Form990
Click to see attachment
Department of the Treasury
Internal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except black lung benefit trust or private foundation)

MediumBullet The organization may have to use a copy of this return to satisfy state reporting requirements.
OMB No. 1545-0047
2012
Open to Public Inspection
A For the 2012 calendar year, or tax year beginning 07-01-2012 , 2012, and ending 06-30-2013
BCheck if applicable:
CName of organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Doing Business As
 
 
Number and street (or P.O. box if mail is not delivered to street address)
10901 NORTH TORREY PINES ROAD
Suite
Room/suite
City or town, state or country, and ZIP + 4
LA JOLLA, CA92037
D Employer identification number

51-0197108
E Telephone number

G Gross receipts $ 162,967,633
F Name and address of principal officer:
KRISTIINA VUORI MD PHD
10901 N TORREY PINES ROAD
LA JOLLA,CA92037
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.SANFORDBURNHAM.ORG
H(a)
Is this a group return for
affiliates?
H(b)
Are all affiliates included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:
 
L Year of formation: 1976
M State of legal domicile: CA
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: SEE SCHEDULE O
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 20
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 17
5 Total number of individuals employed in calendar year 2011 (Part V, line 2a) ...... 5 1,130
6 Total number of volunteers (estimate if necessary) ............. 6 22
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 915,264
b Net unrelated business taxable income from Form 990-T, line 34 ......... 7b 144,833
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 156,880,684 146,497,371
9 Program service revenue (Part VIII, line 2g) ......... 774,874 1,077,105
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 1,048,418 1,074,044
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 3,393,059 4,061,676
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)................... 162,097,035 152,710,196
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 0 0
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 82,248,203 79,343,211
16a Professional fundraising fees (Part IX, column (A), line 11e)..... 196,445 33,225
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet2,463,153    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 75,933,118 69,599,654
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 158,377,766 148,976,090
19 Revenue less expenses. Subtract line 18 from line 12....... 3,719,269 3,734,106
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 316,383,458 315,253,706
21 Total liabilities (Part X, line 26)............. 109,159,237 100,215,489
22 Net assets or fund balances. Subtract line 21 from line 20..... 207,224,221 215,038,217
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
 
Preparer's signature
Date
PTIN
Firm's name MediumBullet

Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ............
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y
Form 990 (2012)
Form 990 (2012)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response to any question in this Part III ...............
1
Briefly describe the organization’s mission: SANFORD BURNHAM MEDICAL RESEARCH INSTITUTE CONDUCTS WORLD-CLASS COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ......................
If “Yes,” describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program services? ............................
If “Yes,” describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 129,077,713 including grants of $ 0 ) (Revenue $ 1,502,152 )
SEE SCHEDULE O
4b (Code:   ) (Expenses $   including grants of $   ) (Revenue $   )
4c (Code:   ) (Expenses $   including grants of $   ) (Revenue $   )
4d Other program services (Describe in Schedule O.)
(Expenses $   including grants of $   ) (Revenue $   )
4e Total program service expensesMediumBullet129,077,713
Form 990 (2012)
Form 990 (2012)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If “Yes,” complete Schedule AClick to see attachment........................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? Click to see attachment...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If “Yes,” complete Schedule C, Part IClick to see attachment..........
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If “Yes,” complete Schedule C, Part IIClick to see attachment........
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If “Yes,” complete Schedule C,
Part IIIClick to see attachment............................
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If “Yes,” complete Schedule D, Part IClick to see attachment........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If “Yes,” complete Schedule D, Part IIClick to see attachment...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If “Yes,” complete Schedule D, Part III Click to see attachment....................
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If “Yes,” complete Schedule D, Part IVClick to see attachment..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments? If “Yes,” complete Schedule D, Part VClick to see attachment......
10
Yes
 
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10?
If “Yes,” complete Schedule D, Part VI.Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIIClick to see attachment.......
11b
 
No
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part VIIIClick to see attachment.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If “Yes,” complete Schedule D, Part IXClick to see attachment............
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If “Yes,” complete Schedule D, Part XClick to see attachment
11e
 
No
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If “Yes,” complete Schedule D, Part XClick to see attachment.........................
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year?
If “Yes,” complete Schedule D, Parts XI and XII Click to see attachment.................
12a
Yes
 
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If “Yes,” and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
 
No
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If “Yes,” complete Schedule E....
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States?.....
14a
Yes
 
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If “Yes,” complete Schedule F, Parts I and IV......... Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or assistance to any organization or entity located outside the United States? If “Yes,” complete Schedule F, Parts II and IVClick to see attachment
15
 
No
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or assistance to individuals located outside the United States? If “Yes,” complete Schedule F, Parts III and IV... Click to see attachment
16
 
No
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If “Yes,” complete Schedule G, Part I (see instructions).... Click to see attachment
17
Yes
 
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If “Yes,” complete Schedule G, Part II............ Click to see attachment
18
Yes
 
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If “Yes,” complete Schedule G, Part III................... Click to see attachment
19
 
No
20a
Did the organization operate one or more hospital facilities? If “Yes,” complete Schedule H....
20a
 
No
b
If “Yes” to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
Form 990 (2012)
Form 990 (2012)
Page 4
Part IV
Checklist of Required Schedules (continued)
21
Did the organization report more than $5,000 of grants and other assistance to any government or organization in the United States on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II...
21
 
No
22
Did the organization report more than $5,000 of grants and other assistance to individuals in the United States on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........
22
 
No
23
Did the organization answer “Yes” to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If “Yes,” complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25................ Click to see attachment
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds?......................
24c
 
No
d
Did the organization act as an “on behalf of” issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3) and 501(c)(4) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If “Yes,” complete Schedule L, Part I........ Click to see attachment
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If “Yes,” complete Schedule L, Part I................... Click to see attachment
25b
 
No
26
Was a loan to or by a current or former officer, director, trustee, key employee, highest compensated employee, or disqualified person outstanding as of the end of the organization’s tax year? If “Yes,” complete Schedule L,
Part II.......................... Click to see attachment
26
Yes
 
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or family member of any of these persons? If “Yes,” complete Schedule L, Part III......... Click to see attachment
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If “Yes,” complete Schedule L, Part IV .......................... Click to see attachment
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If “Yes,”
complete Schedule L, Part IV..................... Click to see attachment
28b
Yes
 
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or direct or indirect owner? If “Yes,” complete Schedule L, Part IV... Click to see attachment
28c
Yes
 
29
Did the organization receive more than $25,000 in non-cash contributions? If “Yes,” complete Schedule M..Click to see attachment
29
Yes
 
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If “Yes,” complete Schedule M............. Click to see attachment
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If “Yes,” complete Schedule N,
Part I...........................
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If “Yes,” complete Schedule N, Part II......................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If “Yes,” complete Schedule R, Part I........
33
 
No
34
Was the organization related to any tax-exempt or taxable entity? If “Yes,” complete Schedule R, Part II, III, or IV, and Part V, line 1........................
34
 
No
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
 
No
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If “Yes,” complete Schedule R, Part V, line 2...
35b
 
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If “Yes,” complete Schedule R, Part V, line 2.............
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If “Yes,” complete Schedule R, Part VI
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2012)
Form 990 (2012)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response to any question in this Part V ...............
Yes
No
1a
Enter the number reported in Box 3 of Form 1096 Enter -0- if not applicable ..
1a
222
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
1,130
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
 
No
b
If “Yes,” has it filed a Form 990-T for this year? If “No,” provide an explanation in Schedule O.....
3b
 
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)?..........................
4a
 
No
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for Form TD F 90-22.1, Report of Foreign Bank and Financial Accounts.
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year?..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If “Yes,” to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions?...
6a
 
No
b
If “Yes,” did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible?........................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor?....................
7a
Yes
 
b
If “Yes,” did the organization notify the donor of the value of the goods or services provided?.....
7b
Yes
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282?...........................
7c
 
No
d
If “Yes,” indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?............................
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract?..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?............................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C?..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds and section 509(a)(3) supporting organizations. Did the supporting organization, or a donor advised fund maintained by a sponsoring organization, have excess business holdings at any time during the year?............
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the organization make any taxable distributions under section 4966?..........
9a
 
 
b
Did the organization make a distribution to a donor, donor advisor, or related person?.......
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If “Yes,” enter the amount of tax-exempt interest received or accrued during the year. ....................
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If “No,” provide an explanation in Schedule O..
14b
 
 
Form 990 (2012)
Form 990 (2012)
Page 6
Part VI
Governance, Management, and Disclosure For each “Yes” response to lines 2 through 7b below, and for a “No” response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response to any question in this Part VI ...............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year .....................
1a
20
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent ...................
1b
17
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
 
No
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? ...........................
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
 
No
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .........................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If “Yes,” provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If “Yes,” did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If “No,” go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If “Yes,” describe in Schedule O how this was done.......................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
 
No
b
Other officers or key employees of the organization ................
15b
 
No
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If “Yes,” did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
AR , CA , CT , KS , ME , MD , MA , MI , NH , NJ , NY , NC , OH , OR , PA , RI , UT , VA , WA
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how), the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, physical address, and telephone number of the person who possesses the books and records of the organization:
MediumBulletGARY F RAISL EDD EVP CAO CFO10901 N TORREY PINES ROADLA JOLLACA92037 (858) 646-3100
Form 990 (2012)
Form 990 (2012)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response to any question in this Part VII ...............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(1) LORENZO BERHO........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(2) JAMES BLAIR........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(3) SHEHAN DISSANAYAKE........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(4) DANIEL EPSTEIN........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(5) WAIN FISHBURN........................................................................
TRUSTEE/CHAIRMAN
 1.0
.......................   		X   X       0 0 0
(6) PAULINE FOSTER........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(7) PATRICK GERAGHTY........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(8) ALAN GLEICHER........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(9) JEANNE HERBERGER........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(10) BRENT JACOBS........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(11) JAMES JARDON........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(12) ROBERT LAUER........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(13) BERNARD MACHEN........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(14) NICOLAS NIERENBERG........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(15) HENRY NORDOFF........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(16) DOUGLAS OBENSHAIN........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(17) PETER PREUSS........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
Form 990 (2012)
Form 990 (2012)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; Officer; Key Employee; Highest compensated employee; Former;
(18) DUANE ROTH........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(19) JAN TUTTLEMAN........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(20) ANDREW VITERBI........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(21) ALLEN WEISS........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(22) GAYLE WILSON........................................................................
TRUSTEE
 1.0
.......................   		X           0 0 0
(23) JOHN C REED MD PHD........................................................................
CEO
 50.0
.......................   		X   X       680,710 0 400,613
(24) KRISTIINA VUORI MD PHD........................................................................
PRESIDENT/INTERIM CEO
 50.0
.......................   		X   X       614,402 0 336,101
(25) GARY F RAISL EDD........................................................................
EVP/CAO/CFO/TREASURER
 50.0
.......................   		    X       432,812 0 48,941
(26) MARGARET DUNBAR JD........................................................................
SECRETARY/SR DIRECTOR IP
 50.0
.......................0.0 		    X       165,701 0 15,321
(27) STUART LIPTON MD PHD........................................................................
CENTER DIRECTOR
 50.0
.......................   		        X   448,146 0 52,739
(28) DANIEL KELLY MD........................................................................
CNTR DIR./SCI. DIR. AT LK NONA
 50.0
.......................0.0 		        X   446,021 0 50,001
(29) CARL WARE PHD........................................................................
CENTER DIRECTOR
 50.0
.......................   		        X   347,871 0 34,808
(30) CYRIL DOUCET........................................................................
VP, ADMIN. AT LAKE NONA
 50.0
.......................   		        X   307,670 0 35,312
(31) JORGE MOSCAT PHD........................................................................
PROGRAM DIRECTOR
 50.0
.......................   		        X   279,856 0 45,878
1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)............MediumBullet 3,723,189 0 1,019,714
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organizationMediumBullet128
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If “Yes,” complete Schedule J for such individual ..............
3
 
