Attach to Form 990 or Form 990-EZ.
Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
| (i)Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 9 above or IRC section (see instructions)) | (iv) Is the organization listed in your governing document? | (v) Amount of monetary support (see instructions) | (vi) Amount of other support (see instructions) | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
| Total | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2010 | (b) 2011 | (c) 2012 | (d) 2013 | (e) 2014 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .... | 37,417,260 | 33,572,100 | 39,413,484 | 41,532,901 | 47,770,745 | 199,706,490 |
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....... | 0 | |||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | 0 | |||||
| 4 | Total. Add lines 1 through 3 | 37,417,260 | 33,572,100 | 39,413,484 | 41,532,901 | 47,770,745 | 199,706,490 |
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. | 354,827 | |||||
| 6 | Public support. Subtract line 5 from line 4. | 199,351,663 | |||||
Calendar year
(or fiscal year beginning in) ![]() |
(a) 2010 | (b) 2011 | (c) 2012 | (d) 2013 | (e) 2014 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | 37,417,260 | 33,572,100 | 39,413,484 | 41,532,901 | 47,770,745 | 199,706,490 |
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | 11,313,782 | 15,165,483 | 16,370,797 | 14,057,593 | 3,644,064 | 60,551,719 |
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. | 1,457,363 | 1,457,363 | ||||
| 11 | Total support Add lines 7 through 10. | 261,715,572 | |||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2010 | (b) 2011 | (c) 2012 | (d) 2013 | (e) 2014 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose...... | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513.. | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 6 | Total. Add lines 1 through 5. | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons... | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support (Subtract line 7c from line 6.) | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2010 | (b) 2011 | (c) 2012 | (d) 2013 | (e) 2014 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||
| Section A - Adjusted Net Income | (A) Prior Year |
(B) Current Year (optional) |
||||
| 1 | Net short-term capital gain | 1 | ||||
| 2 | Recoveries of prior-year distributions | 2 | ||||
| 3 | Other gross income (see instructions) | 3 | ||||
| 4 | Add lines 1 through 3 | 4 | ||||
| 5 | Depreciation and depletion | 5 | ||||
| 6 | Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) | 6 | ||||
| 7 | Other expenses (see instructions) | 7 | ||||
| 8 | Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) | 8 | ||||
| Section B - Minimum Asset Amount | (A) Prior Year |
(B) Current Year (optional) |
||||
| 1 | Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): | 1 | ||||
| a | Average monthly value of securities | 1a | ||||
| b | Average monthly cash balances | 1b | ||||
| c | Fair market value of other non-exempt-use assets | 1c | ||||
| d | Total (add lines 1a, 1b, and 1c) | 1d | ||||
| e | Discount claimed for blockage or other factors (explain in detail in Part VI): | |||||
| 2 | Acquisition indebtedness applicable to non-exempt use assets | 2 | ||||
| 3 | Subtract line 2 from line 1d | 3 | ||||
| 4 | Cash deemed held for exempt use. Enter 1-1/2% of line 3 (for greater amount, see instructions). | 4 | ||||
| 5 | Net value of non-exempt-use assets (subtract line 4 from line 3) | 5 | ||||
| 6 | Multiply line 5 by .035 | 6 | ||||
| 7 | Recoveries of prior-year distributions | 7 | ||||
| 8 | Minimum Asset Amount (add line 7 to line 6) | 8 | ||||
| Section C - Distributable Amount | Current Year | |||||
| 1 | Adjusted net income for prior year (from Section A, line 8, Column A) | 1 | ||||
| 2 | Enter 85% of line 1 | 2 | ||||
| 3 | Minimum asset amount for prior year (from Section B, line 8, Column A) | 3 | ||||
| 4 | Enter greater of line 2 or line 3 | 4 | ||||
| 5 | Income tax imposed in prior year | 5 | ||||
| 6 | Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) | 6 | ||||
| 7 | Check here if the current year is the organization's first as a non-functionally-integrated Type III supporting organization (see instructions) | |||||
| Section D - Distributions | Current Year | |
|---|---|---|
| 1 Amounts paid to supported organizations to accomplish exempt purposes | ||
|
2
Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity |
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| 3 Administrative expenses paid to accomplish exempt purposes of supported organizations | ||
| 4 Amounts paid to acquire exempt-use assets | ||
| 5 Qualified set-aside amounts (prior IRS approval required) | ||
| 6 Other distributions (describe in Part VI). See instructions | ||
| 7Total annual distributions. Add lines 1 through 6. | ||
|
8
Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions |
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| 9 Distributable amount for 2014 from Section C, line 6 | ||
| 10 Line 8 amount divided by Line 9 amount | ||
| Section E - Distribution Allocations (see instructions) |
(i) Excess Distributions |
(ii) Underdistributions Pre-2014 |
(iii) Distributable Amount for 2014 |
|
|---|---|---|---|---|
|
1
Distributable amount for 2014 from Section C, line 6 |
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|
2
Underdistributions, if any, for years prior to 2014 (reasonable cause required--see instructions) |
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| 3 Excess distributions carryover, if any, to 2014: | ||||
| a From 2009.......X | ||||
| b From 2010.......X | ||||
| c From 2011.......X | ||||
| d From 2012.......X | ||||
| e From 2013....... | ||||
| fTotal of lines 3a through e | ||||
| g Applied to underdistributions of prior years | ||||
| h Applied to 2014 distributable amount | ||||
|
i
Carryover from 2009 not applied (see instructions) |
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| j Remainder. Subtract lines 3g, 3h, and 3i from 3f. | ||||
| 4Distributions for 2014 from Section D, line 7: | ||||
| $ | ||||
| a Applied to underdistributions of prior years | ||||
| b Applied to 2014 distributable amount | ||||
| c Remainder. Subtract lines 4a and 4b from 4. | ||||
|
5
Remaining underdistributions for years prior to 2014, if any. Subtract lines 3g and 4a from line 2 (if amount greater than zero, see instructions) |
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|
6
Remaining underdistributions for 2014. Subtract lines 3h and 4b from line 1 (if amount greater than zero, see instructions) |
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|
7 Excess distributions carryover to 2015. Add lines 3j and 4c. |
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| 8 Breakdown of line 7: | ||||
| a From 2010.......X | ||||
| b From 2011.......X | ||||
| c From 2012.......X | ||||
| d From 2013....... | ||||
| e From 2014....... | ||||
| Facts And Circumstances Test |
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| Return Reference | Explanation |
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| Software ID: | |
| Software Version: |
Attach to Form 990 or 990-EZ.
