education This program focuses on the development of innovative graduate education programs through grants to institutions. It also supports research fellowships for medical students, doctoral fellowships for students who are disadvantaged or from groups underrepresented in the sciences, and research grants to physician-scientists at the outset of their careers as independent scientists. Activity included: Selection of 48 exceptionally talented graduate students from 22 countries as recipients of the first International Student Research Fellowships. This support will enable these individuals to devote their full attention to research during their third, fourth, and fifth year of graduate school. HHMI chose to start this program-a $2 million commitment in its first year-because it recognized a problem: International students in U.S. graduate schools often have difficulty getting funding to support their studies, despite their talent and promise. For example, they are not eligible for federal education and training grants, state scholarships, or other stipends that are reserved only for U.S. citizens. Selection of 72 medical, dental, and veterinary students as part of HHMI's Medical Research Fellows Program. The fellowships enable students to take a year off from professional school to conduct laboratory research. The hope is that these students will one day choose to work at the crossroads of basic and clinical research. To expand the program, HHMI has entered into partnerships with several foundations that fund students who have specific research interests. This year, the Foundation Fighting Blindness (FFB, www.FightBlindness.org) is funding three medical students who are conducting research on causes and therapeutic approaches related to age-related macular degeneration and Stargardt disease. FFB supports research that will lead to preventions, treatments, and cures for degenerative diseases of the retina, and this is the second year it has collaborated with HHMI to support student research. HHMI also has partnerships with the Burroughs Wellcome Fund to support fellowships for veterinary students and the GM Trust to fund students studying Duchenne muscular dystrophy, though neither funded students this year. Selection of 10 promising students as recipients of Gilliam Fellowships for Advanced Study. The fellowships provide full support for up to five years of study toward a Ph.D. in the sciences to students who are disadvantaged or who come from groups underrepresented in the sciences. The Gilliam Fellows Program, which is now in its sixth year, aims to enrich science research and increase the diversity of college and university science faculty. Fellowship recipients participated in HHMI's Exceptional Research Opportunities Program (EXROP), which provides summer research experiences in HHMI laboratories. (B) Precollege and Undergraduate Science Education Program Through this program, HHMI seeks to recruit and develop the future leaders of science and enhance science literacy among all students. Precollege grants support teacher training and inquiry-based student learning. Grants to colleges and universities support undergraduate student research, faculty and curriculum development, and science education outreach activities. Through the HHMI professors program, HHMI provides support to distinguished scientists with a commitment to teaching. In the 2011 fiscal year: HHMI brought together four universities with an ambitious goal: create and share effective models for teaching interdisciplinary science, including new courses and ways of assessing how well they work. Together, Purdue University, the University of Maryland, Baltimore County, the University of Maryland, College Park, and the University of Miami will work collaboratively to develop competency-based undergraduate curricula that build connections across the science disciplines as part of the four-year $1.8 million NEXUS or National Experiment in Undergraduate Science Education. Twelve new schools joined HHMI's Science Education Alliance (SEA) and will offer their undergraduate students an opportunity to experience discovery first hand through a year-long research course. Another 14 schools will participate as associate members. HHMI committed $4 million over four years to supporting the National Genomics Research Initiative for faculty and student support. The two-part, year-long course enables students to make real discoveries by doing research on bacterial viruses, called phage. A total of 80 college students were selected to participate in HHMI's Exceptional Research Opportunities Program (EXROP). The EXROP program provides summer research experiences in the labs of HHMI investigators, professors, and at the Janelia Farm Research Campus. Now in its eighth year, the EXROP program is designed to encourage the students to pursue careers in science. A total of $3 million in new funding from HHMI was used to scale up a successful summer program that aims to enable thousands of college and university science faculty to receive intensive professional development designed to improve undergraduate biology education. The grant enables expansion of the National Academies Summer Institute for Undergraduate Education in Biology from a single location at the University of Wisconsin, Madison, to a total of nine regional centers over the next five years. Several of the new Summer Institute sites debuted in Summer 2011 in New Haven, Boulder, Minneapolis, and Olympia, Washington. (C) Educational Resources This program produces science education materials that feature some of the cutting-edge research conducted by HHMI investigators and other scientists. The materials are designed primarily for the nation's high school biology students and their teachers, but they also find an audience among the general public and undergraduate-level students and educators. The 2010 Holiday Lectures on Science featured two of the nation's preeminent biologists who discussed, "Viral Outbreak: The Science of Emerging Disease." Eva Harris, a professor at the University of California, Berkeley, and Joseph DeRisi, an HHMI investigator at the University of California, San Francisco, delivered their lectures live to an audience of nearly 200 high school students. Those lectures are later made available to a national and international audience through the distribution of free DVDs and the development of accompanying teaching materials. Each year, more than 100,000 copies of the DVDs are distributed; the supporting website receives more than two million visits each year. (D) HHMI Launches Documentary Film Production Unit In support of its mission to improve science education, HHMI this year launched a documentary film initiative that aims to bring high-quality, compelling educational science features to television and museum theaters. HHMI plans to spend approximately $60 million on this initiative over the next five years. Because the goal of the initiative is to enhance education about all fields of science, film productions are expected to cover the broad spectrum of science, from biology to paleontology, from cosmology to archaeology, and from physics to earth science. A series of short-form films and materials for science educators at the high school and college level will be produced in tandem with full-length documentary films and other new media content. Michael Rosenfeld, an award-winning documentary producer and former president of National Geographic Television, is leading the documentary film initiative.
4c (Code:   ) (Expenses $ 16,526,734 including grants of $ 690,000 ) (Revenue $   )
(A) International Research Scholars Program The HHMI International Research Scholars Program seeks to support individual scientists of the highest quality in their home countries and to join them with each other and with other scientists in the HHMI community to create an international network of scientific excellence. HHMI's commitment to international science began 18 years ago with an initial program focused on Canada and Mexico. The Institute provides grants to 104 international research scholars with a focused program on infectious and parasitic diseases. Currently, HHMI supports scientists working in Argentina, Australia, Brazil, Canada, Chile, China, Croatia, Czech Republic, Denmark, Estonia, France, Germany, Hungary, India, Israel, Lithuania, Mali, Mexico, Poland, Portugal, Russia, Slovakia, South Africa, Spain, Switzerland, Thailand, Uruguay, and Venezuela. HHMI supports periodic scientific workshops and laboratory courses that are held outside the United States at the home institutions of HHMI's international research scholars. The courses are intended to help build an infrastructure for biomedical research in the regions where the scholars work, as well as to strengthen the exchange of information between the United States and the international scientific community. The International Research Scholars Program will be phased out at the end of calendar 2011. (B) The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) HHMI, in collaboration with the University of KwaZulu-Natal (UKZN) in South Africa, has established an international research center focused on making major scientific contributions to the worldwide effort to control the devastating co-epidemic of tuberculosis and HIV. The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) is placing a major emphasis on helping to develop and train a new generation of scientists in Africa. HHMI has committed $60 million to K-RITH over the next 10 years. K-RITH will be housed on the campus of the Nelson R. Mandela School of Medicine in Durban in a new facility (currently in construction) that includes high-level biosafety (BSL-3) laboratories equipped for TB research. HHMI, UKZN and LIFE Lab, a biotechnology center of the government of South Africa, are making substantial commitments for the project. The need for more research on TB and HIV is compelling. South Africa has more residents infected with HIV than any other nation in the world. By 2007, the nation accounted for 17 percent of the global HIV disease burden- an estimated 5.4 million people are infected - and it has one of the highest per capita rates of tuberculosis in the world. Tuberculosis, a major problem in the pre-AIDS South Africa, emerged as a public health crisis in its own right, particularly with the emergence of both multi-drug resistant (MDR) and extensively drug resistant (XDR) strains of tuberculosis in persons already infected with HIV. KwaZulu-Natal province, home to more than 10 million people, bears an even greater burden of disease than the nation as a whole and as much as 40 percent of the population may be positive for HIV. In fall 2010, K-RITH began recruiting early career and established research scientists, in addition to awarding grants to support collaborative research and educational activities between South African scientists and their international colleagues. In July 2011, South African dignitaries as well as scientists from around the world gathered in Durban to celebrate the groundbreaking of K-RITH. The groundbreaking ceremony was followed by a three-day scientific symposium featuring talks by researchers from Africa, Europe, and the United States who highlighted both the challenges and opportunities of researching TB and HIV where they are so prevalent. Scientific laboratories at K-RITH should be operational within a year.
4d Other program services. (Describe in Schedule O.)
(Expenses $   including grants of $   ) (Revenue $   )
4e Total program service expensesMediumBullet$ 781,938,767
Form 990 (2010)
Form 990 (2010)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If “Yes,” complete Schedule AClick to see attachment.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors? ........
2
 
No
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If “Yes,” complete Schedule C, Part IClick to see attachment..........
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities? If “Yes,” complete Schedule C,
Part IIClick to see attachment.........................
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If “Yes,” complete Schedule C, Part III........................
5
 
 
6
Did the organization maintain any donor advised funds or any similar funds or accounts where donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If “Yes,” complete
Schedule D, Part IClick to see attachment.......................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas or historic structures? If “Yes,” complete Schedule D, Part IIClick to see attachment...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If “Yes,” complete Schedule D, Part III Click to see attachment....................
8
 
No
9
Did the organization report an amount in Part X, line 21; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If “Yes,”
complete Schedule D, Part IVClick to see attachment...................
9
 
No
10
Did the organization, directly or through a related organization, hold assets in term, permanent,or quasi-endowments? If “Yes,” complete Schedule D, Part VClick to see attachment
10
 
No
11
If the organization’s answer to any of the following questions is ‘Yes,’ then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable:
a
Did the organization report an amount for land, buildings, and equipment in Part X, line10? If “Yes,” complete Schedule D, Part VI.Click to see attachment
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VII.Click to see attachment
11b
Yes
 
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIII.Click to see attachment
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part IX.Click to see attachment
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If “Yes,” complete Schedule D, Part X.Click to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If “Yes,” complete Schedule D, Part X.Click to see attachment
11f
 
No
12a
Did the organization obtain separate, independent audited financial statements for the tax year? If “Yes,” complete Schedule D, Parts XI, XII, and XIII Click to see attachment
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If “Yes,” and if the organization answered ‘No’ to line 12a, then completing Schedule D, Parts XI, XII, and XIII is optional Click to see attachment
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If “Yes,” complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States?....
14a
Yes
 
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, and program service activities outside the United States? If “Yes,” complete Schedule F, Part I......... Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or assistance to any organization or entity located outside the U.S.? If “Yes,” complete Schedule F, Part II.. Click to see attachment
15
Yes
 
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or assistance to individuals located outside the U.S.? If “Yes,” complete Schedule F, Part III.. Click to see attachment
16
Yes
 
17
Did the organization report a total of more than $15,000, of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If “Yes,” complete Schedule G, Part I
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If “Yes,” complete Schedule G, Part II..........
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If “Yes,” complete Schedule G, Part III...................
19
 
No
Form 990 (2010)
Form 990 (2010)
Page 4
Part IV
Checklist of Required Schedules (continued)
20a
Did the organization operate one or more hospitals? If “Yes,” complete Schedule H.....
20a
 
No
b
Did the organization attach its audited financial statement to this return? Note: All Form 990 filers that operate one or more hospitals must attach audited financial statements. .....
20b
 
 
21
Did the organization report more than $5,000 of grants and other assistance to governments and organizations in the United States on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II.. Click to see attachment
21
Yes
 
22
Did the organization report more than $5,000 of grants and other assistance to individuals in the United States on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III..... Click to see attachment
22
Yes
 
23
Did the organization answer “Yes” to Part VII, Section A, questions 3, 4, or 5, about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If “Yes,” complete Schedule J................ Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer questions 24b–24d and complete Schedule K. If “No,” go to line 25................ Click to see attachment
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds?......................
24c
 
No
d
Did the organization act as an “on behalf of” issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3) and 501(c)(4) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If “Yes,” complete Schedule L, Part I...... Click to see attachment
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If “Yes,” complete Schedule L, Part I................ Click to see attachment
25b
 
No
26
Was a loan to or by a current or former officer, director, trustee, key employee, highly compensated employee, or disqualified person outstanding as of the end of the organization’s tax year? If “Yes,” complete Schedule L,
Part II........................... Click to see attachment
26
 
No
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor, or a grant selection committee member, or to a person related to such an individual? If “Yes,” complete Schedule L, Part III............... Click to see attachment
27
 
No
28
Was the organization a party to a business transaction with one of the following parties? (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If “Yes,” complete Schedule L, Part IV ......................... Click to see attachment
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If “Yes,”
complete Schedule L, Part IV................... Click to see attachment
28b
 
No
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or owner? If “Yes,” complete Schedule L, Part IV.. Click to see attachment
28c
Yes
 
29
Did the organization receive more than $25,000 in non-cash contributions? If “Yes,” complete Schedule M
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If “Yes,” complete Schedule M............
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If “Yes,” complete Schedule N,
Part I...........................
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If “Yes,” complete Schedule N, Part II.......................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If “Yes,” complete Schedule R, Part I........ Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If “Yes,” complete Schedule R, Parts II, III, IV, and V, line 1..................... Click to see attachment
34
Yes
 
35
Is any related organization a controlled entity within the meaning of section 512(b)(13)? .....
35
Yes
 
a
Did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If “Yes,” complete Schedule R, Part V, line 2... Click to see attachment
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If “Yes,” complete Schedule R, Part V, line 2........... Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If “Yes,” complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11 and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2010)
Form 990 (2010)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response to any question in this Part V . . . . . . . . . .
Yes
No
1a
Enter the number reported in Box 3 of Form 1096. Enter -0- if not applicable. .......
1a
961
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable.
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and Tax Statements filed for the calendar year ending with or within the year covered by this return .....................
2a
3,645
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?

Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file. (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?.............................
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No,” provide an explanation in Schedule O.....
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account or securities account)?.......................
4a
Yes
 
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for Form TD F 90-22.1, Report of Foreign Bank and Financial Accounts.
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year?..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If “Yes” to line 5a or 5b, did the organization file Form 8886-T? ........
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible?..........
6a
 
No
b
If “Yes,” did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible?........................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor?....................
7a
 
No
b
If “Yes,” did the organization notify the donor of the value of the goods or services provided?.....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282?...........................
7c
 
No
d
If “Yes,” indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?..........................
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract?..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?...................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C?...............
7h
 
 
8
Sponsoring organizations maintaining donor advised funds and section 509(a)(3) supporting organizations. Did the supporting organization, or a donor advised fund maintained by a sponsoring organization, have excess business holdings at any time during the year?................
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the organization make any taxable distributions under section 4966?.........
9a
 
 
b
Did the organization make a distribution to a donor, donor advisor, or related person?......
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If “Yes,” enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. All 501(c)(29) organizations must list in Schedule O each state in which they are licensed to issue qualified health plans, the amount of reserves required by each state, and the amount of reserves the organization allocated to each state.
13a
 
 
b
Enter the aggregate amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans.
13b
 
c
Enter the aggregate amount of reserves on hand.
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
 
b
If "Yes," has it filed a Form 720 to report these payments? If “No,” provide an explanation in Schedule O..
14b
 
 
Form 990 (2010)
Form 990 (2010)
Page 6
Part VI
Governance, Management, and Disclosure For each “Yes” response to lines 2 through 7b below, and for a “No” response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response to any question in this Part VI . . . . . . . . . .
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year ..............
1a
11
b
Enter the number of voting members included in line 1a, above, who are independent .................
1b
10
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
Yes
 
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? ..
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed?
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Does the organization have members or stockholders? ................
6
 
No
7a
Does the organization have members, stockholders, or other persons who may elect one or more members of the governing body? .........................
7a
 
No
b
Are any decisions of the governing body subject to approval by members, stockholders, or other persons? ..
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .........................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If “Yes,” provide the names and addresses in Schedule O .....
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal
Revenue Code.)
Yes
No
10a
Does the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If “Yes,” does the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with those of the organization? ....
10b
 
 
11a
Has the organization provided a copy of this Form 990 to all members of its governing body before filing the form?
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review the Form 990. .....
12a
Does the organization have a written conflict of interest policy? If “No,” go to line 13.......
12a
Yes
 
b
Are officers, directors or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ...........................
12b
Yes
 
c
Does the organization regularly and consistently monitor and enforce compliance with the policy? If “Yes,” describe in Schedule O how this is done ....................
12c
Yes
 
13
Does the organization have a written whistleblower policy? ...............
13
 
No
14
Does the organization have a written document retention and destruction policy? .........
14
 
No
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line a or b, describe the process in Schedule O. (See instructions.)
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If “Yes,” has the organization adopted a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and taken steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
AK , AZ , CA , IL , IN , MD , MA , NY , OK , OR
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you make these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how), the organization makes its governing documents, conflict of interest policy, and financial statements available to the public.
20
State the name, physical address, and telephone number of the person who possesses the books and records of the organization: MediumBullet
NITIN V KOTAK
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
(301) 215-8500
Form 990 (2010)
Form 990 (2010)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response to any question in this Part VII . . . . . . . . . .
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation, and current key employees. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organizations compensated any current or former officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (describe hours for related organizations in Schedule O) 		(C)
Position (check all that apply) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(1) James A Baker III Esq
Trustee
 2.0 X           40,000   0
(2) Charlene Barshefsky Esq
Trustee
 2.0 X           40,000   0
(3) Joseph L Goldstein MD
Trustee
 2.0 X           42,750   0
(4) Hanna H Gray PhD
Trustee
 2.0 X           46,666   0
(5) Garnett L Keith
Trustee, Chairman Finance Comm
 4.0 X           50,000   0
(6) Paul M Nurse PhD
Trustee
 2.0 X           40,000   0
(7) Alison M Richard PhD
Trustee, Chairman Ed&Intl Comm
 2.0 X           50,000   0
(8) Clayton S Rose PhD
Trustee, Chairman Audit & Comp
 6.0 X           50,000   0
(9) Kurt L Schmoke Esq
Trustee, Chairman
 6.0 X           53,333   0
(10) Anne M Tatlock
Trustee
 2.0 X           40,000   0
(11) Fred R Lummis
Trustee
 2.0 X           40,000   0
(12) Robert Tjian PhD
President
 40.0     X       1,082,706 0 60,364
(13) Craig A Alexander Esq
VP, General Counsel&Secretary
 40.0     X       565,603   53,133
(14) Sean B Carroll PhD
VP for Science Educ. eff 9/10
 40.0     X       315,471   46,767
(15) Jack E Dixon PhD
VP & Chief Scientific Officer
 40.0     X       732,783   61,638
(16) Mohamoud Jibrell
VP for Information Technology
 40.0     X       225,636   43,864
(17) Avice A Meehan
VP, Communications&Public Aff
 40.0     X       411,308   41,113
Form 990 (2010)
Form 990 (2010)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (describe hours for related organizations in Schedule O) 		(C)
Position (check all that apply) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(18) Edward J Palmerino
VP Finance&Treasurer thru 2/11
 40.0     X       357,710   48,064
(19) Gerald M Rubin PhD
VP & Director, Janelia Farm
 40.0     X       678,146   123,571
(20) Landis Zimmerman
VP & Chief Investment Officer
 40.0     X       1,080,911   53,556
(21) Robert C Mullins
Controller
 40.0     X       239,643   52,460
(22) Heidi E Henning Esq
Deputy Gen. Counsel & Asst Sec
 40.0     X       399,266   54,190
(23) Cheryl A Moore
Executive VP & COO eff 9/10
 40.0     X       638,820   45,589
(24) Susan S Plotnick
Assistant Treasurer
 40.0     X       217,872   44,008
(25) Nitin V Kotak
VP, CFO & Treasurer - eff.2/11
 40.0     X       0   0
(26) Richard A Pender
Man. Dir. - US Equities
 40.0       X     805,874   52,913
(27) Robert J Kolyer Jr
Man. Dir. - Absolute Return
 40.0       X     615,377   46,327
(28) Stephen M Kitsoulis
Man. Dir. - Fixed Income
 40.0       X     574,215   48,557
(29) Mark A Barnard
Man. Dir. - Private Equities
 40.0       X     486,090   58,645
(30) Eric R Kandel MD
Senior Investigator
 40.0         X   540,352   69,836
(31) Anil Madhok
Man. Dir. - Investments - COO
 40.0         X   518,771   46,888
(32) Matthew R Lee
Man. Dir. - Portfolio Strategy
 40.0         X   502,314   46,091
(33) Gunter Blobel MD PhD
Investigator
 40.0         X   433,891   88,861
(34) Richard Axel MD
Investigator
 40.0         X   428,030   44,378
(35) Thomas R Cech PhD
Investigator
 40.0           X 953,456   46,748
(36) Joseph D Collins
VP - Information Technology
 0.0           X 220,832   31,623
(37) David A Clayton PhD
Group Leader
 40.0           X 109,086   37,607
(38) Peter J Bruns PhD
VP Grants & Special Programs
 40.0           X 457,828   46,819
1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)............MediumBullet 14,084,740 0 1,393,610
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 in reportable compensation from the organizationMediumBullet638
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If “Yes,” complete Schedule J for such individual .............
3
Yes
 
