Form990
Department of the TreasuryInternal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private
foundations)
MediumBullet Do not enter social security numbers on this form as it may be made public.
MediumBullet Information about Form 990 and its instructions is at www.IRS.gov/form990.
OMB No. 1545-0047
2015
Open to Public Inspection
A For the 2015 calendar year, or tax year beginning 09-01-2015 , and ending 08-31-2016
BCheck if applicable:
CName of organization
Howard Hughes Medical Institute
 
 
Doing business as
 
 
Number and street (or P.O. box if mail is not delivered to street address)
4000 JONES BRIDGE ROAD
 
Room/suite
City or town, state or province, country, and ZIP or foreign postal code
CHEVY CHASE, MD20815
D Employer identification number

59-0735717
E Telephone number

G Gross receipts $ 60,901,814,102
F Name and address of principal officer:
ERIN K O'SHEA PHD
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.HHMI.ORG
H(a)
Is this a group return for
subordinates?
H(b)
Are all subordinates
included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:  
L Year of formation: 1953
M State of legal domicile: DE
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: THE HOWARD HUGHES MEDICAL INSTITUTE IS A PHILANTHROPY THAT SERVES SOCIETY THROUGH THE DIRECT CONDUCT OF BIOMEDICAL RESEARCH AND SUPPORT FOR PROGRAMS IN SCIENCE EDUCATION.
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 10
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 10
5 Total number of individuals employed in calendar year 2015 (Part V, line 2a) ...... 5 3,383
6 Total number of volunteers (estimate if necessary) ............. 6 0
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a -1,833,057
b Net unrelated business taxable income from Form 990-T, line 34 ......... 7b 0
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 66,401 19,321,241
9 Program service revenue (Part VIII, line 2g) ......... 2,033,219 2,223,162
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 1,963,222,595 921,724,327
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 17,244,324 257,052,143
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12) 1,982,566,539 1,200,320,873
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 46,910,392 138,793,048
14 Benefits paid to or for members (Part IX, column (A), line 4).....   0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 422,462,257 438,554,171
16a Professional fundraising fees (Part IX, column (A), line 11e) .....   0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet0    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 544,226,576 556,129,969
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 1,013,599,225 1,133,477,188
19 Revenue less expenses. Subtract line 18 from line 12....... 968,967,314 66,843,685
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 21,693,736,438 21,082,502,290
21 Total liabilities (Part X, line 26)............. 3,522,501,322 3,306,942,737
22 Net assets or fund balances. Subtract line 21 from line 20..... 18,171,235,116 17,775,559,553
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
Preparer's signature
Date
PTIN
Firm's name MediumBullet
Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ..........
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y Form 990 (2015)
Form 990 (2015)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III ..............
1
Briefly describe the organization’s mission: THE HOWARD HUGHES MEDICAL INSTITUTE ("INSTITUTE" OR "HHMI") IS THE NATION'S LARGEST PRIVATE BIOMEDICAL RESEARCH INSTITUTION, WITH JUST UNDER $18 BILLION IN NET ASSETS AT THE END OF ITS 2016 FISCAL YEAR. THE MISSION OF THE INSTITUTE HAS REMAINED CONSTANT SINCE ITS FOUNDING IN 1953. AS ITS CHARTER STATES "THE PRIMARY PURPOSE AND OBJECTIVE OF THE HOWARD HUGHES MEDICAL INSTITUTE SHALL BE THE PROMOTION OF HUMAN KNOWLEDGE WITHIN THE FIELD OF BASIC SCIENCES (PRINCIPALLY THE FIELD OF MEDICAL RESEARCH AND EDUCATION) AND THE EFFECTIVE APPLICATION THEREOF FOR THE BENEFIT OF MANKIND."
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? .....................
If "Yes," describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ...........................
If "Yes," describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 711,129,790 including grants of $ 0 ) (Revenue $ 2,169,244 )
MEDICAL RESEARCH ORGANIZATION ACTIVITIES (A) THE HHMI INVESTIGATOR PROGRAM (B) JANELIA RESEARCH CAMPUS (C) HIGHLIGHTS FROM HHMI RESEARCH LABORATORIES (FISCAL YEAR 2016) (D) HONORS AND AWARDS RECEIVED BY HHMI SCIENTISTS (A) THE HHMI INVESTIGATOR PROGRAM THE HOWARD HUGHES MEDICAL INSTITUTE'S APPROACH TO BIOMEDICAL RESEARCH CAN BE SUMMARIZED IN THREE WORDS: PEOPLE, NOT PROJECTS. BY EMPLOYING SCIENTISTS AS HHMI INVESTIGATORS - RATHER THAN AWARDING RESEARCH GRANTS - THE INSTITUTE PROVIDES LONG-TERM, FLEXIBLE FUNDING THAT ENABLES ITS RESEARCHERS TO PURSUE THEIR SCIENTIFIC INTERESTS WHEREVER THEY LEAD. HHMI BELIEVES THAT SCIENTISTS OF EXCEPTIONAL TALENT AND IMAGINATION WILL MAKE FUNDAMENTAL DISCOVERIES OF LASTING SCIENTIFIC VALUE AND BENEFIT TO HUMANITY IF THEY ARE GIVEN THE RESOURCES, TIME, AND FREEDOM TO PURSUE CHALLENGING QUESTIONS. THE INSTITUTE NURTURES THE CREATIVITY AND INTELLECTUAL DARING OF SCIENTISTS WHO ARE WILLING TO SET ASIDE CONVENTIONAL WISDOM OR THE "EASY" QUESTION FOR A FUNDAMENTAL PROBLEM THAT MAY TAKE MANY YEARS TO SOLVE. AMONG THE CHARACTERISTICS THAT DISTINGUISH THIS GROUP OF SCIENTISTS ARE QUALITIES SUCH AS CREATIVITY, A PENCHANT FOR RISK-TAKING, AND A COMMITMENT TO DISCOVERY, PRODUCTIVITY, AND PERSEVERANCE. THIS UNIQUE RESEARCH MODEL IS AN IMAGINATIVE AND POWERFUL ALTERNATIVE TO FUNDING BIOMEDICAL RESEARCH THROUGH GRANTS. THE HHMI INVESTIGATOR PROGRAM EMPLOYS MORE THAN 300 HHMI INVESTIGATORS, AMONG THEM 17 NOBEL LAUREATES AND 192 MEMBERS OF THE NATIONAL ACADEMY OF SCIENCES. HHMI INVESTIGATORS DIRECT INSTITUTE RESEARCH LABORATORIES ON THE CAMPUSES OF 65 UNIVERSITIES AND OTHER RESEARCH ORGANIZATIONS THROUGHOUT THE UNITED STATES. SINCE THE EARLY 1990S, INVESTIGATORS HAVE BEEN SELECTED THROUGH RIGOROUS NATIONAL COMPETITIONS. THE INSTITUTE SOLICITS APPLICATIONS DIRECTLY FROM SCIENTISTS AT MEDICAL SCHOOLS AND OTHER RESEARCH INSTITUTIONS IN THE UNITED STATES, WITH THE AIM OF IDENTIFYING THOSE WHO HAVE THE POTENTIAL TO MAKE SIGNIFICANT CONTRIBUTIONS TO SCIENCE. HHMI EMPLOYS AN OPEN APPLICATION PROCESS TO ENSURE THAT IT IS SELECTING ITS RESEARCHERS FROM A BROAD AND DEEP POOL OF SCIENTIFIC TALENT. In October 2015, the Royal Swedish Academy of Sciences selected Paul Modrich, an HHMI investigator at Duke University, together with Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in the UK and Aziz Sancar of University of North Carolina, Chapel Hill, as recipients of the 2015 Nobel Prize in Chemistry for mechanistic studies of DNA repair. The trio was honored for mapping, at a molecular level, how cells repair damaged DNA and safeguard the genetic information. According to the Nobel Foundation, their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments. In June 2016, the HHMI Trustees elected David E. Clapham, MD, PhD, an HHMI investigator at Boston Children's Hospital, as Vice President and Chief Scientific Officer. Clapham was the Aldo R. Castaneda Professor of Cardiovascular Research at Children's Hospital Boston and Professor of Neurobiology and Pediatrics at Harvard Medical School. A member of both the National Academy of Sciences and the American Academy of Arts and Sciences, he is a leader in the field of ion channel research. His research focuses on the role of calcium as an intracellular messenger and on the signals that control ion channels that carry calcium between cells. The identification and characterization of ion channels may make it possible to develop drugs that alleviate many disorders. Clapham succeeds Erin O'Shea, PhD, who was named president of HHMI . In HHMI launched the Transformative Technology Program that allows HHMI Investigators to acquire cutting-edge research equipment for their institution that simultaneously benefits their HHMI and non-HHMI colleagues. Through cost sharing with host institutions, the Transformative Technology Program provides a path by which HHMI scientists and colleagues can obtain research equipment that's typically difficult to fund. In general, this program will purchase and own the major equipment items, while the host institution's cost-sharing funds will support the ongoing setup and operation of the core facilities that house the instruments. In this initial competition, HHMI invested a total of $18.8 million for six projects that will benefit researchers around the country. This year, HHMI, the Simons Foundation, and the Bill & Melinda Gates Foundation selected 84 Faculty Scholars, early-career scientists who have great potential to make unique contributions to their field. The scientists represent 43 institutions across the United States. Through the new Faculty Scholars Program, the philanthropies will spend about $83 million over five years to support the first cohort of scientists selected to receive grants. The range of five-year grant award totals is $600,000-$1.8 million, including indirect costs. Faculty Scholars are required to devote at least 50 percent of their total effort to the direct conduct of research. Highlights of research conducted, and awards received, by HHMI scientists during its year ended August 31, 2016 are included below. (B) Janelia Research Campus The Janelia Research Campus offers a collaborative research environment for scientists across an array of disciplines who have focused on two broad scientific areas of scientific inquiry: the identification of general principles governing how neuronal circuits process information and development of imaging technologies and computational methods that support image analysis. In the current fiscal year, there were 47 group leaders at Janelia, in addition to graduate students, other scientific trainees, and visiting scientists. Janelia also operates a vibrant scientific conference program, bringing many scientists to its campus each year for educational meetings . In 2016, Janelia expanded its research program by launching a Neuronal Cell Biology Program that will support scientists investigating the structural and functional details of discrete neurons and exploring the inner landscape of these cells in dynamic neural environments, and leverage existing research and tools created at Janelia, such as the lattice light sheet microscope. The program will be led by Jennifer Lippincott-Schwartz, who moved to Janelia after 23 years as chief of the section on organelle biology in the Cell Biology and Metabolism Program, in the Division of Intramural Research at the National Institutes of Health (NIH).
4b (Code:   ) (Expenses $ 147,854,974 including grants of $ 117,992,048 ) (Revenue $ 53,918 )
SCIENCE EDUCATION PROGRAMS (A) GRADUATE SCIENCE EDUCATION AND MEDICAL RESEARCH TRAINING (B) PRECOLLEGE AND UNDERGRADUATE SCIENCE EDUCATION PROGRAM (C) EDUCATIONAL MEDIA (D) TANGLED BANK STUDIOS (E) ELIFE - OPEN ACCESS JOURNAL HHMI'S DEPARTMENT OF SCIENCE EDUCATION EMPHASIZES INITIATIVES WITH THE POWER TO TRANSFORM GRADUATE, UNDERGRADUATE, AND PRECOLLEGE EDUCATION IN THE LIFE SCIENCES. HHMI IS THE LARGEST PRIVATE FUNDER OF SCIENCE EDUCATION IN THE UNITED STATES. DURING THE FISCAL YEAR, THE INSTITUTE DISTRIBUTED $57 MILLION IN GRANTS TO SUPPORT SCIENCE EDUCATION. The Institute's science education programs support ties between scientific research and teaching with the goal of increasing and enhancing student research opportunities; improving science courses, curricula, and instruction; and providing enhanced graduate and medical training opportunities. Most HHMI grants are awarded through competitions with specific objectives and eligibility criteria and awards are generally made following a stringent process of peer review. HHMI's educational activities are funded through three major programs; the goals of each program and the major activities for the year are summarized below. (A) Graduate Science Education and Medical Research Training These programs focus on the development of innovative graduate education through grants to institutions and fellowships to students. They support research fellowships for medical students, doctoral fellowships for students who are committed to increasing diversity among scientists, doctoral fellowships for international students pursuing the PhD at U.S. institutions. This fiscal year, HHMI selected 66 medical and veterinary students to participate in the Medical Research Fellows Program. The fellowships enable students to take a year off from professional school to conduct laboratory research. The hope is that these students will one day choose to work at the crossroads of basic research and clinical medicine. Six fellows in this year's class of 66 initial awardees are supported by HHMI's funding partners: Burroughs Wellcome Fund (BWF), Citizens United for Research in Epilepsy (CURE), the Duchenne Research Fund (DRF), and the Society of Interventional Radiology Foundation (SIRF). The program has funded more than 1,700 students since its start in 1989. This year, 13 fellows from the 2015 class are supported by HHMI for an additional year, making it the largest class of second-year fellows in the program's history. The program usually averages six second-year fellows per year. The International Predoctoral Fellowship program identifies accomplished and promising graduate students whose home countries are outside of the United States and who are ineligible for U.S. federal training grant support. Each fellowship is for three years, and pays a stipend, institutional allowance, and research allowance totaling $43,000 per year. In fiscal year 2016, HHMI selected 20 graduate students as International Predoctoral Fellows. HHMI's Gilliam Fellowships for Advanced Study Program awarded 34 fellowships to outstanding students who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists. Each fellow will receive an annual award totaling $46,000, which includes a stipend, a training allowance, and an allowance for each fellow's institution, for up to three years. The applicant pool for the Gilliam fellowships consists of graduate students nominated by the principal investigators of non-MSTP T32 training grants awarded through the National Institute of General Medical Sciences (NIGMS), and alumni of HHMI's Exceptional Research Opportunities Program (EXROP), an initiative that provides undergraduate minority students with the opportunity to conduct research under the mentorship of HHMI scientists. A total of 142 students applied for the fellowships this year, including 18 EXROP alumni. (B) Precollege and Undergraduate Science Education Program These programs recruit and develop the future leaders of science and enhance science literacy among all students. Precollege grants support teacher training and inquiry-based student learning. Grants to colleges and universities support undergraduate student research, faculty and curriculum development, and science education outreach activities. In the 2016 fiscal year: HHMI has invited 91 schools to submit full proposals to apply for grants through HHMI's $60 million Inclusive Excellence initiative that is encouraging colleges and universities to broaden access to science excellence for all students. The proposals will be considered for first-round awards that will begin in September 2017. HHMI plans to award approximately 60 grants in two rounds of open competitions, each of which will follow the same format. In this round of the competition, HHMI will award up to 30 grants to institutions that are committed to inclusive science education and are well positioned to work over the next five years to improve their ability to become more inclusive of all students. HHMI's long-term aim is for successful strategies pioneered by the grantee institutions to serve as models to be adapted and adopted by other institutions. The 91 schools were selected from 511 that submitted pre-proposals in response to HHMI's launch of the initiative in May 2015. HHMI continued its partnership with the University of Maryland, Baltimore County (UMBC), the Pennsylvania State University, and the University of North Carolina at Chapel Hill (UNC), to launch the collaborative Meyerhoff Adaptation Project. The project aims to learn whether elements of UMBC's highly regarded Meyerhoff Scholars Program can be adapted at Penn State and UNC. The participating schools hope to share what they learn so other institutions might follow. During the five-year Meyerhoff Adaptation Project, Penn State and UNC, working closely with UMBC and HHMI, will expand and study the Meyerhoff model, while applying it to newly created programs on their campuses. The HHMI Professors Program empowers research scientists who can convey the excitement of science to undergraduates. The professors model fundamental reform in the way undergraduate science is taught at research universities through innovative teaching that demonstrates the rigor and value of scientific research. HHMI professors are committed to expanding and enhancing research opportunities for undergraduates and are encouraged to share ideas and collaborate with their peers to improve science education. Fifty-five scientists have been named HHMI professors since the program began in 2002. In addition to their commitment to student learning, these highly visible scientists have developed new educational resources and implemented novel mentoring programs to support students. In April 2016, HHMI announced a competition to select up to 15 new HHMI professors who will each receive a five-year, nonrenewable grant totaling $1 million; these awards will be made in the fall of 2017. The HHMI's Exceptional Research Opportunities Program (EXROP) is designed to encourage talented students to pursue careers in science by placing selected undergraduates in summer research experiences in the labs of HHMI investigators, professors, and at the Janelia Research Campus. In 2016, a total of 102 college students (69 first-year students and 33 second-year, "EXROP Capstone" students) were selected to participate in EXROP. The 2016 cohort marked the 14th year of the program.
4c (Code:   ) (Expenses $ 20,914,932 including grants of $ 20,801,000 ) (Revenue $ 0 )
SUPPORT FOR INTERNATIONAL SCIENCE (A) NEW INTERNATIONAL RESEARCH SCHOLARS PROGRAM (B) SENIOR INTERNATIONAL RESEARCH SCHOLARS PROGRAM (C) INTERNATIONAL EARLY CAREER SCIENTIST PROGRAM (D) AFRICA HEALTH RESEARCH INSTITUTE LAUNCHES IN SOUTH AFRICA (A) New International Research Scholars Program HHMI, together with the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation, announced an international program to provide research support for up to 40 outstanding early career scientists. The program's aim is to help develop scientific talent worldwide in a wide variety of biomedical research fields. Awardees will be notified in April 2017. HHMI and its partners have committed a total of $30 million for the International Research Scholars Program and will award each scientist who is selected a total of $650,000 over five years. The competition is open to scientists who have trained in the U.S. or United Kingdom for at least one year and who have run their own labs for less than seven years. (B) Senior International Research Scholars Program HHMI continues to support 13 of the world's leading basic science researchers as Senior International Research Scholar (SIRS). The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences. The SIRS awardees, selected from a group of previous HHMI international research scholars, are respected leaders in their fields. Each HHMI senior international research scholar receives a grant of $100,000 per year over five years, and presents their research at scientific meetings held at HHMI. The gatherings are intended to facilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaboration with other HHMI scientists. The senior international research scholars' participation helps strengthen the growing network of international biomedical researchers. (C) International Early Career Scientist Program HHMI continues to support 24 international early career scientists who were selected for awards in 2012. Each selected scientist will receive $650,000 over a period of five years with the goal of helping these talented individuals establish independent research programs. In this pilot program, HHMI identified scientists who are, or have the potential to become, scientific leaders. The 24 HHMI international early career scientists conduct research at 20 institutions in 12 countries. Each scientist who was selected had directed his or her own laboratory for less than seven years when they applied to HHMI. The countries represented by the HHMI international early career scientists are Argentina, Brazil, Chile, China, Hungary, India, Italy, Poland, Portugal, South Africa, Spain, and South Korea. (D) Africa Health Research Institute Launches in South Africa In 2009, HHMI helped launch the KwaZulu-Natal Research Institute for TB-HIV (K-RITH) in collaboration with the University of KwaZulu-Natal (UKZN), and has provided significant funding to support its research efforts. In 2016, in a move to improve the health of people locally and globally, K-RITH joined forces with the Africa Centre for Population Health to form a groundbreaking new interdisciplinary institute to fight tuberculosis (TB), HIV and related diseases. The new organization, the Africa Health Research Institute, is located at the heart of South Africa's TB and HIV co-epidemic in KwaZulu-Natal Province. The effort brings together the Africa Centre's detailed population data from over 100,000 participants, with K-RITH's expertise in basic science and its world-class laboratory facilities. The new venture is made possible through grants from HHMI and Wellcome Trust, with the University College London and UKZN as significant academic partners. The Africa Health Research Institute is committed to working towards the elimination of HIV and TB. To achieve this, the institute will bring together leading researchers from different fields, use cutting-edge science to improve people's health, and will help to train the next generation of African scientists.
4d Other program services (Describe in Schedule O.)
(Expenses $   including grants of $   ) (Revenue $   )
4e Total program service expensesMediumBullet879,899,696
Form 990 (2015)
Form 990 (2015)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule AClick to see attachment.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? Click to see attachment...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part I.............
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part IIClick to see attachment..............
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If "Yes," complete Schedule C, Part III.................
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part I..................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part II...
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes," complete Schedule D, Part III .............
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IV..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi-endowments? If "Yes," complete Schedule D, Part V......
10
 