No
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If “Yes,” complete Schedule J for such individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If “Yes,” complete Schedule J for such person ........
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
Pabst Patent Group, 1545 Peachtree St NE Suite 320ATLANTAGA30309 LEGAL 498,923
DLA Piper US LLP, PO BOX 64029BALTIMOREMD21264 LEGAL 459,291
Deloitte Touche, 200 South Orange Suite 200SAN DIEGOCA92130 AUDIT 297,488
Berman Property Management, 100 W Lucerne Circle Suite 403ORLANDOFL32801 Janitorial 215,592
Jones Day, 12265 El Camino Real Suite 200SAN DIEGOCA92130 Legal 200,927
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet7
Form 990 (2012)
Form 990 (2012)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response to any question in this Part VIII ..............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512, 513, or 514
Contributions, Gifts, Grants and Other Similar Amounts 1a Federated campaigns..1a  
b Membership dues....1b  
c Fundraising events....1c 1,090,045
d Related organizations...1d  
e Government grants (contributions)1e 110,044,226
f All other contributions, gifts, grants, and
similar amounts not included above1f 		35,363,100
g Noncash contributions included in lines
1a-1f:$ 		1,063,332
h Total. Add lines 1a-1f.......MediumBullet 146,497,371
Program Service Revenue Business Code
2a Shared Services revenue 541900 1,077,105 1,077,105    
b
c
d
e
f All other program service revenue .        
g Total. Add lines 2a–2f........MediumBullet 1,077,105
Other Revenue 3 Investment income (including dividends, interest, and other similar amounts).......MediumBullet 919,164     919,164
4 Income from investment of tax-exempt bond proceeds..MediumBullet 44,371     44,371
5 Royalties...........MediumBullet 2,582,193     2,582,193
(i) Real (ii) Personal
6a Gross rents 454,672  
b Less: rental expenses    
c Rental income or (loss) 454,672 0
d Net rental income or (loss).......MediumBullet 454,672     454,672
(i) Securities (ii) Other
7a Gross amount from sales of assets other than inventory 10,003,466  
b Less: cost or other basis and sales expenses 9,892,957  
c Gain or (loss) 110,509  
d Net gain or (loss)..........MediumBullet 110,509     110,509
8a Gross income from fundraising events (not including
$ 1,090,045
of contributions reported on line 1c). See Part IV, line 18 ..
a 49,000
b Less: direct expenses ...b 364,480
c Net income or (loss) from fundraising events..MediumBullet -315,480   -315,480
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities...MediumBullet 0      
10a Gross sales of inventory, less
returns and allowances .
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet 0      
Miscellaneous Revenue Business Code
11a RESEARCH 541900 915,264   915,264  
b REAGENTS -BY PRODUCT OF EXEMPT RESEARCH 541900 168,950 168,950    
c SYMPOSIUM FEES 900099 71,888 71,888    
d All other revenue .... 184,189 184,189    
e Total. Add lines 11a–11d ...... MediumBullet 1,340,291
12 Total revenue. See Instructions......MediumBullet 152,710,196 1,502,132 915,264 3,795,429
Form 990 (2012)
Form 990 (2012)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response to any question in this Part IX ...............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to governments and organizations in the United States. See Part IV, line 21 0  
2 Grants and other assistance to individuals in the United States. See Part IV, line 22 0  
3 Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16 0  
4 Benefits paid to or for members 0  
5 Compensation of current officers, directors, trustees, and key employees .... 1,841,699 2,115,745 -274,046  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .... 191,138 191,138    
7 Other salaries and wages 60,510,538 50,837,956 8,237,101 1,435,481
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 4,167,689 3,388,695 689,405 89,589
9 Other employee benefits ....... 8,906,179 7,220,690 1,521,434 164,055
10 Payroll taxes ........... 3,725,968 3,053,466 583,449 89,053
11 Fees for services (non-employees):        
a Management ...... 1,464,931 1,119,204 345,480 247
b Legal ......... 379,952 44,781 335,171  
c Accounting ........... 305,901   305,901  
d Lobbying ........... 123,133 245 122,888  
e Professional fundraising services. See Part IV, line 17 33,225 33,225
f Investment management fees ...... 12,288   12,288  
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) ........ 756,085 575,134 164,463 16,488
12 Advertising and promotion .... 53,399 220 15,239 37,940
13 Office expenses ....... 9,308,668 8,628,160 589,168 91,340
14 Information technology ...... 1,315,093 1,009,512 281,248 24,333
15 Royalties .. 0      
16 Occupancy ........... 13,284,137 11,802,321 1,364,933 116,883
17 Travel ............ 785,657 678,326 85,927 21,404
18 Payments of travel or entertainment expenses for any federal, state, or local public officials ...... 0      
19 Conferences, conventions, and meetings .... 1,194,284 844,290 319,367 30,627
20 Interest ........... 3,710,284 3,367,833 307,574 34,877
21 Payments to affiliates ....... 0      
22 Depreciation, depletion, and amortization ..... 19,065,947 16,654,008 2,263,256 148,683
23 Insurance .............. 85,144   85,144  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a RESEARCH SUPPLIES & EXPENSES 10,479,721 10,479,721    
b SCIENTIFIC COLLABORATIONS 6,616,691 6,616,691    
c RECRUITMENT 385,513 330,049 30,955 24,509
d MISCELLANEOUS 272,826 119,528 48,879 104,419
e All other expenses        
25 Total functional expenses. Add lines 1 through 24e 148,976,090 129,077,713 17,435,224 2,463,153
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2012)
Form 990 (2012)
Page 11
Part X Balance Sheet Check if Schedule O contains a response to any question in this Part X ...............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash—non-interest-bearing ............. 2,011,199 1 1,669,367
2 Savings and temporary cash investments ......... 7,878,644 2 17,237,397
3 Pledges and grants receivable, net ........... 32,920,556 3 28,941,590
4 Accounts receivable, net ............. 230,956 4 503,732
5 Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
Schedule L ..................
1,142,218 5 1,186,166
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
0 6 0
7 Notes and loans receivable, net ............. 6,173,667 7 6,113,457
8 Inventories for sale or use .............. 629,240 8 448,178
9 Prepaid expenses and deferred charges .......... 8,065,520 9 8,412,047
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 288,293,600
b Less: accumulated depreciation ..... 10b 133,199,334 167,593,019 10c 155,094,266
11 Investments—publicly traded securities .......... 86,413,448 11 92,491,582
12 Investments—other securities. See Part IV, line 11 ..... 0 12 0
13 Investments—program-related. See Part IV, line 11 ..... 0 13 0
14 Intangible assets ............... 0 14 0
15 Other assets. See Part IV, line 11 ........... 3,324,991 15 3,155,924
16 Total assets. Add lines 1 through 15 (must equal line 34)...... 316,383,458 16 315,253,706
Liabilities 17 Accounts payable and accrued expenses ......... 20,849,521 17 17,867,974
18 Grants payable ................. 0 18 0
19 Deferred revenue ................ 11,772,199 19 10,516,399
20 Tax-exempt bond liabilities ............. 76,537,517 20 71,831,116
21 Escrow or custodial account liability. Complete Part IV of Schedule D.. 0 21 0
22 Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L.......... 0 22 0
23 Secured mortgages and notes payable to unrelated third parties .. 0 23 0
24 Unsecured notes and loans payable to unrelated third parties .... 0 24 0
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D.................... 0 25 0
26 Total liabilities. Add lines 17 through 25......... 109,159,237 26 100,215,489
Net Assets or Fund Balance Organizations that follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets .............. 74,517,313 27 77,369,944
28 Temporarily restricted net assets ........... 120,682,803 28 125,635,591
29 Permanently restricted net assets ........... 12,024,105 29 12,032,682
Organizations that do not follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds ........   30  
31 Paid-in or capital surplus, or land, building or equipment fund .....   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ........... 207,224,221 33 215,038,217
34 Total liabilities and net assets/fund balances ........ 316,383,458 34 315,253,706
Form 990 (2012)
Form 990 (2012)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response to any question in this Part XI ...............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
152,710,196
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
148,976,090
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
3,734,106
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) ..
4
207,224,221
5
Net unrealized gains (losses) on investments ...............
5
2,773,536
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
1,306,354
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 33, column (B))
10
215,038,217
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response to any question in this Part XII ..............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If “Yes,” to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
Yes
 
b
If “Yes,” did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits
3b
Yes
 
Form 990 (2012)
Form 990, Special Condition Description:
Special Condition Description
Additional Data


Software ID:  
Software Version:  
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ. right arrow See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
f
g
(i) A person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the supported organization? ................
11g(i)
 
 
(ii) A family member of a person described in (i) above? ......................
11g(ii)
 
 
(iii) A 35% controlled entity of a person described in (i) or (ii) above? ................
11g(iii)
 
 
h
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) (iv) Is the organization in col. (i) listed in your governing document? (v) Did you notify the organization in col. (i) of your support? (vi) Is the organization in col. (i) organized in the U.S.? (vii) Amount of monetary support
Yes No Yes No Yes No
Total                  