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If “Yes,” complete Schedule J for such individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If “Yes,” complete Schedule J for such person .....
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
Echo Street Capital MgtLLCVia HHM
850 Third Avenue
NEW YORK,NY10022 		Investment Mgt 8,678,200
Bridgewater AssocIncvia HHMI XVI
1 GLENDINNING PLACE
WESTPORT,CT06880 		Investment Mgt 8,325,311
WS Capital Mgt advisor to HHMI LP
300 Crescent Court Suite 1111
DALLAS,TX75201 		Investment Mgt 5,696,055
Intellectual Ventures
1756 114th Avenue SE Suite 110
BELLEVUE,WA98004 		Investment Mgt 4,687,500
Belltower Advisors LLC via HHMI V
220 Horizon Drive Suite 121
RALEIGH,NC27615 		Investment Mgt 4,432,184
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 in compensation from the organization MediumBullet138
Form 990 (2010)
Form 990 (2010)
Page 9
Part VIII
Statement of Revenue
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512, 513, or 514
Contributions, gifts, grants and other similar amounts 1a Federated campaigns..1a  
b Membership dues....1b  
c Fundraising events....1c  
d Related organizations...1d  
e Government grants (contributions)1e  
f All other contributions, gifts, grants, and
similar amounts not included above1f 		 
g Noncash contributions included in lines 1a-1f:$  
h Total. Add lines 1a-1f.......MediumBullet 0
Program Service Revenue Business Code
2a RENTAL INCOME 900,099 1,252,708 1,252,708    
b
c
d
e
f All other program service revenue .        
g Total. Add lines 2a–2f........MediumBullet 1,252,708
Other Revenue 3 Investment income (including dividends, interest
and other similar amounts).....MediumBullet 282,070,507   12,612,437 269,458,070
4 Income from investment of tax-exempt bond proceeds..MediumBullet 8,514     8,514
5 Royalties............MediumBullet 8,806,547     8,806,547
(i) Real (ii) Personal
6a Gross Rents 1,242,874  
b Less: rental expenses 2,066,835  
c Rental income or (loss) -823,961  
d Net rental income or (loss).......MediumBullet -823,961   -785,955 -38,006
(i) Securities (ii) Other
7a Gross amount from sales of assets other than inventory 33,293,512,026  
b Less: cost or other basis and sales expenses 32,538,592,198  
c Gain or (loss) 754,919,828  
d Net gain or (loss)..........MediumBullet 754,919,828     754,919,828
8a Gross income from fundraising events (not including
$  
of contributions reported on line 1c). See Part IV, line 18 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from fundraising events..MediumBullet 0    
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities...MediumBullet 0      
10a Gross sales of inventory, less
returns and allowances .
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet 0      
Miscellaneous Revenue Business Code
11a INVESTMENT EXPENSE REBATE 900,099 218,950     218,950
b CAFETERIA INCOME 900,099 199,890     199,890
c PROCEEDS FROM INSURANCE LOSS 900,099 21,998     21,998
d All other revenue .... 58,497     58,497
e Total. Add lines 11a–11d ......MediumBullet 499,335
12 Total revenue. See Instructions....MediumBullet 1,046,733,478 1,252,708 11,826,482 1,033,654,288
Form 990 (2010)
Form 990 (2010)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A) but are not required to complete columns (B), (C), and (D).
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to governments and organizations in the U.S. See Part IV, line 21 13,276,715 13,276,715
2 Grants and other assistance to individuals in the U.S. See Part IV, line 22 8,859,577 8,859,577
3 Grants and other assistance to governments, organizations, and individuals outside the U.S. See Part IV, lines 15 and 16 690,000 690,000
4 Benefits paid to or for members 0  
5 Compensation of current officers, directors, trustees, and key employees .... 13,181,480 3,375,422 9,806,058  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .... 0      
7 Other salaries and wages 251,571,950 227,947,563 23,624,387 0
8 Pension plan contributions (include section 401(k) and section 403(b) employer contributions) .... 22,236,695 20,524,984 1,711,711  
9 Other employee benefits ....... 55,791,082 51,911,193 3,879,889  
10 Payroll taxes ........... 16,743,804 15,227,480 1,516,324  
11 Fees for services (non-employees):        
a Management ...... 0      
b Legal ......... 2,516,450 1,354,437 1,162,013  
c Accounting ........... 1,429,033 21,302 1,407,731  
d Lobbying ........... 0      
e Professional fundraising. See Part IV, line 17.. 0  
f Investment management fees ...... 103,010,425   103,010,425  
g Other .......... 47,253,642 35,554,820 11,698,822  
12 Advertising and promotion .... 0      
13 Office expenses ....... 9,182,298 4,628,077 4,554,221  
14 Information technology ...... 9,026,753 304,990 8,721,763  
15 Royalties .. 24,512   24,512  
16 Occupancy ........... 99,955,818 97,343,453 2,612,365  
17 Travel ............ 7,477,242 6,138,387 1,338,855  
18 Payments of travel or entertainment expenses for any federal, state, or local public officials ...... 0      
19 Conferences, conventions, and meetings .... 3,565,091 3,133,360 431,731  
20 Interest ........... 43,690,466 1,219,203 42,471,263  
21 Payments to affiliates ....... 0      
22 Depreciation, depletion, and amortization ..... 102,895,951 94,352,646 8,543,305  
23 Insurance .............. 304,234 15,558 288,676  
24 Other expenses. Itemize expenses not covered above. (Expenses grouped together and labeled miscellaneous may not exceed 5% of total expenses shown on line 25 below.)
a LAB & OTHER SCIENTIFIC SUPPLIE 134,998,859 133,443,471 1,555,388  
b MINOR EQUIPMENT & RENOVATIONS 22,328,121 46,373,477 -24,045,356  
c EQUIPMENT MAINTENANCE 12,941,511 11,958,546 982,965  
d PRINTING AND PUBLICATIONS 4,566,277 1,144,859 3,421,418  
e STATE SALES TAX & INCOME TAX -5,520,201 1,862,744 -7,382,945  
f All other expenses 1,649,826 1,276,503 373,323  
25 Total functional expenses. Add lines 1 through 24f 983,647,611 781,938,767 201,708,844 0
26 Joint costs. Check here MediumBullet if following
SOP 98-2 (ASC 958-720). Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation 		       
Form 990 (2010)
Form 990 (2010)
Page 11
Part X Balance Sheet
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash—non-interest-bearing ..........   1  
2 Savings and temporary cash investments ....... 731,879,619 2 705,785,736
3 Pledges and grants receivable, net .........   3  
4 Accounts receivable, net .........   4  
5 Receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
Schedule L ..........   5  
6 Receivables from other disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B). Complete Part II of
Schedule L ..........   6  
7 Notes and loans receivable, net .............   7  
8 Inventories for sale or use ..............   8  
9 Prepaid expenses and deferred charges ............ 4,680,933 9 3,292,970
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 1,706,455,953
b Less: accumulated depreciation. ..... 10b 851,181,144 867,034,339 10c 855,274,809
11 Investments—publicly traded securities .......... 6,252,874,258 11 8,077,485,060
12 Investments—other securities. See Part IV, line 11 ...... 8,765,485,348 12 8,272,827,729
13 Investments—program-related. See Part IV, line 11 ..   13  
14 Intangible assets .........   14  
15 Other assets. See Part IV, line 11 ........... 181,174,386 15 323,127,649
16 Total assets. Add lines 1 through 15 (must equal line 34)... 16,803,128,883 16 18,237,793,953
Liabilities 17 Accounts payable and accrued expenses . 334,557,730 17 340,996,712
18 Grants payable .......... 154,878,829 18 110,330,242
19 Deferred revenue ..........   19  
20 Tax-exempt bond liabilities .......... 683,000,000 20 683,000,000
21 Escrow or custodial account liability. Complete Part IV of Schedule D..   21  
22 Payables to current and former officers, directors, trustees, key
employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L..........   22  
23 Secured mortgages and notes payable to unrelated third parties ..   23  
24 Unsecured notes and loans payable to unrelated third parties .... 640,376,000 24 640,376,000
25 Other liabilities. Complete Part X of Schedule D..... 560,770,787 25 723,224,863
26 Total liabilities. Add lines 17 through 25..... 2,373,583,346 26 2,497,927,817
Net Assets or Fund Balance Organizations that follow SFAS 117, check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets ..... 14,429,545,537 27 15,739,866,136
28 Temporarily restricted net assets .....   28  
29 Permanently restricted net assets .....   29  
Organizations that do not follow SFAS 117, check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds .....   30  
31 Paid-in or capital surplus, or land, building or equipment fund .....   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ..... 14,429,545,537 33 15,739,866,136
34 Total liabilities and net assets/fund balances ..... 16,803,128,883 34 18,237,793,953
Form 990 (2010)
Form 990 (2010)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response to any question in this Part XI . . . . . . . . . .
1
Total revenue (must equal Part VIII, column (A), line 12) . . .
1
1,046,733,478
2
Total expenses (must equal Part IX, column (A), line 25) . . . . .
2
983,647,611
3
Revenue less expenses. Subtract line 2 from line 1 . . . .
3
63,085,867
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) . .
4
14,429,545,537
5
Other changes in net assets or fund balances (explain in Schedule O) . . . .
5
1,247,234,732
6
Net assets or fund balances at end of year. Combine lines 3, 4, and 5 (must equal Part X, line 33, column (B)) . . . . . .
6
15,739,866,136
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response to any question in this Part XII . . . . . . . . . .
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?..
2a
 
No
b
Were the organization’s financial statements audited by an independent accountant?........
2b
Yes
 
c
If “Yes,” to 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O............................
2c
Yes
 
d
If “Yes” to line 2a or 2b, check a box below to indicate whether the financial statements for the year were issued on a separate basis, consolidated basis, or both:
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133? ................
3a
 
No
b
If “Yes,” did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits. ..
3b
 
 
Form 990 (2010)
Additional Data


Software ID:  
Software Version:  
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ. right arrow See separate instructions.
OMB No. 1545-0047
2010
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
See Part IV,
  ,
Boston, MA  
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
f
g
(i) a person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the the supported organization? ................
11g(i)
 
 
(ii) a family member of a person described in (i) above? ......................
11g(ii)
 
 
(iii) a 35% controlled entity of a person described in (i) or (ii) above? ................
11g(iii)
 
 
h
(i)
Name of supported organization 		(ii)
EIN 		(iii)
Type of organization (described on lines 1- 9 above or IRC section (see instructions)) 		(iv)
Is the organization in col. (i) listed in your governing document? 		(v)
Did you notify the organization in col. (i) of your support? 		(vi)
Is the organization in col. (i) organized in the U.S.? 		(vii)
Amount of support?
Yes No Yes No Yes No
Total                  

For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2010
Schedule A (Form 990 or 990-EZ) 2010
Page 2
Part II
Support Schedule for Organizations Described in IRC 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year(or fiscal year beginning in) (a) 2006 (b) 2007 (c) 2008 (d) 2009 (e) 2010 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....            
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3..            
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..            
6 Public Support. Subtract line 5 from line 4.            
Section B. Total Support
Calendar year(or fiscal year beginning in) (a) 2006 (b) 2007 (c) 2008 (d) 2009 (e) 2010 (f) Total
7 Amounts from line 4..            
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. (Explain in Part IV.) Do not include gain or loss from the sale of capital assets..            
11 Total support (Add lines 7 through 10).            
12
12
 
13
Section C. Computation of Public Support Percentage
14
14
 
15
15
 
16a
b
17a
b
18
Schedule A (Form 990 or 990-EZ) 2010
Schedule A (Form 990 or 990-EZ) 2010
Page 3
Part III
Support Schedule for Organizations Described in IRC 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year(or fiscal year beginning in) (a) 2006 (b) 2007 (c) 2008 (d) 2009 (e) 2010 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513..            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public Support (Subtract line 7c from line 6.)            
Section B. Total Support
Calendar year (or fiscal year beginning in) (a) 2006 (b) 2007 (c) 2008 (d) 2009 (e) 2010 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)            
13 Total support (Add lines 9, 10c, 11 and 12.).            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2010
Schedule A (Form 990 or 990-EZ) 2010
Page 4
Part IV
Supplemental Information. Supplemental Information. Complete this part to provide the explanation required by Part II, line 10; Part II, line 17a or 17b; or Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Explanation
Pursuant to the Internal Revenue Service Ruling Letter dated November 5, 1998, the Institute is a medical research organization for the taxable year ended August 31, 2010. As a medical research organization, HHMI's expenditures on a cash basis of $795,087,404 exceed the MRO requirement (3.5% of HHMI endowment) of $529,715,317.
List of hospital affiliations for e-filing: Hospital,City,State,Zip Code/ B&W Hospital,Boston,MA,02115/ Children's Hosp,Boston,MA,02115/ Children's Hosp,Cincinnati,OH,45229/ Dana-Farber,Boston,MA,02115/ Fred Hutch,Seattle,WA,98109/ JHopkins Hosp,Baltimore,MD,21205/ Mass Gen Hosp,Boston,MA,02129/ MSKCC,New York,NY,10021/ Nat'l Jewish,Denver,CO,80206/ St. Jude,Memphis,TN,38105/ Duke-Duke Hosp,Durham,NC,27706/ Emory-Univ Hosp,Atlanta,GA,30322/ NYU-NYU Hosps,New York,NY,10016/ OHSU-OHSU Hosp,Portland,OR,97239/ Rockefeller-Hosp,New York,NY,10021/ Stanford-Hosp,Palo Alto,CA,94305/ UCLA-Med Ctr,Los Angeles,CA,90095/ UCSD-Med Ctr,San Diego,CA,92093/ UCSF-UCSF Hosps,San Francisco,CA,94143/ UIowa-UIowa Hosps,Iowa City,IA,52242/ UMass-Med Ctr,Worcester,MA,01605/ UMich-UMich Hosp,Ann Arbor,MI,48109/ UPenn-UPenn Hosp,Philadelphia,PA,19104/ UT-Austin-UT Hosp,Austin,TX,78712/ UTSW-UTSW Hosps,Dallas,TX,75390/ UUtah-UUtah Hosps,Salt Lake City,UT,84112/ UWash-Med Ctr,Seattle,WA,98195/ Vanderbilt-Hosp,Nashville,TN,37232/ ADARC-aff hosp,New York,NY,10016/ AECOM-affil hosps,New York,NY,10461/ Baylor-aff hosps,Houston,TX,77030/ BU-aff hosp,Boston,MA,02126/ Brandeis-aff hsps,Waltham,MA,02254/ CalTech-aff hosps,Pasadena,CA,91125/ Carnegie-aff hsps,Baltimore,MD,21210/ Case WR-aff hosps,Cleveland,OH,44106/ CSHL-affil hosps,Cold Spring Harbor,NY,11724/ CSU-affil hosp,Fort Collins,CO,80521/ Columbia-aff hsps,New York,NY,10027/ Cornell-aff hosps,New York,NY,14853/ Harvard-aff hosps,Cambridge,MA,02138/ TJL-affil hosps,Bar Harbor,ME,04609/ JHU-affil hosps,Baltimore,MD,21218/ MIT-affil hosps,Boston,MA,02139/ NWU-affil hosps,Evanston,IL,60208/ OMRF-aff hosp,Oklahoma City,OK,73104/ Princeton-aff hosps,Princeton,NJ,08544/ Purdue-aff hosp,W. Lafayette,IN,47907/ Rutgers-affil hosp,Piscataway,NJ,08854/ Salk-affil hosps,La Jolla,CA,92093/ Stowers-aff hosps,Kansas City,MO,64110/ SUNY-affil hosps,Stony Brook,NY,11794/ Texas A&M-aff hsp,College Station,TX,77843/ Tufts-aff hosps,Boston,MA,02111/ UAZ-affil hosp,Tucson,AZ,85721/ UCB-affil hosps,Berkeley,CA,94720/ UC-Davis-affil hsps,Davis,CA,95616/ UCSC-aff hosps,Santa Cruz,CA,95064/ UChi-affil hosp,Chicago,IL,60637/ UColo-aff hosp,Boulder,CO,80309/ UColo-aff hosp,Denver,CO,80217/ UFla-aff hosps,Gainesville,FL,32611/ UIllinois-aff hsp,Urbana,IL,61801/ UMD-affil hosp,Baltimore,MD,21201/ UMDNJ-aff hosp,Piscataway,NJ,08544/ UNC-affil hosps,Chapel Hill,NC,27599/ UOregon-aff hsp,Eugene,OR,97403/ UWisc-affil hosps,Madison,WI,53706/ WashU-aff hosp,St.Louis,MO,63130/ YaleU-affil hosp,New Haven,CT,06520/
 
 
Schedule A (Form 990 or 990-EZ) 2010

Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet Complete if the organization is described below.
SchCMd Bullet Attach to Form 990 or Form 990-EZ. SchCMd Bullet See separate instructions.
OMB No. 1545-0047
2010
Open to Public
Inspection
If the organization answered “Yes,” to Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered “Yes,” to Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)) Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered “Yes,” to Form 990, Part IV, Line 5 (Proxy Tax) or Form 990-EZ, Part V, line 35a (Proxy Tax), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization's direct and indirect political campaign activities on behalf of or in opposition to candidates for public office in Part IV.
2
Political expenditures ....................................SchCMd Bullet
$  
3
Volunteer hours ........................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 .........SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 ......SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ..............
4a
Was a correction made? .........................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c) except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt funtion activities ....................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b..SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ..........................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.










