Attach to Form 990 or Form 990-EZ.
See separate instructions.| (i) Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) | (iv) Is the organization in col. (i) listed in your governing document? | (v) Did you notify the organization in col. (i) of your support? | (vi) Is the organization in col. (i) organized in the U.S.? | (vii) Amount of monetary support | |||
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| Yes | No | Yes | No | Yes | No | ||||
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(a) 2008 | (b) 2009 | (c) 2010 | (d) 2011 | (e) 2012 | (f) Total | |
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| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .... | ||||||
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....... | ||||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 4 | Total. Add lines 1 through 3 | ||||||
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. | ||||||
| 6 | Public support. Subtract line 5 from line 4. | ||||||
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(a) 2008 | (b) 2009 | (c) 2010 | (d) 2011 | (e) 2012 | (f) Total | |
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| 7 | Amounts from line 4.. | ||||||
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | ||||||
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.).. | ||||||
| 11 | Total support (Add lines 7 through 10). | ||||||






Calendar year (or fiscal year beginning in) ![]() |
(a) 2008 | (b) 2009 | (c) 2010 | (d) 2011 | (e) 2012 | (f) Total | |
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| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose...... | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513.. | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 6 | Total. Add lines 1 through 5. | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons... | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support (Subtract line 7c from line 6.) | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2008 | (b) 2009 | (c) 2010 | (d) 2011 | (e) 2012 | (f) Total | |
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| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||




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Attach to Form 990 or 990-EZ.| Identifier | Return Reference | Explanation |
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| FORM 990, PART I, LINE 1 & PART III, LINE 1: | THE MASSACHUSETTS EYE AND EAR INFIRMARY ("THE INFIRMARY") IS A NOT-FOR-PROFIT TEACHING HOSPITAL CONDUCTING PATIENT CARE AND RESEARCH. THE INFIRMARY IS A TEACHING HOSPITAL OF HARVARD MEDICAL SCHOOL AND AN INTERNATIONAL CENTER FOR RESEARCH. IT HAS THE MOST COMPETITIVE PROGRAM IN THE COUNTRY FOR EYE, EAR, NOSE, AND THROAT RESIDENCY TRAINING AND THE WORLD'S LARGEST OPHTHALMIC FELLOWSHIP PROGRAM. IT IS PART OF A SYSTEM OF RELATED ENTITIES THAT PROVIDE SPECIALIZED MEDICAL CARE COLLECTIVELY KNOWN AS "MASSACHUSETTS EYE AND EAR INFIRMARY" ("MEEI"). | |
| FORM 990, PART III, LINE 4A: | RESEARCH | Ophthalmology: - A New, Complete Catalogue: Gene Expression in the Human Retina Published. Michael Farkas, PhD, Eric Pierce, MD, PhD, and investigators in the HMS Ophthalmology Ocular Genomics Institute (OGI) at Mass. Eye and Ear recently published the most thorough description of gene expression in the human retina (BMC Genomics, July 2013). According to researchers, documenting the entirety of these genetic data into a catalogue is crucial for understanding how diseases of the eye develop and lead to vision loss. Investigators used a technique called RNA sequencing (RNA-seq) to identify all of the messenger RNAs (mRNAs) produced in the human retina. This catalog of expressed genes, or transcriptome, revealed that the majority of the 20,000+ genes in the human body are expressed in the retina. The researchers also identified almost 30,000 novel exons (portions of the genome that are used to encode proteins or other genetic elements) and over 100 potential novel genes that had not been identified previously. To date, investigators have identified more than 200 retinal degeneration disease genes, but identification of new exons used in the retina may help find the cause of disease in currently undiagnosed patients. - First Corneal Transplant Performed With Pre-loaded Tissue. Roberto Pineda, II, MD performed a series of groundbreaking procedures in April 2013 when he utilized EndoGlide (Angiotech Pharmaceuticals, Inc.) cartridges pre-loaded at the Lions Eye Institute for Transplant & Research (LEITR) in Tampa, FL for endothelial keratoplasty transplant procedures at the Mass. Eye and Ear. Dr. Pineda utilized donor endothelial tissue that was pre-cut, trephined and pre-loaded into the devices before being sent to the Mass. Eye and Ear for transplantation. In 2012, the LEITR presented a pre-clinical study at the 2012 ARVO Annual Meeting reporting that eye banks are able to safely prepare and load corneal tissue into the EndoGlide cartridges. - Mass. Eye and Ear Joins Global Alliance to Share Genomic and Clinical Data. Massachusetts Eye and Ear is among the nearly 70 leading health care, research, and disease advocacy organizations that have joined together to form an international alliance dedicated to enabling secure sharing of genomic and clinical data. The alliance will support the formation of large, shared datasets that will allow researchers around the globe to identify target pathways and develop transformational therapies for patients. The group will develop methods and policies to share information responsibly, while protecting patient privacy and the public interest. Research Successes: - 238 Proposals - 88 Awards - Total grants awarded: $32,740,597 