Information about Schedule O (Form 990 or 990-EZ) and its instructions is at| Return Reference | Explanation |
|---|---|
| FORM 990, PART I, LINE 1 & PART III, LINE 1: | THE MASSACHUSETTS EYE AND EAR INFIRMARY ("THE INFIRMARY") IS A NOT-FOR-PROFIT TEACHING HOSPITAL CONDUCTING PATIENT CARE AND RESEARCH. THE INFIRMARY IS A TEACHING HOSPITAL OF HARVARD MEDICAL SCHOOL AND AN INTERNATIONAL CENTER FOR RESEARCH. IT HAS THE MOST COMPETITIVE PROGRAM IN THE COUNTRY FOR EYE, EAR, NOSE, AND THROAT RESIDENCY TRAINING AND THE WORLD'S LARGEST OPHTHALMIC FELLOWSHIP PROGRAM. IT IS PART OF A SYSTEM OF RELATED ENTITIES THAT PROVIDE SPECIALIZED MEDICAL CARE COLLECTIVELY KNOWN AS "MASSACHUSETTS EYE AND EAR INFIRMARY" ("MEEI"). |
| FORM 990, PART III, LINE 4A: | Massachusetts Eye and Ear is a specialty hospital dedicated to excellence in the care of disorders that affect the eye, ear, nose, throat and adjacent regions of the head and neck. 2015 was an exceptional year : U.S. News & World Report ranked Mass. Eye and Ear #1 in the nation; growth throughout seventeen clinical locations; advancements in research; commitment to community; and the launch of two major technology transitions, PeopleSoft, which is the system Mass. Eye and Ear will use for all enterprise resource planning (payroll, general ledger, HR) and Epic, our new, unified patient care system. They are both considered the premier products in their field and have an impact on virtually every person in the Mass. Eye and Ear community. Research Ophthalmology Age-related Macular Degeneration Center of Excellence Preventing Vision Loss through Neuroprotection Researchers are investigating novel neuroprotection strategies for AMD, focusing on understanding the multiple pathways that lead to photoreceptor cell death in the retina and associated vision loss. While anti-angiogenesis treatments can be beneficial for patients with wet AMD, neuroprotection offers a potentially complementary treatment approach in cases where neuron loss continues to progress. Investigators in the Mass. Eye and Ear Angiogenesis Laboratory have identified the mode of death of cone cell photoreceptors in an animal model of retinitis pigmentosa. Demetrios Vavvas, MD, PhD; Joan W. Miller, MD; and colleagues have further demonstrated that receptor-interacting protein kinase-mediated program necrosis is a key mediator of photoreceptor cell loss and damage in animal models of inherited retinal degenerations and dry AMD. Kip Connor, PhD; Deeba Husain, MD; and other vision researchers at Mass. Eye and Ear found a significant increase in the immune system's alternative complement pathway following retinal detachment. Healthy photoreceptors have proteins that normally protect them from complement-mediated cell death. However, injured photoreceptors lose these proteins, and are selectively targeted by the alternative complement pathway, resulting in early photoreceptor cell death. Researchers were able to protect photoreceptors from cell death by blocking the alternative complement pathway. Inflammation and the Development of Dry AMD A collaborative effort among the laboratories of Patricia A. D'Amore, PhD, MBA; Bruce Ksander, PhD; Meredith Gregory-Ksander, PhD; and Kameran Lashkari, MD, at Schepens Eye Research Institute of Mass. Eye and Ear suggests that the inflammasome plays a role in the development of dry AMD. Retinal tissue from human donor eyes with AMD showed expression of components of the inflammasome, whereas retinal tissue from age-matched controls showed none. The inflammasome may represent a new target for the prevention or attenuation of AMD. Cornea Center of Excellence Limbal Stem Cell Deficiency Project Ula Jurkunas, MD; Ahmad Kheirkhah, MD; Kishore Reddy, PhD; Reza Dana, MD, MSc, MPH; and colleagues from the Center for Human Cell Therapy at Boston Children's Hospital, are studying a new method for growing cells from a patient's healthy eye and transplanting them onto the diseased eye. If successful, this intervention could offer hope for a significant number of blind patients worldwide. Researchers in other countries are investigating similar transplantation methods, but are using animal-derived cells. Aside from this Phase I trial, there are no known clinical trials in the United States studying a human-derived cell intervention. New Treatments for Dry Eye and Ocular Surface Disease Reza Dana, MD, MSc, MPH, and colleagues are participating in a multicenter study to determine the efficacy of fish oil supplements containing omega-3 fatty acids for dry eye. If proven to be effective, this could be this could be a new, safe, over-the-counter therapy for patients with dry eye disease. Also, Mass. Eye and Ear has teamed up with Rigel Pharmaceuticals to evaluate the efficacy of a novel eye drop to treat ocular surface disease in patients with ocular graft-versus-host disease, a common and serious complication in stem cell and bone marrow transplant recipients. Another study has Mass. Eye and Ear investigators teaming with Domp, a biopharmaceutical company, to test the efficacy of nerve growth factor in patients with non-healing corneal defects. Innovative Medical Therapies: From Eye Drops to Drug-Eluting Contact Lenses. In collaboration with colleagues at Boston Children's Hospital and Massachusetts Institute of Technology, Joseph Ciolino, MD, developed a drug-eluting contact lens that can deliver various pharmaceutical agents at a sustained therapeutic rate daily for a full month. Already, he and colleagues have successfully used the lens to deliver latanoprost, a common glaucoma medication. While still in development, this contact lens has the potential to benefit a diverse patient population. In support of these efforts, the Department of Defense awarded Dr. Ciolino and colleagues nearly $1 million in 2014. Glaucoma Center of Excellence Imaging in Three Dimensions Teresa Chen, MD, and Lucy Shen, MD, of Mass. Eye and Ear are advancing imaging techniques to aid in the early diagnosis and monitoring of patients with glaucoma and other retinal diseases. Dr. Chen focuses her research on 3D imaging of the eye using spectral domain optical coherence tomography (SD-OCT) and swept source imaging. Along with colleagues in the Glaucoma Center of Excellence and investigators at Massachusetts General Hospital, she was the first to image the human eye in vivo with video-rate SD-OCT, a widely used imaging modality for the care of glaucoma patients. With SD-OCT, ultra-high resolution 3D video imaging of the optic nerve and the retina is possible. Dr. Shen conducted a research study that imaged the glaucomatous optic