Attach to Form 990 or Form 990-EZ.
Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
| (i)Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 9 above (see instructions)) | (iv) Is the organization listed in your governing document? | (v) Amount of monetary support (see instructions) | (vi) Amount of other support (see instructions) | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
| Total | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2011 | (b) 2012 | (c) 2013 | (d) 2014 | (e) 2015 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any unusual grants.) .... | 12,495,973 | 12,253,096 | 12,110,077 | 13,048,070 | 13,892,699 | 63,799,915 |
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....... | ||||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 4 | Total. Add lines 1 through 3 | 12,495,973 | 12,253,096 | 12,110,077 | 13,048,070 | 13,892,699 | 63,799,915 |
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. | 20,911,285 | |||||
| 6 | Public support. Subtract line 5 from line 4. | 42,888,630 | |||||
Calendar year
(or fiscal year beginning in) ![]() |
(a) 2011 | (b) 2012 | (c) 2013 | (d) 2014 | (e) 2015 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | 12,495,973 | 12,253,096 | 12,110,077 | 13,048,070 | 13,892,699 | 63,799,915 |
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | 52,754 | 68,767 | 780,822 | 506,380 | -485,226 | 923,497 |
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. | 108,536 | 233,817 | 510,879 | 761,128 | 937,834 | 2,552,194 |
| 11 | Total support. Add lines 7 through 10. | 67,275,606 | |||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2011 | (b) 2012 | (c) 2013 | (d) 2014 | (e) 2015 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose...... | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513... | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 6 | Total. Add lines 1 through 5. | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons... | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support. (Subtract line 7c from line 6.) | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2011 | (b) 2012 | (c) 2013 | (d) 2014 | (e) 2015 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||
| Section A - Adjusted Net Income | (A) Prior Year |
(B) Current Year (optional) |
||||
| 1 | Net short-term capital gain | 1 | ||||
| 2 | Recoveries of prior-year distributions | 2 | ||||
| 3 | Other gross income (see instructions) | 3 | ||||
| 4 | Add lines 1 through 3 | 4 | ||||
| 5 | Depreciation and depletion | 5 | ||||
| 6 | Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) | 6 | ||||
| 7 | Other expenses (see instructions) | 7 | ||||
| 8 | Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) | 8 | ||||
| Section B - Minimum Asset Amount | (A) Prior Year |
(B) Current Year (optional) |
||||
| 1 | Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): | 1 | ||||
| a | Average monthly value of securities | 1a | ||||
| b | Average monthly cash balances | 1b | ||||
| c | Fair market value of other non-exempt-use assets | 1c | ||||
| d | Total (add lines 1a, 1b, and 1c) | 1d | ||||
| e |
Discount claimed for blockage or other factors (explain in detail in Part VI): |
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| 2 | Acquisition indebtedness applicable to non-exempt use assets | 2 | ||||
| 3 | Subtract line 2 from line 1d | 3 | ||||
