Form990
Click to see attachment
Department of the Treasury
Internal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except black lung benefit trust or private foundation)

MediumBullet The organization may have to use a copy of this return to satisfy state reporting requirements.
OMB No. 1545-0047
2012
Open to Public Inspection
A For the 2012 calendar year, or tax year beginning 09-01-2012 , 2012, and ending 08-31-2013
BCheck if applicable:
CName of organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Doing Business As
 
 
Number and street (or P.O. box if mail is not delivered to street address)
4000 Jones Bridge Road
Suite
Room/suite
City or town, state or country, and ZIP + 4
Chevy Chase, MD20815
D Employer identification number

59-0735717
E Telephone number

G Gross receipts $ 35,728,152,068
F Name and address of principal officer:
Robert Tjian PHD
4000 Jones Bridge Road
Chevy Chase,MD20815
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
hhmi.org
H(a)
Is this a group return for
affiliates?
H(b)
Are all affiliates included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:
 
L Year of formation: 1953
M State of legal domicile: DE
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: The Howard Hughes Medical Institute is a philanthropy that serves society through the direct conduct of biomedical research and support for programs in science education.
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 11
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 9
5 Total number of individuals employed in calendar year 2011 (Part V, line 2a) ...... 5 3,678
6 Total number of volunteers (estimate if necessary) ............. 6  
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 18,451,796
b Net unrelated business taxable income from Form 990-T, line 34 ......... 7b  
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 0 0
9 Program service revenue (Part VIII, line 2g) ......... 1,613,333 1,390,495
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 1,223,789,752 1,335,207,844
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 10,889,818 16,348,249
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)................... 1,236,292,903 1,352,946,588
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 88,120,850 59,924,253
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 405,883,741 413,980,074
16a Professional fundraising fees (Part IX, column (A), line 11e)..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet0    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 590,163,668 580,081,636
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 1,084,168,259 1,053,985,963
19 Revenue less expenses. Subtract line 18 from line 12....... 152,124,644 298,960,625
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 18,117,543,067 19,677,721,527
21 Total liabilities (Part X, line 26)............. 2,336,433,771 2,776,715,050
22 Net assets or fund balances. Subtract line 21 from line 20..... 15,781,109,296 16,901,006,477
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
 
Preparer's signature
Date
PTIN
Firm's name MediumBullet

Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ............
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y
Form 990 (2012)
Form 990 (2012)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response to any question in this Part III ...............
1
Briefly describe the organization’s mission: THE HOWARD HUGHES MEDICAL INSTITUTE ("INSTITUTE" OR "HHMI") IS THE NATION'S LARGEST PRIVATE ACADEMIC BIOMEDICAL RESEARCH INSTITUTION, WITH JUST UNDER $17 BILLION IN NET ASSETS AT THE END OF ITS 2013 FISCAL YEAR. THE MISSION OF THE INSTITUTE HAS REMAINED CONSTANT SINCE ITS FOUNDING IN 1953. AS ITS CHARTER STATES: "THE PRIMARY PURPOSE AND OBJECTIVE OF THE HOWARD HUGHES MEDICAL INSTITUTE SHALL BE THE PROMOTION OF HUMAN KNOWLEDGE WITHIN THE FIELD OF BASIC SCIENCES (PRINCIPALLY THE FIELD OF MEDICAL RESEARCH AND EDUCATION) AND THE EFFECTIVE APPLICATION THEREOF FOR THE BENEFIT OF MANKIND."
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ......................
If “Yes,” describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program services? ............................
If “Yes,” describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 726,962,490 including grants of $ 0 ) (Revenue $ 0 )
Statement 1 on Schedule O Medical Research Organization Activities (A) The HHMI Investigator Program (B) Janelia Farm Research Campus
4b (Code:   ) (Expenses $ 61,979,142 including grants of $ 40,529,770 ) (Revenue $ 0 )
Statement 2 On Schedule O Science Education Programs (A) Graduate Science Education and Medical Research Training (B) Precollege and Undergraduate Science Education Program (C) Educational Resources (D) Tangled Bank Studios (E) eLife - Open Access Journal
4c (Code:   ) (Expenses $ 37,019,395 including grants of $ 19,394,483 ) (Revenue $ 0 )
Statement 3 On Schedule O Support for International Science (A)International Early Career Scientist Program (B)Senior International Research Scholars Program (C)The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH)
4d Other program services (Describe in Schedule O.)
(Expenses $   including grants of $   ) (Revenue $   )
4e Total program service expensesMediumBullet825,961,027
Form 990 (2012)
Form 990 (2012)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If “Yes,” complete Schedule AClick to see attachment........................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? ...
2
 
No
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If “Yes,” complete Schedule C, Part IClick to see attachment..........
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If “Yes,” complete Schedule C, Part IIClick to see attachment........
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If “Yes,” complete Schedule C,
Part IIIClick to see attachment............................
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If “Yes,” complete Schedule D, Part IClick to see attachment........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If “Yes,” complete Schedule D, Part IIClick to see attachment...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If “Yes,” complete Schedule D, Part III Click to see attachment....................
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If “Yes,” complete Schedule D, Part IVClick to see attachment..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments? If “Yes,” complete Schedule D, Part VClick to see attachment......
10
 
No
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10?
If “Yes,” complete Schedule D, Part VI.Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIIClick to see attachment.......
11b
Yes
 
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIIIClick to see attachment.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part IXClick to see attachment............
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If “Yes,” complete Schedule D, Part XClick to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If “Yes,” complete Schedule D, Part XClick to see attachment.........................
11f
 
No
12a
Did the organization obtain separate, independent audited financial statements for the tax year?
If “Yes,” complete Schedule D, Parts XI and XII Click to see attachment.................
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If “Yes,” and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If “Yes,” complete Schedule E....
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States?.....
14a
Yes
 
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If “Yes,” complete Schedule F, Parts I and IV......... Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or assistance to any organization or entity located outside the United States? If “Yes,” complete Schedule F, Parts II and IVClick to see attachment
15
Yes
 
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or assistance to individuals located outside the United States? If “Yes,” complete Schedule F, Parts III and IV... Click to see attachment
16
Yes
 
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If “Yes,” complete Schedule G, Part I (see instructions)....
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If “Yes,” complete Schedule G, Part II............
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If “Yes,” complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospital facilities? If “Yes,” complete Schedule H....
20a
 
No
b
If “Yes” to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
Form 990 (2012)
Form 990 (2012)
Page 4
Part IV
Checklist of Required Schedules (continued)
21
Did the organization report more than $5,000 of grants and other assistance to any government or organization in the United States on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II... Click to see attachment
21
Yes
 
22
Did the organization report more than $5,000 of grants and other assistance to individuals in the United States on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........ Click to see attachment
22
Yes
 
23
Did the organization answer “Yes” to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If “Yes,” complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25................ Click to see list of attachments
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds?......................
24c
 
No
d
Did the organization act as an “on behalf of” issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3) and 501(c)(4) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If “Yes,” complete Schedule L, Part I........ Click to see attachment
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If “Yes,” complete Schedule L, Part I................... Click to see attachment
25b
 
No
26
Was a loan to or by a current or former officer, director, trustee, key employee, highest compensated employee, or disqualified person outstanding as of the end of the organization’s tax year? If “Yes,” complete Schedule L,
Part II.......................... Click to see attachment
26
 
No
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or family member of any of these persons? If “Yes,” complete Schedule L, Part III......... Click to see attachment
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If “Yes,” complete Schedule L, Part IV .......................... Click to see attachment
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If “Yes,”
complete Schedule L, Part IV..................... Click to see attachment
28b
 
No
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or direct or indirect owner? If “Yes,” complete Schedule L, Part IV... Click to see attachment
28c
Yes
 
29
Did the organization receive more than $25,000 in non-cash contributions? If “Yes,” complete Schedule M..
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If “Yes,” complete Schedule M.............
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If “Yes,” complete Schedule N,
Part I...........................
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If “Yes,” complete Schedule N, Part II......................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If “Yes,” complete Schedule R, Part I........ Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If “Yes,” complete Schedule R, Part II, III, or IV, and Part V, line 1........................ Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If “Yes,” complete Schedule R, Part V, line 2... Click to see attachment
35b
Yes
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If “Yes,” complete Schedule R, Part V, line 2............. Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If “Yes,” complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2012)
Form 990 (2012)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response to any question in this Part V ...............
Yes
No
1a
Enter the number reported in Box 3 of Form 1096 Enter -0- if not applicable ..
1a
900
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
3,678
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No,” provide an explanation in Schedule O.....
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)?..........................
4a
Yes
 
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for Form TD F 90-22.1, Report of Foreign Bank and Financial Accounts.
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year?..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If “Yes,” to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions?...
6a
 
No
b
If “Yes,” did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible?........................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor?....................
7a
 
No
b
If “Yes,” did the organization notify the donor of the value of the goods or services provided?.....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282?...........................
7c
 
No
d
If “Yes,” indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?............................
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract?..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?............................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C?..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds and section 509(a)(3) supporting organizations. Did the supporting organization, or a donor advised fund maintained by a sponsoring organization, have excess business holdings at any time during the year?............
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the organization make any taxable distributions under section 4966?..........
9a
 
 
b
Did the organization make a distribution to a donor, donor advisor, or related person?.......
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If “Yes,” enter the amount of tax-exempt interest received or accrued during the year. ....................
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If “No,” provide an explanation in Schedule O..
14b
 
 
Form 990 (2012)
Form 990 (2012)
Page 6
Part VI
Governance, Management, and Disclosure For each “Yes” response to lines 2 through 7b below, and for a “No” response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response to any question in this Part VI ...............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year .....................
1a
11
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent ...................
1b
9
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
 
No
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? ...........................
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
 
No
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .........................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If “Yes,” provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If “Yes,” did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If “No,” go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If “Yes,” describe in Schedule O how this was done.......................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If “Yes,” did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
AK , AZ , CA , IL , IN , MD , MA , NY , OK , OR
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how), the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, physical address, and telephone number of the person who possesses the books and records of the organization:
MediumBulletNITIN V KOTAK4000 JONES BRIDGE ROADCHEVY CHASEMD20815 (301) 215-8500
Form 990 (2012)
Form 990 (2012)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response to any question in this Part VII ...............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(1) James A Baker III Esq........................................................................
Trustee
 2.0
.......................   		X           40,000 0 0
(2) Charlene Barshefsky Esq........................................................................
Trustee
 2.0
.......................   		X           40,000 0 0
(3) Susan Desmond-Hellmann MD MPH........................................................................
Trustee, Eff 11/12
 2.0
.......................   		X           0 0 0
(4) Joseph L Goldstein MD........................................................................
Trustee
 2.0
.......................   		X           47,500 0 0
(5) Hanna H Gray PhD........................................................................
Trustee, Thru 11/12
 2.0
.......................   		X           30,000 0 0
(6) Garnett L Keith........................................................................
Trustee, Chairman Finance Comm
 4.0
.......................   		X           50,000 0 0
(7) Fred R Lummis........................................................................
Trustee
 2.0
.......................   		X           40,000 0 0
(8) Paul M Nurse PhD........................................................................
Trustee
 2.0
.......................   		X           40,000 0 0
(9) Alison M Richard PhD........................................................................
Trustee, Chairman Ed&Intl Comm
 2.0
.......................   		X           50,000 0 0
(10) Clayton S Rose PhD........................................................................
Trustee, Chairman Audit & Comp
 6.0
.......................   		X           50,000 0 0
(11) Kurt L Schmoke Esq........................................................................
Trustee, Chairman
 6.0
.......................   		X           60,000 0 0
(12) Anne M Tatlock........................................................................
Trustee
 2.0
.......................   		X           40,000 0 0
(13) Robert Tjian PhD........................................................................
President
 40.0
.......................   		    X       1,266,522 0 51,396
(14) Cheryl A Moore........................................................................
Executive VP & COO
 40.0
.......................   		    X       919,552 0 47,046
(15) Craig A Alexander Esq........................................................................
VP,Gen Counsel/Sec ret 4/13
 40.0
.......................   		    X       579,974 0 50,564
(16) Sean B Carroll PhD........................................................................
VP for Science Education
 40.0
.......................   		    X       633,016 0 45,613
(17) Jack E Dixon PhD........................................................................
VP/Chief Sci Off retired 6/13
 40.0
.......................   		    X       742,624 0 51,130
Form 990 (2012)
Form 990 (2012)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(18) Heidi E Henning Esq........................................................................
VP,General Counsel/Sec Eff6/13
 40.0
.......................   		    X       432,168 0 46,865
(19) Mohamoud Jibrell........................................................................
VP for Information Technology
 40.0
.......................   		    X       295,082 0 48,164
(20) Nitin V Kotak........................................................................
VP, CFO & Treasurer
 40.0
.......................   		    X       393,339 0 45,050
(21) Erin K O'Shea PhD........................................................................
VP & Chief Sci Off Eff 7/13
 40.0
.......................   		    X       300,842 0 44,852
(22) Gerald M Rubin PhD........................................................................
VP&Exec Director,Janelia Farm
 40.0
.......................   		    X       687,226 0 114,231
(23) Kathy Wyszynski........................................................................
VP, Human Resources
 40.0
.......................   		    X       264,373 0 34,274
(24) Landis Zimmerman........................................................................
VP & Chief Investment Officer
 40.0
.......................   		    X       1,887,293 0 48,567
(25) Lauren T Spiliotes Esq........................................................................
Dep GenCounsel/Asst SecEff6/13
 40.0
.......................   		    X       293,614 0 50,682
(26) Susan S Plotnick........................................................................
Assistant Treasurer
 40.0
.......................   		    X       226,779 0 44,205
(27) Monique L Marcus........................................................................
Assistant Controller
 40.0
.......................   		    X       177,128 0 37,442
(28) Richard A Pender........................................................................
Man Dir - US Equities
 40.0
.......................   		      X     1,118,361 0 46,448
(29) Robert J Kolyer Jr........................................................................
Man Dir - Diversified Assets
 40.0
.......................   		      X     1,053,805 0 47,032
(30) Stephen M Kitsoulis........................................................................
Man Dir - Fixed Income
 40.0
.......................   		      X     799,980 0 47,989
(31) Mark A Barnard........................................................................
Man Dir - Private Equities
 40.0
.......................   		      X     812,655 0 47,189
(32) Matthew R Lee........................................................................
Man Dir - Portfolio Strategies
 40.0
.......................   		        X   715,313 0 47,899
(33) Anil Madhok........................................................................
Man Dir - Investments & COO
 40.0
.......................   		        X   681,061 0 45,985
(34) William R Bishai PhD........................................................................
Director, K-RITH
 40.0
.......................   		        X   560,736 0 45,586
(35) Eric R Kandel MD........................................................................
Senior Investigator
 40.0
.......................   		        X   553,157 0 53,231
(36) Ryan L Matney........................................................................
Director - Diversified Assets
 40.0
.......................   		        X   517,097 0 43,328
(37) Thomas R Cech PhD........................................................................
Investigator
 40.0
.......................   		          X 583,547 0 48,100
(38) Avice A Meehan........................................................................
VP Communications
 0.0
.......................   		          X 363,844 0 14,693
(39) David A Clayton PhD........................................................................
Group Leader
 40.0
.......................   		          X 109,543 0 32,042
1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)............MediumBullet 17,456,131 0 1,279,603
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organizationMediumBullet708
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If “Yes,” complete Schedule J for such individual ..............
3
Yes
 