No
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10?
If "Yes," complete Schedule D, Part VI.Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIClick to see attachment.......
11b
Yes
 
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIII.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IX............
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part XClick to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part X
11f
 
No
12a
Did the organization obtain separate, independent audited financial statements for the tax year?
If "Yes," complete Schedule D, Parts XI and XII .................
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States? .....
14a
Yes
 
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV.........Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV.....Click to see attachment
15
Yes
 
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV...Click to see attachment
16
Yes
 
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I (see instructions) ....
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....
20a
 
No
b
If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
Form 990 (2015)
Form 990 (2015)
Page 4
Part IV
Checklist of Required Schedules (continued)
21
Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II.....Click to see attachment
21
Yes
 
22
Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........Click to see attachment
22
Yes
 
23
Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a...............Click to see list of attachments
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............
24c
 
No
d
Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I............
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I ...................
25b
 
No
26
Did the organization report any amount on Part X, line 5, 6, or 22 for receivables from or payables to any current or former officers, directors, trustees, key employees, highest compensated employees, or disqualified persons? If "Yes," complete Schedule L, Part II ................
26
 
No
27
Did the organization provide a grant or other assistance to an officer, director, trustee, key employee, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part III.........
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, or key employee? If "Yes," complete Schedule L,
Part IV ........................
28a
 
No
b
A family member of a current or former officer, director, trustee, or key employee? If "Yes," complete Schedule L, Part IV.....................
28b
 
No
c
An entity of which a current or former officer, director, trustee, or key employee (or a family member thereof) was an officer, director, trustee, or direct or indirect owner? If "Yes," complete Schedule L, Part IV...
28c
 
No
29
Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M..
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M .............
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I.
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II ...........
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I ........Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1.........................Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ...Click to see attachment
35b
Yes
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2.............
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VI
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Form 990 (2015)
Form 990 (2015)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........
Yes
No
1a
Enter the number reported in Box 3 of Form 1096 Enter -0- if not applicable ..
1a
801
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
3,383
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..
4a
Yes
 
b
If "Yes," enter the name of the foreign country: MediumBulletAS , AU , BD , CA , CJ , VI , BR , BE , CI , CH , CO , EZ , DA , FI , FR , GM , GR , GK , HK , IN , ID , EI , IT , JA , JE , KS , LU , MP , MY , MX , NZ , NL , NO , PL , PO , RS , SN , SF , SP , SW , SZ , TW , TH , TU , AE , UK , RP , AR , EG , EN , HU , IS , JO , KE , MO , NI , PE , RO , CE , UP , UY , VE , ZI
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...
6a
 
No
b
If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................
7a
 
No
b
If "Yes," did the organization notify the donor of the value of the goods or services provided? .....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................
7c
 
No
d
If "Yes," indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds.
Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? .........................
8
 
 
9a
Did the sponsoring organization make any taxable distributions under section 4966?...
9a
 
 
b
Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If "Yes," enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state?
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..
14b
 
 
Form 990 (2015)
Form 990 (2015)
Page 6
Part VI
Governance, Management, and Disclosure For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI ..............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year
1a
10
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent
1b
10
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
 
No
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? ...........................
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
 
No
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .......................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If "No," go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe in Schedule O how this was done...................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the States with which a copy of this Form 990 is required to be filedMediumBullet
AK , AZ , CA , IL , MD , MA , NY , OK , OR , IN
18
Section 6104 requires an organization to make its Form 1023 (or 1024 if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBulletNITIN V KOTAK4000 JONES BRIDGE ROAD   CHEVY CHASE,MD20815 (301) 215-8500
Form 990 (2015)
Form 990 (2015)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII ..............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

List persons in the following order: individual trustees or directors; institutional trustees; officers; key employees; highest
compensated employees; and former such persons.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(1) JAMES A BAKER III ESQ
 
TRUSTEE
 2.0
.................
  		X           40,000 0 0
(2) CHARLENE BARSHEFSKY ESQ
 
TRUSTEE
 2.0
.................
  		X           40,000 0 0
(3) JOSEPH L GOLDSTEIN MD
 
TRUSTEE, CHAIRMAN RESEARCH COMM
 4.0
.................
  		X           56,000 0 0
(4) GARNETT L KEITH
 
TRUSTEE, CHAIRMAN FINANCE COMM until 2/16
 4.0
.................
  		X           50,000 0 0
(5) FRED R LUMMIS
 
TRUSTEE, CHAIRMAN FINANCE COMM starting 2/16
 4.0
.................
  		X           40,000 0 0
(6) PAUL M NURSE PHD
 
TRUSTEE
 2.0
.................
  		X           46,000 0 0
(7) ALISON F RICHARD PHD
 
TRUSTEE, CHAIRMAN EDUCATION COMM
 2.0
.................
  		X           50,000 0 0
(8) CLAYTON S ROSE PHD
 
TRUSTEE, CHAIRMAN AUDIT & COMP
 6.0
.................
  		X           50,000 0 0
(9) KURT L SCHMOKE ESQ
 
TRUSTEE, CHAIRMAN
 6.0
.................
  		X           60,000 0 0
(10) DEBORAH L SPAR PHD
 
TRUSTEE
 2.0
.................
  		X           0 0 0
(11) ANNE M TATLOCK
 
TRUSTEE
 2.0
.................
  		X           40,000 0 0
(12) LANDIS ZIMMERMAN
 
VP & CHIEF INVESTMENT OFFICER
 40.0
.................
  		    X       3,611,224 0 56,631
(13) LAUREN T SPILIOTES ESQ
 
DEP GENCOUNSEL/ASST SEC
 40.0
.................
  		    X       382,251 0 49,552
(14) SUSAN S PLOTNICK
 
ASSISTANT TREASURER & DIRECTOR-FINANCE
 40.0
.................
  		    X       235,740 0 55,201
(15) MONIQUE L MARCUS
 
CONTROLLER
 40.0
.................
  		    X       183,211 0 45,647
(16) ROBERT TJIAN PHD
 
PRESIDENT
 40.0
.................
  		    X       1,364,377 0 72,244
(17) CHERYL A MOORE
 
EXECUTIVE VP & COO
 40.0
.................
  		    X       891,077 0 47,771
Form 990 (2015)
Form 990 (2015)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and Title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W- 2/1099-MISC) 		(E)
Reportable compensation from related organizations (W- 2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(18) SEAN B CARROLL PHD
 
VP FOR SCIENCE EDUCATION
 40.0
.......................   		    X       690,554 0 53,014
(19) HEIDI E HENNING ESQ
 
VP,GENERAL COUNSEL/SEC
 40.0
.......................   		    X       565,186 0 54,742
(20) NITIN V KOTAK
 
VP, CFO & TREASURER
 40.0
.......................   		    X       406,965 0 57,153
(21) ERIN K O'SHEA PHD
 
VP & CHIEF SCI OFF
 40.0
.......................   		    X       753,361 0 45,598
(22) JOHN PALMISANO
 
VP FOR INFORMATION TECHNOLOGY effective 11/15
 40.0
.......................   		    X       31,622 0 3,283
(23) GERALD M RUBIN PHD
 
VP&EXEC DIR,JANELIA RES CAMPUS
 40.0
.......................   		    X       744,485 0 123,162
(24) KATHY WYSZYNSKI
 
VP, HUMAN RESOURCES
 40.0
.......................   		    X       279,928 0 40,532
(25) RICHARD A PENDER
 
MAN DIR - US EQUITIES
 40.0
.......................   		      X     976,092 0 53,710
(26) ROBERT J KOLYER JR
 
MAN DIR - DIVERSIFIED ASSETS
 40.0
.......................   		      X     1,459,392 0 54,773
(27) MARK A BARNARD
 
MAN DIR - PRIVATE EQUITIES
 40.0
.......................   		      X     1,280,482 0 58,403
(28) STEPHEN M KITSOULIS
 
MAN DIR - FIXED INCOME
 40.0
.......................   		      X     903,019 0 47,198
(29) GREGORY DENINNO
 
MAN DIR - PRIVATE EQUITIES
 40.0
.......................   		      X     587,265 0 56,996
(30) ANIL MADHOK
 
MAN DIR - INVESTMENTS & COO
 40.0
.......................   		        X   1,118,843 0 41,031
(31) DONALD KOCH
 
MAN DIR - PORTFOLIO STRATEGY
 40.0
.......................   		        X   978,620 0 58,524
(32) THOMAS R CECH PHD
 
INVESTIGATOR
 40.0
.......................   		        X   629,730 0 52,258
(33) RYAN L MATNEY
 
DIRECTOR-DIVERSIFIED ASSETS
 40.0
.......................   		        X   603,568 0 56,286
(34) ERIC R KANDEL MD
 
SENIOR INVESTIGATOR
 40.0
.......................   		        X   596,905 0 58,434
(35) MOHAMOUD JIBRELL
 
VP FOR INFORMATION TECHNOLOGY
 40.0
.......................   		          X 320,220 0 158,629
1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)...........MediumBullet 20,066,117 0 1,400,772
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet722
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............
3
Yes
 
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........
5
Yes
 
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
TOURMALET ADVISORS

2150 POST ROAD
FAIRFIELD,CT06824 		INVESTMENT MGT 8,603,889
ECHO STREET CAPITAL MGR LLC (VIA HHMI II LLC)

850 THIRD AVENUE
NEW YORK,NY10022 		INVESTMENT MGT 4,641,671
ARAMARK HARRISON LODGING

1101 MARKET ST
PHILADELPHIA,PA19107 		CONFERENCE CTR MGT 4,161,191
WORKDAY INC

6230 STONERIDGE MALL ROAD
PLEASANTON,CA94588 		IT SOFTWARE CONSULTING 3,163,837
THE NORTH HIGHLAND COMPANY

550 PHARR
SUITE 850
ATLANTA,GA30305 		CONSULTANT 2,963,032
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet158
Form 990 (2015)
Form 990 (2015)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII .............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512-514
Contributions, Gifts, GrantAmt and OtherAmt Similar Amounts 1a Federated campaigns..1a  
b Membership dues..1b  
c Fundraising events..1c  
d Related organizations1d  
e Government grants (contributions)1e  
f All other contributions, gifts, grants, and similar amounts not included above1f 19,321,241
g Noncash contributions included in lines 1a-1f:$  
h Total.Add lines 1a-1f.......MediumBullet 19,321,241
Program Service RevenueAmt Business Code
2a RENTAL INCOME 900099 2,169,244 2,169,244    
b TV & Film Royalties 900099 53,918 53,918    
c
d
e
f All other program service revenue. 0 0 0 0
g Total.Add lines 2a–2f.....MediumBullet 2,223,162
OtherAmt RevenueAmt 3 Investment income (including dividends, interest, and othersimilar amounts) ..........MediumBullet 204,038,300   -12,629,452 216,667,752
4 Income from investment of tax-exempt bond proceedsMediumBullet        
5 Royalties...........MediumBullet 256,701,667     256,701,667
(ii) Personal (i) Real
6a Gross rents   767,720
b Less: rental expenses   1,424,636
c Rental income or (loss) 0 -656,916
d Net rental income or (loss)......MediumBullet -656,916   -636,333 -20,583
(ii) Other (i) Securities
7a Gross amount from sales of assets other than inventory 11,432,728 60,406,321,892
b Less: cost or other basis and sales expenses   59,700,068,593
c Gain or (loss) 11,432,728 706,253,299
d Net gain or (loss).....MediumBullet 717,686,027   11,432,728 706,253,299
8a Gross income from fundraising events (not including $   of contributions reported on line 1c). See Part IV, line 18 ....
a  
b Less: direct expenses ...b  
c Net income or (loss) from fundraising events..MediumBullet      
9a Gross income from gaming activities.
See Part IV, line 19 ...
a  
b Less: direct expenses ...b  
c Net income or (loss) from gaming activities..MediumBullet        
10a Gross sales of inventory, less
returns and allowances ..
a  
b Less: cost of goods sold ..b  
c Net income or (loss) from sales of inventory..MediumBullet        
Business Code Miscellaneous Revenue
11a CAFETERIA INCOME 900099 271,442     271,442
b INVESTMENT EXPENSE REBATE 900099 172,767     172,767
c CASH DISCOUNTS 900099 132,378     132,378
d All other revenue .... 430,805 0 0 430,805
e Total. Add lines 11a–11d ...... MediumBullet 1,007,392
12 Total revenue. See Instructions......MediumBullet 1,200,320,873 2,223,162 -1,833,057 1,180,609,527
Form 990 (2015)
Form 990 (2015)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX ..............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising expenses
1 Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 31,593,272 31,593,272
2 Grants and other assistance to individuals in the United States. See Part IV, line 22 86,398,776 86,398,776
3 Grants and other assistance to governments, organizations, and individuals outside the United States. See Part IV, lines 15 and 16 20,801,000 20,801,000
4 Benefits paid to or for members    
5 Compensation of current officers, directors, trustees, and key employees .... 15,274,181 2,453,676 12,820,505  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .... 220,039   220,039  
7 Other salaries and wages 266,923,649 235,196,437 31,727,212  
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 22,662,921 19,940,803 2,722,118  
9 Other employee benefits ....... 115,950,973 99,333,829 16,617,144  
10 Payroll taxes ........... 17,522,408 15,181,179 2,341,229  
11 Fees for services (non-employees):        
a Management ......        
b Legal ......... 3,710,170 2,083,137 1,627,033  
c Accounting ........... 971,762 12,212 959,550  
d Lobbying ...........        
e Professional fundraising services. See Part IV, line 17    
f Investment management fees ...... 67,458,786   67,458,786  
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) 40,629,075 26,043,956 14,585,119 0
12 Advertising and promotion ....        
13 Office expenses ....... 4,826,570 3,550,890 1,275,680  
14 Information technology ...... 9,401,261 659,392 8,741,869  
15 Royalties .. 23,132 6,760 16,372  
16 Occupancy ........... 78,412,496 78,779,948 -367,452  
17 Travel ............ 8,136,399 6,732,161 1,404,238  
18 Payments of travel or entertainment expenses for any federal, state, or local public officials .        
19 Conferences, conventions, and meetings .... 4,072,244 2,713,796 1,358,448  
20 Interest ........... 76,286,215 308,533 75,977,682  
21 Payments to affiliates .......        
22 Depreciation, depletion, and amortization .. 84,426,346 75,119,977 9,306,369  
23 Insurance ... 486,689 164,385 322,304  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a LAB & OTHER SCIENTIFIC SUPPLIES 125,680,795 124,497,069 1,183,726  
b MINOR EQUIPMENT & RENOVATIONS 24,377,408 23,268,389 1,109,019  
c EQUIPMENT MAINTENANCE 16,250,139 14,809,624 1,440,515  
d Income Tax 236,624   236,624  
e All other expenses 10,743,858 10,250,495 493,363 0
25 Total functional expenses. Add lines 1 through 24e 1,133,477,188 879,899,696 253,577,492 0
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2015)
Form 990 (2015)
Page 11
Part X
Balance Sheet
Check if Schedule O contains a response or note to any line in this Part IX ..............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash–non-interest-bearing ........   1  
2 Savings and temporary cash investments ......... 261,159,459 2 331,496,720
3 Pledges and grants receivable, net ......   3  
4 Accounts receivable, net .............   4  
5 Loans and other receivables from current and former officers, directors, trustees, key employees, and highest compensated employees. Complete Part II of Schedule L
  5 0
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), persons described in section 4958(c)(3)(B), and contributing employers and sponsoring organizations of section 501(c)(9) voluntary employees' beneficiary organizations (see instructions) Complete Part II of Schedule L
  6 0
7 Notes and loans receivable, net ....   7  
8 Inventories for sale or use ........   8  
9 Prepaid expenses and deferred charges ...... 12,181,144 9 10,034,921
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 1,787,340,604
b Less: accumulated depreciation 10b 1,048,522,494 761,222,925 10c 738,818,110
11 Investments—publicly traded securities . 7,011,005,370 11 6,611,550,109
12 Investments—other securities. See Part IV, line 11 ..... 13,361,529,118 12 13,078,172,731
13 Investments—program-related. See Part IV, line 11 .. 0 13  
14 Intangible assets ...............   14  
15 Other assets. See Part IV, line 11 ........... 286,638,422 15 312,429,699
16 Total assets. Add lines 1 through 15 (must equal line 34)... 21,693,736,438 16 21,082,502,290
Liabilities 17 Accounts payable and accrued expenses ..... 493,609,336 17 555,985,053
18 Grants payable ... 118,378,619 18 161,167,676
19 Deferred revenue .........   19  
20 Tax-exempt bond liabilities ......... 716,130,000 20 716,130,000
21 Escrow or custodial account liability. Complete Part IV of Schedule D   21  
22 Loans and other payables to current and former officers, directors, trustees, key employees, highest compensated employees, and disqualified
persons. Complete Part II of Schedule L..   22  
23 Secured mortgages and notes payable to unrelated third parties ..   23  
24 Unsecured notes and loans payable to unrelated third parties .. 1,238,405,223 24 1,234,673,954
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17-24). Complete Part X of Schedule D 955,978,144 25 638,986,054
26 Total liabilities. Add lines 17 through 25.. 3,522,501,322 26 3,306,942,737
Net Assets or Fund Balance Organizations that follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 27 through 29, and lines 33 and 34.
27 Unrestricted net assets 18,171,235,116 27 17,775,559,553
28 Temporarily restricted net assets ...........   28  
29 Permanently restricted net assets   29  
Organizations that do not follow SFAS 117 (ASC 958), check here MediumBullet and complete lines 30 through 34.
30 Capital stock or trust principal, or current funds .....   30  
31 Paid-in or capital surplus, or land, building or equipment fund ...   31  
32 Retained earnings, endowment, accumulated income, or other funds   32  
33 Total net assets or fund balances ........... 18,171,235,116 33 17,775,559,553
34 Total liabilities and net assets/fund balances ........ 21,693,736,438 34 21,082,502,290
Form 990 (2015)
Form 990 (2015)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI ..............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
1,200,320,873
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
1,133,477,188
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
66,843,685
4
Net assets or fund balances at beginning of year (must equal Part X, line 33, column (A)) ..
4
18,171,235,116
5
Net unrealized gains (losses) on investments ...............
5
-462,519,248
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
0
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 33, column (B))
10
17,775,559,553
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII .............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
 