For Privacy Act and Paperwork Reduction Act Notice, see the instructions for Form 990.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2010

Schedule C (Form 990 or 990-EZ) 2010
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check
B Check
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
Organization's
Totals 		(b) Affiliated Group
Totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......    
b Total lobbying expenditures to influence a legislative body (direct lobbying) .......    
c Total lobbying expenditures (add lines 1a and 1b) ...................    
d Other exempt purpose expenditures ........................    
e Total exempt purpose expenditures (add lines 1c and 1d) ...............    
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		    
  If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:    
  Not over $500,00020% of the amount on line 1e.    
  Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.    
  Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.    
  Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.    
  Over $17,000,000$1,000,000.    
       
g Grassroots nontaxable amount (enter 25% of line 1f) .................    
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................    
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................    
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ......................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the instructions for lines 2a through 2f on page 4.)
Lobbying Expenditures During 4-Year Averaging Period
  Calendar year (or fiscal year
beginning in) 		(a) 2007 (b) 2008 (c) 2009 (d) 2010 (e) Total
             
2a Lobbying non-taxable amount          
             
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		         
             
c Total lobbying expenditures          
             
d Grassroots non-taxable amount          
             
e Grassroots ceiling amount
(150% of line 2d, column (e))		          
             
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2010


Schedule C (Form 990 or 990-EZ) 2010
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
(a)
Yes
No
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? .........................................
 
No
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ....
 
No
c
Media advertisements? ....................................
 
No
 
d
Mailings to members, legislators, or the public? .........................
 
No
 
e
Publications, or published or broadcast statements? .......................
 
No
 
f
Grants to other organizations for lobbying purposes? .......................
 
No
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? ........
 
No
 
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ......
 
No
 
i
Other activities? If "Yes," describe in Part IV ..........................
Yes
 
995
j
Total. lines 1c through 1i ...................................
995
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
No
b
If "Yes," enter the amount of any tax incurred under section 4912 .................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 .....
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? .......
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ................
2
 
 
3
Did the organization agree to carryover lobbying and political expenditures from the prior year? ..........
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) if BOTH Part III-A, lines 1 and 2 are answered “No” OR if Part III-A, line 3 is answered “Yes”.
1
Dues, assessments and similar amounts from members .....................
1
 
2
Section 162(e) non-deductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).
a
Current year .........................................
2a
 
b
Carryover from last year ....................................
2b
 
c
Total ...........................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) ..............
5
 
Part IV
Supplemental Information
Complete this part to provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; and Part ll-B, line 1i.
Also, complete this part for any additional information.
Identifier Return Reference Explanation
Other Activities Schedule C, Part II-B, line 1i (Other Activities) HHMI did not engage directly in any lobbying activities during the fiscal year. However, during the fiscal year, HHMI was a member of a number of non-profit organizations that engaged in lobbying activities on behalf of their memberships. HHMI is reporting as lobbying expenditures a portion of the membership dues that HHMI paid to these organizations.
Schedule C (Form 990 or 990EZ) 2010

Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11, or 12.
SchDMd Bullet Attach to Form 990. SchDMd Bullet See separate instructions.
OMB No. 1545-0047
2010
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .......    
2 Aggregate contributions to (during year) ...    
3 Aggregate grants from (during year) ...    
4 Aggregate value at end of year .......    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds may be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit. ...................................
Part II
Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a–2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ....................... 2a  
b Total acreage restricted by conservation easements .................. 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06 ........ 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the taxable year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................
6
Staff and volunteer hours devoted to monitoring, inspecting and enforcing conservation easements during the year SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section
170(h)(4)(B)(i) and 170(h)(4)(B)(ii)? ....................................
9
In Part XIV, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116, not to report in its revenue statement and balance sheet works of
art, historical treasures, or other similar assets held for public exhibition, education or research in furtherance of public service,
provide, in Part XIV, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116, to report in its revenue statement and balance sheet works of art,
historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service,
provide the following amounts relating to these items:
(i)
Revenues included in Form 990, Part VIII, line 1 ........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ..............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 relating to these items:
a
Revenues included in Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990
Cat. No. 52283D
Schedule D (Form 990) 2010

Schedule D (Form 990) 2010
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s accession and other records, check any of the following that are a significant use of its collection
items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIV.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b
If "Yes," explain the arrangement in Part XIV and complete the following table:
Amount
c Beginning balance ................................. 1c  
d Additions during the year .............................. 1d  
e Distributions during the year ............................. 1e  
f Ending balance ................................... 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21? .....................
b
If “Yes,” explain the arrangement in Part XIV.
Part V
Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.
(a)Current Year (b)Prior Year (c)Two Years Back (d)Three Years Back (e)Four Years Back
1a Beginning of year balance ....      
b Contributions ........      
c Investment earnings or losses ...      
d Grants or scholarships .....      
e Other expenditures for facilities
and programs ........ 		     
f Administrative expenses ....      
g End of year balance ......      
2
Provide the estimated percentage of the year end balance held as:
a
Board designated or quasi-endowment: SchDMd Bullet  
b
Permanent endowment: SchDMd Bullet  
c
Term endowment: SchDMd Bullet  
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations ........................
3a(i)
 
 
(ii) related organizations ........................
3a(ii)
 
 
b
If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIV the intended uses of the organization's endowment funds.
Part VI
Investments—Land, Buildings, and Equipment. See Form 990, Part X, line 10.
Description of investment (a) Cost or other basis (investment) (b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land ................. 807,737 37,588,921 38,396,658
b Buildings ................ 10,496,661 667,706,292 137,399,217 540,803,736
c Leasehold improvements ............ 2,878,464 424,060,143 359,281,309 67,657,298
d Equipment ................   511,550,966 354,005,342 157,545,624
e Other ................. 921,448 50,445,321 495,276 50,871,493
Total. Add lines 1a-1e. (Column (d) should equal Form 990, Part X, column (B), line 10(c).)........SchDMdBullet 855,274,809
Schedule D (Form 990) 2010

Schedule D (Form 990) 2010
Page 3
Part VII
Investments—Other Securities. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c) Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
(3)Other
(A) PRIVATE EQUITY & REAL ESTATE 		7,974,371,011 F

(B) NATURAL RESOURCES 		294,773,354 F

(C) ALTERNATIVE INVESTMENTS 		3,683,364 F






Total. (Column (b) should equal Form 990, Part X, col.(B) line 12.)Small Bullet 8,272,827,729
Part VIII
Investments—Program Related. See Form 990, Part X, line 13.
(a) Description of investment type (b) Book value (c) Method of valuation:
Cost or end-of-year market value








Total. (Column (b) should equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. See Form 990, Part X, line 15.
(a) Description (b) Book value








Total. (Column (b) should equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities. See Form 990, Part X, line 25.
1.(a) Description of Liability (b) Amount
Federal Income Taxes 0
SHORT POSITIONS 303,062,717
REPURCHASE OBLIGATIONS & INT P 101,663,466
INVESTMENT PURCHASES PENDING S 53,140,169
MANAGEMENT FEES PAYABLE 15,856,745
OPTIONS PAYABLE 873,331
DEFERRED COMPENSATION LIABILIT 16,456,519
CURRENCY EXCHANGE CONTRACTS PA 7,531,271
SWAP UNREALIZED LOSS 224,496,448
PAYABLE REALIZED GAINS ON FUTU 22,875
DEFERRED INCOME 121,322
Total. (Column (b) should equal Form 990, Part X, col.(B) line 25.)Small Bullet 723,224,863
2. Fin 48 (ASC 740) Footnote. In Part XIV, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC740).
Schedule D (Form 990) 2010

Schedule D (Form 990) 2010
Page 4
Part XI Reconciliation of Change in Net Assets from Form 990 to Financial Statements
1 Total revenue (Form 990, Part VIII, column (A), line 12) .................... 1 1,046,733,478
2 Total expenses (Form 990, Part IX, column (A), line 25) ..................... 2 983,647,611
3 Excess or (deficit) for the year. Subtract line 2 from line 1 ............. 3 63,085,867
4 Net unrealized gains (losses) on investments .......................... 4 1,247,234,732
5 Donated services and use of facilities ............................. 5  
6 Investment expenses ................................... 6  
7 Prior period adjustments .................................. 7  
8 Other (Describe in Part XIV) ................................. 8  
9 Total adjustments (net). Add lines 4 - 8 ............................. 9 1,247,234,732
10 Excess or (deficit) for the year per financial statements. Combine lines 3 and 9 ......... 10 1,310,320,599
Part XII Reconciliation of Revenue per Audited Financial Statements With Revenue per Return
1 Total revenue, gains, and other support per audited financial statements ....... 1 2,180,442,471
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains on investments .......... 2a 1,247,234,732
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIV): ............ 2d  
e Add lines 2a through 2d ..................... 2e 1,247,234,732
3 Subtract line 2e from line 1..................... 3 933,207,739
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a 113,525,739
b Other (Describe in Part XIV): ........... 4b  
c Add lines 4a and 4b....................... 4c 113,525,739
5 Total Revenue. Add lines 3 and 4c. (This should equal Form 990, Part I, line 12.) ...... 5 1,046,733,478
Part XIII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return
1 Total expenses and losses per audited financial statements ............. 1 870,121,872
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities .......... 2a  
b Prior year adjustments .............. 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIV): ............ 2d  
e Add lines 2a through 2d...................... 2e  
3 Subtract line 2e from line 1..................... 3 870,121,872
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a 113,525,739
b Other (Describe in Part XIV): ............ 4b  
c Add lines 4a and 4b....................... 4c 113,525,739
5 Total expenses. Add lines 3 and 4c. (This should equal Form 990, Part I, line 18.) ...... 5 983,647,611
Part XIV
Supplemental Information
Complete this part to provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X; Part XI, line 8; Part XII, lines 2d and 4b; and Part XIII, lines 2d and 4b. Also complete this part to provide any additional information.
Identifier Return Reference Explanation
Schedule D (Form 990) 2010

Additional Data


Software ID:  
Software Version:  




SCHEDULE F
(Form 990)

Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,
Part IV, line 14b, 15, or 16.
Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.
OMB No. 1545-0047
2010
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
General Information on Activities Outside the United States. Complete if the organization answered
“Yes” to Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of the grants or
assistance, the grantees' eligibility for the grants or assistance, and the selection criteria used to award
the grants or assistance? ...................................
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of grant funds outside the
United States.
3
Activites per Region. (Use Part V if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees or agents in region or independent contractors (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total
expenditures for region/investments
in region
Sub-Saharan Africa     Grantmaking Grants for TB/HIV 690,000
East Asia and the Pacific     Investments   172,207,000
Europe (Including Iceland and Greenland)     Investments   681,319,000
North America     Investments   148,822,000
Central America     Investments   168,711,000
South Asia     Investments   86,466,000
Sub-Saharan Africa   1 Program Services MEDICAL RESEARCH 11,396,000
           
           
           
           
           
           
           
           
           
           
3a Sub-total .....   1 1,269,611,000
b Total from continuation sheets to Part I ...      
c Totals (add lines 3a and 3b)   1 1,269,611,000
For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2010
Schedule F (Form 990) 2010
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" to Form 990,
Part IV, line 15, for any recipient who received more than $5,000. Check this box if no one recipient received more than $5,000 ........ MediumBullet
Use Part V if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount of
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2
Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .....MediumBullet
 
3
Enter total number of other organizations or entities ........................MediumBullet
 
Schedule F (Form 990) 2010
Schedule F (Form 990) 2010Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Use Part V if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
HIV/TB Research Sub-Saharan Africa 9 690,000 WT      
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2010
Schedule F (Form 990) 2010
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926 (see instructions for Form 926).................
2 Did the organization have an interest in a foreign trust during the tax year? If " Yes," the organization may be required to file Form 3520 and/or Form 3520-A. (see instructions for Forms 3520 and 3520-A)..........
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with respect to Certain Foreign Corporations. (see instructions for Form 5471)..............................
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If "Yes," the organization may be required to file Form 8621, Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see instructions for Form 8621)
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with respect to Certain Foreign Partnerships. (see instructions for Form 8865)....................................
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see instructions for Form 5713)................................................
Schedule F (Form 990) 2010
Schedule F (Form 990) 2010
Page 5
Part V
Supplemental Information
Complete this part to provide the information (see instructions) required in Part I, line 2, and any additional information.
Identifier ReturnReference Explanation
Monitoring of foreign grant funds Schedule F, Part 1, Line 2 During its 2011 fiscal year, HHMI continued to support International Research Scholars selected through one or more competitions open to all eligible applicants. Eligibility requirements included, but were not limited to, a full-time appointment at a nonprofit scientific research organization in a country other than the United States, and a research focus on basic biological processes or disease mechanisms. Qualified applicants were evaluated by a panel of scientific experts with final selections made by HHMI leadership. The disbursement of grant funds to support the work of International Research Scholars is made in accordance with all applicable U.S. laws. Funds are paid to an institutional account. In order to monitor the activities and productivity of the grants, each scientist is required to submit an annual progress report concerning his or her research and each grantee institution is required to submit annual financial reports. These reports, which are submitted online, are subject to review and analysis by HHMI staff. Site visits and audits are conducted if warranted and grantees are also brought together for periodic meetings to present research progress reports. Expenditures made by HHMI in support of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) are handled in a somewhat different manner. K-RITH was established in 2009 as an international research center in Durban, South Africa, in collaboration between the Institute and the University of KwaZulu-Natal (UKZN), with the mission of conducting outstanding basic science research on tuberculosis (TB) and HIV, translating the scientific findings into new tools to control TB and HIV, and expanding the educational opportunities in the region. In 2010, internationally-renowned tuberculosis researcher Dr. William Bishai was brought on as K-RITH's first director. K-RITH has recently been incorporated as an independent non-profit entity under South African law. More information about K-RITH is available from its website, which is at http://www.k-rith.org/. In 2009, during the start-up phase of its collaboration with UKZN, HHMI commissioned an assessment of the internal financial controls at UKZN by the accounting firm of Deloitte & Touche. After being satisfied by the systems in place at UZKN, HHMI has been making quarterly payments to UKZN in support of scientific research, the design and construction of a new laboratory building, and the retrofit of existing laboratory space. These payments are made on the basis of invoices from UKZN that are carefully reviewed and reconciled by HHMI. In addition, HHMI staff make regular visits to UKZN and received detailed financial reports from UKZN delivered on a quarterly or more frequent basis.
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
Schedule F (Form 990) 2010
Additional Data


