Form990
Click to see attachment
Department of the Treasury
Internal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except black lung benefit trust or private foundation)

MediumBullet The organization may have to use a copy of this return to satisfy state reporting requirements.
OMB No. 1545-0047
2011
Open to Public Inspection
A For the calendar year, or tax year beginning 12-01-2011 and ending 11-30-2012
BCheck if applicable:
CName of organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Doing Business As
 
 
Number and street (or P.O. box if mail is not delivered to street address)
445 N 5TH STREET SUITE 600
 
Room/suite
City or town, state or country, and ZIP + 4
PHOENIX, AZ85004
D Employer identification number

75-3065445
E Telephone number

G Gross receipts $ 48,492,051
F Name and address of principal officer:
JEFFREY TRENT PHD
SAME AS C ABOVE
PHOENIX,AZ85004
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.TGEN.ORG
H(a)
Is this a group return for
affiliates?
H(b)
Are all affiliates included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:
 
L Year of formation: 2002
M State of legal domicile: AZ
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: SEE SCHEDULE O
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a)..... 3 15
4 Number of independent voting members of the governing body (Part VI, line 1b) .... 4 13
5 Total number of individuals employed in calendar year 2011 (Part V, line 2a) ... 5 402
6 Total number of volunteers (estimate if necessary) .... 6 60
7a Total unrelated business revenue from Part VIII, column (C), line 12 .. 7a 0
b Net unrelated business taxable income from Form 990-T, line 34 .. 7b 0
Revenues; Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 39,499,881 27,781,232
9 Program service revenue (Part VIII, line 2g) ......... 20,855,027 19,840,214
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 328,555 20,014
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 138,641 850,591
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)................... 60,822,104 48,492,051
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 0 0
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 28,036,987 26,595,987
16a Professional fundraising fees (Part IX, column (A), line 11e)..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet0    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24f).... 45,136,527 31,036,585
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 73,173,514 57,632,572
19 Revenue less expenses. Subtract line 18 from line 12....... -12,351,410 -9,140,521
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 50,603,221 42,514,714
21 Total liabilities (Part X, line 26)............. 17,805,103 18,198,184
22 Net assets or fund balances. Subtract line 21 from line 20..... 32,798,118 24,316,530
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title.
Paid preparer use only
Print/type preparer's name
 
Preparer's signature
Date
PTIN
Firm's name Right pointing arrowhead image

Firm's EIN Right pointing arrowhead image
Firm's address Right pointing arrowhead image



Phone no.
May the IRS discuss this return with the preparer shown above? See instructions .........bullet
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y
Form 990 (2011)
Form 990 (2011)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response to any question in this Part III .........
1
Briefly describe the organization’s mission: SEE SCHEDULE O
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ....................
If “Yes,” describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program services? ..........................
If “Yes,” describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations and section 4947(a)(1) trusts are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 5,908,534 including grants of $ 0 ) (Revenue $ 344,531 )
CLINICAL TRIALS - SEE SCHEDULE O.
4b (Code:   ) (Expenses $ 5,343,208 including grants of $ 0 ) (Revenue $ 436,538 )
CANCER AND CELL BIOLOGY DIVISION - SEE SCHEDULE O.
4c (Code:   ) (Expenses $ 8,508,617 including grants of $ 0 ) (Revenue $ 1,502,155 )
GENOTYPING TECHNOLOGY CENTER - SEE SCHEDULE O.
4d Other program services (Describe in Schedule O.)
(Expenses $ 14,779,438 including grants of $ 0 ) (Revenue $ 18,407,581 )
4e Total program service expensesMediumBullet$ 34,539,797
Form 990 (2011)
Form 990 (2011)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If “Yes,” complete Schedule AClick to see attachment.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors? Click to see attachment........
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If “Yes,” complete Schedule C, Part I..........
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities? If “Yes,” complete Schedule C,
Part II.........................
4
 
No
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If “Yes,” complete Schedule C, Part III........................
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If “Yes,” complete Schedule D, Part IClick to see attachment....................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas or historic structures? If “Yes,” complete Schedule D, Part IIClick to see attachment...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If “Yes,” complete Schedule D, Part III Click to see attachment....................
8
 
No
9
Did the organization report an amount in Part X, line 21; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If “Yes,”
complete Schedule D, Part IVClick to see attachment...................
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments? If “Yes,” complete Schedule D, Part VClick to see attachment
10
Yes
 
11
If the organization’s answer to any of the following questions is ‘Yes,’ then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable:
a
Did the organization report an amount for land, buildings, and equipment in Part X, line10? If “Yes,” complete Schedule D, Part VI.Click to see attachment
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VII.Click to see attachment
11b
 
No
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIII.Click to see attachment
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part IX.Click to see attachment
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If “Yes,” complete Schedule D, Part X.Click to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If “Yes,” complete Schedule D, Part X.Click to see attachment
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year?
If “Yes,” complete Schedule D, Parts XI, XII, and XIII Click to see attachment
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If “Yes,” and if the organization answered ‘No’ to line 12a, then completing Schedule D, Parts XI, XII, and XIII is optional Click to see attachment
12b
 
No
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If “Yes,” complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States?....
14a
 
No
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States or aggregate foreign investments valued at $100,000 or more? If “Yes,” complete Schedule F, Part I......... Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or assistance to any organization or entity located outside the U.S.? If “Yes,” complete Schedule F, Part II.. Click to see attachment
15
 
No
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or assistance to individuals located outside the U.S.? If “Yes,” complete Schedule F, Part III.. Click to see attachment
16
 
No
17
Did the organization report a total of more than $15,000, of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If “Yes,” complete Schedule G, Part I
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If “Yes,” complete Schedule G, Part II..........
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If “Yes,” complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospitals? If “Yes,” complete Schedule H.....
20a
 
No
b
If “Yes” to line 20a, did the organization attach a copy of its audited financial statement to this return? Note. All Form 990 filers that operated one or more hospitals must attach audited financial statements.
20b
 
 
Form 990 (2011)
Form 990 (2011)
Page 4
Part IV
Checklist of Required Schedules (continued)
21
Did the organization report more than $5,000 of grants and other assistance to any government or organization in the United States on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II..
21
 
No
22
Did the organization report more than $5,000 of grants and other assistance to individuals in the United States on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III.....
22
 
No
23
Did the organization answer “Yes” to Part VII, Section A, questions 3, 4, or 5, about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If “Yes,” complete Schedule J................ Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer questions 24b–24d and complete Schedule K. If “No,” go to line 25................
24a
 
No
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
 
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds?......................
24c
 
 
d
Did the organization act as an “on behalf of” issuer for bonds outstanding at any time during the year?...
24d
 
 
25a
Section 501(c)(3) and 501(c)(4) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If “Yes,” complete Schedule L, Part I...... Click to see attachment
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If “Yes,” complete Schedule L, Part I................ Click to see attachment
25b
 
No
26
Was a loan to or by a current or former officer, director, trustee, key employee, highly compensated employee, or disqualified person outstanding as of the end of the organization’s tax year? If “Yes,” complete Schedule L,
Part II......................... Click to see attachment
26
 
No
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or family member of any of these persons? If “Yes,” complete Schedule L, Part III......... Click to see attachment
27
 
No
28
Was the organization a party to a business transaction with one of the following parties? (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If “Yes,” complete Schedule L, Part IV ......................... Click to see attachment
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If “Yes,”
complete Schedule L, Part IV................... Click to see attachment
28b
 
No
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or owner? If “Yes,” complete Schedule L, Part IV.. Click to see attachment
28c
Yes
 
29
Did the organization receive more than $25,000 in non-cash contributions? If “Yes,” complete Schedule MClick to see attachment
29
Yes
 
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If “Yes,” complete Schedule M............ Click to see attachment
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If “Yes,” complete Schedule N,
Part I...........................
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If “Yes,” complete Schedule N, Part II.......................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If “Yes,” complete Schedule R, Part I........ Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If “Yes,” complete Schedule R, Parts II, III, IV, and V, line 1..................... Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If “Yes,” complete Schedule R, Part V, line 2... Click to see attachment
35b
Yes
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If “Yes,” complete Schedule R, Part V, line 2........... Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If “Yes,” complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11 and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2011)
Form 990 (2011)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response to any question in this Part V .........
Yes
No
1a
Enter the number reported in Box 3 of Form 1096. Enter -0- if not applicable. .......
1a
47
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable.
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and Tax Statements filed for the calendar year ending with or within the year covered by this return .....................
2a
402
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?

Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file. (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?.............................
3a
 
No
b
If “Yes,” has it filed a Form 990-T for this year? If “No,” provide an explanation in Schedule O.....
3b
 
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account or securities account)?.......................
4a
Yes
 
b
If "Yes," enter the name of the foreign country: MediumBulletLU
See instructions for filing requirements for Form TD F 90-22.1, Report of Foreign Bank and Financial Accounts.
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year?..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If “Yes” to line 5a or 5b, did the organization file Form 8886-T? ........
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible?..........
6a
 
No
b
If “Yes,” did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible?........................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor?....................
7a
 
No
b
If “Yes,” did the organization notify the donor of the value of the goods or services provided?.....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282?...........................
7c
 
No
d
If “Yes,” indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?..........................
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract?..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?...................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C?...............
7h
 
 
8
Sponsoring organizations maintaining donor advised funds and section 509(a)(3) supporting organizations. Did the supporting organization, or a donor advised fund maintained by a sponsoring organization, have excess business holdings at any time during the year?................
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the organization make any taxable distributions under section 4966?.........
9a
 
 
b
Did the organization make a distribution to a donor, donor advisor, or related person?......
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them) ........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If “Yes,” enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. All 501(c)(29) organizations must list in Schedule O each state in which they are licensed to issue qualified health plans, the amount of reserves required by each state, and the amount of reserves the organization allocated to each state.
13a
 
 
b
Enter the aggregate amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans.
13b
 
c
Enter the aggregate amount of reserves on hand.
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
 
b
If "Yes," has it filed a Form 720 to report these payments? If “No,” provide an explanation in Schedule O..
14b
 
 
Form 990 (2011)
Form 990 (2011)
Page 6
Part VI
Governance, Management, and Disclosure For each “Yes” response to lines 2 through 7b below, and for a “No” response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response to any question in this Part VI .........
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year
If the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
1a
15
b
Enter the number of voting members included in line 1a, above, who are independent .................
1b
13
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
Yes
 
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed?
4
Yes
 
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
Yes
 
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? .................
7a
Yes
 
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ............
7b
Yes
 
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .........................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ..........
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If “Yes,” provide the names and addresses in Schedule O .....
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal
Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If “Yes,” did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes? ....
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form?
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review the Form 990. .....
12a
Did the organization have a written conflict of interest policy? If “No,” go to line 13.......
12a
Yes
 
b
Were officers, directors or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If “Yes,” describe in Schedule O how this was done ....................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes," to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If “Yes,” did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
AZ
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how), the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, physical address, and telephone number of the person who possesses the books and records of the organization: MediumBullet
CHARLES K COLESON
445 N 5TH STREET SUITE 600
PHOENIX,AZ85004
(602) 343-8599
Form 990 (2011)
Form 990 (2011)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response to any question in this Part VII .........
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation, and current key employees. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organizations compensated any current or former officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (describe hours for related organizations in Schedule O) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(1) JERRY BISGROVE
BOARD MEMBER
 1.0 X           0 0 0
(2) GOVERNOR JAN BREWER
BOARD MEMBER
 1.0 X           0 0 0
(3) ROBERT BULLA
BOARD MEMBER
 1.0 X           0 0 0
(4) JOSE CARDENAS
BOARD MEMBER
 1.0 X           0 0 0
(5) BENNETT DORRANCE
BOARD MEMBER / SECRETARY
 1.0 X   X       0 0 0
(6) PETER S FINE
BOARD MEMBER
 1.0 X           0 0 0
(7) BERT GETZ
BOARD MEMBER
 1.0 X           0 0 0
(8) DAVID GULLEN MD
BOARD MEMBER
 1.0 X           0 0 0
(9) JEFFREY MOORAD
BOARD MEMBER
 1.0 X           0 0 0
(10) T LON OWEN PHD
BOARD MEMBER
 1.0 X           0 0 0
(11) CINDY PARSEGHIAN
BOARD MEMBER / TREASURER
 1.0 X   X       0 0 0
(12) WILLIAM J POST
BOARD MEMBER / CHAIRMAN
 1.0 X   X       0 0 0
(13) RICHARD SILVERMAN
BOARD MEMBER
 1.0 X           0 0 0
(14) THE HONORABLE GREG STANTON
BOARD MEMBER
 1.0 X           0 0 0
(15) JEFFREY TRENT
BM / PRES / SCIENCE DIRECTOR
 39.0 X   X         1,085,392 455,479
(16) JOHN KENNEDY
BOARD MEMBER (THRU 3/2012)
 1.0 X           0 0 0
(17) DAVID VAN ANDEL
BOARD MEMBER (THRU 3/2012)
 1.0 X           0 0 0
Form 990 (2011)
Form 990 (2011)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (describe hours for related organizations in Schedule O) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(18) TERESA BURLESON
CHIEF OPERATING OFFICER
 39.0     X       440,722 0 16,059
(19) DANIEL VON HOFF
EXECUTIVE VICE PRESIDENT
 40.0     X       684,393 0 15,717
(20) ELIZABETH MONTEMAYOR
CHIEF FINANCIAL OFFICER
 40.0     X       244,212 0 20,350
(21) SPYRO MOUSSES
VICE PRESIDENT
 40.0       X     305,359 0 18,455
(22) MICHAEL BERENS
DEPUTY DIRECTOR OF RESEARCH
 40.0       X     316,743 0 16,630
(23) DAVID DUGGAN
ASSOCIATE PROFESSOR
 40.0       X     258,844 0 20,488
(24) JAMES HARRIS
VP BUSINESS DEVELOPMENT
 40.0       X     209,984 0 21,657
(25) EDWARD SUH
CHIEF INFORMATION OFFICER
 40.0       X     275,250 0 18,118
(26) DAVID CRAIG
DEPUTY DIRECTOR INFO SCIENCES
 40.0       X     157,812   54,159
(27) JOHN CARPTEN
DEPUTY DIRECTOR OF SCIENCES
 40.0         X   242,137 0 60,462
(28) STEPHANIE MCRAE
GENERAL COUNSEL
 40.0         X   283,646 0 10,442
(29) STEPHEN GATELY
TD2 PRESIDENT / SCIENTIFIC DIR
 40.0         X   247,019 0 5,667
(30) JOHANNA DISTEFANO
PROFESSOR
 40.0         X   224,193 0 11,867
(31) GALEN PERRY
VP MARKETING/COMMUNICATIONS
 40.0         X   200,680   16,871
(32) JEFFREY NIEVES
DEPUTY DIRECTOR (THRU 11/2011)
 40.0           X 297,766 0 13,163
1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)............MediumBullet 4,388,760 1,085,392 775,584
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organizationMediumBullet62
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If “Yes,” complete Schedule J for such individual .............
3
Yes
 