nerve using 3D swept-source optical coherence tomography (SS-OCT). Since then, 3D images of more than 1,000 patients have been captured using this imaging technology. These images are playing a key role in developing newer methods of detecting microscopic changes in the optic nerve and surrounding nerve tissues, which are affected in glaucoma disease. New Insights into Exfoliation Glaucoma Exfoliation glaucoma is an age-related systemic disease that manifests itself primary in the eyes. As little is known about its cause, increased attention has been given to understanding the role of the environment, diet, and lifestyle in this disorder. Louis Pasquale, MD, and Janey Wiggs, MD, PhD, of Mass. Eye and Ear, along with colleagues at Brigham and Women's Hospital, found that living in the middle or southern United States was associated with a decreased risk of exfoliation glaucoma when compared to the northern states. In another study, researchers found a link between caffeinated coffee consumption and the development of exfoliation glaucoma. Diabetic Eye Disease Center of Excellence Understanding Diabetic Retinopathy in African Americans Diabetes is one of the most serious health problems that the African American community faces today. By drawing patients from the Jackson Heart Study patient population (African Americans with cardiovascular disease), Lucia Sobrin, MD, MPH, and colleagues are investigating the genetic profiles of patients who develop retinopathy with those who do not develop the disease. Understanding these genetic factors may lead to insights about novel molecular pathways that are involved in the advancement of diabetic retinopathy and consequently lead to the identification of new treatment targets. Identifying non-genetic risk factors associated with progression is also important because this knowledge can be used to counsel patients on lifestyle changes (smoking, diet, etc.) that may lower their risks of developing the late stages of diabetic retinopathy. Mobility Enhancement and Vision Rehabilitation Center of Excellence Prism Glasses for Hemianopia Alex Bowers, PhD, and colleagues published the first multicenter randomized controlled clinical trial of a prismatic correction for hemianopia. This study represents a major step forward in the field and establishes an evidence base for the efficacy of peripheral prism glasses for hemianopia. The prism device itself was invented by Eli Peli, MSc, OD, at Schepens Eye Research Institute of Mass. Eye and Ear, where many early clinical trials were conducted. Video Games Teach Navigational Skills To better understand the brain's role in wayfinding, Lotfi Merabet, OD, PhD, MPH, and colleagues used functional neuroimaging to show that the region of the brain associated with navigation skills, independence, and visual information becomes activated during gaming. This suggests that information learned through video games translates into interactive "mind maps" in the gamer's brain that can be later called upon for way finding. Ocular Oncology Center of Excellence Limitations of Metformin |
| Kinga Bujakowska, MD, and colleagues demonstrated that metformin, an | anti-diabetic drug, inhibited the in vitro proliferation of retinoblastoma cells at levels well above those tolerated in vivo. This suggests that metformin's potential anticancer effects, observed in epidemiological studies, may be limited to specific tumor types, and/or related to indirect mechanisms not observed under laboratory conditions. Verteporfin, Possible Adjuvant for Retinoblastoma Joan W. Miller, MD; Evangelos Gragoudas, MD; and Demetrios Vavvas, MD, PhD, demonstrated a novel role of the YAP-TEAD pathway in retinoblastoma, as well as the therapeutic potential of verteporfin as an adjunctive therapy when treating patients with retinoblastoma. Verteporfin without light activation was found to be a potent inhibitor of retinoblastoma cell growth, disrupting proto-oncogenes downstream of the YAP-TEAD signaling pathway and downregulating the pluripotent marker OCT4. Infectious Disease Institute (IDI) New Diagnostic Tests Michael Gilmore, PhD; James Chodosh, MD, MPH; Marlene Durand, MD; Lucia Sobrin, MD, MPH; Suzanne Freitag, MD; Lucy Young, MD, PhD; and Wolfgang Haas, PhD, have begun to develop and implement new diagnostic tests to detect difficult-to-diagnose infections of the eye. As current methods require days to yield results, the long-term goal is to develop new rapid diagnostic technologies that can detect a range of pathogens within hours. In collaboration with the clinical microbiology laboratory, clinicians are working to develop, and receive clinical laboratory improvement amendments (CLIA) approval, for state-of-the-art rapid PCR diagnosis of viral infections of the eye to speed patient diagnosis and treatment. Ocular Genomics Institute (OGI) Researchers Resurrect Ancient Viruses in Hopes of Improving Gene Therapy Luk Vandenberghe and colleagues have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina. This approach, published July 30, 2015 in Cell Reports, could be used to design a new class of genetic drugs that are safer and more potent than those currently available. Dr. Vandenberghe and his colleagues hope to use they knowledge gained in this study to design next-generation viruses for use as vectors in gene therapy." EFEMP1 Gene Mutation in Doyne Honeycomb Retinal Dystrophy/Malattia Leventinese Eric Pierce, MD, PhD; Donita Garland, PhD; and colleagues used proteomic analyses to identify the proteins present in the basal deposits of Efemp1-R345W mice-a model of Doyne honeycomb retinal dystrophy/malattia Leventinese. In humans, this inherited macular degeneration is caused by mutations in the EFEMP1 gene, which encodes an extracellular matrix protein. Researchers showed that the basal deposits are composed of normal extracellular matrix components that are present in abnormal amounts. The proteomic analyses also suggest that the altered extracellular matrix stimulates a local immune response, including activation of the complement system. Ocular Regenerative Medicine Institute (ORMI) First to Regrow Fully Functional Human Corneas in Mice Bruce Ksander, PhD, and post-doctoral fellow Evi Kolovou, MD, as well as other ORMI members - James Zieske, PhD, and Meredith Gregory-Ksander, PhD - identified ABCB5 as a marker of limbal stem cells, which are necessary for corneal development and repair. As a result, Drs. Ksander and Kolovou were able to use antibodies detecting ABCB5 to target the stem cells in tissue from deceased human donors, and use them to regrow anatomically correct, fully