Software ID:  
Software Version:  



Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," to Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990
OMB No. 1545-0047
2010
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number
59-0735717
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ....................................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Governments and Organizations in the United States. Complete if the organization answered "Yes" to
Form 990, Part IV, line 21 for any recipient that received more than $5,000. Check this box if no one recipient received more than $5,000. Use
Part IV and Schedule I-1 (Form 990) if additional space is needed ......................... lBullet
(a) Name and address of organization
or government		 (b) EIN (c) IRC Code section
if applicable		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
non-cash assistance		 (h) Purpose of grant
or assistance
(1) Travel Exps paid-behalf-grantees-AMR Corp4333 Amon Carter Blvd
Fort Worth,TX76155 		75-1825172   7,611       EXROP Program - Housing
(2) Travel Exps paid-behalf-grantees-United Airlines77 W Wacker Drive
Chicago,IL60601 		36-2675207   7,027       EXROP Program - Housing
(3) Travel Exps paid-behalf-grantees-US Airways111 West Rio Salado Pkwy
Tempe,AZ85281 		54-1194634   6,282       EXROP Program - Housing
(4) Harvard UniversityHarvard University
Cambridge,MA02138 		04-2103580 501 (c) (3) 42,914       EXROP Program - Housing
(5) Housing paid-behalf-grantees-International House500 Riverside Drive
New York,NY10027 		13-1624048   25,942       EXROP Program - Housing
(6) Johns Hopkins UnivJohns Hopkins University
Baltimore,MD21218 		52-0595110 501 (c) (3) 10,436       EXROP Program - Housing
(7) Stanford UnivStanford University
Palo Alto,CA94305 		94-1156365 501 (c) (3) 14,673       EXROP Program - Housing
(8) UC - San DiegoUC - San Diego
La Jolla,CA92093 		95-6006144 501 (c) (3) 7,392       EXROP Program - Housing
(9) Univ of ColoradoUniv of Colorado
Boulder,CO80309 		84-6000555 501 (c) (3) 7,262       EXROP Program - Housing
(10) Univ of MassachusettsUniv of Massachusetts
Worchester,MA01605 		04-3167352 501 (c) (3) 6,090       EXROP Program - Housing
(11) Univ of WashingtonUniv of Washington
Seattle,WA98195 		91-6001537 501 (c) (3) 17,477       EXROP Program - Housing
(12) Amer Soc - Cell Biology8120 Woodmont Avenue
Bethesda,MD20814 		39-6054285 501 (c) (3) 400,000       Summer Institute
(13) United Way-Natl Capital Area8391 Old Courthouse Road
Vienna,VA22182 		53-0234290 501 (c) (3) 25,000       Local Area
(14) Baylor College of MedBaylor College of Medicine
Houston,TX77030 		74-1613878 501 (c) (3) 8,080       EXROP Program - Housing
(15) Memorial Sloan KetteringMemorial Sloan Kettering
New York,NY10021 		13-1624182 501 (c) (3) 5,457       EXROP Program - Housing
(16) Yale UniversityYale University
New Haven,CT06520 		06-0646973 501 (c) (3) 11,335       EXROP Program - Housing
(17) WETA3939 Campbell Avenue
Arlington,VA22206 		53-0242992 501 (c) (3) 125,000       Greater PBS Newshour
(18) Audubon Naturalist Soc8940 Jones Mill Road
Chevy Chase,MD20815 		53-0233715 501 (c) (3) 50,000       Precollege Local Inititative
(19) Chesapeake Bay Foundation162 Prince George Street
Annapolis,MD21401 		52-6065757 501 (c) (3) 150,000       Precollege Local Inititative
(20) Montgomery Cty PS Educ Found850 Hungerford Drive
Rockville,MD20850 		52-1804509 501 (c) (3) 545,000       Precollege Local Inititative
(21) PG County Public Schools14201 School Lane
Upper Marlboro,MD20772 		52-6000992 MD county 40,000       Precollege Local Inititative
(22) Loudoun Cty Public Schools21000 Education Court
Leesburg,VA20176 		54-6001395 VA county 1,000,000       PreCollege Science - Other
(23) MITMassachusetts Institute of Technolo
Cambridge,MA02139 		04-2103594 501 (c) (3) 12,680       EXROP Program - Housing
(24) Univ of MinnesotaUniv of Minnesota
Minneapolis,MN55415 		41-6007513 501 (c) (3) 40,000       Summer Institute
(25) Univ of OregonUniv of Oregon
Eugene,OR97403 		48-1278531 501 (c) (3) 6,642       EXROP Program - Housing
(26) Evergreen State CollegeEvergreen State College
Olypmia,WA98195 		91-0826533 501 (c) (3) 40,000       Summer Institute
(27) Indiana Univ of PennsylvaniaIndiana Univ of Pennsylvania
Indiana,PA15705 		25-1753112 501 (c) (3) 179,000       Summer Institute
(28) Univ of ColoradoUniv of Colorado
Boulder,CO80309 		84-6000555 501 (c) (3) 40,000       Summer Institute
(29) Yale UniversityYale University
New Haven,CT06520 		06-0646973 501 (c) (3) 2,000,000       Summer Institute
(30) Travel Exps paid-behalf-grantees-Extended Stay11525 N Community House Rd
Charlotte,NC28277 		20-1627433   7,601       EXROP Program - Housing
(31) Harvard Stem Cell Institute1350 Massachusetts Avenue
Cambridge,MA02138 		04-2103580 501 (c) (3) 27,744       EXROP Program - Housing
(32) Travel Exps paid-behalf-grantees-Longwood Inn123 Longwood Avenue
Brookline,MA02446 		04-2932331   15,020       EXROP Program - Housing
(33) Travel Exps paid-behalf-grantees-Mermaid Inn Motel727 El Camino Real
Menlo Park,CA94025 		94-1654909   6,185       EXROP Program - Housing
(34) New York UnivNew York Univ
New York,NY10003 		13-5562308 501 (c) (3) 7,400       EXROP Program - Housing
(35) New York UniversityNew York University
New York,NY10003 		13-5562308 501 (c) (3) 30,000       NOVA
(36) Long Island UnivLong Island Univ
Greenvale,NY11548 		11-1633516 501 (c) (3) 50,000       Conference support - Understanding Interventions that Broaden Participation in Research Careers
(37) Cold Spring Harbor LabCold Spring Harbor Lab
Cold Spring Harbor,NY11724 		11-2013303 501 (c) (3) 2,425,000       Courses
(38) Jackson LabJackson Lab
Bar Harbor,ME04609 		01-0211513 501 (c) (3) 2,250,000       Courses
(39) Marine Biological LabMarine Biological Lab
Woods Hole,MA02543 		04-2104690 501 (c) (3) 2,650,000       Courses
2
Enter total number of section 501(c)(3) and government organizations ......................... Bullet Image
32
3
Enter total number of other organizations ................................ . Bullet Image
7
For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2010

Schedule I (Form 990) 2010
Page 2
Part III
Grants and Other Assistance to Individuals in the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 22.
Use Schedule I-1 (Form 990) if additional space is needed.
(a)Type of grant or assistance (b)Number of
recipients		 (c)Amount of
cash grant		 (d)Amount of
non-cash assistance		 (e)Method of valuation (book,
FMV, appraisal, other)		 (f)Description of non-cash assistance
(1) EXROP Program 81 364,500      
(2) Gilliam Fellowships 9 2,092,500      
(3) Investigator Educational Activity 1 200,000      
(4) Science Education Alliance 1 55,000      
(5) International Predoctoral Fellowwships 48 6,192,000      





Part IV
Supplemental Information. Complete this part to provide the information required in Part I, line 2, and any other additional information.
Identifier Return Reference Explanation
Monitoring of Grants funds Schedule I, Part 1, Line 2 HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the U.S. through periodic national competitions for which select institutions are eligible to apply. Each program sets out specific criteria and objectives; proposals are evaluated by a panel of experts with the final selection made by HHMI leadership. The Institute also awards fellowships to international predoctoral students; to medical students seeking to conduct basic laboratory research; to doctoral students (the Gilliam Fellows), and to early career physician scientists. These grants are also awarded on a competitive basis. A small number of grants are awarded based on direct application to HHMI for specific initiatives directly related to science education. The disbursement of funds occurs principally through institutions: biomedical research institutions, universities, and colleges. HHMI grantees are required to file annual progress reports that detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds. These are subject to careful review and analysis by HHMI staff with more detailed review by the Institute auditors as warranted. The Institute continues to assess reporting requirements to ensure the quality and timeliness of both financial and programmatic reports. In addition to site visits made by HHMI staff, program directors meet on a regular basis to discuss their activities and share information about best educational practices.
Exrop Housing Schedule I, Part II, Line 1 As part of the EXROP program, housing was provided to program participants at locations that included the International House, Extended Stay Deluxe Hotel, the Longwood Inn and the Mermaid Inn Motel. In addition, transportation was provided for program participants, including air travel on American Airlines, United Airlines and U.S. Airways.
Schedule I (Form 990) 2010


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Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" to Form 990,
Part IV, question 23.
SchJMediumBullet Attach to Form 990. SchJMediumBullet See separate instructions.
OMB No. 1545-0047
2010
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement orprovision of all the expenses described above? If "No," complete Part III to explain....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
officers, directors, trustees, and the CEO/Executive Director, regarding the items checked in line 1a? ....
2
Yes
 
3
Indicate which, if any, of the following the organization uses to establish the compensation of the
organization's CEO/Executive Director. Check all that apply.
4
During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ...............
4a
 
No
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? ........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? ........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.
5
For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization? .........................
5b
 
No
If "Yes," to line 5a or 5b, describe in Part III.
6
For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ...........................
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," to line 6a or 6b, describe in Part III.
7
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regs. section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
Yes
 
9
If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
Yes
 
For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990
Cat. No. 50053T
Schedule J (Form 990) 2010

Schedule J (Form 990) 2010
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use Schedule J-1 if additional space needed.
For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.