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If “Yes,” complete Schedule J for such individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If “Yes,” complete Schedule J for such person .....
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
PERSISTENT SYSTEMS LTD
402E SENAPATI BAPAT RD
PUNE,PUNE411 016
IN 		SOFTWARE DEVELOPMENT 289,643
JULIE BERNARD
11076 MAPLE ROAD
LAFAYETTE,CO80026 		LEGAL SERVICES 226,621
ERNST YOUNG LLP
DEPT 6793
LOS ANGELES,CA90084 		AUDIT SERVICES 204,401
PRICEWATERHOUSECOOPERS LLP
PO BOX 514038
LOS ANGELES,CA90051 		CONSULTING SERVICES 199,250
FIRSTSTRATEGIC
300 W CLARENDON AVE STE 460
PHOENIX,AZ85013 		CONSULTING SERVICES 184,877
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet9
Form 990 (2011)
Form 990 (2011)
Page 9
Part VIII
Statement of Revenue
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512, 513, or 514
Contributions, Gifts, Grants and Other Similar Amounts 1a Federated campaigns..1a  
b Membership dues....1b  
c Fundraising events....1c  
d Related organizations...1d 8,000,000
e Government grants (contributions)1e 12,998,097
f All other contributions, gifts, grants, and
similar amounts not included above1f 		6,783,135
g Noncash contributions included in lines 1a-1f:$ 998,003
h Total. Add lines 1a-1f.......MediumBullet 27,781,232
Program Service Revenue Business Code
2a RESEARCH CONTRACTS 541,700 19,840,214 19,840,214    
b
c
d
e
f All other program service revenue .        
g Total. Add lines 2a–2f........MediumBullet 19,840,214
Other Revenue 3 Investment income (including dividends, interest
and other similar amounts).....MediumBullet 20,014     20,014
4 Income from investment of tax-exempt bond proceeds..MediumBullet 0      
5 Royalties............MediumBullet 0      
(i) Real (ii) Personal
6a Gross rents    
b Less: rental expenses    
c Rental income or (loss)    
d Net rental income or (loss).......MediumBullet        
(i) Securities (ii) Other
7a Gross amount from sales of assets other than inventory    
b Less: cost or other basis and sales expenses    
c Gain or (loss)    
d Net gain or (loss)..........MediumBullet 0      
8a Gross income from fundraising events (not including
$  
of contributions reported on line 1c). See Part IV, line 18 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from fundraising events..MediumBullet 0    
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities...MediumBullet 0      
10a Gross sales of inventory, less
returns and allowances .
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet 0      
Miscellaneous Revenue Business Code
11a ALL OTHER REVENUE 900,099 850,591 850,591    
b            
c            
d All other revenue ....        
e Total. Add lines 11a–11d ......MediumBullet 850,591
12 Total revenue. See Instructions....MediumBullet 48,492,051 20,690,805 0 20,014
Form 990 (2011)
Form 990 (2011)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A) but are not required to complete columns (B), (C), and (D).
Check if Schedule O contains a response to any question in this Part IX. .........
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to governments and organizations in the United States. See Part IV, line 21 0  
2 Grants and other assistance to individuals in the United States. See Part IV, line 22 0  
3 Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16 0  
4 Benefits paid to or for members 0  
5 Compensation of current officers, directors, trustees, and key employees .... 4,087,276 1,542,451 2,544,825  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .... 0      
7 Other salaries and wages 18,586,777 9,341,094 9,245,683  
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 672,881 322,983 349,898  
9 Other employee benefits ....... 1,733,477 832,069 901,408  
10 Payroll taxes ........... 1,515,576 727,476 788,100  
11 Fees for services (non-employees):        
a Management ...... 0      
b Legal ......... 587,042 0 587,042  
c Accounting ........... 132,090 0 132,090  
d Lobbying ........... 0      
e Professional fundraising. See Part IV, line 17.. 0  
f Investment management fees ...... 0      
g Other .......... 6,807,854 5,437,827 1,370,027  
12 Advertising and promotion .... 33,450 0 33,450  
13 Office expenses ....... 8,639,072 6,479,304 2,159,768  
14 Information technology ...... 1,315,054 657,527 657,527  
15 Royalties .. 0      
16 Occupancy ........... 6,307,888 4,730,916 1,576,972  
17 Travel ............ 636,140 254,456 381,684  
18 Payments of travel or entertainment expenses for any federal, state, or local public officials ...... 0      
19 Conferences, conventions, and meetings .... 331,727 132,691 199,036  
20 Interest ........... 305,378   305,378  
21 Payments to affiliates ....... 0      
22 Depreciation, depletion, and amortization ..... 5,191,851 3,893,888 1,297,963  
23 Insurance .............. 375,001 37,500 337,501  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24f. If line 24f amount exceeds 10% of line 25, column (A) amount, list line 24f expenses on Schedule O.)
a SEMINARS AND EDUCATION 109,437 43,775 65,662  
b DUES AND SUBSCRIPTIONS 43,873 17,549 26,324  
c RECRUITMENT 29,785 11,914 17,871  
d ALL OTHER EXPENSES 190,943 76,377 114,566  
e
f All other expenses        
25 Total functional expenses. Add lines 1 through 24f 57,632,572 34,539,797 23,092,775 0
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2011)
Form 990 (2011)
Page 11
Part X Balance Sheet
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash—non-interest-bearing .......... 4,799,497 1 6,074,770
2 Savings and temporary cash investments ....... 12,073,161 2 8,952,588
3 Pledges and grants receivable, net ......... 16,842,034 3 13,761,344
4 Accounts receivable, net ......... 1,952,991 4 153,542
5 Receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
Schedule L .......... 0 5 0
6 Receivables from other disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B). Complete Part II of
Schedule L .......... 0 6 0
7 Notes and loans receivable, net ............. 0 7 0
8 Inventories for sale or use .............. 0 8 0
9 Prepaid expenses and deferred charges ............ 992,446 9 850,957
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 40,540,987
b Less: accumulated depreciation. ..... 10b 29,507,170 13,329,023 10c 11,033,817
11 Investments—publicly traded securities .......... 0 11 0
12 Investments—other securities. See Part IV, line 11 ...... 0 12 0
13 Investments—program-related. See Part IV, line 11 .. 0 13 0
14 Intangible assets ......... 0 14 0
15 Other assets. See Part IV, line 11 ........... 614,069 15 1,687,696
16 Total assets. Add lines 1 through 15 (must equal line 34)... 50,603,221 16 42,514,714
Liabilities 17 Accounts payable and accrued expenses . 5,121,425 17 1,733,339
18 Grants payable .......... 0 18 0
19 Deferred revenue .......... 4,348,674 19 9,913,150
20 Tax-exempt bond liabilities .......... 0 20 0
21 Escrow or custodial account liability. Complete Part IV of Schedule D.. 0 21 0
22 Payables to current and former officers, directors, trustees, key
employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L.......... 0 22 0
23 Secured mortgages and notes payable to unrelated third parties .. 7,871,489 23 5,930,394
24 Unsecured notes and loans payable to unrelated third parties .... 0 24 0
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D..... 463,515 25 621,301
26 Total liabilities. Add lines 17 through 25..... 17,805,103 26 18,198,184
Net Assets or Fund Balance Organizations that follow SFAS 117, check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets ..... 13,945,385 27 13,838,624
28 Temporarily restricted net assets ..... 18,852,733 28 10,477,906
29 Permanently restricted net assets ..... 0 29 0
Organizations that do not follow SFAS 117, check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds .....   30  
31 Paid-in or capital surplus, or land, building or equipment fund .....   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ..... 32,798,118 33 24,316,530
34 Total liabilities and net assets/fund balances ..... 50,603,221 34 42,514,714
Form 990 (2011)
Form 990 (2011)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response to any question in this Part XI .........
1
Total revenue (must equal Part VIII, column (A), line 12) ...
1
48,492,051
2
Total expenses (must equal Part IX, column (A), line 25) ....
2
57,632,572
3
Revenue less expenses. Subtract line 2 from line 1 ...
3
-9,140,521
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) ..
4
32,798,118
5
Other changes in net assets or fund balances (explain in Schedule O) ...
5
658,933
6
Net assets or fund balances at end of year. Combine lines 3, 4, and 5 (must equal Part X, line 33, column (B)) ....
6
24,316,530
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response to any question in this Part XII .........
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?....
2a
 
No
b
Were the organization’s financial statements audited by an independent accountant?........
2b
Yes
 
c
If “Yes,” to 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant? If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O. ...........................
2c
Yes
 
d
If “Yes” to line 2a or 2b, check a box below to indicate whether the financial statements for the year were issued on a separate basis, consolidated basis, or both:
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133? ................
3a
Yes
 
b
If “Yes,” did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits. ..
3b
Yes
 
Form 990 (2011)
Additional Data


Software ID:  
Software Version:  
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ. right arrow See separate instructions.
OMB No. 1545-0047
2011
Open to Public
Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
f
g
(i) a person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the the supported organization? ................
11g(i)
 
 
(ii) a family member of a person described in (i) above? ......................
11g(ii)
 
 
(iii) a 35% controlled entity of a person described in (i) or (ii) above? ................
11g(iii)
 
 
h
(i)
Name of supported organization 		(ii)
EIN 		(iii)
Type of organization (described on lines 1- 9 above or IRC section (see instructions)) 		(iv)
Is the organization in col. (i) listed in your governing document? 		(v)
Did you notify the organization in col. (i) of your support? 		(vi)
Is the organization in col. (i) organized in the U.S.? 		(vii)
Amount of support?
Yes No Yes No Yes No
Total                  

For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2011
Schedule A (Form 990 or 990-EZ) 2011
Page 2
Part II
Support Schedule for Organizations Described in IRC 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year(or fiscal year beginning in) (a) 2007 (b) 2008 (c) 2009 (d) 2010 (e) 2011 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .... 48,715,607 40,267,050 50,530,395 55,961,459 27,781,232 223,255,743
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3.. 48,715,607 40,267,050 50,530,395 55,961,459 27,781,232 223,255,743
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..           12,469,915
6 Public Support. Subtract line 5 from line 4.           210,785,828
Section B. Total Support
Calendar year(or fiscal year beginning in) (a) 2007 (b) 2008 (c) 2009 (d) 2010 (e) 2011 (f) Total
7 Amounts from line 4.. 48,715,607 40,267,050 50,530,395 55,961,459 27,781,232 223,255,743
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. 230,227 492,533 56,756 329,668 20,014 1,129,198
9 Net income from unrelated business activities, whether or not the business is regularly carried on.. 65,317         65,317
10 Other income. (Explain in Part IV.) Do not include gain or loss from the sale of capital assets.. 204,892 271,807 -8,054 209,147 850,591 1,528,383
11 Total support (Add lines 7 through 10).           225,978,641
12
12
108,384,671
13
Section C. Computation of Public Support Percentage
14
14
93.277 %
15
15
89.315 %
16a
b
17a
b
18
Schedule A (Form 990 or 990-EZ) 2011
Schedule A (Form 990 or 990-EZ) 2011
Page 3
Part III
Support Schedule for Organizations Described in IRC 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year(or fiscal year beginning in) (a) 2007 (b) 2008 (c) 2009 (d) 2010 (e) 2011 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513..            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public Support (Subtract line 7c from line 6.)            
Section B. Total Support
Calendar year (or fiscal year beginning in) (a) 2007 (b) 2008 (c) 2009 (d) 2010 (e) 2011 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)            
13 Total support (Add lines 9, 10c, 11 and 12.).            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2011
Schedule A (Form 990 or 990-EZ) 2011
Page 4
Part IV
Supplemental Information. Supplemental Information. Complete this part to provide the explanation required by Part II, line 10; Part II, line 17a or 17b; or Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Explanation
 
 
 
 
Schedule A (Form 990 or 990-EZ) 2011

Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors
Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
OMB No. 1545-0047
2011
Name of organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ





Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note. Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......................... Arrow Bullet   $    
Caution. An Organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its
Form 990-EZ or on Part I, line 2, of its Form 990-PF, to certify that it does not meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2011)

Page 2
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)
Name of organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
  		Employer identification number

75-3065445
Part I
Contributors (see Instructions). Use duplicate copies of Part I if additional space is needed.
     
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
RESTRICTED
 

     
RESTRICTED
RESTRICTED  
RESTRICTED, RESTRICTED   RESTRICTED

$RESTRICTED




(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  




(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  




(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  




(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  




(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  




(Complete Part II if there is a noncash contribution.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)

Page 3
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)
Name of organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
  		Employer identification number

75-3065445
Part II
Noncash Property (see Instructions). Use duplicate copies of Part II if additional space is needed.
     