functional human corneas in mice. The ability to prospectively identify and isolate limbal stem cells will greatly enhance the success of corneal regeneration in patients with a limbal stem cell deficiency. Otolaryngology Basic Science Non-canonical pathway from cochlea to brain signals tissue-damaging noise A team of researchers, including M. Charles Liberman, Ph.D., published a paper showing that the unmyelinated fibers in the cochlear nerve, whose function has remained unknown, respond to hair cell damage in the inner ear and thus likely constitute the nociceptive pathway of the auditory periphery responsible for signaling auditory pain. This discovery could help lead to the development of therapies for hyperacusis, the debilitating hypersensitivity to moderate level sounds that sometimes occurs following acoustic injury. Flores EN, Duggan A, Madathany T, Hogan AK, Mrquez FG, Kumar G, Seal RP, Edwards RH, Liberman MC, Garca-Aoveros J. A non-canonical pathway from cochlea to brain signals tissue-damaging noise. Curr Biol. 2015 Mar 2;25(5):606-12. New system could be used to treat deafness, other genetic conditions A team of researchers including Zheng-Yi Chen, Ph.D., developed a system that uses commercially available molecules, cationic lipids, to efficiently deliver genome-editing proteins into cells, and have even demonstrated that the technology can be used to perform genome editing in living animals. They believe that delivering genome-editing proteins into cells could offer hope to patients suffering from a host of conditions, including certain diseases of the eye, ear, liver, muscles and blood. Dr. Chen's team will use the newly developed system to modify genes in specialized hair cells in the inner ears of mice to pursue new protein-based therapies for hearing loss. Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nat Biotechnol. 2015 Jan;33(1):73-80. Researchers find salicylates, a class of NSAIDs, stop growth of vestibular schwannomas A team of researchers including Konstantina Stankovic, M.D., Ph.D., FACS, demonstrated that salicylates, a class of non-steroidal inflammatory drugs (NSAIDs), reduced the proliferation and viability of cultured vestibular schwannoma cells that cause a sometimes lethal intracranial tumor that typically causes hearing loss and tinnitus. Dilwali S, Kao SY, Fujita T, Landegger LD, Stankovic KM. Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas. Transl Res. 2015 Jan 7. P-glycoprotein inhibitor may lead to new therapies for chronic rhinosinusitis with nasal polyps Chronic rhinosinusitis with nasal polyps is a lifelong inflammatory disease of the sinuses. The causes of this disease are poorly understood and, consequently, treatment options are limited to steroids, which have many negative side effects. Benjamin S. Bleier, M.D., and members of his laboratory have discovered that a cellular pump, P-glycoprotein, is overactive in these patients and may be responsible for the high levels of inflammation seen in these patients. Dr. Bleier demonstrated that Verapamil, an inhibitor of P-glycoprotein, can block the release of some of the cytokines specifically involved in polyp-related inflammation. These results not only point the way towards a better understanding of what causes chronic rhinosinusitis with nasal polyps, but they also open the door to new therapeutic options. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan;5(1):10-3. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice A team of researchers from Mass. Eye and Ear/Harvard Medical School, including Konstantina M. Stankovic, M.D., Ph.D., with collaborators from the University of Copenhagen, has shed further light on the acute loss of synapses on sensory inner hair cells, which contributes to hidden hearing loss. The researchers explored whether cochlear synaptopathy followed by neuropathy occurred after noise exposure in pubescence. They also defined the noise levels at which neuropathic damage occurs, and compared those levels to non-neuropathic noise levels. The data demonstrated a fine line between neuropathic and non-neuropathic noise levels associated with temporary threshold shift in the pubescent cochlea. Jensen JB, Lysaght AC, Liberman MC, Qvortrup K, Stankovic KM. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice. PLoS One. 2015 May 8;10(5):e0125160. Delivery of bisphosphonates to the inner ear Researchers from Mass. Eye and Ear/Harvard Medical School, including David H. Jung, M.D., Ph.D., found that bisphosphonates, potent inhibitors of bone remodeling, can be delivered directly to the mammalian cochlea without damaging the inner ear. This is potentially important for the treatment of otosclerosis, a bone metabolism disorder that results in hearing loss. The work also contributes to an understanding of where drugs go when they are delivered to the cochlea; therefore, the paper has broader implications for treatment of other ear diseases. |
| Kang WS, Sun S, Nguyen K, Kashemirov B, McKenna CE, Hacking SA, Quesnel | AM, Sewell WF, McKenna MJ, Jung DH. Non-ototoxic local delivery of bisphosphonate to the mammalian cochlea. Otol Neurotol. 2015 Jul;36(6):953-60. Researchers Develop Techniques to Bypass Blood-Brain Barrier, Deliver Drugs to Brain and Nervous System A team of researchers from Mass. Eye and Ear/Harvard Medical, including Benjamin S. Bleier, M.D., using a neuroprotective model, successfully prevented the development of Parkinson's disease in a mouse model using nasal mucosal grafting to deliver glial derived neurotrophic factor (GDNF)-a known therapeutic protein shown to delay or even reverse disease progression in Parkinson's disease-to the brain and central nervous system. They showed through behavioral and histological data that their delivery method was equivalent to direct injection of GDNF-the current gold standard for delivering this drug in Parkinson's disease-in diffusing drugs to the brain. Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery. 2016 Mar;78(3):448-57. Bioengineering Researchers demonstrate functionality of key component in the development of an implantable inner ear drug delivery device A team of researchers from Draper continues their collaboration with faculty at Mass. Eye and Ear, including Sharon G. Kujawa, Ph.D., Michael J. McKenna, M.D., and William F. Sewell, Ph.D., to develop an implantable drug delivery device for the treatment of sensorineural hearing loss. The device addresses one of the most significant challenges in restoring hearing, the blood-cochlear barrier, by delivering precise quantities of one or more drugs in a timed sequence to the inner ear to regrow sensory cells. A recent study demonstrated functionality of a key component of the device-the micropump delivering drugs to the cochlea. Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform. Biomed Microdevices. 2015 Apr;17(2):9923. Light-based activation of the auditory system Elliott D. Kozin, M.D., A. Ed Hight, M.S., M. Christian Brown, Ph.D., Daniel J. Lee, M.D., and colleagues from MIT have demonstrated the ability to stimulate the auditory system with light. They found in a murine auditory brainstem implant model that the central auditory pathway could be sensitized to light by delivery of novel light sensitive proteins called "opsins." Prior reports by this group demonstrated that older generations of opsins may be too slow to encode speech information. However, a new opsin, developed by collaborators at MIT, called Chronos, may have the kinetics fast enough to form the basis of a light-based auditory implant. These findings have implications for the future auditory neuroprosthetics, as well as improved outcomes in patients with cochlear and auditory brainstem implants. Hight AE, Kozin ED, Darrow K, Lehmann A, Boyden E, Brown MC, Lee DJ. Superior temporal resolution of chronos versus channelrhodopsin-2 in an optogenetic model of the auditory brainstem implant. Hear Res. 2015 Apr;322:235-41. Clinical Practice Disparities in emergency department utilization for acute sinusitis A team of rhinologists, including senior author Ahmad R. Sedaghat, M.D., Ph.D., recently published a series of assessments related to emergency department utilization for acute sinusitis. In this study, researchers have shown that hundreds of thousands of individuals continue to utilize emergency departments annually for uncomplicated acute sinusitis-a non-urgent condition that can be appropriately managed in outpatient clinics-and also showed a correlation with Medicaid insurance. Though previous studies have suggested that individuals with Medicaid are less likely to be satisfied with the quality of their primary care encounters and have more difficulty getting access to clinic appointments in a timely manner, this study found that there were no disparities in quality of acute sinusitis primary care for patients with Medicaid. In fact, physicians were found to spend more time with Medicaid patients compared to patients with private insurance. Scangas GA, Ishman SL, Bergmark RW, Cunningham MJ, Sedaghat AR. Emergency department presentation for uncomplicated acute rhinosinusitis is associated with poor access to health care. Laryngoscope. Laryngoscope. 2015 Oct;125(10):2253-8. Bergmark RW, Ishman SL, Scangas GA, Cunningham MJ, Sedaghat AR. Insurance status and quality of outpatient care for uncomplicated acute rhinosinusitis. JAMA Otolaryngol Head Neck Surg. 2015 Jun;141(6):505-11 Correction of the alar base in patients with flaccid facial paralysis Faculty from the Facial Nerve Center at Mass. Eye and Ear, including Tessa A. Hadlock, M.D., and Robin W. Lindsay, M.D., prospectively studied the effect of placement of a fascia lata sling placement for correction of external nasal valve compromise in 68 patients with flaccid facial paralysis, utilizing a validated disease specific quality of life outcome survey, the Nasal Obstruction Symptom Evaluation (NOSE) scale. Ratings were ascertained preoperatively and postoperatively. Sixty patients completed a NOSE survey prior to surgical intervention and 40 completed the survey after intervention. There was a statistically significant difference in NOSE scores after fascia lata sling (Wilcoxin signed-rank test, p<0.001). All patients had improvement in their nasal obstruction, which persisted uniformly in follow-up. Lindsay RW, Bhama P, Hohman M, Hadlock TA. Prospective evaluation of quality-of-life improvement after correction of the alar base in the flaccidly paralyzed face. JAMA Facial Plast Surg. 2015 Mar 1;17(2):108-12. Use of intraoperative CT scanning for maxillofacial reconstructive surgery An important part of intraoperative decision making, intraoperative computed tomography (CT) provides surgeons with real-time feedback during maxillofacial trauma and reconstructive surgery. A team of researchers including David A. Shaye, M.D., recently published a study evaluating a variety of factors, including the time needed to perform intraoperative CT scans during maxillofacial surgery and to identify the characteristics of cases that required intraoperative revision based on the results of an intraoperative CT scan. In the study, which reviewed 38 cases, the authors concluded that current intraoperative CT scanning techniques are rapid, averaging 14.5 minutes per case, and that intraoperative revisions were most common in complex cases. They recommend that surgeons use intraoperative CT imaging for maxillofacial reconstruction, especially in complex procedures. Shaye DA, Tollefson TT, Strong EB. Use of intraoperative computed tomography for maxillofacial reconstructive surgery. JAMA Facial Plast Surg. 2015 Jan 8. Outcomes in professional voice artists undergoing thyroidectomy A team of researchers including Ramon A. Franco, M.D., Gregory W. Randolph, M.D., and Phillip Song, M.D., published a quantitative analysis of pre- and postoperative neural-monitored thyroid surgery voice outcomes in a unique series of professional singers/voice users. Utilizing three validated vocal instruments, the Voice Handicap Index (VHI), the Singing Voice Handicap Index (SVHI) and the Evaluation of Ability to Sing Easily (EASE), researchers surveyed the outcomes of 27 vocal professionals undergoing thyroidectomy with the assistance of nerve monitoring technology. They also studied objective outcome measures such as final intraoperative EMG amplitude, the time to return to performance and vocal parameters affected. The authors concluded that with nerve monitoring technology, thyroidectomy-including those for thyroid malignancy-is safe in professional voice users, showing that there were no changes in three different voice/singing instruments and that 100 percent returned to performance. Randolph G, Sritharan N, Song P, Franco R, Kamani D, Woodson G. Thyroidectomy in the professional singer-neural monitored surgical outcomes. Thyroid. 2015 Mar 19. |