Retina: - Members of the Angiogenesis Laboratory investigated the mechanism of cell death in retinal degenerations and showed that RIP Kinase mediated programmed necrosis, not apoptosis, is a key mediator of photoreceptor cell loss and damage associated molecular pattern mediated inflammation in animal models of inherited retinal degenerations (IRD) and dry AMD. This can lead to novel therapeutics for dry AMD, IRD, and other retinal disorders. - Researchers from the Angiogenesis Laboratory examined the role of the energy sensor for the cell called AMPK and showed it to regulate vascular cell permeability and angiogenesis. This can lead to a new class of anti-leakage and anti-angiogenesis drugs. - Studied non-chemotherapy drugs for retinoblastoma and showed the role of a small activator of the metabolic and energy sensor AMPK in inhibiting retinoblastoma cell growth in vivo in an animal model. This could lead to gentler therapies for children with retinoblastoma. - Conducted clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. Showed that conjunctival large cell acanthoma is a morphologically distinctive clonal entity with clinical and immunohistochemical phenotypic characteristics denoting a dysplasia of minimal severity. Because of recurrences without invasion, it requires treatment. - Presented an improved technique of experimental retinal detachment in rodents that result in more reproducible results. - Showed that a simple non-invasive test can be used to monitor a rare inflammatory disease of the retina called ampiginous choroiditis. - Presented a comprehensive review on photoreceptor cell death pathways and neuroprotection strategies in Progress in Retina Eye Research. - Was a participating center in the Age-Related Eye Disease Study 2 (AREDS2), a large multicenter clinical trial funded by the National Eye Institute, which clarified the effectiveness of specific dietary supplement formulations for the treatment of AMD. - Provided pre-clinical evidence that ranibizumab, a vascular endothelial growth factor inhibitor, may prevent vitreoretinopathy (PVR), a serious complication that can occur after surgical repair of retinal detachment. - Demonstrated that converting patients with chronic neovascular AMD to aflibercept (Eylea) results in stabilized vision and improved anatomic outcomes, while allowing injection intervals to be extended. - Showed that CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration. - Demonstrated that AMD-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. |
| Ocular Genomics Institute (OGI): | - Inherited macular degeneration: In a study published in the journal Human Molecular Genetics, members of the OGI reported for the first time that that the complement system plays a critical role in the early stage of an inherited macular degeneration, in addition to being associated with age-related macular degeneration. This is important because it provides insight into how alterations in complement system components contribute to macular disease. - Human retinal transcriptome: Researchers from the group reported the most thorough description of gene expression in the human retina reported to date. In the study published in the journal BMC Genomics, Drs. Michael Farkas, Eric Pierce and colleagues in the Ocular Genomics Institute at Mass. Eye and Ear reported a complete catalog of the genes expressed in the retina. This is a valuable resource for the vision research community, and the data are available via the OGI website (see http://oculargenomics.meei.harvard.edu/index.php/ret-trans). - Reported that the adeno-associated virus AAV9 selectively targets cone photoreceptors in the non-human primate. - Milestones from the OGI include: Genomics core facility open, and providing research genomics services as well as CLIA-certified genetic diagonstic testing (information available via OGI website; see http://oculargenomics.meei.harvard.edu/index.php/gc and http://oculargenomics.meei.harvard.edu/index.php/gdt, respectively). - Recruited Dr. Xiaowu Gai to lead the Bioinformatics program of the OGI, and establish a Bioinformatics Shared Resource for the Department. Dr. Gai is a talented informaticist, and is currently Director of Biomedical Informatics, Loyola University Chicago Stritch School of Medicine. - The first OGI course "Genetics and genomics of ocular disease," directed by Dr. Janey Wiggs was presented as a satellite meeting of the American Society of Human Genetics. - Berman Gund Laboratory for the Study of Retinal Degenerations - Used whole-genome sequencing to identify pathogenic DNA structural changes and a new disease gene for retinitis pigmentosa. Cornea: - Completed a clinical study evaluating the efficacy of a topical combined anti-PDGF and anti-VEGF therapy in corneal angiogenesis. - Created and validated an ocular redness continuous (0.0 - 100.0) scale using a novel, state-of-the-art computer program. - Completed a study assessing the use of tear osmolarity as a new method to diagnose and monitor dry eye disease. - Developed telomerase-immortalized corneal endothelial cell line which will provide a new tool for the in vitro study of corneal endothelial cell biology and will be made available to the NIH community. - Determined that deficiency in Nrf2-regulated pathway is involved in the pathogenesis of Fuchs endothelial corneal dystrophy. - Determined that corneal limbal fibroblasts can be differentiated into corneal epithelial cells thus serving as a novel source of corneal epithelium usually destroyed in limbal stem cell deficiency disorders. - Demonstrated the presence of the integrin MadCAM-1 in the ocular surface vasculature and determined its