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions). 		(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)

Page 4
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)
Name of organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
  		Employer identification number

75-3065445
Part III
Exclusively religious, charitable, etc., individual contributions to section 501(c)(7), (8), or (10) organizations
that total more than $1,000 for the year. Complete columns (a) through (e) and the following line entry.
For organizations completing Part III, enter the total of exclusively religious, charitable, etc.,
contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet $  
Use duplicate copies of Part III if additional space is needed
(a) No.
from
Part I		 (b)
Purpose of gift		 (c)
Use of gift		 (d)
Description of how gift is held
 
(e)
Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b)
Purpose of gift		 (c)
Use of gift		 (d)
Description of how gift is held
 
(e)
Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b)
Purpose of gift		 (c)
Use of gift		 (d)
Description of how gift is held
 
(e)
Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b)
Purpose of gift		 (c)
Use of gift		 (d)
Description of how gift is held
 
(e)
Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2011)

Additional Data


Software ID:  
Software Version:  
SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b
SchDMd Bullet Attach to Form 990. SchDMd Bullet See separate instructions.
OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .......    
2 Aggregate contributions to (during year) ...    
3 Aggregate grants from (during year) ...    
4 Aggregate value at end of year .......    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ....................... 2a  
b Total acreage restricted by conservation easements .................. 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register .................... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................
6
Staff and volunteer hours devoted to monitoring, inspecting and enforcing conservation easements during the year SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section
170(h)(4)(B)(i) and 170(h)(4)(B)(ii)? ....................................
9
In Part XIV, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of
art, historical treasures, or other similar assets held for public exhibition, education or research in furtherance of public service,
provide, in Part XIV, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art,
historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service,
provide the following amounts relating to these items:
(i)
Revenues included in Form 990, Part VIII, line 1 ........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ..............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958), relating to these items:
a
Revenues included in Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990
Cat. No. 52283D
Schedule D (Form 990) 2011

Schedule D (Form 990) 2011
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s accession and other records, check any of the following that are a significant use of its collection
items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIV.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b
If "Yes," explain the arrangement in Part XIV and complete the following table:
Amount
c Beginning balance ................................. 1c  
d Additions during the year .............................. 1d  
e Distributions during the year ............................. 1e  
f Ending balance ................................... 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21? .....................
b
If “Yes,” explain the arrangement in Part XIV.
Part V
Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.
(a)Current Year (b)Prior Year (c)Two Years Back (d)Three Years Back (e)Four Years Back
1a Beginning of year balance .... 6,331,923 6,676,003 6,373,964 6,309,126
b Contributions ........       10,000
c Net investment earnings, gains, and losses ... 643,547 550,880 786,808 422,245
d Grants or scholarships .....        
e Other expenditures for facilities
and programs ........ 		421,940 894,960 484,769 367,407
f Administrative expenses ....        
g End of year balance ...... 6,553,530 6,331,923 6,676,003 6,373,964
2
Provide the estimated percentage of the year end balance (line 1g) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Temporarily restricted endowment SchDMd Bullet100.000 %
The percentages in lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations ........................
3a(i)
 
No
(ii) related organizations ........................
3a(ii)
Yes
 
b
If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
Yes
 
4
Describe in Part XIV the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis (investment) (b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .................      
b Buildings ................        
c Leasehold improvements ............   5,137,147 1,961,176 3,175,971
d Equipment ................   30,455,525 23,273,818 7,181,707
e Other .................   4,948,315 4,272,176 676,139
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).).......SchDMdBullet 11,033,817
Schedule D (Form 990) 2011

Schedule D (Form 990) 2011
Page 3
Part VII
Investments—Other Securities. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c) Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
Other








Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet  
Part VIII
Investments—Program Related. See Form 990, Part X, line 13.
(a) Description of investment type (b) Book value (c) Method of valuation:
Cost or end-of-year market value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. See Form 990, Part X, line 15.
(a) Description (b) Book value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities. See Form 990, Part X, line 25.
1.(a) Description of Liability (b) Book value
Federal Income Taxes 0
DUE TO EMPLOYEE 457(B) PLAN 621,301








Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 621,301
2. Fin 48 (ASC 740) Footnote. In Part XIV, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC740).
Schedule D (Form 990) 2011

Schedule D (Form 990) 2011
Page 4
Part XI Reconciliation of Change in Net Assets from Form 990 to Financial Statements
1 Total revenue (Form 990, Part VIII, column (A), line 12) .................... 1  
2 Total expenses (Form 990, Part IX, column (A), line 25) ..................... 2  
3 Excess or (deficit) for the year. Subtract line 2 from line 1 ............. 3  
4 Net unrealized gains (losses) on investments .......................... 4  
5 Donated services and use of facilities ............................. 5  
6 Investment expenses ................................... 6  
7 Prior period adjustments .................................. 7  
8 Other (Describe in Part XIV.) ................................. 8  
9 Total adjustments (net). Add lines 4 through 8 ......................... 9  
10 Excess or (deficit) for the year per financial statements. Combine lines 3 and 9 ......... 10  
Part XII Reconciliation of Revenue per Audited Financial Statements With Revenue per Return
1 Total revenue, gains, and other support per audited financial statements ....... 1  
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains on investments .......... 2a  
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIV.) ............ 2d  
e Add lines 2a through 2d ..................... 2e  
3 Subtract line 2e from line 1..................... 3  
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a  
b Other (Describe in Part XIV.) ........... 4b  
c Add lines 4a and 4b....................... 4c  
5 Total Revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5  
Part XIII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return
1 Total expenses and losses per audited financial statements ............. 1  
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities .......... 2a  
b Prior year adjustments .............. 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIV.) ............ 2d  
e Add lines 2a through 2d...................... 2e  
3 Subtract line 2e from line 1..................... 3  
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a  
b Other (Describe in Part XIV.) ............ 4b  
c Add lines 4a and 4b....................... 4c  
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5  
Part XIV
Supplemental Information
Complete this part to provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X; Part XI, line 8; Part XII, lines 2d and 4b; and Part XIII, lines 2d and 4b. Also complete this part to provide any additional information.
Identifier Return Reference Explanation
SCHEDULE D, PART V - ENDOWMENTS   TGEN'S POLICY FOR APPROPRIATING THE DISTRIBUTION OF ITS SUMMER INTERNSHIP PROGRAM ENDOWMENT HAS BEEN DESIGNED TO SUPPORT A SPECIFIC NUMBER OF SUMMER INTERNS EACH YEAR FOR THE NEXT 25 YEARS. THE INSTITUTE CONSIDERED THE LONG-TERM EXPECTED RETURN ON ITS ENDOWMENT.
SCHEDULE D, PART X - FIN 48 (ASC 740) FOOTNOTE   MANAGEMENT IS OF THE OPINION THAT SUBSTANTIALLY ALL OF TGEN'S AND THE FOUNDATION'S ACTIVITIES ARE RELATED TO THEIR EXEMPT PURPOSES, AND NO MATERIAL UNCERTAIN TAX POSITIONS HAVE BEEN IDENTIFIED OR RECORDED IN THE ACCOMPANYING CONSOLIDATED FINANCIAL STATEMENTS AT DECEMBER 31, 2012. TGEN AND THE FOUNDATION FILE FORMS 990 IN THE U.S. FEDERAL JURISDICTION AND COMPARABLE FORMS IN THE STATE OF ARIZONA. TAX FILINGS FOR 2008 THROUGH 2011 ARE SUBJECT TO EXAMINATION; HOWEVER, THE INSTITUTE HAS NOT BEEN NOTIFIED OF ANY SUCH EXAMINATIONS.
Schedule D (Form 990) 2011

Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.
OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
General Information on Activities Outside the United States. Complete if the organization answered
“Yes” to Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants
and other assistance, the grantees' eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? ..............................
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other
assistance outside the United States.
3
Activites per Region. (Use Part V if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees or agents in region or independent contractors (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total
expenditures for region/investments
in region
Europe (Including Iceland and Greenland) 0 0 Program Services SOFTWARE DEVELOPMENT 370,000
           
           
           
           
           
           
           
           
           
           
           
           
           
           
           
           
3a Sub-total ..... 0 0 370,000
b Total from continuation sheets to Part I ...      
c Totals (add lines 3a and 3b) 0 0 370,000
For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2011
Schedule F (Form 990) 2011
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" to Form 990,
Part IV, line 15, for any recipient who received more than $5,000. Check this box if no one recipient received more than $5,000 ........ MediumBullet
Use Part V if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount of
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2
Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .....MediumBullet
 
3
Enter total number of other organizations or entities ........................MediumBullet
 
Schedule F (Form 990) 2011
Schedule F (Form 990) 2011Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Use Part V if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2011
Schedule F (Form 990) 2011
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926 (see instructions for Form 926).................
2 Did the organization have an interest in a foreign trust during the tax year? If " Yes," the organization may be required to file Form 3520 and/or Form 3520-A. (see instructions for Forms 3520 and 3520-A)..........
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with respect to Certain Foreign Corporations. (see instructions for Form 5471)..............................
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If "Yes," the organization may be required to file Form 8621, Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see instructions for Form 8621)
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with respect to Certain Foreign Partnerships. (see instructions for Form 8865)....................................
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see instructions for Form 5713)................................................
Schedule F (Form 990) 2011
Schedule F (Form 990) 2011
Page 5
Part V
Supplemental Information
Complete this part to provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).
Identifier ReturnReference Explanation
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
Schedule F (Form 990) 2011
Additional Data


Software ID:  
Software Version:  



Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" to Form 990,
Part IV, question 23.
SchJMediumBullet Attach to Form 990. SchJMediumBullet See separate instructions.
OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all the expenses described above? If "No," complete Part III to explain....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
officers, directors, trustees, and the CEO/Executive Director, regarding the items checked in line 1a? ....
2
Yes
 
3
Indicate which, if any, of the following the organization uses to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ...............
4a
Yes
 
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? ........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? ........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.
5
For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization? .........................
5b
 
No
If "Yes," to line 5a or 5b, describe in Part III.
6
For persons listed in form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ...........................
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," to line 6a or 6b, describe in Part III.
7
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
 
No
9
If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Privacy Act and Paperwork Reduction Act Notice, see the Intructions for Form 990
Cat. No. 50053T
Schedule J (Form 990) 2011

Schedule J (Form 990) 2011
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.

Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and column (E) for that individual.
(A) Name (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation
reported as deferred
in prior Form 990
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
(1) TERESA BURLESON (i)
(ii)		 381,110
0 		57,830
0 		1,782
0 		9,744
0 		6,315
0 		456,781
0 		0
0
(2) DANIEL VON HOFF (i)
(ii)		 614,683
0 		64,946
0 		4,764
0 		9,800
0 		5,917
0 		700,110
0 		0
0
(3) SPYRO MOUSSES (i)
(ii)		 250,718
0 		53,083
0 		1,558
0 		9,750
0 		8,705
0 		323,814
0 		0
0
(4) JOHN CARPTEN (i)
(ii)		 217,849
0 		22,666
0 		1,622
0 		51,837
0 		8,625
0 		302,599
0 		0
0
(5) MICHAEL BERENS (i)
(ii)		 238,626
0 		41,695
0 		36,422
0 		9,750
0 		6,880
0 		333,373
0 		0
0
(6) DAVID DUGGAN (i)
(ii)		 204,013
0 		53,553
0 		1,278
0 		9,770
0 		10,718
0 		279,332
0 		0
0
(7) STEPHANIE MCRAE (i)
(ii)		 223,926
0 		41,321
0 		18,399
0 		9,760
0 		682
0 		294,088
0 		0
0
(8) JAMES HARRIS (i)
(ii)		 170,773
0 		20,050
0 		19,161
0 		12,140
0 		9,517
0 		231,641
0 		0
0
(9) JEFFREY NIEVES (i)
(ii)		 179,646
0 		74,332
0 		43,788
0 		9,760
0 		3,403
0 		310,929
0 		0
0
(10) ELIZABETH MONTEMAYOR (i)
(ii)		 219,291
0 		22,820
0 		2,101
0 		9,756
0 		10,594
0 		264,562
0 		0
0
(11) EDWARD SUH (i)
(ii)		 219,253
0 		25,371
0 		30,626
0 		9,760
0 		8,358
0 		293,368
0 		0
0
(12) STEPHEN GATELY (i)
(ii)		 212,981
0 		32,596
0 		1,442
0 		0
0 		5,667
0 		252,686
0 		0
0
(13) JOHANNA DISTEFANO (i)
(ii)		 201,951
0 		20,512
0 		1,730
0 		9,012
0 		2,855
0 		236,060
0 		0
0
(14) JEFFREY TRENT (i)
(ii)		  
990,045 		 
0 		 
95,347 		211,539
242,500 		 
1,440 		211,539
1,329,332 		0
0
(15) GALEN PERRY (i)
(ii)		 180,153
  		18,731
  		1,796
  		8,278
  		8,593
  		217,551
  		0
 
(16) DAVID CRAIG (i)
(ii)		 155,121
  		1,500
  		1,191
  		48,774
  		5,385
  		211,971
  		0
 
Schedule J (Form 990) 2011

Schedule J (Form 990) 2011
Page 3
Part III
Supplemental Information
Complete this part to provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4c, 5a, 5b, 6a, 6b, 7, and 8. Also complete this part for any additional information.
Identifier Return Reference Explanation
SCHEDULE J, PART I, LINE 1A   FIRST CLASS TRAVEL IS PERMITTED BY EXECUTIVE STAFF ONLY AND MUST, BY TGEN POLICY, BE PRE-APPROVED BY THE CHIEF OPERATING OFFICER. TGEN DOES PROVIDE MEMBERSHIP TO DR. TRENT AT THE PARADISE VALLEY COUNTRY CLUB. THIS EXPENSE WAS PRE-APPROVED BY THE CHIEF OPERATING OFFICER. THESE EXPENSES WERE NOT CONSIDERED AS TAXABLE COMPENSATION TO THE RECIPIENT. THE COUNTRY CLUB MEMBERSHIP REIMBURSEMENT IS FOR BUSINESS PURPOSES ONLY. SCHEDULE J, PART I, LINE 4A JEFFREY NIEVES RECEIVED SEVERANCE PAYMENTS IN THE AMOUNT OF $28,953 WHICH HAVE BEEN INCLUDED IN PART II, COL B(III).
SCHEDULE J, PART I, LINE 7   SOME OF THE PERSONS LISTED IN FORM 990, PART VII WERE PAID BONUSES WHICH WERE BASED ON ACCOMPLISHMENTS OF SPECIFIC MILESTONES AND/OR PERFORMANCE BASES.
SCHEDULE J, PART II   DEFERRED COMPENSATION INCLUDES RETENTION AGREEMENTS FOR THE PRESIDENT AND CHIEF SCIENTIFIC OFFICER OF THE INSTITUTE (DR. JEFFREY TRENT) AND TWO DEPUTY DIRECTORS (JOHN CARPTEN AND DAVID CRAIG). DR. TRENT IS ELIGIBLE TO RECEIVE $500,000 ON 3/12/2017 AND THE DEPUTY DIRECTORS ARE ELIGIBLE TO RECEIVE $192,000 EACH ON 11/30/2015 PAYABLE BY TGEN. AMOUNTS ACCRUED BY TGEN DURING CALENDAR YEAR 2011 UNDER THESE AGREEMENTS HAVE BEEN REPORTED IN PART II, COL C AS DEFERRED COMPENSATION AS FOLLOWS: TRENT $211,539 CARPTEN $ 42,308 CRAIG $ 42,308 DR. TRENT IS PAID BY VARI, A RELATED TAX-EXEMPT ORGANIZATION. A PORTION OF HIS SALARY IS THEN REIMBURSED BY TGEN FOR SERVICES RENDERED TO TGEN. HIS DEFERRED COMPENSATION INCLUDES $242,500 ACCRUED BY VARI DURING THE YEAR.
Schedule J (Form 990) 2011

Additional Data


Software ID:  
Software Version:  
Schedule L
(Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Transactions with Interested Persons
MediumBullet Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V lines 38a or 40b.
MediumBullet Attach to Form 990 or Form 990-EZ. MediumBulletSee separate instructions.
OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Excess Benefit Transactions (section 501(c)(3) and section 501 (c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1(a) Name of disqualified person (b) Description of transaction (c) Corrected?
Yes No





2
Enter the amount of tax imposed on the organization managers or disqualified persons during the year under section 4958. ......................... Bullet Image$
 