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .... 209,859,230 150,769,181 160,093,433 156,880,684 147,266,803 824,869,331
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......           0
3 The value of services or facilities furnished by a governmental unit to the organization without charge..           0
4 Total. Add lines 1 through 3 209,859,230 150,769,181 160,093,433 156,880,684 147,266,803 824,869,331
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..           23,709,484
6 Public support. Subtract line 5 from line 4.           801,159,847
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
7 Amounts from line 4.. 209,859,230 150,769,181 160,093,433 156,880,684 147,266,803 824,869,331
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... 1,995,011 1,354,102 2,037,946 4,402,201 4,133,944 13,923,204
9 Net income from unrelated business activities, whether or not the business is regularly carried on..           0
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.).. 286,205 343,630 907,754 370,643 425,047 2,333,279
11 Total support (Add lines 7 through 10).           841,125,814
12
12
2,283,629
13
First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization, check this box and stop here........................................right arrow
Section C. Computation of Public Support Percentage
14
14
95.249 %
15
15
96.180 %
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513..            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support (Subtract line 7c from line 6.)            
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2008 (b) 2009 (c) 2010 (d) 2011 (e) 2012 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2012
Schedule A (Form 990 or 990-EZ) 2012
Page 4
Part IV
Supplemental Information. Complete this part to provide the explanations required by Part II, line 10; Part II, line 17a or 17b; and Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Explanation
 
 
 
 
Schedule A (Form 990 or 990-EZ) 2012

Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors
Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
OMB No. 1545-0047
2012
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ





Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note. Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......................... Arrow Bullet   $    
Caution. An organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2 of its Form 990; or check the box on line H of its
Form 990-EZ or on Part I, line 2 of its Form 990-PF, to certify that it does not meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2012)

Schedule B (Form 990, 990-EZ, or 990-PF) (2012)
Page 2
Name of organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
  		Employer identification number

51-0197108
Part I
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
     
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
RESTRICTED
 

     
RESTRICTED
RESTRICTED  
RESTRICTED, RESTRICTED   RESTRICTED

$RESTRICTED


(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  


(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  


(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  


(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  


(Complete Part II if there is a noncash contribution.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

     
 
   

$  


(Complete Part II if there is a noncash contribution.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2012)

Schedule B (Form 990, 990-EZ, or 990-PF) (2012)
Page 3
Name of organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
  		Employer identification number

51-0197108
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
     
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2012)

Schedule B (Form 990, 990-EZ, or 990-PF) (2012)
Page 4
Name of organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
  		Employer identification number

51-0197108
Part III
Exclusively religious, charitable, etc., individual contributions to section 501(c)(7), (8), or (10) organizations
that total more than $1,000 for the year. Complete columns (a) through (e) and the following line entry.
For organizations completing Part III, enter the total of exclusively religious, charitable, etc.,
contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
       
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2012)

Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet Complete if the organization is described below.SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd Bullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
If the organization answered “Yes” to Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered “Yes” to Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered “Yes” to Form 990, Part IV, Line 5 (Proxy Tax) or Form 990-EZ, Part V, line 35c (Proxy Tax), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV.
2
Political expenditures ....................................SchCMd Bullet
$  
3
Volunteer hours ........................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 .........SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 ......SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ..............
4a
Was a correction made? .........................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ...................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b..SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ..........................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.










For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2012

Schedule C (Form 990 or 990-EZ) 2012
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
organization's
totals 		(b) Affiliated group
totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......    
b Total lobbying expenditures to influence a legislative body (direct lobbying) .......    
c Total lobbying expenditures (add lines 1a and 1b) ...................    
d Other exempt purpose expenditures ........................    
e Total exempt purpose expenditures (add lines 1c and 1d) ...............    
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		    
  If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:    
  Not over $500,00020% of the amount on line 1e.    
  Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.    
  Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.    
  Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.    
  Over $17,000,000$1,000,000.    
       
g Grassroots nontaxable amount (enter 25% of line 1f) .................    
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................    
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................    
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ......................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the instructions for lines 2a through 2f on page 4.)
Lobbying Expenditures During 4-Year Averaging Period
  Calendar year (or fiscal year
beginning in) 		(a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) Total
             
2a Lobbying nontaxable amount          
             
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		         
             
c Total lobbying expenditures          
             
d Grassroots nontaxable amount          
             
e Grassroots ceiling amount
(150% of line 2d, column (e))		          
             
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2012


Schedule C (Form 990 or 990-EZ) 2012
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each “Yes” response to lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
No
Yes
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? .........................................
 
No
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ....
Yes
 
c
Media advertisements? ....................................
 
No
 
d
Mailings to members, legislators, or the public? .........................
 
No
 
e
Publications, or published or broadcast statements? .......................
 
No
 
f
Grants to other organizations for lobbying purposes? .......................
 
No
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? ........
Yes
 
134,978
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ......
 
No
 
i
Other activities? ..........................
Yes
 
123,133
j
Total. Add lines 1c through 1i ...............................
258,111
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
No
b
If "Yes," enter the amount of any tax incurred under section 4912 .................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 .....
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? .......
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? ..........
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered “No” OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members .....................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).
a
Current year .........................................
2a
 
b
Carryover from last year ....................................
2b
 
c
Total ............................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) ..............
5
 
Part IV
Supplemental Information
Complete this part to provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, line 2; and Part ll-B, line 1. Also, complete this part for any additional information.
Identifier Return Reference Explanation
LOBBYING ACTIVITIES SCHEDULE C, PART II-B LINE 1G - CONTACT AND MEET WITH FEDERAL AND STATE LEGISLATORS AND THEIR STAFF TO SEEK POTENTIAL RESEARCH FUNDING. LINE 1I - DUES TO RESEARCH AND BIOMEDICAL ORGANIZATIONS, A PORTION OF WHICH ARE CONSIDERED LOBBYING. THE INSTITUTE CONTRACTS WITH HURT NORTON AND ASSOCIATES FOR REPRESENTATION IN WASHINGTON, DC, TO INVESTIGATE AND SEEK POTENTIAL FEDERAL RESEARCH FUNDING OPPORTUNITIES OUTSIDE THE TRADITIONAL NIH PROCESS.
Schedule C (Form 990 or 990EZ) 2012

Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b
SchDMd Bullet Attach to Form 990. SchDMd Bullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate contributions to (during year) ...    
3 Aggregate grants from (during year) .....    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ....................... 2a  
b Total acreage restricted by conservation easements .................. 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register .................... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................
6
Staff and volunteer hours devoted to monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .......................................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenues included in Form 990, Part VIII, line 1 ........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ..............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958) relating to these items:
a
Revenues included in Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b
If "Yes," explain the arrangement in Part XIII and complete the following table:
Amount
c Beginning balance ................................. 1c  
d Additions during the year .............................. 1d  
e Distributions during the year ............................. 1e  
f Ending balance ................................... 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21? .....................
b
If “Yes,” explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ........
Part V
Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.
(a)Current year (b)Prior year b (c)Two years back (d)Three years back (e)Four years back
1a Beginning of year balance .... 21,200,471 21,602,848 19,352,544 15,181,323 17,485,831
b Contributions ........ 9,000 29,575 1,050,000 2,983,403 55,002
c Net investment earnings, gains, and losses 2,517,312 961,439 1,656,322 1,912,336 -2,359,510
d Grants or scholarships .....          
e Other expenditures for facilities
and programs ........ 		921,772 1,393,391 456,018 724,518 0
f Administrative expenses ....          
g End of year balance ...... 22,805,011 21,200,471 21,602,848 19,352,544 15,181,323
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet43.580 %
b
Permanent endowment SchDMd Bullet52.760 %
c
Temporarily restricted endowment SchDMd Bullet3.660 %
The percentages in lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations ........................
3a(i)
 
No
(ii) related organizations ........................
3a(ii)
 
No
b
If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis (investment) (b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .................   25,793,087 25,793,087
b Buildings ................   162,682,250 55,177,762 107,504,488
c Leasehold improvements ............        
d Equipment ................   99,269,550 78,021,572 21,247,978
e Other .................   548,713   548,713
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).).......SchDMdBullet 155,094,266
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 3
Part VII
Investments—Other Securities. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c) Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
Other








Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet  
Part VIII
Investments—Program Related. See Form 990, Part X, line 13.
(a) Description of investment type (b) Book value (c) Method of valuation:
Cost or end-of-year market value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. See Form 990, Part X, line 15.
(a) Description (b) Book value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
Federal income taxes 0








Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 0
2. Fin 48 (ASC 740) Footnote. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII .....................................................
Schedule D (Form 990) 2012

Schedule D (Form 990) 2012
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return
1 Total revenue, gains, and other support per audited financial statements ....... 1 155,472,000
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains on investments .......... 2a 2,773,536
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d 556
e Add lines 2a through 2d ..................... 2e 2,774,092
3 Subtract line 2e from line 1..................... 3 152,697,908
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a 12,288
b Other (Describe in Part XIII.) ........... 4b  
c Add lines 4a and 4b....................... 4c 12,288
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 152,710,196
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return
1 Total expenses and losses per audited financial statements ........... 1 147,658,000
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities .......... 2a  
b Prior year adjustments .............. 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d -1,305,802
e Add lines 2a through 2d...................... 2e -1,305,802
3 Subtract line 2e from line 1..................... 3 148,963,802
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a 12,288
b Other (Describe in Part XIII.) ............ 4b  
c Add lines 4a and 4b....................... 4c 12,288
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 148,976,090
Part XIII
Supplemental Information
Complete this part to provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Identifier Return Reference Explanation
INTENDED USES OF THE ORGANIZATION'S ENDOWMENT FUNDS SCHEDULE D, PART V, LINE 4 THE INSTITUTE'S ENDOWMENT FUNDS ARE ESTABLISHED FOR VARIOUS PURPOSES: SCIENTIFIC RESEARCH, ALS RESEARCH, CEO CHAIR, PRESIDENTIAL CHAIR, CANCER RESEARCH CHAIR, AND UNRESTRICTED AS TO INCOME.
FIN 48 FOOTNOTE SCHEDULE D, PART X, LINE 2 THE INSTITUTE HAS NO MATERIAL DEFERRED TAX ASSETS OR DEFERRED TAX LIABILITIES RECORDED AS OF JUNE 30, 2013 AND 2012. THE INSTITUTE DID NOT RECOGNIZE A CHANGE IN LIABILITY FOR UNRECOGNIZED TAX BENEFITS (THE DIFFERENCE BETWEEN A TAX POSITION TAKEN, OR EXPECTED TO BE TAKEN, IN A TAX RETURN AND THE BENEFIT RECOGNIZED AND MEASURED IN THE FINANCIAL STATEMENTS). THE INSTITUTE'S LIABILITY FOR UNRECOGNIZED TAX BENEFITS WAS $0 AT JUNE 30, 2012 AND 2013.
DETAIL OF AMOUNT SCHEDULE D, PART XI, LINE 2D ROUNDING - 556
DETAIL OF AMOUNT SCEDULE D, PART XII, LINE 2D UNREALIZED GAIN ON INTEREST RATE SWAP $1,306,042 ROUNDING (240) ----------- TOTAL $1,305,802
Schedule D (Form 990) 2012

Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
General Information on Activities Outside the United States. Complete if the organization answered “Yes” to Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of the grants or
assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used to award
the grants or assistance? ...................................
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of grant funds outside
the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in region (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total expenditures
for and investments
in region
Europe (Including Iceland and Greenland)   54 Program Services SEE PART V 108,839
East Asia and the Pacific   28 Program Services SEE PART V 59,718
North America   2 Program Services SEE PART V 1,082
South Asia   3 Program Services SEE PART V 2,503
Middle East and North Africa   4 Program Services SEE PART V 618
South America   5 Program Services SEE PART V 9,960
Central America and the Caribbean   4 Program Services SEE PART V 10,370
Sub-Saharan Africa   5 Program Services SEE PART V 14,880
           
           
           
           
           
           
           
           
           
3a Sub-total .....   76 207,970
b Total from continuation sheets to Part I ...      
c Totals (add lines 3a and 3b)   105 207,970
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered “Yes” to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount of
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter ....MediumBullet
 
3
Enter total number of other organizations or entities .......................MediumBullet
 
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If “Yes,”the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926)......................................
2 Did the organization have an interest in a foreign trust during the tax year? If “Yes,” the organizationmay be required to file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A).......................................
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471)..............................
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If "Yes," the organization may be required to file Form 8621, Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621)
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships. (see Instructions for Form 8865)....................................
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see Instructions for Form 5713)................................................
Schedule F (Form 990) 2012
Schedule F (Form 990) 2012
Page 5
Part V
Supplemental Information
Complete this part to provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).
Identifier ReturnReference Explanation
SUPPLEMENTAL INFORMATION SCHEDULE F, PART I, LINE 3 SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE DOES NOT MAINTAIN ONGOING OPERATIONS IN FOREIGN JURISDICTIONS. HOWEVER, THE INSTITUTE'S SCIENTISTS DO TRAVEL TO VARIOUS SCIENTIFIC CONFERENCES IN OTHER COUNTRIES TO SHARE THE INSTITUTE'S SCIENTIFIC DISCOVERIES, AS WELL AS TO LEARN FROM OTHER SCIENTISTS ACROSS THE WORLD.
SCHEDULE F, PART I, LINE 3, COLUMN E   SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.
ACCOUNTING METHOD SCHEDULE F, PART I, LINE 3, COLUMN F THE ACCRUAL METHOD OF ACCOUNTING WAS USED TO DETERMINE THE AMOUNTS IN PART I, LINE 3, COLUMN (F).
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
Schedule F (Form 990) 2012
Additional Data


Software ID:  
Software Version:  



SCHEDULE G (Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Supplemental Information Regarding
Fundraising or Gaming Activities
Complete if the organization answered "Yes" to Form 990, Part IV, lines 17, 18, or 19, or if the organization entered more than $15,000 on Form 990-EZ, line 6a. Form 990-EZ filers are not required to complete this part. right arrowAttach to Form 990 or Form 990-EZ. right arrowSee separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Fundraising Activities. Complete if the organization answered "Yes" to Form 990, Part IV, line 17.
1
Indicate whether the organization raised funds through any of the following activities. Check all that apply.
a e
b f
c g
d
2a
Did the organization have a written or oral agreement with any individual (including officers, directors, trustees
or key employees listed in Form 990, Part VII) or entity in connection with professional fundraising services?
b
If “Yes,” list the ten highest paid individuals or entities (fundraisers) pursuant to agreements under which the fundraiser is
to be compensated at least $5,000 by the organization.
(i) Name and address of individual
or entity (fundraiser) 		(ii) Activity (iii) Did fundraiser have custody or control of contributions? (iv) Gross receipts
from activity 		(v) Amount paid to
(or retained by)
fundraiser listed in
col. (i) 		(vi) Amount paid to
(or retained by)
organization
Yes No
SEXTON BLUM AND ASSOCIATES CONSULTING   No   22,000 22,000
JEROLD PANAS LINZY PARTNERS CONSULTING   No   11,225 11,225
             
             
             
             
             
             
             
             
Total .................right arrow   33,225 33,225
3
List all states in which the organization is registered or licensed to solicit funds or has been notified it is exempt from registration or licensing.
AL, AK, AR, CA, CT, DE, FL, ID, IN, IA, KS, ME, MD, MA, MI, MO, MT, NE, NV, NH, NJ, NY, NC, OH, OR, PA, RI, SD, TX, UT, VT, VA, WA, WY
For Paperwork Reduction Act Notice, see the Instructions for Form 990or 990-EZ.
Cat. No. 50083H
Schedule G (Form 990 or 990-EZ) 2012
Schedule G (Form 990 or 990-EZ) 2012
Page 2
Part II
Fundraising Events. Complete if the organization answered "Yes" to Form 990, Part IV, line 18, or reported more than $15,000 of fundraising event contributions and gross income on Form 990-EZ, lines 1 and 6b. List events with gross receipts greater than $5,000.
(a) Event #1

GALA
(event type) 		(b) Event #2

BRING IT
(event type) 		(c) Other events

0
(total number) 		(d) Total events
(add col. (a) through col. (c))
VerticalRevenue 1 Gross receipts . . . 1,007,243 114,700   1,121,943
2 Less: Contributions . . 980,243 92,700   1,072,943
3 Gross income (line 1
minus line 2) . . . 		27,000 22,000   49,000
VerticalDirectExpenses 4 Cash prizes . . .        
5 Noncash prizes . .        
6 Rent/facility costs . .   4,000   4,000
7 Food and beverages . 57,830 33,821   91,651
8 Entertainment . . . 96,025 67,190   163,215
9 Other direct expenses . 78,823 26,791   105,614
10 Direct expense summary. Add lines 4 through 9 in column (d) ........... right arrow 364,480
11 Net income summary. Combine line 3, column (d), and line 10. .......... right arrow -315,480
Part III
Gaming. Complete if the organization answered "Yes" to Form 990, Part IV, line 19, or reported more than $15,000 on Form 990-EZ, line 6a.
VerticalRevenue (a) Bingo (b) Pull tabs/Instant
bingo/progressive bingo 		(c) Other gaming (d) Total gaming (add col.(a) through col.(c))
1 Gross revenue . . . .        
VerticalDirectExpenses 2 Cash prizes . . . .        
3 Non-cash prizes . . .        
4 Rent/facility costs . . .        
5 Other direct expenses . .        
6 Volunteer labor . . .
 
 
 
7 Direct expense summary. Add lines 2 through 5 in column (d) ........... right arrow  
8 Net gaming income summary. Combine lines 1 and 7 in column (d) .......... right arrow  
9
Enter the state(s) in which the organization operates gaming activities:
a
Is the organization licensed to operate gaming activities in each of these states? ............
b
If "No," explain:
 
10a
Were any of the organization's gaming licenses revoked, suspended or terminated during the tax year? .....
b
If "Yes," explain:
 
Schedule G (Form 990 or 990-EZ) 2012
Schedule G (Form 990 or 990-EZ) 2012
Page 3
11
Does the organization operate gaming activities with nonmembers? .................
12
Is the organization a grantor, beneficiary or trustee of a trust or a member of a partnership or other entity
formed to administer charitable gaming? ..........................
13
Indicate the percentage of gaming activity operated in:
a
The organization's facility ......................
13a
 
b
An outside facility ........................
13b
 
14
Enter the name and address of the person who prepares the organization's gaming/special events books and records:
Name right arrow
Address right arrow
15a
Does the organization have a contract with a third party from whom the organization receives gaming
revenue? ......................................
b
If "Yes," enter the amount of gaming revenue received by the organization right arrow $   and the
amount of gaming revenue retained by the third party right arrow $   .
c
If "Yes," enter name and address of the third party:
Name right arrow
Address right arrow
 
 
16
Gaming manager information:
Name right arrow
Gaming manager compensation right arrow $  
Description of services provided right arrow
 
17
Mandatory distributions:
a
Is the organization required under state law to make charitable distributions from the gaming proceeds to
retain the state gaming license? ............................
b
Enter the amount of distributions required under state law distributed to other exempt organizations or spent
in the organization's own exempt activities during the tax year right arrow$  
Part IV
Supplemental Information. Complete this part to provide the explanations required by Part I, line 2b, columns (iii) and (v), and Part III, lines 9, 9b, 10b, 15b, 15c, 16, and 17b, as applicable. Also complete this part to provide any additional information (see instructions).
Identifier Return Reference Explanation
Schedule G (Form 990 or 990-EZ) 2012
Additional Data


Software ID:  
Software Version:  
Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" to Form 990,
Part IV, question 23.
SchJMediumBullet Attach to Form 990. SchJMediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all officers,
directors, trustees, and the CEO/Executive Director, regarding the items checked in line 1a? .......
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ................
4a
Yes
 
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
Yes
 
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.
5
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization? .........................
5b
 
No
If "Yes," to line 5a or 5b, describe in Part III.
6
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ...........................
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," to line 6a or 6b, describe in Part III.
7
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
 
No
9
If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2012

Schedule J (Form 990) 2012
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation
reported as deferred
in prior Form 990
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
(1)JOHN C REED MD PHDCEO (i)
(ii)		 658,712
0 		0
0 		21,998
0 		375,000
0 		25,613
0 		1,081,323
0 		0
0
(2)KRISTIINA VUORI MD PHDPRESIDENT/INTERIM CEO (i)
(ii)		 613,442
0 		0
0 		960
0 		325,000
0 		11,101
0 		950,503
0 		0
0
(3)GARY F RAISL EDDEVP/CAO/CFO/TREASURER (i)
(ii)		 429,072
0 		0
0 		3,740
0 		23,319
0 		25,622
0 		481,753
0 		0
0
(4)STUART LIPTON MD PHDCENTER DIRECTOR (i)
(ii)		 444,521
0 		0
0 		3,625
0 		25,000
0 		27,739
0 		500,885
0 		0
0
(5)DANIEL KELLY MDCNTR DIR./SCI. DIR. AT LK NONA (i)
(ii)		 435,055
0 		0
0 		10,966
0 		25,000
0 		25,001
0 		496,022
0 		0
0
(6)CARL WARE PHDCENTER DIRECTOR (i)
(ii)		 344,246
0 		0
0 		3,625
0 		18,738
0 		16,070
0 		382,679
0 		0
0
(7)CYRIL DOUCETVP, ADMIN. AT LAKE NONA (i)
(ii)		 214,715
0 		0
0 		92,955
0 		19,810
0 		15,502
0 		342,982
0 		0
0
(8)JORGE MOSCAT PHDPROGRAM DIRECTOR (i)
(ii)		 277,405
0 		0
0 		2,451
0 		25,000
0 		20,878
0 		325,734
0 		0
0
(9)MARGARET DUNBAR JDSECRETARY/SR DIRECTOR IP (i)
(ii)		 163,906
0 		0
0 		1,795
0 		14,434
0 		887
0 		181,022
0 		0
0
Schedule J (Form 990) 2012

Schedule J (Form 990) 2012
Page 3
Part III
Supplemental Information
Complete this part to provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II.
Also complete this part for any additional information.
Identifier Return Reference Explanation
SUPPLEMENTAL COMPENSATION INFORMATION   FIRST CLASS TRAVEL FIRST CLASS TRAVEL IS GENERALLY NOT PERMITTED, EXCEPT UNDER VERY LIMITED AND RARE CIRCUMSTANCES AND CONDITIONS, SUCH AS A MEDICAL CONDITION REQUIREMENT AND URGENT CIRCUMSTANCES. THIS WAS NOT TREATED AS TAXABLE COMPENSATION. HEALTH OR SOCIAL CLUB DUES HEALTH OR SOCIAL CLUB DUES ARE NEGOTIATED IN THE HIRING PROCESS FOR CERTAIN EMPLOYEES. THE AMOUNTS WERE TREATED AS TAXABLE COMPENSATION.
SEVERENCE PAYMENT OR CHANGE OF CONTROL PAYMENT SCHEDULE J, PART I, QUESTION 4A CYRIL DOUCET WAS PAID $83,261 FOR SEVERANCE DURING THE YEAR.
SUPPLEMENTAL NONQUALIFIED RETIREMENT PLAN SCHEDULE J, PART I, QUESTION 4B THE PARTICIPANTS OF THE 457(F) DEFERRED COMPENSATION PLAN ARE JOHN REED AND KRISTIINA VUORI. VESTING FOR JOHN REED OCCURS THE EARLIEST OF 1/1/2019, OR DISABILITY, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR THE PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. VESTING FOR KRISTIINA VUORI OCCURS THE EARLIEST OF 4/1/2015, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. DISTRIBUTIONS FOR BOTH PARTICIPANTS IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING OF 100% OF THE VALUE OF THE PARTICIPANT'S INVESTMENT (COMPRISED OF INSTITUTE CONTRIBUTIONS TO THE CORPUS PLUS ANY INVESTMENT GAINS OR LOSSES THEREON).
NON-FIXED PAYMENTS SCHEDULE J, PART I, QUESTION 7 SOME SENIOR EXECUTIVES HAVE EMPLOYMENT AGREEMENTS STIPULATING A BONUS WILL BE PAID TO THEM PROVIDED CERTAIN GOALS OR ACCOMPLISHMENTS ARE ACHIEVED.
RETIREMENT AND OTHER DEFERRED COMPENSATION SCHEDULE J, PART II, COLUMN (C) THE AMOUNT REPORTED IN SCHEDULE J, PART II, COLUMN (C) FOR JOHN REED INCLUDES AN ACCRUAL OF $350,000 RELATED TO THE 457(F) PLAN DESCRIBED ABOVE AND FOR KRISTIINA VUORI AN ACCRUAL OF $300,000 RELATED TO THE 457(F) PLAN DESCRIBED ABOVE. THESE AMOUNTS ARE NOT VESTED AND ARE SUBJECT TO A SUBSTANTIAL RISK OF FORFEITURE.
Schedule J (Form 990) 2012

Additional Data


Software ID:  
Software Version:  
Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990. SchKMediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number
51-0197108
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer 		(i) Pool
financing
Yes No Yes No Yes No
A COUNTY OF SAN DIEGO
  		95-6000934 797391G60 02-01-2006 60,572,867 SEE PART VI   X   X   X
B COUNTY OF SAN DIEGO
  		95-6000934 797391K99 11-15-2012 18,885,000 FINANCE PROPERTY AND CAPITAL EQUIP   X   X   X
C CALIFORNIA STATEWIDE COMMUNITIES DEVELOPMENT AUTH
  		95-6000934   08-01-2008 15,300,000 PURCHASE EQUIPMENT   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired . . . . . . . . . . . . . . 0 0 0  
2 Amount of bonds legally defeased . . . . . . . . . . . 0 0 0  
3 Total proceeds of issue . . . . . . . . . . . . . . 60,572,867 18,885,000 15,300,000  
4 Gross proceeds in reserve funds . . . . . . . . . . . . 3,958,500 0 0  
5 Capitalized interest from proceeds . . . . . . . . . . . 0 0 0  
6 Proceeds in refunding escrows . . . . . . . . . . . . 46,326,377 0 0  
7 Issuance costs from proceeds . . . . . . . . . . . . 745,537 0 300,000  
8 Credit enhancement from proceeds . . . . . . . . . . . 0 0 0  
9 Working capital expenditures from proceeds . . . . . . . . . 0 0 0  
10 Capital expenditures from proceeds . . . . . . . . . . . 9,542,453 18,885,000 13,869,914  
11 Other spent proceeds . . . . . . . . . . . . . . 0 0 1,130,086  
12 Other unspent proceeds . . . . . . . . . . . . . . 0 0 0  
13 Year of substantial completion . . . . . . . . . . . . 2000 2012 2012
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? . . . . .   X   X   X    
15 Were the bonds issued as part of an advance refunding issue? . . . . . X     X   X    
16 Has the final allocation of proceeds been made? . . . . . . . . X   X   X      
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . . X   X   X      
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .   X   X   X    
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . . X     X X      
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . . X     X X      
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? . . . . . . . . . . . . . . . . X       X      
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . . X     X X      
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? . X   X   X      
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . . SchKMediumBullet 0% 0% 0%   %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . . SchKMediumBullet   %   %   %   %
6 Total of lines 4 and 5 . . . . . . . . . . . . . . . 0% 0% 0%   %
7 Does the bond issue meet the private security or payment test? . . . . .   X   X   X    
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .   X   X   X    
b If “Yes” to line 8a, enter the percentage of bond-financed property sold or disposed of.   %   %   %   %
c If “Yes” to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .   X   X   X    
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2?
  X   X   X    
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T? . . . . . X     X   X    
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . . X   X   X      
b Exception to rebate? . . . . . . . .   X   X   X    
c No rebate due? . . . . . . . . . .
               
If you checked "No rebate due" in line 2c, provide in Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . .   X X     X    
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?   X X     X    
b Name of provider . . . . . . . . . 0
  		BANK OF AMERICA
  		0
  		 
 
c Term of hedge . . . . . . . . . . 25. 25.    
d Was the hedge superintegrated? . . . . . . X   X          
e Was a hedge terminated? . . . . . . .   X   X        
Schedule K (Form 990) 2012
Schedule K (Form 990) 2012
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .   X   X   X    
b Name of provider . . . . . . . . . 0
  		0
  		0
  		 
 
c Term of GIC . . . . . . . . . .        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .                
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .   X   X   X    
7 Has the organization established written procedures to monitor the requirements of section 148? . . .   X   X   X    
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
1 Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?   X X     X    
Part VI
Supplemental Information. Complete this part to provide additional information for responses to questions on Schedule K (see instructions).
Identifier Return Reference Explanation
SCHEDULE K, PART I, ROW A, COLUMN (F) 0 REFINANCE 1999 BONDS AND FINANCE CAPITAL IMPROVEMENTS & EQUIPMENT.
SCHEDULE K, PART I, ROWS A-C 0 FOR THE BOND ISSUES LISTED IN PART I, THE ALTERNATIVE PERIOD USED FOR THE REPORTING REQUIREMENTS IN THIS SECTION IS THE TWELVE MONTHS ENDED DECEMBER 31, 2012.
SCHEDULE K, PART III, LINE 4, COLUMN (C) 0 THE PERCENTAGE OF FINANCED PROPERTY USED IN A PRIVATE BUSINESS FOR THE ANNUAL MEASUREMENT PERIOD ENDING 12/31/2012 IS 5.61%. THE PRIVATE BUSINESS USE PERCENTAGE OVER THE LIFE OF THE BONDS THROUGH 12/31/2012 IS 3.81%. THE PROJECTED PRIVATE BUSINESS USE PERCENTAGE OVER THE LIFE OF THE BONDS IS 4.19%.
Schedule K (Form 990) 2012

Additional Data


Software ID:  
Software Version:  

Schedule L
(Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Transactions with Interested Persons
MediumBullet Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet Attach to Form 990 or Form 990-EZ. MediumBullet See separate instructions.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Excess Benefit Transactions (section 501(c)(3) and section 501(c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1(a) Name of disqualified person (b) Relationship between disqualified person and organization (c) Description of transaction (d) Corrected?
Yes No





2
Enter the amount of tax incurred by organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image$
 
3
Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image$
 

Part II
Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22
(a) Name of interested person (b) Relationship with organization (c) Purpose of loan (d) Loan to or from the organization? (e)Original principal amount (f)Balance due (g) In default? (h) Approved by board or committee? (i)Written agreement?
To From Yes No Yes No Yes No
(1) DANIEL KELLY EMPLOYEE QUAL. EMPLOYEE RELOC   X 500,000 454,167   No Yes   Yes  
(2) STUART LIPTON EMPLOYEE QUAL. EMPLOYEE RELOC   X 400,000 171,915   No Yes   Yes  
(3) GARY RAISL OFFICER QUAL. EMPLOYEE RELOC   X 225,000 225,000   No Yes   Yes  
(4) JORGE MOSCAT EMPLOYEE QUAL. EMPLOYEE RELOC   X 200,000 86,863   No Yes   Yes  
Total ......Small Bullet $ 937,945
Part III
Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of assistance (d) Type of assistance (e) Purpose of assistance
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 50056A
Schedule L (Form 990 or 990-EZ) 2012
Schedule L (Form 990 or 990-EZ) 2012
Page 2
Part IV
Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of transaction (d) Description of transaction (e) Sharing of organization's revenues?
Yes No
(1) LOCKTON TRUSTEE - DOUG OBENSHAIN 202,078 INSURANCE SERVICES   No
(2) PHILIP GRAHAM - SON OF TRUSTEE TRUSTEE - GAYLE WILSON 191,138 COMPENSATION   No
Part V
Supplemental Information
Complete this part to provide additional information for responses to questions on Schedule L (see instructions).
Identifier Return Reference Explanation
Schedule L (Form 990 or 990-EZ) 2012