role in the recruitment of corneal immune cells. - First human implantation of an intraocular device to measure IOP by telemetry. This may resolve the inability to measure IOP in keratoprosthesis patients. - Conducted the first large scale cataract surgery outcomes review (18,000 cases) in the UK independent sector (private-sector owned treatment centers contracted within the English National Health Service to treat NHS patients free at the point of use). - Demonstrated with live corneal imaging that unilateral corneal infections, including in herpes zoster ophthalmicus, lead to contralateral changes in corneal nerves in the unaffected eye, suggesting neuro-regulatory mechanisms between eyes. - Demonstrated that a drug-eluting contact lens can deliver a therapeutic amount of a glaucoma medication for one month. - Determined that devices used in PROSE treatment can be customized to accommodate any eye with keratoconus or post-LASIK ectasia regardless of disease severity. - Performed first collagen cross-linking in Boston, an experimental treatment for keratoconus, under the auspices of an FDA-sanctioned clinical trial. - Completed a study on worldwide incidence of infections after keratoprosthesis, and evaluation of optimal antibiotics prophylaxis. - Determined risk of light damage to retina during keratoprosthesis surgery. - Received FDA approval for the use of titanium in keratoprosthesis. - Quantified the risk of glaucoma after keratoprosthesis. - Constructed a new glaucoma valve. - Demonstrated radical reduction of complications by using oversized back plates in keratoprosthesis. - Published the largest ever series of pediatric herpes simplex. Demonstrated use of acyclovir in children and recommended treatment and maintenance doses (Liu et al, Ophthalmology 2012). - Demonstrated oversized backplates for KPro associated with better wound anatomy to try to reduce RPM formation (Cruzat et al, Cornea 2013) - MEEI will be a premier site for the upcoming Zoster Eye Disease Study (ZEDS), which will evaluate the effect of long-term systemic antiviral of the ophthalmic complications of shingles. Drs Colby and Langston will serve on the Executive Committee for this study. - Completed and have in press in Cornea clinical study showing that ganciclovir gel (Zirgan) is rapidly effective in healing Herpes zoster pseudodendritic ulcers of the cornea. - Completed clinical study "Patients with Infectious Keratitis Demonstrate Persistent and Long-term Increase in Immune cells and Diminished Subbasal Corneal Nerves After Cessation of Anti-Microbial Therapy -- A Laser in vivo Confocal Microscopy Study." - Demonstrated that a drug-eluting contact lens can deliver a therapeutic amount of a glaucoma medication for one month, published in Biomaterials. - Reported the findings from a large, multi-center study that found that excellent retention of the Type I Boston Kpro - 93% of the 300 Kpro implants were retained at their last follow-up, corresponding to a retention time of 396 patient-years or 1.42 years/keratoprosthesis in Ophthalmology. - Validated measurement of corneal dendritiform cells by in vivo confocal microscopy as a measure to assess ocular surface inflammation - Completed large multi-center clinical trial, demonstrating that combination of contact lenses and contact lens solutions are more important that each factor alone in inducing ocular surface inflammation - Launched grant from the Department of Defense to conduct a multi-center clinical trial to assess the safety and efficacy of an anti-VEGF in patients who are at high-risk for graft rejection following their corneal transplant. - Completed several clinical studies demonstrating that the use of autologous serum tears result in corneal nerve regeneration and in reversal of symptoms of corneal neuralgia and light sensitivity in patients with corneal neuropathies. - Completed a study evaluating the efficacy of a steroid vs. a steroid and antibiotic in patients with ocular inflammation related to dry eye disease - Reported on patients with bilateral corneal ulceration in ocular graft-versus-host disease. - Created novel software programs to quantify ocular surface staining and ocular redness, methodologies which will allow for more accurate measurements of ocular disease and progression. - Generated a large database on patients with ocular graft-versus-host disease. - Developed a surgical safety checklist for refractive procedures in association with the Institute for Safety in Office-based Surgery (ISOBS). - Published a novel method for cross linking ectatic corneas. | |
| Glaucoma: | - Contributed to an international effort reporting on 27 genetic loci that explain variance in central corneal thickness. Six of these loci are also associated with keratoconus and 1 represented a new locus for primary open-angle glaucoma. This work was published in Nature Genetics. - On behalf of the GLAUGEN (Glaucoma Genes and Environment) study and the NEIGHBOR (National Eye Institute Glaucoma Human Genetics Collaboration) consortium, glaucoma investigators used a case-only approach to demonstrate that genetic loci in the CDKN2B-AS1 region alter optic nerve vulnerability to glaucomatous damage. - Demonstrated an inverse relation between serum TNF receptor 2 levels and incident normal tension glaucoma among women. This study is based on a case control group nested within a population-based study (the Nurses Health Study) and serum samples on cases were collected prior to when glaucoma treatment was instituted. To the best of our knowledge, this is the first demonstration of a serum biomarker that is associated with a reduced risk of open-angle glaucoma. - Described