3
Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image$
 

Part II
Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 26, or Form 990-EZ, Part V, line 38a.
(a) Name of interested person and purpose (b) Loan to or from the organization? (c)Original principal amount (d)Balance due (e) In default? (f) Approved by board or committee? (g)Written agreement?
To From Yes No Yes No Yes No
Total ...............Small Bullet $  
Part III
Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.
(a) Name of interested person (b)Relationship between interested person and the organization (c)Amount of grant or type of assistance
For Privacy Act and Paperwork Reduction Act Notice, see the
Instructions for Form 990 or 990-EZ.
Cat. No. 50056A
Schedule L (Form 990 or 990-EZ) 2011
Schedule L (Form 990 or 990-EZ) 2011
Page 2
Part IV
Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of transaction (d) Description of transaction (e) Sharing of organization's revenues?
Yes No
(1) PINNACLE WEST CAPITAL WILLIAM POST/CEO 154,832 INVESTMENT SERVICES   No
(2) 5AM SOLUTIONS DANIEL VAN HOFF/DIRECTOR 222,159 TECHNICAL CONSULTING   No
(3) ABRAXIS BIOSCIENCE DANIEL VAN HOFF/DIRECTOR 126,369 SCIENTIFIC ADVISORY BOARD   No
(4) ESPERANCE DANIEL VAN HOFF/DIRECTOR 65,560 SCIENTIFIC ADVISORY BOARD   No
(5) TECH66 WILLIAM BURLESON SPOUSE OF OFFICER 129,246 CONSULTANT ON SOFTWARE PROJECT   No
Part V
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule L (see instructions).
Identifier Return Reference Explanation
Schedule L (Form 990 or 990-EZ) 2011

Additional Data


Software ID:  
Software Version:  




SCHEDULE M
(Form 990)

Department of the Treasury
Internal Revenue Service
NonCash Contributions
Right pointing arrow large imageComplete if the organization answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image Attach to Form 990.
OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Types of Property
(a)
Check if applicable 		(b)
Number of Contributions or items contributed 		(c)
Noncash contribution amounts reported on
Form 990, Part VIII, line 1g 		(d)
Method of determining
noncash contribution amounts
1 Art—Works of art ....        
2 Art—Historical treasures .        
3 Art—Fractional interests ..        
4 Books and publications ..      
5 Clothing and household
goods ....... 		     
6 Cars and other vehicles ..        
7 Boats and planes ....        
8 Intellectual property ...        
9 Securities—Publicly traded .        
10 Securities—Closely held stock .        
11 Securities—Partnership, LLC,
or trust interests .... 		       
12 Securities—Miscellaneous ..        
13 Qualified conservation
contribution—Historic
structures ..... 		       
14 Qualified conservation
contribution—Other ... 		       
15 Real estate—Residential .        
16 Real estate—Commercial ..        
17 Real estate—Other ...        
18 Collectibles .....        
19 Food inventory ...        
20 Drugs and medical supplies .        
21 Taxidermy ......        
22 Historical artifacts ....        
23 Scientific specimens ..        
24 Archeological artifacts ...        
25 Other Right pointing arrow large image ( OTHER (ATCH 1) ) X 5 998,003 COST OR SALES PRICE
26 Other Right pointing arrow large image( )
27 Other Right pointing arrow large image( )
28 Other Right pointing arrow large image ( )
29
Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement ...
29
 
Yes
No
30a
During the year, did the organization receive by contribution any property reported in Part I, lines 1-28 that it
must hold for at least three years from the date of the initial contribution, and which is not required to be used
for exempt purposes for the entire holding period? ..................
30a
 
No
b
If "Yes," describe the arrangement in Part II.
31
Does the organization have a gift acceptance policy that requires the review of any non-standard contributions?
31
 
No
32a
Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash
contributions? ............................
32a
 
No
b
If "Yes," describe in Part II.
33
If the organization did not report revenues in column (c) for a type of property for which column (a) is checked,
describe in Part II.
For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 51227J
Schedule M (Form 990) 2011
Schedule M (Form 990) 2011
Page 2
Part II
Supplemental Information. Complete this part to provide the information required by Part I, lines 30b,
32b, and 33 and whether the organization is reporting in Part I, column (b) the number of contributions, the number of items received, or a combination of both. Also complete this part for any additional information.
Identifier Return Reference Explanation
SCHEDULE M, PART I OTHER NONCASH CONTRIBUTIONS SEQUENCING EQUIPMENT, 3 ITEMS, REVENUES REPORTED $248,773; COMPUTER EQUIPMENT, 1 ITEM, REVENUES REPORTED $704,922; DISCOUNT ON LOAN, 1 ITEM, REVENUES REPORTED $44,308; TOTAL $998,003
Schedule M (Form 990) 2011
Additional Data