| 4 | Cash deemed held for exempt use. Enter 1-1/2% of line 3 (for greater amount, see instructions). | 4 | ||||
| 5 | Net value of non-exempt-use assets (subtract line 4 from line 3) | 5 | ||||
| 6 | Multiply line 5 by .035 | 6 | ||||
| 7 | Recoveries of prior-year distributions | 7 | ||||
| 8 | Minimum Asset Amount (add line 7 to line 6) | 8 | ||||
| Section C - Distributable Amount | Current Year | |||||
| 1 | Adjusted net income for prior year (from Section A, line 8, Column A) | 1 | ||||
| 2 | Enter 85% of line 1 | 2 | ||||
| 3 | Minimum asset amount for prior year (from Section B, line 8, Column A) | 3 | ||||
| 4 | Enter greater of line 2 or line 3 | 4 | ||||
| 5 | Income tax imposed in prior year | 5 | ||||
| 6 | Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) | 6 | ||||
| Section D - Distributions | Current Year | |
|---|---|---|
| 1 Amounts paid to supported organizations to accomplish exempt purposes | ||
|
2
Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity |
||
| 3 Administrative expenses paid to accomplish exempt purposes of supported organizations | ||
| 4 Amounts paid to acquire exempt-use assets | ||
| 5 Qualified set-aside amounts (prior IRS approval required) | ||
| 6 Other distributions (describe in Part VI). See instructions | ||
| 7Total annual distributions. Add lines 1 through 6. | ||
|
8
Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions |
||
| 9 Distributable amount for 2015 from Section C, line 6 | ||
| 10 Line 8 amount divided by Line 9 amount | ||
| Section E - Distribution Allocations (see instructions) |
(i) Excess Distributions |
(ii) Underdistributions Pre-2015 |
(iii) Distributable Amount for 2015 |
|
|---|---|---|---|---|
|
1
Distributable amount for 2015 from Section C, line 6 |
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|
2
Underdistributions, if any, for years prior to 2015 (reasonable cause required--see instructions) |
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| 3 Excess distributions carryover, if any, to 2015: | ||||
| a | ||||
| b | ||||
| c | ||||
| d From 2013....... | ||||
| e From 2014....... | ||||
| fTotal of lines 3a through e | ||||
| g Applied to underdistributions of prior years | ||||
| h Applied to 2015 distributable amount | ||||
|
i
Carryover from 2010 not applied (see instructions) |
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| j Remainder. Subtract lines 3g, 3h, and 3i from 3f. | ||||
| 4Distributions for 2015 from Section D, line 7: | ||||
| $ | ||||
| a Applied to underdistributions of prior years | ||||
| b Applied to 2015 distributable amount | ||||
| c Remainder. Subtract lines 4a and 4b from 4. | ||||
|
5
Remaining underdistributions for years prior to 2015, if any. Subtract lines 3g and 4a from line 2 (if amount greater than zero, see instructions) |
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|
6
Remaining underdistributions for 2015. Subtract lines 3h and 4b from line 1 (if amount greater than zero, see instructions) |
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|
7 Excess distributions carryover to 2016. Add lines 3j and 4c. |
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| 8 Breakdown of line 7: | ||||
| a | ||||
| b | ||||
| c Excess from 2013....... | ||||
| d From 2014....... | ||||
| e From 2015....... | ||||
| Facts And Circumstances Test |
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| Return Reference | Explanation |