No
b
If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.
3b
 
 
Form 990 (2015)
Form 990 (2015)
Additional Data


Software ID: 15000238
Software Version: 2015v3.0
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ.
right arrow Information about Schedule A (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 11, check only one box.)
1
2
3
4

Brigham Womens Hospital,
  ,
Boston, MA  
5
6
7
8
9
10
11
a
b
c
d
e
f
Enter the number of supported organizations ..............  

g
Provide the following information about the supported organization(s).
(i)Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 9 above (see instructions)) (iv) Is the organization listed in your governing document? (v) Amount of monetary support (see instructions) (vi) Amount of other support (see instructions)
Yes No
Total      

For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2011 (b) 2012 (c) 2013 (d) 2014 (e) 2015 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any unusual grants.) ....            
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.......            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3            
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..  
6 Public support. Subtract line 5 from line 4.  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2011 (b) 2012 (c) 2013 (d) 2014 (e) 2015 (f) Total
7 Amounts from line 4..            
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...            
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..            
11 Total support. Add lines 7 through 10.  
12
12
 
13
First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here........................................right arrow
Section C. Computation of Public Support Percentage
14
14
 
15
15
 
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 9 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2011 (b) 2012 (c) 2013 (d) 2014 (e) 2015 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose......            
3 Gross receipts from activities that are not an unrelated trade or business under section 513...            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge..            
6 Total. Add lines 1 through 5.            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons...            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support. (Subtract line 7c from line 6.)  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2011 (b) 2012 (c) 2013 (d) 2014 (e) 2015 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 4
Part IV
Supporting Organizations
(Complete only if you checked a box on line 11 of Part I. If you checked 11a of Part I, complete Sections A and B. If you checked 11b of Part I, complete Sections A and C. If you checked 11c of Part I, complete Sections A, D, and E. If you checked 11d of Part I, complete Sections A and D, and complete Part V.)
Section A. All Supporting Organizations
Yes
No
1
Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.
1
 
 
2
Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).
2
 
 
3a
Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer (b) and (c) below.
3a
 
 
b
Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.
3b
 
 
c
Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.
3c
 
 
4a
Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked 11a or 11b in Part I, answer (b) and (c) below.
4a
 
 
b
Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.
4b
 
 
c
Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.
4c
 
 
5a
Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer (b) and (c) below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).
5a
 
 
b
Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?
5b
 
 
c
Substitutions only. Was the substitution the result of an event beyond the organization's control?
5c
 
 
6
Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.
6
 
 
7
Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ) .
7
 
 
8
Did the organization make a loan to a disqualified person (as defined in section 4958) not described in line 7? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ).
8
 
 
9a
Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.
9a
 
 
b
Did one or more disqualified persons (as defined in line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.
9b
 
 
c
Did a disqualified person (as defined in line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.
9c
 
 
10a
Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.
10a
 
 
b
Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).
10b
 
 
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 5
Part IV
Supporting Organizations (continued)
Yes
No
11
Has the organization accepted a gift or contribution from any of the following persons?
a
A person who directly or indirectly controls, either alone or together with persons described in (b) and (c) below, the governing body of a supported organization?
11a
 
 
b
A family member of a person described in (a) above?
11b
 
 
c
A 35% controlled entity of a person described in (a) or (b) above? If “Yes” to a, b, or c, provide detail in Part VI.
11c
 
 
Section B. Type I Supporting Organizations
Yes
No
1
Did the directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.
1
 
 
2
Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.
2
 
 
Section C. Type II Supporting Organizations
Yes
No
1
Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).
1
 
 
Section D. All Type III Supporting Organizations
Yes
No
1
Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?
1
 
 
2
Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).
2
 
 
3
By reason of the relationship described in (2), did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.
3
 
 
Section E. Type III Functionally-Integrated Supporting Organizations
1
Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):
a
b
c
2
Activities Test. Answer (a) and (b) below.
Yes
No
a
Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.
2a
 
 
b
Did the activities described in (a) constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.
2b
 
 
3
Parent of Supported Organizations. Answer (a) and (b) below.
a
Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations? Provide details in Part VI.
3a
 
 
b
Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.
3b
 
 
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 6
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations
1
Section A - Adjusted Net Income (A) Prior Year (B) Current Year
(optional)
1 Net short-term capital gain 1    
2 Recoveries of prior-year distributions 2    
3 Other gross income (see instructions) 3    
4 Add lines 1 through 3 4    
5 Depreciation and depletion 5    
6 Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) 6    
7 Other expenses (see instructions) 7    
8 Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) 8    

Section B - Minimum Asset Amount (A) Prior Year (B) Current Year
(optional)
1 Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): 1
a Average monthly value of securities 1a    
b Average monthly cash balances 1b    
c Fair market value of other non-exempt-use assets 1c    
d Total (add lines 1a, 1b, and 1c) 1d    
e Discount claimed for blockage or other factors
(explain in detail in Part VI):  
2 Acquisition indebtedness applicable to non-exempt use assets 2    
3 Subtract line 2 from line 1d 3    
4 Cash deemed held for exempt use. Enter 1-1/2% of line 3 (for greater amount, see instructions). 4    
5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5    
6 Multiply line 5 by .035 6    
7 Recoveries of prior-year distributions 7    
8 Minimum Asset Amount (add line 7 to line 6) 8    

Section C - Distributable Amount Current Year
1 Adjusted net income for prior year (from Section A, line 8, Column A) 1  
2 Enter 85% of line 1 2  
3 Minimum asset amount for prior year (from Section B, line 8, Column A) 3  
4 Enter greater of line 2 or line 3 4  
5 Income tax imposed in prior year 5  
6 Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) 6  
7
Schedule A (Form 990 or 990-EZ) 2015

Schedule A (Form 990 or 990-EZ) 2015
Page 7
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations (continued)
Section D - Distributions Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes  
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in
excess of income from activity		  
3 Administrative expenses paid to accomplish exempt purposes of supported organizations  
4 Amounts paid to acquire exempt-use assets  
5 Qualified set-aside amounts (prior IRS approval required)  
6 Other distributions (describe in Part VI). See instructions  
7Total annual distributions. Add lines 1 through 6.  
8 Distributions to attentive supported organizations to which the organization is responsive (provide
details in Part VI). See instructions		  
9 Distributable amount for 2015 from Section C, line 6  
10 Line 8 amount divided by Line 9 amount  

Section E - Distribution Allocations (see instructions) (i)
Excess Distributions 		(ii)
Underdistributions
Pre-2015 		(iii)
Distributable
Amount for 2015
1 Distributable amount for 2015 from Section C, line
6 		 
2 Underdistributions, if any, for years prior to 2015
(reasonable cause required--see instructions)		  
3 Excess distributions carryover, if any, to 2015:
a
b
c
d From 2013.......  
e From 2014.......  
fTotal of lines 3a through e  
g Applied to underdistributions of prior years  
h Applied to 2015 distributable amount  
i Carryover from 2010 not applied (see
instructions)
j Remainder. Subtract lines 3g, 3h, and 3i from 3f.  
4Distributions for 2015 from Section D, line 7:
$  
a Applied to underdistributions of prior years  
b Applied to 2015 distributable amount  
c Remainder. Subtract lines 4a and 4b from 4.  
5 Remaining underdistributions for years prior to
2015, if any. Subtract lines 3g and 4a from line 2
(if amount greater than zero, see instructions)		  
6 Remaining underdistributions for 2015. Subtract
lines 3h and 4b from line 1 (if amount greater than
zero, see instructions)		  
7 Excess distributions carryover to 2016. Add lines
3j and 4c.		  
8 Breakdown of line 7:
a
b
c Excess from 2013.......  
d From 2014.......  
e From 2015.......  
Schedule A (Form 990 or 990-EZ) (2015)

Schedule A (Form 990 or 990-EZ) 2015
Page 8
Part VI
Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Return Reference Explanation
Schedule A (Form 990 or 990-EZ) 2015


Additional Data


Software ID: 15000238
Software Version: 2015v3.0
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors
Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
Arrow Bullet Information about Schedule B (Form 990, 990-EZ, or 990-PF) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ





Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note. Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......... Arrow Bullet $  
Caution. An organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its
Form 990-EZ or on its Form 990PF, Part I, line 2, to certify that it does not meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2015)
Schedule B (Form 990, 990-EZ, or 990-PF) (2015) Page 2
Name of organization
Howard Hughes Medical Institute
  		Employer identification number
59-0735717
Part I
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
 
 

   
 
 
  ,    

$ RESTRICTED


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 

   
 
 

$  


(Complete Part II for noncash contributions.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2015)
Schedule B (Form 990, 990-EZ, or 990-PF) (2015)
Page 3
Name of organization
Howard Hughes Medical Institute
  		Employer identification number

59-0735717
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
(a)
No.from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(see instructions) 		(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2015)
Schedule B (Form 990, 990-EZ, or 990-PF) (2015)
Page 4
Name of organization
Howard Hughes Medical Institute
  		Employer identification number

59-0735717
Part III
Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a)
No.from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No.from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No.from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No.from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2015)

Additional Data


Software ID: 15000238
Software Version: 2015v3.0
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527
SchCMd Bullet Complete if the organization is described below. SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd BulletInformation about Schedule C (Form 990 or 990-EZ) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV.
2
Political expenditures ......................................................................................................................SchCMd Bullet
$  
3
Volunteer hours .............................................................................................................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 ................................SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 .......................SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................
4a
Was a correction made? ......................................................................................................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b...........SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ...................................................................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6
For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2015

Schedule C (Form 990 or 990-EZ) 2015
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
organization's
totals 		(b) Affiliated group totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ...............................................    
b Total lobbying expenditures to influence a legislative body (direct lobbying) ...........................................    
c Total lobbying expenditures (add lines 1a and 1b) .......................................................................    
d Other exempt purpose expenditures .........................................................................................    
e Total exempt purpose expenditures (add lines 1c and 1d) ....................................................................    
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		    
If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
Not over $500,00020% of the amount on line 1e.
Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
Over $17,000,000$1,000,000.
g Grassroots nontaxable amount (enter 25% of line 1f) ..........................................................................    
h Subtract line 1g from line 1a. If zero or less, enter -0-. ..........................................................................    
i Subtract line 1f from line 1c. If zero or less, enter -0-. ...........................................................................    
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ..............................................................................................................

4-Year Averaging Period Under section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
Calendar year (or fiscal year
beginning in) 		(a) 2012 (b) 2013 (c) 2014 (d) 2015 (e) Total
2a Lobbying nontaxable amount          
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		 
c Total lobbying expenditures          
d Grassroots nontaxable amount          
e Grassroots ceiling amount
(150% of line 2d, column (e))		  
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2015


Schedule C (Form 990 or 990-EZ) 2015
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
No
Yes
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? ...........................................................................................................
 
No
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........
 
No
c
Media advertisements? ...................................................................................................
 
No
 
d
Mailings to members, legislators, or the public? .............................................................................
 
No
 
e
Publications, or published or broadcast statements? ...........................................................
 
No
 
f
Grants to other organizations for lobbying purposes? ..........................................................
 
No
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? .......................
 
No
 
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................
 
No
 
i
Other activities? ...................................................................................................................
Yes
 
2,267
j
Total. Add lines 1c through 1i ....................................................................................................
2,267
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
No
b
If "Yes," enter the amount of any tax incurred under section 4912 ...........................................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ...............................................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members ......................................................................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).
a
Current year .............................................................................................................................
2a
 
b
Carryover from last year ............................................................................................................
2b
 
c
Total ...........................................................................................................................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) .........................................
5
 
Part IV
Supplemental Information
Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.
Return Reference Explanation
Schedule C, Part II-B, Line 1 DETAILED DESCRIPTION OF THE LOBBYING ACTIVITY OTHER ACTIVITIES, SCHEDULE C, PART II-B, LINE 1I (OTHER ACTIVITIES) DURING THE FISCAL YEAR, HHMI WAS A MEMBER OF A NUMBER OF NON-PROFIT ORGANIZATIONS THAT ENGAGED IN LOBBYING ACTIVITIES ON BEHALF OF THEIR MEMBERSHIPS. HHMI IS REPORTING AS LOBBYING EXPENDITURES A PORTION OF THE MEMBERSHIP DUES THAT HHMI PAID TO THESE ORGANIZATIONS.
Schedule C, Part II-B, Line 1 DETAILED DESCRIPTION OF THE LOBBYING ACTIVITY OTHER ACTIVITIES, SCHEDULE C, PART II-B, LINE 1I (OTHER ACTIVITIES) DURING THE FISCAL YEAR, HHMI WAS A MEMBER OF A NUMBER OF NON-PROFIT ORGANIZATIONS THAT ENGAGED IN LOBBYING ACTIVITIES ON BEHALF OF THEIR MEMBERSHIPS. HHMI IS REPORTING AS LOBBYING EXPENDITURES A PORTION OF THE MEMBERSHIP DUES THAT HHMI PAID TO THESE ORGANIZATIONS.
Schedule C (Form 990 or 990EZ) 2015


Additional Data


Software ID: 15000238
Software Version: 2015v3.0

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet Attach to Form 990.
Information about Schedule D (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year ....    
2 Aggregate value of contributions to (during year)    
3 Aggregate value of grants from (during year)    
4 Aggregate value at end of year ....    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised
funds are the organization's property, subject to the organization's exclusive legal control? ...........
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be
used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ............................
Part II
Conservation Easements. Complete if the organization answered "Yes" on Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ...................... 2a  
b Total acreage restricted by conservation easements .................... 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 8/17/06, and not on a historic structure listed in the National Register ... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............
6
Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under SFAS 116 (ASC 958), not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under SFAS 116 (ASC 958), to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenue included on Form 990, Part VIII, line 1 .........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under SFAS 116 (ASC 958) relating to these items:
a
Revenue included on Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2015

Schedule D (Form 990) 2015
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b If "Yes," explain the arrangement in Part XIII and complete the following table: Amount
c Beginning balance ............................. 1c  
d Additions during the year ............................ 1d  
e Distributions during the year .......................... 1e  
f Ending balance ................................ 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability?
b
If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ........
Part V
Endowment Funds. Complete if the organization answered "Yes" on Form 990, Part IV, line 10.
(a)Current year (b)Prior year (c)Two years back (d)Three years back (e)Four years back
1a Beginning of year balance ....          
b Contributions ...          
c Net investment earnings, gains, and losses          
d Grants or scholarships ...          
e Other expenditures for facilities
and programs ... 		         
f Administrative expenses ....          
g End of year balance ......          
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Temporarily restricted endowment SchDMd Bullet  
The percentages on lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) unrelated organizations .................
3a(i)
 