| Voice outcomes after total laryngopharyngectomy reconstruction | A team from Mass. Eye and Ear/Harvard Medical School, including Daniel G. Deschler, M.D., FACS, analyzed voice-related outcomes of more than 40 cases of reconstruction after total laryngectomy or total laryngopharyngectomy-the most thorough and rigorous study of tracheoesophageal voice in reconstructed patients to date. Using a strict protocol developed by this group, subjective and objective speech analysis was combined with three quality of life assessments to demonstrate that although speech in reconstructed patients was inferior to speech in patients who did not require reconstruction, reconstructed patient speech was effective and dependable. The study also demonstrated that speech was not significantly different for patients reconstructed with the radial forearm free flap compared to patients reconstructed with the jejunal free flap. Deschler DG, Herr MW, Kmiecik JR, Sethi R, Bunting G. Tracheoesophageal voice after total laryngopharyngectomy reconstruction: Jejunum versus radial forearm free flap. Laryngoscope. 2015 Jul 21. Emergency department utilization for sinus disease Emergency department (ED) utilization for conditions that can be readily treated at primary care offices is a source of considerable, unnecessary healthcare expenditure. Unnecessary ED utilization can reflect problems with primary care physician access, quality of care, treatment patterns, patient symptoms, or other factors. Researchers from Mass. Eye and Ear/Harvard Medical School, including Ahmad R. Sedaghat, M.D., Ph.D., have used uncomplicated acute rhinosinusitis (ARS) as a paradigm for a common condition that is most appropriately treated in the primary care setting. They previously showed that individuals with Medicaid and the uninsured are disproportionately more likely to use the ED for uncomplicated ARS. They subsequently found evidence that ED use for uncomplicated ARS by Medicaid patients may be partially related to poor access to primary care providers while ED use by the uninsured may be related to the greater severity of their ARS symptomatology. Bergmark RW, Ishman SL, Scangas GA, Cunningham MJ, Sedaghat AR. Socioeconomic determinants of overnight and weekend emergency department use for acute rhinosinusitis. Laryngoscope. 2015 May 27. Radiology Educational Highlights: The radiologists wrote or participated in 40 papers including: Boes AD, Caruso P, Duhaime AC, Fischl B. FreeSurfer is useful for early detection of Rasmussen's encephalitis prior to obvious atrophy. Dev Med Child Neurol. 2015 July 15. Cohen AR, Caruso P, Duhaime AC, Klig JE. Feasibility of "rapid" magnetic resonance imaging in pediatric acute head injury. Am J Emerg Med. 2015 Jul;33(7):887-90. Kolodny E, Fellgiebel A, Hilz MJ, Sims K, Caruso P, Phan TG, Politei J, Manara R, Burlina A. Cerebrovascular involvement in Fabry disease: Current status of knowledge. Stroke. 2015 Jan;46(1):302-13. Diercks GR, Cunnane MB, Hartnick CJ. Laryngeal mask airway may result in false negative imaging for carotid medicalization: A case report. Int J Pediatr Otorhinolaryngol. 2015 Oct 13. Freitag SK, Cunnane MB, Yoon MK, Barnes JA, Winkfield KM, Sohani AR. Case records of the Massachusetts General Hospital-Case 18-2015: A 41 y/o woman with decreased vision in the left eye and diplopia. N Engl J Med. 2015 Jun 11;372(24):2337-45. Noij KS, Remenschneider AK, Kozin ED, Puram S, Herrmann B, Cohen M, Cunnane MB, Lee DJ. Direct parasagittal magnetic resonance imaging of the internal auditory canal to determine cochlear or auditory brainstem implant candidacy in children. Laryngoscope. 2015 Oct;125(10):2382-5. Curtin HD. Imaging of conductive hearing loss with a normal tympanic membrane. Am J Roentgenol. 2015 Oct 22:1-8. Quesnel AM, Nadol JB, Nielsen GP, Curtin HD, Lesperance MM. Temporal bone histopathology in NOG-symphalangism spectrum disorder. Otol Neurotol. 2015 Oct. 12. Raghavan D, Lee TC, Curtin HD. Cholesterol granuloma of the petrous apex: A 5 year review of radiology reports with follow-up of progression and treatment. J Neurol Surg B Skull Base. 2015 Aug:76(4):266-71. Juliano AF, Ginat DT, Moonis G. Imaging review of the temporal bone: Part II, traumatic, postoperative and noninflammatory nonneoplastic conditions. Radiol. 2015 Sep;276(3):655-72. Ho ML, Juliano AF, Eisenberg RL, Moonis G. Anatomy and pathology of the facial nerve. Am J Roentgenol. 2015 Jun;204(6):W612-9. Ochoa EM, Juliano AF, Curtin HD. Interior displacement of the lower belly of the lateral pterygoid muscle: A sign of temporomandibular joint lesions. J Comput Assist Tomogr. 2015 May-Jun;39(3):340-2. Grob SR, Jakobiec FA, Rashid A, MacIntosh P, Kelly H, Fay A. Pediatric optic nerve meningioma: Diagnostic and therapeutic challenges. Ophthal Plast Reconstr Surg. 2015 Jan. 12. Lookabaugh S, Kelly H, Carter MS, Niesten ME, McKenna MJ, Curtin HD, Lee DJ. Radiologic classification of superior canal dehiscence: Implications for surgical repair. Otol Neurotol. 2015 Jan;36(1):118-25. FORM 990, PART III, LINE 4B: Education Academic Programs Ophthalmology -24 Residents -22 Clinical Fellows -119 Research Fellows -Two new clinical fellowships have been initiated: Medical Retina (Directors: Drs. Magda Krzystolik and Paul Greenberg), and Anterior Segment (Director: Dr. Kathryn Hatch) Otolaryngology -18 Residents -11 Clinical Fellows -55 Research Fellows -2 Research Residents -5 additional PGY-1 residents from surgical programs Educational Highlights Ophthalmology Symposia and Conferences: -Alcon Research Institute Symposium, September 18-19, 2015 -Special Grand Rounds - New England Journal of Medicine Clinicopathologic Conference, September 24, 2015 -Annual Meeting and Alumni Reunion: More than 300 HMS Department of Ophthalmology faculty, alumni, and trainees gathered for a three-day meeting and set of events May 29 - 31, 2015. New Course Uveitis Instruction Course Established in 2015, the Uveitis Instruction Course at Mass. Eye and Ear is a one-day event for ophthalmology residents, fellows, medical students and practicing ophthalmologists from Boston and the surrounding New England area. During the course, participants review the diagnosis and treatment of common uveitis conditions in addition to diagnostic testing, imaging, and treatment approaches to ocular inflammatory diseases. Otolaryngology This year we celebrated the graduation of the Class of 2015 at a June 26th ceremony held in the Meltzer Auditorium at Mass. Eye and Ear. Our outstanding graduates included residents Margaret S. Carter, M.D., Kyle J. Chambers, M.D., Sunshine M. Dwojak, M.D., MPH, Allan C. Lam, M.D., and Matthew C. Mori, M.D. We also celebrated the graduation of six clinical fellows: -Caroline A. Banks, M.D., Facial Plastic and Reconstructive Surgery -Neerav Goyal, M.D., Head and Neck Surgical Oncology/Microvascular -Inna A. Husain, M.D., Laryngology -Rahul Modi, M.D., Thyroid and Parathyroid Surgery -Ahmad R. Sedaghat, M.D., Ph.D., Rhinology -William Yao, M.D., Rhinology Following graduation, we welcomed several new trainees in otolaryngology at Mass. Eye and Ear. The HMS Otolaryngology Residency Program recently received approval from ACGME to accept five residents per year. This represents a permanent increase from our previous agreement to accept classes of four or five residents on alternating years. Therefore, this year, five new residents joined the program, including Vivek Kanumuri, M.D., Ashton Lehmann, M.D., Katie Phillips, M.D., Yen Rin, M.D., Ph.D., and Rosh Sethi, M.D., MPH. We also welcomed two new clinical fellows: -Erez S. Davidi, M.D., Neskey-Coghlan Fellowship in Balance and Vestibular Disorders -Tjoson Tjoa, M.D., Head and Neck/Microvascular In other education news, we continue to enjoy our state-of-the-art Otolaryngology Surgical Training Laboratory and have held several major courses there over the past year, from resident dissection courses to CME courses with international attendees. The first fellow for the Neskey-Coghlan Fellowship for Balance and Vestibular Disorders, a one-year post-residency fellowship program based at Mass. Eye and Ear, was selected in July 2015. Mass. Eye and Ear recently established the Lauer Tinnitus Research Center, a research program dedicated to cultivating a deeper understanding of tinnitus and alleviating the condition through the development and evaluation of both medical and rehabilitative treatments. The Center represents a major investment in tinnitus research from scientists of the Eaton-Peabody Laboratories, including M. Charles Liberman, Ph.D., Jennifer Melcher, Ph.D., Daniel Polley, Ph.D., and Konstantina Stankovics, M.D., Ph.D, FACS. Through the generosity of a grateful patient donor, Mass. Eye and Ear has endowed the annual Saumil N. Merchant, M.D., Lecture in Otolaryngology, to be held every year at the American Otological Society meeting. |
| New Textbook: Christopher J. Hartnick, M.D., authored a new textbook, | Surgical Correction of Pediatric Velopharyngeal Insufficiency, with first author Nikhila Raol, M.D., a clinical fellow in Pediatric Otolaryngology at Mass. Eye and Ear. The book was published by Karger Publishers. FORM 990, PART III, LINE 4C: Clinical Care Ophthalmology -Mass. Eye and Ear is one of the first hospitals in New England to offer the most advanced technology available for cataracts - femtosecond laser-assisted cataract surgery. Originating in Europe and approved by the FDA in 2010, this computer-aided method offers patients a less invasive, more precise approach than traditional cataract surgery. The advanced technology also enables a level of precision not attainable with traditional surgical methods and, for example, can be used to perform capsulotomy, one of the more challenging steps in cataract surgery. Mass. Eye and Ear surgeons, Roberto Pineda II, MD, Sherleen Chen, MD, Kathryn Hatch, MD, and Christian Song, MD, are among a handful of surgeons in the Boston area certified to offer patients this procedure. -Minimally invasive glaucoma surgery (MIGS) is a new procedure used to manage glaucoma. Considered generally safer than traditional glaucoma surgery, MIGS lowers intraocular pressure while limiting surgical manipulation of both the sclera and conjunctiva. As a result, patients undergoing MIGS often recover more quickly. Ambika Hoguet, MD, of Mass. Eye and Ear conducts MIGS on adults with glaucoma, especially those who also need cataract surgery. -Janey Wiggs, MD, PhD, directs the OGI's Clinical Laboratory Improvement Amendments (CLIA) certified service, which offers comprehensive genetic diagnostic testing for inherited eye diseases, including inherited retinal degenerations (IRDs), optic atrophy, strabismus, and glaucoma via the Genetic Eye Disease (GEDi) test. The GEDi test provides a more accurate diagnoses than other testing methods, such as whole-exome sequencing. It has been used to analyze more than 300 samples, including those submitted by investigators at Mass. Eye and Ear and from outside institutions. The enhanced diagnostic capability of the GEDi test may help improve genetic counseling and facilitate the use of focal ocular treatments and therapies, including gene therapies. -Gang Luo, PhD, created the SuperVision+ Goggles app to provide a low cost solution for head mounted vision enhancement devices for the visually impaired. The free app for iPhones (iOS) is designed to be used together with 3D virtual reality glasses, widely available off-the -shelf products. The app features include 10x zoom, a flashlight, enhanced image contrast, autofocus, head movement control, and image stabilization. When used with an iPhone and Google cardboard glasses, this app can be used to make an inexpensive, hands-free device. New Equipment and Technology Ophthalmology Clinical Cirrus OCT 5000 (3) Zeiss with Visupac Image Processing (2) Cirrus OCT 4000 Excimer 500 Laser & Topography Hopkins O'Telescope & Portable LED Brite Lite Source VuMax Ultrasound System, Transducer, Scan Cap Kit, Probe Marco BAT Brightness Acuity Tester (9) Octopus 900 Pro System & Reliance Stool Konan Specular Microscope Cell Chek XL Touch System Coherent Opal Photo Activation PDT Laser w/ Haag Streit Laser Link & Carry case Research 58`PR Centrifuge with 5 x 500 RTR FemtoJet 4x Microinjector Leica SP8 Confocal Microscope Thermo backup core freezer Dionex HPLC Life Tech StepOne PCR Eppendorf 170S Incubator Swept source OCT COMMUNITY SERVICE ACTIVITIES Local/Regional Community Forums, Lectures and Special Events Yewlin Chee, MD, spoke at a Public Safety Committee hearing regarding firework laws. She shared her perspective having seen firsthand the devastation that fireworks eye injuries can cause to patients and their families. Dr. Chee, who is a former Chief Resident at Mass. Eye and Ear, saw two patients with open globe injuries caused by fireworks, and was responsible for caring for patients in the emergency room over the July 4th weekend during her tenure. Support Groups The Mass. Eye and Ear Ocular Plastic Surgery Service hosted a quarterly Thyroid Eye Disease support group, which is led by Suzanne Freitag, MD. This support group is run in collaboration with the Graves Disease and Thyroid Foundation along with MGH endocrinology and Dr. Greg Randolph of Mass. Eye and Ear ENT. Participating faculty include Drs. Michael Yoon, Daniel Lefebvre, Grace Lee, and Dean Cestari of Mass. Eye and Ear; and Benjamin Bleier of Mass. Eye and Ear ENT. Mass. Eye and Ear Vision Rehabilitation Support Group runs weekly for 8 weeks in the Vision Rehabilitation Clinic, and is led by