TY 2013 Form 990

(A) Name and Title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)	(E) Reportable compensation from related organizations (W- 2/1099-MISC)
(1) James A Baker III Esq........................................................................ Trustee	2.0 .......................	X		40,000	0
(2) Charlene Barshefsky Esq........................................................................ Trustee	2.0 .......................	X		40,000	0
(3) Susan Desmond-Hellmann MD MPH........................................................................ Trustee	2.0 .......................	X		0	0
(4) Joseph L Goldstein MD........................................................................ Trustee	2.0 .......................	X		53,500	0
(5) Garnett L Keith........................................................................ Trustee, Chairman Finance Comm	4.0 .......................	X		50,000	0
(6) Fred R Lummis........................................................................ Trustee	2.0 .......................	X		40,000	0
(7) Paul M Nurse PhD........................................................................ Trustee	2.0 .......................	X		40,000	0
(8) Alison M Richard PhD........................................................................ Trustee, Chairman Ed&Intl Comm	2.0 .......................	X		50,000	0
(9) Clayton S Rose PhD........................................................................ Trustee, Chairman Audit & Comp	6.0 .......................	X		50,000	0
(10) Kurt L Schmoke Esq........................................................................ Trustee, Chairman	6.0 .......................	X		60,000	0
(11) Anne M Tatlock........................................................................ Trustee	2.0 .......................	X		40,000	0
(12) Robert Tjian PhD........................................................................ President	40.0 .......................		X	1,299,797	51,324
(13) Cheryl A Moore........................................................................ Executive VP & COO	40.0 .......................		X	843,175	48,146
(14) Sean B Carroll PhD........................................................................ VP for Science Education	40.0 .......................		X	650,660	45,781
(15) Heidi E Henning Esq........................................................................ VP,General Counsel/Sec	40.0 .......................		X	503,753	47,064
(16) Mohamoud Jibrell........................................................................ VP for Information Technology	40.0 .......................		X	300,744	50,318
(17) Nitin V Kotak........................................................................ VP, CFO & Treasurer	40.0 .......................		X	401,043	46,671

(A) Name and Title	(B) Average hours per week (list any hours for related organizations below dotted line)	(E) Reportable compensation from related organizations (W- 2/1099-MISC)	(F) Estimated amount of other compensation from the organization and related organizations
(18) Erin K O'Shea PhD........................................................................ VP & Chief Sci Off	40.0 .......................	X				591,858	45,294
(19) Gerald M Rubin PhD........................................................................ VP&Exec Dir,Janelia Res Campus	40.0 .......................	X				704,229	115,823
(20) Kathy Wyszynski........................................................................ VP, Human Resources	40.0 .......................	X				274,576	34,511
(21) Landis Zimmerman........................................................................ VP & Chief Investment Officer	40.0 .......................	X				2,843,016	48,739
(22) Lauren T Spiliotes Esq........................................................................ Dep GenCounsel/Asst Sec	40.0 .......................	X				343,911	48,392
(23) Susan S Plotnick........................................................................ Assistant Treasurer & Director	40.0 .......................	X				233,719	44,389
(24) Monique L Marcus........................................................................ Assistant Controller	40.0 .......................	X				181,323	37,542
(25) Richard A Pender........................................................................ Man Dir - US Equities	40.0 .......................		X			1,317,203	46,612
(26) Robert J Kolyer Jr........................................................................ Man Dir - Diversified Assets	40.0 .......................		X			1,265,157	47,191
(27) Mark A Barnard........................................................................ Man Dir - Private Equities	40.0 .......................		X			1,025,127	47,875
(28) Stephen M Kitsoulis........................................................................ Man Dir - Fixed Income	40.0 .......................		X			896,868	46,986
(29) Anil Madhok........................................................................ Man Dir - Investments & COO	40.0 .......................			X		989,038	45,334
(30) Matthew R Lee........................................................................ Man Dir-Inv. Strtgy thru 8/13	40.0 .......................			X		836,182	32,887
(31) Michael B Shaffer........................................................................ Dir/Senior Trader thru 12/13	40.0 .......................			X		597,419	42,729
(32) William R Bishai MD PhD........................................................................ Lab Head	40.0 .......................			X		581,142	45,736
(33) Eric R Kandel MD........................................................................ Senior Investigator	40.0 .......................			X		570,133	53,561
(34) Craig A Alexander Esq........................................................................ VP,Gen Counsel&Sec thru 4/13	40.0 .......................				X	552,381	22,287
(35) Thomas R Cech PhD........................................................................ Investigator	40.0 .......................				X	601,546	48,329
(36) Jack E Dixon PhD........................................................................ VP/Chief Sci Off thru 6/13	40.0 .......................				X	466,017	39,813

(A) Name and business address	(B) Description of services	(C) Compensation
Aramark Harrison Lodging, 1101 Market StPHILADELPHIAPA19107	Conference Ctr Mgt	3,922,354
Southeastern Asset Management, 6410 Poplar Avenue Suite 900MEMPHISTN38119	Investment Mgt	3,441,819
Walter Scott Partners Ltd, ONE CHARLOTTE SQUAREEDINBURGHMIDLOTHIANUKEH2 4DZ	Investment Mgt	3,242,113
Iridian Asset Management LLC, 276 Post Road WestWESTPORTCT06880	INVESTMENT MGT	3,083,823
Bank of NY Mellon, PO Box 392006PITTSBURGHPA15251	CUSTODIAL/INVESTMENT	2,552,532
2 Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization 157

Do not include amounts reported on lines 6b, 7b, 8b, 9b, and 10b of Part VIII.	(A) Total expenses	(B) Program service expenses	(C) Management and general expenses	(D) Fundraising expenses
1	Grants and other assistance to governments and organizations in the United States. See Part IV, line 21	95,687,261	95,687,261
2	Grants and other assistance to individuals in the United States. See Part IV, line 22	8,881,298	8,881,298
3	Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16	7,033,104	7,033,104
4	Benefits paid to or for members	0
5	Compensation of current officers, directors, trustees, and key employees ....	15,152,144	2,270,812	12,881,332
6	Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) ....	705,632	641,823
7	Other salaries and wages	276,579,056	249,164,387	27,466,969
8	Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) ....	24,187,175	21,857,992	2,334,413
9	Other employee benefits .......	131,941,663	117,478,870	14,469,072
10	Payroll taxes ...........	17,911,217	15,949,610	1,961,607
11	Fees for services (non-employees):
a	Management ......	0
b	Legal .........	3,593,840	2,688,621	905,219
c	Accounting ...........	818,550		818,550
d	Lobbying ...........	0
e	Professional fundraising services. See Part IV, line 17	0
f	Investment management fees ......	86,192,431		86,192,431
g	Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) ........	34,645,908	25,130,034	9,515,874
12	Advertising and promotion ....	0
13	Office expenses .......	5,821,435	4,572,680	1,248,755
14	Information technology ......	5,933,535	582,916	5,350,619
15	Royalties ..	8,937		8,937
16	Occupancy ...........	106,311,423	103,527,878	2,783,545
17	Travel ............	8,252,706	6,804,864	1,447,842
18	Payments of travel or entertainment expenses for any federal, state, or local public officials ......	0
19	Conferences, conventions, and meetings ....	3,363,836	2,883,952	479,884
20	Interest ...........	62,526,266	1,024,589	61,501,677
21	Payments to affiliates .......	0
22	Depreciation, depletion, and amortization .....	95,998,998	85,794,447	10,204,551
23	Insurance ..............	443,168	134,047	309,121	0
24	Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a	LAB & OTHER SCIENTIFIC SUPPLIE	133,362,200	132,662,823	699,377
b	MINOR EQUIPMENT & RENOVATIONS	16,570,957	16,570,957
c	EQUIPMENT MAINTENANCE	14,808,945	12,365,856	2,443,089
d	INCOME TAX	1,100,300		1,100,300
e	All other expenses	5,233,959	5,090,504	143,455
25	Total functional expenses. Add lines 1 through 24e	1,163,065,944	918,799,325	244,266,619	0
26	Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here if following SOP 98-2 (ASC 958-720).

Part X Balance Sheet Check if Schedule O contains a response or note to any line in this Part X ..............
	1	Cash–non-interest-bearing .............	0	1	0
2	Savings and temporary cash investments .........	374,609,412	2	305,401,048
3	Pledges and grants receivable, net ...........	0	3	0
4	Accounts receivable, net .............	0	4	0
5	Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of Schedule L ..................
		0	5	0
6	Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
		0	6	0
7	Notes and loans receivable, net .............	0	7	0
8	Inventories for sale or use ..............	0	8	0
9	Prepaid expenses and deferred charges ..........	7,388,741	9	8,948,454
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	1,848,686,635
b	Less: accumulated depreciation .....	10b	1,052,706,954	814,431,783	10c	795,979,681
11	Investments—publicly traded securities ..........	7,407,499,312	11	8,046,600,998
12	Investments—other securities. See Part IV, line 11 .....	10,892,032,785	12	12,571,418,897
13	Investments—program-related. See Part IV, line 11 .....	0	13	0
14	Intangible assets ...............	0	14	0
15	Other assets. See Part IV, line 11 ...........	181,759,494	15	131,980,563
16	Total assets. Add lines 1 through 15 (must equal line 34)......	19,677,721,527	16	21,860,329,641
	17	Accounts payable and accrued expenses .........	387,750,043	17	469,629,746
18	Grants payable .................	106,249,684	18	148,458,340
19	Deferred revenue ................	0	19	0
20	Tax-exempt bond liabilities .............	716,130,000	20	716,130,000
21	Escrow or custodial account liability. Complete Part IV of Schedule D..	0	21	0
22	Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
	persons. Complete Part II of Schedule L..........	0	22	0
23	Secured mortgages and notes payable to unrelated third parties ..	0	23	0
24	Unsecured notes and loans payable to unrelated third parties ....	1,237,912,529	24	1,238,158,876
25	Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D....................	328,672,794	25	694,346,013
26	Total liabilities. Add lines 17 through 25.........	2,776,715,050	26	3,266,722,975
		Organizations that follow SFAS 117 (ASC 958), check here and complete lines 27 through 29, and lines 33 and 34.
27	Unrestricted net assets ..............	16,901,006,477	27	18,593,606,666
28	Temporarily restricted net assets ...........	0	28	0
29	Permanently restricted net assets ...........	0	29	0
	Organizations that do not follow SFAS 117 (ASC 958), check here and complete lines 30 through 34.
30	Capital stock or trust principal, or current funds ........		30
31	Paid-in or capital surplus, or land, building or equipment fund .....		31
32	Retained earnings, endowment, accumulated income, or other funds		32
33	Total net assets or fund balances ...........	16,901,006,477	33	18,593,606,666
34	Total liabilities and net assets/fund balances ........	19,677,721,527	34	21,860,329,641

- TIN:

SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service

Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.

Attach to Form 990 or Form 990-EZ. right arrow

See separate instructions.
right arrow

Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

Reason for Public Charity Status (All organizations must complete this part.) See instructions.

The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)

A church, convention of churches, or association of churches described in section 170(b)(1)(A)(i).

A school described in section 170(b)(1)(A)(ii). (Attach Schedule E.)

A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name, city, and state:

Brigham&Womens Hospital,

Boston, MA

An organization operated for the benefit of a college or university owned or operated by a governmental unit described in

section 170(b)(1)(A)(iv). (Complete Part II.)

A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in section 170(b)(1)(A)(vi). (Complete Part II.)

A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)

An organization that normally receives: (1) more than 331/3% of its support from contributions, membership fees, and gross

receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of

its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses

acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)

An organization organized and operated exclusively to test for public safety. See section 509(a)(4).

An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box that describes the type of supporting organization and complete lines 11e through 11h.

Type I

Type II

Type III - Functionally integrated

Type III - Non-functionally integrated

By checking this box, I certify that the organization is not controlled directly or indirectly by one or more disqualified persons other than foundation managers and other than one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2).

If the organization received a written determination from the IRS that it is a Type I, Type II, or Type III supporting organization, check this box ..................................................

Since August 17, 2006, has the organization accepted any gift or contribution from any of the
following persons?

(i) A person who directly or indirectly controls, either alone or together with persons described in (ii)

Yes

and (iii) below, the governing body of the supported organization? ................

11g(i)

(ii) A family member of a person described in (i) above? ......................

11g(ii)

(iii) A 35% controlled entity of a person described in (i) or (ii) above? ................

11g(iii)

Provide the following information about the supported organization(s).

(i) Name of supported organization	(ii) EIN	(iv) Is the organization in col. (i) listed in your governing document?		(v) Did you notify the organization in col. (i) of your support?		(vi) Is the organization in col. (i) organized in the U.S.?		(vii) Amount of monetary support
(i) Name of supported organization	(ii) EIN	Yes	No	Yes	No	Yes	No	(vii) Amount of monetary support


Total

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990EZ.

Cat. No. 11285F

Schedule A (Form 990 or 990-EZ) 2013

Page 2

Part II

Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2009	(b) 2010	(c) 2011	(d) 2012	(e) 2013	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....
2	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......
3	The value of services or facilities furnished by a governmental unit to the organization without charge..
4	Total. Add lines 1 through 3
5	The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..
6	Public support. Subtract line 5 from line 4.

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2009	(b) 2010	(c) 2011	(d) 2012	(e) 2013	(f) Total
7	Amounts from line 4..
8	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...
9	Net income from unrelated business activities, whether or not the business is regularly carried on..
10	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)..
11	Total support (Add lines 7 through 10).

Gross receipts from related activities, etc. (see instructions) ..................

First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization, check this box and stop here................................................. right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2013 (line 6, column (f) divided by line 11, column (f)) .........

Public support percentage for 2012 Schedule A, Part II, line 14 ...............

16a

33 1/3% support test—2013. If the organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box
and stop here. The organization qualifies as a publicly supported organization ....................... right arrow

33 1/3% support test—2012. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow

17a

10%-facts-and-circumstances test—2013. If the organization did not check a box on line 13, 16a, or 16b, and line 14
is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain
in Part IV how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported
organization ..................................................... right arrow

10%-facts-and-circumstances test—2012. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line
15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here.
Explain in Part IV how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly
supported organization ................................................ right arrow

Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow

Schedule A (Form 990 or 990-EZ) 2013

Page 3

Part III

Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2009	(b) 2010	(c) 2011	(d) 2012	(e) 2013	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .
2	Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......
3	Gross receipts from activities that are not an unrelated trade or business under section 513..
4	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5	The value of services or facilities furnished by a governmental unit to the organization without charge..
6	Total. Add lines 1 through 5.
7a	Amounts included on lines 1, 2, and 3 received from disqualified persons...
b	Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.
c	Add lines 7a and 7b..
8	Public support (Subtract line 7c from line 6.)

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2009	(b) 2010	(c) 2011	(d) 2012	(e) 2013	(f) Total
9	Amounts from line 6...
10a	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
b	Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.
c	Add lines 10a and 10b.
11	Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.
12	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) ..
13	Total support. (Add lines 9, 10c, 11, and 12.)..

First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization,
check this box and stop here............................................. right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2013 (line 8, column (f) divided by line 13, column (f)) .........