Note. The sum of columns (B)(i)-(iii) must equal the applicable column (D) or column (E) amounts on Form 990, Part VII, line 1a.
(A) Name (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation
reported in prior
Form 990 or
Form 990-EZ
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
(1) Robert Tjian PhD (i)
(ii)		 1,067,706
0 		0
  		15,000
  		24,500
  		35,864
  		1,143,070
0 		0
 
(2) Craig A Alexander Esq (i)
(ii)		 539,103
  		10,000
  		16,500
  		24,500
  		28,633
  		618,736
  		0
 
(3) Sean B Carroll PhD (i)
(ii)		 294,290
  		0
  		21,181
  		24,500
  		22,267
  		362,238
  		0
 
(4) Jack E Dixon PhD (i)
(ii)		 674,505
  		0
  		58,278
  		24,500
  		37,138
  		794,421
  		0
 
(5) Mohamoud Jibrell (i)
(ii)		 220,636
  		5,000
  		0
  		21,471
  		22,393
  		269,500
  		0
 
(6) Avice A Meehan (i)
(ii)		 394,808
  		0
  		16,500
  		24,500
  		16,613
  		452,421
  		0
 
(7) Edward J Palmerino (i)
(ii)		 341,210
  		0
  		16,500
  		24,500
  		23,564
  		405,774
  		0
 
(8) Gerald M Rubin PhD (i)
(ii)		 651,646
  		0
  		26,500
  		24,500
  		99,071
  		801,717
  		0
 
(9) Landis Zimmerman (i)
(ii)		 668,209
  		396,202
  		16,500
  		24,500
  		29,056
  		1,134,467
  		0
 
(10) Robert C Mullins (i)
(ii)		 224,143
  		0
  		15,500
  		21,867
  		30,593
  		292,103
  		0
 
(11) Heidi E Henning Esq (i)
(ii)		 382,766
  		0
  		16,500
  		24,500
  		29,690
  		453,456
  		0
 
(12) Cheryl A Moore (i)
(ii)		 556,407
  		0
  		82,413
  		24,500
  		21,089
  		684,409
  		0
 
(13) Susan S Plotnick (i)
(ii)		 217,872
  		0
  		0
  		20,548
  		23,460
  		261,880
  		0
 
(14) Richard A Pender (i)
(ii)		 448,747
  		340,627
  		16,500
  		24,500
  		28,413
  		858,787
  		0
 
(15) Robert J Kolyer Jr (i)
(ii)		 397,338
  		201,539
  		16,500
  		24,500
  		21,827
  		661,704
  		0
 
(16) Stephen M Kitsoulis (i)
(ii)		 342,341
  		231,874
  		0
  		24,500
  		24,057
  		622,772
  		0
 
(17) Mark A Barnard (i)
(ii)		 342,367
  		127,223
  		16,500
  		24,500
  		34,145
  		544,735
  		0
 
(18) Eric R Kandel MD (i)
(ii)		 524,352
  		0
  		16,000
  		24,500
  		45,336
  		610,188
  		0
 
(19) Anil Madhok (i)
(ii)		 315,044
  		187,227
  		16,500
  		24,500
  		22,388
  		565,659
  		0
 
(20) Matthew R Lee (i)
(ii)		 313,722
  		172,092
  		16,500
  		24,500
  		21,591
  		548,405
  		0
 
(21) Gunter Blobel MD PhD (i)
(ii)		 418,677
  		0
  		15,214
  		24,500
  		64,361
  		522,752
  		0
 
(22) Richard Axel MD (i)
(ii)		 426,030
  		0
  		2,000
  		24,500
  		19,878
  		472,408
  		0
 
(23) Thomas R Cech PhD (i)
(ii)		 536,956
  		400,000
  		16,500
  		24,500
  		22,248
  		1,000,204
  		0
 
(24) Joseph D Collins (i)
(ii)		 163,320
  		49,262
  		8,250
  		20,936
  		10,687
  		252,455
  		0
 
(25) David A Clayton PhD (i)
(ii)		 109,086
  		0
  		0
  		10,083
  		27,524
  		146,693
  		0
 
(26) Peter J Bruns PhD (i)
(ii)		 446,828
  		0
  		11,000
  		24,500
  		22,319
  		504,647
  		0
 
Schedule J (Form 990) 2010

Schedule J (Form 990) 2010
Page 3
Part III
Supplemental Information
Complete this part to provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 4c, 5a, 5b, 6a, 6b, 7, and 8. Also complete this part for any additional information.
Identifier Return Reference Explanation
Part 1 Line 1a   First-class travel: Under HHMI policies, HHMI reimburses its Trustees, President, Vice Presidents, and certain advisory group members for the reasonable cost of airfare at one class above coach for domestic or international flights of three hours or more. If a particular aircraft does not have a business class section, one class above coach may be first class. In this case HHMI would reimburse the traveling Trustee or officer for the reasonable cost of first-class travel if the flight is three hours or more. As an alternative, HHMI may reimburse for the cost of coach airfare plus the cost of an upgrade to travel at one level above coach for a flight of three hours or more. Housing for personal use: HHMI's President currently resides in an HHMI-owned apartment on the headquarters campus, for which he pays HHMI at a fair market rental rate. Because HHMI's President is also required to spend time at HHMI's Janelia campus, where he runs a research laboratory as well as attending meetings and participating in conferences, HHMI makes a one-bedroom apartment available to him at that location. HHMI's Vice President and Director, Janelia Farm Research Campus is required as a condition of employment to reside on the Janelia campus in housing built for that purpose. HHMI's Vice President and Chief Scientific Officer receives a mortgage subsidy from HHMI under a Housing Assistance Program for certain individuals who relocate to take positions with HHMI. The Executive Vice President and Chief Operating Officer also receives housing assistance from HHMI under this program. In each case, the subsidy is treated as additional taxable compensation. Tax gross-up payments: Under HHMI's moving expense reimbursement policy, if an employee is relocating at HHMI's request, HHMI will ordinarily provide a tax gross-up for the reimbursable moving expenses that must be treated as taxable to the employee. HHMI continued to follow this standard practice during the 2011 fiscal year.
Part I Line 7   HHMI has an incentive compensation plan for its senior investment staff under which a portion of their compensation is determined based on performance of HHMI's portfolio against market benchmarks. HHMI also makes one-time payments to some of its other employees in recognition of exceptional performance.
Part I Line 8   When recruiting individuals for high-level positions, HHMI typically enters into initial contracts. HHMI has entered into initial contracts with its President and a number of Vice Presidents. HHMI's standard practice is to have independent compensation consultants regularly review and confirm the reasonableness of compensation of HHMI's officers and key employees, regardless of whether the initial contract exception applies.
Schedule J (Form 990) 2010

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Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Schedule O (Form 990).
SchKMediumBullet Attach to Form 990. SchKMediumBullet See separate instructions.
OMB No. 1545-0047
2010
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number
59-0735717
Part I
Bond Issues
(a) Issuer Name (b) Issuer EIN (c) CUSIP # (d) Date Issued (e) Issue Price (f) Description of Purpose (g) Defeased (h) On
Behalf of
Issuer 		(i) Pool
financing
Yes No Yes No Yes No
A LOUDOUN COUNTY IDA
  		52-1310230 545910AL5 02-27-2003 500,000,000 finance construction of Janeli   X   X   X
B MEDCO
  		52-1376562 574205FY1 02-15-2008 83,500,000 finance construction of HQ exp   X   X   X
C LOUDOUN COUNTY IDA
  		52-1310230 545910AP6 10-02-2009 23,000,000 finance contruction of Janelia   X   X   X
D MEDCO
  		52-1376562 574205FZ8 05-15-2008 76,500,000 refunding of issue to finance   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired. . . . . 0 0 0 0
2 Amount of bonds defeased . . . . 0 0 0 0
3 Total proceeds of issue . . . . 500,000,000 83,500,000 23,000,000 76,500,000
4 Gross proceeds in reserve funds . .        
5 Capitalized interest from proceeds. 878,276   878,276  
6 Proceeds in refunding escrow. . . . .        
7 Issuance costs from proceeds . . .        
8 Credit enhancement from proceeds.        
9 Working capital expenditures from proceeds . .        
10 Capital expenditures from proceeds . . 500,000,000 83,500,000 21,620,962 76,500,000
11 Other spent proceeds . .        
12 Other unspent proceeds. . . 0 0 500,762 0
13 Year of substantial completion . . . 2006 2010 2011 1993
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue?   X   X X X    
15 Were the bonds issued as part of an advance refunding issue?   X   X   X   X
16 Has the final allocation of proceeds been made? . . X   X     X X  
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . X   X   X   X  
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . .   X   X   X    
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . .   X   X   X    
For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2010
Schedule K (Form 990) 2010
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use?   X   X   X    
b Are there any research agreements that may result in private business use of bond-financed property? . . X     X   X    
c Does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts or research agreements relating to the financed property? . X   X   X      
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . . . . . . . . . . . . . SchKMediumBullet 0 % 0 % 0 %  
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . SchKMediumBullet 0 % 0 % 0 %  
6 Total of lines 4 and 5 . . .. . . . . . 0 % 0 % 0 %  
7 Has the organization adopted management practices and procedures to ensure the post-issuance compliance of its tax-exempt bond liabilities? X   X   X      
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has a Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate, been filed with respect to the bond issue? . . . X     X   X X  
2 Is the bond issue a variable rate issue? X   X   X   X  
3a Has the organization or the governmental issuer entered into a hedge with respect to the bond issue? X   X   X   X  
b Name of provider . BARCLAYS
  		JP MORGAN
  		JP MORGAN CHASE
  		 
 
c Term of hedge . . 10. 30. 30. 30.
d Was the hedge superintegrated? .   X   X   X   X
e Was a hedge terminated? .   X   X   X   X
4a Were gross proceeds invested in a GIC? .   X   X   X   X
b Name of provider .  
  		 
  		 
  		 
 
c Term of GIC . .        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? .                
5 Were any gross proceeds invested beyond an available temporary period? .   X   X   X   X
6 Did the bond issue qualify for an exception to rebate? . . . X   X   X   X  
Schedule K (Form 990) 2010

Schedule K (Form 990) 2010
Page 3
Part V
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule K (see instructions).
Identifier Return Reference Explanation
Supplemental Information on Tax Exempt Bonds Parts I & IV Part I and Part IV, Line 3 The bond issued on February 27, 2003 and described in A also includes CUSIPS 545910AM3, 545910AG6, 545910AH4,545910AJ0 and 545910AK7. $375 million of the $500 million of swaps pertaining to this bond were integrated. The other swaps were Bank of America (30 years), Goldman (30 years), JP Morgan (35 years) and JP Morgan Chase (30 years). Part IV, Line 6, A, C and D Yes, in part.
Schedule K (Form 990) 2010

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Schedule L
(Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Transactions with Interested Persons
MediumBullet Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V lines 38a or 40b.
MediumBullet Attach to Form 990 or Form 990-EZ. MediumBulletSee separate instructions.
OMB No. 1545-0047
2010
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Excess Benefit Transactions (section 501(c)(3) and section 501 (c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1(a) Name of disqualified person (b) Description of transaction (c) Corrected?
Yes No





2
Enter the amount of tax imposed on the organization managers or disqualified persons during the year under section 4958. ......................... Bullet Image$
 
3
Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image$
 

Part II
Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 26, or Form 990-EZ, Part V, line 38a.
(a) Name of interested person and purpose (b) Loan to or from the organization? (c)Original principal amount (d)Balance due (e) In default? (f) Approved by board or committee? (g)Written agreement?
To From Yes No Yes No Yes No
Total ...............Small Bullet $  
Part III
Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.
(a) Name of interested person (b)Relationship between interested person and the organization (c)Amount of grant or type of assistance
For Privacy Act and Paperwork Reduction Act Notice, see the
Instructions for Form 990 or 990-EZ.
Cat. No. 50056A
Schedule L (Form 990 or 990-EZ) 2010
Schedule L (Form 990 or 990-EZ) 2010
Page 2
Part IV
Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of transaction (d) Description of transaction (e) Sharing of organization's revenues?
Yes No
(1) American Express Company Shared Trustee/Director 552,000 see Supplemental Information   No
Part V
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule L (see instructions).
Identifier Return Reference Explanation
Reportable Business Transactions Part IV, Line d A trustee of HHMI is also a director of American Express Company. HHMI paid American Express Company for travel and related services provided to HHMI in the ordinary course of business.
Schedule L (Form 990 or 990-EZ) 2010