a Mass. Eye and Ear social worker and a social worker who has low vision. Screenings Mass. Eye and Ear's Yan Jiang, OD, led a free vision clinic for students taking part in the Year Up Boston Program, which gives young adults from underserved communities the tools required to plan their careers and to thrive in a business environment. The MEE Longwood office team held another screening in May. Each year, a team from Mass. Eye and Ear and Children's Hospital Ophthalmology Foundation conduct vision screenings for middle-school students at Camp Harbor View. In 2015 - the event's 9th year running - staff screened 246 children in total. During the July effort, Drs. Kimberley Chan, Miin Roh, Scott Barb, and Matt Goodman, worked closely with ophthalmic technicians and Mass. Eye and Ear volunteers to administer screenings to 137 campers. In August, 109 campers were screened, of whom 21 will be seeing their primary care providers for follow-up and 12 were referred for specialty care. National Drs. Jason Comander and Leo Kim participated in the Alliance for Eye and Vision Research (AEVR) Emerging Vision Scientists Program. This program allows scientists to meet with members of Congress to discuss the importance of vision research in the continuing fight to prevent blindness. Otolaryngology Expansions The Department of Otolaryngology opened an ORL Clinic at the Mass. Eye and Ear Longwood satellite office in July 2015. Noah Siegel, M.D., is serving as Medical Director of the practice. This ambulatory clinic has an allergy room, audiology services, and vestibular rehab services, among other services. Renovations Eaton-Peabody Laboratory at Mass. Eye and Ear went under some renovations this fiscal year, which included: infrastructure improvements to the C400 suite to increase access to air, vacuum, electrical and data ports, and renovations in C454J to accommodate desks and storage solutions for four pre-doctoral and postdoctoral trainees. The adjacent room was refurbished to accommodate six small sound chambers and computer workstations. Community Service Activities Faculty and staff in the Otolaryngology Department engage in a variety of community service activities throughout the year. From free, public cancer screenings for skin cancer and head and neck cancer to public seminars on hearing loss, sinus disease and thyroid cancer, our team is dedicated to promoting public health through prevention and raising awareness in the community. -Onsite Head and Neck Cancer Screening at main campus -Expanded Public Forums, including "Sinusitis Seminar" and "Thyroid Conference" Radiology New Equipment and Technology -A 3D Accuitomo cone beam CT system was purchased in 2015 after completion of a trial period. This system is located at the main hospital Radiology department. This non-contrast CT system offers superb image quality of the temporal bone. -The siting and evaluation process for a 2nd MRI system is near complete. Findings will be presented to the executive leadership for hopeful approval. |
| FORM 990, PART VI, LINE 1A: | THE INFIRMARY'S BYLAWS STATE THE FOLLOWING: THERE SHALL BE AN EXECUTIVE COMMITTEE CONSISTING OF THOSE INDIVIDUALS WHO ARE SERVING AS MEMBERS OF THE EXECUTIVE COMMITTEE OF THE MEMBER. THE EXECUTIVE COMMITTEE SHALL HAVE THE POWER TO TRANSACT ALL EMERGENCY BUSINESS OF THE CORPORATION DURING THE PERIOD BETWEEN THE MEETINGS OF THE BOARD OF DIRECTORS. THE EXECUTIVE COMMITTEE SHALL ALSO TRANSACT SUCH BUSINESS, PERFORM SUCH DUTIES, AND EXERCISE SUCH POWERS AS MAY BE DIRECTED OR DELEGATED BY THE BOARD OF DIRECTORS FROM TIME TO TIME. THE EXECUTIVE COMMITTEE SHALL KEEP A RECORD OF ITS PROCEEDINGS. ALL ACTIONS OF THE EXECUTIVE COMMITTEE SHALL BE REPORTED TO THE BOARD OF DIRECTORS AT ITS NEXT REGULAR MEETING. FORM 990, PART VI, LINE 7A: THE GOVERNOR OF THE COMMONWEALTH HAS THE AUTHORITY TO APPOINT TWO DIRECTORS. THE BYLAWS OF THE INFIRMARY STATE THAT THE REMAINING DIRECTORS ARE THOSE INDIVIDUALS SERVING AS DIRECTORS OF ITS SOLE MEMBER, THE FOUNDATION OF THE MASSACHUSETTS EYE AND EAR INFIRMARY, INC. ("THE FOUNDATION"). |
| FORM 990, PART VI, LINE 7B: | THE FOUNDATION IS THE SOLE MEMBER OF THE INFIRMARY AND RETAINS THE AUTHORITY TO MAKE DECISIONS REGARDING THE INFIRMARY. |
| FORM 990, PART VI, LINE 11B: | THE INFIRMARY'S FORM 990 IS PREPARED BY PRICEWATERHOUSECOOPERS, LLP USING INFORMATION PREPARED BY MANAGEMENT. AFTER THE FORM 990 IS COMPLETED, IT IS REVIEWED BY THE MANAGER OF INVESTMENTS AND FOUNDATION ACCOUNTING. THE FORM 990 IS THEN PRESENTED TO THE FINANCE COMMITTEE FOR REVIEW AND APPROVAL AS AUTHORIZED BY THE BOARD OF DIRECTORS. THE BOARD OF DIRECTORS ARE ALSO GIVEN THE FORM 990 FOR REVIEW WITH TIME TO SUBMIT COMMENTS AND QUESTIONS BEFORE FINAL FILING. |
| FORM 990, PART VI, LINE 12C: | MEMBERS OF THE STAFF ARE REQUIRED TO DISCLOSE CONFLICTS OF INTEREST TO THEIR CHIEF OF SERVICE OR DEPARTMENT AND DIRECTOR OF LABORATORY/UNIT. MEMBERS OF THE BOARD OF DIRECTORS ARE REQUIRED TO DISCLOSE ANNUALLLY, IN WRITING, ANY INTERESTS THAT COULD GIVE RISE TO CONFLICTS. THE OFFICE OF THE INTERNAL LEGAL COUNSEL OBTAINS AND REVIEWS THE ANNUAL CONFLICTS OF INTEREST STATEMENTS SUBMITTED BY MEMBERS OF THE BOARD OF DIRECTORS, AND REPORTS ON THE SAME TO THE AUDIT AND COMPLIANCE COMMITTEE OF THE BOARD. WITH RESPECT TO INTERESTS DISCLOSED BY BOARD MEMBERS THAT COULD GIVE RISE TO CONFLICTS OF INTEREST, THE INTERNAL LEGAL COUNSEL REVIEWS ALL TRANSACTIONS BETWEEN SUCH INTERESTS AND AFFILIATES OF THE INFIRMARY, TO DETERMINE WHETHER THESE TRANSACTIONS WERE CONDUCTED AT ARM'S LENGTH. |
| FORM 990, PART VI, LINE 15: | THE CHAIRMAN OF THE COMPENSATION COMMITTEE OF THE BOARD OF THE INFIRMARY PRESENTS A RECOMMENDATION TO THE COMPENSATION COMMITTEE WHO HAVE FINAL APPROVAL OF THE CEO'S BASE SALARY AND BONUS AMOUNT. THE CEO RECOMMENDS EXECUTIVE SALARIES TO THE COMPENSATION COMMITTEE OF THE BOARD WHO HAS FINAL AUTHORIZATION TO APPROVE IT. TOTAL COMPENSATION FOR THE CEO, CHIEFS AND VICE PRESIDENTS, INCLUDING BONUS PAYMENTS, INCLUDING COMPARABILITY DATA, IS ANALYZED BY INDEPENDENT COMPENSATION CONSULTANTS AND IS DETERMINED TO BE REASONABLE. |
| FORM 990, PART VI, LINE 19: | SUMMARIZED FINANCIAL STATEMENTS ARE AVAILABLE ON THE INFIRMARY'S WEBSITE: WWW.MASSEYEANDEAR.ORG. AUDITED FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. THE INFIRMARY'S GOVERNING DOCUMENTS AND FORM 990 ARE AVAILABLE UPON REQUEST. THE CONFLICT OF INTEREST POLICY IS ALSO AVAILABLE UPON REQUEST. |
| FORM 990, PART XI, LINE 9: | PERIODIC PENSION PLAN COST $(13,075,540) TEMPORARY FUND BALANCE TRANSFER (360,000) TOTAL (13,435,540) |
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