Public support percentage from 2012 Schedule A, Part III, line 15 ...............

Section D. Computation of Investment Income Percentage

Investment income percentage for 2013 (line 10c, column (f) divided by line 13, column (f)) ......

Investment income percentage from 2012 Schedule A, Part III, line 17 .............

19a

33 1/3% support tests—2013. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ........ right arrow

33 1/3% support tests—2012. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ..... right arrow

Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions ..... right arrow

Schedule A (Form 990 or 990-EZ) 2013

Page 4

Part IV

Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; and Part III, line 12. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Explanation

Schedule A (Form 990 or 990-EZ) 2013

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service

Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet

Complete if the organization is described below. SchCMd Bullet

Attach to Form 990 or Form 990-EZ.
SchCMd Bullet

See separate instructions. SchCMd Bullet

Information about Schedule C (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

If the organization answered "Yes" to Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet

Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet

Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet

Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" to Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet

Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet

Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" to Form 990, Part IV, Line 5 (Proxy Tax) or Form 990-EZ, Part V, line 35c (Proxy Tax), then
Round Bullet

Section 501(c)(4), (5), or (6) organizations: Complete Part III.

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I-A

Complete if the organization is exempt under section 501(c) or is a section 527 organization.

Provide a description of the organization’s direct and indirect political campaign activities in Part IV.

Political expenditures .................................... SchCMd Bullet

Volunteer hours ........................................

Part I-B

Complete if the organization is exempt under section 501(c)(3).

Enter the amount of any excise tax incurred by the organization under section 4955 ......... SchCMd Bullet

Enter the amount of any excise tax incurred by organization managers under section 4955 ...... SchCMd Bullet

If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ..............

Yes No

Was a correction made? .........................................

Yes No

If "Yes," describe in Part IV.

Part I-C

Complete if the organization is exempt under section 501(c), except section 501(c)(3).

Enter the amount directly expended by the filing organization for section 527 exempt function activities SchCMd Bullet

Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ................................... SchCMd Bullet

Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b.. SchCMd Bullet

Did the filing organization file Form 1120-POL for this year? ..........................

Yes No

Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.

(a) Name	(b) Address	(c) EIN	(d) Amount paid from filing organization's funds. If none, enter -0-.	(e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.

For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.

Cat. No. 50084S

Schedule C (Form 990 or 990-EZ) 2013

Page 2

Part II-A

Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).

A Check SchCMd Bullet

if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN, expenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet

if the filing organization checked box A and "limited control" provisions apply.

Limits on Lobbying Expenditures (The term "expenditures" means amounts paid or incurred.)		(b) Affiliated group totals
1a	Total lobbying expenditures to influence public opinion (grass roots lobbying) ......
b	Total lobbying expenditures to influence a legislative body (direct lobbying) .......
c	Total lobbying expenditures (add lines 1a and 1b) ...................
d	Other exempt purpose expenditures ........................
e	Total exempt purpose expenditures (add lines 1c and 1d) ...............
f	Lobbying nontaxable amount. Enter the amount from the following table in both columns.
	If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
	Not over $500,00020% of the amount on line 1e.
	Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
	Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
	Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
	Over $17,000,000$1,000,000.

g	Grassroots nontaxable amount (enter 25% of line 1f) .................
h	Subtract line 1g from line 1a. If zero or less, enter -0-. ................
i	Subtract line 1f from line 1c. If zero or less, enter -0-. ................
j	If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting section 4911 tax for this year? ......................................	Yes No

4-Year Averaging Period Under Section 501(h) (Some organizations that made a section 501(h) election do not have to complete all of the five columns below. See the instructions for lines 2a through 2f on page 4.)
Lobbying Expenditures During 4-Year Averaging Period
	Calendar year (or fiscal year beginning in)	(a) 2010	(b) 2011	(c) 2012	(d) 2013	(e) Total

2a	Lobbying nontaxable amount

b	Lobbying ceiling amount (150% of line 2a, column(e))

c	Total lobbying expenditures

d	Grassroots nontaxable amount

e	Grassroots ceiling amount (150% of line 2d, column (e))

f	Grassroots lobbying expenditures

Schedule C (Form 990 or 990-EZ) 2013

Page 3

Part II-B

Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).

For each "Yes" response to lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.

(a)

Yes

(b)

Amount

During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:

Volunteers? .........................................

Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ....

Media advertisements? ....................................

Mailings to members, legislators, or the public? .........................

Publications, or published or broadcast statements? .......................

Grants to other organizations for lobbying purposes? .......................

Direct contact with legislators, their staffs, government officials, or a legislative body? ........

Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ......

Other activities? ..........................

Yes

1,597

Total. Add lines 1c through 1i ...............................

1,597

Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....

If "Yes," enter the amount of any tax incurred under section 4912 .................

If "Yes," enter the amount of any tax incurred by organization managers under section 4912 .....

If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? .......

Part III-A

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).

Yes

Were substantially all (90% or more) dues received nondeductible by members? ................

Did the organization make only in-house lobbying expenditures of $2,000 or less? ................

Did the organization agree to carry over lobbying and political expenditures from the prior year? ..........

Part III-B

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."

Dues, assessments and similar amounts from members .....................

Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).

Current year .........................................

Carryover from last year ....................................

Total ............................................

Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .

If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ................................

Taxable amount of lobbying and political expenditures (see instructions) ..............

Part IV

Supplemental Information

Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, line 2; and Part ll-B, line 1. Also, complete this part for any additional information.

Return Reference	Explanation
Schedule C, Part II-B, line 1i (Other Activities)	During the fiscal year, HHMI was a member of a number of non-profit organizations that engaged in lobbying activities on behalf of their memberships. HHMI is reporting as lobbying expenditures a portion of the membership dues that HHMI paid to these organizations.

Schedule C (Form 990 or 990EZ) 2013

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE D
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Financial Statements

Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b
SchDMd Bullet

Attach to Form 990. SchDMd Bullet

See separate instructions. SchDMd Bullet

Information about Schedule D (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.

		(a) Donor advised funds	(b) Funds and other accounts
1	Total number at end of year .........
2	Aggregate contributions to (during year) ...
3	Aggregate grants from (during year) .....
4	Aggregate value at end of year ........

Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............

Yes No

Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................

Yes No

Part II

Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.

Purpose(s) of conservation easements held by the organization (check all that apply).

Preservation of land for public use (e.g., recreation or education) Preservation of an historically important land area

Protection of natural habitat Preservation of a certified historic structure

Preservation of open space

Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.


a	Total number of conservation easements .......................	2a
b	Total acreage restricted by conservation easements ..................	2b
c	Number of conservation easements on a certified historic structure included in (a) .....	2c
d	Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register ....................	2d

Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the tax year SchDMd Bullet

Number of states where property subject to conservation easement is located SchDMd Bullet

Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................

Yes No

Staff and volunteer hours devoted to monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet

Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet

Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .......................................

Yes No

In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.

If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.

If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:

(i)

Revenues included in Form 990, Part VIII, line 1 ........................ SchDMd Bullet

(ii)

Assets included in Form 990, Part X .............................. SchDMd Bullet

If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958) relating to these items:

Revenues included in Form 990, Part VIII, line 1 .......................... SchDMd Bullet

Assets included in Form 990, Part X ............................... SchDMd Bullet

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 52283D

Schedule D (Form 990) 2013

Page 2

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)

Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):

Public exhibition

Loan or exchange programs

Scholarly research

Other

Preservation for future generations

Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.

During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........

Yes No

Part IV

Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.

Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................

Yes No

If "Yes," explain the arrangement in Part XIII and complete the following table:


c	Beginning balance .................................	1c
d	Additions during the year ..............................	1d
e	Distributions during the year .............................	1e
f	Ending balance ...................................	1f

Did the organization include an amount on Form 990, Part X, line 21? .....................

Yes No

If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ........

Part V

Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.

		(a)Current year	(b)Prior year	b (c)Two years back	(d)Three years back	(e)Four years back
1a	Beginning of year balance ....
b	Contributions ........
c	Net investment earnings, gains, and losses
d	Grants or scholarships .....
e	Other expenditures for facilities and programs ........
f	Administrative expenses ....
g	End of year balance ......

Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:

Board designated or quasi-endowment SchDMd Bullet

Permanent endowment SchDMd Bullet

Temporarily restricted endowment SchDMd Bullet

The percentages in lines 2a, 2b, and 2c should equal 100%.

Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes

(i) unrelated organizations ........................

3a(i)

(ii) related organizations ........................

3a(ii)

If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........

Describe in Part XIII the intended uses of the organization's endowment funds.

Part VI

Land, Buildings, and Equipment. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11a. See Form 990, Part X, line 10.

Description of property		(a) Cost or other basis (investment)	(b)Cost or other basis (other)	(c) Accumulated depreciation	(d) Book value
1a	Land .................	807,737	37,588,922		38,396,659
b	Buildings ................	10,496,661	695,344,928	209,492,526	496,349,063
c	Leasehold improvements ............	2,878,464	463,126,984	410,597,079	55,408,369
d	Equipment ................		556,302,965	431,983,857	124,319,108
e	Other .................	921,448	81,218,526	633,492	81,506,482
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).).......					795,979,681

Schedule D (Form 990) 2013

Page 3

Part VII

InvestmentsOther Securities. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11b. See Form 990, Part X, line 12.

(a) Description of security or category (including name of security)	(b)Book value	(c) Method of valuation: Cost or end-of-year market value
(1)Financial derivatives
(2)Closely-held equity interests
(3)Other (A) PRIVATE EQUITY & REAL ESTATE	5,041,082,367	F
(B) NATURAL RESOURCES	357,303,568	F
(C) ALTERNATIVE INVESTMENTS	7,173,032,962	F






Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)	12,571,418,897

Part VIII

InvestmentsProgram Related. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11c. See Form 990, Part X, line 13.

(a) Description of investment		(b) Book value	(c) Method of valuation: Cost or end-of-year market value









Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)

Part IX

Other Assets. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11d. See Form 990, Part X, line 15.

(a) Description				(b) Book value









Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........

Part X

Other Liabilities. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.

1.(a) Description of liability		(b) Book value
Federal income taxes		0
SHORT POSITIONS		434,282,972
INVESTMENT PURCH. PENDING SALE		72,852,272
SWAP UNREALIZED LOSS		116,324,738
INVESTMENT MANAGEMENT FEES PAYABLE		16,514,317
DEFERRED COMPENSATION LIAB.		31,856,467
CURRENCY EXCH. CONTRACTS PAY.		14,837,397
EQUITY SWAP		4,214,878
CREDIT DEFAULT SWAP		630,755
DERIVATIVE LIABILITIES		1,388,370
PAY. REALIZED GAINS ON FUTURES		216,137
DEFERRED INCOME		1,227,710
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)		694,346,013
2. Liability for uncertain tax positions In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII ..................................................

Schedule D (Form 990) 2013

Page 4

Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return Complete if the organization answered 'Yes' to Form 990, Part IV, line 12a.
1	Total revenue, gains, and other support per audited financial statements .......			1	2,741,914,348
2	Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a	Net unrealized gains on investments ..........	2a	852,161,121
b	Donated services and use of facilities .........	2b
c	Recoveries of prior year grants ...........	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d .....................			2e	852,161,121
3	Subtract line 2e from line 1.....................			3	1,889,753,227
4	Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b .	4a	113,751,785
b	Other (Describe in Part XIII.) ...........	4b
c	Add lines 4a and 4b.......................			4c	113,751,785
5	Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ......			5	2,003,505,012

Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' to Form 990, Part IV, line 12a.
1	Total expenses and losses per audited financial statements ...........			1	1,049,314,159
2	Amounts included on line 1 but not on Form 990, Part IX, line 25:
a	Donated services and use of facilities ..........	2a
b	Prior year adjustments ..............	2b
c	Other losses ................	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d......................			2e
3	Subtract line 2e from line 1.....................			3	1,049,314,159
4	Amounts included on Form 990, Part IX, line 25, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b ..	4a	113,751,785
b	Other (Describe in Part XIII.) ............	4b
c	Add lines 4a and 4b.......................			4c	113,751,785
5	Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ......			5	1,163,065,944

Part XIII

Supplemental Information

Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.

Return Reference	Explanation

Schedule D (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE F(Form 990)

Department of the Treasury
Internal Revenue Service

Statement of Activities Outside the United States

Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16. Right pointing arrow large image

Attach to Form 990. Right pointing arrow large image

See separate instructions. Right pointing arrow large image

Information about Schedule F (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public Inspection

Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

General Information on Activities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 14b.

For grantmakers.Does the organization maintain records to substantiate the amount of its grants and

other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used

to award the grants or assistance? ...............................

Yes

For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.

Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)

(a) Region		(c) Number of employees, agents, and independent contractors in region	(d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region)	(e) If activity listed in (d) is a program service, describe specific type of service(s) in region	(f) Total expenditures for and investments in region
	Sub-Saharan Africa	1	Program Services	Medical Research	7,012,104
	Europe (Including Iceland and Greenland)		Grantmaking	Investigator Education	21,000
	Sub-Saharan Africa		Investments		24,369,515
	North America		Investments		160,828,189
	Europe (Including Iceland and Greenland)		Investments		1,247,603,923
	East Asia and the Pacific		Investments		671,072,336
	Central America and the Caribbean		Investments		3,772,271,505
	South America		Investments		104,489,515
	South Asia		Investments		85,266,920
	Russia and the Newly Independent States		Investments		4,234,730
	Middle East and North Africa		Investments		924,121






3a	Sub-total .....	1			6,078,093,858
b	Total from continuation sheets to Part I ...
c	Totals (add lines 3a and 3b)	1			6,078,093,858

For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2013

Schedule F (Form 990) 2013

Page 2

Part II

Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.

(c) Region	(d) Purpose of grant	(e) Amount of cash grant	(f) Manner of cash disbursement
Europe (Including Iceland and Greenland)	EDUCATION INVESTIGATOR	21,000	WT
Sub-Saharan Africa	MEDICAL RESEARCH HIV/TB	3,839,263	CHECK
Europe (Including Iceland and Greenland)	OPEN ACCESS PUBLICATIONS	1,643,513	WT

Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .... MediumBullet

Enter total number of other organizations or entities ....................... MediumBullet

Schedule F (Form 990) 2013

Schedule F (Form 990) 2013Page 3

Part III

Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.

Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance		(b) Region	(c) Number of recipients	(d) Amount of cash grant	(e) Manner of cash disbursement	(f) Amount of non-cash assistance	(g) Description of non-cash assistance	(h) Method of valuation (book, FMV, appraisal, other)

Schedule F (Form 990) 2013

Page 4

Part IV

Foreign Forms

Schedule F (Form 990) 2013

Page 5

Part V

Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).