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Attach to Form 990 or 990-EZ.
Information about Schedule O (Form 990 or 990-EZ) and its instructions is at| Return Reference | Explanation |
|---|---|
| FORM 990, PART III, LINE 3 | ON 12/31/2015, THE ORGANIZATION CEASED A MAJORITY OF ITS RESEARCH OPERATIONS. |
| FORM 990, PART VI, SECTION B, LINE 11 | A COPY OF THE FORM 990 WAS REVIEWED BY THE FINANCE COMMITTEE. AFTERWARDS THE FORM 990 WAS REVEIWED WITH THE BOARD PRIOR TO FILING. |
| FORM 990, PART VI, SECTION B, LINE 12C | THE BOARD MAINTAINS A CONFLICT OF INTEREST POLICY WHICH IS SIGNED ON AN ANNUAL BASIS. IN THE COURSE OF MEETINGS OR ACTIVITIES, EVERYONE WILL DISCLOSE ANY INTERESTS IN A TRANSACTION OR DECISION WHERE HE/SHE (INCLUDING THEIR BUSINESS OR OTHER NON-PROFIT AFFILIATIONS, FAMILY AND/OR SIGNIFICANT OTHER, EMPLOYER OR CLOSE ASSOCIATES) MAY HAVE A CONFLICT. AFTER DISCLOSURE OF ANY POSSIBLE CONFLICT OF INTEREST, THE PERSON WILL BE ASKED TO LEAVE THE ROOM FOR THE DISCUSSION AND WILL NOT BE PERMITTED TO VOTE ON THE QUESTION. |
| FORM 990, PART VI, SECTION B, LINE 15 | HUMAN RESOURCES PREPARES MARKET ANALYSIS OF SALARY SURVEY AND OTHER DATA TO PROVIDE RECOMMENDATIONS TO THE INDEPENDENT COMPENSATION COMMITTEE, WHO REVIEWS THESE DATA ALONG WITH PERFORMANCE EVALUATIONS TO APPROVE ANY SALARY ADJUSTMENTS. |
| FORM 990, PART VI, SECTION C, LINE 18 | THE ORGANIZATION'S FORM 990 IS MADE AVAILABLE TO THE PUBLIC UPON REQUEST AND ON WWW.GUIDESTAR.ORG. |
| FORM 990, PART VI, SECTION C, LINE 19 | THE GOVERNING DOCUMENTS, CONFLICT OF INTEREST STATEMENT, AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. |
| FORM 990, PART IX, LINE 11G | CONTRACT SERVICES: PROGRAM SERVICE EXPENSES 578,209. MANAGEMENT AND GENERAL EXPENSES 9,152. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 587,361. CONSULTANTS: PROGRAM SERVICE EXPENSES 853,515. MANAGEMENT AND GENERAL EXPENSES 891,727. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 1,745,242. OTHER FEES: PROGRAM SERVICE EXPENSES 57. MANAGEMENT AND GENERAL EXPENSES 3,692. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 3,749. |
| FORM 990, PART XI, LINE 9: | HREF ACTIVITY -7,462. |
| FORM 990, PART XII, LINE 2C: | THIS PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR. |
| FORM 990, PART III, LINE 4A: | JANUARY 2015: PUBLICATION - JOURNAL OF IMMUNOLOGY - MODULATING DNA METHYLATION IN ACTIVATED CD8+ T CELLS INHIBITS REGULATORY T CELL-INDUCED BINDING OF FOXP3 TO THE CD8+ T CELL IL-2 PROMOTER FEBRUARY 2015: THE HAMNER ANNOUNCES FORMATION OF THE COMPREHENSIVE CENTER FOR LIVER AND METABOLIC DISEASE RESEARCH ASTELLAS PHARMA JOINS THE DILI-SIM INITIATIVE MARCH/APRIL 2015: THE HAMNER RELEASES DILISYM V4A AND MITOSYM V2B SCIENTISTS AT THE HAMNER INSTITUTES RECEIVE TEN AWARDS FROM SOCIETY OF TOXICOLOGY PUBLICATION FRONTIERS IN PHARMACOLOGY IDENTIFYING GENES THAT MEDIATE ANTHRACYLINE TOXICITY IN IMMUNE CELLS PUBLICATION ENVIRONMENTAL AND MOLECULAR MUTAGENSIS - EVALUATION OF GENE EXPRESSION CHANGES IN HUMAN PRIMARY LUNG EPITHELIAL CELLS FOLLOWING 24-HR EXPOSURES TO INORGANIC ARSENIC AND ITS METHYLATED METABOLITES AND TO ARSENIC TRIOXIDE PUBLICATION ARCHIVOS DE MEDICINA VETERNARIA - BUILDING SHARED EXPERIENCE TO ADVANCE PRACTICAL APPLICATION OF PATHWAY-BASED TOXICOLOGY: LIVER TOXICITY MODE-OF-ACTION MAY 2015: SEMINAR - "FRET-BASED BIOSENSORS FOR PROBING RHO FAMILY GTPASE SIGNALING