 
(ii) related organizations .................
3a(ii)
 
 
b
If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis
(investment) 		(b)Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land ... 807,737 35,488,028 36,295,765
b Buildings 10,248,413 751,765,532 267,784,380 494,229,565
c Leasehold improvements   383,497,469 346,414,306 37,083,163
d Equipment ...   536,521,827 434,323,808 102,198,019
e Other ... 921,448 68,090,150   69,011,598
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..SchDMdBullet 738,818,110
Schedule D (Form 990) 2015

Schedule D (Form 990) 2015
Page 3
Part VII
Investments—Other Securities. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b)Book value (c)Method of valuation:
Cost or end-of-year market value
(1)Financial derivatives    
(2)Closely-held equity interests    
(3)Other
(A) PRIVATE EQUITY & REAL ESTATE 		5,001,889,119 F

(B) DISTRESSED & CREDIT SENSITIVE 		2,259,037,867 F

(C) HEDGED EQUITY 		2,317,213,493 F

(D) MARKET NEUTRAL 		1,283,983,391 F

(E) EQUITY COMMINGLED 		2,216,048,861 F
(E)
(F)
(G)
(H)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet 13,078,172,731
Part VIII
Investments—Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
(1) Federal income taxes  
DERIVATIVE LIABILITIES 1,803,600
SHORT POSITIONS 327,937,043
INVESTMENT PURCH PENDING SALES 39,830,354
CURRENCY EXCH CONTRACTS PAY 3,755,043
CREDIT DEFAULT SWAP  
PAY REALIZED GAINS ON FUTURES 113,838
DEFERRED COMPENSATION LIAB 39,001,217
SWAP UNREALIZED LOSS 219,572,748
INVESTMENT MANAGEMENT FEES PAYABLE 4,424,900
EQUITY SWAP  
DEFERRED INCOME 740,712
INTEREST ON REPURCHASE OBLIGATIONS  
REPURCHASE OBLIGATIONS  
CONTRACT FOR DIFFERENCES LIABILITY 1,806,599
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 638,986,054
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII
Schedule D (Form 990) 2015

Schedule D (Form 990) 2015
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ....... 1 632,634,951
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains (losses) on investments .... 2a -462,519,248
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d 0
e Add lines 2a through 2d ..................... 2e -462,519,248
3 Subtract line 2e from line 1.................. 3 1,095,154,199
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a 106,591,310
b Other (Describe in Part XIII.) ........... 4b -1,424,636
c Add lines 4a and 4b.................... 4c 105,166,674
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 1,200,320,873
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ........... 1 1,028,310,514
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities ......... 2a  
b Prior year adjustments ............ 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d 0
e Add lines 2a through 2d.................... 2e 0
3 Subtract line 2e from line 1................... 3 1,028,310,514
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a 106,591,310
b Other (Describe in Part XIII.) ............ 4b -1,424,636
c Add lines 4a and 4b..................... 4c 105,166,674
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 1,133,477,188

Part XIII
Supplemental Information
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b;
Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Return Reference Explanation
Schedule D, Part XI, Line 4(b) Other revenues in form 990 not in audited financial statements Rental Expenses - -1424636
Schedule D, Part XII, Line 4(b) Other expenses in form 990 not in audited financial statements Rental Expenses - -1424636
Schedule D (Form 990) 2015


Additional Data


Software ID: 15000238
Software Version: 2015v3.0




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990,Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990. Right pointing arrow large image See separate instructions.Right pointing arrow large image Information about Schedule F (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 14b.
1
For grantmakers.Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in region (d) Activities conducted in region (by type) (e.g., fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in region		 (f) Total expenditures
for and investments
in region
Sub-Saharan Africa 0 1 Grantmaking MEDICAL RESEARCH 21,000,000
Sub-Saharan Africa 0 0 Program Services Medical Research 113,932
Europe (Including Iceland and Greenland) 0 0 Grantmaking Investigator Education 21,000
Sub-Saharan Africa 0 0 Investments   41,296,611
North America (Canada & Mexico only) 0 0 Investments   214,473,645
Europe (Including Iceland and Greenland) 0 0 Investments   1,267,663,712
East Asia and the Pacific 0 0 Investments   568,220,903
Central America and the Caribbean 0 0 Investments   6,073,683,993
South America 0 0 Investments   48,225,203
South Asia 0 0 Investments   51,112,999
Middle East and North Africa 0 0 Investments   6,553,062
Russia and Neighboring States 0 0 Investments   4,192,930
Europe (Including Iceland and Greenland) 0 0 Program Services Open Access 3,113,379
           
           
           
           
3a Sub-total ..... 0 1 8,299,671,369
b Total from continuation sheets to Part I ... 0 0 0
c Totals (add lines 3a and 3b) 0 1 8,299,671,369
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2015
Schedule F (Form 990) 2015
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (a)(c) Region (b)(d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount
of non-cash
assistance 		(h) Description
of non-cash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
Europe (Including Iceland and Greenland) EDUCATION IN MEDICAL RESEARCH 21,000 WT      
Sub-Saharan Africa HIV/TB 21,000,000 WT      
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
2
3 Enter total number of other organizations or entities .......................MediumBullet
0
Schedule F (Form 990) 2015
Schedule F (Form 990) 2015Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" to Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
non-cash
assistance 		(g) Description
of non-cash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2015
Schedule F (Form 990) 2015
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes,"the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships. (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713).. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2015
Schedule F (Form 990) 2015
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information (see instructions).
ReturnReference Explanation
Schedule F, Part I, Line 2 Procedures for monitoring use of grant funds During its 2016 fiscal year, HHMI continued to support International Research Scholars selected through one or more competitions open to all eligible applicants. Eligibility requirements included, but were not limited to, a full-time appointment at a nonprofit scientific research organization in a country other than the United States, and a research focus on basic biological processes or disease mechanisms. Qualified applicants were evaluated by a panel of scientific experts with final selections made by HHMI leadership. The disbursement of grant funds to support the work of International Early Career Scientists and Senior International Research Scholars is made in accordance with all applicable U.S. laws. Funds are paid to an institutional account. In order to monitor the activities and productivity of the grants, each scientist is required to submit an annual progress report concerning his or her research and each grantee institution is required to submit annual financial reports. These reports are reviewed by HHMI staff site visits and audits are conducted if warranted and grantees attend scientific meetings of HHMI US-based scientists. In 2009, HHMI helped launch the KwaZulu-Natal Research Institute for TB-HIV (K-RITH) in collaboration with the University of KwaZulu-Natal (UKZN), and has provided significant funding to support its research efforts. As discussed in further detail on Schedule O, in 2016, in a move to improve the health of people locally and globally, K-RITH joined forces with the Africa Centre for Population Health to form a groundbreaking new interdisciplinary institute to fight tuberculosis (TB), HIV and related diseases. The new organization, the Africa Health Research Institute, is located at the heart of South Africa's TB and HIV co-epidemic in KwaZulu-Natal Province. The effort brings together the Africa Centre's detailed population data from over 100,000 participants, with K-RITH's expertise in basic science and its world-class laboratory facilities. The new venture is made possible through grants from HHMI and Wellcome Trust, with the University College London and UKZN as significant academic partners. The Africa Health Research Institute is committed to working towards the elimination of HIV and TB.
Schedule F, Part I, Line 2 PROCEDURES FOR MONITORING USE OF GRANT FUNDS During its 2016 fiscal year, HHMI continued to support International Research Scholars selected through one or more competitions open to all eligible applicants. Eligibility requirements included, but were not limited to, a full-time appointment at a nonprofit scientific research organization in a country other than the United States, and a research focus on basic biological processes or disease mechanisms. Qualified applicants were evaluated by a panel of scientific experts with final selections made by HHMI leadership. The disbursement of grant funds to support the work of International Early Career Scientists and Senior International Research Scholars is made in accordance with all applicable U.S. laws. Funds are paid to an institutional account. In order to monitor the activities and productivity of the grants, each scientist is required to submit an annual progress report concerning his or her research and each grantee institution is required to submit annual financial reports. These reports are reviewed by HHMI staff site visits and audits are conducted if warranted and grantees attend scientific meetings of HHMI US-based scientists. In 2009, HHMI helped launch the KwaZulu-Natal Research Institute for TB-HIV (K-RITH) in collaboration with the University of KwaZulu-Natal (UKZN), and has provided significant funding to support its research efforts. As discussed in further detail on Schedule O, in 2016, in a move to improve the health of people locally and globally, K-RITH joined forces with the Africa Centre for Population Health to form a groundbreaking new interdisciplinary institute to fight tuberculosis (TB), HIV and related diseases. The new organization, the Africa Health Research Institute, is located at the heart of South Africa's TB and HIV co-epidemic in KwaZulu-Natal Province. The effort brings together the Africa Centre's detailed population data from over 100,000 participants, with K-RITH's expertise in basic science and its world-class laboratory facilities. The new venture is made possible through grants from HHMI and Wellcome Trust, with the University College London and UKZN as significant academic partners. The Africa Health Research Institute is committed to working towards the elimination of HIV and TB.
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2015
Additional Data


Software ID: 15000238
Software Version: 2015v3.0



Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990.
lBullet Information about Schedule I (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number
59-0735717
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient
that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government		 (b) EIN (c) IRC section
if applicable		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
non-cash assistance		 (h) Purpose of grant
or assistance
(1) Tuskegee University
Tuskegee University
Tuskegee,AL36088 		63-0288878 501 (c) 3 250,000 0     Undergrad Initiatives
(2) Hope College
Hope College
Holland,MI49423 		38-1381271 501 (c) 3 39,316 0     Undergrad Initiatives
(3) Millsap College
Millsap College
Jackson,MS39210 		64-0303084 501 (c) 3 41,462 0     Undergrad Initiatives
(4) Macalester College
Macalester College
St Paul,MN55105 		41-0693962 501 (c) 3 50,000 0     Undergrad Initiatives
(5) Assoc of American Colleges & Univ
1818 R Street NW
Washington,DC20009 		52-1945674 501 (c) 3 500,000 0     Undergrad Initiatives
(6) Yale University
Yale University
New Haven,CT06520 		06-0646973 501 (c) 3 600,000 0     Ugrad Science Ed
(7) UC - Santa Barbara
UC - Santa Barbara
Santa Barbara,CA93106 		95-6006145 501 (c) 3 50,000 0     Ugrad Science Ed
(8) UC- Los Angeles
UC- Los Angeles
Los Angeles,CA90095 		95-6006143 501 (c) 3 50,000 0     Ugrad Science Ed
(9) Duke University
Duke University
Durham,NC27706 		56-0532129 501 (c) 3 50,600 0     Ugrad Science Ed
(10) Florida International Univ
Florida International Univ
Miami,FL33199 		65-0177616 501 (c) 3 50,000 0     Ugrad Science Ed
(11) Indiana Univ of Pennsylvania
Indiana Univ of Pennsylvania
Indiana,PA15705 		25-1753112 501 (c) 3 1,860,000 0     Ugrad Science Ed
(12) UC - San Francisco
UC - San Francisco
San Francisco,CA94143 		94-6036493 501 (c) 3 19,422 0     EXROP Program - Housing
(13) Travel Expense paid on behalf of grantees-Carl Hotel
198 Carl Street
San Francisco,CA94117 		94-3356764   6,068 0     EXROP Program - Travel
(14) Univ of Washington
Univ of Washington
Seattle,WA98195 		91-6001537 501 (c) 3 7,594 0     EXROP Program - Housing
(15) Travel Expense paid on behalf of grantees-United
233 S Wacker Drive
Chicago,IL60606 		74-2099724   6,103 0     EXROP Program - Travel
(16) Stanford Univ
Stanford Univ
Palo Alto,CA94305 		94-1156365 501 (c) 3 37,035 0     EXROP Program - Housing
(17) Univ of Michigan
Univ of Michigan
Ann Arbor,MI48109 		38-6006309 501 (c) 3 9,593 0     EXROP Program - Housing
(18) Univ of Colorado
Univ of Colorado
Boulder,CO80309 		84-6000555 501 (c) 3 9,518 0     EXROP Program - Housing
(19) Travel Expense paid on behalf of grantees-AMR Corp
4333 Amon Carter Blvd
Fort Worth,TX76155 		75-1825172   8,549 0     EXROP Program - Travel
(20) UC - Berkeley
UC - Berkeley
Berkeley,CA94720 		94-6002123 501 (c) 3 17,060 0     EXROP Program - Housing
(21) Travel Expense paid on behalf of grantees-Delta
PO Box 20706
Atlanta,GA30354 		58-0218548   6,738 0     EXROP Program - Travel
(22) Columbia University
Columbia University
New York,NY10027 		13-5598093 501 (c) 3 18,100 0     EXROP Program - Housing
(23) Rockefeller University
Rockefeller University
New York,NY10065 		13-1624158 501 (c) 3 5,082 0     EXROP Program - Housing
(24) Harvard University
Harvard University
Cambridge,MA02138 		04-2103580 501 (c) 3 63,503 0     EXROP Program - Housing
(25) MIT
MIT
Cambridge,MA02139 		04-2103594 501 (c) 3 18,926 0     EXROP Program - Housing
(26) UC- San Diego
UC- San Diego
La Jolla,CA92093 		95-6006144 501 (c) 3 6,966 0     EXROP Program - Housing
(27) Yale University
Yale University
New Haven,CT06520 		06-0646973 501 (c) 3 14,634 0     EXROP Program - Housing
(28) St Jude's Childrens Research Hospital
262 Danny Thomas Place
Memphis,TN38105 		62-0646012 501 (c) 3 5,143 0     EXROP Program - Housing
(29) UC- Los Angeles
UC- Los Angeles
Los Angeles,CA90095 		95-6006143 501 (c) 3 7,321 0     EXROP Program - Housing
(30) Univ of Texas
Univ of Texas
Austin,TX78712 		74-6000203 501 (c) 3 5,806 0     EXROP Program - Housing
(31) UC - Berkeley
UC - Berkeley
Berkeley,CA94720 		94-6002123 501 (c) 3 51,500 0     University (Doctoral)
(32) Univ of Maryland
Univ of Maryland
Baltimore,MD21201 		52-6002033 501 (c) 3 10,000 0     Minority Serving Inst
(33) Audubon Naturalist Soc
8940 Jones Mill Rd
Chevy Chase,MD20815 		53-0233715 501 (c) 3 53,750 0     Local Inititative
(34) Chesapeake Bay Foundation
162 Prince George St
Annapolis,MD21401 		52-6065757 501 (c) 3 162,500 0     Local Inititative
(35) PG County Public Schools
14201 School Lane
Upper Marlboro,MD20772 		52-6000992 501 (c) 3 41,875 0     Local Inititative
(36) Montgomery Cty PS Educ Found
850 Hungerford Dr
Rockville,MD20850 		52-1804509 501 (c) 3 545,000 0     Local Inititative
(37) Loudoun Cty Public Schools
21000 Education Court
Leesburg,VA20176 		54-6001395 501 (c) 3 1,000,000 0     PreCollege Science - Other
(38) Yale University
Yale University
New Haven,CT06520 		06-0646973 501 (c) 3 30,000 0     Science Education Alliance
(39) Biological Sciences Curriculum Study
CO State Univ
Colorado Springs,CO80918 		84-0622557 501 (c) 3 249,948 0     BSCS NOVA
(40) National Academy of Sciences
2101 Constitution Avenue NW
Washington,DC20001 		53-0196932 501 (c) 3 240,000 0     Science Education
(41) ResearchAmerica
1101 King St Suite 250
Chantilly,VA20153 		52-1609875 501 (c) 3 60,000 0     Program Assessment
(42) Grinnell College
Grinnell College
Grinnell,IA50112 		43-0680387 501 (c) 3 100,000 0     Science Education
(43) UC- Los Angeles
UC- Los Angeles
Los Angeles,CA90095 		95-6006143 501 (c) 3 31,950 0     Science Education
(44) The Conversation US Inc
28 Fairfax St
West Newton,MA02465 		46-0906774 501 (c) 3 500,000 0     Science Journalism
(45) UC - San Diego
UC - San Diego
La Jolla,CA92093 		95-6006144 501 (c) 3 400,000 0     Medical Research
(46) UC - San Francisco
UC - San Francisco
San Francisco,CA94143 		94-6036493 501 (c) 3 124,781 0     Medical Research
(47) CA Inst of Technology
CA Inst of Technology
Pasadena,CA91125 		95-1643307 501 (c) 3 2,061,182 0     Medical Research
(48) NYU
NYU
New York,NY10003 		13-5562308 501 (c) 3 390,970 0     Medical Research
(49) Eastern Mennonite Univ
Eastern Mennonite Univ
Harrisonburg,VA22802 		54-0575812 501 (c) 3 130,000 0     Medical Research
(50) Allen Institute for Brain Science
Allen Institute for Brain Science
Seattle,WA98103 		91-2155317 501 (c) 3 42,847 0     Medical Research
(51) Beth Israel Deaconess Medical Ctr
Beth Israel Deaconess Medical Ctr
Boston,MA02215 		04-2103881 501 (c) 3 400,392 0     Medical Research
(52) Columbia University
Columbia University
New York,NY10027 		13-5598093 501 (c) 3 483,224 0     Medical Research
(53) Duke University
Duke University
Durham,NC27706 		56-0532129 501 (c) 3 1,546,139 0     Medical Research
(54) Fred Hutchinson Cancer Research Ctr
Fred Hutchinson Cancer Research Ctr
Seattle,WA98109 		23-7156071 501 (c) 3 367,652 0     Medical Research
(55) Harvard University
Harvard University
Cambridge,MA02138 		04-2103580 501 (c) 3 250,057 0     Medical Research
(56) Johns Hopkins Univ
Johns Hopkins Univ
Baltimore,MD21218 		52-0595110 501 (c) 3 199,580 0     Medical Research
(57) Massachusetts General Hosp
Massachusetts General Hosp
Boston,MA02129 		04-2697983 501 (c) 3 178,746 0     Medical Research
(58) MIT
MIT
Cambridge,MA02139 		04-2103594 501 (c) 3 987,288 0     Medical Research
(59) Northwestern Univ
Northwestern Univ
Evanston,IL60208 		36-2167817 501 (c) 3 145,608 0     Medical Research
(60) Oregon Health Science Univ
Oregon Health Science Univ
Portland,OR97239 		93-1176109 501 (c) 3 1,708,675 0     Medical Research
(61) Rockefeller University
Rockefeller University
New York,NY10065 		13-1624158 501 (c) 3 263,084 0     Medical Research
(62) Salk Institute
Salk Institute
La Jolla,CA92037 		95-2160097 501 (c) 3 285,996 0     Medical Research
(63) Stanford Univ
Stanford Univ
Palo Alto,CA94305 		94-1156365 501 (c) 3 569,456 0     Medical Research
(64) Univ of Texas
Univ of Texas
Austin,TX78712 		74-6000203 501 (c) 3 455,760 0     Medical Research
(65) UC - Berkeley
UC - Berkeley
Berkeley,CA94720 		94-6002123 501 (c) 3 497,652 0     Medical Research
(66) UC - San Diego
UC - San Diego
La Jolla,CA92093 		95-6006144 501 (c) 3 461,910 0     Medical Research
(67) Univ of Chicago
Univ of Chicago
Chicago,IL60637 		36-2177139 501 (c) 3 368,584 0     Medical Research
(68) Univ of Colorado
Univ of Colorado
Boulder,CO80309 		84-6000555 501 (c) 3 470,191 0     Medical Research
(69) Univ of Florida
Univ of Florida
Gainesville,FL32611 		59-6002052 501 (c) 3 324,262 0     Medical Research
(70) Univ of Massachusetts
Univ of Massachusetts
Worchester,MA01605 		04-3167352 501 (c) 3 249,438 0     Medical Research
(71) Univ of Maryland
Univ of Maryland
Baltimore,MD21201 		52-6002033 501 (c) 3 457,440 0     Medical Research
(72) Univ of Michigan
Univ of Michigan
Ann Arbor,MI48109 		38-6006309 501 (c) 3 458,607 0     Medical Research
(73) Univ of North Carolina
Univ of North Carolina
Chapel Hill,NC27599 		56-6001393 501 (c) 3 216,914 0     Medical Research
(74) Univ of Pennsylvania
Univ of Pennsylvania
Philadelphia,PA19104 		23-1352685 501 (c) 3 1,380,218 0     Medical Research
(75) Univ of Utah
Univ of Utah
Salt Lake City,UT84112 		87-6000525 501 (c) 3 4,302,416 0     Medical Research
(76) Univ of Washington
Univ of Washington
Seattle,WA98195 		91-6001537 501 (c) 3 1,193,516 0     Medical Research
(77) Yale University
Yale University
New Haven,CT06520 		06-0646973 501 (c) 3 276,476 0     Medical Research
(78) Damon Runyon Cancer Research Foundation
Damon Runyon Cancer Res
New York,NY10006 		13-1933825 501 (c) 3 1,412,000 0     Postdoctoral Fellowships
(79) Jane Coffin Childs Memorial Fund for Medical Res
Jane Coffin Childs Mem Fund Med Res
New Haven,CT06510 		06-6034840 501 (c) 3 1,259,922 0     Postdoctoral Fellowships
(80) The Helen Hay Whitney Foundation
The Helen Hay Whitney Foundation
New York,NY10956 		13-1677403 501 (c) 3 1,326,000 0     Postdoctoral Fellowships
(81) Life Sciences Research Foundation
Life Sciences Research Foundation
Baltimore,MD21218 		52-1231801 501 (c) 3 1,472,000 0     Postdoctoral Fellowships
(82) FIU Foundation Inc
11200 SW 8TH ST
Miami,FL33199 		65-0177616 501 (c) 3 10,000 0     UTeach
(83) University of North Texas
1155 UNION CIRCLE
Denton,TX76203 		23-7232618 501(c) 3 10,000 0     UTeach
(84) WKU Research Foundation
1906 COLLEGE HEIGHTS BLVD
Bowling Green,KY42101 		61-1358086 501 (c) 3 10,000 0     UTeach
(85) Drexel University
3141 CHESNUT ST
Philadelphia,PA19104 		23-1352630 501 (c) 3 15,000 0     UTeach
2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image
81
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
4
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2015