Software ID:  
Software Version:  
SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
OMB No. 1545-0047
2011
Open to Public
Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Identifier Return Reference Explanation
ORGANIZATION'S MISSION STATEMENT FORM 990, PART I, LINE 1, AND PART III, LINE 1 THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN) IS A NONPROFIT BIOMEDICAL RESEARCH INSTITUTE FOCUSED ON DEVELOPING EARLIER DIAGNOSTICS AND SMARTER TREATMENTS BY EMPLOYING INNOVATIVE ADVANCES ARISING FROM THE HUMAN GENOME PROJECT AND APPLYING THEM TO THE DEVELOPMENT OF DIAGNOSTICS, PROGNOSTICS AND THERAPIES FOR CANCER, NEUROLOGICAL DISORDERS, DIABETES AND OTHER COMPLEX DISEASES. DESCRIPTION OF PROGRAM SERVICE ACCOMPLISHMENTS FORM 990, PART III, LINES 4A - 4C LINE 4A - PROGRAM SERVICE ACTIVITY #1 TGEN CLINICAL RESEARCH SERVICES CLINICIANS FOCUS ON CLINICAL TRIALS WITH TARGETED AGENTS AND GENOMICS-BASED INDIVIDUALIZED THERAPY. THE TCRS, WITH AN INITIAL FOCUS ON CANCER, ALLOWS THE UNIQUE OPPORTUNITY FOR TGEN TO TRANSITION ITS LABORATORY-BASED RESEARCH TO PATIENT CARE CENTERED ON INDIVIDUALIZED THERAPY. LINE 4B - PROGRAM SERVICE ACTIVITY #2 TGEN'S CANCER AND CELL BIOLOGY DIVISION IS WORKING TO DISCOVER VALID MARKERS AND THERAPEUTIC TARGETS FOR TREATING HUMAN DISEASE. THE DIVISION SUPPORTS LAB PROGRAMS IN BREAST CANCER, MELANOMA, LUNG CANCER, HEAD AND NECK TUMORS AS WELL AS BOTH PRIMARY AND METASTATIC BRAIN TUMORS. LINE 4C - PROGRAM SERVICE ACTIVITY #3 TGEN'S GENOTYPING TECHNOLOGY CENTER ANALYZES BITS OF DNA CALLED SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) WHICH GIVE RESEARCHERS THE POWER TO IDENTIFY DISEASE-CAUSING GENES, ASSOCIATIONS, AND DNA SIGNATURES, ALL OF WHICH HAVE PROFOUND IMPLICATIONS FOR DETECTION, PROGNOSIS AND THERAPEUTIC INTERVENTION. THE SNP GENOTYPING CENTER OFFERS INNOVATIVE SOLUTIONS THAT ADDRESS THE REQUIREMENTS FOR FLEXIBILITY, SIMPLICITY, THROUGHPUT, ECONOMY, AND ACCURACY. LINE 4D - OTHER PROGRAM SERVICES INTRODUCTION TGEN CELEBRATED ITS 10TH ANNIVERSARY IN 2012. IT WAS IN FEBRUARY 2002 THAT AN ASSEMBLY OF MORE THAN 50 ARIZONA LEADERS AND VISIONARIES IN SCIENCE, MEDICINE, GOVERNMENT AND BUSINESS GATHERED AT THE ARIZONA STATE CAPITOL TO DISCUSS THE POSSIBILITY OF ESTABLISHING ARIZONA AS A SIGNIFICANT PLAYER IN THE NEW KNOWLEDGE-BASED ECONOMY OF THE BIOMEDICAL-BIOTECHNOLOGY INDUSTRY. AS TGEN ENTERS ITS SECOND DECADE, THE INSTITUTE CONTINUES TO DEFINE ITSELF BY EMPHASIZING WHAT WE CAN DO FOR PATIENTS TODAY. THE PROSPECTS FOR INCREASINGLY SIGNIFICANT LABORATORY DISCOVERIES AND OUR TRANSLATION OF THAT NEW SCIENCE INTO CLINICAL BENEFITS FOR PATIENTS WHO HAVE NO TIME TO WAIT HEIGHTEN OUR SENSE OF URGENCY.
A NUMBER OF OUR MOST RECENT COLLABORATIONS POINT TO THIS EXCITING NEW ERA OF GENOMIC MEDICINE. THESE INCLUDE: - A MULTI-YEAR, MULTI-MILLION-DOLLAR CONTRACT WITH THE MULTIPLE MYELOMA RESEARCH FOUNDATION TO TRACK CHANGES IN THE GENOMES (DNA) OF AN UNPRECEDENTED 1,000-PATIENT NATIONAL STUDY OF THIS BONE MARROW CANCER. - OUR CLINICAL TRIALS PROGRAM, IN PARTNERSHIP WITH SCOTTSDALE HEALTHCARE AND BIND BIOSCIENCES, SHOWED THE SUCCESSFUL FIRST USE OF NANOPARTICLES, MICROSCOPIC DRONES, TO DELIVER TARGETED MEDICINES, SHRINKING AND EVEN ELIMINATING PATIENTS' TUMORS, ACCORDING TO A STUDY REPORTED IN THE JOURNAL SCIENCE TRANSLATIONAL MEDICINE AND PRESENTED AT THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). - AS REPORTED IN THE NEW ENGLAND JOURNAL OF MEDICINE, TGEN AND ITS COLLABORATORS IDENTIFIED THE FIRST MAJOR GENE MUTATION ASSOCIATED WITH HEREDITARY PROSTATE CANCER, FOLLOWING A 20-YEAR QUEST TO DISCOVER A GENETIC DRIVER FOR THIS DISEASE. - IN FEBRUARY, VISMODEGIB BECAME THE FIRST DRUG TESTED AT TGEN'S CLINIC TRIALS PROGRAM TO RECEIVE FDA APPROVAL. THIS ALSO WAS THE FIRST DRUG APPROVED BY THE FDA TO TREAT INOPERABLE BASAL CELL CARCINOMA, A TYPE OF SKIN CANCER PREVALENT IN ARIZONA. IN ADDITION, WE ANTICIPATE CONTINUING AND STRONGER COLLABORATIONS WITH ALL OUR MAJOR PARTNERS, SIGNIFICANT NEW OPPORTUNITIES WITH BIOTECH AND BIOPHARMA INDUSTRIES, AND AN ACCELERATION OF PROGRESS IN THE AREA OF COMMERCIALIZATION. TGEN'S NEW CLIA (CLINICAL LABORATORY IMPROVEMENT AMENDMENTS) LABORATORY -NAMED THE DORRANCE CLINICAL LABORATORY- ON THE 4TH FLOOR OF OUR HEADQUARTERS BUILDING ENHANCES MANY OF THESE INITIATIVE BY STREAMLINING OUR ABILITY TO PROVIDE ONCOLOGISTS WITH TIMELY GENOMIC ANALYSIS AND ACCELERATE PATIENT BENEFIT. THIS MEANS TGEN NO LONGER NEEDS TO VALIDATE ITS GENOMIC FINDINGS THROUGH AN OUTSIDE CLIA LAB BEFORE SHARING THE RESULTS WITH ONCOLOGISTS AND THEIR PATIENTS. CHIEF AMONG THESE IS THE ANNOUNCEMENT IN JULY OF $10 MILLION IN GRANTS FROM THE BEN & CATHERINE IVY FOUNDATION TO FUND TWO MULTI-YEAR PROJECTS THAT AIM TO DISCOVER THE GENOMIC ORIGINS OF GLIOBLASTOMA, A BRAIN CANCER WITH FEW TREATMENT OPTIONS FOR PATIENTS. AS PART OF THESE PROJECTS, CLINICAL TRIALS WILL TEAM US WITH SOME OF THE NATION'S MORE ESTABLISHED RESEARCH CENTERS, INCLUDING MEMORIAL SLOAN KETTERING CANCER CENTER, AND THE DANA-FARBER/HARVARD CANCER CENTER. IN EARLY OCTOBER, TGEN ANNOUNCED THE FORMATION OF THE TGEN CENTER FOR RARE CHILDHOOD DISORDERS -DUBBED C4RCD. THIS NEW CENTER CREATES A FOCAL POINT - FOR THE PUBLIC, OUR PARTNERS, AND MOST IMPORTANTLY OUR PATIENTS AND THEIR FAMILIES - WHERE WE CAN BEGIN TO UNLOCK THE MYSTERIES BEHIND THE DISEASES AND CONDITIONS, MANY OF THEM UNNAMED, WHICH FOR TOO LONG HAVE BEEN INSUFFICIENTLY ADDRESSED. WHILE MANY OF THESE CONDITIONS AFFECT ONLY A FEW CHILDREN, COLLECTIVELY THEY ACCOUNT FOR THOUSANDS OF CHILDREN IN ARIZONA AND ACROSS THE NATION. IN NOVEMBER, TGEN LAUNCHED THE KIRSTEN'S LEGACY WEBSITE, IN MEMORY OF PATIENT AND TGEN ADVOCATE KIRSTEN SANDSTROM. THE WEBSITE PROVIDES PATIENTS AND THEIR FAMILIES WITH 24-7 ACCESS TO ESSENTIAL AND COMPREHENSIVE INFORMATION ON ADRENOCORTICAL CARCINOMA (ACC), A RARE AND DEADLY FORM OF CANCER. KIRSTEN'S LEGACY IS TGEN'S RESEARCH AND CLINICAL PROGRAM FOR DEFEATING ACC, PROVIDING VALUABLE PATIENT RESOURCES AND THE LATEST UPDATES ON PROGRESS MADE BY TGEN RESEARCHERS AND CLINICIANS. THE WEBSITE AND ACTIVITIES SURROUNDING IT BUILD ON THE FOUNDING ACC EFFORTS OF TROY RICHARDS, WHOSE EFFORTS ENABLED TGEN TO ESTABLISH A NATIONAL RESEARCH-FUND INITIATIVE FOR THIS RARE BUT DEADLY DISEASE. THESE AND OTHER PROJECTS WILL TAKE FULL ADVANTAGE OF TGEN'S RECOGNIZED EXPERTISE IN GENOMIC RESEARCH, AND WILL ONLY STRENGTHEN TIES WITH OUR MANY COLLABORATORS IN ARIZONA, ACROSS THE NATION, AND AROUND THE WORLD, HELPING ENABLE ARIZONA'S BIOMEDICAL INDUSTRY TO CONTINUE ITS POSITIVE GROWTH. IN ADDITION, THE FOLLOWING OVERVIEW PROVIDES A SNAPSHOT OF RECENT PROGRESS IN SCIENTIFIC PUBLICATIONS, GRANTS, CONTRACTS, PHILANTHROPY, EDUCATION AND OUTREACH, MEDIA AND COMMUNITY RECOGNITION. PEER-REVIEWED LABORATORY RESEARCH PUBLICATIONS AND PRESENTATIONS SINCE ITS INCEPTION, TGEN'S BIOMEDICAL RESEARCH HAS FOCUSED ON THE PATIENT AS AN END POINT. TGEN FACULTY WORK TO DISCOVER THE UNDERLYING CAUSE OF DISEASE PROGRESSION AND RESISTANCE TO THERAPY AND WHY SOME INDIVIDUALS ENCOUNTER DEBILITATING DISEASES AND OTHERS LIVE HEALTHY LIVES. DRIVEN BY THE LATEST TECHNOLOGY, TGEN EFFORTS REMAIN EQUAL TO THE STRENGTHS AND CAPABILITIES OF ANY OF TODAY'S LEADING RESEARCH AND CLINICAL INSTITUTES. NOWHERE IS THIS MORE EVIDENT THAN WITH TGEN'S WHOLE GENOME SEQUENCING CAPABILITIES. WHOLE GENOME SEQUENCING ALLOWS US TO DIG DEEPER INTO THE GENOME THAN EVER BEFORE BY PROVIDING MORE INFORMATION AND INCREASING OUR PROBABILITY OF IDENTIFYING SOMETHING SIGNIFICANT. THE LONG-TERM HOPE IS THAT DOCTORS WILL LEVERAGE THIS INFORMATION TO INFORM DECISIONS ABOUT PATIENT CARE. THE RESULTS FROM THESE RESEARCH STUDIES APPEAR IN A NUMBER OF LEADING SCIENTIFIC AND MEDICAL JOURNALS, AND ADD TO THE GROWING KNOWLEDGE BASE OF MOLECULAR RESEARCH AND MEDICINE. IN 2012, TGEN RESEARCHERS PUBLISHED THEIR RESEARCH RESULTS IN NUMEROUS SCHOLARLY PEER-REVIEWED ACADEMIC JOURNALS AND THROUGH PRESENTATIONS AT LEADING NATIONAL AND INTERNATIONAL CONFERENCES. THESE INCLUDE PUBLICATION IN LEADING SCIENTIFIC JOURNALS SUCH AS NEW ENGLAND JOURNAL OF MEDICINE, PROSTATE, PLOS, BLOOD, JOURNAL OF CANCER, JOURNAL OF CLINICAL ONCOLOGY, AND A HOST OF OTHER DISEASE-ASSOCIATED PUBLICATIONS.
SELECT HIGHLIGHTS FOR 2012   1. IN A STUDY OF 144 PATIENTS WITH ADVANCED CANCER, INCLUDING COLORECTAL, OTHER GASTROINTESTINAL AND PROSTATE CANCERS, RESEARCHERS AT TGEN AND SCOTTSDALE HEALTHCARE DOCUMENTED A STATISTICALLY SIGNIFICANT DECREASE IN PROGRESSION-FREE SURVIVAL WITH EACH SUCCESSIVE STANDARD THERAPY. THE STUDY PUBLISHED NOV. 28 IN THE JOURNAL OF CANCER CONCLUDED THAT NEW THERAPIES THAT REVERSE THIS TREND MIGHT LEAD TO IMPROVED CLINICAL OUTCOMES. CITATION: "PROGRESSION-FREE SURVIVAL DECREASES WITH EACH SUBSEQUENT THERAPY IN PATIENTS PRESENTING FOR PHASE I CLINICAL TRIALS." CHRISTOPHER H. BAILEY, GAYLE JAMESON, CHAO SIMA, SHARON FLECK, ERICA WHITE, DANIEL D. VON HOFF, GLEN J. WEISS. J CANCER 2012; 3:7-13. 2. A TGEN STUDY PUBLISHED NOV. 22 IN THE JOURNAL LUNG CANCER SHOWED THAT KEY DOWNSTREAM COMPONENTS OF THE HEDGEHOG SIGNALING PATHWAY (HHSP), WHICH HAS BEEN IMPLICATED IN THE DEVELOPMENT OF MULTIPLE CANCERS, SHOW CORRELATION WITH SONIC HEDGEHOG LIGAND (SHH) EXPRESSION, SUGGESTING THAT LIGAND-DEPENDENT SIGNALING IS MORE PREVALENT IN PRIMARY NON-SMALL CELL LUNG CANCER TUMORS. CITATION: RAZ G, ALLEN KE, KINGSLEY C, CHERNI I, ARORA S, WATANABE A, LORENZO CD, EDWARDS V DK, SRIDHAR S, HOSTETTER G, WEISS GJ. "HEDGEHOG SIGNALING PATHWAY MOLECULES AND ALDH1A1 EXPRESSION IN EARLY-STAGE NON-SMALL CELL LUNG CANCER." DOI:10.1016/J.LUNGCAN.2011.10.015. 3. AN ABSTRACT PREPARED BY TGEN AND OTHERS AND PRESENTED IN DECEMBER AT THE 2011 CTRC-AACR SAN ANTONIO BREAST CANCER SYMPOSIUM SHOWED THE VALUE OF WHOLE-GENOME SEQUENCING. RESEARCHERS AT TGEN COLLABORATED WITH US ONCOLOGY, LIFE TECHNOLOGIES AND BAYLOR'S CHARLES A. SAMMONS CANCER CENTER AND FOUND AN IMPRESSIVE RESPONSE TO AN INHIBITOR OF THE MEK/AKT CELLULAR PATHWAY IN TRIPLE-NEGATIVE BREAST CANCER. CITATION: JOYCE A. O'SHAUGHNESSY, DAVID W. CRAIG, JEFFREY KIEFER, SHRIPAD SINARI, TRACY M. MOSES, SHUKMEI WONG, JESSICA ALDRICH, ALEXIS CHRISTOFORIDES, JENNIFER DINH, TYLER ITZATT, JOANNE BLUM, AHMET KURDOGLU, BODOUR SALHIA, ANGELA BAKER, ASIM SIDDIQUI, LINH HOANG, PAUL BILLINGS, JEFFREY M. TRENT, SPYRO MOUSSES, DANIEL VON HOFF, JOHN D. CARPTEN. ABSTRACT TITLE: "NEXT GENERATION SEQUENCING REVEALS CO-ACTIVATING EVENTS IN THE MAPK AND PI3K/AKT PATHWAYS IN METASTATIC TRIPLE NEGATIVE BREAST CANCERS." 4. IN A STUDY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE, THE HOXB13 G84E VARIANT IS ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF HEREDITARY PROSTATE CANCER. ALTHOUGH THE VARIANT ACCOUNTS FOR A SMALL FRACTION OF ALL PROSTATE CANCERS, THIS FINDING HAS IMPLICATIONS FOR PROSTATE-CANCER RISK ASSESSMENT AND MAY PROVIDE NEW MECHANISTIC INSIGHTS INTO THIS COMMON CANCER. CITATION: "GERMLINE MUTATIONS IN HOXB13 AND PROSTATE-CANCER RISK." CHARLES M. EWING, M.S., ANNA M. RAY, M.S., ETHAN M. LANGE, PH.D., KIMBERLY A. ZUHLKE, B.A., CHRISTIANE M. ROBBINS, M.S., WAIBHAV D. TEMBE, PH.D., KATHLEEN E. WILEY, M.S., SARAH D. ISAACS, M.S., DORHYUN JOHNG, B.A., YUNFEI WANG, M.S., CHRIS BIZON, PH.D., GUIFANG YAN, B.S., MARTA GIELZAK, B.A., ALAN W. PARTIN, M.D., PH.D., VIJAYALAKSHMI SHANMUGAM, PH.D., TYLER IZATT, M.S., SHRIPAD SINARI, M.S., DAVID W. CRAIG, PH.D., S. LILLY ZHENG, M.D., PATRICK C. WALSH, M.D., JAMES E. MONTIE, M.D., JIANFENG XU, M.D., DR.P.H., JOHN D. CARPTEN, PH.D., WILLIAM B. ISAACS, PH.D., AND KATHLEEN A. COONEY, M.D. N ENGL J MED 2012; 366:141-149 JAN, 2012. 5. WHOLE GENOME SEQUENCING OF A RARE NASAL TRACT CANCER CALLED OLFACTORY NEUROBLASTOMA IDENTIFIED GENETIC MUTATIONS THAT COULD BE FUTURE TARGETS OF ADVANCED PRECISION-MEDICINE DRUG DEVELOPMENT, ACCORDING TO A STUDY PUBLISHED IN THE JOURNAL PLOS ONE. A COMPARISON OF A PATIENT'S NORMAL AND TUMOR DNA IDENTIFIED SIGNIFICANT GENE MUTATIONS, SELECTED BASED ON CLINICAL RELEVANCE OF THE TARGET GENES AND THEIR ASSOCIATION WITH THE PROGRESSION OF CANCER. CITATION: WEISS GJ, LIANG WS, IZATT T, ARORA S, CHERNI I, ET AL. (2012). "PAIRED TUMOR AND NORMAL WHOLE GENOME SEQUENCING OF METASTATIC OLFACTORY NEUROBLASTOMA." PLOS ONE 7(5): E37029. DOI:10.1371/JOURNAL.PONE.0037029. 6. IN A SCAN OF 1,233 PROSTATE CANCER FAMILIES, RESEARCHERS IDENTIFIED SUGGESTIVE EVIDENCE FOR LINKAGE IN CHROMOSOMES 4 AND 8, WITH ADDITIONAL REGIONS IMPLICATED IN SUBSETS OF FAMILIES DEFINED BY AGE AT DIAGNOSIS, DISEASE AGGRESSIVENESS, OR NUMBER OF AFFECTED MEMBERS. THESE RESULTS, PUBLISHED IN THE MARCH ISSUE OF THE JOURNAL PROSTATE, WILL BE USEFUL IN PRIORITIZING FUTURE SUSCEPTIBILITY GENE DISCOVERY EFFORTS IN THIS COMMON CANCER. CITATION: "CHROMOSOMES 4 AND 8 IMPLICATED IN A GENOME WIDE SNP LINKAGE SCAN OF 762 PROSTATE CANCER FAMILIES COLLECTED BY THE ICPCG." JOHN CARPTEN AND 37 COLLABORATORS, INCLUDING THE INTERNATIONAL CONSORTIUM FOR PROSTATE CANCER GENETICS. PROSTATE. 2012 MAR;72(4):410-26. DOI: 10.1002/PROS.21443. 7. IN A STUDY OF HOW BRAIN CANCER CELLS SPREAD, RESEARCHERS FOUND THAT THE CDC42 GENES AND THE PROTEINS ECT2 AND TRIO HAVE AN EFFECT ON HOW THE TWEAK-FN14 SIGNALING PATHWAY STIMULATES THE MIGRATION AND INVASION OF GLIOMA CELLS. THESE FINDINGS, PUBLISHED IN MAY IN THE JOURNAL MOLECULAR CANCER RESEARCH, PROVIDE A POTENTIAL INNOVATIVE DRUG TARGET FOR GLIOMA THERAPY. CITATION: "CDC42 AND THE GUANINE NUCLEOTIDE EXCHANGE FACTORS ECT2 AND TRIO MEDIATE FN14-RAC1-INDUCED MIGRATION AND INVASION OF GLIOBLASTOMA CELLS." SHANNON FORTIN, NHAN TRAN AND 8 OTHER COLLABORATORS. MOL CANCER RES. 2012 JUL;10(7):958-68. EPUB 2012 MAY 9. 8. FOLLOWING UP ON A 2009 OUTBREAK OF ANTHRAX AMONG HEROIN USERS IN SCOTLAND, THIS STUDY USED WHOLE GENOME SEQUENCING TO DISCOVER THAT A NEW OUTBREAK OF ANTHRAX IN SCOTLAND, ENGLAND AND GERMANY WAS LINKED TO TURKEY, AND NOT TO PREVIOUS ISOLATES FROM SCOTLAND OR AFGHANISTAN. CITATION: PRICE EP, SEYMOUR ML, SAROVICH DS, LATHAM J, WOLKEN SR, MASON J, ET AL. "MOLECULAR EPIDEMIOLOGIC INVESTIGATION OF AN ANTHRAX OUTBREAK AMONG HEROIN USERS, EUROPE." EMERG INFECT DIS. 2012 AUG DOI: 10.3201/EID1808.111343. 9. WHOLE GENOME SEQUENCING WAS USED FOR THE FIRST TIME TO SIMULTANEOUSLY PROFILE THREE PATIENTS WITH PANCREATIC CANCER IN THIS TGEN-LED STUDY PUBLISHED IN OCTOBER BY PLOS ONE. THE ANALYSIS, ASSISTED BY SCOTTSDALE HEALTHCARE AND MAYO CLINIC, SHOWED THAT WGS "IS AN OBVIOUS AND POWERFUL METHOD FOR ADVANCING OUR UNDERSTANDING OF PANCREATIC CANCER." IN ALL THREE CASE STUDIES, THE REPORT FOUND MULTIPLE POTENTIAL THERAPEUTIC TARGETS, HIGHLIGHTING THE NEED TO STUDY THE FULL SPECTRUM OF THE GENOME AND RE-EMPHASIZING THE NEED TO DEVELOP MULTIPLE AVENUES OF THERAPEUTICS TO MATCH THE SPECIFIC MEDICAL CHALLENGES OF EACH PATIENT. CITATION: "GENOME-WIDE CHARACTERIZATION OF PANCREATIC ADENOCARCINOMA PATIENTS USING NEXT GENERATION SEQUENCING." LIANG WS, CRAIG DW, CARPTEN J, BORAD MJ, DEMEURE MJ, ET AL. (2012) GENOME-WIDE CHARACTERIZATION OF PANCREATIC ADENOCARCINOMA PATIENTS USING NEXT GENERATION SEQUENCING. PLOS ONE 7(10): E43192. DOI:10.1371/JOURNAL.PONE.0043192 10. IN ANOTHER EFFORT TO DISCOVER BETTER THERAPIES FOR PANCREATIC CANCER, THIS STUDY PUBLISHED IN 2012 IN THE JOURNAL OF CLINICAL ONCOLOGY SCANNED THE RECORDS OF MORE THAN 1,000 PATIENTS, RESULTING IN THE IDENTIFICATION OF NUMEROUS ACTIONABLE TARGETS FOR FURTHER RESEARCH. THE STUDY REITERATED THE IMPORTANCE OF KRAS MUTATIONS, SUGGESTED TOPO2 INHIBITORS FOR EXAMINATION, AND ENCOURAGED THE POSSIBLE EXPLORATION OF OTHER CELLULAR PATHWAYS, INCLUDING DNA REPAIR AND AMINO ACID TARGETS. THIS STUDY WAS SUPPORTED IN PART BY A STAND UP TO CANCER DREAM TEAM AWARD. CITATION: "ACTIONABLE TARGETS IN PANCREATIC CANCER DETECTED BY IMMUNOHISTOCHEMISTRY (IHC), MICROARRAY (MA) FLUORESCENT IN SITU HYBRIDIZATION (FISH), AND MUTATIONAL ANALYSIS." DANIEL D. VON HOFF, RAMESH K. RAMANATHAN, DOUGLAS B. EVANS, MICHAEL J. DEMEURE, TODD MANEY, BRIAN WRIGHT, ZORAN GATALICA, MATTHEW JEROME MCGINNISS; VIRGINIA G. PIPER CANCER CENTER AT SCOTTSDALE HEALTHCARE/TGEN, SCOTTSDALE, AZ; MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI; TRANSLATIONAL GENOMIC RESEARCH INSTITUTE, PHOENIX, AZ; CARIS LIFE SCIENCES, PHOENIX, AZ. J CLIN ONCOL 30, 2012 (SUPPL; ABSTR 4013).
CLINICAL RESEARCH / CLINICAL TRIALS   MEDICINE IS AT A CROSSROADS. GENOMIC AND OTHER -OMIC GENERATED INFORMATION CAN GREATLY INFORM THERAPEUTIC DECISIONS BY PROVIDING A GREATER UNDERSTANDING OF THE UNDERLYING BIOLOGICAL DEFECTS ASSOCIATED WITH A PARTICULAR DISEASE OR DISORDER. SINCE DAY ONE AT TGEN, OUR GOAL HAS ALWAYS BEEN TO CHAMPION GENOMIC-BASED MEDICINE BY USING AN INDIVIDUAL'S GENETIC PROFILE TO GUIDE CLINICAL DECISIONS ABOUT PREVENTING, DIAGNOSING, AND TREATING HIS OR HER DISEASE. MATCHING THE RIGHT PATIENT WITH THE RIGHT THERAPY APPROPRIATE TO THE UNDERLYING GENETICS OF THEIR SPECIFIC DISEASE WILL MEAN THAT A HIGHER PROPORTION OF PATIENTS WILL BENEFIT. THERE WILL BE MORE DURABLE RESPONSES AND LONGER SURVIVAL TIMES. THERE WILL BE LESS UNNECESSARY TOXICITY, EXPENSE, AND TIME WASTED ON INEFFECTIVE THERAPIES. ESTABLISHED IN 2006, THE VIRGINIA G. PIPER CANCER CENTER (VGPCC) CLINICAL TRIALS PROGRAM AT SCOTTSDALE HEALTHCARE, A STRATEGIC ALLIANCE WITH SCOTTSDALE HEALTHCARE (SHC), PROVIDES A DIRECT CLINICAL RESEARCH SITE FOR TGEN. DR. DANIEL VON HOFF, TGEN'S PHYSICIAN-IN-CHIEF, SERVES AS CHIEF SCIENTIFIC OFFICER. PROGRAM CLINICIANS FOCUS ON CLINICAL TRIALS WITH TARGETED AGENTS AND GENOMICS-BASED INDIVIDUALIZED THERAPY. THE VGPCC CLINICAL TRIALS PROGRAM, WITH AN INITIAL FOCUS ON CANCER, ALLOWS THE UNIQUE OPPORTUNITY FOR TGEN TO TRANSITION ITS LABORATORY-BASED RESEARCH TO PATIENT CARE CENTERED ON INDIVIDUALIZED THERAPY. PROGRAM STAFF CURRENTLY WORKING ON THE PHASE I CLINICAL TRIALS PATIENT PARTICIPATION IN CLINICAL TRIALS INCLUDE: - OVER 300 VISITS PER MONTH - NEARLY 40 NEW PATIENTS PER MONTH - OVER 400 PATIENT SAMPLES COLLECTED PER MONTH. 2012 HIGHLIGHTS FEBRUARY 1, 2012 - A NEW SKIN CANCER DRUG TESTED FOR THE FIRST TIME IN THE WORLD FIVE YEARS EARLIER BY TGEN AND SCOTTSDALE HEALTHCARE RECEIVES EXPEDITED APPROVAL BY THE U.S. FOOD AND DRUG ADMINISTRATION, A REMARKABLE ACCOMPLISHMENT IN NEW DRUG DEVELOPMENT. APRIL 3, 2012 - RESULTS OF THE FEASIBILITY OF SELECTING TREATMENT BASED ON INDIVIDUAL MOLECULAR CHARACTERISTICS WAS DEMONSTRATED IN A FIRST-OF-ITS KIND PANCREATIC CANCER CLINICAL TRIAL WAS REPORTED BY TGEN / SCOTTSDALE HEALTHCARE AT AACR ANNUAL MEETING. JUNE 13, 2012 - TGEN / SCOTTSDALE HEALTHCARE STUDY AN INVESTIGATIONAL DRUG THAT ACTS LIKE A TROJAN HORSE TO DELIVER CANCER KILLING AGENTS FOR PANCREATIC. THE PHASE 2 CLINICAL TRIAL TESTS THE EFFECTIVENESS AND SAFETY OF INNO-206 IN PATIENTS WITH ADVANCED PANCREATIC DUCTUAL ADENOCARCINOMAS (PDA) WHO HAVE NOT RESPONDED TO PRIOR STANDARD TREATMENT. AUGUST 29, 2012 - A PHASE I/II, MULTI-CENTER TRIAL DESIGNED TO TEST THE SAFETY AND PRELIMINARY EFFICACY OF A FIRST IN CLASS CANCER TREATMENT OPENS AT TGEN / SCOTTSDALE HEALTHCARE CLINIC. PR610 IS DESIGNED TO ACTIVATE IN TISSUES WITH LOW LEVELS OF OXYGEN, WHICH IS CHARACTERISTIC OF MANY CANCERS. GRANT SUPPORT GRANT FUNDING IS OFTEN THE LIFEBLOOD OF RESEARCH. IN 2012, TGEN INVESTIGATORS SUBMITTED 145 GRANTS TOTALING $115M. TGEN WAS AWARDED 9 GRANTS, TOTALING $1.4M, WITH AN ADDITIONAL 71 GRANTS PENDING AND IN REVIEWS TOTALING $70M. ADDITIONALLY, TGEN RECEIVED $12.8M FROM 2010 AND 2011 PENDING GRANTS, BRINGING THE AWARDED TOTAL FOR 2012 TO $14.2M. TGEN'S SUCCESS RATE CURRENTLY RESTS AT 23 PERCENT OF TOTAL GRANTS SUBMITTED, PLACING THE INSTITUTE NEARLY 3 PERCENT HIGHER THAN THE NATIONAL AVERAGE (NIH OVERALL SUCCESS RATE). 1. THREE-YEAR GRANT FROM STAND UP TO CANCER (SU2C) AND MELANOMA RESEARCH ASSOCIATION TOTALING $5,981,538 TO DR. JEFFREY TRENT FOR A PERSONALIZED MEDICINE STUDY OF PATIENTS WITH BRAF WILD-TYPE MELANOMA. 2. THREE-YEAR GRANT FROM THE MUSCULAR DYSTROPHY ASSOCIATION TOTALING $208,486 TO DR. LISA BAUMBACH-REARDON TO STUDY MUSCULAR DYSTROPHY. 3. UNDER SUBCONTRACT, A FIVE-YEAR GRANT FROM THE NATIONAL INSTITUTES OF HEALTH (NIH) TOTALING $124,992 TO DR. MATTHEW HUENTELMAN TO STUDY ALZHEIMER'S DISEASE AND SUPPORT THE ARIZONA ALZHEIMER'S DISEASE CORE CENTER (ADCC). 4. FIVE-YEAR GRANT FROM THE NATIONAL INSTITUTES OF HEALTH TOTALING $2.5 MILLION TO DR. MICHAEL BERENS TO SEARCH FOR NEW DRUG TARGETS IN GLIOBLASTOMA AND OTHER CANCERS THAT COULD BE SHARED WITH THE CANCER TARGET DISCOVERY AND DEVELOPMENT NETWORK. 5. THREE-YEAR GRANT UNDER SUBCONTRACT WITH THE UNIVERSITY OF MICHIGAN FROM SUSAN G. KOMEN FOR THE CURE TOTALING $533,180 TO DR. JEFFREY TRENT TARGETING STEM CELLS IN TRIPLE-NEGATIVE BREAST CANCER IN DIFFERENT RACIAL POPULATIONS, INCLUDING CLINICAL TRIALS. 6. TWO-YEAR GRANT FROM NATIONAL INSTITUTES OF HEALTH TOTALING $531,755 TO DR. PAUL KEIM TO STUDY CRYPTOCOCCUS GATTII BY SEQUENCING 200 GENOMES OF THIS TYPE OF FUNGUS, INCLUDING A PARTICULARLY VIRULENT AMERICAN STRAIN DESIGNATED AS VGIIC. 7. TWO-YEAR SUBCONTRACT GRANT (MAYO CLINIC IS PRIME) FROM ACCELERATE BRAIN CANCER CURE INC. TOTALING $262,480 TO DR. JOHN CARPTEN TO SHOW HOW WHOLE GENOME SEQUENCING CAN BE USED TO IDENTIFY CLINICALLY ACTIONABLE VULNERABILITIES IN GLIOBLASTOMA MULTIFORME (GBM) PATIENTS. 8. FOUR-YEAR GRANT FROM THE DEPARTMENT OF DEFENSE TOTALING $938,715 TO DR. PAUL KEIM TO CONDUCT GENOMIC PROFILES OF THE VARIOUS NEAR-NEIGHBOR FORMS OF THE PATHOGEN B. PSEUDOMALLEI, A BIOLOGICAL WARFARE AGENT. NAU IS PRIME ON THIS SUBCONTRACT. 9. UNDER SUBCONTRACT FROM THE UNIVERSITY OF GEORGIA, A FIVE-YEAR GRANT FROM THE NATIONAL CANCER INSTITUTE (NIH) TOTALING $663,574 TO DR. DANIEL VON HOFF TO IDENTIFY POTENTIAL GLYCOMARKERS FOR PANCREATIC AND BREAST CANCER IN AN EFFORT TOWARD EARLY CANCER DETECTION. 10. UNDER SUBCONTRACT FROM NAU, A FIVE-YEAR GRANT FROM THE NATIONAL SCIENCE FOUNDATION TOTALING $499,759 TO DR. LANCE PRICE TO STUDY MICROBIAL BIODIVERSITY IN RELATION TO SOIL CARBON CYCLES. ENTERPRISE EFFORTS, COLLABORATION AND JOB CREATION TGEN'S OFFICES OF BUSINESS DEVELOPMENT AND TECHNOLOGY TRANSFER WORK TO DEVELOP AN APPROPRIATE ADMINISTRATIVE STRUCTURE TO HANDLE COMMERCIALIZATION OF ITS INTELLECTUAL PROPERTY, AS WELL AS DEVELOPING EFFECTIVE WAYS TO PARTNER WITH THE COMMERCIAL SECTOR. THE TECHNOLOGY TRANSFER OFFICE (TTO) FACILITATES AND ACCELERATES THE COMMERCIALIZATION OF TGEN'S SCIENTIFIC DISCOVERIES FOR THE BENEFIT OF HUMAN HEALTH BY: A. IDENTIFYING, PATENTING AND LICENSING NEW TECHNOLOGY; B. FACILITATING ACCESS AND EXCHANGE OF RESEARCH MATERIALS, TECHNOLOGIES, AND DATA VIA MATERIAL TRANSFER AGREEMENTS (MTAS) OR CONFIDENTIAL DISCLOSURE AGREEMENTS (CDAS); C. NEGOTIATING COLLABORATIVE RESEARCH AGREEMENTS; AND D. ASSISTING IN THE FORMATION OF START-UP COMPANIES WHEN APPROPRIATE.
INVENTION DISCLOSURES   TGEN SCIENTISTS WORK WITH THE OFFICE OF TECHNOLOGY TRANSFER (OTT) TO FILE INVENTION DISCLOSURES AS THE FIRST STEP TOWARD A POSSIBLE PATENT APPLICATION OR OTHER APPROPRIATE FORM OF INTELLECTUAL PROPERTY PROTECTION. TGEN FILED 24 INVENTION DISCLOSURES IN 2012 BASED ON DISCOVERIES STEMMING FROM TGEN-LED RESEARCH, AND 16 PROVISIONAL PATENT APPLICATIONS. SPIN OFFS TGEN FORMED TWO SINGLE MEMBER LLCS (TRANSLATIONAL SYSTEMS LLC AND ASHION ANALYTICS LLC) IN 2012. CONTRACTS AND COLLABORATIONS TGEN SIGNED A TOTAL OF 434 CONTRACTS IN 2012, BROKEN DOWN AS FOLLOWS: A. 104 CONFIDENTIAL DISCLOSURE AGREEMENTS (CDA) B. 64 MATERIAL TRANSFER AGREEMENTS (MTA) C. 45 RESEARCH COLLABORATIONS (MANY WITH LOCAL AND STATE AFFILIATIONS), INCLUDING AGREEMENTS THAT FURTHER RESEARCH INTO A HOST OF DISEASES, INCLUDING BRAIN CANCER, MELANOMA, ALZHEIMER'S AND AUTISM. D. 29 CONSULTING AGREEMENTS E. 80 PROFESSIONAL SERVICES AGREEMENTS F. 4 COMMERCIALIZATION LICENSES G. 108 AGREEMENTS COVERING MISCELLANEOUS ACTIVITIES 1. MAYO CLINIC - "A PILOT STUDY EXAMINING THE UTILITY OF WHOLE GENOME TUMOR SEQUENCING (WGS) AND WHOLE GENOME EXPRESSION PROFILE TO FIND POTENTIAL TARGETS FOR THERAPY IN PATIENTS WITH ADVANCED CANCER" (DRS. CARPTEN, VON HOFF, RAMANATHAN & STEWART, BORAD, FONSECA, RAMANATHAN, VON HOFF) 2. MAYO CLINIC - CONTINUATION OF THE INTEGRATED CANCER GENOME RESEARCH FOCUSED ON NEXT-GENERATION SEQUENCING AND BIOINFORMATIC ANALYSIS. 3. CENTERS FOR DISEASE CONTROL RESEARCH (CDC) COLLABORATION AGREEMENT - PROJECTS INVOLVING ANTIBIOTIC-RESISTANT AND HEALTHCARE-ASSOCIATED BACTERIAL PATHOGENS (DRS. ENGELTHALER, LIMBAGO & MACCANNELL) 4. PHOENIX CHILDREN'S HOSPITAL RESEARCH PLAN 01 - PROFESSIONAL SERVICES PROVIDED TO TGEN BY DR. RATAN BHARDWAJ (DRS. BERENS & CRAIG) 5. SCOTTSDALE HEALTHCARE 2ND AMENDMENT TO RESEARCH PLAN 02 - EXTENDS TERM THROUGH 3/25/13 (DRS. BUSSEY & DEMEURE) 6. UNIVERSITY OF ARIZONA RESEARCH PLAN - "ASSESSING PRIMARY CILIA AND CENTROSOMES IN BASAL CELL CARCINOMA" (DRS. WEISS & MCDERMOTT) 7. MARICOPA INTEGRATED HEALTH SYSTEM (MIHS) AMENDMENT ONE TO RESEARCH COLLABORATION AGREEMENT - EXTENDS TERM THROUGH JUNE 20, 2015 8. PHOENIX CHILDREN'S HOSPITAL AMENDMENT ONE TO RESEARCH PLAN - "PROFESSIONAL SERVICES AGREEMENT FOR DR. RATAN BHARDWAJ" - REVISES PLANNING SUMMARY AND FINANCIAL PLAN (DRS. BHARDWAJ, CRAIG & BERENS) 9. VETERINARY NEUROLOGICAL CENTER RESEARCH COLLABORATION AGREEMENT & RESEARCH PLAN 01 - "CANINE BRAIN TUMOR DENDRITIC CELL VACCINE" (DRS. DECKER, CRAIG & BHARDWAJ) 10. TEXAS ENGINEERING EXPERIMENT STATION AMENDMENT THREE TO MEMORANDUM OF UNDERSTANDING (DR. DOUGHERTY) - 11. HILL'S PET NUTRITION RESEARCH - "EVALUATING THE IMPACTS OF PREBIOTICS AND PROBIOTICS ON THE FELINE GI MICROBIOME" (DR. PRICE) 12. MAYO CLINIC STATEMENT OF WORK 11 - "KNOWLEDGE MINING DATA FROM HT-RNAI SCREEN ON ANAPLASTIC THYROID CANCER CELLS" (DRS. COPLAND & KIEFER) 13. ILLUMINA AMENDMENT ONE TO STATEMENT OF WORK 3 - EXTENDS COLLABORATION PLANNING PERIOD THROUGH SEPTEMBER 17, 2012 14. SPECTRUM HEALTH HOSPITALS RESEARCH COLLABORATION AGREEMENT AND RESEARCH PLAN 01 - "UNDERSTANDING THE SHIFTS IN INTESTINAL GUT FLORA IN CHEMOTHERAPY PATIENTS AT RISK FOR INTESTINAL MUCOSITIS (DRS. PRICE & KURT) 15. MAYO CLINIC FIRST AMENDMENT TO RESEARCH PLAN (SELINSKY) - FOR PROJECT LUNG, EXTENDS TERM THROUGH DECEMBER 31, 2012 JOB CREATION SEVEN NEW FULL-TIME EQUIVALENT POSITIONS WERE CREATED IN 2012 WITH SALARIES AND BENEFITS TOTALING $557,329. SALARIES FOR TEMPORARY POSITIONS (THOSE POSITIONS CREATED FOR A FINITE PERIOD OF TIME) TOTALED $106,745 AND STUDENT SALARIES WERE JUST OVER $332,469, BRINGING THE OVERALL TOTAL TO $996,543. THIS BROUGHT THE TOTAL FOR TGEN STAFF TO 257 IN 2012, OF WHICH 78 PERCENT HOLD A COLLEGE DEGREE AND 46 PERCENT HOLD AN ADVANCED DEGREE. 2012 POSITIONS FILLED (NEW AND REPLACEMENTS) INCLUDED: ADMINISTRATIVE ASSISTANT ASSISTANT DEVELOPMENT DIRECTOR ASSOCIATE BIOINFORMATICIAN BUSINESS ANALYST ENTERPRISE APPLICATIONS DIRECTOR LAB MANAGER POST-DOC FELLOW PROJECT ACCOUNTING DIRECTOR PURCHASING AGENT QUALITY ASSURANCE SPECIALIST RESEARCH ASSOCIATE RESEARCH ASSOCIATE II RESEARCH TECHNICIAN SOFTWARE ENGINEER SR. HIGH-PERFORMANCE COMPUTING ENGINEER STAFF SCIENTIST EDUCATION AND PUBLIC OUTREACH TGEN SCIENCE EDUCATION AND COMMUNITY OUTREACH IS GEARED TOWARD THE DEVELOPMENT OF A TALENTED BIOSCIENCE WORKFORCE IN ARIZONA, AND INCREASED PUBLIC FLUENCY IN GENOMIC SCIENCE AND TRANSLATIONAL MEDICINE. 2012 HIGHLIGHTS INCLUDE: INTERNSHIPS 2012 SAW 45 ARIZONA STUDENTS PARTICIPATE IN TGEN'S FLAGSHIP, PAID SUMMER INTERNSHIP PROGRAM, HELIOS SCHOLARS AT TGEN. COHORT DEMOGRAPHICS: 82 PERCENT ATTENDED PUBLIC ACADEMIC INSTITUTIONS; 27 PERCENT SELF-IDENTIFIED AS RACES/ETHNICITIES UNDERREPRESENTED IN THE BIOSCIENCES; 51 PERCENT ARE FEMALE; 13 PERCENT WERE IN HIGH SCHOOL, 82 PERCENT IN COLLEGE AND 5 PERCENT IN GRADUATE OR MEDICAL SCHOOL. TGEN BEGAN TO RE-ENGAGE THE NEARLY 250 HELIOS SCHOLARS ALUMNI BY DEVELOPING A TRACKING DATABASE AND HOSTING THE FIRST ALUMNI NETWORKING RECEPTION. TGEN INTENDS TO MAINTAIN RELATIONSHIPS WITH ALUMNI WHO CAN MENTOR CURRENT INTERNS AND ACT AS AMBASSADORS FOR ARIZONA BIOSCIENCES IN THEIR SOCIAL AND PROFESSIONAL NETWORKS. NEW IN 2012 IS THE IVY NEUROLOGICAL SCIENCES INTERNSHIP PROGRAM, A SUMMER AND FALL PAID INTERNSHIP PROGRAM SUPPORTING THREE HIGH SCHOOL STUDENTS AND TWO UNDERGRADUATES ANNUALLY FOR NEUROLOGICAL DISEASE RESEARCH AND A CLINICAL TRAINING MODULE. TGEN PILOTED A PARTNERSHIP WITH DUKE UNIVERSITY TO BRING TWO DUKE UNDERGRADUATES INTERESTED IN BIOINFORMATICS AND GENOMICS TO STUDY AT TGEN FOR A 10-WEEK INTERNSHIP. THIS BROADENED AWARENESS OF TGEN NATIONALLY AND IT IS HOPED THAT STUDENT SHARING WILL SET THE STAGE FOR FUTURE FACULTY COLLABORATIONS. OUTSIDE OF THESE PROGRAMS, TGEN HOSTED APPROXIMATELY 15 SUMMER INTERNS, AND NEARLY 50 NON-PROGRAM ACADEMIC YEAR INTERNS THROUGHOUT ALL TGEN RESEARCH DIVISIONS INCLUDING LABORATORY AND CLINICAL RESEARCH, RESEARCH ADMINISTRATION, AND MATHEMATICS AND COMPUTATIONAL BIOLOGY RESEARCH. EDUCATIONAL TOURS TGEN HOSTED OVER 50 PUBLIC TOURS (500+ ATTENDEES) FOR STUDENTS, TEACHERS, COMMUNITY ORGANIZATIONS AND THE GENERAL PUBLIC. TGEN ALSO HOSTED AN IN-DEPTH PUBLIC TOUR, "DNA BY MOONLIGHT," WITH NEARLY 50 ATTENDEES IN SUPPORT OF THE INAUGURAL YEAR OF THE ARIZONA SCITECH FESTIVAL. IN MARCH 2012, TGEN SUPPORTED THREE LOCAL HIGH SCHOOL STUDENTS FROM THE BE A LEADER FOUNDATION FOR THE ANNUAL SHADOW A PROFESSIONAL DAY.
COMMUNITY OUTREACH   TGEN FACULTY AND STAFF PARTICIPATED IN LOCAL, REGIONAL AND STATEWIDE SCIENCE FAIRS, AND SHARED INSIGHT AND RESEARCH INFORMATION AT COMMUNITY EVENTS, CAREER DAYS, EXPOS, AND EXPERT PANELS AT MIDDLE AND HIGH SCHOOLS, COMMUNITY COLLEGES, UNIVERSITIES, ETC. TGEN IS REPRESENTED ON THE LOCAL ARRANGEMENTS COMMITTEE, AND RECRUITS JUDGES AND VOLUNTEERS, FOR THE UPCOMING THREE-YEAR PHOENIX ROTATION OF THE INTEL INTERNATIONAL SCIENCE AND ENGINEERING FAIR. TGEN STAFF SERVED ON LOCAL ADVISORY COMMITTEES AND BOARDS IN SUPPORT OF SCIENCE EDUCATION SUCH AS THE ARIZONA SCIENCE CENTER PATHWAYS PROGRAM DESIGN TEAM, THE CHANDLER-GILBERT COMMUNITY COLLEGE BIOMEDICAL RESEARCH TECHNOLOGY PROGRAM ADVISORY BOARD, THE FLINN SCHOLARS PROGRAM REVIEW TEAM, AND SEVERAL OTHERS. MEDIA/ON-LINE TGEN REMAINS ACTIVE IN PURSUING POSITIVE EARNED MEDIA EXPOSURE FOR THE INSTITUTE'S RESEARCH AND PHILANTHROPIC ACTIVITIES. MEDIA EXPOSURE RAISES AWARENESS AND BRINGS ADDED CREDIBILITY TO THE INSTITUTE AND THE STATE. IN TOTAL, TGEN RECEIVED GREATER THAN 1000 MEDIA MENTIONS IN 2012 IN VARIOUS TRADE AND PUBLIC MEDIA: LOCALLY, NATIONALLY AND INTERNATIONALLY. WHILE CITING TGEN SPECIFICALLY, THESE ARTICLES AND NEWS BRIEFS HELP BUILD A GREATER PRESENCE FOR THE CONTINUOUSLY EXPANDING BIOMEDICAL SCIENCE INITIATIVES OCCURRING IN ARIZONA. MEDIA OUTLETS INCLUDE: ABC NEWS, ARIZONA DAILY SUN, THE ARIZONA REPUBLIC, BLOOMBERG NEWS, THE BOSTON HERALD, CHICAGO TRIBUNE, CNN, DOW JONES, FLAGSTAFF TODAY, FORBES, THE INDEPENDENT (LONDON), KAET (CHANNEL 8), KNAU (FLAGSTAFF), KPNX (CHANNEL 12), THE LOS ANGELES TIMES, NEW YORK TIMES, NATIONAL PUBLIC RADIO, PHOENIX BUSINESS JOURNAL, PHOENIX MAGAZINE, USA TODAY, U.S. NEWS & WORLD REPORT, THE WASHINGTON POST, WIRED. A NEW LOGO AS TGEN ENTERS ITS SECOND DECADE, WE DO SO WITH A NEW LOGO AND WEBSITE THAT MORE SUCCINCTLY REFLECTS TGEN'S RESEARCH ENVIRONMENT AND MISSION AND THE RAPIDLY CHANGING TECHNOLOGIES THAT HAVE ACCELERATED OUR PACE OF DISCOVERY OVER THE PAST DECADE. THE NEW LOOK REFLECTS TGEN'S CONTINUED FOCUS ON THE PATIENT, PARTICULARLY IN THE AREAS OF CANCER, NEUROLOGY AND RARE CHILDHOOD DISORDERS. THESE CHANGES HAVE ALTERED THE PUBLIC VIEW OF HOW GENOMICS CAN POSITIVELY IMPACT SOCIETY IN TERMS OF MEDICAL CARE AND SO MANY ADDITIONAL FACETS OF LIFE. TGEN HAS ALWAYS BEEN FORWARD THINKING IN TERMS OF OUR RESEARCH AND ABILITY TO IMPACT PATIENT CARE, AND OUR NEW LOGO IS A FIRST STEP IN COMMUNICATING TO THE VARIOUS COMMUNITIES WITH INTEREST IN TGEN, THE VALUES THAT GUIDE OUR MISSION OF SETTING A NEW STANDARD OF CARE THROUGH THE EVOLUTION OF GENOMICS-BASED TECHNOLOGIES AND MEDICINE. THE NEW LOGO SHOWCASES THE INNOVATIVE SPIRIT OF TGEN, WHILE PAYING HOMAGE TO THE ORIGINAL LOOK BY INCORPORATING FORMS THAT COMPRISE THE ABSTRACT DEPICTION OF THE DOUBLE HELIX. THE CLEAN AND CONTEMPORARY (YET CLASSIC) DESIGN ILLUSTRATES THE ADVANCEMENT OF THE HEALTH AND SCIENCE FIELDS. THE INTERTWINING ELEMENTS EXEMPLIFY HOW HEALTH AND BIOLOGY WORK TOGETHER IN OUR MISSION TO TREAT AND CURE A VARIETY OF GENETIC DISEASES AND DISORDERS. REDEFINED ON-LINE PRESENCE WE'VE ALSO REDEFINED OUR ONLINE PRESENCE WITH A REDEVELOPED WEBSITE, THROUGH WHICH OUR VARIED STAKEHOLDERS CAN STAY UP-TO-DATE ON THE LATEST RESEARCH FINDINGS, PATIENT ADVANCES, PUBLIC EVENTS AND INITIATIVES. THE NEW WEBSITE MERGES THE TGEN AND TGEN FOUNDATION WEBSITES INTO ONE, WHICH MAKES IT EASIER TO LEARN ABOUT AND SUPPORT THE MISSION OF TGEN. OUR NEW IDENTITY RETAINS THE QUALITIES OF OUR BRAND PROMISE BUT REFLECTS OUR EVOLUTION OVER THE PAST DECADE IN BECOMING LEADERS IN THE AREA OF PERSONALIZED MEDICINE. THE NEW TGEN WEBSITE ALSO INCORPORATES THE USE OF RESPONSIVE DESIGN, AN INNOVATIVE LAYOUT DESIGN THAT ALLOWS THE WEBSITE TO BE PROPERLY RENDERED ON ALL DEVICE TYPES, SO THAT VISITORS TO THE SITE ARE ENSURED A POSITIVE BROWSING EXPERIENCE FROM BOTH AN AESTHETIC AS WELL AS A NAVIGATIONAL PERSPECTIVE.
CONSOLIDATED AUDITED FINANCIAL STATEMENTS FORM 990, PART IV, LINE 12B CONSOLIDATED AUDITED FINANCIAL STATEMENTS WERE ISSUED FOR THE 13-MONTH PERIOD ENDING DECEMBER 31, 2012. THE TAX YEAR BEING REPORTED FOR THIS FORM 990 IS FOR THE YEAR ENDED NOVEMBER 30, 2012. BUSINESS AND FAMILY RELATIONSHIPS FORM 990, PART VI, LINE 2 DANIEL VON HOFF AND EDWARD SUH HAVE A BUSINESS RELATIONSHIP. JEFFREY TRENT, DANIEL VON HOFF AND EDWARD SUH HAVE A BUSINESS RELATIONSHIP. ROBERT BULLA AND WILLIAM POST HAVE A BUSINESS RELATIONSHIP.
DESCRIPTION OF SIGNIFICANT CHANGES TO ORGANIZING OR ENABLING DOCUMENT FORM 990, PART VI, LINE 4 THE BYLAWS WERE AMENDED EFFECTIVE MARCH 12, 2012 TO REFLECT THE TERMINATION OF THE AFFILIATION AGREEMENT WITH VAN ANDEL RESEARCH INSTITUTE (VARI) WHEREBY VARI IS NO LONGER THE SOLE MEMBER OF TGEN AND TGEN CONVERTED FROM A MEMBER-BASED TO A DIRECTOR-BASED ARIZONA NONPROFIT CORPORATION. GOVERNANCE STRUCTURE FORM 990, PART VI, LINES 6, 7A & 7B LINE 6 THROUGH MARCH 12, 2012 THE SOLE MEMBER OF TGEN WAS VAN ANDEL RESEARCH INSTITUTE, A MICHIGAN CHARITABLE TRUST. EFFECTIVE MARCH 12, 2012, TGEN AND VARI AGREED TO TERMINATE THEIR AFFILIATION AGREEMENT, AND TGEN CONVERTED FROM A MEMBER-BASED, ARIZONA NONPROFIT CORPORATION TO A DIRECTOR-BASED, ARIZONA NONPROFIT CORPORATION, WHEREBY VARI IS NO LONGER THE SOLE MEMBER OF TGEN. LINE 7A VAN ANDEL RESEARCH INSTITUTE, AS THE SOLE MEMBER OF TGEN THROUGH 3/12/12, APPOINTED ELECTED DIRECTORS TO TGEN'S BOARD OF DIRECTORS FROM A LIST OF INDIVIDUALS PRESENTED BY THE NOMINATING COMMITTEE. EFFECTIVE 3/12/12 THE BOARD OF DIRECTORS OF TGEN HAS THE AUTHORITY TO ELECT AND APPOINT DIRECTORS AS NOMINATED BY THE BOARD OF GOVERNANCE AND EXECUTIVE COMPENSATION COMMITTEE. LINE 7B VAN ANDEL RESEARCH INSTITUTE, AS THE SOLE MEMBER OF TGEN THROUGH 3/12/12, RETAINED CERTAIN APPROVAL RIGHTS AS OUTLINED IN THE BYLAWS. EFFECTIVE 3/12/12, ALL GOVERNANCE DECISIONS ARE MADE BY THE BOARD OF DIRECTORS OF TGEN.
PROCESS USED BY MANAGEMENT AND/OR GOVERNING BODY TO REVIEW 990 FORM 990, PART VI, LINE 11 THE FORM 990 IS PREPARED BY AN OUTSIDE ACCOUNTING FIRM BASED ON INFORMATION PROVIDED BY THE FINANCE DEPARTMENT. THE 990 IS THEN REVIEWED BY THE FINANCE DEPARTMENT AND OTHER MEMBERS OF MANAGEMENT. THE FORM 990 IS POSTED ON THE BOARD WEBSITE PRIOR TO FILING WITH THE IRS.
PROCESS USED TO MONITOR TRANSACTIONS FOR CONFLICTS OF INTEREST FORM 990, PART VI, LINE 12C TGEN ISSUES A CONFLICT OF INTEREST QUESTIONNAIRE ON AN ANNUAL BASIS TO ALL DIRECTOR LEVEL POSITIONS AND ABOVE IN ADDITION TO ANY KEY EMPLOYEES DESIGNATED BY THE CHIEF OPERATING OFFICER. THE QUESTIONNAIRES ARE REVIEWED BY THE CHIEF FINANCIAL OFFICER, AND THOSE EMPLOYEES WITH CONFLICTS ARE SENT FOR FURTHER REVIEW TO CHIEF OPERATING OFFICER TO ENSURE A PLAN IS SET FORTH. UPDATES TO THE LIST ARE HANDLED ON AN AS NEEDED BASIS BASED ON CONTRACT REVIEWS AND EMPLOYEE INFORMATION.
PROCESS USED TO DETERMINE COMPENSATION FORM 990, PART VI, LINES 15A AND 15B TGEN'S GOVERNANCE AND EXECUTIVE COMPENSATION COMMITTEE WILL ACT IN AN "ADVICE AND CONSENT" CAPACITY REVIEWING THE RECOMMENDATIONS FOR THE PRESIDENT AND SCIENTIFIC DIRECTOR REGARDING THE COMPENSATION OF DISQUALIFIED PERSON AND FORWARDING FINAL RECOMMENDATIONS TO THE FULL BOARD FOR APPROVAL. DISQUALIFIED PERSONS (EXCEPT FOR THE PRESIDENT AND SCIENTIFIC DIRECTOR) WILL NOT BE PRESENT FOR, OR PARTICIPATE IN, COMMITTEE DELIBERATIONS CONCERNING THEIR COMPENSATION (OTHER THAN TO ANSWER QUESTIONS). THE PRESIDENT AND SCIENTIFIC DIRECTOR WILL PARTICIPATE IN THE DELIBERATIONS CONCERNING THE COMPENSATION OF DIRECT REPORTS. DURING THE DECISION MAKING PROCESS, THE COMMITTEE WILL ADHERE TO THE EXECUTIVE COMPENSATION PHILOSOPHY. THE COMMITTEE IS AUTHORIZED (AND PROVIDED WITH SUFFICIENT FUNDING) TO ANNUALLY ENGAGE OUTSIDE INDEPENDENT COMPENSATION AND LEGAL ADVISORS, WHEN DEEMED NECESSARY AND ADVISABLE. THE COMMITTEE WILL COMPLY WITH THE "REBUTTABLE PRESUMPTION OF REASONABLENESS" UNDER SECTION 4958 OF THE INTERNAL REVENUE CODE WHENEVER POSSIBLE. THE COMMITTEE WILL REVIEW AND UNDERSTAND THE INTERNAL REVENUE CODE PROVISIONS DEALING WITH "EXCESS BENEFIT TRANSACTIONS CONCERNING DISQUALIFIED PERSONS' COMPENSATION". WHEN DEVELOPING A COMPENSATION PHILOSOPHY TGEN KEPT IN MIND THE FOLLOWING FACTORS: THE TGEN MISSION AND STRATEGY THE TGEN CULTURE TRENDS IN COMPENSATION IN THE EXTERNAL ENVIRONMENT TRENDS IN RECRUITMENT OF NEW EMPLOYEES TRENDS IN ORGANIZATIONAL EMPLOYEE TURNOVER TGEN'S LIFE CYCLE STAGE
AVAILABILITY OF GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS TO THE GENERAL PUBLIC FORM 990, PART VI, LINE 19 THE ORGANIZATION'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE PROVIDED TO THE GENERAL PUBLIC UPON REQUEST.
BOARD OF GOVERNORS PART VII, SECTION A, LINE 1A TGEN HAS A BOARD OF GOVERNORS THAT IS COMPRISED OF CURRENT VOTING DIRECTORS AND SOME FORMER DIRECTORS THAT REMAIN AFFILIATED WITH TGEN IN AN ADVISORY ROLE. THE CURRENT GOVERNORS NOT LISTED AS DIRECTORS IN PART VII INCLUDE: BETSEY BAYLESS; RICHARD BOALS; SUSAN CLARK-JOHNSON; THE HONORABLE DIANE ENOS; JOHN HAEGER, PHD; THE HONORABLE JIM SLATTERY; DR. VICTOR TRASTEK; RAYMOND DUBOIS, MD, PHD; ANN WEAVER HART, PHD.
HOURS DEVOTED TO RELATED ORGANIZATION FORM 990, PART VII THE FOLLOWING INDIVIDUALS REPORTED IN PART VII ALSO DEVOTE TIME TO THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE FOUNDATION (FOUNDATION), A RELATED TAX-EXEMPT ORGANIZATION AS INDICATED: JEFFREY TRENT (39 HOURS PER WEEK TGEN; 1 HOUR PER WEEK FOUNDATION) TERESA BURLESON (39 HOURS PER WEEK TGEN; 1 HOUR PER WEEK FOUNDATION). DAVID VAN ANDEL AND JOHN KENNEDY ARE BOTH TGEN DIRECTORS WHO ARE COMPENSATED BY VARI, A RELATED TAX-EXEMPT ORGANIZATION; VAN ANDEL AS A CHAIRMAN/CEO AND KENNEDY AS A TRUSTEE. COMPENSATION AND HOURS INFORMATION WAS NOT AVAILABLE FOR DISCLOSURE ON THIS RETURN.
OTHER CHANGES IN NET ASSETS OR FUND BALANCES PART XI, LINE 5 UNREALIZED GAIN/LOSSES $658,933
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2011

Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" to Form 990, Part IV, line 33, 34, 35, 36, or 37.
MediumBulletAttach to Form 990. MediumBullet See separate instructions.

OMB No. 1545-0047
2011
Open to Public Inspection
Name of the organization
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
 
Employer identification number

75-3065445
Part I
Identification of Disregarded Entities (Complete if the organization answered "Yes" on Form 990, Part IV, line 33.)
(a)
Name, address, and EIN of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income
(e)
End-of-year assets


 		(f)
Direct controlling
entity







(1) TGEN ACCELERATOR MANAGEMENT LLC
445 NORTH 5TH STREET 600
PHOENIX,AZ85004
75-3065445 		GENOMICS AZ 0 0 NA
 
(2) THE CENTER FOR TRANSLATIONAL DRUG DEV
445 NORTH 5TH STREET 600
PHOENIX,AZ85004
43-2047329 		DRUG DEVEL. AZ 3,713,086 3,089,363 TGEN ACC MGT
 
(3) INT'L BIOSCIENCES COMMERCIALIZATION LLC
445 NORTH 5TH STREET 600
PHOENIX,AZ85004
27-2987735 		LICENSING AZ 0 0 TGEN ACC MGT
 
(4) ASHION ANALYTICS LLC
445 NORTH 5TH STREET 600
PHOENIX,AZ85004
45-4587602 		GENO ANALYSIS AZ 0 0 NA
 
(5) TRANSLATIONAL SYSTEMS LLC
445 NORTH 5TH STREET 600
PHOENIX,AZ85004
46-1309498 		ADV RESEARCH AZ 0 0 NA
 


Part II
Identification of Related Tax-Exempt Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.)
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section
(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled organization
Yes No
(1) TGEN RESEARCH INSTITUTE FOUNDATION

445 NORTH 5TH STREET 600

PHOENIX,AZ85004
33-1092191 		FUND RAISING AZ 501(C)(3) 7 TGEN
 
Yes
 
(2) VAN ANDEL RESEARCH INSTITUTE

333 BOSTWICK AVENUE STE 850

GRAND RAPIDS,MI49503
52-2000823 		MEDICAL RSRCH MI 501(C)(3) 4 NA
 
 
No










For Privacy Act and Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2011
Schedule R (Form 990) 2011
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.)
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V—UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No












Part IV
Identification of Related Organizations Taxable as a Corporation or Trust (Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.)
(a)
Name, address, and EIN of related organization



 		(b)
Primary activity



 		(c)
Legal domicile
(state or
foreign
country)
 		(d)
Direct controlling
entity


 		(e)
Type of entity
(C corp, S corp,
or trust)

 		(f)
Share of total income



 		(g)
Share of
end-of-year
assets

 		(h)
Percentage
ownership












Schedule R (Form 990) 2011
Schedule R (Form 990) 2011
Page 3
Part V
Transactions With Related Organizations (Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35, 35A, or 36.)
Note. Complete line 1 if any entity is listed in Parts II, III or IV.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest (ii) annuities (iii) royalties (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .
1a
 
No
b Gift, grant, or capital contribution to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1b
 
No
c Gift, grant, or capital contribution from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1c
Yes
 
d Loans or loan guarantees to or for related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1d
 
No
e Loans or loan guarantees by related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1e
 
No
f Sale of assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1f
 
No
g Purchase of assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1g
 
No
h Exchange of assets with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1h
 
No
i Lease of facilities, equipment, or other assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1i
 
No
j Lease of facilities, equipment, or other assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .
1j
 
No
k Performance of services or membership or fundraising solicitations for related organization(s) . . . . . . . . . . . . . . . . . . . .
1k
 
No
l Performance of services or membership or fundraising solicitations by related organization(s) . . . . . . . . . . . . . . . . . . . .
1l
Yes
 
m Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) . . . . . . . . . . . . . . . . . . . . .
1m
Yes
 
n Sharing of paid employees with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1n
Yes
 
o Reimbursement paid to related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1o
Yes
 
p Reimbursement paid by related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1p
 
No
q Other transfer of cash or property to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1q
 
No
r Other transfer of cash or property from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1r
 
No
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of other organization 		(b)
Transaction
type(a-r) 		(c)
Amount involved 		(d)
Method of determining amount involved
(1) THE TRANSLATIONAL GENOMICS RESEARCH INST FDN

 L 18,008,282 ACTUAL COST
(2) THE TRANSLATIONAL GENOMICS RESEARCH INST FDN

 M 84,000 ACTUAL COST
(3) THE TRANSLATIONAL GENOMICS RESEARCH INST FDN

 N 168,761 ACTUAL COST
(4) THE TRANSLATIONAL GENOMICS RESEARCH INST FDN

 O 3,847,275 ACTUAL COST
(5) THE TRANSLATIONAL GENOMICS RESEARCH INST FDN

 C 6,322,898 ACTUAL COST
(6)
Schedule R (Form 990) 2011
Schedule R (Form 990) 2011
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership (Complete if the organization answered "Yes" on Form 990, Part IV, line 37.)
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(e)
Are all
partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V—UBI
amount in box
20 of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2011
Schedule R (Form 990) 2011
Page 5
Part VII
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule R (see instructions).
Identifier Return Reference Explanation
Additional Data


Software ID:  
Software Version: