Form990
Click to see attachment
Department of the Treasury
Internal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)
MediumBullet Do not enter Social Security numbers on this form as it may be made public. By law, the IRS
generally cannot redact the information on the form.
MediumBullet Information about Form 990 and its instructions is at www.IRS.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
A For the 2013 calendar year, or tax year beginning 12-01-2013 , 2013, and ending 11-30-2014
BCheck if applicable:
CName of organization
VAN ANDEL RESEARCH INSTITUTE
 
Doing Business As
 
 
Number and street (or P.O. box if mail is not delivered to street address)
333 BOSTWICK AVENUE NE
 
Room/suite
City or town, state or province, country, and ZIP or foreign postal code
GRAND RAPIDS, MI49503
D Employer identification number

52-2000823
E Telephone number

G Gross receipts $ 76,553,584
F Name and address of principal officer:
TIMOTHY J MYERS
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI49503
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.VAI.ORG
H(a)
Is this a group return for
subordinates?
H(b)
Are all subordinates
included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:
 
L Year of formation: 1996
M State of legal domicile: MI
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: MEDICAL RESEARCH ORGANIZATION
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 5
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 3
5 Total number of individuals employed in calendar year 2013 (Part V, line 2a) ...... 5 402
6 Total number of volunteers (estimate if necessary) ............. 6 0
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 646,113
b Net unrelated business taxable income from Form 990-T, line 34 ......... 7b 158,398
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 54,068,694 67,009,142
9 Program service revenue (Part VIII, line 2g) ......... 693,011 1,460,533
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 64,454 260,434
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 7,773,170 6,325,873
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)................... 62,599,329 75,055,982
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 302,224 201,907
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 28,311,621 29,232,885
16a Professional fundraising fees (Part IX, column (A), line 11e)..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet1,314,444    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 39,419,946 37,139,975
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 68,033,791 66,574,767
19 Revenue less expenses. Subtract line 18 from line 12....... -5,434,462 8,481,215
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 224,789,773 251,725,432
21 Total liabilities (Part X, line 26)............. 290,456,167 327,697,622
22 Net assets or fund balances. Subtract line 21 from line 20..... -65,666,394 -75,972,190
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
Preparer's signature
Date
PTIN
Firm's name MediumBullet

Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ............
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y
Form 990 (2013)
Form 990 (2013)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III ..............
1
Briefly describe the organization’s mission: MEDICAL RESEARCH ORGANIZATION VAN ANDEL RESEARCH INSTITUTE IS AN INDEPENDENT BIOMEDICAL RESEARCH ORGANIZATION COMMITTED TO IMPROVING THE HEALTH AND ENHANCING THE LIVES OF CURRENT AND FUTURE GENERATIONS.
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ......................
If "Yes," describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program services? ............................
If "Yes," describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 9,445,653 including grants of $ 162,442 ) (Revenue $ 998,737 )
CENTER FOR CANCER AND CELL BIOLOGY SCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS.
4b (Code:   ) (Expenses $ 3,648,152 including grants of $ 39,465 ) (Revenue $ 54,077 )
CENTER FOR EPIGENETICSSCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS.
4c (Code:   ) (Expenses $ 3,523,348 including grants of $   ) (Revenue $   )
CENTER FOR NEURODEGENERATIVE SCIENCESEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM'S ACCOMPLISHMENTS.
(Code:   ) (Expenses $ 27,399,460 including grants of $   ) (Revenue $ 407,719 )
4d Other program services (Describe in Schedule O.)
(Expenses $ 27,399,460 including grants of $   ) (Revenue $ 407,719 )
4e Total program service expensesMediumBullet44,016,613
Form 990 (2013)
Form 990 (2013)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule AClick to see attachment........................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? Click to see attachment...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part IClick to see attachment..........
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part IIClick to see attachment........
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If "Yes," complete Schedule C,
Part IIIClick to see attachment............................
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part IClick to see attachment........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part IIClick to see attachment...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes," complete Schedule D, Part III Click to see attachment....................
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IVClick to see attachment..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments? If "Yes," complete Schedule D, Part VClick to see attachment......
10
 
No
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10?
If "Yes," complete Schedule D, Part VI.Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIClick to see attachment.......
11b
 
No
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIIClick to see attachment.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IXClick to see attachment............
11d
Yes
 
e
Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part XClick to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part XClick to see attachment.........................
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year?
If "Yes," complete Schedule D, Parts XI and XII Click to see attachment.................
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E....
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States?.....
14a
Yes
 
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV......... Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IVClick to see attachment
15
 
No
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV... Click to see attachment
16
 
No
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I (see instructions)....
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....
20a
 
No
b
If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
Form 990 (2013)
Form 990 (2013)
Page 4
Part IV
Checklist of Required Schedules (continued)
21
Did the organization report more than $5,000 of grants or other assistance to any domestic organization or government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II... Click to see attachment
21
 
No
22
Did the organization report more than $5,000 of grants or other assistance to individuals in the United States on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........ Click to see attachment
22
Yes
 
23
Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a................ Click to see attachment
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds?......................
24c
 
No
d
Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3) and 501(c)(4) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I........ Click to see attachment
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I................... Click to see attachment
25b
 
No
26
Did the organization report any amount on Part X, line 5, 6, or 22 for receivables from or payables to any current or former officers, directors, trustees, key employees, highest compensated employees, or disqualified persons? If so, complete Schedule L, Part II.................... Click to see attachment
26
Yes
 
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part III......... Click to see attachment
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If "Yes," complete Schedule L, Part IV .......................... Click to see attachment
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If "Yes,"
complete Schedule L, Part IV..................... Click to see attachment
28b
 
No
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or direct or indirect owner? If "Yes," complete Schedule L, Part IV... Click to see attachment
28c
Yes
 
29
Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M..Click to see attachment
29
Yes
 
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M............. Click to see attachment
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N,
Part I...........................
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II......................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I........ Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1........................ Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2... Click to see attachment
35b
Yes
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2............. Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2013)
Form 990 (2013)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V ..............
Yes
No
1a
Enter the number reported in Box 3 of Form 1096 Enter -0- if not applicable ..
1a
119
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
 
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
402
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)?..........................
4a
 
No
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for Form TD F 90-22.1, Report of Foreign Bank and Financial Accounts.
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year?..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions?...
6a
 
No
b
If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible?........................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor?....................
7a
 
No
b
If "Yes," did the organization notify the donor of the value of the goods or services provided?.....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282?...........................
7c
 
No
d
If "Yes," indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?............................
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract?..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?............................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C?..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds and section 509(a)(3) supporting organizations. Did the supporting organization, or a donor advised fund maintained by a sponsoring organization, have excess business holdings at any time during the year?............
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the organization make any taxable distributions under section 4966?..........
9a
 
 
b
Did the organization make a distribution to a donor, donor advisor, or related person?.......
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If "Yes," enter the amount of tax-exempt interest received or accrued during the year. ....................
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..
14b
 
 
Form 990 (2013)
Form 990 (2013)
Page 6
Part VI
Governance, Management, and Disclosure For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI ..............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year .....................
1a
5
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent ...................
1b
3
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
Yes
 
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? ...........................
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
Yes
 
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .........................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If "No," go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe in Schedule O how this was done.......................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
MI
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, physical address, and telephone number of the person who possesses the books and records of the organization:
MediumBulletTIMOTHY J MYERS CFO333 BOSTWICK AVENUE NEGRAND RAPIDSMI495032518 (616) 234-5368
Form 990 (2013)
Form 990 (2013)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII ..............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(1) DAVID VAN ANDEL........................................................................
CHAIRMAN / CEO
 36.00
.......................17.00 		X   X       416,751 0 133,745
(2) DR GEORGE VANDE WOUDE........................................................................
TRUSTEE/ INVESTIGATOR
 50.00
.......................0.00 		X           300,227 0 26,792
(3) DR JAMES FAHNER........................................................................
TRUSTEE
 1.00
.......................1.00 		X           10,000 2,000 0
(4) DR GARY TARPLEY........................................................................
TRUSTEE
 1.00
.......................0.00 		X           10,000 0 0
(5) DR RALPH WEICHSELBAUM........................................................................
TRUSTEE
 1.00
.......................0.00 		X           4,500 0 0
(6) TIMOTHY MYERS........................................................................
V.P. & CHIEF FINANCIAL OFFICER
 50.00
.......................3.00 		    X       235,524 0 79,088
(7) DAVID WHITESCARVER........................................................................
SECRETARY/V.P. & CHIEF LEGAL OFFICER
 50.00
.......................3.00 		    X       356,220 0 128,674
(8) DR JANA HALL........................................................................
CHIEF OPERATIONS OFFICER
 50.00
.......................3.00 		    X       316,987 0 99,279
(9) DR H ERIC XU........................................................................
INVESTIGATOR
 45.00
.......................0.00 		        X   296,596 0 53,125
(10) DR SCOTT JEWELL........................................................................
INVESTIGATOR
 45.00
.......................0.00 		        X   317,294 0 66,139
(11) LOVE COLLINS III........................................................................
V.P. OF DEVELOPMENT, COMM. & MKTNG.
 45.00
.......................0.00 		        X   292,750 0 89,544
(12) DR PATRIK BRUNDIN........................................................................
VARI ASSOCIATE DIRECTOR OF RESEARCH
 45.00
.......................0.00 		        X   475,233 0 112,798
(13) GERALD CALLAHAN........................................................................
V.P. OF BUSINESS DEVELOPMENT
 45.00
.......................0.00 		        X   231,554 0 85,150
(14) R JACK FRICK DONE 121111........................................................................
CHIEF ADMINISTRATIVE OFFICER -FORMER
 0.00
.......................0.00 		          X 187,705 0 0






Form 990 (2013)
Form 990 (2013)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;


























1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)............MediumBullet 3,451,341 2,000 874,334
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organizationMediumBullet44
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............
3
Yes
 
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
DK SECURITY INC5160 FALCONVIEW AVE SEKENTWOODMI49512 SECURITY SERVICES 384,716
HONIGMAN MILLER SCHWARTZ LLC130 SOUTH FIRST ST 4TH FLANN ARBORMI482263506 LEGAL/ CONSULTING 271,701
FEDERAL EXPRESSPO BOX 223125PITTSBURGHPA152512125 SHIPPING 227,088
OLYMPIA ENTERTAINMENT INC2211 WOODWARD AVE 5THDETROITMI48201 ADVERTISING 225,300
FAIRLY PAINLESS ADVERTISING44 EAST EIGHTH STREETHOLLANDMI49423 ADVERTISING 218,702
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet19
Form 990 (2013)
Form 990 (2013)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII .............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512-514
Contributions, Gifts, GrantAmt and OtherAmt Similar Amounts 1a Federated campaigns..1a  
b Membership dues....1b  
c Fundraising events....1c  
d Related organizations...1d 54,244,758
e Government grants (contributions)1e 8,081,101
f All other contributions, gifts, grants, and
similar amounts not included above1f 		4,683,283
g Noncash contributions included in lines
1a-1f:$ 		152,911
h Total. Add lines 1a-1f.......MediumBullet 67,009,142
Program Service RevenueAmt Business Code
2a RESEARCH BILLED REV 541700 1,460,533 851,139 609,394  
b
c
d
e
f All other program service revenue .        
g Total. Add lines 2a–2f........MediumBullet 1,460,533
OtherAmt RevenueAmt 3 Investment income (including dividends, interest, and other similar amounts).......MediumBullet 255,626     255,626
4 Income from investment of tax-exempt bond proceeds..MediumBullet        
5 Royalties...........MediumBullet 491,283     491,283
(i) Real (ii) Personal
6a Gross rents 1,487,416  
b Less: rental expenses 1,468,592  
c Rental income or (loss) 18,824  
d Net rental income or (loss).......MediumBullet 18,824 18,824    
(i) Securities (ii) Other
7a Gross amount from sales of assets other than inventory   33,818
b Less: cost or other basis and sales expenses   29,010
c Gain or (loss)   4,808
d Net gain or (loss)..........MediumBullet 4,808 4,808    
8a Gross income from fundraising events (not including
$  
of contributions reported on line 1c). See Part IV, line 18 ..
a  
b Less: direct expenses ...b  
c Net income or (loss) from fundraising events..MediumBullet      
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities...MediumBullet        
10a Gross sales of inventory, less
returns and allowances .
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet        
Miscellaneous Revenue Business Code
11a REL. PARTY ADMIN SUPPO 561000 5,401,058     5,401,058
b REIMBURSED EXPENSES 900099 271,487     271,487
c STATE TAX REFUNDS 900099 36,719   36,719  
d All other revenue .... 106,502     106,502
e Total. Add lines 11a–11d ...... MediumBullet 5,815,766
12 Total revenue. See Instructions......MediumBullet 75,055,982 874,771 646,113 6,525,956
Form 990 (2013)
Form 990 (2013)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX ...............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to governments and organizations in the United States. See Part IV, line 21    
2 Grants and other assistance to individuals in the United States. See Part IV, line 22 201,907 201,907
3 Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16    
4 Benefits paid to or for members    
5 Compensation of current officers, directors, trustees, and key employees .... 2,384,297 769,206 1,615,091  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) ....        
7 Other salaries and wages 21,012,535 11,883,978 8,420,804 707,753
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 1,716,490 1,035,265 628,557 52,668
9 Other employee benefits ....... 2,903,422 1,751,315 1,061,301 90,806
10 Payroll taxes ........... 1,216,141 733,574 444,428 38,139
11 Fees for services (non-employees):        
a Management ......        
b Legal ......... 407,217 63,881 343,336  
c Accounting ........... 105,100   105,100  
d Lobbying ........... 262,848   262,848  
e Professional fundraising services. See Part IV, line 17    
f Investment management fees ......        
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) ........ 2,711,964 2,024,936 558,301 128,727
12 Advertising and promotion .... 1,226,668 4,637 1,079,977 142,054
13 Office expenses ....... 99,650 49,654 49,689 307
14 Information technology ...... 361,357 142,065 203,435 15,857
15 Royalties ..        
16 Occupancy ........... 2,511,541 2,235,158 274,077 2,306
17 Travel ............ 875,355 436,370 387,963 51,022
18 Payments of travel or entertainment expenses for any federal, state, or local public officials ......        
19 Conferences, conventions, and meetings .... 195,902 133,428 59,489 2,985
20 Interest ........... 8,633,669 7,182,829 1,450,840  
21 Payments to affiliates .......        
22 Depreciation, depletion, and amortization ..... 9,128,908 7,880,962 1,247,946  
23 Insurance .............. 438,396 268,277 170,119  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a LAB SUPPLIES & SERVICES 3,223,883 3,214,501 9,382  
b EQUIPMENT & SOFTWARE 2,607,673 1,276,892 1,312,073 18,708
c OTHER SCIENTIFIC 1,303,572 1,295,845 7,727  
d BAD DEBT EXPENSE 523,400   523,400  
e All other expenses 2,522,872 1,431,933 1,027,827 63,112
25 Total functional expenses. Add lines 1 through 24e 66,574,767 44,016,613 21,243,710 1,314,444
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2013)
Form 990 (2013)
Page 11
Part X Balance Sheet Check if Schedule O contains a response or note to any line in this Part X ..............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash–non-interest-bearing .............   1  
2 Savings and temporary cash investments ......... 487,783 2 12,177,780
3 Pledges and grants receivable, net ........... 2,496,299 3 2,575,159
4 Accounts receivable, net ............. 1,841,254 4 2,523,497
5 Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of
Schedule L ..................
18,355 5 9,657
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
  6  
7 Notes and loans receivable, net ............. 1,596,595 7 1,555,278
8 Inventories for sale or use ..............   8  
9 Prepaid expenses and deferred charges .......... 1,127,550 9 1,522,498
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 269,164,333
b Less: accumulated depreciation ..... 10b 75,691,793 197,287,670 10c 193,472,540
11 Investments—publicly traded securities ..........   11  
12 Investments—other securities. See Part IV, line 11 ..... 943,113 12 1,268,817
13 Investments—program-related. See Part IV, line 11 .....   13  
14 Intangible assets ...............   14  
15 Other assets. See Part IV, line 11 ........... 18,991,154 15 36,620,206
16 Total assets. Add lines 1 through 15 (must equal line 34)...... 224,789,773 16 251,725,432
Liabilities 17 Accounts payable and accrued expenses ......... 26,805,514 17 44,640,472
18 Grants payable .................   18  
19 Deferred revenue ................ 474,750 19 2,206,247
20 Tax-exempt bond liabilities ............. 220,000,000 20 220,000,000
21 Escrow or custodial account liability. Complete Part IV of Schedule D..   21  
22 Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L..........   22  
23 Secured mortgages and notes payable to unrelated third parties ..   23  
24 Unsecured notes and loans payable to unrelated third parties ....   24  
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D.................... 43,175,903 25 60,850,903
26 Total liabilities. Add lines 17 through 25......... 290,456,167 26 327,697,622
Net Assets or Fund Balance Organizations that follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets .............. -66,813,709 27 -78,281,142
28 Temporarily restricted net assets ........... 1,143,715 28 2,215,852
29 Permanently restricted net assets ........... 3,600 29 93,100
Organizations that do not follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds ........   30  
31 Paid-in or capital surplus, or land, building or equipment fund .....   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ........... -65,666,394 33 -75,972,190
34 Total liabilities and net assets/fund balances ........ 224,789,773 34 251,725,432
Form 990 (2013)
Form 990 (2013)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI ..............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
75,055,982
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
66,574,767
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
8,481,215
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) ..
4
-65,666,394
5
Net unrealized gains (losses) on investments ...............
5
34,742
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
-18,821,753
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 33, column (B))
10
-75,972,190
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII .............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
Yes
 
b
If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.
3b
Yes
 
Form 990 (2013)
Form 990, Special Condition Description:
Special Condition Description
Additional Data


Software ID:  
Software Version:  
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ. right arrow See separate instructions.
right arrow Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4
SPECTRUM HEALTH,
  ,
GRAND RAPIDS, MI  
TRINITY HEALTH,
  ,
GRAND RAPIDS, MI  
5
section 170(b)(1)(A)(iv). (Complete Part II.)
6
7
8
9
receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 331/3% of
its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses
acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)
10
11
e
f
g
(i) A person who directly or indirectly controls, either alone or together with persons described in (ii)
Yes
No
and (iii) below, the governing body of the supported organization? ................
11g(i)
 
 
(ii) A family member of a person described in (i) above? ......................
11g(ii)
 
 
(iii) A 35% controlled entity of a person described in (i) or (ii) above? ................
11g(iii)
 
 
h
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) (iv) Is the organization in col. (i) listed in your governing document? (v) Did you notify the organization in col. (i) of your support? (vi) Is the organization in col. (i) organized in the U.S.? (vii) Amount of monetary support
Yes No Yes No Yes No
Total  

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) 2013 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") ....            
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3            
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..  
6 Public support. Subtract line 5 from line 4.  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) 2013 (f) Total
7 Amounts from line 4..            
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...            
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.)..            
11 Total support (Add lines 7 through 10).  
12
12
 
13
First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a 501(c)(3) organization, check this box and stop here.................................................right arrow
Section C. Computation of Public Support Percentage
14
14
 
15
15
 
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) 2013 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513..            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support (Subtract line 7c from line 6.)  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2009 (b) 2010 (c) 2011 (d) 2012 (e) 2013 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part IV.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2013
Schedule A (Form 990 or 990-EZ) 2013
Page 4
Part IV
Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; and Part III, line 12. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Explanation
 
 
 
 
Schedule A (Form 990 or 990-EZ) 2013

Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors
Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
Arrow Bullet Information about Schedule B (Form 990, 990-EZ, or 990-PF) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ





Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note. Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......................... Arrow Bullet $  
Caution. An organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its
Form 990-EZ or on its Form 990PF, Part I, line 2, to certify that it does not meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2013)

Schedule B (Form 990, 990-EZ, or 990-PF) (2013)
Page 2
Name of organization
VAN ANDEL RESEARCH INSTITUTE
  		Employer identification number

52-2000823
Part I
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
RESTRICTED
 

   
RESTRICTED
RESTRICTED
RESTRICTED, RESTRICTEDRESTRICTED

$RESTRICTED


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2013)

Schedule B (Form 990, 990-EZ, or 990-PF) (2013)
Page 3
Name of organization
VAN ANDEL RESEARCH INSTITUTE
  		Employer identification number

52-2000823
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a) No.
from
Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2013)

Schedule B (Form 990, 990-EZ, or 990-PF) (2013)
Page 4
Name of organization
VAN ANDEL RESEARCH INSTITUTE
  		Employer identification number

52-2000823
Part III
Exclusively religious, charitable, etc., individual contributions to section 501(c)(7), (8), or (10) organizations
that total more than $1,000 for the year. Complete columns (a) through (e) and the following line entry.
For organizations completing Part III, enter the total of exclusively religious, charitable, etc.,
contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a) No.
from
Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2013)

Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet Complete if the organization is described below.SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd Bullet See separate instructions.SchCMd Bullet Information about Schedule C (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public
Inspection
If the organization answered "Yes" to Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" to Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" to Form 990, Part IV, Line 5 (Proxy Tax) or Form 990-EZ, Part V, line 35c (Proxy Tax), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV.
2
Political expenditures ....................................SchCMd Bullet
$  
3
Volunteer hours ........................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 .........SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 ......SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ..............
4a
Was a correction made? .........................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ...................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b..SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ..........................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.










For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2013

Schedule C (Form 990 or 990-EZ) 2013
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
organization's
totals 		(b) Affiliated group
totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......    
b Total lobbying expenditures to influence a legislative body (direct lobbying) ....... 367,563  
c Total lobbying expenditures (add lines 1a and 1b) ................... 367,563  
d Other exempt purpose expenditures ........................ 66,207,204  
e Total exempt purpose expenditures (add lines 1c and 1d) ............... 66,574,767  
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		 1,000,000  
If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
Not over $500,00020% of the amount on line 1e.
Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
Over $17,000,000$1,000,000.
g Grassroots nontaxable amount (enter 25% of line 1f) ................. 250,000  
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................ 0  
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................ 0  
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ......................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the instructions for lines 2a through 2f on page 4.)
Lobbying Expenditures During 4-Year Averaging Period
Calendar year (or fiscal year
beginning in) 		(a) 2010 (b) 2011 (c) 2012 (d) 2013 (e) Total
2a Lobbying nontaxable amount   1,000,000 1,000,000 1,000,000 3,000,000
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		4,500,000
c Total lobbying expenditures   68,133 85,680 367,563 521,376
d Grassroots nontaxable amount   250,000 250,000 250,000 750,000
e Grassroots ceiling amount
(150% of line 2d, column (e))		 1,125,000
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2013


Schedule C (Form 990 or 990-EZ) 2013
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each "Yes" response to lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
No
Yes
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? .........................................
 
 
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ....
 
 
c
Media advertisements? ....................................
 
 
 
d
Mailings to members, legislators, or the public? .........................
 
 
 
e
Publications, or published or broadcast statements? .......................
 
 
 
f
Grants to other organizations for lobbying purposes? .......................
 
 
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? ........
 
 
 
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ......
 
 
 
i
Other activities? ..........................
 
 
 
j
Total. Add lines 1c through 1i ...............................
 
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
 
b
If "Yes," enter the amount of any tax incurred under section 4912 .................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 .....
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? .......
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? ..........
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members .....................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).
a
Current year .........................................
2a
 
b
Carryover from last year ....................................
2b
 
c
Total ............................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) ..............
5
 
Part IV
Supplemental Information
Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, line 2; and Part ll-B, line 1. Also, complete this part for any additional information.
Return Reference Explanation
Schedule C (Form 990 or 990EZ) 2013

Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," to Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b
SchDMd Bullet Attach to Form 990. SchDMd Bullet See separate instructions. SchDMd Bullet Information about Schedule D (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" to Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate contributions to (during year) ...    
3 Aggregate grants from (during year) .....    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements. Complete if the organization answered "Yes" to Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ....................... 2a  
b Total acreage restricted by conservation easements .................. 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register .................... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during
the tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and
enforcement of the conservation easements it holds? .............................
6
Staff and volunteer hours devoted to monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .......................................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" to Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenues included in Form 990, Part VIII, line 1 ........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ..............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958) relating to these items:
a
Revenues included in Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2013

Schedule D (Form 990) 2013
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?........
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" to Form 990,
Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b
If "Yes," explain the arrangement in Part XIII and complete the following table:
Amount
c Beginning balance ................................. 1c  
d Additions during the year .............................. 1d  
e Distributions during the year ............................. 1e  
f Ending balance ................................... 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21? .....................
b
If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ........
Part V
Endowment Funds. Complete if the organization answered "Yes" to Form 990, Part IV, line 10.
(a)Current year (b)Prior year b (c)Two years back (d)Three years back (e)Four years back
1a Beginning of year balance ....          
b Contributions ........          
c Net investment earnings, gains, and losses          
d Grants or scholarships .....          
e Other expenditures for facilities
and programs ........ 		         
f Administrative expenses ....          
g End of year balance ......          
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Temporarily restricted endowment SchDMd Bullet  
The percentages in lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations ........................
3a(i)
 
 
(ii) related organizations ........................
3a(ii)
 
 
b
If "Yes" to 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis (investment) (b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .................   5,288,315 5,288,315
b Buildings ................   219,768,174 43,371,435 176,396,739
c Leasehold improvements ............        
d Equipment ................   41,304,971 32,310,457 8,994,514
e Other .................   2,802,873 9,901 2,792,972
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).).......SchDMdBullet 193,472,540
Schedule D (Form 990) 2013

Schedule D (Form 990) 2013
Page 3
Part VII
Investments—Other Securities. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c) Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
Other








Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet  
Part VIII
Investments—Program Related. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation:
Cost or end-of-year market value








Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(1) BOND ISSUANCE COSTS NET OF ACCUMULATED AMORTIZATION 310,206
(2) PLEDGED SECURITIES 36,310,000







Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet 36,620,206
Part X
Other Liabilities. Complete if the organization answered 'Yes' to Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
Federal income taxes  
ACCRUED POSTRETIREMENT BENEFIT OBLIGATION 1,956,084
UNREALIZED LOSS ON INTEREST RATE SWAP 56,314,598
MSU COLLEGE OF HUMAN MEDICINE- CONTRIBUTION PAYABLE 2,500,000
CAPITAL LEASE 80,221





Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 60,850,903
2. Liability for uncertain tax positions In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII ..................................................
Schedule D (Form 990) 2013

Schedule D (Form 990) 2013
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return Complete if the organization answered 'Yes' to Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ....... 1 71,409,773
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains on investments .......... 2a 321,600
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d 1,468,592
e Add lines 2a through 2d ..................... 2e 1,790,192
3 Subtract line 2e from line 1..................... 3 69,619,581
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a  
b Other (Describe in Part XIII.) ........... 4b 5,436,401
c Add lines 4a and 4b....................... 4c 5,436,401
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 75,055,982
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' to Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ........... 1 81,715,569
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities .......... 2a  
b Prior year adjustments .............. 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d 20,577,203
e Add lines 2a through 2d...................... 2e 20,577,203
3 Subtract line 2e from line 1..................... 3 61,138,366
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a  
b Other (Describe in Part XIII.) ............ 4b 5,436,401
c Add lines 4a and 4b....................... 4c 5,436,401
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 66,574,767
Part XIII
Supplemental Information
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Return Reference Explanation
PART X, LINE 2: PART X, LINE 1(1) AND LINE 2: THERE ARE NO UNCERTAIN TAX POSITIONS RELATED TO VARI.
PART XI, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 1,468,592.
PART XI, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 5,401,058. STATE TAX REFUNDS 35,343.
PART XII, LINE 2D - OTHER ADJUSTMENTS: LOSS ON INTERST RATE SWAP 19,108,611. RENTAL EXPENSES 1,468,592.
PART XII, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 5,401,058. STATE TAX REFUNDS 35,343.
PART V THE VAN ANDEL INSTITUTE (A RELATED ORGANIZATION) MAINTAINS ENDOWED FUNDS FOR THE BENEFIT OF BOTH VARI AND THE VAN ANDEL EDUCATION INSTITUTE (A RELATED ORGANIZATION) TO FUND OPERATING EXPENSES.
PART XI AND XII, LINE 4B EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE.
Schedule D (Form 990) 2013

Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.Right pointing arrow large image Information about Schedule F (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 14b.
1
For grantmakers.Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? ...............................
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in region (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total expenditures
for and investments
in region
EAST ASIA & THE PACIFIC 0 1 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES 382,768
EUROPE 0 0 PROGRAM SERVICES REVIEW OF PAPER 2,000
EUROPE 0 0 UNRELATED TRADE OR BUSINESS FEE FOR SERVICES  
EUROPE 0 0 RESEARCH SERVICES LICENSING FEES  
           
           
           
           
           
           
           
           
           
           
           
           
           
3a Sub-total ..... 0 1 384,768
b Total from continuation sheets to Part I ... 0 0 0
c Totals (add lines 3a and 3b) 0 1 384,768
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2013
Schedule F (Form 990) 2013
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter ....MediumBullet
 
3
Enter total number of other organizations or entities .......................MediumBullet
 
Schedule F (Form 990) 2013
Schedule F (Form 990) 2013Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2013
Schedule F (Form 990) 2013
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes,"the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926)......................................
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A).......................................
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471)..............................
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621)...............................................
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships. (see Instructions for Form 8865)....................................
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to file Form 5713, International Boycott Report (see Instructions for Form 5713)................................................
Schedule F (Form 990) 2013
Schedule F (Form 990) 2013
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).
ReturnReference Explanation
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2013
Additional Data


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Software Version:  



Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," to Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990
lBullet Information about Schedule I (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number
52-2000823
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ....................................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Governments and Organizations in the United States. Complete if the organization answered "Yes" to
Form 990, Part IV, line 21, for any recipient that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government		 (b) EIN (c) IRC Code section
if applicable		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
non-cash assistance		 (h) Purpose of grant
or assistance






















2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................ Bullet Image
 
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2013

Schedule I (Form 990) 2013
Page 2
Part III
Grants and Other Assistance to Individuals in the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a)Type of grant or assistance (b)Number of
recipients		 (c)Amount of
cash grant		 (d)Amount of
non-cash assistance		 (e)Method of valuation (book,
FMV, appraisal, other)		 (f)Description of non-cash assistance
(1) GRADUATE STUDENT STIPENDS FOR MICHIGAN STATE UNIVERSITY STUDENTS 5 141,319 0    
(2) FOREIGN NATIONAL STIPENDS 12 60,588      










Part IV
Supplemental Information. Provide the information required in Part I, line 2, Part III, column (b), and any other additional information.
Return Reference Explanation
PART I, LINE 2: STIPENDS ARE PROVIDED TO THE RESEARCH STUDENTS FOR LIVING AND INSURANCE ASSISTANCE.
Schedule I (Form 990) 2013


Additional Data


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Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 23.
SchJMediumBullet Attach to Form 990. SchJMediumBullet See separate instructions.
SchJMediumBullet Information about Schedule J (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed in Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked in line 1a? ..
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed in Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ................
4a
Yes
 
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3) and 501(c)(4) organizations only must complete lines 5-9.
5
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization? .........................
5b
 
No
If "Yes," to line 5a or 5b, describe in Part III.
6
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ...........................
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," to line 6a or 6b, describe in Part III.
7
For persons listed in Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported in Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
 
No
9
If "Yes" to line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2013

Schedule J (Form 990) 2013
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported in Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation
reported as deferred
in prior Form 990
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
(1)DAVID VAN ANDELCHAIRMAN / CEO (i)
(ii)		 310,965
0 		85,054
0 		20,732
0 		133,230
0 		515
0 		550,496
0 		85,054
0
(2)DR GEORGE VANDE WOUDETRUSTEE/ INVESTIGATOR (i)
(ii)		 280,255
0 		0
0 		19,972
0 		25,500
0 		1,292
0 		327,019
0 		0
0
(3)TIMOTHY MYERSV.P. & CHIEF FINANCIAL OFFICER (i)
(ii)		 202,295
0 		32,779
0 		450
0 		70,760
0 		8,328
0 		314,612
0 		32,779
0
(4)DAVID WHITESCARVERSECRETARY/V.P. & CHIEF LEGAL OFFICER (i)
(ii)		 261,267
0 		76,243
0 		18,710
0 		120,346
0 		8,328
0 		484,894
0 		51,243
0
(5)DR JANA HALLCHIEF OPERATIONS OFFICER (i)
(ii)		 285,763
0 		15,000
0 		16,224
0 		97,544
0 		1,735
0 		416,266
0 		0
0
(6)DR H ERIC XUINVESTIGATOR (i)
(ii)		 275,613
0 		20,533
0 		450
0 		44,797
0 		8,328
0 		349,721
0 		20,533
0
(7)DR SCOTT JEWELLINVESTIGATOR (i)
(ii)		 275,109
0 		40,205
0 		1,980
0 		57,812
0 		8,327
0 		383,433
0 		25,795
0
(8)LOVE COLLINS IIIV.P. OF DEVELOPMENT, COMM. & MKTNG. (i)
(ii)		 251,626
0 		39,834
0 		1,290
0 		81,217
0 		8,327
0 		382,294
0 		39,834
0
(9)DR PATRIK BRUNDINVARI ASSOCIATE DIRECTOR OF RESEARCH (i)
(ii)		 395,776
0 		65,000
0 		14,457
0 		105,165
0 		7,633
0 		588,031
0 		43,763
0
(10)GERALD CALLAHANV.P. OF BUSINESS DEVELOPMENT (i)
(ii)		 221,140
0 		0
0 		10,414
0 		83,859
0 		1,291
0 		316,704
0 		0
0
(11)R JACK FRICK DONE 121111CHIEF ADMINISTRATIVE OFFICER -FORMER (i)
(ii)		 0
0 		26,585
0 		161,120
0 		0
0 		0
0 		187,705
0 		26,585
0
Schedule J (Form 990) 2013

Schedule J (Form 990) 2013
Page 3
Part III
Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II.
Also complete this part for any additional information.
Return Reference Explanation
PART I, LINE 1A VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES.
PART I, LINE 4A R. JACK FRICK RECEIVED SEVERANCE PAYMENTS OF $161,120 DURING CALENDAR YEAR 2013.
PART I, LINE 7 THREE NON-FIXED BONUSES WERE PAID AT THE DISCRETION OF THE CEO.
Schedule J (Form 990) 2013

Additional Data


Software ID:  
Software Version:  
Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990. SchKMediumBullet See separate instructions.
SchKMediumBulletInformation about Schedule K (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number
52-2000823
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer 		(i) Pool
financing
Yes No Yes No Yes No
A MICHIGAN STRATEGIC FUND
  		52-1417332   04-01-2013 220,000,000 REFUND BOND ISSUE 4/10/08   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired . . . . . . . . . . . . . .        
2 Amount of bonds legally defeased . . . . . . . . . . .        
3 Total proceeds of issue . . . . . . . . . . . . . . 220,000,000      
4 Gross proceeds in reserve funds . . . . . . . . . . . .        
5 Capitalized interest from proceeds . . . . . . . . . . .        
6 Proceeds in refunding escrows . . . . . . . . . . . .        
7 Issuance costs from proceeds . . . . . . . . . . . .        
8 Credit enhancement from proceeds . . . . . . . . . . .        
9 Working capital expenditures from proceeds . . . . . . . . .        
10 Capital expenditures from proceeds . . . . . . . . . . .        
11 Other spent proceeds . . . . . . . . . . . . . . 220,000,000      
12 Other unspent proceeds . . . . . . . . . . . . . .        
13 Year of substantial completion . . . . . . . . . . . .
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? . . . . . X              
15 Were the bonds issued as part of an advance refunding issue? . . . . .   X            
16 Has the final allocation of proceeds been made? . . . . . . . . X              
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? . . . . . . . . . . . . . . X              
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? . . . . . . .   X            
2 Are there any lease arrangements that may result in private business use of bond-financed property? . . . . . . . . . X              
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2013
Schedule K (Form 990) 2013
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? . . . . . . . . . . . . X              
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? X              
c Are there any research agreements that may result in private business use of bond-financed property? . . . . . . . . . . . . . . . X              
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? X              
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government . . SchKMediumBullet        
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government . . . . . . . SchKMediumBullet 0.950 %      
6 Total of lines 4 and 5 . . . . . . . . . . . . . 0.950 %      
7 Does the bond issue meet the private security or payment test? . . . . .   X            
8a Has there been a sale or disposition of any of the bond financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?. . . . . . . . . . . . . . . . .   X            
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of.        
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? . . . . . . . . . . . . .                
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2? . . . . . . . 		X              
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T? . . . . .   X            
2 If "No" to line 1, did the following apply? . . . .
a Rebate not due yet? . . . . . . . .   X            
b Exception to rebate? . . . . . . . .   X            
c No rebate due? . . . . . . . . X              
If you checked "No rebate due" in line 2c, provide in
Part VI the date the rebate computation was performed
3 Is the bond issue a variable rate issue? . . . . X              
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?   X            
b Name of provider . . . . . . . . .  
  		 
  		 
  		 
 
c Term of hedge . . . . . . . . . .        
d Was the hedge superintegrated? . . . .                
e Was the hedge terminated? . . . . . .                
Schedule K (Form 990) 2013
Schedule K (Form 990) 2013
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? . . . . . . . . .   X            
b Name of provider . . . . . . . . .  
  		 
  		 
  		 
 
c Term of GIC . . . . . . . . . .        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? . . . . .                
6 Were any gross proceeds invested beyond an available temporary period? . . . . . . . .   X            
7 Has the organization established written procedures to monitor the requirements of section 148? . . . X              
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations? X              
Part VI
Supplemental Information. Provide additional information for responses to questions on Schedule K (see instructions).
Return Reference Explanation
DATE REBATE COMPUTATION PERFORMED ISSUER NAME: MICHIGAN STRATEGIC FUND DATE THE REBATE COMPUTATION WAS PERFORMED: 11/30/2013
Schedule K (Form 990) 2013

Additional Data


Software ID:  
Software Version:  

Schedule L
(Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Transactions with Interested Persons
MediumBullet Complete if the organization answered
"Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c,
or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet Attach to Form 990 or Form 990-EZ. MediumBullet See separate instructions.
MediumBulletInformation about Schedule L (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Excess Benefit Transactions (section 501(c)(3) and section 501(c)(4) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1(a) Name of disqualified person (b) Relationship between disqualified person and organization (c) Description of transaction (d) Corrected?
Yes No





2
Enter the amount of tax incurred by organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image$
 
3
Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ....... Bullet Image$
 

Part II
Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22
(a) Name of interested person (b) Relationship with organization (c) Purpose of loan (d) Loan to or from the organization? (e)Original principal amount (f)Balance due (g) In default? (h) Approved by board or committee? (i)Written agreement?
To From Yes No Yes No Yes No
(1) PATRIK BRUNDIN HIGHEST COMPENSATION EMPLOYEE CONTRACT   X 25,000 9,657   No   No Yes  
Total ......Small Bullet $ 9,657
Part III
Grants or Assistance Benefitting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of assistance (d) Type of assistance (e) Purpose of assistance
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 50056A
Schedule L (Form 990 or 990-EZ) 2013
Schedule L (Form 990 or 990-EZ) 2013
Page 2
Part IV
Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested person and the organization (c) Amount of transaction (d) Description of transaction (e) Sharing of organization's revenues?
Yes No
(1) JVAE FOUNDATION
  		COMMON TRUSTEE 155,123 IT SVCS   No
Part V
Supplemental Information
Provide additional information for responses to questions on Schedule L (see instructions).
Return Reference Explanation
Schedule L (Form 990 or 990-EZ) 2013

Additional Data


Software ID:  
Software Version:  




SCHEDULE M
(Form 990)

Department of the Treasury
Internal Revenue Service
Noncash Contributions
Right pointing arrow large imageComplete if the organizations answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image Attach to Form 990.
Right pointing arrow large imageInformation about Schedule M (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Types of Property
(a)
Check if applicable 		(b)
Number of contributions or items contributed 		(c)
Noncash contribution amounts reported on
Form 990, Part VIII, line 1g 		(d)
Method of determining
noncash contribution amounts
1 Art—Works of art ....        
2 Art—Historical treasures .        
3 Art—Fractional interests ..        
4 Books and publications ..      
5 Clothing and household
goods ....... 		     
6 Cars and other vehicles ..        
7 Boats and planes ....        
8 Intellectual property ...        
9 Securities—Publicly traded .        
10 Securities—Closely held stock .        
11 Securities—Partnership, LLC,
or trust interests .... 		       
12 Securities—Miscellaneous ..        
13 Qualified conservation
contribution—Historic
structures ..... 		       
14 Qualified conservation
contribution—Other ... 		       
15 Real estate—Residential .        
16 Real estate—Commercial ..        
17 Real estate—Other ...        
18 Collectibles .....        
19 Food inventory ...        
20 Drugs and medical supplies .        
21 Taxidermy ......        
22 Historical artifacts ....        
23 Scientific specimens ..        
24 Archeological artifacts ...        
25 Other Right pointing arrow large image ( CAPITAL EQUIP ) X 1 152,458 FMV
26 Other Right pointing arrow large image ( EQUIPMENT ) X 1 400 FMV
27 Other Right pointing arrow large image ( FOOD ) X 1 53 FMV
28 Other Right pointing arrow large image ( )
29
Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement ...
29
0
Yes
No
30a
During the year, did the organization receive by contribution any property reported in Part I, lines 1 through 28, that
it must hold for at least three years from the date of the initial contribution, and which is not required to be used
for exempt purposes for the entire holding period? ..................
30a
 
No
b
If "Yes," describe the arrangement in Part II.
31
Does the organization have a gift acceptance policy that requires the review of any non-standard contributions?
31
 
No
32a
Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash
contributions? ..........................
32a
 
No
b
If "Yes," describe in Part II.
33
If the organization did not report an amount in column (c) for a type of property for which column (a) is checked,
describe in Part II.
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 51227J
Schedule M (Form 990) (2013)
Schedule M (Form 990) (2013)
Page 2
Part II
Supplemental Information. Provide the information required by Part I, lines 30b,
32b, and 33, and whether the organization is reporting in Part I, column (b), the number of contributions, the number of items received, or a combination of both. Also complete this part for any additional information.
Return Reference Explanation
PART I, COLUMN (B): NUMBER OF CONTRIBUTIONS IS BASED ON NUMBER OF GIFTS.
Schedule M (Form 990) (2013)
Additional Data


Software ID:  
Software Version:  
SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
MediumBullet Information about Schedule O (Form 990 or 990-EZ) and its instructions is at
www.irs.gov/form990.
OMB No. 1545-0047
2013
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Return Reference Explanation
FORM 990, PART III, LINE 2 IN 2014, VARI STARTED THE CENTER FOR EPIGENETICS. THE CENTER IS DEDICATED TO THE STUDY OF EPIGENETICS AND EPIGENOMICS IN HEALTH AND DISEASE, WITH THE ULTIMATE GOAL OF DEVELOPING NOVEL THERAPIES TO TREAT CANCER AND NEURODEGENERATIVE DISEASES.
FORM 990, PART VI, SECTION A, LINE 2 VARI AND VAEI SHARE COMMON MANAGEMENT. AS OFFICERS OF VARI, DAVID VAN ANDEL, DR. JANA HALL, TIMOTHY MYERS AND DAVID WHITESCARVER INTERACT AND WORK TOGETHER WITH DR. STEVE TRIEZENBERG, AN OFFICER OF VAEI.
FORM 990, PART VI, SECTION A, LINE 7A THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY.
FORM 990, PART VI, SECTION B, LINE 11 FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD FOR REVIEW AND FINAL APPROVAL PRIOR TO FILING WITH THE IRS.
FORM 990, PART VI, SECTION B, LINE 12C VARI HAS WRITTEN CONFLICT OF INTEREST ("COI") POLICIES AND PROCEDURES (ADMINISTERED BY VAN ANDEL INSTITUTE) WHICH ADMINISTER AND ENFORCE A PROCESS TO IDENTIFY, EVALUATE, AND MANAGE POTENTIAL CONFLICTS OF INTEREST. THESE POLICIES HAVE BEEN BOARD APPROVED. VAI ADMINISTERS THE COI POLICIES AND PROCEDURES THROUGH TWO COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). THE COI POLICIES AND PROCEDURES APPLY TO AND SERVE AS A GUIDE FOR EVERYONE IN THE ORGANIZATION. THEY 1) PROVIDE A USEFUL RESOURCE WHEN DEVELOPING ACTIVITIES OR RELATIONSHIPS WITH OUTSIDE ENTITIES OR PERSONS, AND 2) ESTABLISH COMMITTEES TO REVIEW AND MANAGE POTENTIAL CONFLICTS OF INTEREST AS THEY MAY ARISE. THE CC, CHAIRED BY THE CHIEF LEGAL OFFICER, REQUIRES ANNUAL AND UPDATED DISCLOSURES BY COVERED PERSONS AND REVIEWS AND APPROVES MANAGEMENT PLANS. THE INSTITUTIONAL COI POLICIES AND PROCEDURES SERVE AS A GUIDE FOR MEMBERS OF THE BOARDS OF TRUSTEES AND SENIOR EXECUTIVES. IN THE EVENT A POTENTIAL COI ARISES AT THE BOARD OR SENIOR EXECUTIVE LEVEL, THE ICOIC MEETS TO REVIEW AND DECIDE HOW TO MANAGE SUCH POTENTIAL CONFLICTS OF INTEREST IN ACCORDANCE WITH THE COI POLICIES AND PROCEDURES.
FORM 990, PART VI, SECTION B, LINE 15 COMPARABILITY DATA FROM EXPERT THIRD PARTY IS OBTAINED AND REVIEWED BY THE INDEPENDENT, JOINT COMPENSATION COMMITTEE OF VAN ANDEL RESEARCH INSTITUTE AND RELATED ORGANIZATIONS TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE.
FORM 990, PART VI, SECTION C, LINE 19 THE CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST.
FORM 990, PART XI, LINE 9: LOSS ON INTEREST RATE SWAP -19,108,611. CHANGE IN BALANCE SHEET PRESENTATION OF TMS 286,858.
FORM 990, PART III, LINE 2 VAN ANDEL RESEARCH INSTITUTE (VARI) IS DEDICATED TO DETERMINING THE EPIGENETIC, GENETIC, MOLECULAR, AND CELLULAR ORIGINS OF CANCER, PARKINSON'S DISEASE, AND OTHER ILLNESSES AND TRANSLATING THOSE FINDINGS INTO EFFECTIVE THERAPIES. THE INSTITUTE'S SCIENTISTS WORK IN ON-SITE LABORATORIES AND PARTICIPATE IN COLLABORATIONS THAT SPAN THE GLOBE. THE INSTITUTE IS ORGANIZED INTO THE CENTER FOR CANCER AND CELL BIOLOGY, THE CENTER FOR EPIGENETICS, AND THE CENTER FOR NEURODEGENERATIVE SCIENCE. THE CORE TECHNOLOGIES AND SERVICES GROUP PROVIDES VALUABLE ON-SITE CAPABILITIES IN IMAGING, PATHOLOGY, BIOINFORMATICS, FLOW CYTOMETRY, A VIVARIUM, AND A BIOREPOSITORY. RESEARCH BY VARI SCIENTISTS IS PUBLISHED IN MAJOR PEER-REVIEWED JOURNALS, INCLUDING, IN 2014, AMERICAN JOURNAL OF CANCER RESEARCH, AMERICAN JOURNAL OF PATHOLOGY, ARTHRITIS RESEARCH AND THERAPY, CANCER CELL, CANCER RESEARCH, GENOME RESEARCH, JOURNAL OF BONE AND MINERAL RESEARCH, JOURNAL OF PARKINSON'S DISEASE, MOLECULAR AND CELLULAR BIOLOGY, MOLECULAR ONCOLOGY, NATURE MEDICINE, NEOPLASIA, NEURO-ONCOLOGY, NEUROSCIENCE, ONCOGENE, PLOS ONE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES U.S.A., PSYCHONEUROENDOCRINOLOGY, AND TRANSLATIONAL RESEARCH, AMONG OTHERS. IN 2014, PETER A. JONES, PH.D., D. SC., BECAME THE RESEARCH DIRECTOR AND CHIEF SCIENTIFIC OFFICER OF VAN ANDEL RESEARCH INSTITUTE. DR. JONES WAS BORN IN SOUTH AFRICA, RAISED AND ATTENDED COLLEGE IN RHODESIA (NOW ZIMBABWE), AND RECEIVED HIS PH.D. FROM THE UNIVERSITY OF LONDON. HE JOINED THE UNIVERSITY OF SOUTHERN CALIFORNIA IN 1977, ATTAINING THE RANK OF PROFESSOR IN 1985 AND DISTINGUISHED PROFESSOR IN 1999. HE ALSO SERVED AS DIRECTOR OF THE USC NORRIS COMPREHENSIVE CANCER CENTER BETWEEN 1993 AND 2011. HIS LABORATORY DISCOVERED THE EFFECTS OF 5-AZACYTIDINE ON DNA METHYLATION AND LINKED THIS PROCESS TO THE ACTIVATION OF SILENCED GENES. HE IS KNOWN FOR HIS STUDIES ON THE MOLECULAR BIOLOGY OF CANCER AND OF BASIC MECHANISMS OF DNA METHYLATION AND ITS ROLE IN CANCER AND DIFFERENTIATION. DR. JONES IS A PAST PRESIDENT OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND WAS ELECTED AS A FELLOW OF THE ACADEMY OF THE AACR IN 2013. HE HAS PUBLISHED MORE THAN 300 SCIENTIFIC PAPERS AND RECEIVED SEVERAL HONORS, INCLUDING THE OUTSTANDING INVESTIGATOR GRANT FROM THE NATIONAL CANCER INSTITUTE. HE AND HIS COLLEAGUE DR. STEPHEN BAYLIN SHARED BOTH THE KIRK A. LANDON AWARD FOR BASIC CANCER RESEARCH FROM THE AACR IN 2009 AND THE MEDAL OF HONOR FROM THE AMERICAN CANCER SOCIETY IN 2011.
FORM 990, PART III, LINE 4A LINE 4A - PROGRAM SERVICE ACTIVITY #1 CENTER FOR CANCER AND CELL BIOLOGY THE CENTER FOR CANCER AND CELL BIOLOGY, DIRECTED BY BART WILLIAMS, PH.D., COMPRISES 14 LABORATORIES ENGAGED IN BASIC RESEARCH IN MOLECULAR AND STRUCTURAL BIOLOGY AND IN TRANSLATIONAL RESEARCH ON CANCERS, THE TUMOR MICROENVIRONMENT, AND SKELETAL DISEASES. INVESTIGATORS WITHIN THE CENTER IN 2014 RECEIVED AN R01 RENEWAL FROM THE NATIONAL INSTITUTES OF HEALTH, A NEW AWARD FROM THE DEPARTMENT OF DEFENSE, A RENEWAL AWARD FROM THE MICHAEL J. FOX FOUNDATION, A NEW AWARD FROM THE COFFMAN CHARITABLE TRUST, AND TWO AWARDS FROM THE MICHIGAN ECONOMIC DEVELOPMENT CORPORATION (MEDC). THE VAN ANDEL RESEARCH INSTITUTE PATHWAY OF HOPE INITIATIVE PROGRESSED IN 2014 UNDER THE DIRECTION OF JEFFREY MACKEIGAN, ASSOCIATE PROFESSOR AND HEAD OF THE LABORATORY OF SYSTEMS BIOLOGY. TUBEROUS SCLEROSIS COMPLEX (TSC) CAUSES NON-CANCEROUS TUMORS IN MAJOR ORGANS, AND PATIENTS AFFLICTED WITH DISEASE OFTEN SUFFER FROM EPILEPSY, LEARNING DISABILITIES AND OTHER COMPLICATIONS. VARI'S PATHWAY OF HOPE PROJECT INVOLVES TSC INVESTIGATORS FROM ACROSS THE UNITED STATES, WITH FUNDING FROM THE MICHIGAN STRATEGIC FUND, BLUE CROSS BLUE SHIELD OF MICHIGAN, GREAT LAKES SCRIP, ROCKFORD CONSTRUCTION, COLLIERS INTERNATIONAL, TEAM HANNAH TSC, AND INDIVIDUAL DONORS. THE INITIATIVE INVOLVES A COMBINATION OF BASIC BIOLOGY, TRANSLATIONAL AND CLINICAL APPROACHES, WITH THE GOAL OF DEVELOPING NEW, EFFECTIVE TREATMENTS FOR INDIVIDUALS WITH TSC. THE TSC RESEARCH TEAM HAS SCREENED FOR GENES NEVER BEFORE LINKED TO TSC AND IS INVESTIGATING SEVERAL THAT ARE INTRIGUING. THE PATHWAY OF HOPE TEAM HAS ALSO BEGUN A PERSONALIZED MEDICINE FEASIBILITY STUDY, EVALUATING THE TEAM'S ABILITY TO DEVELOP INDIVIDUALIZED TREATMENT PLANS FROM A PATIENT'S GENOMIC DATA. TSC RESEARCH IS BEING FUNDED IN PART THROUGH THE BILL VAN REGENMORTER COLLABORATIVE FOR TRANSLATIONAL BIOMEDICAL RESEARCH, WHICH IS ADMINISTERED BY THE MEDC. RESEARCH CONTINUES INTO THE MIG6 GENE AND ITS RELATIONSHIP TO OSTEOARTHRITIS. INJURED JOINTS ARE PRONE TO DEVELOPING OSTEOARTHRITIS (OA), AND A LACK OF THE MIG-6 PROTEIN INCREASES THE DAMAGE FOUND IN JOINTS FOLLOWING TRAUMA. BONE MINERAL DENSITY AND TRABECULAR THICKNESS AND NUMBER WERE FOUND TO BE LOWER IN SURGICALLY TREATED KNEES FROM MICE LACKING THE MIG6 GENE (JOINER ET AL., ARTHRITIS RESEARCH AND THERAPY 16(2): R81). ANOTHER STUDY EXPLORED THE JOINT TISSUES IN WHICH MIG-6 IS EXPRESSED AND THE ROLE CHONDROCYTES PLAY IN THE OA-LIKE DISORDER CAUSED BY MIG-6 DEFICIENCY IN MICE. MIG-6 WAS FOUND TO BE CRUCIAL IN MAINTAINING JOINT HOMEOSTASIS AND IN REGULATING CHONDROCYTE