Schedule I (Form 990) 2015
Page 2
Part III
Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Number of
recipients		 (c) Amount of
cash grant		 (d) Amount of
non-cash assistance		 (e) Method of valuation (book,
FMV, appraisal, other)		 (f) Description of non-cash assistance
(1) EXROP PROGRAM 105 597,563      
(2) GILLIAM FELLOWSHIPS 92 4,382,406      
(3) SCIENCE EDUCATION FELLOWSHIPS 1 61,919      
(4) INTERNATIONAL PREDOCTORAL FELLOWSHIPS 85 1,963,500      
(5) MEDICAL RESEARCH FELLOWSHIPS 70 2,893,560      
(6) FACULTY SCHOLARS 80 76,500,000      
(6)
(7)
Part IV
Supplemental Information. Provide the information required in Part I, line 2, Part III, column (b), and any other additional information.
Return Reference Explanation
Schedule I, Part I, Line 2 Procedures for monitoring use of grant funds. HHMI awards institutional grants in support of precollege, undergraduate, and graduate education in the US through periodic national competitions for which select institutions are eligible to apply. Each program sets out specific criteria and objectives, proposals are evaluated by a panel of experts with the final selection made by HHMI leadership. The Institute also awards fellowships to international predoctoral students, to medical students seeking to conduct basic laboratory research, and to doctoral students (the Gilliam Fellows). These grants are also awarded on a competitive basis. A small number of grants are awarded based on direct application to HHMI for specific initiatives directly related to science education. The disbursement of funds occurs principally through biomedical research institutions, universities, and colleges. HHMI grantees are required to file annual progress reports that detail expenditures in accordance with the terms of the grant, as well as full description of program activities undertaken with the funds. These are subject to careful review and analysis by HHMI staff with more detailed review by the Institute auditors as warranted. The Institute continues to assess reporting requirements to ensure the quality and timeliness of both financial and programmatic reports. In addition to site visits made by HHMI staff, program directors meet on a regular basis to discuss their activities and share information about best educational practices.
Schedule I (Form 990) 2015



Additional Data


Software ID: 15000238
Software Version: 2015v3.0


Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet Attach to Form 990.
SchJMediumBullet Information about Schedule J (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes in line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .........
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked in line 1a? ..
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed on Form 990, Part VII, Section A, line 1a with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? ................
4a
Yes
 
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.
5
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ...........................
5a
 
No
b
Any related organization?
5b
 
No
If "Yes," on line 5a or 5b, describe in Part III.
6
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization?
6a
 
No
b
Any related organization? .........................
6b
 
No
If "Yes," on line 6a or 6b, describe in Part III.
7
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any non-fixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
Yes
 
8
Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III .............................
8
Yes
 
9
If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
Yes
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2015

Schedule J (Form 990) 2015
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation in column(B) reported as deferred on prior Form 990
(i) Base compensation (ii) Bonus & incentive compensation (iii) Other reportable compensation
1LANDIS ZIMMERMAN
  VP & CHIEF INVESTMENT OFFICER 		(i)

(ii)		 920,705
-------------
0 		2,668,499
-------------
0 		22,020
-------------
0 		26,500
-------------
0 		30,131
-------------
0 		3,667,855
-------------
0 		0
-------------
0
2LAUREN T SPILIOTES ESQ
  DEP GENCOUNSEL/ASST SEC 		(i)

(ii)		 362,685
-------------
0 		0
-------------
0 		19,566
-------------
0 		26,500
-------------
0 		23,052
-------------
0 		431,803
-------------
0 		0
-------------
0
3SUSAN S PLOTNICK
  ASSISTANT TREASURER & DIRECTOR-FINANCE 		(i)

(ii)		 231,847
-------------
0 		3,000
-------------
0 		893
-------------
0 		22,450
-------------
0 		32,751
-------------
0 		290,941
-------------
0 		0
-------------
0
4MONIQUE L MARCUS
  CONTROLLER 		(i)

(ii)		 182,548
-------------
0 		0
-------------
0 		663
-------------
0 		17,930
-------------
0 		27,717
-------------
0 		228,858
-------------
0 		0
-------------
0
5ROBERT TJIAN PHD
  PRESIDENT 		(i)

(ii)		 1,321,750
-------------
0 		10,000
-------------
0 		32,627
-------------
0 		26,500
-------------
0 		45,744
-------------
0 		1,436,621
-------------
0 		0
-------------
0
6CHERYL A MOORE
  EXECUTIVE VP & COO 		(i)

(ii)		 861,067
-------------
0 		10,000
-------------
0 		20,010
-------------
0 		26,500
-------------
0 		21,271
-------------
0 		938,848
-------------
0 		0
-------------
0
7SEAN B CARROLL PHD
  VP FOR SCIENCE EDUCATION 		(i)

(ii)		 659,690
-------------
0 		10,000
-------------
0 		20,864
-------------
0 		26,500
-------------
0 		26,514
-------------
0 		743,568
-------------
0 		0
-------------
0
8HEIDI E HENNING ESQ
  VP,GENERAL COUNSEL/SEC 		(i)

(ii)		 544,821
-------------
0 		0
-------------
0 		20,365
-------------
0 		26,500
-------------
0 		28,242
-------------
0 		619,928
-------------
0 		0
-------------
0
9NITIN V KOTAK
  VP, CFO & TREASURER 		(i)

(ii)		 382,303
-------------
0 		5,000
-------------
0 		19,662
-------------
0 		26,500
-------------
0 		30,653
-------------
0 		464,118
-------------
0 		0
-------------
0
10ERIN K O'SHEA PHD
  VP & CHIEF SCI OFF 		(i)

(ii)		 654,777
-------------
0 		10,000
-------------
0 		88,584
-------------
0 		26,500
-------------
0 		19,098
-------------
0 		798,959
-------------
0 		0
-------------
0
11GERALD M RUBIN PHD
  VP&EXEC DIR,JANELIA RES CAMPUS 		(i)

(ii)		 716,769
-------------
0 		0
-------------
0 		27,716
-------------
0 		26,500
-------------
0 		96,662
-------------
0 		867,647
-------------
0 		0
-------------
0
12KATHY WYSZYNSKI
  VP, HUMAN RESOURCES 		(i)

(ii)		 255,841
-------------
0 		5,000
-------------
0 		19,087
-------------
0 		26,232
-------------
0 		14,300
-------------
0 		320,460
-------------
0 		0
-------------
0
13RICHARD A PENDER
  MAN DIR - US EQUITIES 		(i)

(ii)		 484,903
-------------
0 		471,092
-------------
0 		20,097
-------------
0 		26,500
-------------
0 		27,210
-------------
0 		1,029,802
-------------
0 		0
-------------
0
14ROBERT J KOLYER JR
  MAN DIR - DIVERSIFIED ASSETS 		(i)

(ii)		 425,254
-------------
0 		1,013,297
-------------
0 		20,841
-------------
0 		26,500
-------------
0 		28,273
-------------
0 		1,514,165
-------------
0 		0
-------------
0
15MARK A BARNARD
  MAN DIR - PRIVATE EQUITIES 		(i)

(ii)		 397,407
-------------
0 		860,310
-------------
0 		22,765
-------------
0 		26,500
-------------
0 		31,903
-------------
0 		1,338,885
-------------
0 		0
-------------
0
16STEPHEN M KITSOULIS
  MAN DIR - FIXED INCOME 		(i)

(ii)		 395,673
-------------
0 		505,731
-------------
0 		1,615
-------------
0 		26,500
-------------
0 		20,698
-------------
0 		950,217
-------------
0 		0
-------------
0
17GREGORY DENINNO
  MAN DIR - PRIVATE EQUITIES 		(i)

(ii)		 246,813
-------------
0 		337,799
-------------
0 		2,653
-------------
0 		24,742
-------------
0 		32,254
-------------
0 		644,261
-------------
0 		0
-------------
0
18ANIL MADHOK
  MAN DIR - INVESTMENTS & COO 		(i)

(ii)		 344,377
-------------
0 		756,177
-------------
0 		18,289
-------------
0 		26,500
-------------
0 		14,531
-------------
0 		1,159,874
-------------
0 		0
-------------
0
19DONALD KOCH
  MAN DIR - PORTFOLIO STRATEGY 		(i)

(ii)		 285,829
-------------
0 		674,527
-------------
0 		18,264
-------------
0 		26,500
-------------
0 		32,024
-------------
0 		1,037,144
-------------
0 		0
-------------
0
20THOMAS R CECH PHD
  INVESTIGATOR 		(i)

(ii)		 604,112
-------------
0 		0
-------------
0 		25,618
-------------
0 		26,500
-------------
0 		25,758
-------------
0 		681,988
-------------
0 		0
-------------
0
21RYAN L MATNEY
  DIRECTOR-DIVERSIFIED ASSETS 		(i)

(ii)		 246,409
-------------
0 		338,909
-------------
0 		18,250
-------------
0 		26,019
-------------
0 		30,267
-------------
0 		659,854
-------------
0 		0
-------------
0
22ERIC R KANDEL MD
  SENIOR INVESTIGATOR 		(i)

(ii)		 569,338
-------------
0 		0
-------------
0 		27,567
-------------
0 		26,500
-------------
0 		31,934
-------------
0 		655,339
-------------
0 		0
-------------
0
23MOHAMOUD JIBRELL
  VP FOR INFORMATION TECHNOLOGY 		(i)

(ii)		 179,094
-------------
0 		0
-------------
0 		141,126
-------------
0 		125,994
-------------
0 		32,635
-------------
0 		478,849
-------------
0 		0
-------------
0
Schedule J (Form 990) 2015

Schedule J (Form 990) 2015
Page 3
Part III
Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.
Return Reference Explanation
Schedule J, Part I, Line 1a First-class or charter travel Under HHMI policies, HHMI reimburses its Trustees, President, Vice Presidents, and certain advisory group members for the reasonable cost of airfare at one class above coach for domestic or international flights of three hours or more. If a particular aircraft does not have a business class section, one class above coach may be first class. In this case HHMI would reimburse the traveling Trustee or officer for the reasonable cost of first-class travel if the flight is three hours or more. As an alternative, HHMI may reimburse for the cost of coach airfare plus the cost of an upgrade to travel at one level above coach for a flight of three hours or more. Such travel reimbursements are excluded from taxable compensation in accordance with HHMI's accountable plan. During fiscal year 2016, one key employee, two officers and one trustee flew first class.
Schedule J, Part I, Line 1a Housing allowance or residence for personal use In fiscal year 2016, HHMI's President resided in an HHMI-owned apartment on the headquarters campus, for which he paid HHMI at a fair market rental rate. Because HHMI's President was also required to spend time at HHMI's Janelia campus, where he ran a research laboratory as well as attended meetings and participated in conferences, HHMI made a one-bedroom apartment available to him at that location. HHMI's Vice President and Executive Director, Janelia Research Campus, is required as a condition of employment to reside on the Janelia campus in housing built for that purpose. HHMI's Vice President and Chief Scientific Officer currently resides in an HHMI-owned house on the headquarters campus, for which she pays HHMI at a fair market rental rate. The Institute provides a housing assistance program for one individual who relocated to take a position with HHMI, which may be used to cover such individuals' mortgage or rent payments. In each case, the subsidy is treated as additional taxable compensation.
Schedule J, Part I, Line 4a Severance or change-of-control payment VP for Information Technology - Total severance of $230,160 reported as compensation on Schedule J, Part II (B) iii of $130,666 and reported as deferred compensation on Schedule J, Part II (C) of $99,494.
Schedule J, Part I, Line 7 Non-fixed payments HHMI has an incentive compensation plan for its senior investment staff under which a portion of their compensation is determined based on performance of HHMI's portfolio against market benchmarks. HHMI also makes one-time payments to some of its other employees, including but not limited to officers, in recognition of exceptional performance.
Schedule J, Part I, Line 8 Payments on contract that is subject to the initial contract exception When recruiting individuals for high-level positions, HHMI typically enters into initial contracts. HHMI has entered into initial contracts with its President and a number of Vice Presidents. HHMI's standard practice is to have independent compensation consultants regularly review and confirm the reasonableness of compensation of HHMI's officers and key employees, regardless of whether the initial contract exception applies.
Schedule J (Form 990) 2015
Additional Data


Software ID: 15000238
Software Version: 2015v3.0
Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990.
SchKMediumBulletInformation about Schedule K (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number
59-0735717
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer		 (i) Pool
financing
Yes No Yes No Yes No
A LOUDOUN COUNTY IDA
  		52-1310230 545910AL5 02-27-2003 500,000,000 FINANCE CONSTRUCTION OF JANELIA RESEARCH CAMPUS   X   X   X
B LOUDOUN COUNTY IDA
  		52-1310230 545910AP6 10-02-2009 23,000,000 FINANCE CONSTRUCTION OF JANELIA APT   X   X   X
C LOUDOUN COUNTY IDA
  		52-1310230 545910AQ4 05-15-2013 33,130,000 FINANCE CONSTRUCTION OF JANELIA APT B   X   X   X
D MEDCO
  		52-1376562 574205FY1 02-15-2008 83,500,000 FINANCE CONSTRUCTION OF HQ EXPANSION   X   X   X
MEDCO
  		52-1376562 574205FZ8 05-15-2008 76,500,000 REFUNDING OF ISSUE TO FINANCE HQ CONSTRUCTION   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired .................. 0 0 0 0
2 Amount of bonds legally defeased .............. 0 0 0 0
3 Total proceeds of issue .................. 534,028,000 23,022,042 33,145,417 84,953,297
4 Gross proceeds in reserve funds ............. 0 0 0 0
5 Capitalized interest from proceeds ............. 54,203,000 904,914 1,173,864 5,954,687
6 Proceeds in refunding escrows ............... 0 0 0 0
7 Issuance costs from proceeds ............... 200,000 0 397,311 631,673
8 Credit enhancement from proceeds ............. 0 0 0 0
9 Working capital expenditures from proceeds ............. 0 43,305 0 0
10 Capital expenditures from proceeds ............. 479,625,000 22,073,823 31,574,242 78,366,937
11 Other spent proceeds ............. 0 0 0 0
12 Other unspent proceeds ............. 0 0 0 0
13 Year of substantial completion ............. 2006 2011 2015 2010
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? ....   X   X   X   X
15 Were the bonds issued as part of an advance refunding issue? .....   X   X   X   X
16 Has the final allocation of proceeds been made? .......... X   X   X   X  
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? .................. X   X   X   X  
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............   X   X   X   X
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............   X   X   X   X
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2015

Schedule K (Form 990) 2015
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? ............. X   X   X   X  
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? X   X   X   X  
c Are there any research agreements that may result in private business use of bond-financed property? ............. X     X   X   X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? X              
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....SchKMediumBullet 0 % 0 % 0 % 0 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government ......... SchKMediumBullet 0 % 0 % 0 % 0 %
6 Total of lines 4 and 5 ............. 0 % 0 % 0 % 0 %
7 Does the bond issue meet the private security or payment test? ...   X   X   X   X
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............   X   X   X   X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..        
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............                
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2? ........ 		  X   X   X   X
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ... X     X   X   X
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......       X X     X
b Exception to rebate? ........       X       X
c No rebate due? .........     X       X  
If "Yes" to line 2c, provide in Part VI the date the rebate
computation was performed ......
3 Is the bond issue a variable rate issue? ..... X   X   X   X  
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue? X   X   X   X  
b Name of provider .......... WELLS FARGO
  		JPMORGAN CHASE
  		WELLS FARGO BANK
  		JP MORGAN
 
c Term of hedge ......... 2000 % 3000 % 3000 % 3000 %
d Was the hedge superintegrated? ......   X   X   X   X
e Was the hedge terminated? ........   X   X   X   X
Schedule K (Form 990) 2015

Schedule K (Form 990) 2015
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?   X   X   X   X
b Name of provider ..........  
  		 