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If “Yes,” complete Schedule J for such individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If “Yes,” complete Schedule J for such person ........
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
Aramark Harrison Lodging, 1101 Market StPHILADELPHIAPA19107 Conference Ctr Mgt 3,721,544
Southeastern Asset Management, 6410 Poplar Avenue Suite 900MEMPHISTN38119 Investment Mgt 3,696,768
Walter Scott Partners Ltd, ONE CHARLOTTE SQUAREEDINBURGHMIDLOTHIANUKEH2 4DZ Investment Mgt 2,842,446
Invention Investment Fund II LLC, 1756 114th Avenue SEBELLEVUEWA98004 INVESTMENT MGT 2,500,000
Echo Street Capital MgtLLCVIA HHM, 850 Third AvenueNEW YORKNY10022 INVESTMENT MGT 2,460,428
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet156
Form 990 (2012)
Form 990 (2012)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response to any question in this Part VIII ..............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512, 513, or 514
Contributions, Gifts, Grants and Other Similar Amounts 1a Federated campaigns..1a  
b Membership dues....1b  
c Fundraising events....1c  
d Related organizations...1d  
e Government grants (contributions)1e  
f All other contributions, gifts, grants, and
similar amounts not included above1f 		 
g Noncash contributions included in lines
1a-1f:$ 		 
h Total. Add lines 1a-1f.......MediumBullet 0
Program Service Revenue Business Code
2a RENTAL INCOME 900099 1,390,495 1,390,495    
b
c
d
e
f All other program service revenue .        
g Total. Add lines 2a–2f........MediumBullet 1,390,495
Other Revenue 3 Investment income (including dividends, interest, and other similar amounts).......MediumBullet 236,498,389   15,167,218 221,331,171
4 Income from investment of tax-exempt bond proceeds..MediumBullet 572,141     572,141
5 Royalties...........MediumBullet 15,786,706     15,786,706
(i) Real (ii) Personal
6a Gross rents 1,535,800  
b Less: rental expenses 1,483,512  
c Rental income or (loss) 52,288 0
d Net rental income or (loss).......MediumBullet 52,288   -2,354 54,642
(i) Securities (ii) Other
7a Gross amount from sales of assets other than inventory 35,468,572,350 3,286,932
b Less: cost or other basis and sales expenses 34,373,721,968 0
c Gain or (loss) 1,094,850,382 3,286,932
d Net gain or (loss)..........MediumBullet 1,098,137,314   3,286,932 1,094,850,382
8a Gross income from fundraising events (not including
$  
of contributions reported on line 1c). See Part IV, line 18 ..
a  
b Less: direct expenses ...b  
c Net income or (loss) from fundraising events..MediumBullet 0    
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities...MediumBullet 0      
10a Gross sales of inventory, less
returns and allowances .
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet 0      
Miscellaneous Revenue Business Code
11a CAFETERIA INCOME 900099 203,048     203,048
b INVESTMENT EXPENSE REBATE 900099 158,425     158,425
c CASH DISCOUNTS 900099 80,611     80,611
d All other revenue .... 67,171     67,171
e Total. Add lines 11a–11d ...... MediumBullet 509,255
12 Total revenue. See Instructions......MediumBullet 1,352,946,588 1,390,495 18,451,796 1,333,104,297
Form 990 (2012)
Form 990 (2012)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response to any question in this Part IX ...............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to governments and organizations in the United States. See Part IV, line 21 25,186,988 25,186,988
2 Grants and other assistance to individuals in the United States. See Part IV, line 22 15,342,782 15,342,782
3 Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16 19,394,483 19,394,483
4 Benefits paid to or for members 0  
5 Compensation of current officers, directors, trustees, and key employees .... 16,052,298 2,708,220 13,344,078  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .... 778,065 778,065    
7 Other salaries and wages 269,729,778 242,912,489 26,817,289 0
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 23,571,864 21,414,481 2,157,383  
9 Other employee benefits ....... 86,237,132 78,129,041 8,108,091  
10 Payroll taxes ........... 17,610,937 15,762,862 1,848,075  
11 Fees for services (non-employees):        
a Management ...... 0      
b Legal ......... 4,566,131 2,212,102 2,354,029  
c Accounting ........... 942,282 1,412 940,870  
d Lobbying ........... 0      
e Professional fundraising services. See Part IV, line 17 0  
f Investment management fees ...... 70,571,569   70,571,569  
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) ........ 36,360,339 26,414,598 9,945,741  
12 Advertising and promotion .... 0      
13 Office expenses ....... 7,631,657 4,855,658 2,775,999  
14 Information technology ...... 7,267,714 470,714 6,797,000  
15 Royalties .. 15,935   15,935  
16 Occupancy ........... 103,905,072 103,248,334 656,738  
17 Travel ............ 8,181,748 6,778,245 1,403,503  
18 Payments of travel or entertainment expenses for any federal, state, or local public officials ...... 0      
19 Conferences, conventions, and meetings .... 3,493,475 3,007,136 486,339  
20 Interest ........... 65,334,622 334,190 65,000,432  
21 Payments to affiliates ....... 0      
22 Depreciation, depletion, and amortization ..... 100,629,733 90,657,117 9,972,616  
23 Insurance .............. 345,166 44,405 300,761  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a LAB & OTHER SCIENTIFIC SUPPLIE 141,013,013 140,173,508 839,505  
b MINOR EQUIPMENT & RENOVATIONS 11,431,705 9,604,343 1,827,362  
c EQUIPMENT MAINTENANCE 11,690,420 12,036,215 -345,795  
d PRINTING AND PUBLICATIONS 3,870,129 2,425,485 1,444,644  
e All other expenses 2,830,926 2,068,154 762,772  
25 Total functional expenses. Add lines 1 through 24e 1,053,985,963 825,961,027 228,024,936 0
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2012)
Form 990 (2012)
Page 11
Part X Balance Sheet Check if Schedule O contains a response to any question in this Part X ...............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash—non-interest-bearing ............. 0 1 0
2 Savings and temporary cash investments ......... 804,224,304 2 374,609,412
3 Pledges and grants receivable, net ........... 0 3 0
4 Accounts receivable, net ............. 0 4 0
5 Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
Schedule L ..................
0 5 0
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
0 6 0
7 Notes and loans receivable, net ............. 0 7 0
8 Inventories for sale or use .............. 0 8 0
9 Prepaid expenses and deferred charges .......... 2,313,253 9 7,388,741
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 1,800,651,787
b Less: accumulated depreciation ..... 10b 986,220,004 833,695,225 10c 814,431,783
11 Investments—publicly traded securities .......... 7,333,976,572 11 7,407,499,312
12 Investments—other securities. See Part IV, line 11 ..... 8,867,228,423 12 10,892,032,785
13 Investments—program-related. See Part IV, line 11 ..... 0 13 0
14 Intangible assets ............... 0 14 0
15 Other assets. See Part IV, line 11 ........... 276,105,290 15 181,759,494
16 Total assets. Add lines 1 through 15 (must equal line 34)...... 18,117,543,067 16 19,677,721,527
Liabilities 17 Accounts payable and accrued expenses ......... 379,269,548 17 387,750,043
18 Grants payable ................. 127,237,303 18 106,249,684
19 Deferred revenue ................ 0 19 0
20 Tax-exempt bond liabilities ............. 683,000,000 20 716,130,000
21 Escrow or custodial account liability. Complete Part IV of Schedule D.. 0 21 0
22 Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L.......... 0 22 0
23 Secured mortgages and notes payable to unrelated third parties .. 0 23 0
24 Unsecured notes and loans payable to unrelated third parties .... 640,376,000 24 1,237,912,529
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D.................... 506,550,920 25 328,672,794
26 Total liabilities. Add lines 17 through 25......... 2,336,433,771 26 2,776,715,050
Net Assets or Fund Balance Organizations that follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets .............. 15,781,109,296 27 16,901,006,477
28 Temporarily restricted net assets ........... 0 28 0
29 Permanently restricted net assets ........... 0 29 0
Organizations that do not follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds ........   30  
31 Paid-in or capital surplus, or land, building or equipment fund .....   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ........... 15,781,109,296 33 16,901,006,477
34 Total liabilities and net assets/fund balances ........ 18,117,543,067 34 19,677,721,527
Form 990 (2012)
Form 990 (2012)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response to any question in this Part XI ...............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
1,352,946,588
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
1,053,985,963
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
298,960,625
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) ..
4
15,781,109,296
5
Net unrealized gains (losses) on investments ...............
5
820,936,556
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
 
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 33, column (B))
10
16,901,006,477
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response to any question in this Part XII ..............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If “Yes,” to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
 
No
b
If “Yes,” did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits
3b
 
 
Form 990 (2012)
Form 990, Special Condition Description:
Special Condition Description
Additional Data


Software ID:  
Software Version:  
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ. right arrow See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
Attachment 1,
  ,
Chevy Chase, MD  
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
f
g
(i) A person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the supported organization? ................
11g(i)
 
 
(ii) A family member of a person described in (i) above? ......................
11g(ii)
 
 
(iii) A 35% controlled entity of a person described in (i) or (ii) above? ................
11g(iii)
 
 
h
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) (iv) Is the organization in col. (i) listed in your governing document? (v) Did you notify the organization in col. (i) of your support? (vi) Is the organization in col. (i) organized in the U.S.? (vii) Amount of monetary support
Yes No Yes No Yes No
Total                  

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....            
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3            
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..            
6 Public support. Subtract line 5 from line 4.            
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
7 Amounts from line 4..            
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...            
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)..            
11 Total support (Add lines 7 through 10).            
12
12
 
13
First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization, check this box and stop here........................................right arrow
Section C. Computation of Public Support Percentage
14
14
 
15
15
 
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513..            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support (Subtract line 7c from line 6.)            
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 4
Part IV
Supplemental Information. Complete this part to provide the explanations required by Part II, line 10; Part II, line 17a or 17b; and Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Explanation
The Institute is a medical research organization for its taxable year ended August 31, 2013, as its expenditures of $800,418,284 on a cash basis for the year ended August 31, 2012 exceeded the MRO requirement of $591,944,966 (3.5% of the HHMI endowment).
List of hospital affiliations for e-filing: Hospital,City,State,Zip Code/ B&W Hospital,Boston,MA,02115/ Children's Hosp,Boston,MA,02115/ Children's Hosp,Cincinnati,OH,45229/ Dana-Farber,Boston,MA,02115/ Fred Hutch,Seattle,WA,98109/ JHopkins Hosp,Baltimore,MD,21205/ Mass Gen Hosp,Boston,MA,02129/ MSKCC,New York,NY,10021/ Nat'l Jewish,Denver,CO,80206/ St. Jude,Memphis,TN,38105/ Duke-Duke Hosp,Durham,NC,27706/ Emory-Univ Hosp,Atlanta,GA,30322/ NYU-NYU Hosps,New York,NY,10016/ OHSU-OHSU Hosp,Portland,OR,97239/ Rockefeller-Hosp,New York,NY,10021/ Stanford-Hosp,Palo Alto,CA,94305/ UCLA-Med Ctr,Los Angeles,CA,90095/ UCSD-Med Ctr,San Diego,CA,92093/ UCSF-UCSF Hosps,San Francisco,CA,94143/ UIowa-UIowa Hosps,Iowa City,IA,52242/ UMass-Med Ctr,Worcester,MA,01605/ UMich-UMich Hosp,Ann Arbor,MI,48109/ UPenn-UPenn Hosp,Philadelphia,PA,19104/ UT-Austin-UT Hosp,Austin,TX,78712/ UTSW-UTSW Hosps,Dallas,TX,75390/ UUtah-UUtah Hosps,Salt Lake City,UT,84112/ UWash-Med Ctr,Seattle,WA,98195/ ADARC-aff hosp,New York,NY,10016/ AECOM-affil hosps,New York,NY,10461/ Baylor-aff hosps,Houston,TX,77030/ BU-aff hosp,Boston,MA,02126/ Brandeis-aff hsps,Waltham,MA,02254/ CalTech-aff hosps,Pasadena,CA,91125/ Carnegie-aff hsps,Baltimore,MD,21210/ Case WR-aff hosps,Cleveland,OH,44106/ CSHL-affil hosps,Cold Spring Harbor,NY,11724/ CSU-affil hosp,Fort Collins,CO,80521/ Columbia-aff hsps,New York,NY,10027/ Cornell-aff hosps,New York,NY,14853/ Harvard-aff hosps,Cambridge,MA,02138/ Indiana-affil hosp,Bloomington,IN,47405/ TJL-affil hosps,Bar Harbor,ME,04609/ JHU-affil hosps,Baltimore,MD,21218/ MichSU-affil hosps, Lansing,MI,48824/ MIT-affil hosps,Boston,MA,02139/ NWU-affil hosps,Evanston,IL,60208/ OMRF-aff hosp,Oklahoma City,OK,73104/ Princeton-aff hosps,Princeton,NJ,08544/ Purdue-aff hosp,W.Lafayette,IN,47907/ Rutgers-affil hosp,Piscataway,NJ,08854/ Salk-affil hosps,La Jolla,CA,92093/ Stowers-aff hosps,Kansas City,MO,64110/ SUNY-affil hosps,Stony Brook,NY,11794/ Texas A&M-aff hsp,College Station,TX,77843/ Tufts-aff hosps,Boston,MA,02111/ UCB-affil hosps,Berkeley,CA,94720/ UC-Davis-affil hsps,Davis,CA,95616/ UCR-affil hosps,Riverside,CA,92521/ UCSC-aff hosps,Santa Cruz,CA,95064/ UChi-affil hosp,Chicago,IL,60637/ UColo-aff hosp,Boulder,CO,80309/ UColo-aff hosp,Denver,CO,80217/ UFla-aff hosps,Gainesville,FL,32611/ UIllinois-aff hsp,Urbana,IL,61801/ UMD-affil hosp,Baltimore,MD,21201/ UNC-affil hosps,Chapel Hill,NC,27599/ UOregon-aff hsp,Eugene,OR,97403/ UWisc-affil hosps,Madison,WI,53706/ WashU-aff hosp,St.Louis,MO,63130/ YaleU-affil hosp,New Haven,CT,06520/
 
 
Schedule A (Form 990 or 990-EZ) 2012

Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet Complete if the organization is described below.SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd Bullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
If the organization answered “Yes” to Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered “Yes” to Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered “Yes” to Form 990, Part IV, Line 5 (Proxy Tax) or Form 990-EZ, Part V, line 35c (Proxy Tax), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV.
2
Political expenditures ....................................SchCMd Bullet
$  
3
Volunteer hours ........................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 .........SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 ......SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ..............
4a
Was a correction made? .........................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ...................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b..SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ..........................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.