the results of a randomized trial comparing the impact of fixed combination timolol-dorzolamide to fixed combination timolol-brimonidine in the co-regulation of retinal blood flow and ocular perfusion pressure. - Dr. Emmanuel Buys (MGH) and several members of the Harvard Glaucoma Center of Excellence, described a murine model of open angle glaucoma that is based on knocking out the intracellular receptor for nitric oxide, soluble guanylate cyclase. These mice develop modest, age-related increases in IOP and optic nerve degeneration that mimics the normal tension variant of primary open-angle glaucoma. More significantly, Dr. Buys and co-workers demonstrated that a common variant in the gene region for soluble guanylate cyclase is associated with primary open angle glaucoma that presents with paracentral visual loss. - Led an effort to demonstrate that several of the prostaglandin analogues in current use to treat glaucoma are strongly associated with atrophy of the periorbital fat, upper eyelid ptosis and loss of low eyelid steatoblepharon. - On behalf of the GLAUGEN (Glaucoma Genes and Environment) study and the NEIGHBOR (National Eye Institute Glaucoma Human Genetics Collaboration) consortium, investigators evaluated the collective relation between common genetic polymorphisms involved in estrogen metabolism and primary open-angle glaucoma. The work demonstrates that this panel of estrogen metabolizing polymorphisms is associated with primary open glaucoma in women but not in men. - Confirmed that TMCO1 loci are associated with intraocular pressure in conjunction with the GLAUGEN (Glaucoma Genes and Environment) study, the NEIGHBOR (National Eye Institute Glaucoma Human Genetics Collaboration) consortium, and the Age-related Macular Degeneration- Michigan, Mayo, AREDS and Pennsylvania study investigators. - Contributed to the International Consortium of African Ancestry Research in Glaucoma and demonstrated that genetic loci in the CDKN2B-AS1 region are associated with primary-open angle glaucoma among African Americans but not among African people derived from Ghana. | |
| OTOLARYNGOLOGY: | - Benjamin Bleier, M.D., Nicolas Busaba, M.D., Stacey Gray, M.D., and Eric Holbrook, M.D., have co-authored a study on the effectiveness of different treatments of nosebleeds for adults. The study, published in Otolaryngology-Head and Neck Surgery, found that in a limited observation, surgical and/or medical intervention offered the best outcome in adults with nosebleeds. - Albert Edge, Ph.D., is the lead author of a study conducted with hearing researchers at Massachusetts Eye and Ear Infirmary and Harvard Medical School who have, for the first time, regenerated sensory hair cells in the ear, resulting in restored hearing to noise-damaged ears. The Jan. 10, 2013 issue of Neuron features the research study, as well as a video discussion with Dr. Edge. - In a May 2013 issue of Cancer, investigators at Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary, including Edmund Mroz, Ph.D., Aaron Tward, M.D., Ph.D., and James Rocco, M.D., Ph.D., describe how their measure of heterogeneity of cells within a tumor appears to predict treatment outcomes of patients and was a better predictor of survival than most traditional risk factors in a small group of patients with squamous cell carcinoma, the most common type of head and neck cancer. - In a March issue of the Journal of Neuroscience, researchers found that noise exposure is clearly more dangerous than typically thought and gained insight into why it is difficult for some people to hear in "everyday" noisy environments. Stephane Maison, Ph.D. and M. Charles Liberman, Ph.D., were lead authors on this publication. - Led by Daniel Lee, M.D., researchers from the Wilson Auditory Brainstem Implant Program at Massachusetts Eye and Ear are currently conducting the only FDA-approved clinical trial in the U.S. for adult deaf patients who do not have NF2 to receive the ABI. The study was given clearance by the Human Studies Committees of Mass. Eye and Ear and Harvard Medical School in November 2012. A second study for pediatric patients who are deaf but do no have NF2 to receive the ABI was FDA-approved in May 2013. Radiology: - Renee Mitchell, Lead CT/XRAY radiologic technologist, performed high resolution cadaveric sinus scans for Dr. Benjamin Bleier for image guidance during the resident sinus dissection courses. - Renee Mitchell worked with Dr. Yoojin Chung and Jennifer O'Malley on a study with Dr. Bertrand Delgutte who is the principal investigator of these studies, where cochlear implanted rabbits are part of projects investigating neural responses to electrical stimulation and brain plasticity in animal models of human cochlear implants at the Eaton-Peabody Lab. The imaging scans are to ascertain the proper positioning of the CI's in these animals. | |