  		 
  		 
 
c Term of GIC .........        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........                
6 Were any gross proceeds invested beyond an available temporary period?   X   X   X   X
7 Has the organization established written procedures to monitor the requirements of section 148? ... X   X   X   X  
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?   X   X   X   X
Part VI
Supplemental Information. Provide additional information for responses to questions on Schedule K (see instructions).
Return Reference Explanation
Schedule K, Part I Part I The bond issued February 27, 2003 also includes CUSIPS 545910AM3, 545910AG6, 545910AH4, 545910AJO, and 545910AK7.
Schedule K, Part II, Line 3 Part II, Line 3 - Total Proceeds The bonds issued on 2/27/2003, 10/2/2009, 2/15/2008 and 5/15/2013 included interest income that made up the difference between the amount of the bond issue and the total proceeds.
Schedule K, Part IV Part IV - Name of Provider For the bond issued on 2/27/2003 $375 million notional amount of the $500 million notional amount of swaps pertaining to this bond were integrated. The other counterparties pertaining to the bond issued on 2/27/2003 were Bank of America (30 years), Goldman Sachs (30 years) and JP Morgan (30 years.)
Schedule K, Part IV, Line 4a Part IV, Line 4a Yes, In part for the bonds issued on 2/27/2003, 10/2/2009, 2/15/2008, 5/15/2008 and 5/15/2013.
Schedule K, Part IV, Line 2c COLUMN B Issuer name: LOUDOUN COUNTY IDA The calculation for computing no rebate due was performed on 10/08/2014
Schedule K, Part IV, Line 2c COLUMN D Issuer name: MEDCO The calculation for computing no rebate due was performed on 02/12/2013
Schedule K (Form 990) 2015

Additional Data


Software ID: 15000238
Software Version: 2015v3.0

Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part IV, line 24a. Provide descriptions,
explanations, and any additional information in Part VI.
SchKMediumBullet Attach to Form 990.
SchKMediumBulletInformation about Schedule K (Form 990) and its instructions is at www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number
59-0735717
Part I
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer		 (i) Pool
financing
Yes No Yes No Yes No
A LOUDOUN COUNTY IDA
  		52-1310230 545910AL5 02-27-2003 500,000,000 FINANCE CONSTRUCTION OF JANELIA RESEARCH CAMPUS   X   X   X
B LOUDOUN COUNTY IDA
  		52-1310230 545910AP6 10-02-2009 23,000,000 FINANCE CONSTRUCTION OF JANELIA APT   X   X   X
C LOUDOUN COUNTY IDA
  		52-1310230 545910AQ4 05-15-2013 33,130,000 FINANCE CONSTRUCTION OF JANELIA APT B   X   X   X
D MEDCO
  		52-1376562 574205FY1 02-15-2008 83,500,000 FINANCE CONSTRUCTION OF HQ EXPANSION   X   X   X
MEDCO
  		52-1376562 574205FZ8 05-15-2008 76,500,000 REFUNDING OF ISSUE TO FINANCE HQ CONSTRUCTION   X   X   X
Part II
Proceeds
A B C D
1 Amount of bonds retired .................. 0 0 0 0
2 Amount of bonds legally defeased .............. 0 0 0 0
3 Total proceeds of issue .................. 534,028,000 23,022,042 33,145,417 84,953,297
4 Gross proceeds in reserve funds ............. 0 0 0 0
5 Capitalized interest from proceeds ............. 54,203,000 904,914 1,173,864 5,954,687
6 Proceeds in refunding escrows ............... 0 0 0 0
7 Issuance costs from proceeds ............... 200,000 0 397,311 631,673
8 Credit enhancement from proceeds ............. 0 0 0 0
9 Working capital expenditures from proceeds ............. 0 43,305 0 0
10 Capital expenditures from proceeds ............. 479,625,000 22,073,823 31,574,242 78,366,937
11 Other spent proceeds ............. 0 0 0 0
12 Other unspent proceeds ............. 0 0 0 0
13 Year of substantial completion ............. 2006 2011 2015 2010
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue? ....   X   X   X   X
15 Were the bonds issued as part of an advance refunding issue? .....   X   X   X   X
16 Has the final allocation of proceeds been made? .......... X   X   X   X  
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? .................. X   X   X   X  
Part III
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............   X   X   X   X
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............   X   X   X   X
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2015

Schedule K (Form 990) 2015
Page 2
Part III
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? ............. X   X   X   X  
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? X   X   X   X  
c Are there any research agreements that may result in private business use of bond-financed property? ............. X     X   X   X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? X              
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....SchKMediumBullet 0 % 0 % 0 % 0 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government ......... SchKMediumBullet 0 % 0 % 0 % 0 %
6 Total of lines 4 and 5 ............. 0 % 0 % 0 % 0 %
7 Does the bond issue meet the private security or payment test? ...   X   X   X   X
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............   X   X   X   X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..        
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............                
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2? ........ 		  X   X   X   X
Part IV
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ... X     X   X   X
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......       X X     X
b Exception to rebate? ........       X       X
c No rebate due? .........     X       X  
If "Yes" to line 2c, provide in Part VI the date the rebate
computation was performed ......
3 Is the bond issue a variable rate issue? ..... X   X   X   X  
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue? X   X   X   X  
b Name of provider .......... WELLS FARGO
  		JPMORGAN CHASE
  		WELLS FARGO BANK
  		JP MORGAN
 
c Term of hedge ......... 2000 % 3000 % 3000 % 3000 %
d Was the hedge superintegrated? ......   X   X   X   X
e Was the hedge terminated? ........   X   X   X   X
Schedule K (Form 990) 2015

Schedule K (Form 990) 2015
Page 3
Part IV
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?   X   X   X   X
b Name of provider ..........  
  		 
  		 
  		 
 
c Term of GIC .........        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........                
6 Were any gross proceeds invested beyond an available temporary period?   X   X   X   X
7 Has the organization established written procedures to monitor the requirements of section 148? ... X   X   X   X  
Part V
Procedures To Undertake Corrective Action
A B C D
Yes No Yes No Yes No Yes No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?   X   X   X   X
Part VI
Supplemental Information. Provide additional information for responses to questions on Schedule K (see instructions).
Return Reference Explanation
Schedule K, Part I Part I The bond issued February 27, 2003 also includes CUSIPS 545910AM3, 545910AG6, 545910AH4, 545910AJO, and 545910AK7.
Schedule K, Part II, Line 3 Part II, Line 3 - Total Proceeds The bonds issued on 2/27/2003, 10/2/2009, 2/15/2008 and 5/15/2013 included interest income that made up the difference between the amount of the bond issue and the total proceeds.
Schedule K, Part IV Part IV - Name of Provider For the bond issued on 2/27/2003 $375 million notional amount of the $500 million notional amount of swaps pertaining to this bond were integrated. The other counterparties pertaining to the bond issued on 2/27/2003 were Bank of America (30 years), Goldman Sachs (30 years) and JP Morgan (30 years.)
Schedule K, Part IV, Line 4a Part IV, Line 4a Yes, In part for the bonds issued on 2/27/2003, 10/2/2009, 2/15/2008, 5/15/2008 and 5/15/2013.
Schedule K, Part IV, Line 2c COLUMN B Issuer name: LOUDOUN COUNTY IDA The calculation for computing no rebate due was performed on 10/08/2014
Schedule K, Part IV, Line 2c COLUMN D Issuer name: MEDCO The calculation for computing no rebate due was performed on 02/12/2013
Schedule K (Form 990) 2015