Additional Data


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SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
OMB No. 1545-0047
2010
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Identifier Return Reference Explanation
Authority over Financial Account in a Foreign Country Core Form, Part V, Line 4b RUSSIA ARGENTINA AUSTRALIA AUSTRIA BELGIUM BERMUDA BRAZIL CANADA CHILE CHINA COLOMBIA CZECH REPUBLIC DENMARK EGYPT ESTONIA FINLAND FRANCE GERMANY GREECE HONG KONG HUNGARY INDIA INDONESIA IRELAND ISRAEL ITALY JAPAN JORDAN LUXEMBOURG MALAYSIA MAURITIUS MEXICO MOROCCO NETHERLANDS NEW ZEALAND NORWAY PERU PHILIPPINES POLAND PORTUGAL SINGAPORE SLOVENIA SOUTH AFRICA SOUTH KOREA SPAIN SRI LANKA SWEDEN SWITZERLAND TAIWAN THAILAND TURKEY UKRAINE UNITED KINGDOM URUGUAY VENEZUELA ZIMBABWE HHMI has signature authority over investment accounts in foreign countries through their custodian, Bank of New York Mellon. HHMI also has direct signature authority in Mauritius and Singapore.
Relationships Between Trustees/officers Core Form, Part VI, Line 2 HHMI Trustee Dr. Joseph Goldstein is also a Trustee of the Rockefeller University, which was the employer of HHMI Trustee Dr. Paul Nurse during part of HHMI's 2011 fiscal year. Dr. Nurse is no longer an employee of Rockefeller University. Both HHMI Trustee Anne Tatlock and former HHMI President Dr. Thomas Cech served as directors of Merck & Co., Inc., during HHMI's 2011 fiscal year.
Description of 990 Review Process Core Form, Part VI, Line 11A The Howard Hughes Medical Institute's Form 990 is initially prepared by its Tax Compliance Department, in coordination with other HHMI departments as needed. The draft return is reviewed by senior management of HHMI's Finance Department and by attorneys in HHMI's Office of the General Counsel. Following these reviews and the resolution of any questions that have been raised, the draft return is reviewed by HHMI's outside tax preparer. Finally, a copy of the return is provided to the members of HHMI's Board of Trustees so that they have an opportunity to review and comment on the return before it is filed.
Conflict of Interest Policy Core Form, Part VI, Line 12a-12c In addition to HHMI's code of conduct, which addresses conflicts of interest and applies to all HHMI employees, officers, Trustees, and advisors, HHMI has specific conflict of interest policies for different categories of personnel. Under the HHMI policies that apply to Trustees, officers, and key employees, these individuals must disclose annually interests that could give rise to conflicts of interest, and must certify annually their compliance with the conflict of interest policy that applies to them. Annual disclosures and certifications are reviewed by HHMI's Office of the General Counsel, and by other HHMI managers as needed. The conflict of interest policy covering HHMI's Trustees also requires each Trustee to disclose to the other Trustees any actual or apparent conflict of interest with respect to a proposed HHMI transaction. If the other Trustees decide that there is only the appearance of a conflict of interest, and that it could not reasonably be considered to affect the independent, unbiased judgment of the disclosing Trustee with respect to the transaction at issue, no further action is required to address the apparent conflict. In all other cases, including all actual conflicts of interest, the disclosing Trustee is not permitted to participate in the deliberation or decision regarding the transaction under consideration, and must leave the room during the deliberation and vote. The conflict of interest policy covering HHMI's officers and key employees requires each covered individual to obtain supervisory approval up to the level of HHMI's President before entering into an affiliation with or acquiring an interest of 1% or more in any entity that is or may become a recipient of HHMI funds. HHMI's President, in consultation with HHMI's General Counsel, may permit the affiliation or interest if it would not interfere with the covered individual's performance of his or her HHMI responsibilities, would not create the appearance of a conflict of interest, and would be consistent with sound business judgment. HHMI's President may set conditions on approval, for example that there be no remuneration to the covered individual. Proposed affiliations and interests of 1% or more of HHMI's President are subject to the approval of the Chairman of the Trustees.
Process for determining compensation Core Form, Part VI, Lines 15a-b The compensation for HHMI's President, other officers, and key employees is set using the following procedures. Every other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent compensation consultants to conduct a study of comparable market data. The study includes data for HHMI's President, other officers, and key employees. The independent compensation consultants also provide an opinion regarding the reasonableness of the compensation arrangements for the positions included in the study. The study includes comparable market data for all components of compensation for each person covered by the study, including base salary, incentive compensation (if any), and benefits. The Committee relies on the market data and opinion provided by the compensation consultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers and key employees. The decision is made by independent Trustees. Any Trustee who has a conflict of interest with respect to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, and leave the meeting room during the debate and voting on it. In the alternate years when a study is not done, the Audit and Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit increases for HHMI employees, including senior management, is reasonable compared with generally prevailing compensation increases in the market over the past year. The Committee relies on this advice in recommending compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in making compensation decisions. Recusal procedures are the same in as in the years when a study is done. In each year, minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for approval at the next meeting. Approved minutes are kept in HHMI's records. All minutes include the date of the meeting, identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees with a conflict of interest. The comparability studies and opinions relied on at the meeting are referenced in the minutes, and copies of these materials are also kept in HHMI's records. HHMI's Board of Trustees followed this process in August 2011 in determining compensation for the following positions: President; Vice Presidents; and Managing Directors - Investments.
Governing documents etc available to the public Core Form, Part VI, Line 19 HHMI's practice has been to make a copy of its charter and by-laws available on request. HHMI's code of conduct, which addresses conflicts of interest, is available to the public on the HHMI web site. A downloadable copy of HHMI's most recent audited financial statements is also available to the public on the web site. In addition, HHMI publishes an annual report that provides a summary of each year's activity, expenditures, and financial performance; this publication is widely distributed in print and is posted on the HHMI web site.
Whistleblower policy Core Form, Part VI, Line 13 HHMI has had a written whistleblower policy in place since 2003. While this policy has been discussed with HHMI's Trustees in the past, it was not formally adopted by the Trustees or a committee of the Trustees before the end of the tax year covered by this Form 990. The policy is expected to be presented to the Trustees or a committee of the Trustees for approval in the tax year covered by HHMI's next Form 990.
Document Retention & Destruction Policy Core Form, Part VI, Line 14 HHMI has had written document retention and destruction policies in place for many years. These policies were not adopted by HHMI's Trustees or a committee of the Trustees before the end of the tax year covered by this Form 990. The policies are expected to presented to the Trustees or a committee of the Trustees for approval in the tax year covered by HHMI's next Form 990.
Other Changes of Net Assets Core Form, Part XI, Line 5 Unrealized gains on investments
Attachment 2 (continued-1) Part III, Program Service, line 4a - Medical Research (H) Highlights from HHMI Research Laboratories (Fiscal Year 2011) (1) The Tangled Biology of Aggression David Anderson, California Institute of Technology You can be a lover or a fighter-but not at the same time, and studies in mice are hinting at why. Examining the activity of neurons in a tiny region buried deep within the animals' brains, researchers found that the neural circuits controlling aggression and mating are closely intertwined. Specifically, postdoctoral researcher Dayu Lin in Anderson's lab recorded the activity of individual neurons in the ventromedial nucleus of the hypothalamus. He found that one subset of neurons fired during aggressive behavior, and a partially overlapping but distinct set fired during mating. Many of the aggression neurons were inhibited during mating. However, when the researchers overcame this inhibition in male mice by artificially stimulating the neurons associated with aggression, the mice attacked females rather than mating with them. The close relationship between the two groups of neurons may normally help suppress aggressive behavior during mating. (2) Antibiotic Resistance: A Team Effort James Collins, Boston University With teamwork, entire groups of bacteria can resist certain antibiotics, even when only a few individuals have their own tools for survival. Researchers discovered this bacterial altruism when they grew E. coli in the presence of the antibiotic norfloxacin and removed small samples to test for acquired resistance to the drug. They discovered that under the onslaught of norfloxacin, a few of the bacteria acquired resistance and manufactured a metabolite called indole, which seeped into the communal broth and triggered protective mechanisms in their nonresistant neighbors. The researchers say that drugs designed to interfere with the indole pathway might block the microbes' ability to share resistance. (3) Shutting Off Anxiety Karl Deisseroth, Stanford University Scientists are beginning to shine a light on the neural circuits that underlie anxiety, the most common psychiatric disease. With the flick of a light-activated genetic switch that lets them manipulate specific neurons in the brain, scientists have reduced symptoms of anxiety in laboratory mice. The experiments demonstrated that a cluster of neurons in the amygdala-an almond-shaped structure in the brain-helps control apprehension in the absence of any immediate threat. By manipulating the activity of two distinct neural circuits, which they found to have opposing effects on anxiety, the researchers could elicit strikingly rapid effects on anxiety-related behaviors in mice. (4) Preventing Aortic Aneurysm in Marfan Patients Harry Dietz, The Johns Hopkins University School of Medicine Losartan, an FDA-approved drug used to treat high blood pressure, is being evaluated for its ability to prevent enlargement of the aorta in patients with Marfan syndrome. The clinical trials follow promising experiments in which losartan dramatically slowed aneurysm progression in a mouse model of Marfan syndrome. While the trials are under way, researchers continue to investigate the cellular signals that contribute to aneurysm progression in Marfan syndrome. Their experiments have generated a new understanding of those signals-and how losartan alters them-that is expected to help guide both current treatment decisions and efforts to develop therapies that might offer benefits that losartan does not. (5) Spotting Cancer Stem Cells in the Crowd Elaine Fuchs, The Rockefeller University Stem cells can differentiate into multiple cell types and divide in perpetuity, two qualities that make them potential tools for regenerative medicine. Cancer stem cells, on the other hand, use the same characteristics to wreak havoc. Two signaling pathways that scientists found are critical to regulating the growth of squamous cancer stem cells-which can seed tumors in the skin, head, neck, lungs, esophagus, and other tissues-will now help researchers discriminate between those menacing cells and normal stem cells in the skin. Interfering with these cancer-specific pathways could lead to drugs that destroy cancer stem cells more effectively while sparing normal stem cells. (6) Antibody Recognizes Many Strains of Flu Stephen Harrison, Harvard Medical School Strains of influenza virus change so much that a new vaccine must be developed every year to prime patients' immune systems to target the current threat. After studying a patient with an unusually well-equipped immune system, researchers think it may be possible to ready the body to fight off a wide variety of influenza strains. From that individual's army of immune cells, scientists identified a single antibody that recognized and blocked 30 of 36 strains of influenza that have arisen since 1988. The antibody binds so tightly to a surface pocket on the virus that recognizes human cells that its binding appears not to be strongly affected if the surrounding area mutates. The researchers hope to use this information to design an influenza vaccine that provides broad protection against many strains of influenza. (7) Gene Editing Reduces Hemophilia Symptoms in Mice Katherine High, The Children's Hospital of Philadelphia The blood clotting disorder hemophilia B is caused by defects in a clotting factor called Factor IX. Researchers have corrected the disorder in mice by repairing the gene with a scissor-like molecular tool that snips out the defective region of the gene. The tool, called a zinc-finger nuclease, specifically targets the defective segment of DNA and is administered along with a flawless segment of the Factor IX gene. Once the defective segment is excised, the cell's DNA repair proteins take over, copying the correct version of the gene. After treatment with Factor IX zinc-finger nucleases, mice with severe hemophilia B gained enough clotting factors to downgrade their disease from severe to mild. (8) Missing DNA Key to Human Evolution David Kingsley, Stanford University School of Medicine Among the features that set humans apart from other animals are 510 segments of regulatory DNA that are present in other species but surprisingly missing from the human genome. Researchers showed that two of the missing sequences help explain why humans lack the sensory whiskers and spiny penises possessed by many other mammals, but have evolved much larger brains. The loss of specific regulatory sequences likely contributed to the evolution of these and other human traits. The findings mirror evidence from other species indicating that changes to regulatory regions of DNA, rather than to genes themselves, underlie many of the features that organisms acquire during evolution. (9) Spliceosome Caught on Camera Melissa Moore, University of Massachusetts Medical School Spliceosomes prepare the genetic code to be translated into proteins by chopping out long strings of genetic material and stitching the remaining segments back together. The spliceosome has five major parts that dynamically interact with one another and with the RNA that they process. In human cells, these components must find one another and assemble into a spliceosome millions of times a day to keep protein production moving along. By labeling each component with a different fluorescent tag and tracking the individual molecules with a microscope equipped with four different-colored lasers, researchers have now captured the massive spliceosome assembly on camera. They witnessed a continuous shifting of parts, which suggests that the assembly process can be shut down or reversed once it has begun.
Attachment 2 (continued-2) Part III, Program Service, line 4a - Medical Research (10) Searching for a Marker for PTSD Kerry Ressler, Emory University School of Medicine A single terrifying event can cause deep and lasting damage in some people, while leaving others psychologically unharmed. Now, researchers have discovered that a protein called PACAP (pituitary adenylate cyclase activating polypeptide) is present in higher levels in the blood of women with post-traumatic stress disorder than in those who experienced traumatic events but had not been diagnosed with the disorder. Experiments with mice suggest that PACAP activity in regions of the brain that mediate fear and stress increases in the presence of estrogen. The researchers say the results could lead to a blood test for susceptibility to PTSD in women. PACAP levels were not associated with PTSD symptoms in men. (11) Lighting Up the Fruit Fly Brain Julie Simpson, Janelia Farm Research Campus With a genetically encoded color palette, Janelia Farm scientists have transformed the neurons of a fruit fly's brain into disorderly rainbows of color. The new tool, called dBrainbow, gives different types of neurons distinct colors so scientists can trace their paths through the brain. dBrainbow expands the reach of the Brainbow technique developed by other researchers in 2007 for color coding the brains of mice. The new version will aid the studies of neuroscientists who investigate the brain of the fruit fly, a powerful system for learning about the neural basis of behavior. (12) The Origins of Two Epidemics Matthew Waldor, Brigham and Women's Hospital With the latest DNA sequencing technology, researchers have been hot on the trail of the pathogenic microbes responsible for two major outbreaks of infectious disease. In December 2010, they traced the origins of the strain of cholera responsible for the outbreak that began in Haiti in October 2010, killing more than 6,200 people. By comparing the genome sequence of bacteria isolated from patients affected during the post-earthquake outbreak with the sequences of cholera strains isolated in other parts of the world, the scientists concluded that the Haiti strain originated in South Asia. In May 2011, the scientists turned their attention to an unusual strain of E. coli that was sickening people in Germany-and would eventually cause symptoms in more than 4,000 people in 16 countries, including many cases of life-threatening hemolytic-uremic syndrome. They used a similar analysis to determine that the dangerous strain likely emerged when a less pathogenic E. coli picked up a critical set of virulence genes. (13) What It Takes to Control HIV Naturally Bruce Walker, Massachusetts General Hospital A small fraction of people who are infected with HIV can control it without drugs; they are now helping scientists learn about potential ways to fight the virus. The first genome-wide association study of these individuals, called elite controllers, has identified a few amino acids that seem to predict a person's ability to keep the virus in check. Those amino acids help determine how the immune system recognizes HIV-infected cells. The findings indicate what an effective natural immune response is and how it is induced-information that could help generate more effective vaccine-induced immune responses to prevent or treat HIV. (14) New Targets for Melanoma Therapies Leonard Zon, Children's Hospital Boston Researchers are using a tiny, translucent fish to identify cellular signals that can drive the development and progression of melanoma. After analyzing more than 2,100 zebrafish tumors, researchers identified a single enzyme, SETDB1, which seemed to accelerate melanoma. They followed these experiments with an analysis of human melanoma cell lines and found that the SETDB1 gene was overactive in 70 percent of those cells. Zebrafish also led researchers to a second molecule, DHODH, which is involved in formation of the stem cells that give rise to melanoma. This protein, which helps convert DNA to RNA, can be shut down with an arthritis drug, suggesting that the drug might be combined with existing therapies to treat melanoma in humans. (I) Honors and Awards Received by HHMI Scientists (1)Friedman Wins Lasker Award HHMI investigator Jeffrey M. Friedman of The Rockefeller University and Douglas Coleman of The Jackson Laboratory, won the 2010 Lasker Award for Basic Medical Research, the nation's most prestigious award in basic and clinical research. (2) Fuchs Wins Albany Medical Center Prize Elaine Fuchs, an HHMI investigator at Rockefeller University, was one of three scientists awarded the 2011 Albany Medical Center Prize in Medicine and Biomedical Research. (3) Wiley Prize Goes to Lily Y. Jan and Yuh Nung Jan HHMI investigators Lily Y. Jan and Yuh Nung Jan, a husband and wife team who share a lab at the University of California, San Francisco, won the 2011 Wiley Prize in Biomedical Sciences. (4) Lindquist and Benkovic Presented With National Medals of Science At a ceremony at the White House, President Obama presented a 2010 National Medal of Science to HHMI investigator Susan Lindquist of the Massachusetts Institute of Technology. Stephen J. Benkovic of Pennsylvania State University, who is a member of HHMI's Scientific Review Board, also received a medal. The National Medal is the nation's highest scientific honor given by the government. (5) Shaw Prize Given to Medzhitov The Shaw Prize Foundation awarded Ruslan M. Medzhitov, an HHMI investigator at Yale University, the Shaw Prize in Life Science and Medicine. (6) HHMI Scientists Join National Academy of Sciences Six HHMI investigators, one international research scholar, and one member of HHMI's Scientific Review Board were elected to the National Academy of Sciences. The investigators are David P. Bartel, Massachusetts Institute of Technology; Harry C. Dietz, The Johns Hopkins University School of Medicine; Steven E. Jacobsen, University of California, Los Angeles; David M. Kingsley, Stanford University School of Medicine; J. Andrew McCammon, University of California, San Diego; and Michel C. Nussenzweig, The Rockefeller University. The international research scholar is Alberto R. Kornblihtt, University of Buenos Aires. The HHMI Scientific Review Board member is Luis F. Parada, University of Texas Southwestern Medical Center at Dallas. (7) Six HHMI Researchers Elected to Institute of Medicine Elected this year to the National Academy of Sciences' Institute of Medicine were HHMI investigators Peter Cresswell, Yale University School of Medicine; Robert B. Darnell, The Rockefeller University; Jennifer A. Doudna, University of California, Berkeley; and Kevan M. Shokat, University of California, San Francisco. Also elected was HHMI early career scientist Karl Deisseroth, Stanford University. Sydney Brenner, a senior fellow at HHMI's Janelia Farm Research Campus, was named a foreign associate of the institute. (8) Chory and Steitz Elected to Royal Society HHMI investigators Joanne Chory, the Salk Institute, and Thomas A. Steitz, Yale University, were elected foreign members of the Fellowship of the Royal Society, the world's oldest scientific academy. (9) AAAS Names HHMI Scientists Fellows Nine HHMI investigators, two HHMI international research scholars, and the chair of the K-RITH Scientific Advisory Board were chosen as new fellows of the American Association for the Advancement of Science. The investigators are Frederick W. Alt, Children's Hospital Boston; Jason G. Cyster, University of California, San Francisco; Robert B. Darnell, The Rockefeller University; Gideon Dreyfuss, University of Pennsylvania School of Medicine; Yishi Jin, University of California, San Diego; Jeannie T. Lee, Massachusetts General Hospital; Stuart H. Orkin, Children's Hospital Boston; Li-Huei Tsai, Massachusetts Institute of Technology; and John D. York, Duke University. The international research scholars are Charles M. Boone, University of Toronto, and Freda D. Miller, Hospital for Sick Children, Toronto. The K-RITH board member is Barry R. Bloom, Harvard School of Public Health.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2010

Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" to Form 990, Part IV, line 33, 34, 35, 36, or 37.
MediumBulletAttach to Form 990. MediumBullet See separate instructions.

OMB No. 1545-0047
2010
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Identification of Disregarded Entities (Complete if the organization answered "Yes" on Form 990, Part IV, line 33.)
(a)
Name, address, and EIN of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income
(e)
End-of-year assets


 		(f)
Direct controlling
entity







(1) HHMI Cayman I Company
Walker Walkers House Mary Street
George Town,Grand Cayman  
CJ
Investment CJ 167,940 2,848,061  
(2) HHMI II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 29,069,727 286,960,723  
(3) HHMI IV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 27,611 63,785  
(4) HHMI V LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 13,811,007 248,174,225  
(5) HHMI XII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 5,520 29,148  
(6) HHMI XVI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 41,928,500 490,942,984  
(7) Sprugos Mauritius I Ltd
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment MP 2,964,083 85,628,804  
(8) Sprugos Investments II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 9,338,006 279,226,088  
(9) Sprugos Investments V LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 22,398,995 158,468,254  
(10) Sprugos Investments VII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 18,017,947 272,363,997  
(11) Sprugos Investments VIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(12) Sprugos Investments X LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 15,786,237 101,213,953  
(13) Sprugos Investments XI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 277,898 125,643,126  
(14) Sprugos Investments XII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 7,961,017 50,164,694  
(15) Sprugos Investments XIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 9,624,664 244,908,559  
(16) Private Equity Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(17) Private Equity Holding-Ahead LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 647,413 5,470,356  
(18) Private Equity Holding-Alexa LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -810,763 766,031  
(19) Private Equity Holding-CS Capital LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 6,946,395 18,667,632  
(20) Private Equity Holding-Eurocastle LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 597,264 4,005,842  
(21) Private Equity Holding-Favrille LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(22) Private Equity Holding-KAP LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   1  
(23) Private Equity Holding-Royce LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   3,458  
(24) Private Equity Holding-Storeretro LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   1  
(25) Private Equity Holding-Xenoport LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(26) Fortress Pinnacle Investment Fund I LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(27) Janelia Farm Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment VA      
(28) Selden Island Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment VA      
(29) HHMI I LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(30) HHMI III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(31) HHMI VI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(32) HHMI VII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(33) HHMI VIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(34) HHMI IX LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(35) HHMI X LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(36) HHMI XI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(37) HHMI XIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(38) HHMI XIV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(39) HHMI XV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(40) Sprugos Investments LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(41) Sprugos Investments III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(42) Sprugos Investment IV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(43) Sprugos Investment VI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(44) Sprugos Investments IX LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(45) Sprugos-French LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(46) Private Equity Holding II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(47) Private Equity Holding III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(48) Relative Value Strategies LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE      
(49) PSG LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -381,357 31,795,480  
(50) HHMI-SA LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Research DE   221,967  
(51) K-RITH Real Estate Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Real Estate DE   182,733  
Part II
Identification of Related Tax-Exempt Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.)
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section
(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled organization
Yes No












For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2010
Schedule R (Form 990) 2010
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.)
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V—UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No
(1) Leland Hughes Investment Fund LLC

4000 Jones Bridge Road
Chevy Chase,MD20815
06-1746533 		Investment DE  
Excluded -2,637,032 13,086   No -18,668   No 54.000 %
(2) Advent Japan Private Equity Fund LP

75 State Street
Boston,MA02109
26-1362490 		Investment MA  
Excluded       No     No 82.000 %
(3) Alchemy Plan (Aviator) LP

Trafalgar Court Les Banques
St. Peter Port   GY1 3QL
GK
98-0186264 		Investment GK  
Excluded 1,705,309 1,099,338   No     No 99.000 %
(4) JP Morgan Global Emerging Markets Fund L

245 Park Avenue
New York,NY10167
04-3395941 		Investment NY  
Excluded 43,414,800 215,829,361   No     No 82.000 %
(5) GEM HLT CO-INV Fund LP

900 North Michigan Avenue Suite 14
Chicago,IL60611
26-3195475 		Investment IL  
Excluded 1,521,761 20,643,104   No     No 62.000 %
(6) HHMI Investment LP

300 Crescent Court Suite 1111
Dallas,TX75201
20-3752378 		Investment DE  
Excluded 12,314,010 172,732,592   No     No 96.000 %
(7) Harrington Partners LP

601 Carlson Pkwy Suite 200
Minnetonka,MN55305
20-1953018 		Investment MN  
Excluded 31,529,068 118,684,408   No 5,476,185   No 52.000 %
(8) Luminus Credit Opportunities PIE I LP

1700 Broadway 38th Floor
New York,NY10019
26-1963557 		Investment NY  
Excluded 11,734,007 157,292,302   No     No 99.000 %
(9) Oz Global Credit Overseas Fund I LP

PO Box 309 Ugland House
Grand Cayman    
CJ
98-0581241 		Investment CJ  
Excluded 11,810,208 83,983,419   No     No 97.000 %
Part IV
Identification of Related Organizations Taxable as a Corporation or Trust (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.)
(a)
Name, address, and EIN of related organization



 		(b)
Primary activity



 		(c)
Legal domicile
(state or
foreign
country)
 		(d)
Direct controlling
entity


 		(e)
Type of entity
(C corp, S corp,
or trust)

 		(f)
Share of total income



 		(g)
Share of
end-of-year
assets

 		(h)
Percentage
ownership
(1) HHMI Real Estate Inc
4000 Jones Bridge Road
Chevy Chase,MD20815
20-3967202 		Investment DE NA
  		C Corp 487,176 130,518,056 100.000 %
(2) Pleasant Valley Investments LP
80 Raffles Place 35-41UOB Plaza 1
Singapore   048624
SN
98-0586696 		Investment CJ NA
  		For. LP/US Corp   42,930,003 51.000 %










Schedule R (Form 990) 2010
Schedule R (Form 990) 2010
Page 3
Part V
Transactions With Related Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35, 35A, or 36.)
Note. Complete line 1 if any entity is listed in Parts II, III or IV.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest (ii) annuities (iii) royalties (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .
1a
 
No
b Gift, grant, or capital contribution to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1b
 
No
c Gift, grant, or capital contribution from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1c
 
No
d Loans or loan guarantees to or for other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1d
 
No
e Loans or loan guarantees by other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1e
 
No
f Sale of assets to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1f
 
No
g Purchase of assets from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1g
 
No
h Exchange of assets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1h
 
No
i Lease of facilities, equipment, or other assets to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1i
 
No
j Lease of facilities, equipment, or other assets from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .
1j
 
No
k Performance of services or membership or fundraising solicitations for other organization(s) . . . . . . . . . . . . . . . . . . . . . .
1k
 
No
l Performance of services or membership or fundraising solicitations by other organization(s) . . . . . . . . . . . . . . . . . . . . . .
1l
 
No
m Sharing of facilities, equipment, mailing lists, or other assets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1m
 
No
n Sharing of paid employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1n
 
No
o Reimbursement paid to other organization for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1o
 
No
p Reimbursement paid by other organization for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1p
 
No
q Other transfer of cash or property to other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1q
Yes
 
r Other transfer of cash or property from other organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1r
Yes
 
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of other organization 		(b)
Transaction
type(a-r) 		(c)
Amount involved 		(d)
Method of determining amount involved
(1) HHMI Real Estate Inc

 q 16,032,747  
(2) Pleasant Valley Investments LP

 q 6,556,056  
(3) Advent Japan Private Equity Fund LP

 q 2,263,339  
(4) HHMI Investment LP

 q 2,392,936  
(5) Advent Japan Private Equity Fund LP

 r 360,345  
(6) Alchemy Plan (Aviator)LP

 r 9,685,376  
(7) JP Morgan Global Emerging Markets Fund LLC

 r 25,000,000  
(8) GEM HLT Co-inv Fund LP

 r 1,800,000  
(9) Harrington Partners LP

 r 31,202,445  
(10) Luminus Credit Opportunities PIE I LP

 r 13,088,272  
(11) OZ Global Credit Overseas Fund I LP

 r 79,386,792  
Schedule R (Form 990) 2010
Schedule R (Form 990) 2010
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 37.)
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Are all
partners
section
501(c)(3)
organizations? 		(e)
Share of
end-of-year
assets 		(f)
Disproprtionate allocations? 		(g)
Code V—UBI
amount in box
20 of Schedule K-1
(Form 1065) 		(h)
General or
managing
partner?
Yes No Yes No Yes No






























Schedule R (Form 990) 2010
Schedule R (Form 990) 2010
Page 5
Part VII
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule R (see instructions).
Identifier Return Reference Explanation
Additional Data


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