| FORM 990, PART III, LINE 4B: | EDUCATION | ACADEMIC PROGRAMS: OTOLARYNGOLOGY: - 18 RESIDENTS - 11 CLINICAL FELLOWS - 49 RESEARCH FELLOWS - 2 RESEARCH RESIDENTS OPHTHALMOLOGY: - 23 RESIDENTS - 26 CLINICAL FELLOWS - 102 RESEARCH FELLOWS Ophthalmology: - International Collaborations. The Department continues to build upon existing relationships that HMS Ophthalmology faculty and Chinese colleagues have been cultivating for several years. Faculty from Mass. Eye and Ear and Schepens traveled to China in a series of visits this year to exchange perspectives on research efforts and clinical care and management practices. One key mission of the trip was to strategically and cooperatively identify training opportunities as part of the Department's new International Research & Training program, which is now working smoothly to place trainees in department laboratories. Faculty from Eye and ENT Hospital of Fudan University visited in June for the Annual & Alumni Department meeting and a series of discussions. - Dong Feng Chen, MD, PhD Chair of Women's Eye Health.org is collaborating with associates from Peking University First Hospital to produce an educational TV series about eye disease for Beijing TV. The series complements the organization's worldwide outreach efforts to build awareness of the prevalence of eye disease in women. - The new Office of Global Surgery and Health established at Mass. Eye and Ear partners with training hospitals in underserved countries to improve residency programs in ophthalmology through onsite surgical instruction, remote education innovation and opportunities for research collaboration. - Inaugural HMS Ophthalmology Faculty Retreat. More than 100 Harvard Medical School (HMS) Department of Ophthalmology faculty members joined together for a two-day retreat at Wentworth by the Sea in Newcastle, NH on April 5-6, 2013. The inaugural event united clinicians and scientists from across the department and presented a forum for candid discussion, dialogue and exchange that aimed to coalesce translational efforts and more rapidly advance bench to bedside discovery. The retreat also provided a relaxed and casual "meet-and-greet" venue for faculty. Topics of discussion included overviews of the Department's growing Centers of Excellence and Institutes, expanded international collaborations, strengthened department-industry partnerships, and faculty development efforts. - Faculty Promotions and Appointments: HMS Appointments: - Endowed Professorships: - Patricia D'Amore, PhD, MBA, FARVO, The Charles L. Schepens Professor of Ophthalmology - Dean Eliott, MD, Stelios Evangelos Gragoudas Associate Professor of Ophthalmology - Professor of Ophthalmology: - Darlene Dartt, PhD, FARVO, Schepens/Mass. Eye and Ear - Associate Professor of Ophthalmology: - Don Bienfang, MD, Brigham and Women's Hospital - Assistant Professor of Ophthalmology: - Joseph Ciolino, MD, Mass. Eye and Ear - Suzanne Freitag, MD, Mass. Eye and Ear - Qin Liu, MD, PhD, Mass. Eye and Ear - Vincent Patalano, MD, Cambridge Health Alliance - Luk Vandenberghe, PhD, MSc, Mass. Eye and Ear - Michael Yoon, MD, Mass. Eye and Ear - Instructor in Ophthalmology: - Andrea Cruzat, MD, Schepens/Mass. Eye and Ear - Juan Ding, PhD, Schepens/Mass. Eye and Ear - Tobias Elze, PhD, Schepens/Mass. Eye and Ear - Ahmad Kheirkhah, MD, Schepens/Mass. Eye and Ear - Haijiang Lin, MD, PhD, Mass. Eye and Ear - Eleftherios Paschalis, PhD, MSc, Mass. Eye and Ear - Daniel Sun, PhD, OD, Mass. Eye and Ear - Xiaohong Zhou, MD, PhD, Mass. Eye and Ear - Cornea Center of Excellence hosts three days of unparalleled learning and discussion. The HMS Department of Ophthalmology Cornea Center of Excellence (COE) took center stage on October 17-19th when it hosted its first International Workshop at Mass. Eye and Ear followed by the 28th Biennial Cornea Conference held at the Schepens Starr Center for Scientific Communications. The inaugural International Workshop brought together a multidisciplinary group of more than 20 scholars. Both physicians and scientific researchers presented current research findings, exchanged scientific ideas, and strengthened international collaboration in the field of cornea and ocular surface research. The scientific program focused on virology, immune regulation, ocular surface, new imaging technologies, and regenerative medicine. Notably, Schepens alumnus and Professor and Chair of Ophthalmology at Kyoto Prefectural University of Medicine, Shigeru Kinoshita, MD, PhD, attended the workshop and also presented "Future Therapeutic Modalities for Devastating Ocular Surface and Corneal Disorders" during Grand Rounds earlier in the day. - The 4th Annual Mass. Eye and Ear Vitrectomy Course. The Course received unanimously positive feedback from this year's 48 fellows and six residents who attended from around the country. The free, two-day training intensive, held on July 19-20, 2013 attracted 33 world-class faculty members who joined together to deliver a brief, but comprehensive, introduction to the theory and practice of vitreoretinal surgery. Organized by Dean Eliott, MD, John Loewenstein, MD, and Demetrios Vavvas, MD, PhD, the course consisted of lectures, panel discussions, surgical simulation lab, and surgical wet lab in a setting with low student-to-teacher ratio. Emphasis on hands-on training and close interaction with faculty has made this course a tremendous success since its inauguration. All of the faculty have volunteered to return next year. since its inauguration. All of the faculty have volunteered to return next year. |
| OTOLARYNGOLOGY: | - Professor: - Christopher Shera, Ph.D. - Associate Professor: - Daniel Lee, M.D. - Assistant Professor: - Benjamin Bleier, M.D. - Robin Lindsay, M.D. - Stephane Maison, Ph.D. - Instructor (promoted from training status): - Mitchell Day, Ph.D. - Mingqian Huang, Ph.D. - Albena Kantardzhieva, Ph.D. - This year the department celebrated the class of 2013 at a June 21st ceremony held in the Meltzer auditorium. Our outstanding graduates included Drs. Sang Kim, Josh Meier, Daniel Roberts, and Josef Shargorodsky. We also welcomed five new residents to the program this year, Drs. Pete Creighton, Taha Jan, Brian Lin, Matthew Naunheim, and George Scangas. - The Department hosted the 12th International Facial Nerve Symposium over the weekend of June 28th, directed by Drs. Tessa Hadlock, Mack Cheney, and Michael McKenna. This four-day, lecture filled symposium included daily keynote addresses on topics ranging from facial nerve reconstruction to social functioning with facial paralysis. - A number of Mass. Eye and Ear physicians attended the International Federation of Otolaryngology Societies (IFOS) meetings in Seoul, Korea in May 2013, including Drs. Michael Rho, Eric Holbrook, Stacey Gray, Derrick Lin, James Rocco, Daniel Lee, Gregory Randolph, Nicolas Busaba, Phillip Song, Ramon Franco, and Head and Neck Surgical Oncology fellow Dr. Alice Lin. The group presented multiple lectures, panels, and courses to an international audience of otolaryngologists, with more than 4,500 attendees. The group plans to create an MEEI program for the next IFOS meeting in Paris in 2017. - Stacey Gray, M.D., was involved in a number of conferences in her field this year, serving as invited speaker and panel moderator for many of these engagements. This year she contributed to the Harvard Macy Institute Program for Educators in the Health Professions, the Combined Otolaryngology Spring Meeting in Orlando, the American Rhinology Society Summer Symposium in Chicago, the International Federation of Oto-Rhino-Laryngological Societies World Congress in Seoul, and the American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting. - Christopher Halpin, Ph.D., delivered the keynote address at the Spanish Congress of Audiology, Royal College of Physicians, Seville, titled "Clinical word recognition and audiologic disorders." Dr. Halpin also spoke at the Sociedad Espanola de Otorrhinolaryngology in Madrid, Spain in 2013. - Eric Holbrook, M.D., has been invited to speak and serve as a faculty member for the European Rhinology Society/ISIAN Congress in Amsterdam in 2014. - Richard Lewis, M.D., was an invited speaker on "Central vestibular processing investigated with electrical stimulation of canal ampullary nerves," at the Sensing Motion for Action Symposium in Montreal in July 2013. Dr. Lewis also spoke on "Investigating vestibular function with perceptual threshold testing," at Spaulding Hospital in Boston in April 2013. - Daniel Polley, Ph.D., lectured at the February 2013 meeting for the Association of Research in Otolaryngology on cortical modulation of sound representations in the auditory thalamus. - Gregory Randolph, M.D., served as panel moderator of "Avoidance of Complication in Thyroid/Parathyroid Surgery," and as panelist for "Papillary Carcinoma: prophylactic central neck dissection" at the American Cancer Society meetings. Dr. Randolph also served on the steering committee for the 2nd World Congress on Thyroid Cancer, held in Toronto from July 10th through the 14th in 2013. The Congress is a global multidisciplinary meeting of all specialists involved in the treatment of thyroid nodule disease and thyroid cancer. - Konstantina Stankovic, M.D., Ph.D., presented at the February 2013 Association for Research in Otolaryngology (ARO) meeting on a selection of her unpublished work, including, "Loss of FGF23 signaling results in mixed hearing loss and middle ear malformation," "Molecular network analysis of hearing loss and hypogonadism," "Examining the role of Gtf2ird1 deletion in auditory physiology and behavior in a murine model of Williams-Beuren Syndrome," and "Finding characteristic DFNA9 cochlin-staining eosinophilic deposits in the middle ear." Dr. Stankovic also presented at the American Otologic Society and American Neurotology Society meetings in April 2013 on the following topics, "Metabolomics analysis of pharmacotherapies for sensorineural hearing loss," "Aspirin intake correlates with halted growth of sporatic vestibular schwannoma in vivo," and "Molecular network analysis of sporadic vestibular schwannoma pathobiology highlights actin as a major modulator of tumor growth." Radiology: - The radiologists wrote or participated in 34 papers including:Borodic GE, Caruso PA, Acquadro M, Chick S. "Parry-Romberg Syndrome Vasculopathy and its Treatment with Botulinum Toxin". Ophthal Plast Reconstr Surg May 2013. - Gao Y, Moonis G, Cunnane ME, Eisenberg RL. "Lacrimal Gland Masses". Am J Roentgenol 2013 Sep; 201(3):W371-81. - Lesnik D, Cunnane ME, Zurakowski D, Acar GO, Ecevit C, Mace A, Kamani D, Randolph GW. "Papillary Thyroid Carcinoma Nodal Surgery Directed by a Preoperative Radiographic Map Utilizing CT Scan and Ultrasound in all Primary and Reoperative Patients". Head Neck 2013 Apr; 2:232-77. - Quesnel AM, Moonis G, Appel J, O'Malley JT, McKenna MJ, Curtin HD, Merchant SN. "Correlation of Computed Tomography with Histopathology in Otosclerosis". Otol Neurotol 2013 Jan; 34(1):22-8. - Juliano AF, Ginat D, Moonis G. "Imaging Review of the Temporal Bone-Part I: Anatomy and Inflammatory and Neoplastic Processes". Radiol 2013 Oct; 269(1):17-33. - Ginat D, Freitag SK, Kieff D, Grove A, Fay A, Cunnane ME, Moonis G. "Radiographic Patterns of Orbital Involvement in IgG4-Related Disease". Ophthal Plast Reconstr Surg 2013 Jul-Aug; 29(4):261-6. Ophthal Plast Reconstr Surg 2013 Jul-Aug; 29(4):261-6. | |