Additional Data


Software ID: 15000238
Software Version: 2015v3.0

SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
MediumBullet Information about Schedule O (Form 990 or 990-EZ) and its instructions is at
www.irs.gov/form990.
OMB No. 1545-0047
2015
Open to Public
Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Return Reference Explanation
Form 990, Part III, Line 4a Program Service Description (continued) (C) HIGHLIGHTS FROM HHMI RESEARCH LABORATORIES (FISCAL YEAR 2016) 1) Study Examines Scale of Gene Mutations in Human Neurons Christopher Walsh, Boston Children's Hospital https://www.hhmi.org/news/study-examines-scale-gene-mutations-human-neurons A single neuron in a normal adult brain likely has more than a thousand genetic mutations that are not present in the cells that surround it, according to research from HHMI scientists. The majority of these mutations appear to arise while genes are in active use, after brain development is complete. 2) High-Speed Microscope Images Entire Living Organisms at High Resolution Philipp Keller, Janelia Research Campus https://www.hhmi.org/news/seeing-big-picture A microscope developed at HHMI's Janelia Research Campus is giving scientists a clearer, more comprehensive view of biological processes as they unfold in living animals. The microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure. What's more, it does so at speeds fast enough to watch cells move as a developing embryo takes shape and to monitor brain activity as it flashes through neuronal circuits. 3) Researchers Identify New Factors that Guide Organization of Plant Roots Philip Benfey, Duke University https://www.hhmi.org/news/researchers-identify-new-factors-guide-organization-plant-roots As the root of a growing plant pushes its way through soil, its cells have a lot of organizing to do. New cells must take on the appropriate identities and positions to form distinct layers of tissue that give the root its structure, protect it from the environment, and ensure that it can properly transport materials to and from the rest of the plant. HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding this tissue formation. The factors, known as the BIRDs, help a root maintain its organization as it grows, guiding several distinct steps in the development of two interior layers of tissue. 4) New Studies Advance Understanding of CRISPR Gene Editing Jennifer Doudna, University of California, Berkeley Robert Tjian, HHMI https://www.hhmi.org/news/new-studies-advance-understanding-crispr-gene-editing CRISPR/Cas9, a defense system that bacteria use to protect against invading genetic elements, was adapted by scientists in 2012 as tool to edit genomes in the lab. The new technology has been adopted enthusiastically by the research community because of its ability to cleave target sequences of DNA with remarkable precision and efficiency. After directly watching individual Cas9 enzymes explore DNA inside living cells, HHMI scientists report that they have a better understanding of how Cas9 speeds through this task, testing out potential targets but quickly moving on from those that are not an exact match. 5) Mutations Before Birth Might Disrupt Heart and Nervous System Development Christine Seidman, Brigham and Women's Hospital Richard Lifton, Yale University https://www.hhmi.org/news/mutations-birth-might-disrupt-heart-and-nervous-system-development A team of scientists has determined why some children who are born with heart defects also often have developmental disabilities such as problems with speech or muscle coordination. The research suggests that these children accrue mutations very early in development that damage genes crucial for heart and brain formation. About one percent of newborns suffer from congenital heart disease, in which structural flaws in the organ, such as misshapen valves or abnormal connections between major vessels, disrupt blood circulation. With surgery or less invasive procedures, doctors can now correct defects that would have killed many of these children 30 years ago. 6) Made in the Shade: How Plants Can Beat the Competition Joanne Chory, The Salk Institute for Biological Studies https://www.hhmi.org/news/made-shade-how-plants-can-beat-competition HHMI research has uncovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth. The scientists found that light-sensing and DNA-binding proteins team up to switch on a unique set of genes that cause a plant to grow. 7) Breakable Genes May Promote Disease and Brain Cell Diversity Frederick Alt, Boston Children's Hospital https://www.hhmi.org/news/breakable-genes-may-promote-disease-and-brain-cell-diversity HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage. The fragility of those genes could explain why they are often mutated or deleted in cancers and neuropsychiatric disorders such as schizophrenia. But their tendency to break could also benefit the brain by providing a way to produce a greater diversity of neurons. 8) New Studies Examine How Mice Respond to a Predator's Scent Linda Buck, Fred Hutchinson Cancer Research Center https://www.hhmi.org/news/new-studies-examine-how-mice-respond-predator-s-scent When the twitching pink nose of a mouse detects danger, the animal has to act fast. Fortunately, a predator rapidly triggers the release of stress hormones in the mouse and prompts behaviors that reduce the risk of it becoming the predator's latest snack. HHMI scientists have identified a brain area that is critical to this instinctive fear response, helping explain how the brain translates danger signals detected by the nose into a physiological response. The research offers clues to the larger puzzle of how animals, including humans, perceive and respond to fear. 9) Command and Control System Monitors Food Intake of Flies Leslie Vosshall, The Rockefeller University https://www.hhmi.org/news/command-and-control-system-monitors-food-intake-flies Working in fruit flies, HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food. To make the decision, neurons in the command center integrate information about an animal's internal state of satiety with taste cues detected just moments after food is swallowed. These neurons simultaneously monitor how hungry the fly is and what the fly is ingesting. Rapid feedback from the cells helps ensure that the insects consume appropriate amounts of nourishing foods. 10) Learning How the Brain Recovers from Disruptions Karel Svoboda and Shaul Druckmann, Janelia Research Campus https://www.hhmi.org/news/learning-how-brain-recovers-disruptions Scientists at HHMI's Janelia Research Campus have found that the brain is organized into modules that work together to maintain critical functions, even in the face of disturbances. This structural organization may explain how neurons that store short-term memories can recover from significant disruptions-for example, enabling a quarterback to remember a planned play despite the distractions he encounters before he throws the football. This organizational motif is likely to underlie other essential circuitry within the brain as well. 11) The Genetic History of Ice Age Europe David Reich, Harvard University https://www.hhmi.org/news/genetic-history-ice-age-europe Analyses of ancient DNA from prehistoric humans paint a picture of dramatic population change in Europe from 45,000 to 7,000 years ago. The new genetic data reveal two big changes in prehistoric human populations that are closely linked to the end of the last Ice Age around 19,000 years ago. As the ice sheet retreated, Europe was repopulated by prehistoric humans from southwest Europe (e.g., Spain). Then, in a second event about 14,000 years ago, populations from the southeast (e.g., Turkey, Greece) spread into Europe, displacing the first group of humans. 12) Staying a Step Ahead of Cancer Kevan Shokat, University of California, San Francisco https://www.hhmi.org/news/staying-step-ahead-cancer HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors. In animal experiments, the drug reduces the size of tumors that are resistant to earlier-generation cancer drugs called mTOR inhibitors. 13) Molecule Required for Pain Also Helps Regulate Body Weight Scott Sternson, Janelia Research Campus https://www.hhmi.org/news/molecule-required-pain-also-helps-regulate-body-weight A molecule best known for its involvement in pain perception also plays an important role in regulating body weight, according to new research in mice by scientists at HHMI's Janelia Research Campus. The molecule, called Nav1.7, enables some neurons to efficiently integrate information they receive over time. When weight-regulating neurons lose this ability, mice become either over- or underweight.
Form 990, Part III, Line 4b Program Service Description (continued) (C) Educational Media HHMI's Educational Media Group is comprised of BioInteractive and Tangled Bank Studios. BioInteractive, a resource for AP biology and college-level introductory biology teachers, has been in existence for more than 15 years and receives 2.5 million unique visitors per year through its website. The Educational Media Group produces science education resources including interactive multimedia materials, scientific animations, videos, in-class activities, the annual Holiday Lectures on Science, as well as award-winning, broadcast-quality short films. The products are then made available to educators online, through the BioInteractive.org website and YouTube channel, and at workshops and conventions. The 2015 Holiday Lectures on Science featured speakers, Robert M Pringle and Corina E Tarnita both from Princeton University, who discussed the "Patterns and Processes in Ecology." The speakers delivered their lectures live to an audience of about 150 high school students from the Washington, DC area. They described their efforts to understand patterns and processes that organize and regulate natural ecosystems. Their lectures were also made available online and will be supplemented by a variety of educational resources, including two "Scientist at Work" videos showing Silliman and Power conducting their research in salt marshes and rivers, respectively. This year, HHMI's Educational Media Group has continued to expand its efforts in translating its educational materials into Spanish and conducting professional development workshops for teachers in Latin American countries in collaboration with the Instituto de Neurociencia Biomedica (BNI), Universidad de Chile, and the Tecnologico de Monterrey, Mexico. The Spanish resources are currently available on the BioInteractive website and on Loligo, a new Spanish-language science education website produced by BNI. HHMI's Educational Media Group also expanded its efforts into citizen science. This year the group launched an educational addition to WildCam Gorongosa, its popular citizen science project that invites participants to identify animals in photos taken by motion-activated trail cameras at Gorongosa National Park (GNP). The new educational tool, called WildCam Lab, allows educators to create virtual classrooms in which students can ask questions and test hypotheses using data from the trail camera project. Students can select subsets of photos according to different criteria, download and sort through data, and share their work with other student. HHMI's Educational Media Group has also started planning a second citizen science project based in Darien National Park in Panama. Finally, HHMI's Educational Media Group will be launching an exciting new app, called BiomeViewer, in which users can explore the climate, vegetation, and wildlife of biomes across the globe. BiomeViewer builds on the success of the popular EarthViewer app which has been downloaded over 1.8 million times. (D) Tangled Bank Studios Tangled Bank Studios, LLC, HHMI's documentary film production unit, is dedicated to the creation of original science documentaries for broadcast, theatrical, and digital distribution. As an extension of HHMI's longstanding science education mission, the company aims to produce programs that capture compelling stories of discovery across all branches of scientific inquiry, with particular focus on the life sciences. Tangled Bank Studios won its first Emmy award, honoring the 2014 three-part PBS series Your Inner Fish. The show won in the Outstanding Graphic Design & Art Direction category in the 37th News & Documentary Emmy Awards competition. Your Inner Fish was a 2014 television series based on the best-selling book by leading paleontologist and evolutionary biologist Neil Shubin, a professor at the University of Chicago. In taking viewers on a cutting-edge, scientific adventure, Your Inner Fish reveals a startling truth: hidden within the human body is a history of life on Earth. Tangled Bank Studios has also produced Mass Extinction-Life at the Brink (Smithsonian Channel 2014) and Vaccines-Calling the Shots (PBS/NOVA 2014). New films released this year: In a new one-hour documentary, WGBH Boston's NOVA team partnered with HHMI's Tangled Bank Studios and Holt Productions to develop, Can Alzheimer's Be Stopped? The film premiered in April 2016 on PBS. Despite the urgent need for treatment, dozens of drug trials to tackle Alzheimer's disease have failed. Less than one percent of Alzheimer's drugs tested have been approved, and none of them can stop the disease. Can Alzheimer's Be Stopped? takes viewers behind the scenes of drug trials to reveal how they are designed, what makes them so challenging, and why researchers are encouraged in their quest for an effective treatment. Spillover - Zika, Ebola & Beyond premiered on PBS in August 2016. Throughout the last few decades, diseases that spill over from animals to humans have been on the rise. What's behind their increase, and can we do anything to combat these dangerous foes? The film follows scientists as they investigate the rise of spillover viruses like Zika, Ebola and Nipah, and learn what science can do to anticipate and prevent epidemics around the world. (E) eLife - Open Access Journal HHMI, together with the Wellcome Trust and the Max Planck Society, continues to support a top tier scientific journal called eLife. The online journal follows an open access model and is directed by practicing scientists. eLife Sciences Publications, Ltd., is an independent non-profit entity governed by a separate board of directors. eLife began publishing research articles in late 2012 and is publishing articles online on a regular basis.
Form 990, Part III, Line 4a Program Service Description (continued-1) 14) Extensive Variation Revealed in 1001 Genomes and Epigenomes of Arabidopsis Joseph Ecker, The Salk Institute for Biological Studies https://www.hhmi.org/news/extensive-variation-revealed-1001-genomes-and-epigenomes-arabidopsis An international team of scientists has sequenced the whole genomes and epigenomes of more than 1,000 Arabidopsis thaliana plants, sampled from geographically diverse locations. The collection of 1,001 genomes and 1,001 epigenomes not only illuminates new aspects of the plant's evolutionary history, but also provides a comprehensive, species-wide picture of the interaction between genetic and epigenetic variation in this important model plant. 15) Large Protein Nanocages Could Improve Drug Design and Delivery David Baker, University of Washington https://www.hhmi.org/news/large-protein-nanocages-could-improve-drug-design-and-delivery Using novel computational and biochemical approaches, scientists have accurately designed and built from scratch 10 large protein icosahedra -- polyhedra with 20 faces -- similar to viral capsids that carry viral DNA. The designed structures are made of two different engineered proteins, present in 60 copies each, which self-assemble into icosahedra. They have a wide variety of potential applications, from targeted drug delivery to the development of more effective vaccines, the researchers say. 16) Gene Tweak Leads to Differences in Drosophila Courtship Songs David Stern, Janelia Research Campus https://www.hhmi.org/news/love-me-do-gene-tweak-leads-differences-drosophila-courtship-songs Pinpointing the precise relationship between genes and behavior has been notoriously tricky for biologists. Janelia Research Campus scientists have devised new strategies to drill down into this link. Using new technologies, a group of Janelia scientists has identified a gene that causes male Drosophila to produce different courtship songs - one sings a high note; the other strikes a low note. The researchers hope the findings and methodology will serve as a roadmap for biologists, allowing them to determine other genetic roots of behavior. (D) Honors and Awards Received by HHMI Scientists (Fiscal Year 2016) Elledge Shares Lasker Award The Albert and Mary Lasker Foundation selected HHMI investigator Stephen Elledge of Brigham and Women's Hospital and Evelyn Witkin of Rutgers University as recipients of the 2015 Albert Lasker Basic Medical Research Award. The Lasker Awards -- considered among the most respected science prizes in the world -- honor visionaries whose insight and perseverance have led to dramatic advances that will prevent disease and prolong life. Elledge and Witkin were honored for discoveries concerning the DNA-damage response -- a fundamental mechanism that protects the genomes of all living organisms. Doudna Receives Canada's Gairdner Award for Research on CRISPR The Gairdner Foundation announced that HHMI Investigator Jennifer Doudna of the University of California, Berkeley is a recipient of the prestigious 2016 Canada Gairdner International Award in recognition of her contributions to medical science. The awards, which are presented annually, recognize scientists responsible for some of the world's most significant medical discoveries. Doudna, who became an HHMI investigator in 1997, was honored for development of CRISPR-Cas9 as a genome-editing tool for eukaryotic cells. HHMI Scientists Elected to The Royal Society HHMI investigators Mark Davis and Jennifer Doudna have been elected to foreign membership in the Royal Society in recognition of their exceptional contributions to science. Fellows and foreign members are elected for contributions to fundamental research as well as for leading scientific and technological progress in industry and research establishments. This year, 50 fellows and 10 foreign members were elected. Deisseroth and Hobbs Awarded Breakthrough Prizes The Breakthrough Prize Foundation selected HHMI investigators Karl Deisseroth of Stanford University and Helen Hobbs of the University of Texas Southwestern Medical Center as recipients of the Breakthrough Prizes in Life Sciences. The prizes honor transformative advances toward understanding living systems and extending human life. Deisseroth was honored for the development and implementation of optogenetics - the programming of neurons to express light-activated ion channels and pumps, so that their electrical activity can be controlled by light. Hobbs was recognized for the discovery of human genetic variants that alter the levels and distribution of cholesterol and other lipids, inspiring new approaches to the prevention of cardiovascular and liver disease. The Breakthrough Prizes recognize pioneering work in physics and genetics, cosmology, and neurology and mathematics. Each prize carries an award of $3 million. Zoghbi Awarded Shaw Prize The Shaw Prize Foundation in Hong Kong announced that Huda Zoghbi, a Howard Hughes Medical Institute investigator at Baylor College of Medicine, and Adrian Bird of the University of Edinburgh will share the $1.2 million award for their discovery of the genes and proteins involved in the developmental disorder Rett syndrome. The Shaw Prize consists of three annual awards in astronomy, life science and medicine, and mathematical sciences. These international awards honor individuals who have achieved distinguished breakthroughs in academic and scientific research. The awards are dedicated to furthering societal progress, enhancing quality of life, and enriching humanity's spiritual civilization. Five HHMI Researchers Elected to National Academy of Medicine Five HHMI researchers have been elected to the National Academy of Medicine (NAM). The HHMI scientists are among 70 new NAM members and 10 international members elected today. Established originally as the Institute of Medicine in 1970 by the National Academy of Sciences, the National Academy of Medicine addresses critical issues in health, science, medicine, and related policy and inspires positive actions across sectors. The new members are HHMI investigators, Michael Green, University of Massachusetts School of Medicine; Nikola Pavletich, Memorial Sloan Kettering Cancer Center; Alexander Rudensky, Memorial Sloan Kettering Cancer Center; Jean-Laurent Casanova, The Rockefeller University; and HHMI Senior International Research Scholar, Nahum Sonenberg, McGill University. HHMI Scientists Elected to National Academy of Sciences Eleven Howard Hughes Medical Institute scientists were elected to membership in the National Academy of Sciences. They are among 84 new members and 21 foreign associates from 15 countries elected in recognition of their distinguished and continuing achievements in original research. The National Academy of Sciences is a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. The scientists are Joseph DeRisi, University of California, San Francisco; Raymond Deshaies, California Institute of Technology; Nathaniel Heintz, The Rockefeller University; Hopi Hoekstra, Harvard University; Kenneth Murphy, Washington University in St. Louis; Krishna Niyogi, University of California, Berkeley; David Sabatini, Whitehead Institute for Biomedical Research; Amita Sehgal, University of Pennsylvania; Geraldine Seydoux, The Johns Hopkins University; Michael Summers, University of Maryland, Baltimore County; Bonnie Bartel, Rice University.
Form 990, Part VI, Line 11b Review of form 990 by governing body The Howard Hughes Medical Institute's Form 990 is initially prepared by its Tax Compliance Department, in coordination with other HHMI departments as needed. The draft return is reviewed by senior management of HHMI and by attorneys in HHMI's Office of the General Counsel. Following these reviews and the resolution of any questions that have been raised, the draft return is reviewed by HHMI's outside tax preparer. Finally, a copy of the return is provided to the members of HHMI's Board of Trustees so that they have an opportunity to review and comment on the return before it is filed.
Form 990, Part VI, Line 12c Conflict of interest policy In addition to HHMI's code of conduct, which addresses conflicts of interest and applies to all HHMI employees, officers, Trustees, and advisors, HHMI has specific conflict of interest policies for different categories of personnel. Under the HHMI policies that apply to Trustees, officers, and key employees, these individuals must disclose annually interests that could give rise to conflicts of interest, and must certify annually their compliance with the conflict of interest policy that applies to them. Annual disclosures and certifications are reviewed by HHMI's Office of the General Counsel, and by other HHMI managers as needed. The conflict of interest policy covering HHMI's Trustees also requires each Trustee to disclose to the other Trustees any actual or apparent conflict of interest with respect to a proposed HHMI transaction. If the other Trustees decide that there is only the appearance of a conflict of interest, and that it could not reasonably be considered to affect the independent, unbiased judgment of the disclosing Trustee with respect to the transaction at issue, no further action is required to address the apparent conflict. In all other cases, including all actual conflicts of interest, the disclosing Trustee is not permitted to participate in the deliberation or decision regarding the transaction under consideration, and must leave the room during the deliberation and vote. The conflict of interest policies covering HHMI's officers and key employees require each covered individual to obtain supervisory approval up to the level of HHMI's President before entering into an affiliation with or acquiring an interest of 1% or more in any entity that is or may become a recipient of HHMI funds. HHMI's President, in consultation with HHMI's General Counsel, may permit the affiliation or interest if it would not interfere with the covered individual's performance of his or her HHMI responsibilities, would not create the appearance of a conflict of interest, and would be consistent with sound business judgment. HHMI's President may set conditions on approval, for example that there be no remuneration to the covered individual. Proposed affiliations and interests of 1% or more of HHMI's President are subject to the approval of the Chairman of the Trustees.
Form 990, Part VI, Line 15a Process to establish compensation of top management official The compensation for HHMI's President, other officers, and key employees is set using the following procedures: Every other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent compensation consultants to conduct a study of comparable market data. The study includes data for HHMI's President, other officers, and key employees. The independent compensation consultants also provide an opinion regarding the reasonableness of the compensation arrangements for the positions included in the study. The study includes comparable market data for all components of compensation for each person covered by the study, including base salary, incentive compensation (if any), and benefits. The Committee relies on the market data and opinion provided by the compensation consultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers and key employees. The decision is made by independent Trustees. Any Trustee who has a conflict of interest with respect to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, and leave the meeting room during the debate and voting on it. In the alternate years when a study is not done, the Audit and Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit increases for HHMI employees, including senior management, is reasonable compared with generally prevailing compensation increases in the market over the past year. The Committee relies on this advice in recommending compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in making compensation decisions. Recusal procedures are the same as in the years when a study is done. In each year, minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for approval at the next meeting. Approved minutes are kept in HHMI's records. All minutes include the date of the meeting, identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees with a conflict of interest. The comparability studies and opinions relied on at the meeting are referenced in the minutes, and copies of these materials are also kept in HHMI's records. HHMI's Board of Trustees followed this process in August 2015 in determining compensation for the following positions for fiscal year 2016: President, Vice Presidents, and Managing Directors - Investments.
Form 990, Part VI, Line 15b Process to establish compensation of other employees The compensation for HHMI's President, other officers, and key employees is set using the following procedures: Every other year, the Audit and Compensation Committee of HHMI's Board of Trustees engages one or more independent compensation consultants to conduct a study of comparable market data. The study includes data for HHMI's President, other officers, and key employees. The independent compensation consultants also provide an opinion regarding the reasonableness of the compensation arrangements for the positions included in the study. The study includes comparable market data for all components of compensation for each person covered by the study, including base salary, incentive compensation (if any), and benefits. The Committee relies on the market data and opinion provided by the compensation consultant in making recommendations to the Board of Trustees regarding compensation for HHMI's President, other officers and key employees. The decision is made by independent Trustees. Any Trustee who has a conflict of interest with respect to a specific officer or key employee must recuse himself or herself from the decision on that person's compensation, and leave the meeting room during the debate and voting on it. In the alternate years when a study is not done, the Audit and Compensation Committee confirms with the independent compensation consultants that the range of any proposed merit increases for HHMI employees, including senior management, is reasonable compared with generally prevailing compensation increases in the market over the past year. The Committee relies on this advice in recommending compensation for HHMI's President, other officers and key employees, and the Board of Trustees relies on this advice in making compensation decisions. Recusal procedures are the same as in the years when a study is done. In each year, minutes of the discussions and decisions regarding compensation are prepared after each meeting and are submitted for approval at the next meeting. Approved minutes are kept in HHMI's records. All minutes include the date of the meeting, identify those Trustees who attended and voted on the compensation arrangements, and note any recusals of Trustees with a conflict of interest. The comparability studies and opinions relied on at the meeting are referenced in the minutes, and copies of these materials are also kept in HHMI's records. HHMl's Board of Trustees followed this process in August 2015 in determining compensation for the following positions for fiscal year 2016: President, Vice Presidents, and Managing Directors - Investments.
Form 990, Part VI, Line 19 Required documents available to the public HHMI's practice has been to make a copy of its charter and by-laws available on request. HHMI's code of conduct, which addresses conflicts of interest, is available to the public on the HHMI website. A downloadable copy of HHMI's most recent audited financial statements is also available to the public on the website. In addition, HHMI publishes "Year in Review" that provides a summary of each year's activity, expenditures, and financial performance.
Form 990, Part VIII, Line 11d Other Miscellaneous Revenue Miscellaneous - Total Revenue: 313443, Related or Exempt Function Revenue: , Unrelated Business Revenue: , Revenue Excluded from Tax Under Sections 512, 513, or 514: 313443; Innovation Dissemination - Total Revenue: 117362, Related or Exempt Function Revenue: , Unrelated Business Revenue: , Revenue Excluded from Tax Under Sections 512, 513, or 514: 117362;
Schedule A, Part I, Line 4 List of Hospital Affiliations List of hospital affiliations for e-filing: Hospital, City, State, Zip Code- B&W Hospital, Boston, MA, 02115/ Children's Hosp, Boston, MA, 02115/ Children's Hosp, Cincinnati, OH, 45229/ Dana-Farber, Boston, MA, 02115/ Fred Hutch, Seattle, WA, 98109/ JHopkins Hosp, Baltimore, MD, 21205/ Mass Gen Hosp, Boston, MA, 02129/ MSKCC, New York, NY, 10021/ Nat'l Jewish, Denver, CO, 80206/ St Jude, Memphis, TN, 38105/ Duke-Duke Hosp, Durham, NC, 27706/ NYU-NYU Hosps, New York, NY, 10016/ OHSU-OHSU Hosp, Portland, OR, 97239/ Rockefeller-Hosp, New York, NY,10021/ Penn State Univ-Hosp, University Park, PA 16802/ Stanford-Hosp, Palo Alto, CA, 94305/ UCLA-Med Ctr, Los Angeles, CA, 90095/ UCSD-Med Ctr, San Diego, CA, 92093/ UCSF-UCSF Hosps, San Francisco, CA, 94143/ UIowa-UIowa Hosps, Iowa City, IA, 52242/ UMass-Med Ctr, Worcester, MA, 01605/ UMich-UMich Hosp, Ann Arbor, MI, 48109/ UPenn-UPenn Hosp, Philadelphia, PA, 19104/ UT-Austin-UT Hosp, Austin, TX, 78712/ UTSW-UTSW Hosps, Dallas, TX, 75390/ UUtah-UUtah Hosps, Salt Lake City, UT, 84112/ UWash-Med Ctr, Seattle, WA, 98195/ ADARC-aff hosp, New York, NY, 10016/ AECOM-affil hosps, New York, NY, 10461/ Baylor-aff hosps, Houston, TX, 77O3O/ BU-aff hosp, Boston, MA, 02126/ Brandeis-aff hsps, Waltham, MA, 02254/ CalTech-aff hosps, Pasadena, CA, 91125/ Carnegie-aff hsps, Baltimore, MD, 21210/ CSHL-affil hosps, Cold Spring Harbor, NY, 11724/ CSU-affil hosp, Fort Collins, CO, 80521/ Columbia-aff hsps, New York, NY, 10027/ Cornell-aff hosps, New York, NY, 14853/ Harvard-aff hosps, Cambridge, MA, 02138/ Indiana-affil hosp, Bloomington, IN, 47405/ TJL-affil hosps, Bar Harbor, ME, 04609/ JHU-affil hosps, Baltimore, MD, 21218/ MichSU-affil hosps, Lansing, MI, 48824/ MIT-affil hosps, Boston, MA, 02139/ NWU-affil hosps, Evanston, IL, 60208/ Princeton-aff hosps, Princeton, NJ, 08544/ Rutgers-affil hosp, Piscataway, NJ, 08854/ Salk-affil hosps ,La Jolla, CA, 92093/ Scripps-affil hosps, La Jolla, CA 92037/ Stowers-aff hosps, Kansas City, MO, 64110/ SUNY-affil hosps, Stony Brook, NY,11794/ Texas A&M-aff hsp, College Station, TX, 77843/ Tufts-aff hosps, Boston, MA, 02111/ UCB-affil hosps, Berkeley, CA, 94720/ UCDavis-affil hsps, Davis, CA, 95616/ UCR-affil hosps, Riversde, CA, 92521/ UCSC-aff hosps, Santa Cruz, CA, 95064/ UChi-affil hosp, Chicago, IL, 60637/ UColo-aff hosp, Boulder, CO, 80309/ UColo-aff hosp, Denver, CO, 80217/ Uillinois-aff hsp, Urbana, IL, 61801/ UMD-affil hosp, Baltimore, MD, 21201/ UMN-affil hosp, Minneapolis, MN 55414/ UNC-affil hosps, Chapel Hill, NC, 27599/ UOregon-aff hsp, Eugene, OR,97403/ UWisc-affil hosps, Madison, WI, 53706/ WashU-aff hosp, St Louis, MO, 63130/ YaleU-affil hosp, New Haven, CT, 06520/
Schedule A, Part I, Line 4 MRO Qualification The Institute is a medical research organization for its taxable year ended August 31, 2016, as its expenditures of $ 791,795,075 on a cash basis for the year ended August 31 , 2015 exceeded the MRO requirement of $727,119,083 (3.5% of the HHMI endowment).
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2015