For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2012

Schedule C (Form 990 or 990-EZ) 2012
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
organization's
totals 		(b) Affiliated group
totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......    
b Total lobbying expenditures to influence a legislative body (direct lobbying) .......    
c Total lobbying expenditures (add lines 1a and 1b) ...................    
d Other exempt purpose expenditures ........................    
e Total exempt purpose expenditures (add lines 1c and 1d) ...............    
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		    
  If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:    
  Not over $500,00020% of the amount on line 1e.    
  Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.    
  Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.    
  Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.    
  Over $17,000,000$1,000,000.    
       
g Grassroots nontaxable amount (enter 25% of line 1f) .................    
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................    
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................    
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ......................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the instructions for lines 2a through 2f on page 4.)
Lobbying Expenditures During 4-Year Averaging Period
  Calendar year (or fiscal year
beginning in) 		(a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) Total
             
2a Lobbying nontaxable amount          
             
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		         
             
c Total lobbying expenditures          
             
d Grassroots nontaxable amount          
             
e Grassroots ceiling amount
(150% of line 2d, column (e))		          
             
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2012


Schedule C (Form 990 or 990-EZ) 2012
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each “Yes” response to lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
No
Yes
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? .........................................
 
No
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ....
 
No
c
Media advertisements? ....................................
 
No
 
d
Mailings to members, legislators, or the public? .........................
 
No
 
e
Publications, or published or broadcast statements? .......................
 
No
 
f
Grants to other organizations for lobbying purposes? .......................
 
No
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? ........
Yes
 
77,632
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ......
 
No
 
i
Other activities? ..........................
Yes
 
1,090
j
Total. Add lines 1c through 1i ...............................
78,722
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
No
b
If "Yes," enter the amount of any tax incurred under section 4912 .................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 .....
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? .......
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? ..........
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered “No” OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members .....................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).
a
Current year .........................................
2a
 
b
Carryover from last year ....................................
2b
 
c
Total ............................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) ..............
5
 
Part IV
Supplemental Information
Complete this part to provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, line 2; and Part ll-B, line 1. Also, complete this part for any additional information.
Identifier Return Reference Explanation
Direct Contact with Legislators etc. Schedule C, Part II-B, line 1g (Direct Contact) During the fiscal year, HHMI engaged in lobbying activities in connection with the proposed Montgomery County Council's action to adopt the Chevy Chase Lake Sector Plan. HHMI retained a registered lobbyist to provide advice, conduct research, prepare comments, and engage in direct contacts with County staff and Council members on the draft Sector Plan on behalf of HHMI.
Other Activities Schedule C, Part II-B, line 1i (Other Activities) During the fiscal year, HHMI was a member of a number of non-profit organizations that engaged in lobbying activities on behalf of their memberships. HHMI is reporting as lobbying expenditures a portion of the membership dues that HHMI paid to these organizations.
Schedule C (Form 990 or 990EZ) 2012

Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b
SchDMd Bullet Attach to Form 990. SchDMd Bullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate contributions to (during year) ...    
3 Aggregate grants from (during year) .....    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ....................... 2a  
b Total acreage restricted by conservation easements .................. 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register .................... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................
6
Staff and volunteer hours devoted to monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .......................................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenues included in Form 990, Part VIII, line 1 ........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ..............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958) relating to these items:
a
Revenues included in Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b
If "Yes," explain the arrangement in Part XIII and complete the following table:
Amount
c Beginning balance ................................. 1c  
d Additions during the year .............................. 1d  
e Distributions during the year ............................. 1e  
f Ending balance ................................... 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21? .....................
b
If “Yes,” explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ........
Part V
Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.
(a)Current year (b)Prior year b (c)Two years back (d)Three years back (e)Four years back
1a Beginning of year balance ....          
b Contributions ........          
c Net investment earnings, gains, and losses          
d Grants or scholarships .....          
e Other expenditures for facilities
and programs ........ 		         
f Administrative expenses ....          
g End of year balance ......          
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Temporarily restricted endowment SchDMd Bullet  
The percentages in lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations ........................
3a(i)
 
 
(ii) related organizations ........................
3a(ii)
 
 
b
If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis (investment) (b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land ................. 807,737 37,588,922 38,396,659
b Buildings ................ 10,496,661 686,610,602 183,731,443 513,375,820
c Leasehold improvements ............ 2,878,464 463,846,330 397,720,338 69,004,456
d Equipment ................   541,022,267 404,226,875 136,795,392
e Other ................. 921,448 56,479,356 541,348 56,859,456
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).).......SchDMdBullet 814,431,783
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 3
Part VII
Investments—Other Securities. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c) Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
(3)Other
(A) PRIVATE EQUITY & REAL ESTATE 		4,713,549,512 F

(B) NATURAL RESOURCES 		340,679,756 F

(C) ALTERNATIVE INVESTMENTS 		5,837,803,517 F






Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet 10,892,032,785
Part VIII
Investments—Program Related. See Form 990, Part X, line 13.
(a) Description of investment type (b) Book value (c) Method of valuation:
Cost or end-of-year market value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. See Form 990, Part X, line 15.
(a) Description (b) Book value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
Federal income taxes 0
SHORT POSITIONS 142,253,221
INVESTMENT PURCH. PENDING SALES 66,100,369
SWAP UNREALIZED LOSS 61,111,197
MANAGEMENT FEES PAYABLE 11,064,866
DEFERRED COMPENSATION LIAB. 26,038,413
CURRENCY EXCH. CONTRACTS PAY. 13,325,151
NEGATIVE CASH 7,194,183
CREDIT DEFAULT SWAP 787,531
DERIVATIVE LIABILITIES 773,553
PAY. REALIZED GAINS ON FUTURES 24,310
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 328,672,794
2. Fin 48 (ASC 740) Footnote. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII .....................................................
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return
1 Total revenue, gains, and other support per audited financial statements ....... 1 2,076,890,908
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains on investments .......... 2a 820,936,556
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d ..................... 2e 820,936,556
3 Subtract line 2e from line 1..................... 3 1,255,954,352
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a 96,992,236
b Other (Describe in Part XIII.) ........... 4b  
c Add lines 4a and 4b....................... 4c 96,992,236
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 1,352,946,588
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return
1 Total expenses and losses per audited financial statements ........... 1 956,993,727
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities .......... 2a  
b Prior year adjustments .............. 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d...................... 2e  
3 Subtract line 2e from line 1..................... 3 956,993,727
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a 96,992,236
b Other (Describe in Part XIII.) ............ 4b  
c Add lines 4a and 4b....................... 4c 96,992,236
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 1,053,985,963
Part XIII
Supplemental Information
Complete this part to provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Identifier Return Reference Explanation
Schedule D (Form 990) 2012

Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
General Information on Activities Outside the United States. Complete if the organization answered “Yes” to Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of the grants or
assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used to award
the grants or assistance? ...................................
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of grant funds outside
the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in region (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total expenditures
for and investments
in region
Sub-Saharan Africa   1 Program Services Medical Research 19,304,483
Sub-Saharan Africa     Investments   7,987,828
North America     Grantmaking Grants for TB/HIV 75,000
North America     Investments   146,223,257
Europe (Including Iceland and Greenland)     Grantmaking Investigator Education 15,000
Europe (Including Iceland and Greenland)     Investments   568,434,358
East Asia and the Pacific     Investments   1,157,080
Central America and the Caribbean     Investments   3,168,833,893
           
           
           
           
           
           
           
           
           
3a Sub-total .....   1 3,912,030,899
b Total from continuation sheets to Part I ...      
c Totals (add lines 3a and 3b)   1 3,912,030,899
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered “Yes” to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount of
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
Sub-Saharan Africa HIV/TB research 75,000 Check      
Europe (Including Iceland and Greenland) Investigator Educational 15,000 WT      
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter ....MediumBullet
2
3
Enter total number of other organizations or entities .......................MediumBullet
 
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If “Yes,”the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926)......................................
2 Did the organization have an interest in a foreign trust during the tax year? If “Yes,” the organizationmay be required to file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A).......................................
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471)..............................
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If "Yes," the organization may be required to file Form 8621, Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621)
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships. (see Instructions for Form 8865)....................................
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see Instructions for Form 5713)................................................
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 5
Part V
Supplemental Information
Complete this part to provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).
Identifier ReturnReference Explanation
Monitoring of foreign grant funds Schedule F, Part 1, Line 2 During its 2013 fiscal year, HHMI continued to support International Research Scholars selected through one or more competitions open to all eligible applicants. Eligibility requirements included, but were not limited to, a full-time appointment at a nonprofit scientific research organization in a country other than the United States, and a research focus on basic biological processes or disease mechanisms. Qualified applicants were evaluated by a panel of scientific experts with final selections made by HHMI leadership. The disbursement of grant funds to support the work of International Early Career Scientists and Senior International Research Scholars is made in accordance with all applicable U.S. laws. Funds are paid to an institutional account. In order to monitor the activities and productivity of the grants, each scientist is required to submit an annual progress report concerning his or her research and each grantee institution is required to submit annual financial reports. These reports are reviewed by HHMI staff. Site visits and audits are conducted if warranted and grantees attend scientific meetings of HHMI US-based scientists. HHMI makes regular expenditures as part of its commitment of over $70 million to support the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) over 10 years. As discussed in further detail on Schedule O, HHMI and the University of KwaZulu-Natal (UKZN) in South Africa have collaborated on establishing K-RITH as an international research center in Durban, South Africa. K-RITH's mission is the conduct of outstanding basic scientific research on tuberculosis (TB) and HIV, translating the scientific findings into new insights or tools to control the devastating co-epidemic of TB and HIV, and helping to train a new generation of scientists in Africa. K-RITH is an independent non-profit association incorporated under South African law. More information about K-RITH is available from its website, (http://www.k-rith.org/). As part of its oversight of the K-RITH project, HHMI receives regular, detailed financial and programmatic reporting from K-RITH of its spending of HHMI's financial support on at least a quarterly basis. In addition, HHMI has seconded an employee to serve as Interim Director of K-RITH while K-RITH searches for a Director,and HHMI is represented on the K-RITH governing board. HHMI employees serve on various K-RITH advisory boards, make regular visits to K-RITH, and are in frequent contact with K-RITH staff to receive program and financial updates.
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
Schedule F (Form 990) 2012
Additional Data


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Software Version:  



Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," to Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number
59-0735717
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ....................................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Governments and Organizations in the United States. Complete if the organization answered "Yes" to
Form 990, Part IV, line 21, for any recipient that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government		 (b) EIN (c) IRC Code section
if applicable		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
non-cash assistance		 (h) Purpose of grant
or assistance
(1) Travel Exps paid-behalf-grantees-AMR Corp
4333 Amon Carter Blvd
Fort Worth,TX76155 		75-1825172   7,280       EXROP Program - Housing
(2) UC San Francisco
UC San Francisco
San Francisco,CA94143 		94-6036493 501 (c) (3) 23,322       EXROP Program - Housing
(3) Housing paid-behalf-grantees-Carl Hotel
198 Carl St
San Francisco,CA94117 		94-3356764   12,190       EXROP Program - Housing
(4) Cold Spring Harbor Laboratory
Cold Spring
Cold Spring Harbor,NY11724 		11-2013303 501 (c) (3) 17,400       EXROP Program - Housing
(5) Univ of Washington
Univ of Washington
Seattle,WA98195 		91-6001537 501 (c) (3) 14,838       EXROP Program - Housing
(6) Stanford Univ
Stanford Univ
Palo Alto,CA94305 		94-1156365 501 (c) (3) 10,367       EXROP Program - Housing
(7) Massachusetts Institute of Technology
MIT
Cambridge,MA02139 		04-2103594 501 (c) (3) 7,104       EXROP Program - Housing
(8) Travel Exps paid-behalf-grantees-Longwood Inn
123 Longwood Avenue
Brookline,MA02446 		04-2932331   6,593       EXROP Program - Housing
(9) WETA
3939 Campbell Avenue
Arlington,VA22206 		53-0242992 501 (c) (3) 125,000       Greater PBS Newshour
(10) Travel Exps paid behalf grantees - United
233 S Wacker Dr
Chicago,IL60606 		74-2099724   8,806       EXROP Program - Housing
(11) Univ of Michigan
Univ of Michigan
Ann Arbor,MI48109 		38-6006309 501 (c) (3) 8,682       EXROP Program - Housing
(12) Montgomery Cty PS Educ Found
850 Hungerford Drive
Rockville,MD20850 		52-1804509 501 (c) (3) 1,635,000       Precollege Local Inititative
(13) Univ of Illinois
Univ of Illinois
Champaign,IL61820 		37-6000511 501 (c) (3) 7,953       EXROP Program - Housing
(14) Loudoun Cty Public Schools
21000 Education Court
Leesburg,VA20176 		54-6001395 VA county 1,000,000       PreCollege Science - Other
(15) NYU
New York University
New York,NY10003 		13-5562308 501 (c) (3) 30,000       NOVA
(16) Univ of Minnesota
Univ of Minnesota
Minneapolis,MN55415 		41-6007513 501 (c) (3) 380,956       Summer Institute
(17) UC Los Angeles
UC Los Angeles
Los Angeles,CA90095 		95-6006143 501 (c) (3) 172,788       Summer Institute
(18) Yale Univ
Yale Univ
New Haven,CT06520 		06-0646973 501 (c) (3) 60,000       Summer Institute
(19) Amer Inst of Biological Sciences
1900 Campus Commons Dr
Reston,VA20191 		53-0220853 501 (c) (3) 56,386       Summer Institute
(20) Univ of North Carolina
UNC
Chapel Hill,NC27599 		56-6001393 501 (c) (3) 250,000       Universities
(21) Univ of Maryland
Univ of Maryland
Baltimore,MD21201 		52-6002033 501 (c) (3) 182,000       Universities
(22) Beth Israel Deaconess Medical Ctr
Beth Israel
Boston,MA02215 		04-2103881 501 (c) (3) 124,711       Early Career Awards
(23) Biological Sciences Curriculum Study
CO State Univ
Colorado Springs,CO80918 		84-0622557 501 (c) (3) 170,000       BSCS-NOVA
(24) ResearchAmerica
1101 King St Ste 520
Alexandria,VA22314 		52-1609875 501 (c) (3) 25,000       Assessment
(25) Natl Academy - Sciences
2101 Constitution Ave NW
Wash,DC20001 		53-0196932 501 (c) (3) 50,000       Local Area
(26) American Society - Cell Biology
8120 Woodmont Avenue
Bethesda,MD20814 		39-6054285 501 (c) (3) 60,000       Local Area
(27) UC - San Diego
UC - San Diego
La Jolla,CA92093 		39-6054285 501 (c) (3) 6,566       EXROP Program - Housing
(28) Travel Exps paid behalf grantees - Mermaid Inn
727 El Camino Real
Menlo Park,CA94025 		  5,604       EXROP Program - Housing
(29) Johns Hopkins Univ
Johns Hopkins Univ
Baltimore,MD21218 		52-0595110 501 (c) (3) 5,474       EXROP Program - Housing
(30) Travel Exps paid behalf grantees - US Airways
111 W Rio Salado Pkwy
Tempe,AZ85281 		53-0218143   5,414       EXROP Program - Housing
(31) Cornell Univ
Cornell Univ
Ithaca,NY14853 		15-0532082 501 (c) (3) 5,338       EXROP Program - Housing
(32) Travel Exps paid behalf grantees - Permier Hotel
Long Wharf Dr
New Haven,CT06511 		  5,190       EXROP Program - Housing
(33) Yale Univ
Yale Univ
New Haven,CT06520 		06-0646973 501 (c) (3) 5,070       EXROP Program - Housing
(34) Hope College
Hope College
Holland,MI49423 		38-1381271 501 (c) (3) 50,000       College
(35) Macalester College
Macalester College
St Paul,MN55105 		41-0693962 501 (c) (3) 50,000       College
(36) Milsaps College
Milsaps College
Jackson,MS39210 		64-0303084 501 (c) (3) 50,000       College
(37) UC - Davis
UC - Davis
Davis,CA95616 		94-6036494 501 (c) (3) 60,000       Medical into Graduate
(38) Cornell Univ
Cornell Univ
Ithaca,NY14853 		15-0532082 501 (c) (3) 60,000       Medical into Graduate
(39) Univ of Alabama - Birmingham
UAB
Birmingham,AL35294 		63-6005396 501 (c) (3) 60,000       Medical into Graduate
(40) Ohio State Univ
Ohio State Univ
Columbus,OH43210 		31-6401599 501 (c) (3) 60,000       Medical into Graduate
(41) UC - San Francisco
UC - San Francisco
San Francisco,CA94143 		94-6036493 501 (c) (3) 60,000       Medical into Graduate
(42) Natl Math & Science Initiative
Natl Math Sci Initiative
Dallas,TX75206 		11-3769438 501 (c) (3) 21,250,000       Biomedical Research Inst
(43) Penn State Univ
Penn State Univ
University Park,PA16802 		24-6000376 501 (c) (3) 40,000       Curriculum Collaborative
(44) Univ of North Carolina
UNC
Chapel Hill,NC27599 		56-6001393 501 (c) (3) 40,000       Curriculum Collaborative
(45) Cal Poly State Univ
Cal Poly
San Luis Obispo,CA93407 		20-4927897 501 (c) (3) 50,000       SEA
2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................ Bullet Image
38
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
7
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2012

Schedule I (Form 990) 2012
Page 2
Part III
Grants and Other Assistance to Individuals in the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a)Type of grant or assistance (b)Number of
recipients		 (c)Amount of
cash grant		 (d)Amount of
non-cash assistance		 (e)Method of valuation (book,
FMV, appraisal, other)		 (f)Description of non-cash assistance
(1) EXROP Program 100 526,123      
(2) Gilliam Fellowships 32 1,488,000      
(3) Science Education Fellows 2 62,878      
(4) International Predoctoral Fellowship Program 107 4,587,572      






Part IV
Supplemental Information.
Complete this part to provide the information required in Part I, line 2, Part III, column (b), and any other additional information.
Identifier Return Reference Explanation
Monitoring of Grants funds Schedule I, Part 1, Line 2 HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the U.S. through periodic national competitions for which select institutions are eligible to apply. Each program sets out specific criteria and objectives; proposals are evaluated by a panel of experts with the final selection made by HHMI leadership. The Institute also awards fellowships to international predoctoral students; to medical students seeking to conduct basic laboratory research; to doctoral students (the Gilliam Fellows), and to early career physician scientists. These grants are also awarded on a competitive basis. A small number of grants are awarded based on direct application to HHMI for specific initiatives directly related to science education. The disbursement of funds occurs principally through institutions: biomedical research institutions, universities, and colleges. HHMI grantees are required to file annual progress reports that detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds. These are subject to careful review and analysis by HHMI staff with more detailed review by the Institute auditors as warranted. The Institute continues to assess reporting requirements to ensure the quality and timeliness of both financial and programmatic reports. In addition to site visits made by HHMI staff, program directors meet on a regular basis to discuss their activities and share information about best educational practices.
Schedule I (Form 990) 2012


Additional Data


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Software Version:  


Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" to Form 990,
Part IV, question 23.
SchJMediumBullet Attach to Form 990. SchJMediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all officers,
directors, trustees, and the CEO/Executive Director, regarding the items checked in line 1a? .......
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ................
4a
 
No
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.
5
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization? .........................
5b
 
No
If "Yes," to line 5a or 5b, describe in Part III.
6
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ...........................
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," to line 6a or 6b, describe in Part III.
7
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
Yes
 
9
If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
Yes
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2012

Schedule J (Form 990) 2012
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation
reported as deferred
in prior Form 990
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
(1)Robert Tjian PhDPresident (i)
(ii)		 1,243,132
0 		0
  		23,390
  		25,000
  		26,396
  		1,317,918
0 		 
 
(2)Cheryl A MooreExecutive VP & COO (i)
(ii)		 796,650
0 		5,000
  		117,902
  		25,000
  		22,046
  		966,598
0 		 
 
(3)Craig A Alexander EsqVP,Gen Counsel/Sec ret 4/13 (i)
(ii)		 562,157
0 		0
  		17,817
  		25,000
  		25,564
  		630,538
0 		 
 
(4)Sean B Carroll PhDVP for Science Education (i)
(ii)		 614,582
0 		0
  		18,434
  		25,000
  		20,613
  		678,629
0 		 
 
(5)Jack E Dixon PhDVP/Chief Sci Off retired 6/13 (i)
(ii)		 708,311
0 		0
  		34,313
  		25,000
  		26,130
  		793,754
0 		 
 
(6)Heidi E Henning EsqVP,General Counsel/Sec Eff6/13 (i)
(ii)		 419,210
0 		0
  		12,958
  		25,000
  		21,865
  		479,033
0 		 
 
(7)Mohamoud JibrellVP for Information Technology (i)
(ii)		 275,273
0 		5,000
  		14,809
  		25,000
  		23,164
  		343,246
0 		 
 
(8)Nitin V KotakVP, CFO & Treasurer (i)
(ii)		 369,746
0 		5,000
  		18,593
  		25,000
  		20,050
  		438,389
0 		 
 
(9)Erin K O'Shea PhDVP & Chief Sci Off Eff 7/13 (i)
(ii)		 283,741
0 		0
  		17,101
  		25,000
  		19,852
  		345,694
0 		 
 
(10)Gerald M Rubin PhDVP&Exec Director,Janelia Farm (i)
(ii)		 665,347
0 		0
  		21,879
  		25,000
  		89,231
  		801,457
0 		 
 
(11)Kathy WyszynskiVP, Human Resources (i)
(ii)		 256,817
0 		0
  		7,556
  		25,000
  		9,274
  		298,647
0 		 
 
(12)Landis ZimmermanVP & Chief Investment Officer (i)
(ii)		 855,124
0 		1,013,156
  		19,013
  		25,000
  		23,567
  		1,935,860
0 		 
 
(13)Lauren T Spiliotes EsqDep GenCounsel/Asst SecEff6/13 (i)
(ii)		 270,987
0 		5,000
  		17,627
  		25,000
  		25,682
  		344,296
0 		 
 
(14)Susan S PlotnickAssistant Treasurer (i)
(ii)		 208,929
0 		0
  		17,850
  		21,431
  		22,774
  		270,984
0 		 
 
(15)Monique L MarcusAssistant Controller (i)
(ii)		 173,526
0 		3,000
  		602
  		16,638
  		20,804
  		214,570
0 		 
 
(16)Richard A PenderMan Dir - US Equities (i)
(ii)		 469,613
0 		629,717
  		19,031
  		25,000
  		21,448
  		1,164,809
0 		 
 
(17)Robert J Kolyer JrMan Dir - Diversified Assets (i)
(ii)		 411,151
0 		623,879
  		18,775
  		25,000
  		22,032
  		1,100,837
0 		 
 
(18)Stephen M KitsoulisMan Dir - Fixed Income (i)
(ii)		 356,731
0 		441,799
  		1,450
  		25,000
  		22,989
  		847,969
0 		 
 
(19)Mark A BarnardMan Dir - Private Equities (i)
(ii)		 354,039
0 		439,288
  		19,328
  		25,000
  		22,189
  		859,844
0 		 
 
(20)Thomas R Cech PhDInvestigator (i)
(ii)		 559,471
0 		0
  		24,076
  		25,000
  		23,100
  		631,647
0 		 
 
(21)Avice A MeehanVP Communications (i)
(ii)		 93,913
0 		0
  		269,931
  		11,867
  		2,826
  		378,537
0 		 
 
(22)David A Clayton PhDGroup Leader (i)
(ii)		 108,705
0 		0
  		838
  		10,460
  		21,582
  		141,585
0 		 
 
(23)Matthew R LeeMan Dir - Portfolio Strategies (i)
(ii)		 327,867
0 		370,149
  		17,297
  		25,000
  		22,899
  		763,212
0 		 
 
(24)Anil MadhokMan Dir - Investments & COO (i)
(ii)		 329,031
0 		334,737
  		17,293
  		25,000
  		20,985
  		727,046
0 		 
 
(25)William R Bishai PhDDirector, K-RITH (i)
(ii)		 412,577
0 		0
  		148,159
  		25,000
  		20,586
  		606,322
0 		 
 
(26)Eric R Kandel MDSenior Investigator (i)
(ii)		 525,569
0 		0
  		27,588
  		25,000
  		28,231
  		606,388
0 		 
 
(27)Ryan L MatneyDirector - Diversified Assets (i)
(ii)		 217,960
0 		281,947
  		17,190
  		22,552
  		20,776
  		560,425
0 		 
 