| FORM 990, PART III, LINE 4C: | CLINICAL CARE | Ophthalmology: - Mass. Eye and Ear, Longwood. Patient visits to the new Mass. Eye and Ear, Longwood multi-specialty ambulatory care center at 800 Huntington Avenue have climbed steadily since the facility opened its doors to patients in December, 2012. During 10 months in FY13, the Longwood medical team and staff handled nearly nine thousand patient visits. Four additional clinicians joined the practice this fall to keep pace with growth, bringing the number of Longwood practitioners to 13. Clinicians handle a full range of comprehensive and subspecialty services and the facility is fully equipped for surgery, procedures, imaging and diagnostics. The recent expansion to the Longwood Medical Area (LMA) has broadened and enhanced collaborations with LMA HMS Ophthalmology affiliates, neighborhood institutions and the community in general. Joslin Diabetes Center has co-located clinical offices there and Joslin physicians are now providing a full array of high quality, comprehensive and subspecialty eye care to ophthalmology patients who are at-risk for diabetes-related eye complications. Additionally, Mass. Eye and Ear, Longwood's closer proximity to Brigham and Women's (BWH) Hospital is speeding up communication with BWH physicians and the referral community, and providing faster access to care for patients. Led by Mass. Eye and Ear, Longwood Clinical Director, Carolyn Kloek, MD, several open houses were held before and after the Longwood facility opening to introduce the facility and staff to the neighboring hospital and referring physician community. Mass. Eye and Ear, Longwood is now well integrated into the community and is ready resource for nearby medical practices whose clinicians are operating in the facility's new surgical suite and utilizing its ophthalmic imaging and testing resources. - Mass. Eye and Ear and MGH Streamline Care for Patients with Diabetic Eye Disease. Mass. Eye and Ear and Mass General Hospital have collaborated to implement a new, streamlined patient care process for MGH patients who require an OPTOS diabetic eye screening or a diabetic eye exam. A Mass General PCP or nurse practitioner initiates testing by filling out a Mass. Eye and Ear order form and directs patients to Mass. Eye and Ear's Fluorescein Department. MGH patients are given the next available photographer for processing. Images are uploaded to the Mass. Eye and Ear image viewing system and a clinical message is posted in the LMR to alert the MDs reading the test. Once they review and document the result, a clinical message is sent to the referring PCP at Mass. General. Results are provided within one week and - in the event of an abnormal result - Mass. Eye and Ear staff will contact the patient to coordinate an appointment. Patients with normal studies are notified by mail or via Patient Gateway. - Mass. Eye and Ear Expands Optometry Team. Mass. Eye and Ear continues to grow its cadre of optometrists in a strategic move to extend its patient base, partner with MDs to optimize patient scheduling and streamline care to patients. The Optometry service now includes six, full-time members. The two most recent recruits to the service - Mark Bernardo, OD, and Yan Jiang, OD, PhD - have established full-time practices at Mass. Eye and Ear, Longwood. - Mass. Eye and Ear Ranked a Top Specialty Hospital. Since 1990, Mass. Eye and Ear has been one of the top ranked hospitals in the nation for ophthalmology, according to U.S. News & World Report magazine's "America's Best Hospitals" 2013 survey. This year, Mass. Eye and Ear, Massachusetts General Hospital ranked #4 in Ophthalmology. - Mass. Eye and Ear to Release the 4th Annual Quality and Outcomes Report. Mass. Eye and Ear prepared its 4th Annual Quality and Outcomes Report, documenting clinical and surgical outcomes data for key Ophthalmology procedures. The 2013 Quality and Outcomes Report (the third combined Ophthalmology/ENT report) will provide a full view of our highly specialized care and surgery, while cataloguing measures that continue to establish industry benchmarks nationwide. - New Equipment and Technology: - Retina Service: The next-generation Canon Adaptive Optics Scanning Laser Ophthalmoscope (not yet in clinical use) has the potential to resolve individual cone cells in the retina, enabling clinicians to monitor progression of diseases of the retina to a degree never before possible. - Retina/Glaucoma Service: TopCon Swept Source OCT allows the detection and resolution of individual retinal layers and is particularly helpful in retinal diseases such as wet AMD. This new technology has the potential to distinguish single photoreceptors in the retina with the potential for better resolution of sub-RPE images. |
| COMMUNITY SERVICE: | LOCAL/REGIONAL: | - Support Groups - Mass. Eye and Ear Eye Plastics hosted a quarterly Thyroid Eye Disease support group, which is led by Suzanne Freitag, MD. This support group is run in collaboration with the Graves Disease and Thyroid Foundation along with MGH endocrinology and Dr. Greg Randolph of Mass. Eye and Ear ENT. - Mass. Eye and Ear Vision Rehabilitation Support Group runs weekly for 8 weeks in the Vision Rehabilitation Clinic, and is led by a Mass. Eye and Ear social worker and a social worker who has low vision. - Community Forums, Lectures and Special Events - Ula Jurkunas, MD, and Michael Young, PhD, presented a seminar entitled, "The Stem Cell Stories: Revolutionary Results from Boston-area Researchers," at a free public forum sponsored by the Harvard Stem Cell Institute as part of the International Society for Stem Cell Research's 11th Annual Meeting. The seminar was held at the OMNI Parker House in Boston on June 11, 2013. - On June 22, 2013 Lucy Shen, MD gave a talk to the New England Chapter of the Glaucoma Foundation on the importance and meaning of glaucoma tests. - Screenings - In conjunction with Vision Coalition, Mass. Eye and Ear provided dilated eye exams and eyeglasses for students from the Year Up program in July at both the main campus and at Longwood. Mark Bernardo, OD, Angela DuBois, Myrna Duran, Nolette Ferjuste, Alexander Lascko, Do Lee and Amy Watts, OD participated in this important program. - Community Benefits vision screenings for students at Camp Harbor View (18th Year) were held July 23 and August 9, 2013. Staff from Mass. Eye and Ear and Children's Hospital Ophthalmology Foundation screened 235 children in total, with 78 requiring follow-up care. - A team from Mass. Eye and Ear and Children's Hospital Ophthalmology Foundation visited the Neighborhood House Charter School on October 11, 2013 and provided more than 320 screenings. Mass. Eye and Ear has provided vision and hearing screenings to the children at this Boston school as part of its community benefits program since the school opened in 1995. Dr. Ankoor Shah and Chief Ophthalmic Tech, Shakhsanam Aliyeva led the team of residents, technicians and staff who helped with the event. |