Additional Data


Software ID: 15000238
Software Version: 2015v3.0
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBulletAttach to Form 990.
MediumBullet Information about Schedule R (Form 990) and its instructions is at www.irs.gov/form990.

OMB No. 1545-0047
2015
Open to Public Inspection
Name of the organization
Howard Hughes Medical Institute
 
Employer identification number

59-0735717
Part I
Identification of Disregarded Entities Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income


 		(e)
End-of-year assets


 		(f)
Direct controlling
entity
(1) HHMI II LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 7,482,899 515,652,860 HHMI
 
(2) HHMI IV LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(3) HHMI V LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(4) HHMI XII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(5) HHMI XVI LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE -7,196,998 369,516,766 HHMI
 
(6) SPRUGOS INVESTMENTS II LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(7) SPRUGOS INVESTMENTS V LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 8,776,795 61,472,990 HHMI
 
(8) SPRUGOS INVESTMENTS VII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 28,076,355 229,778,026 HHMI
 
(9) SPRUGOS INVESTMENTS VIII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 33,383,422 218,197,977 HHMI
 
(10) SPRUGOS INVESTMENTS X LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(11) SPRUGOS INVESTMENTS XI LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 22,917,767 70,480,415 HHMI
 
(12) SPRUGOS INVESTMENTS XII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 8,943 108,933 HHMI
 
(13) SPRUGOS INVESTMENTS XIII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(14) PRIVATE EQUITY HOLDING LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(15) PRIVATE EQUITY HOLDING-AHEAD LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 394 0 HHMI
 
(16) PRIVATE EQUITY HOLDING-ALEXA LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE -2,593 0 HHMI
 
(17) PRIVATE EQUITY HOLDING-CS CAPITAL LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE -467,856 0 HHMI
 
(18) PRIVATE EQUITY HOLDING-EUROCASTLE LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE -360,168 2,635,439 HHMI
 
(19) PRIVATE EQUITY HOLDING-FAVRILLE LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(20) PRIVATE EQUITY HOLDING-KAP LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(21) PRIVATE EQUITY HOLDING-ROYCE LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(22) PRIVATE EQUITY HOLDING-STORERETRO LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(23) PRIVATE EQUITY HOLDING-XENOPORT LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(24) HHMI FI I LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(25) JANELIA FARM HOLDING LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT VA 0 0 HHMI
 
(26) SELDEN ISLAND HOLDING LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT VA 0 0 HHMI
 
(27) HHMI I LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(28) HHMI III LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(29) HHMI VI LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(30) HHMI VII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE -787,782 107,909,665 HHMI
 
(31) HHMI VIII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(32) HHMI IX LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(33) HHMI X LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(34) HHMI XI LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(35) HHMI XIII LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(36) HHMI XIV LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(37) HHMI XV LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(38) SPRUGOS INVESTMENTS LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(39) SPRUGOS INVESTMENTS III LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 17,380,556 324,995,022 HHMI
 
(40) SPRUGOS INVESTMENTS IV LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(41) SPRUGOS INVESTMENTS VI LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(42) SPRUGOS INVESTMENTS IX LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 10,396,721 330,002,477 HHMI
 
(43) SPRUGOS-FRENCH LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(44) PRIVATE EQUITY HOLDING II LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(45) PRIVATE EQUITY HOLDING III LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(46) RELATIVE VALUE STRATEGIES LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(47) PSG LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 INVESTMENT DE 0 0 HHMI
 
(48) HHMI-SA LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 RESEARCH DE 0 161,606 HHMI
 
(49) TANGLED BANK STUDIOS LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
 FILM PROD DE 0 0 HHMI
 
(50) MISSING LINK PRODUCTIONS LLC
4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
47-1329820 		FILM PROD DE 0 126 HHMI
 
(51) LSV ADVANTAGE INTL III (CAYMAN) LTD
89 NEXUS WAY 2/F CANAMA BAY
  GRAND CAYMANKY11205
CJ
98-0689621 		INVESTMENT CJ -789,734 27,196,419 HHMI
 
(52) LSV ADVANTAGE INTL III-B (CAYMAN) LTD
89 NEXUS WAY 2/F CAMANA BAY
  GRAND CAYMANKY11205
CJ
98-1087158 		INVESTMENT CJ 17,713,772 97,058,358 HHMI
 
Part II
Identification of Related Tax-Exempt Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section


 		(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled entity?
Yes No












For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2015
Schedule R (Form 990) 2015
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a partnership during the tax year.
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V-UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No
(1) CERBERUS HH PARTNERS LP

190 ELGIN AVENUE
GEORGETOWN   KY19005
CJ
98-1102879 		INVESTMENT CJ HHMI
  		Excluded 9,709,626 142,748,880   No 0   No 95 %
(2) GEM NPL CO-INV FUND LP

900 NORTH MICHIGAN AVENUE SUITE 14
SUITE 1450
CHICAGO,IL60611
46-4232021 		INVESTMENT IL HHMI
  		Excluded 2,241 1,607,918   No -223,424   No 67 %
(3) HHLF LP

555 5TH AVENUE FL18
NEW YORK,NY10017
46-2823996 		INVESTMENT NY HHMI
  		Excluded 6,348,363 31,437,374   No 0   No 94 %
(4) LUMINUS CREDIT OPPORTUNITIES PIE I LP

1700 BROADWAY 38TH FLOOR
NEW YORK,NY10019
26-1963557 		INVESTMENT NY HHMI
  		Excluded 1,924,728 45,845,840   No 0   No 99 %
(5) SOLUS OPPORTUNITIES FUND 2 LP

410 PARK AVENUE 11TH FLOOR
NEW YORK,NY10022
46-3541945 		INVESTMENT NY HHMI
  		Excluded 7,354,072 61,023,991   No 0   No 98 %
(6) CVI HH INVESTMENTS LP

9320 EXCELSIOR BLVD
MS144-7-2
HOPKINS,MN55343
90-1010136 		INVESTMENT MN HHMI
  		Excluded 3,175,407 289,352,589   No 0   No 100 %
(7) ECHO STREET GOODCO SELECT II LP

10 EAST 53RD STREET
32ND FLOOR
NEW YORK,NY10022
47-4827277 		INVESTMENT NY HHMI
  		Excluded 2,364,778 105,905,868   No 0   No 100 %
(8) GEM BVP CO-INV-A LP

900 NORTH MICHIGAN AVENUE
SUITE 1450
CHICAGO,IL60611
47-2251559 		INVESTMENT IL HHMI
  		Excluded 0 7,075,267   No 0   No 100 %
(9) HH HOLDCO CO-INVESTMENT FUND LP

32 BROADWAY SUITE 1201
NEW YORK,NY10004
30-0864915 		INVESTMENT NY HHMI
  		Excluded 371,467 69,391,381   No 0   No 99.478 %
(10) HH SG SECONDARY FUND LP

825 THIRD AVENUE
10TH FLOOR
NEW YORK,NY10022
47-3358493 		INVESTMENT NY HHMI
  		Excluded 1,490,738 15,847,917   No 0   No 94 %
(11) TOURMALET MATAWIN OFFSHORE FUND VI-A LP

89 NEXUS WAY CAMANA BAY
  GRAND CAYMANKY19007
CJ
INVESTMENT CJ HHMI
  		Excluded 2,364,893 35,066,543   No 0   No 100 %
(12) HH ELLINGTON MASTER FUND LTD

53 FOREST AVENUE
OLD GREENWICH,CT06870
98-1020904 		INVESTMENT CT HHMI
  		Excluded 12,566,556 30,037,303   No 0   No 82 %
Part IV
Identification of Related Organizations Taxable as a Corporation or Trust Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.
(a)
Name, address, and EIN of
related organization
 		(b)
Primary activity
 		(c)
Legal
domicile
(state or foreign
country)
 		(d)
Direct controlling
entity
 		(e)
Type of entity
(C corp, S corp,
or trust) 		(f)
Share of total income
 		(g)
Share of end-of-year
assets
 		(h)
Percentage
ownership
 		(i)
Section 512(b)(13) controlled entity?
Yes No
(1) HHMI REAL ESTATE INC

4000 JONES BRIDGE ROAD
CHEVY CHASE,MD20815
20-3967202 		INVESTMENT DE HHMI
  		C Corporation 20,439 1,668,550 100 % Yes  
(2) PLEASANT VALLEY INVESTMENTS LP

99 QUEENS ROAD CENTRAL
UNIT 2112 21/F THE CENTER
HONG KONG    
HK
98-0586696 		INVESTMENT CJ HHMI
  		C Corporation 4,608,493 26,622,556 51 % Yes  
(3) HH ELLINGTON FUND LTD

WALKER HOUSE 87 MARY STREET
GEORGETOWN,GRKY19005
CJ
INVESTMENT CJ HHMI
  		C Corporation 12,566,556 30,037,303 100 % Yes  
(4) SPRUGOS MAURITIUS I LTD

33 EDITH CAVELL STREET
PORT LOUIS    
MP
INVESTMENT MP HHMI
  		C Corporation 6,775,987 29,127,898 100 % Yes  
(5) HHMI CAYMAN I COMPANY

WALKER WALKER HOUSE MARY STREET
PO BOX 265GT
GEORGETOWN    
CJ
INVESTMENT CJ HHMI
  		C Corporation -24,913 311,021 100 % Yes  
(6) CHALKSTREAM KOREA FUND INTERNATIONAL LP

27 Hospital Road
George Town,Grand CaymanKY19008
CJ
98-1248058 		INVESTMENT CJ HHMI
  		C Corporation -5,000,309 44,624,449 100 % Yes  
(7) LSV ADVANTAGE INTERNATIONAL III LTD

89 NEXUS WAY 2/F CAMANA BAY
  GRAND CAYMANKY11205
CJ
98-1300995 		INVESTMENT CJ HHMI
  		C Corporation 84,458 3,982,159 100 % Yes  
(8) LSV ADVANTAGE INTERNATIONAL III-B LTD

89 NEXUS WAY 2/F CAMANA BAY
  GRAND CAYMANKY11205
CJ
98-1315328 		INVESTMENT CJ HHMI
  		C Corporation 2,420,501 14,462,081 100 % Yes  
(9) COASTLAND RELATIVE VALUE FUND LTD

WALKER HOUSE 87 MARY STREET
GEORGE TOWN,GRAND CAYMANKY19005
CJ
INVESTMENT CJ HHMI
  		C Corporation 15,533,287 97,841,370 70 % Yes  
(10) IRONSIDES PARTNERS SPECIAL SITUATIONS OFFSHORE FUND LTD

PO BOX 309 UGLAND HOUSE
  GRAND CAYMAN11104
CJ
INVESTMENT CJ HHMI
  		C Corporation 43,289 9,887,435 58 % Yes  
(11) MARSHALL WACE MANAGED ACCOUNTS PLC-MW EUROPA FUND II

BEAUX LANE HOUSEMERCER ST LOWER
DUBLIN   2
EI
INVESTMENT EI HHMI
  		C Corporation 21,718,331 168,665,556 100 % Yes  
(12) NEWFOUNDLAND TERRANOVA OFFSHORE FUND

89 NEXUS WAY CAMANA BAY
  GRAND CAYMANKY19007
CJ
INVESTMENT CJ HHMI
  		C Corporation -11,854,539 111,953,942 82 % Yes  
Schedule R (Form 990) 2015
Schedule R (Form 990) 2015
Page 3
Part V
Transactions With Related Organizations Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................
1a
 
No
b Gift, grant, or capital contribution to related organization(s) ............................
1b
Yes
 
c Gift, grant, or capital contribution from related organization(s) ............................
1c
 
No
d Loans or loan guarantees to or for related organization(s) ............................
1d
 
No
e Loans or loan guarantees by related organization(s) ............................
1e
 
No
f Dividends from related organization(s) ............................
1f
 
 
g Sale of assets to related organization(s) ............................
1g
 
No
h Purchase of assets from related organization(s) ............................
1h
 
No
i Exchange of assets with related organization(s) ............................
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) .......................
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) ......................
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) .....................
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) .................
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................
1n
 
No
o Sharing of paid employees with related organization(s) ............................
1o
 
No
p Reimbursement paid to related organization(s) for expenses ............................
1p
 
No
q Reimbursement paid by related organization(s) for expenses ............................
1q
 
No
r Other transfer of cash or property to related organization(s) ............................
1r
 
No
s Other transfer of cash or property from related organization(s) ............................
1s
Yes
 
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of related organization 		(b)
Transaction
type (a-s) 		(c)
Amount involved 		(d)
Method of determining amount involved
(1) CERBERUS HH PARTNERS LP

 B 33,998,371 FMV
(2) CVI HH INVESTMENTS LP

 B 80,000,000 FMV
(3) ECHO STREET GOODCO SELECT II LP

 B 100,000,000 FMV
(4) GEM BVP CO-INV-A LP

 B 7,100,000 FMV
(5) HH HOLDCO CO-INVESTMENT FUND LP

 B 83,665,150 FMV
(6) HH SG SECONDARY FUND LP

 B 12,828,000 FMV
(7) SPRUGOS MAURITIUS I LTD

 B 46,025,593 FMV
(8) CHALKSTREAM KOREA FUND INTERNATIONAL LP

 B 25,000,000 FMV
(9) LSV ADVANTAGE INTERNATIONAL III LTD

 B 389,848 FMV
(10) LSV ADVANTAGE INTERNATIONAL III-B LTD

 B 3,043,059 FMV
(11) CERBERUS HH PARTNERS LP

 S 3,864,734 FMV
(12) GEM NPL CO-INV FUND LP

 S 4,351,644 FMV
(13) HHLF LP

 S 43,054,472 FMV
(14) SOLUS OPPORTUNITIES FUND 2 LP

 S 19,396,949 FMV
(15) CVI HH INVESTMENTS LP

 S 36,000,000 FMV
(16) HH HOLDCO CO-INVESTMENT FUND LP

 S 17,546,687 FMV
(17) HH SG SECONDARY FUND LP

 S 3,498,963 FMV
(18) SPRUGOS MAURITIUS I LTD

 S 90,596,188 FMV
(19) HH ELLINGTON FUND LTD

 S 172,500,000 FMV
(20) COASTLAND RELATIVE VALUE FUND LTD

 S 151,873,341 FMV
(21) TOURMALET MATAWIN OFFSHORE FUND VI-A LP

 B 4,000,000 FMV
(22) TOURMALET MATAWIN OFFSHORE FUND VI-A LP

 S 21,000,000 FMV
(23) MARSHALL WACE MANAGED ACCOUNTS PLC-MW EUROPA FUND II

 S 15,000,000 FMV
(24) IRONSIDES PARTNERS SPECIAL SITUATIONS OFFSHORE FUND LTD

 S 5,000,000 FMV
Schedule R (Form 990) 2015
Schedule R (Form 990) 2015
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income (related, unrelated, excluded from tax under sections 512-514)

(e)
Are all partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V-UBI
amount in box 20
of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2015
Schedule R (Form 990) 2015
Page 5
Part VII
Supplemental Information
Provide additional information for responses to questions on Schedule R (see instructions).
Return Reference Explanation
Schedule R (Form 990) 2015

Additional Data


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