Additional Data


Software ID:  
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SCHEDULE M
(Form 990)

Department of the Treasury
Internal Revenue Service
Noncash Contributions
Right pointing arrow large imageComplete if the organizations answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image Attach to Form 990.
OMB No. 1545-0047
2012
Open to Public Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Part I
Types of Property
(a)
Check if applicable 		(b)
Number of contributions or items contributed 		(c)
Noncash contribution amounts reported on
Form 990, Part VIII, line 1g 		(d)
Method of determining
noncash contribution amounts
1 Art—Works of art ....        
2 Art—Historical treasures .        
3 Art—Fractional interests ..        
4 Books and publications ..      
5 Clothing and household
goods ....... 		     
6 Cars and other vehicles ..        
7 Boats and planes ....        
8 Intellectual property ...        
9 Securities—Publicly traded . X 10 1,059,634 FMV
10 Securities—Closely held stock .        
11 Securities—Partnership, LLC,
or trust interests .... 		       
12 Securities—Miscellaneous ..        
13 Qualified conservation
contribution—Historic
structures ..... 		       
14 Qualified conservation
contribution—Other ... 		       
15 Real estate—Residential .        
16 Real estate—Commercial ..        
17 Real estate—Other ...        
18 Collectibles .....        
19 Food inventory ... X 1 1,198 COST/SELLING PRICE
20 Drugs and medical supplies .        
21 Taxidermy ......        
22 Historical artifacts ....        
23 Scientific specimens ..        
24 Archeological artifacts ...        
25 Other Right pointing arrow large image ( MINOR EQUIPMENT ) X 1 2,500 COST/SELLING PRICE
26 Other Right pointing arrow large image( )
27 Other Right pointing arrow large image( )
28 Other Right pointing arrow large image ( )
29
Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement ...
29
 
Yes
No
30a
During the year, did the organization receive by contribution any property reported in Part I, lines 1-28 that it
must hold for at least three years from the date of the initial contribution, and which is not required to be used
for exempt purposes for the entire holding period? ..................
30a
 
No
b
If "Yes," describe the arrangement in Part II.
31
Does the organization have a gift acceptance policy that requires the review of any non-standard contributions?
31
 
No
32a
Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash
contributions? ..........................
32a
 
No
b
If "Yes," describe in Part II.
33
If the organization did not report an amount in column (c) for a type of property for which column (a) is checked,
describe in Part II.
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 51227J
Schedule M (Form 990) (2012)
Schedule M (Form 990) (2012)
Page 2
Part II
Supplemental Information. Complete this part to provide the information required by Part I, lines 30b,
32b, and 33, and whether the organization is reporting in Part I, column (b), the number of contributions, the number of items received, or a combination of both. Also complete this part for any additional information.
Identifier Return Reference Explanation
CONTRIBUTIONS RECEIVED SCHEDULE M, PART I, COLUMN(B) COLUMN B IS REPORTING A COMBINATION OF THE NUMBER OF CONTRIBUTIONS RECEIVED AND THE NUMBER OF ITEMS RECEIVED.
Schedule M (Form 990) (2012)
Additional Data


Software ID:  
Software Version:  
SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
OMB No. 1545-0047
2012
Open to Public
Inspection
Name of the organization
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
 
Employer identification number

51-0197108
Identifier Return Reference Explanation
ORGANIZATION'S MISSION FORM 990 - PART I, LINE 1 & PART III, LINE 1 SANFORD BURNHAM MEDICAL RESEARCH INSTITUTE CONDUCTS WORLD-CLASS COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.
PROGRAM SERVICE ACCOMPLISHMENTS FORM 990, PART III, LINE 4A SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE IS DEDICATED TO DISCOVERING THE FUNDAMENTAL MOLECULAR CAUSES OF DISEASE AND DEVISING THE INNOVATIVE THERAPIES OF TOMORROW. SANFORD-BURNHAM TAKES A UNIQUE, COLLABORATIVE APPROACH TO MEDICAL RESEARCH AND HAS ESTABLISHED MAJOR RESEARCH PROGRAMS IN CANCER, NEURODEGENERATION, DIABETES, AND INFECTIOUS, INFLAMMATORY, AND CHILDHOOD DISEASES. CANCER RESEARCH BREAKING A VICIOUS CYCLE IN PANCREATIC CANCER. PANCREATIC CANCER, WHICH TYPICALLY KILLS PATIENTS A YEAR AFTER DIAGNOSIS, GENERATES TUMORS COMPRISED MOSTLY OF FIBROUS TISSUE. THIS TISSUE OBSTRUCTS BLOOD FLOW, WHICH MAKES IT DIFFICULT FOR DRUGS TO REACH INSIDE TUMORS. WORK PUBLISHED BY DR. GARTH POWIS IN "CANCER RESEARCH" REPORTS THAT HYPOXIA MAY CAUSE SIGNALING THAT LEADS PANCREATIC CANCER CELLS TO RELEASE A PROTEIN THAT IN TURN CAUSES SURROUNDING NORMAL PANCREATIC TISSUE TO PRODUCE LARGE AMOUNTS OF FIBROUS TISSUE. POWIS IDENTIFIED A MOLECULE INCREASED DURING HYPOXIA CALLED HYPOXIA INDUCIBLE FACTOR (HIF) THAT TRIGGERS THE PROTEIN THAT DRIVES FIBROSIS. BY DEVELOPING A DRUG THAT INHIBITS HIF, HE BROKE THE CYCLE OF HYPOXIA AND FIBROSIS-OFFERING A POTENTIAL NEW TREATMENT. NEWLY IDENTIFIED THERAPEUTIC TARGET FOR PROSTATE CANCER. THE LABS OF DRS. MARIA T. DIAZ-MECO AND JORGE MOSCAT HAVE IDENTIFIED HOW AN ENZYME CALLED PKCZ SUPPRESSES PROSTATE TUMOR FORMATION. THE FINDING, WHICH ALSO DESCRIBES A MOLECULAR CHAIN OF EVENTS THAT CONTROLS CELL GROWTH AND METASTASIS, COULD LEAD TO NOVEL WAYS TO CONTROL DISEASE PROGRESSION. THIS STUDY, PUBLISHED IN "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES," SUGGESTS THAT RESTORING PKCZ COULD PROVIDE A NEW APPROACH TO TREATING PROSTATE CANCER. STOPPING MELANOMA BY CHANGING A PROTEIN'S LOCATION. IN A STUDY WITH THE CHEMICAL GENOMICS GROUP, DR. ZE'EV RONAI COMPLETED A PROOF-OF-CONCEPT STUDY THAT IDENTIFIED SMALL MOLECULES THAT PROMOTE THE EXPORT OF A PROTEIN CALLED ATF2 FROM A CELL'S NUCLEUS. EARLIER WORK FROM DR. RONAI'S GROUP SHOWED THAT THE PROTEIN, WHILE INSIDE THE NUCLEUS, PROMOTES CANCER. THE PRESENCE OF ATF2 OUTSIDE THE NUCLEUS IN MITOCHONDRIA, HOWEVER, PROMPTS MELANOMA CANCER CELLS TO SELF-DESTRUCT. IN THEIR NEW STUDY, DR. RONAI'S TEAM SCREENED 3,800 COMPOUNDS TO IDENTIFY SMALL MOLECULES THAT PROMOTE THE MOVEMENT OF ATF2 TO THE CELL'S CYTOPLASM OUTSIDE THE NUCLEUS. TWO COMPOUNDS WERE FOUND TO REDUCE CELL VIABILITY, INHIBIT THE FORMATION OF CELL COLONIES, INHIBIT CELL MOTILITY, AND LEAD TO OTHER DAMAGING EFFECTS. THE STUDY, PUBLISHED IN "CLINICAL CANCER RESEARCH," POINTS THE WAY TOWARD IDENTIFYING SMALL MOLECULES THAT BLOCK THE CANCER-CAUSING FUNCTION OF ATF2. SMIP004 AS A NOVEL TREATMENT FOR ADVANCED PROSTATE CANCER. A MAJOR HALLMARK OF CANCER CELLS IS THEIR ABILITY TO SURVIVE UNDER STRESSFUL CONDITIONS. A NEW STUDY SPEARHEADED BY DR. DIETER WOLF AND HIS TEAM REVEALS HOW A PROMISING ANTICANCER COMPOUND CALLED SMIP004 SPECIFICALLY KILLS PROSTATE CANCER CELLS BY COMPROMISING THEIR ABILITY TO WITHSTAND ENVIRONMENTAL STRESS. THE STUDY, RECENTLY PUBLISHED IN "ONCOTARGET," UNCOVERS NOVEL MECHANISMS OF ANTICANCER ACTIVITY AND COULD LEAD TO THE DEVELOPMENT OF MORE EFFECTIVE THERAPIES FOR ADVANCED AND HARD-TO-TREAT FORMS OF PROSTATE CANCER, AS WELL AS OTHER TYPES OF CANCER. WHY THE SHAPE OF NANOPARTICLES MATTERS. CONVENTIONAL TREATMENTS FOR DISEASES SUCH AS CANCER CAN CARRY HARMFUL SIDE EFFECTS-AND THE PRIMARY REASON IS THAT SUCH TREATMENTS ARE NOT TARGETED SPECIFICALLY TO THE CELLS OF THE BODY WHERE THEY'RE NEEDED. DR. ERKKI RUOSLAHTI AND COLLABORATORS AT UC SANTA BARBARA FOUND THAT THE SHAPE OF NANOPARTICLES CAN ENHANCE DRUG TARGETING. THE STUDY, PUBLISHED IN "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES," FOUND THAT ROD-SHAPED NANOPARTICLES APPEAR TO ADHERE MORE EFFECTIVELY TO THE SURFACE OF ENDOTHELIAL CELLS THAT LINE THE INSIDE OF BLOOD VESSELS. THE FINDINGS HOLD PROMISE IN THE DELIVERY OF DRUGS SUCH AS CHEMOTHERAPEUTICS, WHICH ARE HIGHLY TOXIC. A NEW APPROACH TO TREATING BRAIN CANCER. MEDULLOBLASTOMA IS THE MOST COMMON MALIGNANT BRAIN CANCER IN CHILDREN. ALTHOUGH MANY PATIENTS CAN BE CURED WITH SURGERY, RADIATION, AND HIGH-DOSE CHEMOTHERAPY, SURVIVORS OFTEN SUFFER SEVERE LONG-TERM SIDE EFFECTS SUCH AS COGNITIVE AND DEVELOPMENTAL DISABILITIES DUE TO THE AGGRESSIVE TREATMENT. A RESEARCH TEAM LED BY DR. ROBERT WECHSLER-REYA DEVELOPED A NEW EXPERIMENTAL APPROACH TO TREATING MEDULLOBLASTOMA BY TARGETING CANCER STEM CELLS-THE CELLS THAT ARE CRITICAL FOR MAINTAINING TUMOR GROWTH. THE FINDINGS, DESCRIBED IN A RECENT PAPER IN "CANCER RESEARCH," STRONGLY SUPPORT THE NOTION OF COMBINING CONVENTIONAL CHEMOTHERAPY WITH CELL-CYCLE INHIBITORS TO IMPROVE THE EFFECTIVENESS OF THERAPY FOR MEDULLOBLASTOMA PATIENTS. DIABETES, OBESITY AND CARDIOVASCULAR RESEARCH DIFFERENCES BETWEEN "MARATHON MICE" AND "COUCH POTATO MICE" REVEAL KEY TO MUSCLE FITNESS. DR. DANIEL KELLY AND COLLEAGUES DISCOVERED THAT SMALL PIECES OF GENETIC MATERIAL CALLED MICRORNAS LINK THE TWO DEFINING CHARACTERISTICS OF FIT MUSCLES: THE ABILITY TO BURN SUGAR AND FAT, AND THE SWITCH BETWEEN SLOW- AND FAST-TWITCH MUSCLE FIBERS. THE TEAM USED TWO COMPLEMENTARY MOUSE MODELS-THE "MARATHON MOUSE" AND THE "COUCH POTATO MOUSE"-TO MAKE THIS DISCOVERY. THE FINDINGS, PUBLISHED IN "THE JOURNAL OF CLINICAL INVESTIGATION," SUGGEST MICRORNAS COULD BE TARGETED FOR THE DEVELOPMENT OF NEW MEDICAL INTERVENTIONS AIMED AT IMPROVING MUSCLE FITNESS IN PEOPLE WITH CHRONIC ILLNESS OR INJURY. PROGRESS TOWARD A CURE FOR DIABETES. IN BOTH TYPE 1 AND TYPE 2 DIABETES, LOSS OF THE PANCREATIC BETA-CELLS THAT PRODUCE INSULIN IN RESPONSE TO GLUCOSE IS A CRITICAL FEATURE OF THE DISEASE. IN TWO PAPERS PUBLISHED IN THE JOURNAL "STEM CELLS," DR. FRED LEVINE'S LAB DEMONSTRATES PROGRESS TOWARD CREATING FUNCTIONAL BETA CELLS. IN THE FIRST PAPER, THEY DEVELOPED A NEW MODEL OF RECONSTITUTING A NORMAL MASS OF FUNCTIONAL BETA CELLS IN MICE WHERE ALMOST ALL BETA CELLS HAD BEEN ELIMINATED. IN THEIR SECOND PAPER, THEY SHOW THAT A DRUG THEY DEVELOPED POTENTLY INDUCES BETA CELLS TO REPLICATE. THEY ARE WORKING ON A DRUG THAT CAN INDUCE BETA-CELL NEOGENESIS THAT, WHEN COMBINED WITH THE DRUG THAT INDUCES BETA-CELL REPLICATION, WILL PROVIDE A POTENT MIX TO INDUCE THE RECOVERY OF A NORMAL BETA-CELL MASS IN DIABETIC PATIENTS. FULL VISIBILITY OF NOVEL FACTORS IMPORTANT FOR INSULIN SECRETION. DR. PAMELA ITKIN-ANSARI AND COLLABORATORS AT THE SCRIPPS RESEARCH INSTITUTE HAVE REPORTED THE FIRST COMPREHENSIVE MAP OF THE PROTEIN INTERACTIONS THAT ENABLED CELLS IN THE PANCREAS TO PRODUCE, STORE, AND SECRETE INSULIN. THE MAP, CALLED AN "INSULIN-INTERACTOME" MAP, PROVIDES FULL VISIBILITY OF THE INTRICACIES OF THE INSULIN-SECRETION PROCESS. THE STUDY, PUBLISHED IN "CELL REPORT," HAS ALREADY YIELDED NOVEL FINDINGS, INCLUDING THE KEY ROLE OF A PROTEIN CALLED TMEM. THE STUDY IS IMPORTANT BECAUSE IT PROVIDES A DEEPER SCIENTIFIC UNDERSTANDING OF THE INSULIN-SECRETION PROCESS, WHICH MAY YIELD NEW TARGETS FOR THERAPEUTIC INTERVENTION IN DIABETES. NEW OBESITY DRUG REDUCES "BAD" BELLY FAT. BELLY FAT, ALSO CALLED VISCERAL FAT, IS LINKED TO AN INCREASED RISK OF HEART DISEASE, DIABETES, AND STROKE. IN A PAPER PUBLISHED IN "DIABETES, OBESITY AND METABOLISM," DR. STEVEN SMITH AND HIS COLLABORATORS TESTED WHETHER A NEW OBESITY DRUG IN LATE STAGE CLINICAL TESTING CALLED "CONTRAVE" MIGHT REDUCE "BAD" ABDOMINAL FAT. "BAD" FAT IS ASSOCIATED WITH COMPLICATIONS OF OBESITY SUCH AS DIABETES AND CARDIOVASCULAR DISEASE. THEY FOUND THAT THE DRUG, IN COMBINATION WITH OTHER THERAPIES, DECREASED "BAD" FAT, WITH SOME PATIENTS SHOWING UP TO A 40 PERCENT REDUCTION. CONTRAVE IS NOW BEING TESTED IN A LARGE MULTI-CENTER STUDY FOR ITS AFFECT ON CARDIOVASCULAR EVENTS, SUCH AS HEART ATTACKS. DISCOVERY OF A NEW MECHANISM LEADING TO ATHEROSCLEROSIS. IN A PAPER PUBLISHED IN "ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY," DR. DWIGHT TOWLER AND COLLEAGUES DESCRIBED A PATHWAY THAT LEADS TO HARDENING OF ARTERIES (ATHEROSCLEROSIS). THIS WORK ZEROED IN ON A PARTICULARLY DELETERIOUS PROTEIN CALLED DKK1. WHEN FUNCTIONING NORMALLY, DKK1 IS IMPORTANT FOR AIDING IN WOUND REPAIR. BUT INFLAMMATORY RESPONSES TRIGGERED INSIDE ARTERY WALLS ASSOCIATED WITH DISEASES LIKE DIABETES CAN TRIGGER PROLONGED AND DESTRUCTIVE DKK1 ACTIVITY. TOWLER AND HIS TEAM WILL CONTINUE TO STUDY DKK1 TO IDENTIFY POTENTIAL DRUG TARGETS TO PREVENT HARDENING OF ARTERIES IN PATIENTS WITH ATHEROSCLEROSIS.
PROGRAM SERVICE ACCOMPLISHMENTS CONTINUED   PATIENTS' OWN SKIN CELLS ARE TRANSFORMED INTO HEART CELLS TO CREATE "DISEASE IN A DISH." MOST PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULARDYSPLASIA/CARDIOMYOPATHY (ARVD/C) DON'T KNOW THEY HAVE A PROBLEM UNTIL THEY'RE IN THEIR EARLY20S-WHEN THEY'RE DIAGNOSED AT ADVANCED STAGES OR AFTER SUDDEN DEATH. A TECHNIQUE CALLED "DISEASE IN A DISH" MIGHT BRING NEW HOPE TO ARVD/C PATIENTS. DR. HUEI-SHENG VINCENT CHEN AND HIS TEAM RECENTLY TOOK SKIN SAMPLES FROM TWO ARVD/C PATIENTS. THEN, USING STEM CELL-BASED TECHNOLOGY THAT GARNERED A 2012 NOBEL PRIZE, THEY CONVERTED THE SKIN CELLS INTO HEART CELLS. IN A PAPER PUBLISHED IN "NATURE," THE RESEARCHERS UNVEILED THE FIRST MATURATION-BASED "DISEASE IN A DISH" MODEL FOR ARVD/C. THE MODEL WAS CREATED IN COLLABORATION WITH DR. DANIEL KELLY, AND IS LIKELY MORE RELEVANT TO HUMAN ARVD/C THAN OTHER MODELS AND BETTER SUITED FOR STUDYING THE DISEASE AND TESTING NEW TREATMENTS. INFECTIOUS AND INFLAMMATORY DISEASE THWARTING INFLAMMATION. VIRUSES HAVE EVOLVED TO EVADE THE IMMUNE SYSTEM, WHICH IS WHY THEY CAUSE INFECTIONS. HOWEVER, SOME VIRUSES, LIKE THE SMALLPOX VIRUS (NOW ERADICATED WORLDWIDE), HAVE MANY TRICKS TO THWART THE IMMUNE SYSTEM. A STUDY FROM DRS. REED'S AND LIDDINGTON'S LABORATORIES DEMONSTRATED HOW VACCINIA VIRUS, THE VACCINE STRAIN USED AGAINST SMALL-POX VIRUS, SUPPRESSES INFLAMMATION. PUBLISHED IN "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE," THE RESULTS DEMONSTRATE A VIRAL PROTEIN CALLED F1L THWARTS INFLAMMATION BY ALTERING A KEY HOST FACTOR KNOWN AS NLRP1. INTERESTINGLY, A SMALL PEPTIDE FROM F1L BLOCKS INFLAMMATION, SUGGESTING IT MAY HAVE POTENTIAL AS A DRUG TO TREAT ARTHRITIC CONDITIONS. PREVENTING AUTOIMMUNE DISEASES. B-CELL PRODUCTION IN BONE MARROW GENERATES A VAST REPERTOIRE OF ANTIBODY-PRODUCING CELLS THAT COLLECTIVELY RECOGNIZE VIRTUALLY ANY FOREIGN ENTITY, INCLUDING PATHOGEN COMPONENTS-BUT IT CAN ALSO PRODUCES B CELLS THAT IN TURN PRODUCE AUTOANTIBODIES THAT CAN RECOGNIZE "SELF-ANTIGENS," LEADING TO AUTOIMMUNE DISEASES. IN THE "JOURNAL OF IMMUNOLOGY," DR. ROBERT RICKERT'S LAB INVESTIGATED THE CELLULAR PROCESSES THAT CONTROL B-CELL TOLERANCE, WHICH PREVENTS B CELLS FROM PRODUCING ANTIBODIES TO SELF-ANTIGENS. THEY DEVELOPED A NOVEL MODEL TO SHOW THAT FOLLICULAR DENDRITIC CELLS (FDCS) KEY TO ELIMINATING AUTO-REACTIVE B CELLS TO SELF-ANTIGENS. THE FINDINGS PROVIDE A NEW PERSPECTIVE ON HOW AUTOIMMUNE DISEASE MAY BE PREVENTED. THE RESEARCH WAS RECENTLY RECOGNIZED TO BE OF SPECIAL SIGNIFICANCE BY THE FACULTY OF 1000. ONE IN A MILLION. THE IMMUNE SYSTEM PROTECTS US AGAINST INFECTIONS. BUT, SOMETIMES IT TURNS AGAINST US CAUSING AUTOIMMUNE DISEASE. IN RHEUMATOID ARTHRITIS, IMMUNE CELLS TERMED LYMPHOCYTES, SECRETE TNF (TUMOR NECROSIS FACTOR), A PROTEIN THAT CAN PROMOTE DESTRUCTION OF THE JOINTS, CAUSING PAIN AND SEVERE BONE EROSION. ANTI-TNF THERAPY IS SUCCESSFULLY TREATS SOME PATIENTS WITH AUTOIMMUNE DISEASE. IN THE "JOURNAL OF IMMUNOLOGY," DRS. CARL WARE AND SALVO ALBANI REPORT ON AN ATYPICAL LYMPHOCYTE THAT CONTINUOUSLY SECRETES TNF DETECTED AT ABOUT ONE IN A MILLION CELLS IN THE BLOOD OF NORMAL PEOPLE. THESE ATYPICAL LYMPHOCYTES ARE DRAMATICALLY INCREASED IN THE BLOOD OF PATIENTS WITH RHEUMATOID ARTHRITIS. THEIR GOAL IS TO UNDERSTAND WHY THESE CELLS ARE ELEVATED IN AUTOIMMUNE DISEASE. NEUROSCIENCE, AGING AND STEM CELL RESEARCH NOVEL DRUG REVERSES LOSS OF BRAIN CONNECTIONS IN MODELS OF ALZHEIMER'S. DR. STUART LIPTON AND HIS TEAM HAVE DEVELOPED THE FIRST EXPERIMENTAL DRUG TO BOOST BRAIN SYNAPSES LOST IN ALZHEIMER'S DISEASE. THE DRUG, NITROMEMANTINE, COMBINES TWO FDA-APPROVED MEDICINES, NITROGLYCERIN AND MEMANTINE, INTO A NOVEL SINGLE AGENT. TOGETHER, THEY STOP THE DESTRUCTIVE CASCADE OF CHANGES IN THE BRAIN THAT DESTROYS THE CONNECTIONS BETWEEN NEURONS, LEADING TO MEMORY LOSS AND COGNITIVE DECLINE. THE RESEARCH, PUBLISHED IN "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES," FOCUSES ON A DOWNSTREAM TARGET TO TREAT ALZHEIMER'S, RATHER THAN ON AMYLOID BETA PLAQUES AND NEUROFIBRILLARY TANGLES-APPROACHES THAT HAVE SHOWN LITTLE SUCCESS IN THE PAST. UNRAVELING THE MOLECULAR ROOTS OF DOWN SYNDROME. DR. HUAXI XU'S LABORATORY HAS FOUND THAT PROTEIN CALLED SORTING NEXIN 27, OR SNX27, IS REDUCED IN HUMAN DOWN SYNDROME BRAINS. THE STUDY, PUBLISHED IN "NATURE MEDICINE," SHOWS THAT SNX27 HELPS KEEP GLUTAMATE RECEPTORS ON THE CELL SURFACE IN NEURONS. NEURONS NEED GLUTAMATE RECEPTORS IN ORDER TO FUNCTION CORRECTLY. WITH LESS SNX27, MICE HAD FEWER ACTIVE GLUTAMATE RECEPTORS AND THUS IMPAIRED LEARNING AND MEMORY. FURTHER STUDY REVEALED THAT CHROMOSOME 21 ENCODES ONE PARTICULAR MICRORNA CALLED MIR-155. IN HUMAN DOWN SYNDROME BRAINS, THE INCREASE IN MIR-155 LEVELS CORRELATES ALMOST PERFECTLY WITH THE DECREASE IN SNX27. THROUGH THIS MECHANISM, LEARNING, MEMORY, AND BEHAVIOR ARE IMPAIRED. TRANSPLANTED NEURAL STEM CELLS TREAT ALS IN MOUSE MODEL. AMYOTROPHIC LATERAL SCLEROSIS (ALS), ALSO KNOWN AS LOU GEHRIG'S DISEASE, IS UNTREATABLE AND FATAL. A CONSORTIUM OF ALS RESEARCHERS AT MULTIPLE INSTITUTIONS, LED BY DR. EVAN SNYDER, TESTED TRANSPLANTED NEURAL STEM CELLS AS A TREATMENT FOR THE DISEASE. IN 11 INDEPENDENT STUDIES, THEY FOUND THAT TRANSPLANTING NEURAL STEM CELLS INTO THE SPINAL CORD OF A MOUSE MODEL OF ALS SLOWS DISEASE ONSET AND PROGRESSION. THE NEURAL STEM CELLS HELP BY PRODUCING FACTORS THAT PRESERVE THE HEALTH AND FUNCTION OF THE HOST'S REMAINING NERVE CELLS. THESE FINDINGS, PUBLISHED IN "SCIENCE TRANSLATIONAL MEDICINE," DEMONSTRATE THE POTENTIAL NEURAL STEM CELLS HOLD FOR TREATING ALS AND OTHER NERVOUS SYSTEM DISORDERS. A KEY PROTEIN THAT MODULATES ORGANISMAL AGING. A STUDY DIRECTED BY DR. MALENE HANSEN IDENTIFIED A KEY FACTOR THAT REGULATES THE AUTOPHAGY PROCESS WHERE CELLULAR DEBRIS IS DIGESTED TO PROTECT CELLS FROM DAMAGE, AND WHICH IN TURN MODULATES AGING. HER LAB AND COLLABORATORS IDENTIFIED A TRANSCRIPTION FACTOR - AN ON/OFF SWITCH FOR GENES - CALLED HLH-30 THAT INDUCES AUTOPHAGY IN MODEL ORGANISMS, INCLUDING THE WORM C. ELEGANS. SINCE A SIMILAR TRANSCRIPTION FACTOR, TFEB, REGULATES AUTOPHAGY IN MAMMALIAN CELLS, THESE FINDINGS, PUBLISHED IN "NATURE COMMUNICATIONS," COULD LEAD TO THE DEVELOPMENT OF NEW THERAPIES FOR AGE-RELATED DISORDERS THAT ARE CHARACTERIZED BY A BREAKDOWN IN THIS PROCESS, FOR EXAMPLE, IN NEURODEGENERATIVE AND CARDIOVASCULAR DISEASES. CHILDREN'S HEALTH DISCOVERING AN ORAL DRUG TO PREVENT METABOLIC SYNDROME. DR. JOS LUIS MILLN'S LABORATORY AND COLLABORATORS AT MASSACHUSETTS GENERAL HOSPITAL AND HARVARD MEDICAL SCHOOL HAVE ADVANCED STUDIES SHOWING THAT ORAL ADMINISTRATION OF INTESTINAL ALKALINE PHOSPHATASE (IAP)-A GUT MUCOSAL DEFENSE FACTOR IS BENEFICIAL IN MOUSE MODELS OF CHRONIC COLITIS. IN "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES," THE RESEARCHERS NOW SHOW THAT ORAL ADMINISTRATION OF IAP INHIBITS THE ABSORPTION OF LIPOPOLYSACCHARIDES, A MAJOR COMPONENT OF THE OUTER MEMBRANE OF BACTERIA. THE ABSORPTION OF LIPOPOLYSACCHARIDES OCCURS IN TANDEM WITH THE ABSORPTION OF DIETARY FAT. IAP, THEREFORE, IMPROVES THE LIPID PROFILE IN MICE THAT ARE FED A STANDARD, LOW-FAT DIET. THE FINDINGS MAY LEAD TO NEW WAYS TO PREVENT THE ONSET OF METABOLIC SYNDROME, A PRE-DIABETIC CONDITION. A NEW APPROACH TO PREVENTING LIVER FAILURE IN CHILDREN. WHEN CELL PROTEINS ARE MISFOLDED, THEY AGGREGATE IN THE CELL AND CAUSE CELL DEATH. IN A REPORT PUBLISHED IN "MOLECULAR BIOLOGY OF THE CELL," DR. RANDAL KAUFMAN'S LAB DESCRIBED HOW THE ENZYME "UGGT1" IS REQUIRED TO PREVENT PROTEIN AGGREGATION. THE UGGT1 ENZYME, CODED FOR BY A GENE THAT WAS FIRST ISOLATED BY KAUFMAN YEARS AGO, WAS INITIALLY THOUGHT TO PREVENT THE RELEASE OF MISFOLDED PROTEINS FROM THE ENDOPLASMIC RETICULUM. THE CURRENT STUDY USED MUTANT FORMS OF THE ?1-ANTITRYPSIN (?1-AT) LIVER PROTEIN TO SHOW THAT UGGT1 ACTUALLY PREVENTS AGGREGATION. SINCE MUTATIONS IN THE ?1-AT GENE THAT CAUSE PROTEIN AGGREGATION ARE THE MOST COMMON CAUSE OF LIVER FAILURE IN CHILDREN, THESE FINDINGS MAY GUIDE AVENUES TO TREAT AND/OR PREVENT THE MOST COMMON DEVASTATING LIVER DISEASE IN CHILDREN. GENOME-SEQUENCING DIAGNOSTICS FOR RARE DISEASES: A CAUTIONARY TALE. PROPERLY DIAGNOSING A CHILD BORN WITH CONGENITAL DISORDERS OF GLYCOSYLATION, OR CDG, AND PINPOINTING THE EXACT SUGAR GENE THAT'S MUTATED PROVIDES DOCTORS WITH USEFUL INFORMATION TO DEVELOP A THERAPEUTIC APPROACH. WHOLE-EXOME SEQUENCING, AN ABBREVIATED FORM OF WHOLE-GENOME SEQUENCING, IS INCREASINGLY USED AS A DIAGNOSTIC FOR CDG. BUT RESEARCHERS LED BY DR. HUDSON FREEZE RECENTLY DISCOVERED THREE CHILDREN WITH CDG WHO ARE MOSAICS-ONLY SOME CELLS IN SOME TISSUES HAVE THE MUTATION. FOR THAT REASON, STANDARD EXOME SEQUENCING INITIALLY MISSED THEIR MUTATIONS, HIGHLIGHTING THE TECHNIQUE'S DIAGNOSTIC LIMITATIONS IN SOME RARE CASES. THESE FINDINGS WERE PUBLISHED IN THE "AMERICAN JOURNAL OF HUMAN GENETICS."
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For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2012

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