| OTOLARYNGOLOGY: | - New Equipment and Technology: - An exciting milestone in our educational efforts, construction on our new state-of-the-art otolaryngology surgical training laboratory was completed early this year. The Joseph B. Nadol, Jr., M.D., Otolaryngology Surgical Training Laboratory allows for advanced instruction capabilities in nearly every subspecialty of otolaryngology and will serve as a resource for our residents and fellows, as well as experienced surgeons in continuing medical education. - Derrick Lin, M.D., and James Rocco, M.D., Ph.D., have pioneered efforts toward bringing transoral robotic surgery to appropriate head and neck cancer patients at Mass. Eye and Ear. Drs. Lin and Rocco now offer this treatment using facilities at Winchester Hospital, which is located in the northwest suburb of Boston. Radiology: - New Equipment and Technology: - A trial of a 3D Accuitomo CT system continued through FY13 and will continue in FY14. This is a no cost trial in an effort to work with the manufacturer to improve temporal bone scans and image resolution. Referring MD's have responded positively on the increased quality of images for these non-contrast studies. An evaluation to lease or purchase the system will be performed in FY14. - We are in the final evaluation stage to select a new CT system vendor (GE or Siemens) in an effort to replace the existing Siemens Somatom 40-slice CT system. The current system is nearing end of life and is approaching eight years old. The new CT system will be implemented in FY14. | |
| FORM 990, PART VI, LINE 1A: | THE INFIRMARY'S BYLAWS STATE THE FOLLOWING: | THERE SHALL BE AN EXECUTIVE COMMITTEE CONSISTING OF THOSE INDIVIDUALS WHO ARE SERVING AS MEMBERS OF THE EXECUTIVE COMMITTEE OF THE MEMBER. THE EXECUTIVE COMMITTEE SHALL HAVE THE POWER TO TRANSACT ALL EMERGENCY BUSINESS OF THE CORPORATION DURING THE PERIOD BETWEEN THE MEETINGS OF THE BOARD OF DIRECTORS. THE EXECUTIVE COMMITTEE SHALL ALSO TRANSACT SUCH BUSINESS, PERFORM SUCH DUTIES, AND EXERCISE SUCH POWERS AS MAY BE DIRECTED OR DELEGATED BY THE BOARD OF DIRECTORS FROM TIME TO TIME. THE EXECUTIVE COMMITTEE SHALL KEEP A RECORD OF ITS PROCEEDINGS. ALL ACTIONS OF THE EXECUTIVE COMMITTEE SHALL BE REPORTED TO THE BOARD OF DIRECTORS AT ITS NEXT REGULAR MEETING. FORM 990, PART VI, LINE 7A: THE GOVERNOR OF THE COMMONWEALTH HAS THE AUTHORITY TO APPOINT TWO DIRECTORS. THE BYLAWS OF THE INFIRMARY STATE THAT THE REMAINING DIRECTORS ARE THOSE INDIVIDUALS SERVING AS DIRECTORS OF ITS SOLE MEMBER, THE FOUNDATION OF THE MASSACHUSETTS EYE AND EAR INFIRMARY, INC. ("THE FOUNDATION"). |
| FORM 990, PART VI, LINE 7B: | THE FOUNDATION IS THE SOLE MEMBER OF THE INFIRMARY AND RETAINS THE AUTHORITY TO MAKE DECISIONS REGARDING THE INFIRMARY. | |
| FORM 990, PART VI, LINE 11B: | THE INFIRMARY'S FORM 990 IS PREPARED BY PRICEWATERHOUSECOOPERS, LLP USING INFORMATION PREPARED BY MANAGEMENT. AFTER THE FORM 990 IS COMPLETED, IT IS REVIEWED BY THE DIRECTOR OF FINANCE OPERATIONS. THE FORM 990 IS THEN PRESENTED TO THE FINANCE COMMITTEE FOR REVIEW AND APPROVAL AS AUTHORIZED BY THE BOARD OF DIRECTORS. THE BOARD OF DIRECTORS ARE ALSO GIVEN THE FORM 990 FOR REVIEW WITH TIME TO SUBMIT COMMENTS AND QUESTIONS BEFORE FINAL FILING. | |
| FORM 990, PART VI, LINE 12C: | MEMBERS OF THE STAFF ARE REQUIRED TO DISCLOSE CONFLICTS OF INTEREST TO THEIR CHIEF OF SERVICE OR DEPARTMENT AND DIRECTOR OF LABORATORY/UNIT. MEMBERS OF THE BOARD OF DIRECTORS ARE REQUIRED TO DISCLOSE ANNUALLLY, IN WRITING, ANY INTERESTS THAT COULD GIVE RISE TO CONFLICTS. THE OFFICE OF THE INTERNAL LEGAL COUNSEL OBTAINS AND REVIEWS THE ANNUAL CONFLICTS OF INTEREST STATEMENTS SUBMITTED BY MEMBERS OF THE BOARD OF DIRECTORS, AND REPORTS ON THE SAME TO THE AUDIT AND COMPLIANCE COMMITTEE OF THE BOARD. WITH RESPECT TO INTERESTS DISCLOSED BY BOARD MEMBERS THAT COULD GIVE RISE TO CONFLICTS OF INTEREST, THE INTERNAL LEGAL COUNSEL REVIEWS ALL TRANSACTIONS BETWEEN SUCH INTERESTS AND AFFILIATES OF THE INFIRMARY, TO DETERMINE WHETHER THESE TRANSACTIONS WERE CONDUCTED AT ARM'S LENGTH. | |
| FORM 990, PART VI, LINE 15: | THE CHAIRMAN OF THE COMPENSATION COMMITTEE OF THE BOARD OF THE INFIRMARY PRESENTS A RECOMMENDATION TO THE COMPENSATION COMMITTEE WHO HAVE FINAL APPROVAL OF THE CEO'S BASE SALARY AND BONUS AMOUNT. THE CEO RECOMMENDS EXECUTIVE SALARIES TO THE COMPENSATION COMMITTEE OF THE BOARD WHO HAS FINAL AUTHORIZATION TO APPROVE IT. TOTAL COMPENSATION FOR THE CEO, CHIEFS AND VICE PRESIDENTS, INCLUDING BONUS PAYMENTS, INCLUDING COMPARABILITY DATA, IS ANALYZED BY INDEPENDENT COMPENSATION CONSULTANTS AND IS DETERMINED TO BE REASONABLE. | |
| FORM 990, PART VI, LINE 19: | SUMMARIZED FINANCIAL STATEMENTS ARE AVAILABLE ON THE INFIRMARY'S WEBSITE: WWW.MASSEYEANDEAR.ORG. AUDITED FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. THE INFIRMARY'S GOVERNING DOCUMENTS AND FORM 990 ARE AVAILABLE UPON REQUEST. THE CONFLICT OF INTEREST POLICY IS ALSO AVAILABLE UPON REQUEST. FORM 990, PART XI, LINE 9: PERIODIC PENSION COST $11,881,769 |
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