Department of the Treasury Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
Attach to Form 990 or Form 990-EZ. See separate instructions. Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
THE HAMNER INSTITUTES FOR HEALTH SCIENCE
Employer identification number
20-3692587
Part I
Reason for Public Charity Status
(All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
By checking this box, I certify that the organization is not controlled directly or indirectly by one or more disqualified persons other than foundation managers and other than one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2).
f
If the organization received a written determination from the IRS that it is a Type I, Type II, or Type III supporting organization, check this box
..................................................
g
Since August 17, 2006, has the organization accepted any gift or contribution from any of the following persons?
(i) A person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the supported organization?
................
11g(i)
(ii)
A family member of a person described in (i) above?
......................
11g(ii)
(iii)
A 35% controlled entity of a person described in (i) or (ii) above?
................
11g(iii)
h
Provide the following information about the supported organization(s).
(i) Name of supported organization
(ii) EIN
(iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions))
(iv) Is the organization in col. (i) listed in your governing document?
(v) Did you notify the organization in col. (i) of your support?
(vi) Is the organization in col. (i) organized in the U.S.?
(vii) Amount of monetary support
Yes
No
Yes
No
Yes
No
Total
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi) (Complete only if you checked the box on line 5, 7, or 8 of Part I or if the
organization failed to qualify under Part III. If the organization fails to
qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in)
(a) 2009
(b) 2010
(c) 2011
(d) 2012
(e) 2013
(f) Total
1
Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....
14,255,024
16,526,435
12,495,973
12,253,096
12,110,077
67,640,605
2
Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......
3
The value of services or facilities furnished by a governmental unit to the organization without charge..
4
Total. Add lines 1 through 3
14,255,024
16,526,435
12,495,973
12,253,096
12,110,077
67,640,605
5
The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included
on line 1 that exceeds 2% of the amount shown on line 11, column (f)..
18,812,930
6
Public support. Subtract line 5 from line 4.
48,827,675
Section B. Total Support
Calendar year
(or fiscal year beginning in)
(a) 2009
(b) 2010
(c) 2011
(d) 2012
(e) 2013
(f) Total
7
Amounts from line 4..
14,255,024
16,526,435
12,495,973
12,253,096
12,110,077
67,640,605
8
Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...
285,043
115,592
52,754
68,767
780,822
1,302,978
9
Net income from unrelated business activities, whether or not the business is regularly carried on..
10
Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)..
77,447
68,147
108,536
233,817
510,879
998,826
11
Total support (Add lines 7 through 10).
69,942,409
12
Gross receipts from related activities, etc. (see instructions)
..................
12
13
First five years.
If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization,
check this box and stop here.................................................
Section C. Computation of Public Support Percentage
14
Public support percentage for 2013 (line 6, column (f) divided by line 11, column (f))
.........
14
69.810 %
15
Public support percentage for 2012 Schedule A, Part II, line 14
...............
15
65.140 %
16a
33 1/3% support test—2013.
If the organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box
and stop here. The organization qualifies as a publicly supported organization
.......................
b
33 1/3% support test—2012.
If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization
.....................
17a
10%-facts-and-circumstances test—2013.
If the organization did not check a box on line 13, 16a, or 16b, and line 14
is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain
in Part IV how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported
organization
.....................................................
b
10%-facts-and-circumstances test—2012.
If the organization did not check a box on line 13, 16a, 16b, or 17a, and line
15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here.
Explain in Part IV how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported organization
................................................
18
Private foundation.
If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions
.....................................................
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2) (Complete only if you checked the box on line 9 of Part I or if the organization
failed to qualify under Part II. If the organization fails to qualify under
the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in)
(a) 2009
(b) 2010
(c) 2011
(d) 2012
(e) 2013
(f) Total
1
Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .
2
Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......
3
Gross receipts from activities that are not an unrelated trade or business under section 513..
4
Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5
The value of services or facilities furnished by a governmental unit to the organization without charge..
6
Total. Add lines 1 through 5.
7a
Amounts included on lines 1, 2, and 3 received from disqualified persons...
b
Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.
c
Add lines 7a and 7b..
8
Public support (Subtract line 7c from line 6.)
Section B. Total Support
Calendar year (or fiscal year beginning in)
(a) 2009
(b) 2010
(c) 2011
(d) 2012
(e) 2013
(f) Total
9
Amounts from line 6...
10a
Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
b
Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.
c
Add lines 10a and 10b.
11
Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.
12
Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)
..
13
Total support. (Add lines 9, 10c, 11, and 12.)..
14
First five years.
If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization,
check this box and stop here.............................................
Section C. Computation of Public Support Percentage
15
Public support percentage for 2013 (line 8, column (f) divided by line 13, column (f))
.........
15
16
Public support percentage from 2012 Schedule A, Part III, line 15
...............
16
Section D. Computation of Investment Income Percentage
17
Investment income percentage for 2013 (line 10c, column (f) divided by line 13, column (f))
......
17
18
Investment income percentage from 2012 Schedule A, Part III, line 17
.............
18
19a
33 1/3% support tests—2013.
If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization
........
b
33 1/3% support tests—2012.
If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization
.....
20
Private foundation.
If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions
.....
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 4
Part IV
Supplemental Information.
Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; and Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
Explanation
Schedule A (Form 990 or 990-EZ) 2013
Additional Data
Software ID:
Software Version:
-
TIN:
SCHEDULE O (Form 990 or 990-EZ)
Department of the Treasury Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ
Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
Attach to Form 990 or 990-EZ.
Information about Schedule O (Form 990 or 990-EZ) and its instructions is at
www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
THE HAMNER INSTITUTES FOR HEALTH SCIENCE
Employer identification number
20-3692587
Return Reference
Explanation
FORM 990, PART VI, SECTION B, LINE 11
A COPY OF THE FORM 990 WAS REVIEWED BY THE FINANCE COMMITTEE. AFTERWARDS THE FORM 990 WAS REVEIWED WITH THE BOARD PRIOR TO FILING.
FORM 990, PART VI, SECTION B, LINE 12C
THE BOARD MAINTAINS A CONFLICT OF INTEREST POLICY WHICH IS SIGNED ON AN ANNUAL BASIS. IN THE COURSE OF MEETINGS OR ACTIVITIES, EVERYONE WILL DISCLOSE ANY INTERESTS IN A TRANSACTION OR DECISION WHERE HE/SHE (INCLUDING THEIR BUSINESS OR OTHER NON-PROFIT AFFILIATIONS, FAMILY AND/OR SIGNIFICANT OTHER, EMPLOYER OR CLOSE ASSOCIATES) MAY HAVE A CONFLICT. AFTER DISCLOSURE OF ANY POSSIBLE CONFLICT OF INTEREST, THE PERSON WILL BE ASKED TO LEAVE THE ROOM FOR THE DISCUSSION AND WILL NOT BE PERMITTED TO VOTE ON THE QUESTION.
FORM 990, PART VI, SECTION B, LINE 15
HUMAN RESOURCES PREPARES MARKET ANALYSIS OF SALARY SURVEY AND OTHER DATA TO PROVIDE RECOMMENDATIONS TO THE INDEPENDENT COMPENSATION COMMITTEE, WHO REVIEWS THESE DATA ALONG WITH PERFORMANCE EVALUATIONS TO APPROVE ANY SALARY ADJUSTMENTS.
FORM 990, PART VI, SECTION C, LINE 18
THE ORGANIZATION'S FORM 990 IS MADE AVAILABLE TO THE PUBLIC UPON REQUEST AND ON WWW.GUIDESTAR.ORG.
FORM 990, PART VI, SECTION C, LINE 19
THE GOVERNING DOCUMENTS, CONFLICT OF INTEREST STATEMENT, AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST.
FORM 990, PART XII, LINE 2C:
THIS PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR.
FORM 990, PART III, LINE 4A:
IN FEBRUARY 2013, THE HAMNER INSTITUTES FOR HEALTH SCIENCES (THE HAMNER), A NONPROFIT RESEARCH ORGANIZATION FOCUSED ON TRANSLATIONAL SAFETY SCIENCES, AND QPS HOLDINGS, LLC, A NEWARK, DELAWARE USA HEADQUARTERED GLOBAL CONTRACT RESEARCH ORGANIZATION (CRO), ANNOUNCED THE LAUNCH OF QPS HEPATIC BIOSCIENCES, A CENTER OF EXCELLENCE FOR CELL BASED RESEARCH AND SERVICES. HEPATIC BIOSCIENCES WAS ESTABLISHED AS A NEW DIVISION WITHIN THE QPS DMPK DEPARTMENT AND SPECIALIZES IN HEPATOCYTE RESEARCH, DRUG METABOLISM, DRUG TRANSPORTER SCIENCES, AND IN VITRO DRUG-DRUG INTERACTIONS. THE SCIENTIFIC DISCIPLINE OF THE OPERATION AT THE HAMNER INSTITUTES IS JOINTLY LED BY DRS. EDWARD LECLUYSE, ASSOCIATE INVESTIGATOR AT THE HAMNER, AND CAROLINE LEE, DIRECTOR OF DRUG METABOLISM AND TRANSPORTER SCIENCES AT QPS. HEPATIC BIOSCIENCES ALSO ASSUMED RESPONSIBILITY FOR ALL GLP-COMPLIANT QUALITY ASSURANCE AND BIOANALYSIS IN SUPPORT OF THE HAMNER. IN ADDITION TO AUGMENTING EXISTING HAMNER RESEARCH PROGRAMS, QPS WILL FOCUS ON NEW BUSINESS DEVELOPMENT FOR BOTH ORGANIZATIONS. ADDITIONALLY IN FEBRUARY 2013, THE HAMNER ANNOUNCED THEIR PARTNERSHIP WITH MISPRO BIOTECH SERVICES, A LEADING PROVIDER OF MULTI-USER VIVARIUM SPACE AND REMOTE HUSBANDRY SERVICES. AS PART OF THIS NEW PARTNERSHIP, MISPRO NOW OPERATES A 10,000 SQUARE-FOOT VIVARIUM - ITS FIRST IN THE REGION - AT THE HAMNER INSTITUTES. MISPRO'S STATE-OF-THE-ART ANIMAL HUSBANDRY FACILITIES FEATURE STATIC OR VENTILATED CAGES WITH IN-ROOM CLASS II BIOLOGICAL SAFETY CABINETS, DEDICATED OFFICES AND PROCEDURE ROOMS, A QUARANTINE FACILITY, 24/7 ACCESS, ENVIRONMENTAL MONITORING, ANIMAL IMPORT AND EXPORT SERVICES, AND PROTOCOL REVIEW BY MISPRO'S INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC). IN APRIL 2013, THE HAMNER ANNOUNCED THAT ITS SCIENTISTS HAD BEEN RECOGNIZED WITH 12 AWARDS FROM THE SOCIETY OF TOXICOLOGY (SOT), A PROFESSIONAL ORGANIZATION COMMITTED TO CREATING A SAFER AND HEALTHIER WORLD BY ADVANCING THE SCIENCE OF TOXICOLOGY, AT THE GROUP'S 52ND ANNUAL MEETING HELD MARCH 10-14 IN SAN ANTONIO, TEXAS. THE HONORS FOLLOWED AN IMPRESSIVE PRESENCE AT THE MEETING THAT CONSISTED OF NEARLY 50 PRESENTATIONS BY HAMNER SCIENTISTS. IN TOTAL, 14 INSTITUTE SCIENTISTS WERE RECOGNIZED FOR THEIR CONTRIBUTIONS TO VARIOUS TOP ABSTRACTS, POSTERS, AND PAPERS ENCOMPASSING WORK PERFORMED OVER THE LAST YEAR. FOR A COMPLETE LIST OF THE HAMNER'S AWARDS AT SOT, PLEASE VISIT: HTTP://GOO.GL/CAJ6E. ALSO IN APRIL 2013, THE HAMNER ANNOUNCED THE LATEST RELEASE OF ITS FLAGSHIP DILI (DRUG-INDUCED LIVERY INJURY) PLATFORM - DILISYM SOFTWARE - VERSION 2A. DILISYM SOFTWARE IS DEVELOPED AND RELEASED AS PART OF THE DILI-SIM INITIATIVE (WWW.DILISYM.COM), AN EFFORT TO DEVELOP A MATHEMATICAL, MECHANISTIC MODEL OF DRUG-INDUCED LIVER INJURY CHAIRED BY DR. PAUL B. WATKINS. DILISYM V2A WAS MADE AVAILABLE TO ALL DILI-SIM INITIATIVE INDUSTRY MEMBERS AS OF APRIL 10TH, 2013. A MID-YEAR UPDATE, DILISYM V2B, WAS MADE AVAILABLE IN JULY 2013, AS WELL AS THE LAUNCH OF A NEW COMPUTATIONAL MODEL OF MITOCHONDRIAL FUNCTION, MITOSYM SOFTWARE. IN JULY 2013, IT WAS ANNOUNCED THAT HAMNER SCIENTISTS WOULD BE COLLABORATING ON A $14.1 MILLION INITIATIVE LED BY RESEARCHERS AT MICHIGAN STATE UNIVERSITY TO BETTER UNDERSTAND HOW ENVIRONMENTAL CONTAMINANTS CALLED DIOXINS AFFECT HUMAN HEALTH AND TO IDENTIFY NEW WAYS OF REMOVING THEM FROM THE ENVIRONMENT. THE RESEARCHERS WILL USE A FIVE-YEAR GRANT FROM THE SUPERFUND RESEARCH PROGRAM OF THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES TO SUPPORT MULTIPLE STUDIES ON THE INDUSTRIAL BYPRODUCTS, WHICH WORK THEIR WAY UP THE FOOD CHAIN TO HUMANS, POTENTIALLY RAISING THE RISK OF CERTAIN CANCERS AND OTHER DISEASES. IN AUGUST 2013, HEPREGEN CORPORATION, DEVELOPER OF NEXT GENERATION HEPATOPACTM AND HEPATOMUNETM PRODUCTS, AND THE HAMNER ANNOUNCED THE INITIATION OF A RESEARCH PARTNERSHIP THAT PROVIDES THE OPPORTUNITY TO COLLABORATE ON RESEARCH SUPPORTING NEXT GENERATION IN VITRO MICRO-LIVER ANALYSIS ASSOCIATED WITH PHARMACEUTICAL AND CHEMICAL PRODUCT DEVELOPMENT. THE RESEARCH EFFORT IS LED BY DR. EDWARD LECLUYSE, ASSOCIATE INVESTIGATOR AT THE HAMNER, AND DR. MICHAEL HOLSAPPLE, VICE PRESIDENT OF TOXICOLOGY PRODUCT DEVELOPMENT AT HEPREGEN, ALONG WITH MR. JACK MCGEEHAN, HEPREGEN'S VICE PRESIDENT OF OPERATIONS. THE PARTNERSHIP WILL FOCUS ON RESEARCH AND DEVELOPMENT EFFORTS AIMED AT DEFINING: (1) BASIC CONCEPTS REGARDING THE POTENTIAL FOR NEW MICRO-LIVER PRODUCTS AND (2) NEW APPLICATIONS AND ASSAY METHODOLOGIES FOR HEPREGEN'S EXISTING MICRO-LIVER PRODUCTS THAT ARE ALREADY TRANSFORMING PHARMACEUTICAL PRODUCT DEVELOPMENT. IN SEPTEMBER 2013, IN ALIGNMENT WITH ITS VISION AND COMMITMENT TO TRANSLATIONAL LIFE SCIENCES TRAINING, THE HAMNER INSTRUCTED A ONE WEEK COURSE FOR OVER 25 PARTICIPANTS