NETWORKS" SEMINAR - "GENETIC TOXICOLOGY: OVERVIEW AND LESSONS LEARNED" SEMINAR - "MANIPULATION OF THE HOST ENVIRONMENT BY KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS" PHOUNDRY PHARMACEUTICALS JOINED THE HAMNER'S BIOSCIENCES ACCELERATOR PUBLICATION TOXICOLOGY - A CASE STUDY ON QUANTITATIVE IN VITRO TO IN VIVO EXTRAPOLATION FOR ENVIRONMENTAL ESTERS: METHYL-, PROPYL- AND BUTYLPARABEN JUNE 2015: SEMINAR - "ASSESSING REAL-TIME CELLULAR RESPONSES TO INTERPRET EXPOSURE-BIOACTIVITY PROFILES OF FRUIT AND VEGETABLE JUICES" SEMINAR - "COMPUTER MODELING OF BIOLOGICAL SYSTEMS: MECHANISTIC MODELS OF BIOFILAMENTS AND HUMAN PHYSIOLOGY" SEMINAR - "HUMAN HEALTH RISK ASSESSMENT BY COUPLING A CONTINUOUS MICROBIAL FATE AND TRANSPORT MODEL WITH A STOCHASTIC MODEL" SEMINAR - "A NON-TARGETED METHOD TO SCREEN FOR EMERGING CONTAMINANTS IN HOUSE DUST" DR. MICHELLE MILLER, HAD A PAPER SELECTED ONE OF THE TOP 5 PUBLICATIONS IN 2014 FOR VETERINARY IMMUNOLOGY, AS CHOSEN BY THE AMERICAN COLLEGE OF VETERINARY INTERNAL MEDICINE. PUBLICATION TOXICOLOGY USE OF IN VITRO DATA IN DEVELOPING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL: CARBARYL AS A CASE STUDY PUBLICATION ENVIRONMENTAL AND MOLECULAR MUTAGENESIS - EVALUATION OF GENE EXPRESSION CHANGES IN HUMAN PRIMARY LUNG EPITHELIAL CELLS FOLLOWING 24-HR EXPOSURES TO INORGANIC ARSENIC AND ITS METHYLATED METABOLITES AND TO ARSENIC TRIOXIDE PUBLICATION JOURNAL OF APPLIED TOXICOLOGY - ADVERSE OUTCOME PATHWAYS CAN DRIVE NON-ANIMAL APPROACHES FOR SAFETY ASSESSMENT JULY 2015: SEMINAR - "APPLICATION OF MINIMAL PBPK MODELS TO GUIDE THE DEVELOPMENT OF THERAPEUTIC ANTIBODIES" THE HAMNER LAUNCHED DILISYM SERVICES, INC. PUBLICATION CHEMICO-BIOLOGICAL INTERACTIONS A PRELIMINARY REGIONAL PBPK MODEL OF LUNG METABOLISM FOR IMPROVING SPECIES DEPENDENT DESCRIPTIONS OF 1,3-BUTADIENE AND ITS METABOLITES PUBLICATION PHARMACEUTICAL RESEARCH MITOSYM : A MECHANISTIC, MATHEMATICAL MODEL OF HEPATOCELLULAR RESPIRATION AND BIOENERGETICS PUBLICATION ENVIRONMENTAL HEALTH PERSPECTIVES MOLECULAR SIGNALING NETWORK MOTIFS PROVIDE A MECHANISTIC BASIS FOR CELLULAR THRESHOLD RESPONSES PUBLICATION ISSUES IN TOXICOLOGY - MODELING MANGANESE KINETICS FOR HUMAN HEALTH RISK ASSESSMENT AUGUST/SEPTEMBER 2015: SEMINAR - "INVESTIGATIONS INTO HEPATIC AND RENAL DRUG SAFETY - BIOMARKERS AND THERAPEUTIC INTERVENTIONS" PUBLICATION VIROLOGY - HP-PRRSV IS ATTENUATED BY DE-OPTIMIZATION OF CODON PAIR BIAS IN ITS RNA-DEPENDENT RNA POLYMERASE NSP9 GENE PUBLICATION REGULATORY TOXICOLOGY AND PHARMACOLOGY - USING GENE EXPRESSION PROFILING TO EVALUATE CELLULAR RESPONSES IN MOUSE LUNGS EXPOSED TO V2O5 AND A GROUP OF OTHER MOUSE LUNG TUMORIGENS AND NON-TUMORIGENS PUBLICATION JOURNAL OF APPLIED TOXICOLOGY - ARYL HYDROCARBON RECEPTOR KNOCKOUT RATS ARE INSENSITIVE TO THE PATHOLOGICAL EFFECTS OF REPEATED ORAL EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN OCTOBER/NOVEMBER/DECEMBER 2015: POSTDOC SEMINAR - "DEVELOPING A TESTING STRATEGY FOR OXIDATIVE STRESS RESPONSE" PUBLICATION TOXICOLOGY SCIENCES - THE CONTRIBUTION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA TO THE RELATIONSHIP BETWEEN TOXICOKINETICS AND TOXICODYNAMICS OF TRICHLOROETHYLENE PUBLICATION TOXICOLOGY SCIENCES - ADAPTIVE POSTTRANSLATIONAL CONTROL IN CELLULAR STRESS RESPONSE PATHWAYS AND ITS RELATIONSHIP TO TOXICITY TESTING AND SAFETY ASSESSMENT |
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