ReturnReference	Explanation
Schedule F, Part 1, Line 2	Monitoring of foreign grant funds During its 2014 fiscal year, HHMI continued to support International Research Scholars selected through one or more competitions open to all eligible applicants. Eligibility requirements included, but were not limited to, a full-time appointment at a nonprofit scientific research organization in a country other than the United States, and a research focus on basic biological processes or disease mechanisms. Qualified applicants were evaluated by a panel of scientific experts with final selections made by HHMI leadership. The disbursement of grant funds to support the work of International Early Career Scientists and Senior International Research Scholars is made in accordance with all applicable U.S. laws. Funds are paid to an institutional account. In order to monitor the activities and productivity of the grants, each scientist is required to submit an annual progress report concerning his or her research and each grantee institution is required to submit annual financial reports. These reports are reviewed by HHMI staff. Site visits and audits are conducted if warranted and grantees attend scientific meetings of HHMI US-based scientists. HHMI makes regular expenditures as part of its commitment of over $70 million to support the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) over 10 years. As discussed in further detail on Schedule O, HHMI and the University of KwaZulu-Natal (UKZN) in South Africa have collaborated on establishing K-RITH as an international research center in Durban, South Africa. K-RITH's mission is the conduct of outstanding basic scientific research on tuberculosis (TB) and HIV, translating the scientific findings into new insights or tools to control the devastating co-epidemic of TB and HIV, and helping to train a new generation of scientists in Africa. K-RITH is an independent non-profit association incorporated under South African law. More information about K-RITH is available from its website, (http://www.k-rith.org/). As part of its oversight of the K-RITH project, HHMI receives regular, detailed financial and programmatic reporting from K-RITH of its spending of HHMI's financial support on at least a quarterly basis. In addition, HHMI has seconded an employee to serve as Acting Institute Director of K-RITH while K-RITH searches for a Director,and HHMI is represented on the K-RITH governing board. HHMI employees serve on various K-RITH advisory boards, make regular visits to K-RITH, and are in frequent contact with K-RITH staff to receive program and financial updates.

Schedule F (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

Schedule I
(Form 990)

Department of the Treasury
Internal Revenue Service

Grants and Other Assistance to Organizations,
Governments and Individuals in the United States

Complete if the organization answered "Yes," to Form 990, Part IV, line 21 or 22.
lBullet

Attach to Form 990
lBullet

Information about Schedule I (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number
59-0735717

Part I

General Information on Grants and Assistance

Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ....................................

Yes No

Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.

Part II

Grants and Other Assistance to Governments and Organizations in the United States. Complete if the organization answered "Yes" to
Form 990, Part IV, line 21, for any recipient that received more than $5,000. Part II can be duplicated if additional space is needed.

(a) Name and address of organization or government	(b) EIN	(c) IRC Code section if applicable	(d) Amount of cash grant	(h) Purpose of grant or assistance
(1) HOPE COLLEGE HOPE COLLEGE HOLLAND,MI49423	38-1381271	501(c)3	50,000	COLLEGES
(2) MACALESTER COLLEGE MACALESTER COLLEGE ST PAUL,MN55105	41-0693962	501(c)3	50,000	COLLEGES
(3) UNIV OF RICHMOND UNIV OF RICHMOND RICHMOND,VA23173	54-0505965	501(c)3	50,000	COLLEGES
(4) AMER SOCIETY FOR MICROBIOLOGY 1752 N ST NW WASHINGTON,DC20036	38-1616141	501(c)3	50,000	SUMMER INSTITUTE
(5) UNIV OF MINNESOTA UNIV OF MINNESOTA MINNEAPOLIS,MN55415	41-6007513	501(c)3	200,000	SUMMER INSTITUTE
(6) CAL POLY STATE UNIV CAL POLY STATE SAN LUIS OBISPO,CA93407	20-4927897	501(c)3	100,000	SUMMER INSTITUTE
(7) GRINNELL COLLEGE GRINNELL COLLEGE GRINNELL,IA50112	43-0680387	501(c)3	95,000	SUMMER INSTITUTE
(8) UNIV OF NORTH CAROLINA UNIV OF NC CHAPEL HILL,NC27599	56-6001393	501(c)3	2,375,000	MEYERHOFF ADAPTATION
(9) UNIV OF MARYLAND UMBC BALTIMORE,MD21201	52-6002033	501(c)3	3,000,000	MEYERHOFF ADAPTATION
(10) PENN STATE UNIV PENN STATE UNIV UNIVERSITY PARK,PA16802	24-6000376	501(c)3	2,375,000	MEYERHOFF ADAPTATION
(11) UC - SAN FRANCISCO UC - SAN FRANCISCO SAN FRANCISCO,CA94143	94-6036493	501(c)3	23,340	EXROP PROGR-HOUSING
(12) TRAVEL EXPS PAID BEHALF OF GRANTEES-INTL HOUSE 500 RIVERSIDE DR NEW YORK,NY10027	13-1624048		31,751	EXROP PROGR-HOUSING
(13) UNIV OF WASHINGTON UNIV OF WASHINGTON SEATTLE,WA98195	91-6001537	501(c)3	21,981	EXROP PROGR-HOUSING
(14) TRAVEL EXPS PAID BEHALF OF GRANTEES-YMCA 5 WEST 63RD ST 6TH FL NEW YORK,NY10023	13-1624228		7,650	EXROP PROGR-HOUSING
(15) STANFORD UNIV STANFORD UNIV PALO ALTO,CA94305	94-1156365	501(c)3	39,617	EXROP PROGR-HOUSING
(16) TRAVEL EXPS PAID BEHALF OF GRANTEES-UNITED 233 S WACKER DR CHICAGO,IL60606	74-2099724		5,488	EXROP PROGR-HOUSING
(17) UNIV OF MICHIGAN UNIV OF MICHIGAN ANN ARBOR,MI48109	38-6006309	501(c)3	15,560	EXROP PROGR-HOUSING
(18) UNIV OF COLORADO UNIV OF COLORADO BOULDER,CO80309	84-6000555	501(c)3	9,067	EXROP PROGR-HOUSING
(19) TRAVEL EXPS PAID BEHALF OF GRANTEES-AMR CORP 4333 AMON CARTER BLVD FORT WORTH,TX76155	75-1825172		7,748	EXROP PROGR-HOUSING
(20) MASS INST OF TECHNOLOGY MIT CAMBRIDGE,MA02139	04-2103594	501(c)3	9,230	EXROP PROGR-HOUSING
(21) UC - SAN DIEGO UCSD LA JOLLA,CA92093	95-6006144	501(c)3	7,342	EXROP PROGR-HOUSING
(22) TRAVEL EXPS PAID BEHALF OF GRANTEES-DELTA PO BOX 20706 ATLANTA,GA30354	58-0218548		13,076	EXROP PROGR-HOUSING
(23) JOHNS HOPKINS UNIV JOHNS HOPKINS UNIV BALTIMORE,MD21218	52-0595110	501(c)3	11,282	EXROP PROGR-HOUSING
(24) ROCKEFELLER UNIVERSITY ROCKEFELLER UNIVERSITY NEW YORK,NY10065	13-1624158	501(c)3	5,300	EXROP PROGR-HOUSING
(25) HARVARD UNIVERSITY HARVARD UNIVERSITY CAMBRIDGE,MA02138	04-2103580	501(c)3	39,477	EXROP PROGR-HOUSING
(26) TRAVEL EXPS PAID BEHALF OF GRANTEES-PREMIER HOTEL LONG WHARF DR NEW HAVEN,CT06511			25,899	EXROP PROGR-HOUSING
(27) BAYLOR COLLEGE OF MED BAYLOR COLLEGE OF MED HOUSTON,TX77030	74-1613878	501(c)3	5,838	EXROP PROGR-HOUSING
(28) MEMORIAL SLOAN KETTERING MEMORIAL SLOAN KETTERING NEW YORK,NY10021	13-1624182	501(c)3	5,038	EXROP PROGR-HOUSING
(29) AUDUBON NATURALIST SOC 8940 JONES MILL RD CHEVY CHASE,MD20815	53-0233715	501(c)3	150,000	LOCAL INITITATIVE
(30) CHESAPEAKE BAY FOUNDATION 162 PRINCE GEORGE ST ANNAPOLIS,MD21401	52-6065757	501(c)3	450,000	LOCAL INITITATIVE
(31) PG COUNTY PUBLIC SCHOOLS 14201 SCHOOL LANE UPPER MARLBORO,MD20772	52-6000992	501(c)3	127,500	LOCAL INITITATIVE
(32) LOUDOUN CTY PUBLIC SCHOOLS 21000 EDUCATION COURT LEESBURG,VA20176	54-6001395	501(c)3	3,000,000	PRECOLLEGE SCI-OTHER
(33) NEW YORK UNIV NYU NEW YORK,NY10003	13-5562308	501(c)3	30,000	NOVA
(34) WETA 3939 CAMPBELL AVENUE ARLINGTON,VA22206	53-0242992	501(c)3	125,000	GREATER PBS NEWSHOUR
(35) UNIV OF PITTSBURGH UNIV OF PITTSBURGH PITTSBURGH,PA15260	25-0965591	501(c)3	3,250,000	SEA
(36) UNIV OF MARYLAND UMBC BALTIMORE,MD21201	52-6002033	501(c)3	12,000	SEA
(37) RESEARCHAMERICA 1101 KING ST STE 520 CHANTILLY,VA20153	52-1609875	501(c)3	25,000	ASSESSMENT
(38) CHESAPEAKE BAY FOUNDATION 162 PRINCE GEORGE ST ANNAPOLIS,MD21401	52-6065757	501(c)3	50,000	LOCAL AREA
(39) BIOLOGICAL SCIENCES CURRICULUM STUDY CO STATE UNIV COLORADO SPRINGS,CO80918	84-0622557	501(c)3	297,495	BSCS-NOVA
(40) FOUNDATION FOR THE NIH 9650 ROCKVILLE PIKE BETHESDA,MD20814	52-1986675	501(c)3	100,800	LOCAL AREA
(41) THE CONVERSATION US INC 25 FAIRFAX ST WEST NEWTON,MA02465	46-0906774	501(c)3	500,000	SCIENCE JOURNALISM
(42) BROWN UNIVERSITY BROWN UNIVERSITY PROVIDENCE,RI02912	05-0258809	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(43) COLLEGE OF WILLIAM & MARY WILLIAMMARY WILLIAMSBURG,VA23187	54-6001718	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(44) DREXEL UNIVERSITY DREXEL UNIV PHILADELPHIA,PA19104	23-1352630	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(45) DUKE UNIVERSITY DUKE UNIV DURHAM,NC27706	56-0532129	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(46) EMORY UNIVERSITY EMORY UNIV ATLANTA,GA30322	58-0566256	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(47) FLORIDA INTERNATIONAL UNIV FLORIDA INTL UNIV MIAMI,FL33199	65-0177616	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(48) HOWARD UNIVERSITY HOWARD UNIV WASHINGTON,DC20059	53-0204707	501(c)3	1,400,000	UNIVERSITY(DOCTORAL)
(49) IOWA STATE UNIVERSITY IOWA STATE UNIV AMES,IA50011	42-6004224	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(50) LEHIGH UNIVERSITY LEHIGH UNIV BETHLEHEM,PA18015	24-0795445	501(c)3	1,900,000	UNIVERSITY(DOCTORAL)
(51) LOYALA UNIVERSITY LOYALA UNIV CHICAGO,IL60660	36-1408475	501(c)3	1,900,000	UNIVERSITY(DOCTORAL)
(52) MICHIGAN STATE UNIV MICHIGAN STATE UNIV LANSING,MI48824	38-6005984	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(53) NEW MEXICO STATE UNIV NEW MEXICO STATE UNIV LAS CRUCES,NM88003	85-6000401	501(c)3	1,900,000	UNIVERSITY(DOCTORAL)
(54) OKLAHOMA STATE UNIV OKLAHOMA STATE UNIV STILLWATER,OK74078	73-6017987	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(55) PORTLAND STATE UNIV PORTLAND STATE UNIV PORTLAND,OR97201	48-1278529	501(c)3	2,000,000	UNIVERSITY(DOCTORAL)
(56) RENSSELAER POLYTECHNIC INST RENSSELAER POLYTECHNIC INST TROY,NY12180	14-1340095	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(57) RICE UNIVERSITY RICE UNIVERSITY HOUSTON,TX77251	74-1109620	501(c)3	1,900,000	UNIVERSITY(DOCTORAL)
(58) SUNY - BINGHAMTON SUNY - BINGHAMTON BINGHAMTON,NY13902	14-1368361	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(59) UC - BERKELEY UC - BERKELEY BERKELEY,CA94720	94-6002123	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(60) UC - RIVERSIDE UC - RIVERSIDE RIVERSIDE,CA92521	95-6006142	501(c)3	2,400,000	UNIVERSITY(DOCTORAL)
(61) UC - SANTA BARBARA UC - SANTA BARBARA SANTA BARBARA,CA93106	95-6006145	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(62) UC - SANTA CRUZ UC - SANTA CRUZ SANTA CRUZ,CA95064	94-1539563	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(63) UNIV OF COLORADO UNIV OF COLORADO BOULDER,CO80309	84-6000555	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(64) UNIV OF HOUSTON UNIV OF HOUSTON HOUSTON,TX77204	74-6001399	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(65) UNIV OF IDAHO UNIV OF IDAHO MOSCOW,ID83844	82-6000945	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(66) UNIV OF KENTUCKY UNIV OF KENTUCKY LEXINGTON,KY40506	61-6033693	501(c)3	1,900,000	UNIVERSITY(DOCTORAL)
(67) UNIV OF MARYLAND UNIV OF MARYLAND COLLEGE PARK,MD21250	52-6002033	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(68) UNIV OF MIAMI UNIV OF MIAMI CORAL GABLES,FL33146	59-0624458	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(69) UNIV OF MICHIGAN UNIV OF MICHIGAN ANN ARBOR,MI48109	38-6006309	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(70) UNIV OF MINNESOTA UNIV OF MINNESOTA MINNEAPOLIS,MN55415	41-6007513	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(71) UNIV OF NEW ORLEANS UNIV OF NEW ORLEANS NEW ORLEANS,LA70148	72-0702000	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(72) UNIV OF PITTSBURGH UNIV OF PITTSBURGH PITTSBURGH,PA15260	25-0965591	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(73) UNIV OF SOUTH FLORIDA UNIV OF SOUTH FLORIDA TAMPA,FL33620	59-3102112	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(74) UNIV OF TEXAS UNIV OF TEXAS AUSTIN,TX78712	74-6000203	501(c)3	2,400,000	UNIVERSITY(DOCTORAL)
(75) UNIV OF TEXAS UNIV OF TEXAS EL PASO,TX76698	74-6000813	501(c)3	2,400,000	UNIVERSITY(DOCTORAL)
(76) UNIV OF WASHINGTON UNIV OF WASHINGTON SEATTLE,WA98195	91-6001537	501(c)3	1,500,000	UNIVERSITY(DOCTORAL)
(77) WESTERN MICHIGAN UNIVERSITY WESTERN MICHIGAN UNIV KALAMAZOO,MI49008	38-6007327	501(c)3	1,400,000	UNIVERSITY(DOCTORAL)
(78) YALE UNIVERSITY YALE UNIVERSITY NEW HAVEN,CT06520	06-0646973	501(c)3	1,200,000	UNIVERSITY(DOCTORAL)
(79) UC - SAN FRANCISCO UCSF San Francisco,CA94143	94-6036493	501 (c) 3	301,958	Transition Package
(80) DAMON RUNYON CANCER RESEARCH FOUNDATION DAMON RUNYON CANCER RES New York,NY10006	13-1933825	501(c)3	1,308,000	Postdoctoral Fellowships
(81) THE HELEN HAY WHITNEY FOUNDATION HELEN HAY WHITNEY New York,NY10956	13-1677403	501(c)3	1,278,000	Postdoctoral Fellowships
(82) JANE COFFIN CHILDS MEM FUND FOR MED RES JANE COFFIN CHILDS MEM New Haven,CT06510	06-6034840	501(c)3	1,310,400	Postdoctoral Fellowships
(83) LIFE SCIENCE RESEARCH FOUNDATION LIFE SCIENCE RESEARCH Baltimore,MD21218	52-1231801	501(c)3	1,432,000	Postdoctoral Fellowships
(84) UC - SAN DIEGO UC - SAN DIEGO LA JOLLA,CA92037	95-6006144	501(c)3	400,000	Transition Package
(85) THE SIMONS FOUNDATION INC SIMONS FOUNDATION NEW YORK,NY10010	13-3794889	501(c)3	1,611,500	Transition Package
(86) JOHNS HOPKINS UNIV JOHNS HOPKINS UNIV BALTIMORE,MD21218	52-0595110	501(c)3	199,911	Transition Package
(87) UNIV OF COLORADO UNIV OF COLORADO BOULDER,CO80309	84-6000555	501(c)3	151,031	Transition Package
(88) UNIV OF PENNSYLVANIA UNIV OF PENNSYLVANIA PHILADELPHIA,PA19104	23-1352685	501(c)3	134,571	Transition Package
(89) WASHINGTON UNIV WASHINGTON UNIV ST LOUIS,MO63130	43-0653611	501(c)3	1,096,192	Transition Package

Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................ Bullet Image

Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50055P

Schedule I (Form 990) 2013

Page 2

Part III

Grants and Other Assistance to Individuals in the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.

(a)Type of grant or assistance	(b)Number of recipients	(c)Amount of cash grant
(1) TRAVEL EXPS PAID BEHALF OF GRANTEES-DELTA	1	13,076
(2) JOHNS HOPKINS UNIV	1	11,282
(3) EXROP PROGRAM	106	556,530
(4) GILLIAM FELLOWSHIPS	38	465,000
(5) SCIENCE EDUCATION FELLOWSHIPS	1	21,930
(6) INTERNATIONAL PREDOCTORAL FELLOWSHIPS	105	4,744,500
(7) Medical Research Fellows	102	2,711,206
(8)

Part IV

Supplemental Information. Provide the information required in Part I, line 2, Part III, column (b), and any other additional information.

Return Reference	Explanation
SCHEDULE 1, PART 1, LINE 2	HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the U.S. through periodic national competitions for which select institutions are eligible to apply. Each program sets out specific criteria and objectives; proposals are evaluated by a panel of experts with the final selection made by HHMI leadership. The Institute also awards fellowships to international predoctoral students; to medical students seeking to conduct basic laboratory research; to doctoral students (the Gilliam Fellows), and to early career physician scientists. These grants are also awarded on a competitive basis. A small number of grants are awarded based on direct application to HHMI for specific initiatives directly related to science education. The disbursement of funds occurs principally through institutions: biomedical research institutions, universities, and colleges. HHMI grantees are required to file annual progress reports that detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds. These are subject to careful review and analysis by HHMI staff with more detailed review by the Institute auditors as warranted. The Institute continues to assess reporting requirements to ensure the quality and timeliness of both financial and programmatic reports. In addition to site visits made by HHMI staff, program directors meet on a regular basis to discuss their activities and share information about best educational practices.

Return Reference

Explanation

SCHEDULE 1, PART 1, LINE 2

HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the U.S. through periodic national competitions for which select institutions are eligible to apply. Each program sets out specific criteria and objectives; proposals are evaluated by a panel of experts with the final selection made by HHMI leadership. The Institute also awards fellowships to international predoctoral students; to medical students seeking to conduct basic laboratory research; to doctoral students (the Gilliam Fellows), and to early career physician scientists. These grants are also awarded on a competitive basis. A small number of grants are awarded based on direct application to HHMI for specific initiatives directly related to science education. The disbursement of funds occurs principally through institutions: biomedical research institutions, universities, and colleges. HHMI grantees are required to file annual progress reports that detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds. These are subject to careful review and analysis by HHMI staff with more detailed review by the Institute auditors as warranted. The Institute continues to assess reporting requirements to ensure the quality and timeliness of both financial and programmatic reports. In addition to site visits made by HHMI staff, program directors meet on a regular basis to discuss their activities and share information about best educational practices.

Schedule I (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

Schedule J
(Form 990)

Department of the Treasury
Internal Revenue Service

Compensation Information

For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet

Complete if the organization answered "Yes" to Form 990, Part IV, line 23.
SchJMediumBullet

Attach to Form 990. SchJMediumBullet

See separate instructions.
SchJMediumBullet

Information about Schedule J (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

Questions Regarding Compensation

Yes

Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.

First-class or charter travel Housing allowance or residence for personal use

Travel for companions Payments for business use of personal residence

Tax idemnification and gross-up payments Health or social club dues or initiation fees

Discretionary spending account Personal services (e.g., maid, chauffeur, chef)

If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain....

Yes

Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked in line 1a? ..

Yes

Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.

Compensation committee Written employment contract

Independent compensation consultant Compensation survey or study

Form 990 of other organizations Approval by the board or compensation committee

During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:

Receive a severance payment or change-of-control payment? ................

Yes

Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........

Participate in, or receive payment from, an equity-based compensation arrangement? .........

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.

Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.

For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:

The organization? ...........................

Any related organization? .........................

If "Yes," to line 5a or 5b, describe in Part III.

For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:

The organization? ...........................

Any related organization? .........................

If "Yes," to line 6a or 6b, describe in Part III.

For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............

Yes

Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................

Yes

If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................

Yes

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50053T

Schedule J (Form 990) 2013

Page 2

Part II

Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.

For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.

(A) Name and Title		(B) Breakdown of W-2 and/or 1099-MISC compensation			(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation reported as deferred in prior Form 990
(A) Name and Title		(i) Base compensation	(ii) Bonus & incentive compensation	(iii) Other reportable compensation	(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation reported as deferred in prior Form 990
(1)Robert Tjian PhDPresident	(i) (ii)	1,276,175 0	0	23,622	25,500	25,824	1,351,121 0
(2)Cheryl A MooreExecutive VP & COO	(i) (ii)	819,414 0	5,000	18,761	25,500	22,646	891,321 0
(3)Sean B Carroll PhDVP for Science Education	(i) (ii)	631,681 0	0	18,979	25,500	20,281	696,441 0
(4)Heidi E Henning EsqVP,General Counsel/Sec	(i) (ii)	485,122 0	0	18,631	25,500	21,564	550,817 0
(5)Mohamoud JibrellVP for Information Technology	(i) (ii)	288,314 0	0	12,430	25,500	24,818	351,062 0
(6)Nitin V KotakVP, CFO & Treasurer	(i) (ii)	376,911 0	5,000	19,132	25,500	21,171	447,714 0
(7)Erin K O'Shea PhDVP & Chief Sci Off	(i) (ii)	541,998 0	0	49,860	25,500	19,794	637,152 0
(8)Gerald M Rubin PhDVP&Exec Dir,Janelia Res Campus	(i) (ii)	682,218 0	0	22,011	25,500	90,323	820,052 0
(9)Kathy WyszynskiVP, Human Resources	(i) (ii)	251,508 0	5,000	18,068	25,500	9,011	309,087 0
(10)Landis ZimmermanVP & Chief Investment Officer	(i) (ii)	876,106 0	1,947,344	19,566	25,500	23,239	2,891,755 0
(11)Lauren T Spiliotes EsqDep GenCounsel/Asst Sec	(i) (ii)	325,007 0	0	18,904	25,500	22,892	392,303 0
(12)Susan S PlotnickAssistant Treasurer & Director	(i) (ii)	229,845 0	3,000	874	21,860	22,529	278,108 0
(13)Monique L MarcusAssistant Controller	(i) (ii)	177,695 0	3,000	628	17,082	20,460	218,865 0
(14)Richard A PenderMan Dir - US Equities	(i) (ii)	477,516 0	820,113	19,574	25,500	21,112	1,363,815 0
(15)Robert J Kolyer JrMan Dir - Diversified Assets	(i) (ii)	417,991 0	827,856	19,310	25,500	21,691	1,312,348 0
(16)Mark A BarnardMan Dir - Private Equities	(i) (ii)	369,500 0	636,182	19,445	25,500	22,375	1,073,002 0
(17)Stephen M KitsoulisMan Dir - Fixed Income	(i) (ii)	371,636 0	523,717	1,515	25,500	21,486	943,854 0
(18)Craig A Alexander EsqVP,Gen Counsel&Sec thru 4/13	(i) (ii)	232,559 0	0	319,822	15,628	6,659	574,668 0
(19)Thomas R Cech PhDInvestigator	(i) (ii)	576,231 0	0	25,315	25,500	22,829	649,875 0
(20)Jack E Dixon PhDVP/Chief Sci Off thru 6/13	(i) (ii)	449,766 0	0	16,251	25,500	14,313	505,830 0
(21)Anil MadhokMan Dir - Investments & COO	(i) (ii)	335,658 0	636,076	17,304	25,500	19,834	1,034,372 0
(22)Matthew R LeeMan Dir-Inv. Strtgy thru 8/13	(i) (ii)	221,660 0	599,313	15,209	19,737	13,150	869,069 0
(23)Michael B ShafferDir/Senior Trader thru 12/13	(i) (ii)	296,117 0	283,478	17,824	22,979	19,750	640,148 0
(24)William R Bishai MD PhDLab Head	(i) (ii)	408,511 0	0	172,631	25,500	20,236	626,878 0
(25)Eric R Kandel MDSenior Investigator	(i) (ii)	543,649 0	0	26,484	25,500	28,061	623,694 0

Schedule J (Form 990) 2013

Page 3

Part III

Supplemental Information

Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II.
Also complete this part for any additional information.

Return Reference	Explanation
Part 1 Line 1a	First-class travel: Under HHMI policies, HHMI reimburses its Trustees, President, Vice Presidents, and certain advisory group members for the reasonable cost of airfare at one class above coach for domestic or international flights of three hours or more. If a particular aircraft does not have a business class section, one class above coach may be first class. In this case HHMI would reimburse the traveling Trustee or officer for the reasonable cost of first-class travel if the flight is three hours or more. As an alternative, HHMI may reimburse for the cost of coach airfare plus the cost of an upgrade to travel at one level above coach for a flight of three hours or more. Such travel reimbursements are excluded from taxable compensation in accordance with HHMI's accountable plan. During fiscal year 2014, four officers and five trustees flew first class. Housing for personal use: HHMI's President currently resides in an HHMI-owned apartment on the headquarters campus, for which he pays HHMI at a fair market rental rate. Because HHMI's President is also required to spend time at HHMI's Janelia campus, where he runs a research laboratory as well as attends meetings and participates in conferences, HHMI makes a one-bedroom apartment available to him at that location. HHMI's Vice President and Executive Director, Janelia Research Campus is required as a condition of employment to reside on the Janelia campus in housing built for that purpose. HHMI's Vice President and Chief Scientific Officer currently resides in an HHMI-owned house on the headquarters campus, for which she pays HHMI at a fair market rental rate. The Institute provides a housing assistance program for one individual who relocated to take a position with HHMI, which may be used to cover such individuals' mortgage or rent payments. In each case, the subsidy is treated as additional taxable compensation. Travel for companions: Under HHMI's moving expense reimbursement policy, if an employee is relocating at HHMI's request, HHMI may reimburse for up to two househunting trips by the relocating employee and members of his or her household. Under this policy, HHMI reimbursed an officer who was relocating at HHMI's request for househunting travel by a companion. The reimbursement was treated as additional taxable compensation. Tax gross-up payments: Under HHMI's moving expense reimbursement policy, if an employee is relocating at HHMI's request, HHMI will ordinarily provide a tax gross-up for the reimbursable moving expenses that must be treated as taxable to the employee. HHMI continued to follow this standard practice during the 2014 fiscal year; including with respect to payments made to one officer. Internationally-assigned employees may receive tax gross-ups in respect of certain tax compliance and personal expenses incurred because of, and during, their overseas assignment. One highly compensated employee received payments pursuant to this standard practice during the 2014 fiscal year, all of which were treated as taxable compensation.
Part I Line 4a	Former VP, General Counsel & Secretary - $319,431
Part I Line 7	HHMI has an incentive compensation plan for its senior investment staff under which a portion of their compensation is determined based on performance of HHMI's portfolio against market benchmarks. HHMI also makes one-time payments to some of its other employees, including but not limited to officers, in recognition of exceptional performance.
Part 1, Line 8	When recruiting individuals for high-level positions, HHMI typically enters into initial contracts. HHMI has entered into initial contracts with its President and a number of Vice Presidents. HHMI's standard practice is to have independent compensation consultants regularly review and confirm the reasonableness of compensation of HHMI's officers and key employees, regardless of whether the initial contract exception applies.