FROM MONDAY, SEPT. 16 THROUGH FRIDAY, SEPT. 20 THAT COVERED THE APPLICATION OF COMPUTATIONAL MODELING PARADIGMS TO HUMAN HEALTH ASSESSMENTS. THE COURSE FEATURED COMPREHENSIVE LECTURES AND EXTENSIVE HANDS-ON COMPUTER MODELING PRACTICE, AND WAS DESIGNED TO SERVE A VARIETY OF SCIENTIFIC COMMUNITIES, INCLUDING INDUSTRIAL, PHARMACEUTICAL AND REGULATORY SCIENTISTS, TOXICOLOGISTS AND RESEARCH SCIENTISTS, AND INDIVIDUALS INTERESTED IN PROMOTING THE USE OF ALTERNATIVES TO LIVE ANIMAL TESTING. IN NOVEMBER 2013, A HAMNER-LED TEAM OF SCIENTISTS PUBLISHED ON A NEW PARADIGM FOR INFORMED AND COST EFFICIENT TOXICITY TESTING IN THE JOURNAL, TOXICOLOGICAL SCIENCES. THE DATA-DRIVEN FRAMEWORK THAT IS PROPOSED IN THE ARTICLE PROVIDES A RISK-BASED AND ANIMAL-SPARING APPROACH TO EVALUATE CHEMICAL SAFETY, DRAWING BROADLY FROM PREVIOUS EXPERIENCE BUT INCORPORATING TECHNOLOGICAL ADVANCES TO INCREASE EFFICIENCY. IN DECEMBER 2013, THE HAMNER ANNOUNCED A COLLABORATIVE AGREEMENT WITH CELLULAR DYNAMICS INTERNATIONAL (CDI) TO DEVELOP PREDICTIVE IN VITRO SCREENING ASSAYS FOR CHEMICAL, ENVIRONMENTAL AND PHARMACEUTICAL TOXICOLOGY ASSESSMENTS THAT UTILIZE CDI'S HUMAN INDUCED PLURIPOTENT STEM (IPS) CELL-DERIVED HEPATOCYTES. THE COLLABORATION IS INTENDED TO ACCELERATE INNOVATIVE TOXICITY TESTING RESEARCH. UNDER THE AGREEMENT, CDI WILL PROVIDE ICELL HEPATOCYTES TO THE HAMNER FOR USE IN AN ON-GOING PROGRAM OF RESEARCH, REFERRED TO AS "TOXICITY TESTING IN THE 21ST CENTURY: TOXICITY PATHWAYS AND NETWORK BIOLOGY." THIS PROGRAM EMPLOYS SEVERAL PROTOTYPICAL TOXICITY PATHWAY CASE STUDIES TO DEVELOP HUMAN CELL-BASED ASSAYS THAT MAP AND MODEL KEY CELL SIGNALING PATHWAYS IN ORDER TO EVALUATE DOSE RESPONSE. THESE ASSAYS, ONCE VALIDATED WITH PROTOTYPE CHEMICALS, SHOULD ENABLE TOXICITY TESTING AND RISK ASSESSMENTS BASED SOLELY ON IN VITRO TEST RESULTS, WITHOUT PROGRESSING TO TOXICITY STUDIES IN INTACT ANIMALS. THESE IN VITRO-BASED TOXICITY TESTING SCHEMES WILL SPEED TESTING OF BOTH IMPORTANT COMPOUNDS IN COMMERCE AND NEW COMPOUNDS COMING INTO USE. MORE RAPID TESTING WILL ALSO HELP ASSESS THE BACKLOG OF THOUSANDS OF CHEMICALS FOR WHICH THERE IS VERY LIMITED TOXICITY TEST DATA. AS THESE TEST TECHNOLOGIES MATURE, THEY COULD ALSO PROVIDE A MEANS TO SPEED DRUG DISCOVERY BY PROVIDING ASSESSMENTS OF SAFETY FAR EARLIER IN THE DRUG DEVELOPMENT PROCESS.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.