Schedule J (Form 990) 2012

Schedule J (Form 990) 2012
Page 3
Part III
Supplemental Information
Complete this part to provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II.
Also complete this part for any additional information.
Identifier Return Reference Explanation
Part 1 Line 1a   First-class travel: Under HHMI policies, HHMI reimburses its Trustees, President, Vice Presidents, and certain advisory group members for the reasonable cost of airfare at one class above coach for domestic or international flights of three hours or more. If a particular aircraft does not have a business class section, one class above coach may be first class. In this case HHMI would reimburse the traveling Trustee or officer for the reasonable cost of first-class travel if the flight is three hours or more. As an alternative, HHMI may reimburse for the cost of coach airfare plus the cost of an upgrade to travel at one level above coach for a flight of three hours or more. Such travel reimbursements are excluded from taxable compensation in accordance with HHMI's accountable plan. During fiscal year 2013, five officers, six trustees and three key employees flew first class. Housing for personal use: HHMI's President currently resides in an HHMI-owned apartment on the headquarters campus, for which he pays HHMI at a fair market rental rate. Because HHMI's President is also required to spend time at HHMI's Janelia campus, where he runs a research laboratory as well as attends meetings and participates in conferences, HHMI makes a one-bedroom apartment available to him at that location. HHMI's Vice President and Director, Janelia Farm Research Campus is required as a condition of employment to reside on the Janelia campus in housing built for that purpose. HHMI's retired Vice President and Chief Scientific Officer received a mortgage subsidy from HHMI under a Housing Assistance Program for certain individuals who relocate to take positions with HHMI. The Executive Vice President and Chief Operating Officer also received housing assistance from HHMI under this program. In each case, the subsidy is treated as additional taxable compensation. Travel for companions: Under HHMI's moving expense reimbursement policy, if an employee is relocating at HHMI's request, HHMI may reimburse for up to two househunting trips by the relocating employee and members of his or her household. Under this policy, HHMI reimbursed an officer who was relocating at HHMI's request for househunting travel by a companion. The reimbursement was treated as additional taxable compensation. Tax gross-up payments: Under HHMI's moving expense reimbursement policy, if an employee is relocating at HHMI's request, HHMI will ordinarily provide a tax gross-up for the reimbursable moving expenses that must be treated as taxable to the employee. HHMI continued to follow this standard practice during the 2013 fiscal year; including with respect to payments made to one officer. Internationally-assigned employees may receive tax gross-ups in respect of certain tax compliance and personal expenses incurred because of, and during, their overseas assignment. One highly compensated employee received payments pursuant to this standard practice during the 2013 fiscal year, all of which were treated as taxable compensation.
Part I Line 7   HHMI has an incentive compensation plan for its senior investment staff under which a portion of their compensation is determined based on performance of HHMI's portfolio against market benchmarks. HHMI also makes one-time payments to some of its other employees, including but not limited to officers, in recognition of exceptional performance.
Part I Line 8   When recruiting individuals for high-level positions, HHMI typically enters into initial contracts. HHMI has entered into initial contracts with its President and a number of Vice Presidents. HHMI's standard practice is to have independent compensation consultants regularly review and confirm the reasonableness of compensation of HHMI's officers and key employees, regardless of whether the initial contract exception applies.
Schedule J (Form 990) 2012

Additional Data


Software ID:  
Software Version:  
Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990. SchKMediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number
59-0735717
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer 		(i) Pool
financing
Yes No Yes No Yes No
A Loudoun County IDA
  		52-1310230 545910AL5 02-27-2003 500,000,000 FINANCE CONSTRUCTION OF JANELIA FA   X   X   X
B Loudoun Cty IDA
  		52-1310230 545910AP6 10-02-2009 23,000,000 FINANCE CONTRUCTION OF JANELIA FAR   X   X   X
C MEDCO
  		52-1376562 574205FY1 02-15-2008 83,500,000 FINANCE CONSTRUCTION OF HQ EXPANSI   X   X   X
D Medco
  		52-1376562 574205FZ8 05-15-2008 76,500,000 REFUNDING OF ISSUE TO FINANCE HQ C   X   X   X
LOUDOUN COUNTY IDA
  		52-1310230 545910AQ4 05-15-2013 33,130,000 FINANCE CONTRUCTION OF JANELIA FAR   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired . . . . . . . . . . . . . . 0 0 0 0
2 Amount of bonds legally defeased . . . . . . . . . . . 0 0 0 0
3 Total proceeds of issue . . . . . . . . . . . . . . 534,028,000 23,022,042 84,953,297 76,500,000
4 Gross proceeds in reserve funds . . . . . . . . . . . . 0 0 0 0
5 Capitalized interest from proceeds . . . . . . . . . . . 54,203,000 904,914 5,954,687 0
6 Proceeds in refunding escrows . . . . . . . . . . . . 0 0 0 0
7 Issuance costs from proceeds . . . . . . . . . . . . 200,000 0 631,673 0
8 Credit enhancement from proceeds . . . . . . . . . . . 0 0 0 0
9 Working capital expenditures from proceeds . . . . . . . . . 0 43,305 0 0
10 Capital expenditures from proceeds . . . . . . . . . . . 479,625,000 22,073,823 78,366,937 0
11 Other spent proceeds . . . . . . . . . . . . . . 0 0 0 76,500,000
12 Other unspent proceeds . . . . . . . . . . . . . . 0 0 0 0
13 Year of substantial completion . . . . . . . . . . . . 2006 2011 2010 1993
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? . . . . .   X   X   X X  
15 Were the bonds issued as part of an advance refunding issue? . . . . .   X   X   X   X
16 Has the final allocation of proceeds been made? . . . . . . . . X   X   X   X  
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . . X   X   X   X  
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .   X   X   X    
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . .   X   X   X    
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . . X   X   X      
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? . . . . . . . . . . . . . . . . X   X   X      
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . . X     X   X    
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? . X   X   X      
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . . SchKMediumBullet 0.00000% 0.00000% 0.00000% 0%
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . . SchKMediumBullet 0.00000% 0.00000% 0.00000%   %
6 Total of lines 4 and 5 . . . . . . . . . . . . . . . 0.00000% 0.00000% 0.00000%   %
7 Does the bond issue meet the private security or payment test? . . . . .   X   X   X    
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .   X   X   X    
b If “Yes” to line 8a, enter the percentage of bond-financed property sold or disposed of.   %   %   %   %
c If “Yes” to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .   X   X   X    
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2?
  X   X   X    
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T? . . . . . X     X   X X  
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . . X   X     X    
b Exception to rebate? . . . . . . . .   X   X   X    
c No rebate due? . . . . . . . . . .
X       X      
If you checked "No rebate due" in line 2c, provide in Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . . X   X   X   X  
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue? X   X   X   X  
b Name of provider . . . . . . . . . WELLS FARGO
  		JP MORGAN CHASE
  		JP MORGAN
  		 
 
c Term of hedge . . . . . . . . . . 20. 30. 30. 30.
d Was the hedge superintegrated? . . . . . .   X   X   X   X
e Was a hedge terminated? . . . . . . .   X   X   X   X
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .   X   X   X   X
b Name of provider . . . . . . . . . 0
  		0
  		0
  		0
 
c Term of GIC . . . . . . . . . .        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .                
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .   X   X   X   X
7 Has the organization established written procedures to monitor the requirements of section 148? . . .   X   X   X   X
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
1 Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?   X   X   X   X
Part VI
Supplemental Information. Complete this part to provide additional information for responses to questions on Schedule K (see instructions).
Identifier Return Reference Explanation
Schedule K, Part VI 0 PART I The bond issued February 27, 2003 and described in A of this first schedule K also includes CUSIPS 545910AM3, 545910AG6, 545910AH4,545910AJ0, and 545910AK7. PART II, Line 3 The bonds issued in A, B and C of this first schedule K included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV $375 million of the $500 million of swaps pertaining to this bond were integrated in this first schedule K. The other swaps were Bank of America (30 years), Goldman (30 years), JP Morgan (35 years) and JP Morgan Chase (30 years). PART IV, line 2c February 2013. PART IV, Line 3 Yes, In part for this first schedule K.
Schedule K, Part VI 0 PART II, Line 3 The bonds issued in A of this second schedule K included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV, Line 3 Yes, In part for this second schedule K.
Schedule K (Form 990) 2012

Additional Data


Software ID:  
Software Version:  

Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990. SchKMediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number
59-0735717
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer 		(i) Pool
financing
Yes No Yes No Yes No
A Loudoun County IDA
  		52-1310230 545910AL5 02-27-2003 500,000,000 FINANCE CONSTRUCTION OF JANELIA FA   X   X   X
B Loudoun Cty IDA
  		52-1310230 545910AP6 10-02-2009 23,000,000 FINANCE CONTRUCTION OF JANELIA FAR   X   X   X
C MEDCO
  		52-1376562 574205FY1 02-15-2008 83,500,000 FINANCE CONSTRUCTION OF HQ EXPANSI   X   X   X
D Medco
  		52-1376562 574205FZ8 05-15-2008 76,500,000 REFUNDING OF ISSUE TO FINANCE HQ C   X   X   X
LOUDOUN COUNTY IDA
  		52-1310230 545910AQ4 05-15-2013 33,130,000 FINANCE CONTRUCTION OF JANELIA FAR   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired . . . . . . . . . . . . . . 0 0 0 0
2 Amount of bonds legally defeased . . . . . . . . . . . 0 0 0 0
3 Total proceeds of issue . . . . . . . . . . . . . . 534,028,000 23,022,042 84,953,297 76,500,000
4 Gross proceeds in reserve funds . . . . . . . . . . . . 0 0 0 0
5 Capitalized interest from proceeds . . . . . . . . . . . 54,203,000 904,914 5,954,687 0
6 Proceeds in refunding escrows . . . . . . . . . . . . 0 0 0 0
7 Issuance costs from proceeds . . . . . . . . . . . . 200,000 0 631,673 0
8 Credit enhancement from proceeds . . . . . . . . . . . 0 0 0 0
9 Working capital expenditures from proceeds . . . . . . . . . 0 43,305 0 0
10 Capital expenditures from proceeds . . . . . . . . . . . 479,625,000 22,073,823 78,366,937 0
11 Other spent proceeds . . . . . . . . . . . . . . 0 0 0 76,500,000
12 Other unspent proceeds . . . . . . . . . . . . . . 0 0 0 0
13 Year of substantial completion . . . . . . . . . . . . 2006 2011 2010 1993
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? . . . . .   X   X   X X  
15 Were the bonds issued as part of an advance refunding issue? . . . . .   X   X   X   X
16 Has the final allocation of proceeds been made? . . . . . . . . X   X   X   X  
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . . X   X   X   X  
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .   X   X   X    
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . .   X   X   X    
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . . X   X   X      
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? . . . . . . . . . . . . . . . . X   X   X      
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . . X     X   X    
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? . X   X   X      
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . . SchKMediumBullet 0.00000% 0.00000% 0.00000% 0%
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . . SchKMediumBullet 0.00000% 0.00000% 0.00000%   %
6 Total of lines 4 and 5 . . . . . . . . . . . . . . . 0.00000% 0.00000% 0.00000%   %
7 Does the bond issue meet the private security or payment test? . . . . .   X   X   X    
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .   X   X   X    
b If “Yes” to line 8a, enter the percentage of bond-financed property sold or disposed of.   %   %   %   %
c If “Yes” to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .   X   X   X    
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2?
  X   X   X    
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T? . . . . . X     X   X X  
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . . X   X     X    
b Exception to rebate? . . . . . . . .   X   X   X    
c No rebate due? . . . . . . . . . .
X       X      
If you checked "No rebate due" in line 2c, provide in Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . . X   X   X   X  
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue? X   X   X   X  
b Name of provider . . . . . . . . . WELLS FARGO
  		JP MORGAN CHASE
  		JP MORGAN
  		 
 
c Term of hedge . . . . . . . . . . 20. 30. 30. 30.
d Was the hedge superintegrated? . . . . . .   X   X   X   X
e Was a hedge terminated? . . . . . . .   X   X   X   X
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .   X   X   X   X
b Name of provider . . . . . . . . . 0
  		0
  		0
  		0
 
c Term of GIC . . . . . . . . . .        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .                
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .   X   X   X   X
7 Has the organization established written procedures to monitor the requirements of section 148? . . .   X   X   X   X
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
1 Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?   X   X   X   X
Part VI
Supplemental Information. Complete this part to provide additional information for responses to questions on Schedule K (see instructions).
Identifier Return Reference Explanation
Schedule K, Part VI 0 PART I The bond issued February 27, 2003 and described in A of this first schedule K also includes CUSIPS 545910AM3, 545910AG6, 545910AH4,545910AJ0, and 545910AK7. PART II, Line 3 The bonds issued in A, B and C of this first schedule K included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV $375 million of the $500 million of swaps pertaining to this bond were integrated in this first schedule K. The other swaps were Bank of America (30 years), Goldman (30 years), JP Morgan (35 years) and JP Morgan Chase (30 years). PART IV, line 2c February 2013. PART IV, Line 3 Yes, In part for this first schedule K.
Schedule K, Part VI 0 PART II, Line 3 The bonds issued in A of this second schedule K included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV, Line 3 Yes, In part for this second schedule K.
Schedule K (Form 990) 2012

Additional Data


Software ID:  
Software Version:  

Schedule L
(Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Transactions with Interested Persons
MediumBullet Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet Attach to Form 990 or Form 990-EZ. MediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Excess Benefit Transactions (section 501(c)(3) and section 501(c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1(a) Name of disqualified person (b) Relationship between disqualified person and organization (c) Description of transaction (d) Corrected?
Yes No





2
Enter the amount of tax incurred by organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image$
 
3
Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image$
 

Part II
Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22
(a) Name of interested person (b) Relationship with organization (c) Purpose of loan (d) Loan to or from the organization? (e)Original principal amount (f)Balance due (g) In default? (h) Approved by board or committee? (i)Written agreement?
To From Yes No Yes No Yes No
Total ......Small Bullet $  
Part III
Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of assistance (d) Type of assistance (e) Purpose of assistance
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 50056A
Schedule L (Form 990 or 990-EZ) 2012
Schedule L (Form 990 or 990-EZ) 2012
Page 2
Part IV
Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of transaction (d) Description of transaction (e) Sharing of organization's revenues?
Yes No
(1) American Express Company Shared Trustee/Director 384,853 see Supplemental Information   No
(2) Bank of America Corporation Shared Trustee/Director 1,615,459 see Supplemental Information   No
Part V
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule L (see instructions).
Identifier Return Reference Explanation
Reportable Business Transactions Part IV, Line d A trustee of HHMI is also a director of American Express Company. HHMI paid American Express Company for travel and related services provided to HHMI in the ordinary course of business. A trustee of HHMI is also a director of Bank of America Corporation. HHMI paid Bank of America for banking and related services provided to HHMI in the ordinary course of business.
Schedule L (Form 990 or 990-EZ) 2012

Additional Data


Software ID:  
Software Version:  




SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Identifier Return Reference Explanation
Authority over Financial Account in a Foreign Country Core Form, Part V, Line 4b HHMI has signature authority over investment accounts in the following foreign countries through their custodian, Bank of New York Mellon: ARGENTINA AUSTRALIA AUSTRIA BELGIUM BERMUDA BRAZIL CANADA CHILE CHINA COLOMBIA CZECH REPUBLIC DENMARK EGYPT ESTONIA FINLAND FRANCE GERMANY GREECE HONG KONG HUNGARY INDIA INDONESIA IRELAND ISRAEL ITALY JAPAN JORDAN KENYA MALAYSIA MAURITIUS MEXICO MOROCCO NETHERLANDS NEW ZEALAND NIGERIA NORWAY PERU PHILIPPINES POLAND PORTUGAL ROMANIA RUSSIA SINGAPORE SLOVENIA SOUTH AFRICA SOUTH KOREA SPAIN SRI LANKA SWEDEN SWITZERLAND TAIWAN THAILAND TURKEY UKRAINE UNITED KINGDOM URUGUAY VENEZUELA ZIMBABWE. HHMI also has direct signature authority in Mauritius.
Description of 990 Review Process Core Form, Part VI, Section B, Line 11A The Howard Hughes Medical Institute's Form 990 is initially prepared by its Tax Compliance Department, in coordination with other HHMI departments as needed. The draft return is reviewed by senior management of HHMI and by attorneys in HHMI's Office of the General Counsel. Following these reviews and the resolution of any questions that have been raised, the draft return is reviewed by HHMI's outside tax preparer. Finally, a copy of the return is provided to the members of HHMI's Board of Trustees so that they have an opportunity to review and comment on the return before it is filed.
Conflict of Interest Policy Core Form, Part VI, Section B, Line 12a-12c In addition to HHMI's code of conduct, which addresses conflicts of interest and applies to all HHMI employees, officers, Trustees, and advisors, HHMI has specific conflict of interest policies for different categories of personnel. Under the HHMI policies that apply to Trustees, officers, and key employees, these individuals must disclose annually interests that could give rise to conflicts of interest, and must certify annually their compliance with the conflict of interest policy that applies to them. Annual disclosures and certifications are reviewed by HHMI's Office of the General Counsel, and by other HHMI managers as needed. The conflict of interest policy covering HHMI's Trustees also requires each Trustee to disclose to the other Trustees any actual or apparent conflict of interest with respect to a proposed HHMI transaction. If the other Trustees decide that there is only the appearance of a conflict of interest, and that it could not reasonably be considered to affect the independent, unbiased judgment of the disclosing Trustee with respect to the transaction at issue, no further action is required to address the apparent conflict. In all other cases, including all actual conflicts of interest, the disclosing Trustee is not permitted to participate in the deliberation or decision regarding the transaction under consideration, and must leave the room during the deliberation and vote. The conflict of interest policy covering HHMI's officers and key employees requires each covered individual to obtain supervisory approval up to the level of HHMI's President before entering into an affiliation with or acquiring an interest of 1% or more in any entity that is or may become a recipient of HHMI funds. HHMI's President, in consultation with HHMI's General Counsel, may permit the affiliation or interest if it would not interfere with the covered individual's performance of his or her HHMI responsibilities, would not create the appearance of a conflict of interest, and would be consistent with sound business judgment. HHMI's President may set conditions on approval, for example that there be no remuneration to the covered individual. Proposed affiliations and interests of 1% or more of HHMI's President are subject to the approval of the Chairman of the Trustees.
Process for determining compensation Core Form, Part VI, Section B, Lines 15a-b The compensation for HHMI's President, other officers, and key employees is set using the following procedures. Every other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent compensation consultants to conduct a study of comparable market data. The study includes data for HHMI's President, other officers, and key employees. The independent compensation consultants also provide an opinion regarding the reasonableness of the compensation arrangements for the positions included in the study. The study includes comparable market data for all components of compensation for each person covered by the study, including base salary, incentive compensation (if any), and benefits. The Committee relies on the market data and opinion provided by the compensation consultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers and key employees. The decision is made by independent Trustees. Any Trustee who has a conflict of interest with respect to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, and leave the meeting room during the debate and voting on it. In the alternate years when a study is not done, the Audit and Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit increases for HHMI employees, including senior management, is reasonable compared with generally prevailing compensation increases in the market over the past year. The Committee relies on this advice in recommending compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in making compensation decisions. Recusal procedures are the same in as in the years when a study is done. In each year, minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for approval at the next meeting. Approved minutes are kept in HHMI's records. All minutes include the date of the meeting, identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees with a conflict of interest. The comparability studies and opinions relied on at the meeting are referenced in the minutes, and copies of these materials are also kept in HHMI's records. HHMI's Board of Trustees followed this process in August 2013 in determining compensation for the following positions: President; Vice Presidents; and Managing Directors - Investments.
Governing documents etc available to the public Core Form, Part VI, Section C, Line 19 HHMI's practice has been to make a copy of its charter and by-laws available on request. HHMI's code of conduct, which addresses conflicts of interest, is available to the public on the HHMI web site. A downloadable copy of HHMI's most recent audited financial statements is also available to the public on the web site. In addition, HHMI publishes "Year in Review" that provides a summary of each year's activity, expenditures, and financial performance; this publication is distributed in print and is posted on the HHMI web site.
Statement 1 Part III, Program Service, line 4a - Medical Research 4A: Medical Research (A) The HHMI Investigator Program (B) Janelia Farm Research Campus (C) Highlights from HHMI Research Laboratories (Fiscal Year 2013) (D) Honors and Awards Received by HHMI Scientists (A) The HHMI Investigator Program The Howard Hughes Medical Institute's approach to biomedical research can be summarized in three words: people, not projects. By appointing scientists as HHMI investigators - rather than awarding research grants - the Institute provides long-term, flexible funding that enables its researchers to pursue their scientific interests wherever they lead. HHMI believes that scientists of exceptional talent and imagination will make fundamental discoveries of lasting scientific value and benefit to humanity if they are given the resources, time, and freedom to pursue challenging questions. The Institute nurtures the creativity and intellectual daring of scientists who are willing to set aside conventional wisdom or the "easy" question for a fundamental problem that may take many years to solve. Among the characteristics that distinguish this group of scientists are qualities such as creativity, a penchant for risk-taking, and a commitment to discovery, productivity, and perseverance. This unique research model is an imaginative and powerful alternative to funding biomedical research through grants. The HHMI Investigator Program employs more than 313 HHMI researchers, among them 15 Nobel laureates and 172 members of the National Academy of Sciences. In the last decade, HHMI investigators have won 9 Nobel Prizes. These exceptional scientists direct Institute research laboratories on the campuses of 70 universities and other research organizations throughout the United States. Since the early 1990s, investigators have been selected through rigorous national competitions. The Institute solicits applications directly from scientists at medical schools and other research institutions in the United States, with the aim of identifying those who have the potential to make significant contributions to science. HHMI employs an open application process to ensure that it is selecting its researchers from a broad and deep pool of scientific talent. In 2013, HHMI announced the selection of 27 new HHMI investigators through a national open competition. The competition was open to eligible applicants in 2012 and HHMI selected and announced the finalists in 2013. The initiative represents an additional, total investment of approximately $150 million in basic biomedical research by the Institute over the next five years. The scientists selected as HHMI investigators represent 19 institutions from across the United States, including one-the Scripps Research Institute in La Jolla, California-that is adding an HHMI investigator for the first time. The new group of HHMI investigators-which includes 10 current HHMI Early Career Scientists-was selected for their individual scientific excellence from a group of 1,155 applicants. Once selected, HHMI investigators continue to be based at their home institutions, typically leading a research group of 10-25 students, postdoctoral associates and technicians, but they become Institute employees and are supported by HHMI field staff throughout the country. With freedom and flexibility come high expectations for intellectual output. HHMI demands creativity and innovation. Investigators are expected to work at the frontiers of their chosen field, to ask fundamental questions, and to take risks. HHMI prizes impact over publication volume in its merit-based renewal of investigator appointments and recognizes that some areas of research will proceed more slowly than others. The renewal of an investigator's five-year appointment is dependent on a rigorous peer-review process that centers on an evaluation of the originality and creativity of the investigator's work relative to others in the field, as well as the investigator's plan for future research. Those investigators whose appointments are not renewed remain HHMI employees for multi-year phase-out periods to facilitate their ability to obtain other funding for their research. In this fiscal year, HHMI also supported six teams of scientists with wide-ranging expertise who are coming together to solve challenging problems with the aid of new Howard Hughes Medical Institute Collaborative Innovation Awards (HCIA). HHMI will invest $40 million over the next four years to enable the teams to carry out potentially transformative research. Together, the teams-each headed by an HHMI investigator-include 28 researchers from 20 institutions in the United States, Germany, and Israel. Each collaborator will receive funds from HHMI to cover their research budget for the HCIA project, and the flexibility to pursue their best ideas. Highlights of research conducted, and awards received, by HHMI scientists during its year ended August 31, 2013 are included below. B) Janelia Farm Research Campus The Janelia Farm Research Campus offers a collaborative research environment for scientists across an array of disciplines who have focused on two broad scientific areas of scientific inquiry: the identification of general principles governing how neuronal circuits process information and development of imaging technologies and computational methods that support image analysis. In the current fiscal year, there were 53 laboratory heads at Janelia, in addition to supporting graduate students and other scientific trainees, visiting scientists, and a vibrant scientific conference program. During this fiscal year, Janelia recruited two new lab heads: Barry Dickson and Nikolaus Grigorieff. Dickson, who was most recently at the Institute for Molecular Pathology in Vienna, Austria, and Grigorieff, who was an HHMI investigator at Brandeis University, bring additional expertise in neuroscience and imaging to the Virginia campus. Dickson, a neuroscientist, wants to understand how circuits in the brain guide innate behavior. His studies of fruit fly mating behavior are helping to uncover how the brain processes information and makes decisions. Grigorieff develops and uses advanced microscopy techniques to visualize the three-dimensional structure of large macromolecular complexes, with the goal of learning how their components function and interact with one another. (C) Highlights from HHMI Research Laboratories (Fiscal Year 2013) (1) The Circuitry of Uncertainty Alla Y. Karpova, Janelia Farm Research Campus http://www.hhmi.org/news/circuitry-uncertainty Neuroscientists have long been interested in adaptability, particularly in the moment when an individual discards an old belief and begins to formulate a new one. Alla Karpova, a lab head at HHMI's Janelia Farm Research Campus, is studying what goes on in the brain when this happens. In rats, Karpova and her colleagues found that the rejection of an old belief correlates with abrupt changes in activity in the medial prefrontal cortex, a brain region involved in cognitive functions such as reward anticipation and decision-making. (2) Genome-Wide Methylation Map of Disease-Causing E. coli Reveals Surprises Matthew K. Waldor, Brigham and Women's Hospital http://www.hhmi.org/news/genome-wide-methylation-map-disease-causing-e-col i-reveals-surprises A new DNA sequencing technique has enabled HHMI researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium. By comparing these patterns between related strains of the bacteria, they identified a way that viruses that infect bacteria (known as bacteriophages) can dramatically alter their host. (3) New Software Speeds Analysis of Animal Behavior Kristin M. Branson, Janelia Farm Research Campus http://www.hhmi.org/news/new-software-speeds-analysis-animal-behavior Using new software developed at HHMI's Janelia Farm Research Campus, a computer can be trained to recognize characteristic animal behaviors like an experienced biologist. Rather than scrutinizing hours of video to catalog how often fruit flies chase one another, for example, scientists can quickly teach the software what to look for, and let it convert the video into useful statistics.
Statement 1-continued Part III, Program Service, line 4a - Medical Research (C) Highlights from HHMI Research Laboratories (Fiscal Year 2013) continued (4) Scientists Discover Cellular Mechanism that Triggers Immune Responses to DNA Zhijian Chen, University of Texas Southwestern Medical Center http://www.hhmi.org/news/scientists-discover-cellular-mechanism-triggers-i mmune-responses-dna Free-floating pieces of DNA in a cell's watery interior can mean bad things: invading viruses, bacteria, or parasites, ruptured cellular membranes, or disease. Genetic material is meant to be contained in a cell's nucleus or key organelles, and when it's loose, it's a sign for the immune system that something is wrong. HHMI scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell's nucleus in the cytosol and setting off the resulting immune reaction. The findings could lead to treatments for autoimmune diseases such as lupus, in which ongoing immune reactions are often set off by loose pieces of DNA. (5) Learning How Cells Tune In to Important Information Erin K. O'Shea, Harvard University http://www.hhmi.org/news/learning-how-cells-tune-important-information Every minute of its existence, a living cell must assess and analyze myriad bits of information-everything from the temperature of its environment to the chemical makeup of its surroundings. Sometimes, these inputs cause a cell to change how it functions, but other times, the information may not lead to a measurable change in the cell's activity. HHMI researchers have discovered how a single molecule in a cell can tune its response to different strengths of an input, an important advance in understanding how a whole cell varies its behavior in different situations. (6) Axons Contain a Periodic and Ringed Cytoskeleton Xiaowei Zhuang, Harvard University http://www.hhmi.org/news/scientists-discover-periodic-and-ringed-cytoskele ton-within-axons The plasma membranes that give cells their shapes are typically upheld by linear meshworks of the protein actin. In contrast, HHMI scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells. The actin structures loop around axons at perfect intervals, which are connected by an associated cytoskeletal protein, spectrin. The researchers suggest that these periodically distributed actin rings, connected by flexible spectrin tetramers, lend a flexible yet robust support for the skinny nerve fibers. (7) A New View of Transcription Initiation Eva Nogales, University of California, Berkeley http://www.hhmi.org/news/new-view-transcription-initiation The human genome is contained within a vast jumble of DNA. Its 20,000 or so genes are concealed within strings of As, Ts, Gs, and Cs, and each gene must be turned on at the right time and in the right cells. For the first time, HHMI scientists have glimpsed the cellular machinery that accomplishes that feat, as it assembles directly on the DNA and readies it for transcription into RNA, the first step in protein production. (8) Wnt Signal Regulates the Geometry of Dividing Stem Cells Roel Nusse, Stanford University http://www.hhmi.org/news/wnt-signal-regulates-geometry-dividing-stem-cells For organisms to develop and grow, asymmetry is essential. New research from HHMI scientists reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells-one identical to its parent, the other a more specialized cell type-and aligns those cells. In a developing tissue, such oriented divisions will position cells to migrate to the right place to ensure the right architecture. (9) Seeing the Brain's Circuits with a New CLARITY Karl Deisseroth, Stanford University http://www.hhmi.org/news/seeing-brains-circuits-new-clarity For scientists working to uncover the mysteries of the brain, fat is a problem. The fats inside cells bend and scatter light, obscuring researchers' views when they try to peer deep into tissue. A new technique developed by HHMI scientists solves that problem by removing the fat from the brain and supporting the remaining brain structures in a hydrogel-literally giving scientists a clear view of an intact brain. The technique, called CLARITY, transforms biological tissue into an optically transparent sample that retains its original structure and molecular information. (10) Spontaneous Mutations May Play Role in Congenital Heart Disease Richard P. Lifton, Yale University Christine E. Seidman, Brigham and Women's Hospital http://www.hhmi.org/news/spontaneous-mutations-play-key-role-congenital-he art-disease Every year, thousands of babies are born with severely malformed hearts, disorders known collectively as congenital heart disease. Many of these defects can be repaired though surgery, but researchers don't understand what causes them or how to prevent them. New research from HHMI labs shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children. Although genetic factors contribute to congenital heart disease, many children born with heart defects have healthy parents and siblings, suggesting that new mutations that arise spontaneously-known as de novo mutations-might contribute to the disease. (11) Genetic Engineering Alters Mosquitoes' Sense of Smell Leslie Vosshall, The Rockefeller University http://www.hhmi.org/news/genetic-engineering-alters-mosquitoes-sense-smell In one of the first successful attempts at genetically engineering mosquitoes, HHMI researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET. The research not only demonstrates that mosquitoes can be genetically altered using the latest research techniques, but paves the way to understanding why the insect is so attracted to humans, and how to block that attraction. (12) Newly Identified Gene Protects Wheat Plants from Infection Jorge Dubcovsky, University of California, Davis http://www.hhmi.org/news/newly-identified-gene-protects-wheat-plants-devas tating-infection HHMI scientists have identified a gene that enables wheat crops to fight off stem rust, a dreaded fungus that blights wheat fields with rusty brown lesions and reduces yields. The researchers worked for five years to identify the resistance gene in a species of wild wheat. Stem rust has long been the wheat farmer's adversary. The spores erupt from brownish lesions on infected plants' stems and drift from field to field on the wind. The most recent U.S. outbreak occurred in the 1950s, when stem rust wiped out 40 percent of the spring wheat harvest. Scientists beat back the fungus by breeding wheat containing a few effective resistance genes. (13) Ultrasensitive Calcium Sensors Shine New Light on Activity of Neurons Karel Svoboda, Loren Looger, and Vivek Jayaraman, Janelia Farm Research Campus http://www.hhmi.org/news/ultrasensitive-calcium-sensors-shine-new-light-ne uron-activity When a neuron receives a signal from one of its neighbors, the impulse sets off a sudden series of electrochemical events geared toward passing the message along. Among the first events: calcium ions rush into the neurons when a set of channels opens. Scientists at HHMI's Janelia Farm Research Campus have engineered a new protein that brightly fluoresces each time it senses these calcium waves, giving the scientists a way to visualize the activity of every neuron throughout the brain. The new protein is the most sensitive calcium sensor ever developed and the first to allow the detection of every neural impulse, rather than just a portion. (14) A New Wrinkle in Parkinson's Disease Research Kevan Shokat, University of California, San Francisco http://www.hhmi.org/news/new-wrinkle-parkinsons-disease-research The active ingredient in an over-the-counter skin cream might do more than prevent wrinkles. HHMI scientists have discovered that the drug, called kinetin, also slows or stops the effects of Parkinson's disease on brain cells. They identified the link through biochemical and cellular studies, but the research team is now testing the drug in animal models of Parkinson's.