ACTIVITY IN SYNOVIAL JOINTS, WHICH ARE FOUND IN THE KNEE, SHOULDER, HIP, AND ELBOW, AMONG OTHERS (STAAL ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES U.S.A. 111(7): 2590-2595). MITOCHONDRIA ARE THE ENERGY-PRODUCING ORGANELLES OF A CELL. THE SIZE OF MITOCHONDRIA, LARGE VS. COMPACT, WAS FOUND TO CORRELATE WITH MITOCHONDRIAL FISSION OR FUSION EVENTS, RESPECTIVELY (WESTRATE ET AL., PLOS ONE 9(4): E95265). IN RAPIDLY DIVIDING CANCER CELLS, THE MITOCHONDRIA MUST FRAGMENT (FISSION) PRIOR TO CELL DIVISION. FORCED FUSION OF MITOCHONDRIA INHIBITED THE DIVIDING OF CELLS, AND EXTENDED PERIODS OF SUCH FUSION CAUSED THE CELLS TO DIE. THUS, INHIBITING THE REGULATION OF MITOCHONDRIAL FISSION MAY BE A STRATEGY FOR TARGETING CANCER CELLS (WESTRATE ET AL., PLOS ONE 9(3): E91911). ANOTHER STUDY IDENTIFIED A MITOCHONDRIAL ADENYLATE KINASE ENZYME THAT REGULATES CELLULAR ATP LEVELS; THE EXPRESSION OF THAT ENZYME CORRELATED WITH THE SURVIVAL OF GLIOMA PATIENTS. THIS STUDY MAPPED THE BIOENERGETIC LANDSCAPE OF MORE THAN 1000 MITOCHONDRIAL PROTEINS SUBSTRATES, AND IT IS THE BEGINNING OF LINKING KEY METABOLIC GENES WITH CLINICAL DISEASE OUTCOME (LANNING ET AL., CELL REPORTS 7(3): 907-917). STUDIES OF MOLECULAR STRUCTURES AND THEIR PHYSICAL INTERACTIONS HAVE BEEN PROCEEDING ON SEVERAL FRONTS IN 2014. GLUCOCORTICOIDS ARE VALUABLE FOR TREATING DISEASES SUCH AS ASTHMA, LEUKEMIA, AND AUTOIMMUNE DISEASES, BUT THE DRUGS HAVE BOTH BENEFICIAL AND ADVERSE EFFECTS. STUDIES OF THE GLUCOCORTICOID RECEPTOR SHOWED THAT THE Q642 AMINO ACID IN THE LIGAND-BINDING POCKET IS KEY TO THE HIGH POTENCY OF THE GLUCOCORTICOID MOMETASONE FUROATE. THIS STRUCTURE-BASED DESIGN LED TO SYNTHESIS OF SEVERAL NOVEL GLUCOCORTICOIDS WITH MUCH IMPROVED POTENCY AND EFFICACY. THIS RESEARCH PROVIDES A RATIONAL BASIS FOR DEVELOPING DRUGS THAT HAVE AN IMPROVED RATIO OF BENEFICIAL TO ADVERSE EFFECTS (HE ET AL., CELL RESEARCH 24(6): 713-726). A STUDY OF THE SHP RECEPTOR, WHICH ACTS AS A REPRESSOR TO REGULATE BILE ACIDS AND CHOLESTEROL METABOLISM, HAS DEMONSTRATED INTERACTIONS THAT CONTROL SHP ACTIVITY. THE EID1 PROTEIN WAS FOUND TO HAVE A BINDING SITE ON SHP, UNEXPECTEDLY LOCATED AT THE N TERMINUS OF THE RECEPTOR, WHICH MAY HAVE IMPLICATIONS FOR TRANSCRIPTIONAL REPRESSION BY SIMILAR NUCLEAR RECEPTORS. UNDERSTANDING THE FUNCTION AND MECHANISM OF ACTION OF SHP WILL HELP IN DEVELOPING DRUGS TO TREAT METABOLIC DISEASES ARISING FROM BILE ACID AND CHOLESTEROL IMBALANCES (ZHI ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES U.S.A. 111(2): 839-844). AN ONGOING STUDY CONTINUES INTO ABSCISIC ACID, A PLANT HORMONE CRUCIAL TO THE ADAPTATION OF PLANTS TO DROUGHT CONDITIONS. VARI RESEARCHERS HAVE FOUND THAT THE HORMONE CAUSES THE GENERATION OF HYDROGEN PEROXIDE, WHICH INHIBITS THE PHOSPHATASE ENZYME HAB1, RESULTING IN THE CLOSING OF PLANT PORES (STOMATA) AND THUS PREVENTING LOSS OF WATER THROUGH TRANSPIRATION (SRIDHARAMURTHY ET AL., PLOS ONE 9(12): E113643). PROGRESS CONTINUES ON THE STUDY OF A VARIETY OF CANCERS. THE AGGRESSIVENESS OF MESENCHYMAL PANCREATIC CANCER CELLS HAS BEEN LINKED TO GENETIC CHANGES IN THE CDKN2A AND RELATED GENES. WHOLE-GENOME COMPARATIVE GENOMIC HYBRIDIZATION MEASUREMENTS ON EPITHELIAL-LIKE AND MESENCHYMAL-LIKE PANCREATIC CANCER CELL LINES FOUND 20 ALTERED GENES THAT SHOWED A MAJOR DIFFERENCE BETWEEN THE GROUPS. ALL 20 ALTERATIONS (18 DELETIONS AND 2 AMPLIFICATIONS) WERE MORE PREVALENT IN THE MESENCHYMAL GROUP (SINHA ET AL., MOLECULAR ONCOLOGY 8(7): 1253-1265). ANOTHER PROJECT STUDIED TWO ACRIDINE DERIVATIVES THAT ACT AS INHIBITORS OF AUTOPHAGY, A DYNAMIC CELL SURVIVAL MECHANISM. IN MELANOMA CELLS DRIVEN BY THE BRAF GENE (WHICH HELPS CONTROL CELL GROWTH AND IS MUTATED IN SOME CANCERS), BOTH DERIVATIVES ACTED TO SENSITIZE THE CELLS TO THE CANCER-THERAPY DRUG VEMURAFENIB (GOODALL ET AL., AUTOPHAGY 10(6): 1120-1136). THE CHROMATIN REMODELING PROTEIN ING4 IS REQUIRED FOR NORMAL DIFFERENTIATION OF PROSTATE CELLS, AND EXPRESSION OF THIS PROTEIN IS LOST IN THE MAJORITY OF PROSTATE CANCERS. THAT LOSS MAY BE A FACTOR IN THE DEVELOPMENT OF SUCH CANCER, AND THERE MAY BE SUBTYPES OF PROSTATE CANCER BASED ON LOSS OF ING4 ALONE OR OF BOTH THE ING4 AND PTEN PROTEINS (BERGER ET AL., CANCER RESEARCH 74(12): 3357-3368.) SOLID TUMORS SUCH AS OSTEOSARCOMA OFTEN HAVE OXYGEN-POOR (HYPOXIC) ENVIRONMENTS. UNDER SUCH CONDITIONS, A VARI STUDY FOUND THAT OSTEOSARCOMA CELLS HAVE LOWER WNT SIGNALING AND THE CANCER CELLS ARE RESISTANT TO DOXORUBICIN. HOWEVER, BY A FURTHER LOWERING OF WNT SIGNALING, THE CANCER CELLS CAN BE MADE SENSITIVE TO DOXORUBICIN TREATMENT (SCHOLTEN ET AL., PLOS ONE, 9(10): E111431). IN A STUDY OF A BENIGN TUMOR CALLED ANEURYSMAL BONE CYST (ABC), THE RANKL SIGNALING PATHWAY WAS SHOWN TO BE ESSENTIAL FOR PROGRESSION OF THIS TUMOR, SUGGESTING FURTHER STUDY OF RANKL-TARGETED THERAPY AS AN ALTERNATIVE TO SURGERY. THE SAME ARTICLE REVIEWED A CASE STUDY OF SUCCESSFUL TARGETING OF AN AGGRESSIVE SACRAL ABC IN A 5-YEAR-OLD BOY THROUGH USE OF RANKL INHIBITION PLUS DENOSUMAB (PELLE ET AL., TRANSLATIONAL RESEARCH 164(2): 139-148). VARI RESEARCHERS HAVE SHOWN THAT HIGH LEVELS OF THE MICRORNA MIR-21, A SMALL NON-CODING RNA, IN THE TUMOR MICROENVIRONMENT-BUT NOT IN THE CANCER CELLS THEMSELVES-ARE ASSOCIATED WITH WORSE CLINICAL OUTCOMES FOR PATIENTS WITH "TRIPLE-NEGATIVE" BREAST CANCER. THIS FINDING SUGGESTS THAT ALTERED MIR-21 EXPRESSION PROVIDES CLINICALLY RELEVANT INFORMATION, THUS IDENTIFYING A POSSIBLE PROGNOSTIC BIOMARKER FOR THIS DISEASE (MACKENZIE ET AL., AMERICAN JOURNAL OF PATHOLOGY 184(12): 3217-3225).
FORM 990, PART III, LINE 4B LINE 4B - PROGRAM SERVICE ACTIVITY #2 CENTER FOR EPIGENETICS THE CENTER, ESTABLISHED IN 2014 AND DIRECTED BY PETER JONES, PH.D., D.SC., COMPRISES EIGHT LABORATORIES STUDYING EPIGENETICS AND EPIGENOMICS AND THE ROLE OF EPIGENETIC DYSFUNCTION IN DISEASES SUCH AS CANCER AND NEURODEGENERATIVE DISEASE, CARDIOVASCULAR DISEASE, AND VIRAL TRANSCRIPTION. FOUR NEW FACULTY, THREE WITH FEDERAL FUNDING, WERE RECRUITED TO THE CENTER IN 2014. IN 2014, CENTER RESEARCHERS RECEIVED A NEW GRANT AWARD THROUGH THE BILL VAN REGENMORTER COLLABORATIVE TO ESTABLISH A CENTER OF EXCELLENCE IN EPIGENETICS, AS WELL AS A DEPARTMENT OF DEFENSE SUBAWARD ON THE USE OF EPIGENETIC THERAPY FOR OVARIAN CANCER. IN FEBRUARY 2014, PETER JONES BECAME THE RESEARCH DIRECTOR AND CHIEF SCIENTIFIC OFFICER OF VAN ANDEL RESEARCH INSTITUTE (VARI). WITH HIM CAME HIS ROLE AS CO-LEADER WITH STEPHEN BAYLIN, M.D., OF JOHNS HOPKINS UNIVERSITY- OF THE STAND UP TO CANCER (SU2C) EPIGENETICS DREAM TEAM, WHICH WAS LAUNCHED IN 2009 TO FOCUS ON EPIGENETIC THERAPY IN CANCER TREATMENT. THEIR LEADERSHIP HAS EVOLVED THAT TEAM INTO THE VARI-SU2C EPIGENETICS DREAM TEAM, WHICH INCLUDES CHARLES RUDIN, M.D., PH.D., MEMORIAL SLOAN KETTERING CANCER CENTER IN NEW YORK; JEAN-PIERRE ISSA, M.D., AND PATRICIA KROPF, M.D., TEMPLE UNIVERSITY AND FOX CHASE CANCER CENTER IN PHILADELPHIA; KIRSTEN GRONBAEK, M.D., D.MSC., RIGSHOSPITALET, UNIVERSITY OF COPENHAGEN; AND ANTHONY EL-KHOUEIRY, M.D., UNIVERSITY OF SOUTHERN CALIFORNIA NORRIS COMPREHENSIVE CANCER CENTER. IN OCTOBER 2014, VARI COMMITTED TO PROVIDING $7.5 MILLION IN FUNDING TO CONTINUE THE WORK OF THE TEAM. AS BEFORE, THE TEAM WILL FOCUS ON EPIGENETIC MECHANISMS IN CELLS, WHICH HELP CONTROL WHETHER GENES ARE TURNED ON OR OFF WITHOUT CHANGING THE DNA SEQUENCE ITSELF. VARI'S SUPPORT OVER THREE YEARS WILL ALLOW THE TEAM TO MOVE FORWARD WITH MORE EXTENSIVE CLINICAL TRIALS IN OTHER CANCER TYPES AND ALLOW THEM TO TEST ADDITIONAL EPIGENETIC THERAPY STRATEGIES TO IMPROVE UPON THE PROGRESS ALREADY MADE. THE TEAM WILL CONTINUE TO BE PEER-REVIEWED BY THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. IN EARLY 2014, VAN ANDEL RESEARCH INSTITUTE AND SPECTRUM HEALTH BROUGHT WORLD-RENOWNED CARDIOVASCULAR RESEARCHER AND CARDIOLOGIST STEFAN JOVINGE, M.D., PH.D., TO GRAND RAPIDS. JOVINGE LEADS TEAMS OF RESEARCHERS AND CLINICIANS AT THE SPECTRUM HEALTH FREDERIK MEIJER HEART & VASCULAR INSTITUTE AND VAN ANDEL RESEARCH INSTITUTE IN AN EFFORT TO STIMULATE REGENERATIVE MEDICINE FOR HEART DISEASE. THE RESEARCH WILL HAVE FOUR AREAS OF FOCUS: CELL ENGINEERING; MULTI-CENTER PATIENT TREATMENT AND CLINICAL TRIALS; CELL SOURCE IDENTIFICATION AND SCIENTIFIC TRAINING; AND DEVELOPMENT FOR FUTURE RESEARCHERS INCLUDING INTERNS, FELLOWS, AND GRADUATE STUDENTS. DR. JOVINGE EARNED HIS MEDICAL DEGREE AND PH.D. FROM KAROLINSKA INSTITUTE IN STOCKHOLM, SWEDEN. HE ALSO COMPLETED A RESEARCH FELLOWSHIP IN THE DEPARTMENT OF CARDIOLOGY AT THE CEDARS-SINAI RESEARCH INSTITUTE AT THE UNIVERSITY OF CALIFORNIA LOS ANGELES. IN A STUDY OF ALTERATIONS AT SPECIFIC EPIGENETIC REGULATORY ELEMENTS IN PROSTATE AND BREAST CANCER CELLS, A GLOBAL RECONFIGURATION OF NUCLEOSOME-DEPLETED REGIONS (NDRS) WAS FOUND AT DISTAL ELEMENTS, COUPLED WITH A SUBSTANTIAL REORGANIZATION OF THE CANCER METHYL-GROUP ADDITIONS ONTO DNA. KEY TRANSCRIPTION FACTOR BINDING SITES ALSO SHOWED EXTENSIVE PERIPHERAL NUCLEOSOME PHASING, SUGGESTING THE POTENTIAL FOR SUCH SITES TO ORGANIZE NDRS GENOME-WIDE AND CONTRIBUTE TO DEREGULATION OF CANCER EPIGENOMES. GIVEN THAT NUCLEOSOMES "PACKAGE" DNA IN AN INACTIVE STATE, THESE EVENTS MAY CONTRIBUTE TO AN ALTERED GENOME-WIDE ARCHITECTURE AND EPIGENETIC DEREGULATION IN MALIGNANCY (TABERLAY ET AL., GENOME RESEARCH 24(9): 1421-1432). DBF4-DEPENDENT KINASE (DDK) IS OVEREXPRESSED IN MANY TUMOR CELLS, AND ITS INHIBITION CAUSES APOPTOSIS OF DIVERSE CANCER CELL TYPES. THE BENZOFUROPYRIMIDINONE-BASED DDK INHIBITOR XL413 WAS STUDIED FOR ITS EFFECTS WHEN USED ON TUMOR CELL LINES. WHILE XL413 WAS AN EFFECTIVE BIOCHEMICAL INHIBITOR OF DDK IN THE CELL LINES, IT HAD SIGNIFICANT ANTI-PROLIFERATIVE ACTIVITY AGAINST ONLY ONE OF THE 10 LINES TESTED. IN ADDITION, SOME 400 OTHER KINASE INHIBITORS WERE SCREENED, IDENTIFYING SEVERAL POTENTIAL DDK INHIBITORS THAT HAVE CHEMICAL STRUCTURES DIFFERENT FROM THOSE OF KNOWN DDK INHIBITORS (SASI ET AL., PLOS ONE 9(11): E113300).
FORM 990, PART III, LINE 4C LINE 4C - PROGRAM SERVICE ACTIVITY #3 CENTER FOR NEURODEGENERATIVE SCIENCE THE CENTER FOR NEURODEGENERATIVE SCIENCE WAS ESTABLISHED IN 2011 UNDER THE LEADERSHIP OF PATRIK BRUNDIN, M.D., PH.D., WHO IS ALSO ASSOCIATE RESEARCH DIRECTOR OF VARI. THE CENTER CURRENTLY HAS FIVE LABORATORIES STUDYING PARKINSON'S DISEASE, AGING, PRIONS, AND THE RELATIONSHIP BETWEEN DEPRESSION, SUICIDE, AND BRAIN INFLAMMATION. ONE NEW FACULTY MEMBER WAS RECRUITED IN 2014. CENTER RESEARCHERS RECEIVED NEW GRANT AWARDS FROM THE BILL VAN REGENMORTER COLLABORATIVE, THE CURE PARKINSON'S TRUST, AND FROM THE MICHAEL J. FOX FOUNDATION DURING 2014. IN 2014, VARI BEGAN AN INITIATIVE WITH THE UK-BASED RESEARCH CHARITY THE CURE PARKINSON'S TRUST TO IDENTIFY NEW TREATMENTS FOR PARKINSON'S DISEASE. THE COLLABORATION, CALLED THE LINKED CLINICAL TRIALS (LCT) INITIATIVE, IS AIMED AT REPOSITIONING MEDICATIONS APPROVED TO TREAT OTHER DISEASES THAT HAVE ALSO SHOWN PROMISE IN PRECLINICAL LABORATORY EXPERIMENTS FOR TREATING PARKINSON'S DISEASE. THE LCT INITIATIVE COULD SIGNIFICANTLY REDUCE THE TIME AND COST OF MOVING NEW PARKINSON'S TREATMENTS FROM THE LAB TO CLINICAL USE. THE UNDERLYING PREMISE IS THAT CONDUCTING SMALLER, MORE COST-EFFECTIVE TRIALS WITH SIMILAR PROTOCOLS, PATIENTS, AND OUTCOMES WILL ALLOW SCIENTISTS TO SEE WHICH DRUGS ARE MOST EFFECTIVE, WHILE MAXIMIZING THE NUMBER OF TRIALS CONDUCTED. LARGE-SCALE PARKINSON'S DISEASE CLINICAL TRIALS ARE RARE BECAUSE OF PROHIBITIVELY HIGH COSTS, AND THE LACK OF RELIABLE BIOMARKERS AND MODELS FOR THE DISEASE. THE FOCUS ON DRUGS ALREADY APPROVED FOR TREATING OTHER DISEASES WILL SIGNIFICANTLY REDUCE THE TIME AND FUNDING REQUIRED TO BRING AN EFFECTIVE NEW TREATMENT TO MARKET. VARI STUDIES ON PARKINSON'S DISEASE INCLUDE A PROJECT STUDYING ADENO-ASSOCIATED VIRUS (AAV) VECTORS, WHICH ARE USED TO DELIVER GENES IN CLINICAL TRIALS. IN RATS PRE-IMMUNIZED WITH WILD-TYPE AAV-2, INTRACEREBRAL GENE DELIVERY BASED ON AAV-2 WAS COMPROMISED (71% LOWER). BY CONTRAST, LOCAL NEUROINFLAMMATORY RESPONSE TO INTRASTRIATAL A 6-OHDA INJECTION, WHICH MIMICS PARKINSON'S DISEASE NEURONAL DAMAGE, DID NOT AFFECT VIRAL VECTOR-MEDIATED TRANSGENE EXPRESSION. THE RESULTS EMPHASIZE THE IMPORTANCE OF MONITORING CIRCULATING AAV-SPECIFIC NEUTRALIZING ANTIBODIES IN PATIENTS RECEIVING THERAPY USING AAV VECTORS (JANELIDZE ET AL., JOURNAL OF GENE MEDICINE 16(910): 300308). MUTATIONS IN THE LEUCINE-RICH REPEAT KINASE 2 (LRRK2) GENE CAUSE LATE-ONSET, AUTOSOMAL DOMINANT PARKINSON'S DISEASE (PD), AND SUCH MUTATIONS ARE THE MOST COMON CAUSE OF FAMILIAL PD. TO DIRECTLY EXPLORE THE EFFECT OF MUTANT LRRK2 ON THE NIGROSTRIATAL DOPAMINERGIC PATHWAY, WHICH IS DEGRADED IN PD, CONDITIONAL TRANSGENIC MICE WERE BRED THAT SELECTIVELY EXPRESS THE HUMAN R1441C MUTATION OF LRRK2 IN THEIR DOPAMINERGIC NEURONS. THE MUTANT LRRK2 DID NOT PRODUCE DEGENERATION OF SUBSTANTIA NIGRA DOPAMINERGIC NEURONS OR STRIATAL DOPAMINE DEFICITS IN MICE UP TO 2 YEARS OF AGE, AND NO ABNORMAL PROTEIN INCLUSIONS CONTAINING A-SYNUCLEIN, TAU, UBIQUITIN OR AUTOPHAGY MARKERS WERE FOUND. EARLY RESULTS FROM THESE NOVEL R1441C LRRK2 CONDITIONAL TRANSGENIC MICE REVEALED CHANGES IN DOPAMINERGIC NEURONAL MORPHOLOGY WITH ADVANCING AGE. THIS NEW MODEL WILL BE A USEFUL TOOL FOR EXPLORING THE PATHOGENIC MECHANISMS UNDERLYING THE R1441C LRRK2 MUTATION IN PD (TSIKA ET AL., NEUROBIOLOGY OF DISEASE 71: 345-358). THE DEVELOPMENT OF ALZHEIMER'S DISEASE PATHOLOGY FOLLOWS A SPATIOTEMPORAL PATTERN. IN A TRANSGENIC MOUSE MODEL, AMYLOID-BETA (A BETA) PATHOLOGY, WHICH IS IMPLICATED IN HUMAN ALZHEIMER'S, SPREADS ALONG ANATOMICALLY CONNECTED STRUCTURES. IN THIS STUDY, NEURONS TO AND FROM A BRAIN STRUCTURE CALLED THE SUBICULUM WERE DESTROYED USING A NEUROTOXIN, TO DISCONNECT THE NEURAL CIRCUITRY IN THIS MOUSE MODEL. THE RESULT WAS DECREASED A BETA PATHOLOGY IN BRAIN REGIONS ON THE SIDE WHERE THE CIRCUITRY WAS DESTROYED, BUT A BETA PATHOLOGY WAS UNCHANGED ON THE SIDE WHERE THE CIRCUITRY WAS LEFT INTACT. THESE RESULTS SUPPORT THE IDEA THAT A BETA PATHOLOGY IS TRANSMITTED BETWEEN INTERCONNECTED NEURONS IN ALZHEIMER'S DISEASE (GEORGE ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS 2: 17). A STUDY OF PERSONS WHO HAD ATTEMPTED SUICIDE SHOWED THAT NEARLY 60% OF THOSE PERSONS WERE DEFICIENT IN VITAMIN D. THERE WAS ALSO A SIGNIFICANT ASSOCIATION BETWEEN LOW VITAMIN D LEVELS AND HIGH LEVELS OF PRO-INFLAMMATORY CYTOKINES (IL-6 AND IL-1 BETA) IN THEIR BLOOD. ROUTINE CLINICAL TESTING OF VITAMIN D LEVELS AND SUPPLEMENTATION AS NEEDED COULD BE BENEFICIAL IN PATIENTS WITH SUICIDAL SYMPTOMS (GRUDET ET AL., PSYCHONEUROENDOCRINOLOGY 50: 210-219). NEURON GLIAL 2 (NG2) CELLS FORM THE MYELIN SHEATH SURROUNDING NERVES AND SUPPORT NEURONS IN A VARIETY OF WAYS. IN INJURED AREAS OF THE BRAIN, THESE CELLS PROLIFERATE AND INCREASE THE SHEDDING OF THE PROTEOGLYCAN NG2 FROM THEIR CELL SURFACE. THIS ANALYSIS, DONE IN RATS THAT HAD SYSTEMICALLY INDUCED NEUROINFLAMMATION, SHOWED LOWER RATES OF CELL PROLIFERATION AND MORE NG2 IN THE CEREBROSPINAL FLUID. HUMAN NG2 CELLS IN CULTURE EXPOSED TO THE PROINFLAMMATORY CYTOKINES IL-6 AND IL-1 BETA FOR 24 HOURS SHOWED THE SAME EFFECTS. SYSTEMIC INFLAMMATION MAY HAVE PROFOUND EFFECTS ON SPECIFIC CELL POPULATIONS IN THE NERVOUS SYSTEM, AND THESE RESULTS MAY BE IMPORTANT IN STUDIES OF DEPRESSION AND SICKNESS BEHAVIOR (WENNSTROM ET AL., PLOS ONE 9(10): E109387).
FORM 990, PART X, LINE 33 VARI NET ASSETS ARE CONSIDERED ON A CONSOLIDATED BASIS WITH VAN ANDEL INSTITUTE (VAI), VAN ANDEL EDUCATION INSTITUTE (VAEI), AND RELATED PARTIES. ON A CONSOLIDATED BASIS, NET ASSETS ARE $1,207,293,000 PER AUDITED FINANCIAL STATEMENTS. THE NEGATIVE NET ASSET BALANCE AT VARI IS DUE TO VAI FUNDING EXPENSES ON A CASH BASIS AND THE UNREALIZED LOSS RECORDED IN ASSOCIATION WITH THE INTEREST RATE SWAP.
FORM 990, PART IX, COLUMN D FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH DONOR SOLICITATION, GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2013

Additional Data


Software ID:  
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SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBulletAttach to Form 990. MediumBullet See separate instructions.
MediumBullet Information about Schedule R (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047
2013
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Identification of Disregarded Entities Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income


 		(e)
End-of-year assets


 		(f)
Direct controlling
entity
(1) VAI INNOVATIONS LLC
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
52-2000823 		LICENSING INTELLECTUAL PROPERTY OF VARI MI 0 0 VAN ANDEL RESEARCH INSTITUTE
 
(2) VARI INTERNATIONAL
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
26-2615936 		BIOMEDICAL RESEARCH MI -25 0 VAN ANDEL RESEARCH INSTITUTE
 
(3) BOSTWICK EVENT MANAGEMENT
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
52-2000823 		EVENT MANAGEMENT MI 6,317 119,338 VAN ANDEL RESEARCH INSTITUTE
 






Part II
Identification of Related Tax-Exempt Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section


 		(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled entity?
Yes No
(1) VAN ANDEL INSTITUTE

333 BOSTWICK AVENUE NE

GRAND RAPIDS,MI495032518
52-2000820 		SUPPORTING ORGANIZATION FOR VARI AND VAEI MI 501(C)(3) 11C N/A
 
No
(2) VAN ANDEL EDUCATION INSTITUTE

333 BOSTWICK AVENUE NE

GRAND RAPIDS,MI495032518
52-2000824 		OPERATING A SCIENCE EDUCATION PROGRAM MI 501(C)(3) 2 VAN ANDEL INSTITUTE
 
Yes
 
(3) VAN ANDEL INSTITUTE GRADUATE SCHOOL

333 BOSTWICK AVENUE NE

GRAND RAPIDS,ME495032518
20-3340886 		OPERATING A GRADUATE SCHOOL MI 501(C)(3) 2 VAN ANDEL EDUCATION INSTITUTE
 
Yes
 








For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2013
Schedule R (Form 990) 2013
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V-UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No












Part IV
Identification of Related Organizations Taxable as a Corporation or Trust Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.
(a)
Name, address, and EIN of
related organization
 		(b)
Primary activity
 		(c)
Legal
domicile
(state or foreign
country)
 		(d)
Direct controlling
entity
 		(e)
Type of entity
(C corp, S corp,
or trust) 		(f)
Share of total income
 		(g)
Share of end-of-year
assets
 		(h)
Percentage
ownership
 		(i)
Section 512(b)(13) controlled entity?
Yes No












Schedule R (Form 990) 2013
Schedule R (Form 990) 2013
Page 3
Part V
Transactions With Related Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest (ii) annuities (iii) royalties or (iv) rent from a controlled entity . . . . . . . . . . . . . . . . . . . . . . .
1a
Yes
 
b Gift, grant, or capital contribution to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1b
 
No
c Gift, grant, or capital contribution from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1c
Yes
 
d Loans or loan guarantees to or for related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1d
 
No
e Loans or loan guarantees by related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1e
Yes
 
f Dividends from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1f
 
No
g Sale of assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1g
 
No
h Purchase of assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1h
 
No
i Exchange of assets with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . .
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) . . . . . . . . . . . . . . . . . . . .
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) . . . . . . . . . . . . . . . . . . . .
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) . . . . . . . . . . . . . . . . . . . . .
1n
Yes
 
o Sharing of paid employees with related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1o
Yes
 
p Reimbursement paid to related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1p
Yes
 
q Reimbursement paid by related organization(s) for expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1q
Yes
 
r Other transfer of cash or property to related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1r
 
No
s Other transfer of cash or property from related organization(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1s
 
No
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of related organization 		(b)
Transaction
type (a-s) 		(c)
Amount involved 		(d)
Method of determining amount involved
(1) VAN ANDEL INSTITUTE

 C 54,244,758 ACTUAL AMOUNT PAID
(2) VAN ANDEL INSTITUTE

 E 36,310,000 TOTAL RECORDED
(3) VAN ANDEL INSTITUTE

 N 315,668 ALLOCATION BASED ON SQ. FOOTAGE
(4) VAN ANDEL INSTITUTE

 P 321,710 ACTUAL AMOUNT PAID
(5) VAN ANDEL INSTITUTE

 N 173,843 ALLOCATION BASED ON EFFORT
(6) VAN ANDEL INSTITUTE

 O 1,167,918 ALLOCATION BASED ON EFFORT
(7) VAN ANDEL EDUCATION INSTITUTE

 P 74,222 ACTUAL AMOUNT PAID
(8) VAN ANDEL EDUCATION INSTITUTE

 Q 1,183,125 ACTUAL AMOUNT RECEIVED
(9) VAN ANDEL EDUCATION INSTITUTE

 O 72,433 APPORTIONED FY14 COMPENSATION
(10) VAN ANDEL EDUCATION INSTITUTE

 N 40,815 ALLOCATION BASED ON EFFORT
(11) VAN ANDEL EDUCATION INSTITUTE

 O 274,207 ALLOCATION BASED ON EFFORT
(12) VAN ANDEL INSTITUTE GRADUATE SCHOOL

 N 19,652 ALLOCATION BASED ON EFFORT
(13) VAN ANDEL INSTITUTE GRADUATE SCHOOL

 N 177,563 ALLOCATION BASED ON SQ. FOOTAGE
(14) VAN ANDEL INSTITUTE GRADUATE SCHOOL

 Q 176,613 ACTUAL AMOUNT RECEIVED
(15) VAN ANDEL INSTITUTE GRADUATE SCHOOL

 O 132,025 ALLOCATION BASED ON EFFORT
(16) VAN ANDEL INSTITUTE

 Q 4,898,189 ACTUAL AMOUNT PAID
Schedule R (Form 990) 2013
Schedule R (Form 990) 2013
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income (related, unrelated, excluded from tax under sections 512-514)

(e)
Are all partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V?UBI
amount in box 20
of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2013
Schedule R (Form 990) 2013
Page 5
Part VII
Supplemental Information
Provide additional information for responses to questions on Schedule R (see instructions).
Return Reference Explanation
Schedule R (Form 990) 2013
Additional Data


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