Schedule J (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

Schedule K
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information on Tax Exempt Bonds

Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet

Attach to Form 990. SchKMediumBullet

See separate instructions.
SchKMediumBullet

Information about Schedule K (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number
59-0735717

Part I

Bond Issues

(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	(g) Defeased		(h) On behalf of issuer		(i) Pool financing
(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	Yes	No	Yes	No	Yes	No
A	Loudoun County IDA	52-1310230	545910AL5	02-27-2003	500,000,000	FINANCE CONSTRUCTION OF JANELIA RE		X		X		X
B	Loudoun Cty IDA	52-1310230	545910AP6	10-02-2009	23,000,000	FINANCE CONTRUCTION OF JANELIA APA		X		X		X
C	MEDCO	52-1376562	574205FY1	02-15-2008	83,500,000	FINANCE CONSTRUCTION OF HQ EXPANSI		X		X		X
D	Medco	52-1376562	574205FZ8	05-15-2008	76,500,000	REFUNDING OF ISSUE TO FINANCE HQ C		X		X		X
	LOUDOUN COUNTY IDA	52-1310230	545910AQ4	05-15-2013	33,130,000	FINANCE CONTRUCTION OF JANELIA APA		X		X		X

Part II

Proceeds

	A		B		C		D
	1 Amount of bonds retired . . . . . . . . . . . . . .	0		0		0		0
2 Amount of bonds legally defeased . . . . . . . . . . .	0		0		0		0
3 Total proceeds of issue . . . . . . . . . . . . . .	534,028,000		23,022,042		84,953,297		76,500,000
4 Gross proceeds in reserve funds . . . . . . . . . . . .	0		0		0		0
5 Capitalized interest from proceeds . . . . . . . . . . .	54,203,000		904,914		5,954,687		0
6 Proceeds in refunding escrows . . . . . . . . . . . .	0		0		0		0
7 Issuance costs from proceeds . . . . . . . . . . . .	200,000		0		631,673		0
8 Credit enhancement from proceeds . . . . . . . . . . .	0		0		0		0
9 Working capital expenditures from proceeds . . . . . . . . .	0		43,205		0		0
10 Capital expenditures from proceeds . . . . . . . . . . .	479,625,000		22,073,823		78,366,937		0
11 Other spent proceeds . . . . . . . . . . . . . .	0		0		0		76,500,000
12 Other unspent proceeds . . . . . . . . . . . . . .	0		0		0		0
13 Year of substantial completion . . . . . . . . . . . .	2006		2011		2010		1993
	Yes	No	Yes	No	Yes	No	Yes	No
14 Were the bonds issued as part of a current refunding issue? . . . . .		X		X		X	X
15 Were the bonds issued as part of an advance refunding issue? . . . . .		X		X		X		X
16 Has the final allocation of proceeds been made? . . . . . . . .	X		X		X		X
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . .	X		X		X		X

Part III

Private Business Use

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .		X		X		X
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . .		X		X		X

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50193E

Schedule K (Form 990) 2013

Page 2

Part III

Private Business Use (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . .	X		X		X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?	X		X		X
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . .	X			X		X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property?	X		X		X
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . .	0 %		0 %		0 %		0 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . .
6 Total of lines 4 and 5 . . . . . . . . . . . . .
7 Does the bond issue meet the private security or payment test? . . . . .		X		X		X
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .		X		X		X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of.
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .		X		X		X
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under Regulations sections 1.141-12 and 1.145-2? . . . . . . .		X		X		X

Part IV

Arbitrage

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Has the issuer filed Form 8038-T? . . . . .	X			X		X	X
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . .	X		X			X
b Exception to rebate? . . . . . . . .		X		X		X
c No rebate due? . . . . . . . .	X				X
If you checked "No rebate due" in line 2c, provide in Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . .	X		X		X		X
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?	X		X		X		X
b Name of provider . . . . . . . . .	WELLS FARGO		JP MORGAN CHASE		JP MORGAN
c Term of hedge . . . . . . . . . .	20.		30.		30.		30.
d Was the hedge superintegrated? . . . .		X		X		X		X
e Was the hedge terminated? . . . . . .		X		X		X		X

Schedule K (Form 990) 2013

Page 3

Part IV

Arbitrage (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .		X		X		X		X
b Name of provider . . . . . . . . .	0		0		0		0
c Term of GIC . . . . . . . . . .
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .		X		X		X		X
7 Has the organization established written procedures to monitor the requirements of section 148? . . .	X		X		X		X

Part V

Procedures To Undertake Corrective Action

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?		X		X		X		X

Part VI

Supplemental Information. Provide additional information for responses to questions on Schedule K (see instructions).

Return Reference

Explanation

Schedule K, Part VI

PART I The bond issued February 27, 2003 and described in A also includes CUSIPS 545910AM3, 545910AG6, 545910AH4,545910AJ0, and 545910AK7. PART II, Line 3 The bonds issued on 2/27/2003, 10/2/2009 and 2/15/2008 included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV For the bond issued on 2/27/2003 $375 million notional amount of the $500 million notional amount of swaps pertaining to this bond were integrated. The other counterparties pertaining to the bond issued on 2/27/2003 were Bank of America (30 years), Goldman Sachs (30 years)and JP Morgan (30 years). PART IV, line 2c for the bond issued on 2/23/2008, February 2013. PART IV, Line 4a Yes, In part for the bonds issued on 2/27/2003, 10/2/2009, 2/15/2008 and 5/15/2008.

Schedule K, Part VI

PART II, Line 3 The bonds issued on 5/15/2013 included interest income that made up the difference between the amount of the bond issue and the total proceeds. PART IV, Line 4a Yes, In part for the bond issued on 5/15/2013.

Schedule K (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

Schedule K
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information on Tax Exempt Bonds

Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet

Attach to Form 990. SchKMediumBullet

See separate instructions.
SchKMediumBullet

Information about Schedule K (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

Name of the organization
HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number
59-0735717

Part I

Bond Issues

(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	(g) Defeased		(h) On behalf of issuer		(i) Pool financing
(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	Yes	No	Yes	No	Yes	No
A	Loudoun County IDA	52-1310230	545910AL5	02-27-2003	500,000,000	FINANCE CONSTRUCTION OF JANELIA RE		X		X		X
B	Loudoun Cty IDA	52-1310230	545910AP6	10-02-2009	23,000,000	FINANCE CONTRUCTION OF JANELIA APA		X		X		X
C	MEDCO	52-1376562	574205FY1	02-15-2008	83,500,000	FINANCE CONSTRUCTION OF HQ EXPANSI		X		X		X
D	Medco	52-1376562	574205FZ8	05-15-2008	76,500,000	REFUNDING OF ISSUE TO FINANCE HQ C		X		X		X
	LOUDOUN COUNTY IDA	52-1310230	545910AQ4	05-15-2013	33,130,000	FINANCE CONTRUCTION OF JANELIA APA		X		X		X

Part II

Proceeds

	A		B		C		D
	1 Amount of bonds retired . . . . . . . . . . . . . .	0		0		0		0
2 Amount of bonds legally defeased . . . . . . . . . . .	0		0		0		0
3 Total proceeds of issue . . . . . . . . . . . . . .	534,028,000		23,022,042		84,953,297		76,500,000
4 Gross proceeds in reserve funds . . . . . . . . . . . .	0		0		0		0
5 Capitalized interest from proceeds . . . . . . . . . . .	54,203,000		904,914		5,954,687		0
6 Proceeds in refunding escrows . . . . . . . . . . . .	0		0		0		0
7 Issuance costs from proceeds . . . . . . . . . . . .	200,000		0		631,673		0
8 Credit enhancement from proceeds . . . . . . . . . . .	0		0		0		0
9 Working capital expenditures from proceeds . . . . . . . . .	0		43,205		0		0
10 Capital expenditures from proceeds . . . . . . . . . . .	479,625,000		22,073,823		78,366,937		0
11 Other spent proceeds . . . . . . . . . . . . . .	0		0		0		76,500,000
12 Other unspent proceeds . . . . . . . . . . . . . .	0		0		0		0
13 Year of substantial completion . . . . . . . . . . . .	2006		2011		2010		1993
	Yes	No	Yes	No	Yes	No	Yes	No
14 Were the bonds issued as part of a current refunding issue? . . . . .		X		X		X	X
15 Were the bonds issued as part of an advance refunding issue? . . . . .		X		X		X		X
16 Has the final allocation of proceeds been made? . . . . . . . .	X		X		X		X
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . .	X		X		X		X

Part III

Private Business Use

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .		X		X		X
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . .		X		X		X

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50193E

Schedule K (Form 990) 2013

Page 2

Part III

Private Business Use (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . .	X		X		X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?	X		X		X
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . .	X			X		X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property?	X		X		X
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . .	0 %		0 %		0 %		0 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . .
6 Total of lines 4 and 5 . . . . . . . . . . . . .
7 Does the bond issue meet the private security or payment test? . . . . .		X		X		X
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .		X		X		X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of.
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .		X		X		X
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under Regulations sections 1.141-12 and 1.145-2? . . . . . . .		X		X		X

Part IV

Arbitrage

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Has the issuer filed Form 8038-T? . . . . .	X			X		X	X
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . .	X		X			X
b Exception to rebate? . . . . . . . .		X		X		X
c No rebate due? . . . . . . . .	X				X
If you checked "No rebate due" in line 2c, provide in Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . .	X		X		X		X
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?	X		X		X		X
b Name of provider . . . . . . . . .	WELLS FARGO		JP MORGAN CHASE		JP MORGAN
c Term of hedge . . . . . . . . . .	20.		30.		30.		30.
d Was the hedge superintegrated? . . . .		X		X		X		X
e Was the hedge terminated? . . . . . .		X		X		X		X

Schedule K (Form 990) 2013

Page 3

Part IV

Arbitrage (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .		X		X		X		X
b Name of provider . . . . . . . . .	0		0		0		0
c Term of GIC . . . . . . . . . .
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .		X		X		X		X
7 Has the organization established written procedures to monitor the requirements of section 148? . . .	X		X		X		X

Part V

Procedures To Undertake Corrective Action

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?		X		X		X		X

Part VI

Supplemental Information. Provide additional information for responses to questions on Schedule K (see instructions).

Return Reference

Explanation

Schedule K, Part VI

Schedule K (Form 990) 2013

Additional Data

Software ID:
Software Version:

- TIN:

Schedule L
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service

Transactions with Interested Persons

Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet

Attach to Form 990 or Form 990-EZ. MediumBullet

See separate instructions.
MediumBullet

Information about Schedule L (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

Excess Benefit Transactions (section 501(c)(3) and section 501(c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.

1(a) Name of disqualified person	(c) Description of transaction	(d) Corrected?
1(a) Name of disqualified person	(c) Description of transaction	Yes	No

Enter the amount of tax incurred by organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image

Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image

Part II

Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22

(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	(d) Loan to or from the organization?		(e)Original principal amount	(f)Balance due	(g) In default?		(h) Approved by board or committee?		(i)Written agreement?
(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	To	From	(e)Original principal amount	(f)Balance due	Yes	No	Yes	No	Yes	No






Total ...... $

Part III

Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of assistance	(d) Type of assistance	(e) Purpose of assistance

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50056A

Schedule L (Form 990 or 990-EZ) 2013

Page 2

Part IV

Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of transaction	(d) Description of transaction	(e) Sharing of organization's revenues?
(a) Name of interested person		(c) Amount of transaction	(d) Description of transaction	Yes	No
(1) American Express Company	Shared Trustee/Director	193,647	see Supplemental Information		No
(2) Bank of America Corporation	Shared Trustee/Director	15,312,201	see Supplemental Information		No

Part V

Supplemental Information
Provide additional information for responses to questions on Schedule L (see instructions).

Return Reference	Explanation
Part IV, Line d	A trustee of HHMI is also a director of American Express Company. HHMI paid American Express Company for travel and related services provided to HHMI in the ordinary course of business. A trustee of HHMI is also a director of Bank of America Corporation. HHMI paid Bank of America for banking and related services provided to HHMI in the ordinary course of business.

Schedule L (Form 990 or 990-EZ) 2013

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service

Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet

Attach to Form 990 or 990-EZ.
MediumBullet

Information about Schedule O (Form 990 or 990-EZ) and its instructions is at
www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public
Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Return Reference	Explanation
Core Form, Part V, Line 4b	Authority over Financial Account in a Foreign Country HHMI has signature authority over investment accounts in the following foreign countries through their custodian, Bank of New York Mellon: ARGENTINA AUSTRALIA AUSTRIA BELGIUM BERMUDA BRAZIL CANADA CHILE CHINA COLOMBIA CYPRUS CZECH REPUBLIC DENMARK EGYPT ESTONIA FINLAND FRANCE GERMANY GREECE HONG KONG HUNGARY INDIA INDONESIA IRELAND ISRAEL ITALY JAPAN JORDAN KENYA LUXEMBOURG MALAYSIA MAURITIUS MEXICO MOROCCO NETHERLANDS NEW ZEALAND NIGERIA NORWAY PERU PHILIPPINES POLAND PORTUGAL ROMANIA RUSSIA SINGAPORE SLOVENIA SOUTH AFRICA SOUTH KOREA SPAIN SRI LANKA SWEDEN SWITZERLAND TAIWAN THAILAND TURKEY UKRAINE UNITED ARAB EMIRATES UNITED KINGDOM URUGUAY VENEZUELA ZIMBABWE. HHMI also has direct signature authority in Mauritius.
Core Form, Part VI, Section B, Line 11A	Description of 990 Review Process The Howard Hughes Medical Institute's Form 990 is initially prepared by its Tax Compliance Department, in coordination with other HHMI departments as needed. The draft return is reviewed by senior management of HHMI and by attorneys in HHMI's Office of the General Counsel. Following these reviews and the resolution of any questions that have been raised, the draft return is reviewed by HHMI's outside tax preparer. Finally, a copy of the return is provided to the members of HHMI's Board of Trustees so that they have an opportunity to review and comment on the return before it is filed.
Conflict of Interest Policy	In addition to HHMI's code of conduct, which addresses conflicts of interest and applies to all HHMI employees, officers, Trustees, and advisors, HHMI has specific conflict of interest policies for different categories of personnel. Under the HHMI policies that apply to Trustees, officers, and key employees, these individuals must disclose annually interests that could give rise to conflicts of interest, and must certify annually their compliance with the conflict of interest policy that applies to them. Annual disclosures and certifications are reviewed by HHMI's Office of the General Counsel, and by other HHMI managers as needed. The conflict of interest policy covering HHMI's Trustees also requires each Trustee to disclose to the other Trustees any actual or apparent conflict of interest with respect to a proposed HHMI transaction. If the other Trustees decide that there is only the appearance of a conflict of interest, and that it could not reasonably be considered to affect the independent, unbiased judgment of the disclosing Trustee with respect to the transaction at issue, no further action is required to address the apparent conflict. In all other cases, including all actual conflicts of interest, the disclosing Trustee is not permitted to participate in the deliberation or decision regarding the transaction under consideration, and must leave the room during the deliberation and vote. The conflict of interest policy covering HHMI's officers and key employees requires each covered individual to obtain supervisory approval up to the level of HHMI's President before entering into an affiliation with or acquiring an interest of 1% or more in any entity that is or may become a recipient of HHMI funds. HHMI's President, in consultation with HHMI's General Counsel, may permit the affiliation or interest if it would not interfere with the covered individual's performance of his or her HHMI responsibilities, would not create the appearance of a conflict of interest, and would be consistent with sound business judgment. HHMI's President may set conditions on approval, for example that there be no remuneration to the covered individual. Proposed affiliations and interests of 1% or more of HHMI's President are subject to the approval of the Chairman of the Trustees.
Core Form, Part VI, Section B, Lines 15a-b	Process for determining compensation The compensation for HHMI's President, other officers, and key employees is set using the following procedures. Every other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent compensation consultants to conduct a study of comparable market data. The study includes data for HHMI's President, other officers, and key employees. The independent compensation consultants also provide an opinion regarding the reasonableness of the compensation arrangements for the positions included in the study. The study includes comparable market data for all components of compensation for each person covered by the study, including base salary, incentive compensation (if any), and benefits. The Committee relies on the market data and opinion provided by the compensation consultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers and key employees. The decision is made by independent Trustees. Any Trustee who has a conflict of interest with respect to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, and leave the meeting room during the debate and voting on it. In the alternate years when a study is not done, the Audit and Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit increases for HHMI employees, including senior management, is reasonable compared with generally prevailing compensation increases in the market over the past year. The Committee relies on this advice in recommending compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in making compensation decisions. Recusal procedures are the same in as in the years when a study is done. In each year, minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for approval at the next meeting. Approved minutes are kept in HHMI's records. All minutes include the date of the meeting, identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees with a conflict of interest. The comparability studies and opinions relied on at the meeting are referenced in the minutes, and copies of these materials are also kept in HHMI's records. HHMI's Board of Trustees followed this process in August 2013 in determining compensation for the following positions: President; Vice Presidents; and Managing Directors - Investments.
Core Form, Part VI, Section C, Line 19	Governing documents etc available to the public HHMI's practice has been to make a copy of its charter and by-laws available on request. HHMI's code of conduct, which addresses conflicts of interest, is available to the public on the HHMI web site. A downloadable copy of HHMI's most recent audited financial statements is also available to the public on the web site. In addition, HHMI publishes "Year in Review" that provides a summary of each year's activity, expenditures, and financial performance; this publication is distributed in print and is posted on the HHMI web site.
Part III, Program Service, line 4a - Medical Research	Statement 1 4A: Medical Research (A) The HHMI Investigator Program (B) Janelia Farm Research Campus (C) Highlights from HHMI Research Laboratories (Fiscal Year 2014) (D) Honors and Awards Received by HHMI Scientists (A) The HHMI Investigator Program The Howard Hughes Medical Institute's approach to biomedical research can be summarized in three words: people, not projects. By employing scientists as HHMI investigators - rather than awarding research grants - the Institute provides long-term, flexible funding that enables its researchers to pursue their scientific interests wherever they lead. HHMI believes that scientists of exceptional talent and imagination will make fundamental discoveries of lasting scientific value and benefit to humanity if they are given the resources, time, and freedom to pursue challenging questions. The Institute nurtures the creativity and intellectual daring of scientists who are willing to set aside conventional wisdom or the "easy" question for a fundamental problem that may take many years to solve. Among the characteristics that distinguish this group of scientists are qualities such as creativity, a penchant for risk-taking, and a commitment to discovery, productivity, and perseverance. This unique research model is an imaginative and powerful alternative to funding biomedical research through grants. The HHMI Investigator Program employs more than 310 HHMI researchers, among them 17 Nobel laureates and 169 members of the National Academy of Sciences. In the last decade, 10 HHMI investigators have won Nobel Prizes. HHMI investigators direct Institute research laboratories on the campuses of 70 universities and other research organizations throughout the United States. Since the early 1990s, investigators have been selected through rigorous national competitions. The Institute solicits applications directly from scientists at medical schools and other research institutions in the United States, with the aim of identifying those who have the potential to make significant contributions to science. HHMI employs an open application process to ensure that it is selecting its researchers from a broad and deep pool of scientific talent. In 2014, HHMI announced a national open competition to appoint up to 25 new biomedical researchers as HHMI investigators in 2015. The initiative represents an investment of approximately $150 million in basic biomedical research over the next five years. The HHMI investigator competition is open to basic researchers and physician scientists at more than 200 eligible institutions who study significant biological problems in all of the biomedical disciplines, including plant biology, as well as in adjacent fields such as evolutionary biology, biophysics, chemical biology, biomedical engineering, and computational biology. Those selected in this competition will receive a five-year appointment to HHMI, which is renewable pending favorable scientific review. Once selected, HHMI investigators continue to be based at their home institutions, typically leading a research group of 10-25 students, postdoctoral associates and technicians, but they become Institute employees and are supported by HHMI field staff. With freedom and flexibility come high expectations for intellectual output. HHMI demands creativity and innovation. Investigators are expected to work at the frontiers of their chosen field, to ask fundamental questions, and to take risks. HHMI prizes impact over publication volume in its merit-based renewal of investigator appointments and recognizes that some areas of research will proceed more slowly than others. The renewal of an investigator's five-year appointment is dependent on a rigorous peer-review process that centers on an evaluation of the originality and creativity of the investigator's work relative to others in the field, as well as the investigator's plan for future research. Those investigators whose appointments are not renewed remain HHMI employees for multi-year phase-out periods to facilitate their ability to obtain other funding for their research. Highlights of research conducted, and awards received, by HHMI scientists during its year ended August 31, 2014 are included below. (B) Janelia Research Campus The Janelia Research Campus offers a collaborative research environment for scientists across an array of disciplines who have focused on two broad scientific areas of scientific inquiry: the identification of general principles governing how neuronal circuits process information and development of imaging technologies and computational methods that support image analysis. In the current fiscal year, there were 54 laboratory heads at Janelia, in addition to supporting graduate students and other scientific trainees, visiting scientists, and a vibrant scientific conference program. During this fiscal year, HHMI and the Gordon and Betty Moore Foundation (GBMF) announced the establishment of an Advanced Imaging Center at the Janelia Research Campus that will make leading-edge imaging technologies more widely available to academic scientists before the instruments are available commercially. With total startup funds of $4.9 million over the first two years, the new center aims to make an immediate impact by providing broader access to potentially transformative imaging technology developed at Janelia. Also this year, HHMI, the Allen Institute for Brain Science, the Gatsby Charitable Foundation, the Wellcome Trust, and UCL (University College London) announced a $5.5 million (4.2 million Euro) collaboration to develop and manufacture a state-of-the-art device for detecting neural activity in animal brains. The research will be conducted in conjunction with imec, a world-leading nanoelectronics research center in Leuven, Belgium. The proposed device builds on technology currently used to detect extracellular electrical activity in the brains of living animals, but incorporates recording electrodes at a much higher density. This allows researchers to collect more data and better interpret their results. Over the 38-month project, the group will develop and test the technology, then identify a version that can be manufactured and made available for use by the research community. (C) Highlights from HHMI Research Laboratories (Fiscal Year 2014) 1) Changing the Emotional Association of Memories Susumu Tonegawa, Massachusetts Institute of Technology http://www.hhmi.org/news/changing-emotional-association-memories By manipulating neural circuits in the brain of mice, scientists have altered the emotional associations of specific memories. The research reveals that the connections between the part of the brain that stores contextual information about an experience and the part of the brain that stores the emotional memory of that experience are malleable. Altering those connections can transform a negative memory into a positive one. 2) How the Brain Makes Sense of Spaces, Large and Small Albert Lee, Janelia Research Campus http://www.hhmi.org/news/how-brain-makes-sense-spaces-large-and-small When an animal encounters a new environment, the neurons in its brain that are responsible for mapping out the space are ready for anything. Scientists at HHMI's Janelia Research Campus examined neuronal activity in rats as they explored an unusually large maze for the first time. The researchers found that neurons in the brain's hippocampus, where information about people, places, and events is stored, each contribute to an animal's mental map at their own rate. Some neurons begin to associate themselves with the new space immediately, while others hold back, contributing only if the space expands beyond a size that can be represented by the first-line neurons. 3) Gene Technique Identifies Hidden Causes of Brain Malformation Christopher A. Walsh, Boston Children's Hospital http://www.hhmi.org/news/gene-technique-identifies-hidden-causes-brain-mal formation HHMI scientists have developed a strategy for finding disease-causing mutations that lurk in only a small fraction of the body's cells. Such mutations can cause significant problems, but cannot be detected with traditional methods of genetic testing, as well as newer, more costly genome sequencing technologies. The scientists used the technique to find disease-causing mutations in patients with brain malformations whose genetic causes were unknown despite previous testing.
Part III, Program Service, line 4a - Medical Research	(C) Highlights from HHMI Research Laboratories (Fiscal Year 2014) continued 4) New Tools Help Neuroscientists Analyze Big Data Jeremy Freeman, Janelia Research Campus Misha Ahrens, Janelia Research Campus http://www.hhmi.org/news/new-tools-help-neuroscientists-analyze-big-data Big data can mean big headaches for scientists. A new library of open source software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation-if a single workstation could do it at all. 5) Reconstructing an Animal's Development Cell by Cell Philipp Keller, Janelia Research Campus Kristin Branson, Janelia Research Campus http://www.hhmi.org/news/reconstructing-animals-development-cell-by-cell Advances in imaging technology are transforming how scientists see the cellular universe, showing the form and movement of once grainy and blurred structures in stunning detail. But extracting the torrent of information contained in those images often surpasses the limits of existing computational and data analysis techniques, leaving scientists less than satisfied. Researchers at HHMI's Janelia Research Campus have developed a way around that problem by creating a new computational method to rapidly track the three-dimensional movements of cells in such data-rich images. 6) Single DNA Tweak Leads to Blond Hair David Kingsley, Stanford University http://www.hhmi.org/news/single-dna-tweak-leads-blond-hair A single-letter change in the genetic code is enough to generate blond hair in humans, in dramatic contrast to our dark-haired ancestors. An analysis by HHMI scientists has pinpointed that change, which is common in the genomes of Northern Europeans, and shown how it fine-tunes the regulation of an essential gene. 7) Researchers Build New Off Switch to Shut Down Neural Activity Karl Deisseroth, Stanford University http://www.hhmi.org/news/researchers-build-new-switch-shut-down-neural-act ivity In the field of optogenetics, light-activated ion channels, such as channelrhodopsins, have become powerful tools for using light to turn on neural activity. Scientists have not had an equally precise and efficient way to inhibit neurons using light. HHMI researchers have developed an ion channel, based on the structure of channelrhodopsin, which can be used to inhibit neurons in which the channel is genetically expressed. 8) New Technique Takes Cues from Astronomy and Ophthalmology to Sharpen Microscope Images Eric Betzig, Janelia Research Campus http://www.hhmi.org/news/new-technique-takes-cues-astronomy-and-ophthalmol ogy-sharpen-microscope-images Biological samples bend light in unpredictable ways, returning difficult-to-interpret information to the microscope. Using a form of adaptive optics, Janelia scientists developed a microscopy technique that can rapidly correct for these distortions and sharpen high-resolution images over large volumes of tissue. 9) Humans Can Distinguish at Least One Trillion Different Odors Leslie Vosshall, The Rockefeller University http://www.hhmi.org/news/humans-can-distinguish-least-one-trillion-differe nt-odors How many different scents can humans detect? It's generally been accepted that humans can discriminate between 10,000 different odors-although that number was first proposed decades ago and not backed by data. HHMI scientists directly tested the olfactory capacity of human volunteers and showed that humans are equipped to tell the difference between at least one trillion different odors. 10) A Crisper View of DNA-Snipping Enzyme Jennifer A. Doudna, University of California, Berkeley Eva Nogales, University of California, Berkeley http://www.hhmi.org/news/crisper-view-dna-snipping-enzyme HHMI scientists have created a portrait of a DNA-snipping protein called Cas9 that reveals how the enzyme reshapes itself when it associates with an RNA molecule, creating a channel that lets it find and cleave its DNA target. The protein-RNA complex is a key component of a primitive bacterial immune system called CRISPR, and is also being used by researchers to cut specific DNA sequences in the laboratory for genome editing applications. 11) Undruggable Mutation Meets Its Match Kevan Shokat, University of California, San Francisco http://www.hhmi.org/news/undruggable-mutation-meets-its-match For more than 30 years, researchers have tried to develop a drug to inhibit K-Ras, the most commonly mutated oncogene in human cancers. HHMI researchers have recently identified a "pocket," or binding site, and designed a chemical compound that fits inside this pocket and inhibits the normal activity of mutant K-Ras. The research may lead to new drug designs that inhibit this common cancer mutation. 12) A Constellation in the Chaos of Cancer Chromosomes Stephen J. Elledge, Brigham and Women's Hospital http://www.hhmi.org/news/constellation-chaos-cancer-chromosomes New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer. 13) Reservoir of Hidden HIV Larger than Previously Thought Robert Siliciano, The Johns Hopkins University http://www.hhmi.org/news/reservoir-hidden-hiv-larger-previously-thought HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient's body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs. 14) Getting Under the Skin of Scleroderma Harry C. Dietz, The Johns Hopkins University http://www.hhmi.org/news/getting-under-skin-scleroderma Scientists and clinicians have long puzzled over systemic sclerosis, the most common-and severe-form of the skin disease scleroderma. With no warning, a healthy 30- or 40-year-old person begins developing thick patches of skin on their body, and then more serious symptoms: trouble breathing or swallowing, digestive issues, and joint pain. Their skin and internal organs also gradually harden and there's no effective treatment. Those with the most severe forms of the disease can die from complications if their lung tissue hardens. HHMI researchers have now developed a mouse model of scleroderma. Their studies of the affected animals have uncovered some of the molecular pathways that go awry to cause the hardening, or fibrosis, associated with the disease. 15) RNAi Protects Mice from Deadly Heart Condition Christine E. Seidman, Brigham and Women's Hospital http://www.hhmi.org/news/rnai-protects-mice-deadly-heart-condition When a young athlete dies suddenly on a sports field, the cause is more often than not hypertrophic cardiomyopathy, a genetic disease that leads to malformation of the heart muscle. HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes the condition. When mice prone to hypertrophic cardiomyopathy received the inhibitor, they were protected from disease-and the associated cardiac electrical abnormalities -for months.
Part III, Program Service, line 4a - Medical Research	(D) Honors and Awards Received by HHMI Scientists (Fiscal Year 2014) 1) Schekman, Sdhof Awarded Nobel Prize in Physiology or Medicine The Nobel Assembly at the Karolinska Institute selected Randy W. Schekman, an HHMI investigator at the University of California, Berkeley, Thomas C. Sdhof, an HHMI investigator at Stanford University, and James E. Rothman of Yale University as recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells. The Nobel Assembly said the three scientists were being honored for solving the mystery of how the cell organizes its transport system. 2) Sdhof Shares Lasker Award The Albert and Mary Lasker Foundation selected HHMI investigator Thomas C. Sdhof of Stanford University and Richard H. Scheller of Genentech as recipients of the 2013 Albert Lasker Basic Medical Research Award. The Lasker Awards-considered among the most respected science prizes in the world-honor visionaries whose insight and perseverance have led to dramatic advances that will prevent disease and prolong life. Sdhof and Scheller were honored for discoveries concerning the molecular machinery and regulatory mechanism that underlie the rapid release of neurotransmitters. 3) HHMI Scientists Elected to The Royal Society HHMI investigators, Richard Axel, Stephen C. Harrison, and Joan A. Steitz, and HHMI senior international research scholar, Philippe J. Sansonetti, have been elected to foreign membership in The Royal Society in recognition of their exceptional contributions to science. Fellows and foreign members are elected for contributions to fundamental research as well as for leading scientific and technological progress in industry and research establishments. This year, 50 fellows and 10 foreign members were elected. 4) Breakthrough Prize Awarded to Richard Lifton The Breakthrough Prize in Life Sciences Foundation announced that HHMI investigator Richard P. Lifton of Yale University is among the six scientists awarded the Life Sciences Prize for excellence in research aimed at curing intractable diseases and extending human life. The Breakthrough Prizes recognize pioneering work in physics and genetics, cosmology, and neurology and mathematics. Each prize carries an award of $3 million. Lifton, who has been an HHMI investigator since 1994, uses genetic approaches to identify the genes and pathways that contribute to common human diseases, including cardiovascular, renal, and bone disease. He was honored by the foundation for the discovery of genes and biochemical mechanisms that cause hypertension. 5) Peter Walter Awarded Shaw Prize The Shaw Prize Foundation in Hong Kong announced that Peter Walter, an HHMI investigator at the University of California, San Francisco, has been awarded the Shaw Prize in Life Science & Medicine. Walter shared the $1 million award with Kazutoshi Mori of Kyoto University. The two were honored for their discovery of the unfolded protein response of the endoplasmic reticulum, a cell signaling pathway that controls organelle homeostasis and quality of protein export in eukaryotic cells. The Shaw Prize consists of three annual awards in astronomy, life science & medicine, and mathematical sciences. These international awards honor individuals who have achieved distinguished breakthroughs in academic and scientific research. The awards are dedicated to furthering societal progress, enhancing quality of life, and enriching humanity's spiritual civilization. 6) HHMI Scientists Elected to National Academy of Sciences Eight HHMI investigators and one HHMI professor were elected to the National Academy of Sciences. The National Academy of Sciences is a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. The scientists are Zhijian "James" Chen, University of Texas Southwestern Medical Center; James J. Collins, Boston University; Jason G. Cyster, University of California, San Francisco; Robert B. Darnell, The Rockefeller University; Michael R. Green, University of Massachusetts; Vamsi K. Mootha, Massachusetts General Hospital; Brenda Schulman, St. Jude Children's Research Hospital; and HHMI Professor Alanna Schepartz, Yale University. 7) Ten HHMI Investigators Elected to American Academy of Arts and Sciences Ten HHMI investigators were among 204 new fellows and 16 foreign honorary members elected to the American Academy of Arts and Sciences. Membership in the American Academy honors individuals who have made prominent contributions to society and to their disciplines, which include mathematics, physics, biological sciences, social sciences, humanities and the arts, public affairs and business. The Academy's broad-based membership gives it a unique capacity to conduct a wide range of interdisciplinary studies and public policy research. The new HHMI members are Arul M. Chinnaiyan, University of Michigan; Chris Q. Doe, University of Oregon; Nikola P. Pavletich, Memorial Sloan-Kettering Cancer Center; Stephen R. Quake, Stanford University; Bernardo L. Sabatini, Harvard Medical School; Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center; David G. Schatz, Yale School of Medicine; M. Celeste Simon, University of Pennsylvania School of Medicine; Wilfred A. van der Donk, University of Illinois Urbana-Champaign; Rachel I. Wilson, Harvard Medical School.
Part III, Program Service, line 4b - Science Education Programs	Statement 2 4b: Science Education Programs (A) Graduate Science Education and Medical Research Training (B) Precollege and Undergraduate Science Education Program (C) Educational Resources (D) Tangled Bank Studios (E) eLife - Open Access Journal HHMI's Department of Science Education emphasizes initiatives with the power to transform graduate, undergraduate, and precollege education in the sciences. HHMI is the largest private funder of science education in the United States. During the fiscal year, the Institute distributed $49 million in grants to support science education. The Institute's science education programs support ties between scientific research and teaching with the goal of increasing and enhancing student research opportunities; improving science courses, curricula, and instruction; and providing enhanced graduate and physician scientist training opportunities. Most HHMI grants are awarded through competitions with specific objectives and eligibility criteria and awards are generally made following a stringent process of peer review. HHMI's educational activities are funded through three major programs; the goals of each program and the major activities for the year are summarized below. (A) Graduate Science Education and Medical Research Training This program focuses on the development of innovative graduate education programs through grants to institutions and fellowships to students. It supports research fellowships for medical students, doctoral fellowships for students who are committed to increasing diversity among scientists, doctoral fellowships for international students pursuing the PhD at U.S. institutions, and awards research grants to physician-scientists at the outset of their careers as independent scientists. This fiscal year, HHMI selected seventy medical and veterinary students to participate in the Medical Research Fellows Program. The fellowships enable students to take a year off from professional school to conduct laboratory research. The hope is that these students will one day choose to work at the crossroads of basic research and clinical medicine. This year, HHMI received 191 fellowship applications from students representing 68 institutions. A record 10 fellows will be funded by HHMI Medical Fellows Program partner organizations this year: Citizens United for Research in Epilepsy (CURE), the Foundation Fighting Blindness (FFB), the Burroughs Wellcome Fund (BWF), the Society of Interventional Radiology Foundation (SIRF), K-RITH, and three new partners-the Parkinson's Disease Foundation (PDF), the Orthopaedic Research and Education Foundation (OREF), and the American Gastroenterological Association Institute (AGA). The program has funded more than 1,500 students since its start in 1989. HHMI selected 46 International Predoctoral Fellows in FY2014. Each fellow is an international student pursuing a PhD at a U.S. institution, and is provided up to three years of stipend and research-related support totaling $43,000 per year. The 46 new Fellows come from 24 countries and are studying at 21 different research universities. This year, 322 applications were received. HHMI announced an expansion of the Gilliam Fellowships for Advanced Study, a highly successful program for graduate students who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists. The expansion will award up to 30 Gilliam fellowships annually to students from groups traditionally underrepresented in the sciences. Each fellow will receive an annual award totaling $43,000, which includes a stipend, a training allowance, and an allowance for each fellow's institution, for up to three years. Previously, HHMI selected between five and nine Gilliam fellows per year. A total of 62 students were awarded Gilliam fellowships during the program's first ten years. (B) Precollege and Undergraduate Science Education Program Through this program, HHMI seeks to recruit and develop the future leaders of science and enhance science literacy among all students. Precollege grants support teacher training and inquiry-based student learning. Grants to colleges and universities support undergraduate student research, faculty and curriculum development, and science education outreach activities. Through the HHMI Professors Program, HHMI provides support to distinguished scientists with a commitment to teaching. In the 2014 fiscal year: HHMI selected 37 research universities to receive $60 million in grants to improve how science is taught. The initiative enables the schools to focus on significant and sustained improvement in retaining students in the science, technology, engineering and mathematics (STEM) disciplines. Each school receives a five-year grant that ranges between $1.2-$2.4 million. The finalists were selected after three rounds of peer review from among 170 applications submitted. HHMI began a partnership with the University of Maryland, Baltimore County (UMBC), the Pennsylvania State University (Penn State), and the University of North Carolina at Chapel Hill (UNC), to launch the collaborative Meyerhoff Adaptation Project. The project aims to learn whether elements of UMBC's highly regarded Meyerhoff Scholars Program can be adapted at Penn State and UNC. The participating schools hope to share what they learn so other institutions might follow. During the five-year Meyerhoff Adaptation Project, Penn State and UNC, working closely with UMBC and HHMI, will expand and study the Meyerhoff model, while applying it to newly created programs on their campuses. HHMI selected 15 new HHMI professors, accomplished research scientists who are making science more engaging for undergraduates. HHMI will make a $1 million grant over five years to each HHMI professor's university to create activities that integrate their research with student learning in ways that enhance undergraduate students' understanding of science. By providing HHMI professors with the funds and support to implement their ideas, HHMI hopes to empower these individuals to create new models for teaching science at research universities. The newly selected group-who represent 13 universities across the country-will join the community of HHMI professors who are working together to change undergraduate science education in the United States. A total of 78 college students were selected to participate in HHMI's Exceptional Research Opportunities Program (EXROP). In addition, 27 students from the 2013 EXROP program were funded to return to their 2013 labs for a second summer research experience. The EXROP program provides summer research experiences in the labs of HHMI investigators, professors, and at the Janelia Research Campus. Now in its 12th year, the EXROP program is designed to encourage the students to pursue careers in science.
Part III, Program Service, line 4b - Science Education Programs	(C) Educational Resources (continued) The Educational Resources Program produces science education resources including interactive multimedia materials, scientific animations, videos, in-class activities, the annual Holiday Lectures on Science, as well as broadcast-quality short films. The products are then made available to educators via DVD, the BioInteractive.org website, and by working collaboratively with teachers at workshops and conventions. The 2013 Holiday Lectures on Science featured HHMI investigators, Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center and Christopher A. Walsh of Boston Children's Hospital, who discussed, "Medicine in the Genomic Era." Sawyers and Walsh delivered their lectures live to an audience of nearly 200 high school students from the Washington, DC area. They discussed the breathtaking pace of discoveries into the genetic causes of various types of cancers and diseases of the nervous system, and discussed the impact of those discoveries on our understanding of normal human development and disease. Their lectures were later made available to a national and international audience through the distribution of free DVDs and the development of accompanying teaching materials. Each year, more than 100,000 copies of the DVDs are distributed; the supporting website receives more than two million visits annually. At the National Association of Biology Teachers (NABT) annual meeting, HHMI premiered three short films from The Origin of Species series. The first film, "The Making of a Theory," sets the stage by recounting the epic voyages of Charles Darwin and Alfred Wallace and how they independently conceived of the mechanism of natural selection to explain species diversity. The second film, "The Beak of the Finch," takes viewers on a journey to discover the processes by which new species form. The last film in the series, "Lizards in an Evolutionary Tree," continues to explore the processes responsible for speciation by taking viewers to the islands of the Caribbean where the Anole lizards live. At the NABT meeting, HHMI also debuted the first film in a new series called Great Discoveries in Science. The film, "The Double Helix," brings to the classroom the story of how the double-helical structure of the DNA molecule was first determined by James Watson and Francis Crick working at the Cavendish Laboratory. The film recounts the challenges, false starts, and eventual success, that lead to the seminal 1953 Nature paper. At the annual meeting of the National Science Teachers Association, HHMI premiered a new film in The Great Transitions series. "The Origin of Tetrapods" film focuses on the fish-to-tetrapod transition and the dramatic discovery of Tiktaalik by University of Chicago biologist Neil Shubin. The short science films are all available on the Biointeractive website, www.hhmi.org/biointeractive. (D) Tangled Bank Studios Tangled Bank Studios, LLC, HHMI's documentary film production unit, is dedicated to the creation of original science documentaries for broadcast, theatrical, and digital distribution. As an extension of HHMI's longstanding science education mission, the company aims to produce programs that capture compelling stories of discovery across all branches of scientific inquiry, with particular focus on the life sciences. This year, the following Tangled Bank Studios' productions were completed for broadcast on PBS: Your Inner Fish, a scientific adventure story based on the best-selling book by paleontologist and anatomist Neil Shubin, Ph.D., of the University of Chicago. It takes us from South Africa to the Arctic Circle to uncover the 3.5-billion-year history of the human body-and how our ancient ancestors have shaped our anatomy. This three-part series, produced in collaboration with U.K. production company Windfall Films, aired on PBS in April 2014. It was accompanied by a program website (pbs.org/inner fish) that included written materials, short videos, and interactive features. Vaccines - Calling the Shots encourages parents to ask questions and use the best available evidence to make decisions about how to protect their children from vaccine-preventable diseases. This documentary travels the globe to provide the latest evidence and answers. Featuring scientists, pediatricians, psychologists, anthropologists, and parents wrestling with vaccine-related questions, the hour-long film explores the history and science behind vaccinations, tracks outbreaks, and sheds light on the risks of opting out. The film, produced for NOVA by Tangled Bank Studios in association with Genepool Productions, premiered in September 2014. It was accompanied by a program website that featured detailed essays, graphics and short videos. (E) eLife - Open Access Journal HHMI, together with the Wellcome Trust and the Max Planck Society, support a top tier scientific journal called eLife. The online journal follows an open access model and is directed by practicing scientists. eLife Sciences Publications, Ltd., is an independent non-profit entity governed by a separate board of directors. eLife began publishing research articles in late 2012 and is publishing articles online on a regular basis.
PART III, Program Service, Line 4c - Support for International Science	Statement 3 4C: Support for International Science (A) Senior International Research Scholars Program (B) International Early Career Scientist Program (C) The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) (A) Senior International Research Scholars Program HHMI continues to support 13 of the world's leading basic science researchers as Senior International Research Scholar (SIRS). The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences. The SIRS awardees, selected from a group of previous HHMI international research scholars, are respected leaders in their fields. Each HHMI senior international research scholar receives a grant of $100,000 per year over five years, and presents their research at scientific meetings held at HHMI. The gatherings are intended to facilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaboration with other HHMI scientists. The senior international research scholars' participation helps strengthen the growing network of international biomedical researchers. (B) International Early Career Scientist Program HHMI also continues to support 28 International Early Career Scientists who were selected for awards in 2012. Each selected scientist will receive $650,000 over a period of five years with the goal of helping these talented individuals establish independent research programs. In this pilot program, HHMI identified scientists who are, or have the potential to become, scientific leaders. The 28 HHMI International Early Career Scientists conduct research at 22 institutions in 12 countries. Each scientist who was selected had directed his or her own laboratory for less than seven years when they applied to HHMI. The countries represented by the HHMI International Early Career scientists are Argentina, Brazil, Chile, China, Hungary, India, Italy, Poland, Portugal, South Africa, Spain, and South Korea. (C) The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) HHMI, in partnership with the University of KwaZulu-Natal (UKZN) in South Africa, has established an international research center focused on making major scientific contributions to the worldwide effort to control the devastating co-epidemic of tuberculosis (TB) and HIV. The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) is an independent non-profit association incorporated under South African law. It is placing a major emphasis on establishing a world-class research program focused on the scientific discoveries about the infecting organisms and helping to train a new generation of scientists in Africa. HHMI has committed over $70 million to K-RITH over 10 years, including support provided during its fiscal year ended August 31, 2014. UKZN is making substantial financial and in-kind commitments to K-RITH as well. The need for more research on TB and HIV is substantial. South Africa has more residents infected with HIV than any other nation in the world. In addition, it has one of the highest per capita rates of TB in the world. K-RITH formally opened its new research building in October 2012 on the campus of the Nelson R. Mandela School of Medicine in Durban. The new facility includes high-level biosafety (BSL-3) laboratories equipped for HIV and TB research. K-RITH aims to be fully established and integrated into the overall South African and global research enterprise by 2018.

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 51056K

Schedule O (Form 990 or 990-EZ) 2013

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE R
(Form 990)

Department of the Treasury
Internal Revenue Service

Related Organizations and Unrelated Partnerships

Complete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBullet

Attach to Form 990. MediumBullet

See separate instructions.
MediumBullet

Information about Schedule R (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047

2013

Open to Public Inspection

Name of the organization

HOWARD HUGHES MEDICAL INSTITUTE

Employer identification number

59-0735717

Part I

Identification of Disregarded Entities Complete if the organization answered "Yes" on Form 990, Part IV, line 33.

(a) Name, address, and EIN (if applicable) of disregarded entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Total income	(e) End-of-year assets	(f) Direct controlling entity
(1) HHMI Cayman I Company Walker Walkers House Mary Street George Town,Grand Cayman CJ	Investment	CJ	447,595	800	HHMI
(2) HHMI II LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	64,296,103	751,711,808	HHMI
(3) HHMI IV LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	714	47,890	HHMI
(4) HHMI V LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	261,465	12,018	HHMI
(5) HHMI XII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	-23	26,788	HHMI
(6) HHMI XVI LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	14,930,447	445,643,398	HHMI
(7) Sprugos Mauritius I Ltd 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	MP	50,153,919	107,234,872	HHMI
(8) Sprugos Investments II LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	-2,096,540	10,275,342	HHMI
(9) Sprugos Investments V LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	30,205,220	195,597,995	HHMI
(10) Sprugos Investments VII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	34,127,846	238,625,770	HHMI
(11) Sprugos Investments VIII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	39,350,282	252,523,496	HHMI
(12) Sprugos Investments X LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(13) Sprugos Investments XI LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	22,088,020	163,554,706	HHMI
(14) Sprugos Investments XII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	142,558	770,587	HHMI
(15) Sprugos Investments XIII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(16) Private Equity Holding LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(17) Private Equity Holding-Ahead LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	16,076	2,472,812	HHMI
(18) Private Equity Holding-Alexa LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	-5,382	20,699	HHMI
(19) Private Equity Holding-CS Capital LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	1,623,725	15,768,115	HHMI
(20) Private Equity Holding-Eurocastle LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	-327,777	3,411,089	HHMI
(21) Private Equity Holding-Favrille LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(22) Private Equity Holding-KAP LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(23) Private Equity Holding-Royce LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(24) Private Equity Holding-Storeretro LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(25) Private Equity Holding-Xenoport LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(26) HHMI FI I LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(27) Janelia Farm Holding LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	VA			HHMI
(28) Selden Island Holding LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	VA			HHMI
(29) HHMI I LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(30) HHMI III LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(31) HHMI VI LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(32) HHMI VII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	5,469,874	23,939,513	HHMI
(33) HHMI VIII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(34) HHMI IX LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(35) HHMI X LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(36) HHMI XI LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(37) HHMI XIII LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(38) HHMI XIV LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(39) HHMI XV LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(40) Sprugos Investments LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(41) Sprugos Investments III LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(42) Sprugos Investment IV LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(43) Sprugos Investment VI LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(44) Sprugos Investments IX LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(45) Sprugos-French LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(46) Private Equity Holding II LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(47) Private Equity Holding III LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(48) Relative Value Strategies LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE			HHMI
(49) PSG LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Investment	DE	2,086	0	HHMI
(50) HHMI-SA LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Research	DE	0	435,089	HHMI
(51) Tangled Bank Studios LLC 4000 Jones Bridge Road Chevy Chase,MD20815	Film Prod.	DE			HHMI
(52) Missing Link Productions LLC 4000 Jones Bridge Road Chevy Chase,MD20815 47-1329820	Film Prod.	DE			HHMI

Part II

Identification of Related Tax-Exempt Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	(g) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	Yes	No

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50135Y

Schedule R (Form 990) 2013

Page 2

Part III

Identification of Related Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Predominant income(related, unrelated, excluded from tax under sections 512-514)	(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?		(k) Percentage ownership
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity		(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No
(1) Cerberus HH Partners LP 190 Elgin Avenue George Town KY1-9005 CJ 98-1102879	Investment	CJ	HHMI	excluded	759,459	36,285,602		No			No	97.000 %
(2) GEM HLT CO-INV Fund LP 900 North Michigan Avenue Suite 14 Chicago,IL60611 26-3195475	Investment	IL	HHMI	excluded	6,399,783	0		No			No	62.000 %
(3) HHLF LP 555 5th Avenue FL 18 New York,NY10017 46-2823996	Investment	NY	HHMI	excluded	1,149,564	53,255,743		No			No	99.000 %
(4) Luminus Credit Opportunities PIE I LP 1700 Broadway 38th Floor New York,NY10019 26-1963557	Investment	NY	HHMI	excluded	0	76,867,494		No			No	99.000 %
(5) Colony Distressed Credit & Special Situa 2450 Broadway 6th FL Santa Monica,CA90404 90-1003622	Investment	CA	HHMI	excluded	27,710	22,690,853		No			No	99.000 %
(6) Solus Opportunities Fund 2 LP 410 Park Avenue 11th FL New York,NY10022 46-3541945	Investment	NY	HHMI	excluded	1,070,412	25,968,366		No			No	97.000 %

Part IV

Identification of Related Organizations Taxable as a Corporation or Trust Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets	(h) Percentage ownership	(i) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets		Yes	No
(1) HHMI Real Estate Inc 4000 Jones Bridge Road Chevy Chase,MD20815 20-3967202	Investment	DE	HHMI	C Corp	2,713,390	8,666,818	100.000 %	Yes
(2) Pleasant Valley Investments LP 80 Raffles Place 35-41UOB Plaza 1 Singapore 048624 SN 98-0586696	Investment	CJ	HHMI	For. LP/US Corp	15,751,204	39,655,577	51.000 %	Yes
(3) HH Ellington Fund LTD Walker House 87 Mary Street Georgetown,GrKY1-9005 CJ 99-9999999	Investment	CJ	HHMI	For. LP/US Corp	33,461,247	217,357,545	100.000 %	Yes

Schedule R (Form 990) 2013

Page 3

Part V

Transactions With Related Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.

Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.

Yes

1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?

a Receipt of (i) interest (ii) annuities (iii) royalties or (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .

b Gift, grant, or capital contribution to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

c Gift, grant, or capital contribution from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

d Loans or loan guarantees to or for related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

e Loans or loan guarantees by related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

f Dividends from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

g Sale of assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

h Purchase of assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

i Exchange of assets with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

j Lease of facilities, equipment, or other assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .

k Lease of facilities, equipment, or other assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .

l Performance of services or membership or fundraising solicitations for related organization(s) . . . . . . . . . . . . . . . . . . . .

m Performance of services or membership or fundraising solicitations by related organization(s) . . . . . . . . . . . . . . . . . . . .

n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) . . . . . . . . . . . . . . . . . . . . .

o Sharing of paid employees with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

p Reimbursement paid to related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

q Reimbursement paid by related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

r Other transfer of cash or property to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

s Other transfer of cash or property from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.

(a) Name of related organization	(b) Transaction type (a-s)	(c) Amount involved
(1) Cerberus HH Partners LP	b	35,763,285
(2) Colony Distressed Credit & Special Situations	b	23,261,409
(3) HH Ellington Fund LTD	b	50,000,015
(4) HHLF LP	b	52,500,000
(5) Solus Opportunities Fund 2 LP	b	25,000,000
(6) GEM HLT Co-inv Fund LP	s	27,443,750
(7) HH Ellington Fund LTD	s	50,000,000
(8) Luminus Credit Opportunities PIE I LP	s	1,522,608

Schedule R (Form 990) 2013

Page 4

Part VI

Unrelated Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 37.

Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.

(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(e) Are all partners section 501(c)(3) organizations?		(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V?UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?
(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	Yes	No	(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V?UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No

Schedule R (Form 990) 2013

Page 5

Part VII

Supplemental Information

Provide additional information for responses to questions on Schedule R (see instructions).

Return Reference	Explanation

Schedule R (Form 990) 2013

Additional Data

Software ID:
Software Version:

1	Briefly describe the organization’s mission or most significant activities: The Howard Hughes Medical Institute is a philanthropy that serves society through the direct conduct of biomedical research and support for programs in science education.
2	Check this box
3	Number of voting members of the governing body (Part VI, line 1a) ........	3	11
4	Number of independent voting members of the governing body (Part VI, line 1b) .....	4	9
5	Total number of individuals employed in calendar year 2013 (Part V, line 2a) ......	5	3,578
6	Total number of volunteers (estimate if necessary) .............	6
7a	Total unrelated business revenue from Part VIII, column (C), line 12 ........	7a	11,359,812
b	Net unrelated business taxable income from Form 990-T, line 34 .........	7b	0

		Prior Year	Current Year
8	Contributions and grants (Part VIII, line 1h) .........	0	0
9	Program service revenue (Part VIII, line 2g) .........	1,390,495	1,842,587
10	Investment income (Part VIII, column (A), lines 3, 4, and 7d ) ....	1,335,207,844	1,988,395,214
11	Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e)	16,348,249	13,267,211
12	Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)...................	1,352,946,588	2,003,505,012
13	Grants and similar amounts paid (Part IX, column (A), lines 1–3 )...	59,924,253	111,601,663
14	Benefits paid to or for members (Part IX, column (A), line 4).....	0	0
15	Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10)	413,980,074	466,476,887
16a	Professional fundraising fees (Part IX, column (A), line 11e).....	0	0
b	Total fundraising expenses (Part IX, column (D), line 25) 0
17	Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e)....	580,081,636	584,987,394
18	Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25)	1,053,985,963	1,163,065,944
19	Revenue less expenses. Subtract line 18 from line 12.......	298,960,625	840,439,068
		Beginning of Current Year	End of Year
20	Total assets (Part X, line 16).............	19,677,721,527	21,860,329,641
21	Total liabilities (Part X, line 26).............	2,776,715,050	3,266,722,975
22	Net assets or fund balances. Subtract line 21 from line 20.....	16,901,006,477	18,593,606,666

Sign Here

	Signature of officer	Date

	Type or print name and title


4a	(Code: ) (Expenses $ 790,831,887 including grants of $ ) (Revenue $ 1,842,587 )
	Statement 1 on Schedule O Medical Research Organization Activities (A) The HHMI Investigator Program (B) Janelia Research Campus

4b	(Code: ) (Expenses $ 120,934,334 including grants of $ 104,568,559 ) (Revenue $ )
	Statement 2 On Schedule O Science Education Programs (A) Graduate Science Education and Medical Research Training (B) Precollege and Undergraduate Science Education Program (C) Educational Resources (D) Tangled Bank Studios (E) eLife - Open Access Journal

4c	(Code: ) (Expenses $ 7,033,104 including grants of $ 7,033,104 ) (Revenue $ )
	Statement 3 On Schedule O Support for International Science (A)International Early Career Scientist Program (B)Senior International Research Scholars Program (C)The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH)

4d	Other program services (Describe in Schedule O.)
	(Expenses $ including grants of $ ) (Revenue $ )
4e	Total program service expenses918,799,325

1b	Sub-Total................
c	Total from continuation sheets to Part VII, Section A....
d	Total (add lines 1b and 1c)............	19,333,517	0	1,183,334

				(A) Total revenue	(B) Related or exempt function revenue	(C) Unrelated business revenue	(D) Revenue excluded from tax under sections 512-514
1a	Federated campaigns..1a
b	Membership dues....1b
c	Fundraising events....1c
d	Related organizations...1d
e	Government grants (contributions)1e

f	All other contributions, gifts, grants, and similar amounts not included above1f

g	Noncash contributions included in lines 1a-1f:$
h	Total. Add lines 1a-1f.......			0
			Business Code
2a	RENTAL INCOME		900099	1,605,673	1,605,673
b	TV & FILM ROYALTIES		900099	236,914	236,914
c
d
e
f	All other program service revenue .
g	Total. Add lines 2a–2f........			1,842,587
3	Investment income (including dividends, interest, and other similar amounts).......			275,747,695		3,912,683	271,835,012
4	Income from investment of tax-exempt bond proceeds..			13,453			13,453
5	Royalties...........			11,887,336			11,887,336
		(i) Real	(ii) Personal
6a	Gross rents	1,518,907
b	Less: rental expenses	1,147,234
c	Rental income or (loss)	371,673	0
d	Net rental income or (loss).......			371,673		317,031	54,642
		(i) Securities	(ii) Other
7a	Gross amount from sales of assets other than inventory	54,122,589,880	7,130,098
b	Less: cost or other basis and sales expenses	52,416,745,689
c	Gain or (loss)	1,705,844,191	7,130,098
d	Net gain or (loss)..........			1,712,634,066		7,130,098	1,705,503,968
8a	Gross income from fundraising events (not including $ of contributions reported on line 1c). See Part IV, line 18 ..
	a
b	Less: direct expenses ...b
c	Net income or (loss) from fundraising events..			0
9a	Gross income from gaming activities. See Part IV, line 19 ...
	a
b	Less: direct expenses ...b
c	Net income or (loss) from gaming activities...			0
10a	Gross sales of inventory, less returns and allowances .
	a
b	Less: cost of goods sold ..b
c	Net income or (loss) from sales of inventory..			0
Miscellaneous Revenue			Business Code
11a	CAFETERIA INCOME		900099	190,360			190,360
b	INVESTMENT EXPENSE REBATE		900099	194,427			194,427
c	CASH DISCOUNTS		900099	121,490			121,490
d	All other revenue ....			501,925			501,925
e	Total. Add lines 11a–11d ......			1,008,202
12	Total revenue. See Instructions......			2,003,505,012	1,842,587	11,359,812	1,990,302,613


				(A) Beginning of year		(B) End of year
1	Cash–non-interest-bearing .............			0	1	0
2	Savings and temporary cash investments .........			374,609,412	2	305,401,048
3	Pledges and grants receivable, net ...........			0	3	0
4	Accounts receivable, net .............			0	4	0
5	Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of Schedule L ..................
				0	5	0
6	Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
				0	6	0
7	Notes and loans receivable, net .............			0	7	0
8	Inventories for sale or use ..............			0	8	0
9	Prepaid expenses and deferred charges ..........			7,388,741	9	8,948,454
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	1,848,686,635
b	Less: accumulated depreciation .....	10b	1,052,706,954	814,431,783	10c	795,979,681
11	Investments—publicly traded securities ..........			7,407,499,312	11	8,046,600,998
12	Investments—other securities. See Part IV, line 11 .....			10,892,032,785	12	12,571,418,897
13	Investments—program-related. See Part IV, line 11 .....			0	13	0
14	Intangible assets ...............			0	14	0
15	Other assets. See Part IV, line 11 ...........			181,759,494	15	131,980,563
16	Total assets. Add lines 1 through 15 (must equal line 34)......			19,677,721,527	16	21,860,329,641
17	Accounts payable and accrued expenses .........			387,750,043	17	469,629,746
18	Grants payable .................			106,249,684	18	148,458,340
19	Deferred revenue ................			0	19	0
20	Tax-exempt bond liabilities .............			716,130,000	20	716,130,000
21	Escrow or custodial account liability. Complete Part IV of Schedule D..			0	21	0
22	Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
	persons. Complete Part II of Schedule L..........			0	22	0
23	Secured mortgages and notes payable to unrelated third parties ..			0	23	0
24	Unsecured notes and loans payable to unrelated third parties ....			1,237,912,529	24	1,238,158,876
25	Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D....................			328,672,794	25	694,346,013
26	Total liabilities. Add lines 17 through 25.........			2,776,715,050	26	3,266,722,975
	Organizations that follow SFAS 117 (ASC 958), check here and complete lines 27 through 29, and lines 33 and 34.
27	Unrestricted net assets ..............			16,901,006,477	27	18,593,606,666
28	Temporarily restricted net assets ...........			0	28	0
29	Permanently restricted net assets ...........			0	29	0
	Organizations that do not follow SFAS 117 (ASC 958), check here and complete lines 30 through 34.
30	Capital stock or trust principal, or current funds ........				30
31	Paid-in or capital surplus, or land, building or equipment fund .....				31
32	Retained earnings, endowment, accumulated income, or other funds				32
33	Total net assets or fund balances ...........			16,901,006,477	33	18,593,606,666
34	Total liabilities and net assets/fund balances ........			19,677,721,527	34	21,860,329,641

1	Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes,"the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926)......................................	Yes	No
2	Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A).......................................	Yes	No
3	Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471)..............................	Yes	No
4	Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621)...............................................	Yes	No
5	Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships. (see Instructions for Form 8865)....................................	Yes	No
6	Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see Instructions for Form 5713)................................................	Yes	No