Statement 1-continued 2 Part III, Program Service, line 4a - Medical Research (D) Honors and Awards Received by HHMI Scientists (Fiscal Year 2013) (1) Lefkowitz Awarded Nobel Prize in Chemistry The Royal Swedish Academy of Sciences honored Robert J. Lefkowitz, a Howard Hughes Medical Institute (HHMI) investigator at Duke University, and Brian K. Kobilka of Stanford University School of Medicine with the 2012 Nobel Prize in Chemistry for studies of G-protein coupled receptors. The Nobel Prize in Chemistry was awarded for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled receptors. (2) Vale Wins Lasker Award The Albert and Mary Lasker Foundation announced that HHMI investigator Ronald D. Vale of the University of California, San Francisco, Michael Sheetz of Columbia University and James Spudich of Stanford University School of Medicine will share the 2012 Albert Lasker Basic Medical Research Award. The Lasker Awards-considered among the most respected science prizes in the world-honor visionaries whose insight and perseverance have led to dramatic advances that will prevent disease and prolong life. Vale, Sheetz and Spudich were honored for their discoveries concerning cytoskeletal motor proteins-machines that move cargoes within cells, contract muscles, and enable cell movements. (3) Two Janelia Scientists Elected as AAAS Fellows Ulrike Heberlein and Nelson Spruston of HHMI's Janelia Farm Research Campus were elected Fellows of the American Association for the Advancement of Science (AAAS). Election as a AAAS Fellow is an honor bestowed upon members by their peers. Fellows are recognized for meritorious efforts to advance science or its applications. Heberlein was recognized in the AAAS Section of Biological Sciences, while Spruston was recognized in the Section of Neuroscience. (4) HHMI Trio Honored with Breakthrough Prizes Three HHMI investigators were among 11 scientists recognized with the inaugural Breakthrough Prize in Life Sciences. HHMI investigators Cornelia I. Bargmann at the Rockefeller University, Charles L. Sawyers at Memorial Sloan-Kettering Cancer Center and Bert Vogelstein at Johns Hopkins University School of Medicine were honored for excellence in research aimed at curing intractable diseases and extending human life. The prizes are administered by the Breakthrough Prize in Life Sciences Foundation, a not-for-profit corporation dedicated to advancing breakthrough research. Each prize carries an award of $3 million. (5) Elledge Receives 2013 Canada Gairdner International Award The Gairdner Foundation named Howard Hughes Medical Institute (HHMI) researcher Stephen Elledge a recipient of a prestigious 2013 Canada Gairdner International Award in recognition of his contributions to medical science. The awards, which are presented annually, recognize scientists responsible for some of the world's most significant medical discoveries. Elledge, who became an HHMI investigator in 1993, was honored for elucidation of the DNA damage response as a signaling network that controls DNA repair and genomic stability. The Foundation noted that Elledge's research is likely to have profound implications for cancer and other diseases. Elledge is on the faculty at Harvard Medical School. (6) HHMI Scientists Elected to National Academy of Sciences Seven HHMI investigators, two HHMI-Gordon and Betty Moore Foundation investigators, two HHMI professors and a senior fellow at Janelia Farm Research Campus have been elected to the National Academy of Sciences. The National Academy of Sciences is a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. The scientists are Kristi S. Anseth, University of Colorado, Boulder; Ronald R. Breaker, Yale University; Xuemei Chen, University of California, Riverside; Janelia Senior Fellow Winfried Denk, Max Planck Institute for Medical Research; Edward M. DeRobertis, University of California, Los Angeles; Jorge Dubcovsky, University of California, Davis; William R. Jacobs, Jr., Albert Einstein College of Medicine; Beth Levine, University of Texas Southwestern Medical Center; HHMI Professor Mary Lidstrom, University of Washington; Norbert Perrimon, Harvard Medical School; Stephen R. Quake, Stanford University; HHMI Professor Graham Walker, MIT. (7) Six HHMI Researchers Elected to Institute of Medicine Six Howard Hughes Medical Institute (HHMI) investigators were elected to the Institute of Medicine (IOM) of the National Academies. The Institute of Medicine was established in 1970 by the National Academy of Sciences to honor professional achievement in the health sciences and to serve as a national resource for independent, scientifically informed analysis and recommendations on health issues. The scientists are Gideon Dreyfuss, University of Pennsylvania; Joseph G. Gleeson, University of California, San Diego; Brendan Lee, Baylor College of Medicine; Ruslan M. Medzhitov, Yale University; Danny Reinberg, New York University; and Christopher A. Walsh, Boston Children's Hospital.
Statement 2 Part III, Program Service, line 4b - Science Education Programs 4b: Science Education Programs (A) Graduate Science Education and Medical Research Training (B) Precollege and Undergraduate Science Education Program (C) Educational Resources (D) Tangled Bank Studios (E) eLife - Open Access Journal HHMI's Department of Science Education emphasizes initiatives with the power to transform graduate, undergraduate, and precollege education in the sciences. HHMI is the largest private funder of science education in the United States. During the its fiscal year ended August 31, 2013, the Institute distributed $80 million in grants to support science education. The Institute's science education programs support ties between scientific research and teaching with the goal of increasing and enhancing student research opportunities; improving science courses, curricula, and instruction; and providing enhanced graduate and physician scientist training opportunities. Most HHMI grants are awarded through competitions with specific objectives and eligibility criteria and awards are generally made following a stringent process of peer review. HHMI does not encourage and rarely funds unsolicited grant proposals. HHMI's educational activities are funded through three major programs; the goals of each program and the major activities for the year are summarized below. (A) Graduate Science Education and Medical Research Training This program focuses on the development of innovative graduate education programs through grants to institutions and fellowships to students. It supports research fellowships for medical students, doctoral fellowships for students who are disadvantaged or from groups underrepresented in the sciences, doctoral fellowships for international students pursuing Ph.D. at U.S. institutions, and awards research grants to physician-scientists at the outset of their careers as independent scientists. Sixty-nine medical, dental, and veterinary students were selected to participate in the Medical Research Fellows Program. The fellowships enable students to take a year off from professional school to conduct laboratory research. The hope is that these students will one day choose to work at the crossroads of basic and clinical research. To expand the program, HHMI has entered into partnerships with several foundations that fund students who have specific research interests. A total of seven medical research fellows will be funded by HHMI's six partner organizations this year: The Burroughs Wellcome Fund (BWF), the Duchenne Research Fund (DRF), the Foundation Fighting Blindness (FFB), the Society of Interventional Radiology Foundation (SIRF), Citizens United for Research in Epilepsy (CURE), and K-RITH. Sixty-two awardees will be supported by HHMI. Nine promising students were selected as recipients of HHMI's Gilliam Fellowships for Advanced Study. The fellowships provide full support for up to four years of study toward a Ph.D. in the sciences to students who are disadvantaged or who come from groups underrepresented in the sciences. The Gilliam Fellows Program, which is now in its tenth year, aims to enrich science research and increase the diversity of college and university faculty members by supporting the education of top student scientists who will themselves either become professors or are committed to creating a more diverse academic community. Fellowship recipients previously participated in HHMI's Exceptional Research Opportunities Program (EXROP), which provides summer research experiences in HHMI laboratories. HHMI also selected 42 exceptionally promising graduate students from 19 countries to receive International Student Research Fellowships. This support will enable these individuals to devote their full attention to research during their third, fourth, and fifth year of graduate school. HHMI began this program because it recognized that international students in U.S. graduate schools often have difficulty getting funding to support their studies. The fellowships are designed to fund the students' graduate education at a pivotal point in their scientific careers when they delve into intense laboratory research for their doctoral dissertations. (B) Precollege and Undergraduate Science Education Program Through this program, HHMI seeks to recruit and develop the future leaders of science and science education, and enhance science literacy among all students. Precollege grants support teacher training and inquiry-based student learning. Grants to colleges and universities support undergraduate student research, faculty and curriculum development, and science education outreach activities. Through the HHMI Professors Program, HHMI provides support to distinguished scientists with a commitment to teaching. In the 2013 fiscal year: HHMI announced it would fund up to 15 new HHMI professors awards, which will be made in 2014. Each scientist selected will receive $1 million over five years to create activities that integrate their research with student learning in ways that enhance undergraduate students' understanding of science. Applications for the new awards were due in this fiscal year. HHMI professors are accomplished research scientists who are deeply committed to making science more engaging for undergraduates. By providing them with the funds and support to implement their ideas, HHMI hopes to empower these individuals to create new models for teaching science at research universities. HHMI also announced it would invest $22.5 million over five years to help major research universities train a new generation of science and mathematics teachers. The grant from HHMI will allow the National Math and Science Initiative (NMSI) to expand its highly regarded UTeach Program to 10 major research universities in the United States. NMSI invited eligible schools to apply for these grants and will select the finalists in late 2013. HHMI invited 203 research universities to apply for a new round of science education grants aimed at helping research universities improve persistence of students studying STEM disciplines and reinvigorating introductory science courses. The Institute expects to make up to 35 awards of up to $2.5 million each. It will announce the recipients in late spring 2014. A total of 76 college students were selected to participate in HHMI's Exceptional Research Opportunities Program (EXROP). In addition, 23 students from the 2012 EXROP program were funded to return to their 2012 labs for a second summer research experience. The EXROP program provides summer research experiences in the labs of HHMI investigators, professors, and at the Janelia Farm Research Campus. Now in its eleventh year, the EXROP program is designed to encourage the students to pursue careers in science. (C) Educational Resources This program produces science education materials that feature cutting-edge research conducted by HHMI investigators and other scientists. The materials are designed primarily for high school and undergraduate science educators, but they also find an audience among the general public. The 2013 Holiday Lectures on Science "Medicine in the Genomics Era," featured HHMI investigators Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center and Christopher A. Walsh of Boston Children's Hospital. They discussed the breathtaking pace of discoveries into the genetic causes of various types of cancers and diseases of the nervous system, and the impact of those discoveries on our understanding of normal human development and disease, before a live audience of nearly 200 high school students from the Washington, DC area and a national and international audience who could view the lectures through the HHMI website. The lectures will later be available online and by the distribution of free DVDs and supported by a variety of accompanying online teaching materials. Each year, more than 100,000 copies of the DVDs are distributed; the supporting website receives more than two million visits each year.
Statement 2-continued Part III, Program Service, line 4b - Science Education Programs (C) Educational Resources (continued) At the National Association of Biology Teachers (NABT) annual meeting, HHMI premiered four new short documentary films. Three of the films are part of the new The Origin of Species series. First in the series, The Making of a Theory chronicles the epic voyages of Darwin and Wallace and how they independently discovered the natural origin of species and formulated the theory of evolution by natural selection. The Beak of the Finch follows four decades of research by Princeton University biologists Peter and Rosemary Grant on finch species that live only on the Galpagos Islands-research that illuminates how species form and multiply. The third film in the series, Lizards in an Evolutionary Tree, takes viewers to the islands of the Caribbean where Harvard University biologist Jonathan Losos is studying how adaptation to a variety of habitats has led to the evolution of dozens of species of anole lizards. The other film that premiered at NABT is The Double Helix, a fresh look at the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. The film combines rarely seen archival footage with interviews with some of today's leading scientists to bring this landmark discovery and all of its implications to life. The Double Helix was also shown to the students attending the 2013 Holiday Lectures on Science. The film screening was followed by a panel discussion that included Nobel laureate James Watson and other scientists featured in the film. The Holiday Lectures and short science films are all available on the BioInteractive website, www.hhmi.org/biointeractive. The Educational Resources Group also developed EarthViewer, a free, interactive app designed for iPad and Android devices, that lets users explore Earth's history with the touch of a finger by scrolling through 4.5 billion years of geological evolution. The app tracks the planet's continental shifts, compares changes in climate as far back as the planet's origin, and explores Earth's biodiversity over the last 540 million years. It combines visual analysis with hard data, and helps students make connections between geological and biological change. (D) Tangled Bank Studios Tangled Bank Studios, LLC, HHMI's documentary film production unit, is dedicated to the creation of original science documentaries for broadcast, theatrical, and digital distribution. As an extension of HHMI's longstanding science education mission, the company aims to produce programs that capture compelling stories of discovery across all branches of scientific inquiry. Tangled Bank's inaugural slate of productions includes: Your Inner Fish, a scientific adventure story based on the best-selling book by paleontologist and anatomist Neil Shubin, Ph.D., of the University of Chicago. It takes us from Kenya to the Arctic Circle to uncover the 3.5-billion-year history of the human body-and how our ancient ancestors have shaped our anatomy. This three-part series is being produced in collaboration with U.K. production company Windfall Films. Your Inner Fish will air on PBS on April 9, 16 & 23, 2014, as part of the network's themed science nights. The Quest to Map the World, a three-part series that tells the epic story of the scientists and explorers who risked their lives to map the planet and, in the process, changed our understanding of the world we inhabit. The series is a co-production with National Geographic Television, slated to air on PBS in fall 2014. A program, tentatively titled Jabbed, will look at the science of vaccines against the background of resistance to immunization on the part of some parents, and the consequent return of diseases such as pertussis, measles and pneumococcal pneumonia. The program examines the history of vaccination, how vaccines work to create immunity and why vaccine skepticism is on the rise in the US and abroad. The film is produced in collaboration with Genepool Productions' Sonya Pemberton, who won the 2012 Emmy Award for best science film for her documentary on telomeres. Jabbed is expected to air on PBS/NOVA. Extinction: To the Brink and Back, based on the classroom film by the Education Resources group, takes a broader look at the science of extinction and the possibility that the planet is facing a sixth extinction. New material includes a detailed section on the Permian extinction with recent science confirming its volcanic causes, and a look at the problems besetting Yellowstone. The film will air on the Smithsonian Channel. US home video distribution is being undertaken in partnership with PBSd. Off the Fence, an independent distribution company based in Amsterdam, will distribute the films internationally. (E) eLife - Open Access Journal HHMI, the Max Planck Society, and the Wellcome Trust have supported the establishment of a top tier scientific journal called eLife. The online journal follows an open access model and is directed by practicing scientists. eLife Sciences Publications, Ltd., is an independent non-profit entity governed by a separate board of directors. eLife began publishing research articles in late 2012 and is now publishing articles online on a regular basis. Additional information about eLife can be found at www.elifesciences.org.
Statement 3 PART III, Program Service, Line 4c - Support for International Science 4C: Support for International Science (A)International Early Career Scientist Program (B)Senior International Research Scholars Program (C)The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) (A) International Early Career Scientist Program In 2012, HHMI began the International Early Career Scientist Program, which awards each selected scientist $650,000 over a period of five years with the goal of helping these talented individuals establish independent research programs. In this pilot program, HHMI identified scientists who are, or have the potential to become, scientific leaders. The 28 HHMI International Early Career scientists are at 22 institutions in 12 countries. Each scientist who was selected had directed his or her own laboratory for less than seven years when they applied to HHMI. The countries represented by the HHMI International Early Career scientists are Argentina, Brazil, Chile, China, Hungary, India, Italy, Poland, Portugal, South Africa, Spain, and South Korea. (B) Senior International Research Scholars Program HHMI selected 13 of the world's leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences. The new SIRS awardees, selected from a group of previous HHMI international research scholars, are respected leaders in their fields. Each HHMI senior international research scholar was awarded a grant of $100,000 per year over five years, and will present their research at scientific meetings held at HHMI. The gatherings are intended to facilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaboration with other HHMI scientists. (C) The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) HHMI, in partnership with the University of KwaZulu-Natal (UKZN) in South Africa, has established an international research center focused on making major scientific contributions to the worldwide effort to control the devastating co-epidemic of tuberculosis (TB) and HIV. The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) is an independent non-profit association incorporated under South African law. It is placing a major emphasis on establishing a world-class research program focused on the scientific discoveries about the infecting organisms and helping to train a new generation of scientists in Africa. HHMI has committed over $70 million to K-RITH over 10 years, including support provided during its fiscal year ended August 31, 2013. UKZN is making substantial financial and in-kind commitments to K-RITH as well. The need for more research on TB and HIV is substantial. South Africa has more residents infected with HIV than any other nation in the world. In addition, it has one of the highest per capita rates of TB in the world. K-RITH continues to recruit early career and established research scientists, in addition to awarding grants to support collaborative research and educational activities between South African scientists and their international colleagues. K-RITH formally opened its new research building in October 2012 on the campus of the Nelson R. Mandela School of Medicine in Durban. The new facility includes high-level biosafety (BSL-3) laboratories equipped for HIV and TB research. K-RITH aims to be fully established and integrated into the overall South African and global research enterprise by 2018.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2012

Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" to Form 990, Part IV, line 33, 34, 35, 36, or 37.
MediumBulletAttach to Form 990. MediumBullet See separate instructions.

OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE
 
Employer identification number

59-0735717
Part I
Identification of Disregarded Entities (Complete if the organization answered "Yes" to Form 990, Part IV, line 33.)
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income


 		(e)
End-of-year assets


 		(f)
Direct controlling
entity
(1) HHMI Cayman I Company
Walker Walkers House Mary Street
George Town,Grand Cayman  
CJ
Investment CJ -485,648 40,000 HHMI
 
(2) HHMI II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 38,868,145 400,289,249 HHMI
 
(3) HHMI IV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 6,027 47,730 HHMI
 
(4) HHMI V LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   12,018 HHMI
 
(5) HHMI XII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 26,779 26,811 HHMI
 
(6) HHMI XVI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 8,109,087 543,737,614 HHMI
 
(7) Sprugos Mauritius I Ltd
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment MP -11,402,821 82,046,540 HHMI
 
(8) Sprugos Investments II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 6,363,013 40,263,485 HHMI
 
(9) Sprugos Investments V LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 26,529,033 184,658,554 HHMI
 
(10) Sprugos Investments VII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 49,422,964 211,456,475 HHMI
 
(11) Sprugos Investments VIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 2,977,507 126,167,236 HHMI
 
(12) Sprugos Investments X LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   0 HHMI
 
(13) Sprugos Investments XI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 9,672,846 139,711,606 HHMI
 
(14) Sprugos Investments XII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -328,301 748,029 HHMI
 
(15) Sprugos Investments XIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -204,815 0 HHMI
 
(16) Private Equity Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   0 HHMI
 
(17) Private Equity Holding-Ahead LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 939,796 2,601,434 HHMI
 
(18) Private Equity Holding-Alexa LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -2,366 26,081 HHMI
 
(19) Private Equity Holding-CS Capital LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -1,032,669 14,320,516 HHMI
 
(20) Private Equity Holding-Eurocastle LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 38,521 3,993,818 HHMI
 
(21) Private Equity Holding-Favrille LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   0 HHMI
 
(22) Private Equity Holding-KAP LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -1 0 HHMI
 
(23) Private Equity Holding-Royce LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE   0 HHMI
 
(24) Private Equity Holding-Storeretro LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -1 0 HHMI
 
(25) Private Equity Holding-Xenoport LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(26) HHMI FI I LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(27) Janelia Farm Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment VA     HHMI
 
(28) Selden Island Holding LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment VA     HHMI
 
(29) HHMI I LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(30) HHMI III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(31) HHMI VI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(32) HHMI VII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE 6,860,651 32,967,996 HHMI
 
(33) HHMI VIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(34) HHMI IX LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(35) HHMI X LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(36) HHMI XI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(37) HHMI XIII LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(38) HHMI XIV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(39) HHMI XV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(40) Sprugos Investments LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(41) Sprugos Investments III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(42) Sprugos Investment IV LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(43) Sprugos Investment VI LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(44) Sprugos Investments IX LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(45) Sprugos-French LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(46) Private Equity Holding II LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(47) Private Equity Holding III LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(48) Relative Value Strategies LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE     HHMI
 
(49) PSG LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Investment DE -4,585,917 56,094,466 HHMI
 
(50) HHMI-SA LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Research DE   418,995 HHMI
 
(51) Tangled Bank Studios LLC
4000 Jones Bridge Road
Chevy Chase,MD20815
 Film Prod. DE     HHMI
 
Part II
Identification of Related Tax-Exempt Organizations (Complete if the organization answered "Yes" to Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.)
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section


 		(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled entity?
Yes No












For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2012
Schedule R (Form 990) 2012
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership (Complete if the organization answered "Yes" to Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.)
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V—UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No
(1) Alchemy Plan (Aviator) LP

Trafalgar Court Les Banques
St. Peter Port   GY1 3QL
GK
98-0186264 		Investment GK HHMI
  		excluded -13,188,176 0   No     No 99.000 %
(2) GEM HLT CO-INV Fund LP

900 North Michigan Avenue Suite 14
Chicago,IL60611
26-3195475 		Investment IL HHMI
  		excluded 1,731,679 21,393,476   No     No 62.000 %
(3) HHMI Investment LP

300 Crescent Court Suite 1111
Dallas,TX75201
20-3752378 		Investment DE HHMI
  		excluded -3,651,659 0   No     No 97.000 %
(4) Luminus Credit Opportunities PIE I LP

1700 Broadway 38th Floor
New York,NY10019
26-1963557 		Investment NY HHMI
  		excluded 1,949,524 69,281,134   No     No 99.000 %






Part IV
Identification of Related Organizations Taxable as a Corporation or Trust (Complete if the organization answered "Yes" to Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.)
(a)
Name, address, and EIN of
related organization
 		(b)
Primary activity
 		(c)
Legal
domicile
(state or foreign
country)
 		(d)
Direct controlling
entity
 		(e)
Type of entity
(C corp, S corp,
or trust) 		(f)
Share of total income
 		(g)
Share of end-of-year
assets
 		(h)
Percentage
ownership
 		(i)
Section 512(b)(13) controlled entity?
Yes No
(1) HHMI Real Estate Inc

4000 Jones Bridge Road
Chevy Chase,MD20815
20-3967202 		Investment DE HHMI
  		C Corp 2,944,105 9,024,484 100.000 % Yes  
(2) Pleasant Valley Investments LP

80 Raffles Place 35-41UOB Plaza 1
Singapore   048624
SN
98-0586696 		Investment CJ HHMI
  		For. LP/US Corp 5,885,043 36,558,329 51.000 % Yes  
(3) HH Ellington Fund LTD

Walker House 87 Mary Street
Georgetown,GrKY1-9005
CJ
99-9999999 		Investment CJ HHMI
  		For. LP/US Corp 37,189,179 185,967,772 94.000 % Yes  








Schedule R (Form 990) 2012
Schedule R (Form 990) 2012
Page 3
Part V
Transactions With Related Organizations (Complete if the organization answered "Yes" to Form 990, Part IV, line 34, 35b, or 36.)
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest (ii) annuities (iii) royalties or (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .
1a
 
No
b Gift, grant, or capital contribution to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1b
Yes
 
c Gift, grant, or capital contribution from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1c
 
No
d Loans or loan guarantees to or for related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1d
 
No
e Loans or loan guarantees by related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1e
 
No
f Dividends from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1f
 
No
g Sale of assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1g
 
No
h Purchase of assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1h
 
No
i Exchange of assets with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) . . . . . . . . . . . . . . . . . . . .
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) . . . . . . . . . . . . . . . . . . . .
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) . . . . . . . . . . . . . . . . . . . . .
1n
 
No
o Sharing of paid employees with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1o
 
No
p Reimbursement paid to related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1p
 
No
q Reimbursement paid by related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1q
 
No
r Other transfer of cash or property to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1r
Yes
 
s Other transfer of cash or property from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1s
Yes
 
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of other organization 		(b)
Transaction
type (a-s) 		(c)
Amount involved 		(d)
Method of determining amount involved
(1) Pleasant Valley Investments LP

 r 14,702,039  
(2) HH Ellington Master Fund LTD

 b 110,000,000  
(3) HHMI Investment LP

 b 1,823,747  
(4) Alchemy Plan (Aviator)LP

 s 166,234  
(5) GEM HLT Co-inv Fund LP

 s 1,200,000  
(6) HHMI Investment LP

 s 161,303,238  
(7) Luminus Credit Opportunities PIE I LP

 s 68,326,770  
Schedule R (Form 990) 2012
Schedule R (Form 990) 2012
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership (Complete if the organization answered "Yes" to Form 990, Part IV, line 37.)
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income (related, unrelated, excluded from tax under section 512-514)

(e)
Are all partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V—UBI
amount in box 20
of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2012
Schedule R (Form 990) 2012
Page 5
Part VII
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule R (see instructions).
Identifier Return Reference Explanation

Additional Data


Software ID:  
Software Version: