Attach to Form 990 or Form 990-EZ.
Go to
www.irs.gov/Form990 for instructions and the latest information.
| (i) Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 10 above (see instructions)) | (iv) Is the organization listed in your governing document? | (v) Amount of monetary support (see instructions) | (vi) Amount of other support (see instructions) | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
|
Total |
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Calendar year (or fiscal year beginning in) ![]() |
(a) 2015 | (b) 2016 | (c) 2017 | (d) 2018 | (e) 2019 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") .. | 59,709,893 | 71,346,495 | 60,243,416 | 59,023,034 | 62,867,601 | 313,190,439 |
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.... | ||||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 4 | Total. Add lines 1 through 3 | 59,709,893 | 71,346,495 | 60,243,416 | 59,023,034 | 62,867,601 | 313,190,439 |
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. | 30,081,850 | |||||
| 6 | Public support. Subtract line 5 from line 4. | 283,108,589 | |||||
Calendar year
(or fiscal year beginning in) ![]() |
(a) 2015 | (b) 2016 | (c) 2017 | (d) 2018 | (e) 2019 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | 59,709,893 | 71,346,495 | 60,243,416 | 59,023,034 | 62,867,601 | 313,190,439 |
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | 430,555 | 933,027 | 994,910 | 729,749 | 945,520 | 4,033,761 |
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. | 7,021,290 | 8,553,010 | 6,781,431 | 8,229,643 | 9,656,398 | 40,241,772 |
| 11 | Total support. Add lines 7 through 10 | 357,465,972 | |||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2015 | (b) 2016 | (c) 2017 | (d) 2018 | (e) 2019 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513 ..... | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge | ||||||
| 6 | Total. Add lines 1 through 5 | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support. (Subtract line 7c from line 6.) | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2015 | (b) 2016 | (c) 2017 | (d) 2018 | (e) 2019 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||
| Section A - Adjusted Net Income | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Net short-term capital gain | 1 | ||||
| 2 | Recoveries of prior-year distributions | 2 | ||||
| 3 | Other gross income (see instructions) | 3 | ||||
| 4 | Add lines 1 through 3 | 4 | ||||
| 5 | Depreciation and depletion | 5 | ||||
| 6 | Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) | 6 | ||||
| 7 | Other expenses (see instructions) | 7 | ||||
| 8 | Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) | 8 | ||||
| Section B - Minimum Asset Amount | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): | 1 | ||||
| a | Average monthly value of securities | 1a | ||||
| b | Average monthly cash balances | 1b | ||||
| c | Fair market value of other non-exempt-use assets | 1c | ||||
| d | Total (add lines 1a, 1b, and 1c) | 1d | ||||
| e |
Discount claimed for blockage or other factors (explain in detail in Part VI): |
|||||
| 2 | Acquisition indebtedness applicable to non-exempt use assets | 2 | ||||
| 3 | Subtract line 2 from line 1d | 3 | ||||
| 4 | Cash deemed held for exempt use. Enter 1-1/2% of line 3 (for greater amount, see instructions). | 4 | ||||
| 5 | Net value of non-exempt-use assets (subtract line 4 from line 3) | 5 | ||||
| 6 | Multiply line 5 by .035 | 6 | ||||
| 7 | Recoveries of prior-year distributions | 7 | ||||
| 8 | Minimum Asset Amount (add line 7 to line 6) | 8 | ||||
| Section C - Distributable Amount | Current Year | |||||
| 1 | Adjusted net income for prior year (from Section A, line 8, Column A) | 1 | ||||
| 2 | Enter 85% of line 1 | 2 | ||||
| 3 | Minimum asset amount for prior year (from Section B, line 8, Column A) | 3 | ||||
| 4 | Enter greater of line 2 or line 3 | 4 | ||||
| 5 | Income tax imposed in prior year | 5 | ||||
| 6 | Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) | 6 | ||||
| Section D - Distributions | Current Year | |
|---|---|---|
| 1 Amounts paid to supported organizations to accomplish exempt purposes | ||
|
2
Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity |
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| 3 Administrative expenses paid to accomplish exempt purposes of supported organizations | ||
| 4 Amounts paid to acquire exempt-use assets | ||
| 5 Qualified set-aside amounts (prior IRS approval required) | ||
| 6 Other distributions (describe in Part VI). See instructions | ||
| 7Total annual distributions. Add lines 1 through 6. | ||
|
8
Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions |
||
| 9 Distributable amount for 2019 from Section C, line 6 | ||
| 10 Line 8 amount divided by Line 9 amount | ||
| Section E - Distribution Allocations (see instructions) |
(i) Excess Distributions |
(ii) Underdistributions Pre-2019 |
(iii) Distributable Amount for 2019 |
|
|---|---|---|---|---|
| 1 Distributable amount for 2019 from Section C, line 6 | ||||
|
2
Underdistributions, if any, for years prior to 2019 (reasonable cause required-- explain in Part VI). See instructions. |
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| 3 Excess distributions carryover, if any, to 2019: | ||||
| a From 2014....... | ||||
| b From 2015....... | ||||
| c From 2016....... | ||||
| d From 2017....... | ||||
| e From 2018....... | ||||
| fTotal of lines 3a through e | ||||
| g Applied to underdistributions of prior years | ||||
| h Applied to 2019 distributable amount | ||||
|
i
Carryover from 2014 not applied (see instructions) |
||||
| j Remainder. Subtract lines 3g, 3h, and 3i from 3f. | ||||
| 4Distributions for 2019 from Section D, line 7: | ||||
| $ | ||||
| a Applied to underdistributions of prior years | ||||
| b Applied to 2019 distributable amount | ||||
| c Remainder. Subtract lines 4a and 4b from 4. | ||||
|
5
Remaining underdistributions for years prior to 2019, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions. |
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|
6
Remaining underdistributions for 2019. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions. |
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|
7 Excess distributions carryover to 2020. Add lines 3j and 4c. |
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| 8 Breakdown of line 7: | ||||
| a Excess from 2015..... | ||||
| b Excess from 2016..... | ||||
| c Excess from 2017..... | ||||
| d Excess from 2018..... | ||||
| e Excess from 2019..... | ||||
| Facts And Circumstances Test |
|---|
| Part II Section B Line 10 2019 Other Income of 9,656,398 is comprised of 4,280,875 of Clinical Research Program revenue, 4,453,944 of Collaborative Research Agreement projects, 886,743 of External Core Income, and 34,836 of miscellaneous income. |
| Return Reference | Explanation |
|---|
| Software ID: | 19009610 |
| Software Version: | 19.2.1.0 |
Attach to Form 990 or 990-EZ.
Go to www.irs.gov/Form990 for the latest information.
| Return Reference | Explanation |
|---|---|
| Form 990, Part III, Line 1 | Benaroya Research Institute at Virginia Mason BRI is one of the few research institutes in the world devoted to finding causes and cures for autoimmune disease and other diseases of the immune system including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, lupus, inflammatory bowel disease, allergy and cancer. We believe a breakthrough against one of these diseases can lead to progress against them all. BRI is affiliated with the Virginia Mason Health System, which provides governance oversight, development support through the Virginia Mason Foundation as well as being a partner in clinical and translational research. In 2019, BRI launched an ambitious strategic plan with a bold mission to predict, prevent, reverse and cure diseases of the immune system to achieve our vision of a healthy immune system for everyone. Discoveries at BRI are accelerated by our talented researchers, collaborative culture and application of new technologies and data analytics. However, in order to fully realize our mission, we need to better understand what causes the immune system to fall out of balance and what we can do to restore it to health. To that end, BRI has now organized its scientific activities into four new Centers of Discovery 1 Fundamental Immunology, directed by Daniel Campbell, PhD 2 Translational Immunology, directed by Karen Cerosaletti, PhD 3 Interventional Immunology, directed by Carla Greenbaum, MD and 4 Systems Immunology, directed by Peter Linsley, PhD. The Centers work together by building on the discoveries of each, with scientists applying tools and insights across the spectrum of immune system diseases to accelerate research advances. BRI is led by President Jane H. Buckner, MD, and Executive Director/COO Margaret McCormick, PhD. In 2019, through a new funding opportunity BRI initiated a novel Gut Immunology program, which works across the Centers to unite scientists who study different aspects of the same diseases. Many of BRIs research faculty serve concurrently as affiliate professors at the University of Washington and mentor postdoctoral fellows, graduate students and summer interns. |
| Form 990, Part III, Line 4 | One unique quality of BRI is the close integration of four types of medical research - laboratory research, translational research, clinical research and systems biology - to improve lives. Our scientists collaborate to explore basic science as well as clinical applications, which is the best way to design studies with the highest potential for success. At BRI, discovery starts in the laboratory but is driven by patient issues addressed in the clinic. Selected 2019 advancements of the Immune Tolerance Network and in BRIs Centers of Discovery are highlighted as follows. |
| Form 990, Part III, Line 4a | Funding for the Immune Tolerance Network ITN was awarded to BRIs Dr. Jerry Nepom in 2014 from the National Institute of Allergy and Infectious Disease NIAID of the National Institutes of Health NIH. The 7-year award, totaling 27 million annually supports the ITN, a research consortium established in 1999 with a primary focus on the development of new tolerogenic approaches for the treatment and prevention of disease in these clinical areas Type 1 Diabetes, Transplant, Autoimmune disease and Allergy and Asthma. As the Prime recipient of this grant, BRI is responsible for the management of the overall grant from NIAID including oversight of all aspects of the Networks infrastructure. The major activities in 2019 were diverse, but continued to center on preserving the ITNs cohesive project focused environment and its framework which has proven so successful in the management of a large cooperative agreement grant. Key outcomes in 2019 include the following 1 Cross Network Integration A top priority in this reporting period was to continue the successful ITN infrastructure which is spread across three main operational sites. This required careful planning and collaboration as the ITNs major centers of operations are geographically diverse, located in Seattle, San Francisco and Bethesda. Few changes were made to the existing network integration as the current model continues to successfully support the overall ITN program. Establishing new relationships and vital connections within the research community continued to be an ITN goal. 2 Operations and Clinical Trial Support The ITN program team at BRI issued 194 sub-awards in 2019 in support of 27 active ITN clinical trials and numerous supporting ITN mechanistic trials. 3 Supplemental Funding / Partnerships ITN central administration continued to focus on identifying additional opportunities for supplemental funding and/or funding partnerships. a Supplemental Funding Opportunities The ITN Program Team at BRI submitted two supplemental funding requests in 2019. These requests were awarded, bringing in an additional 3.17M in funding to the ITN BRI. b Partnerships The ITN continued its relationship with two pharmaceutical partners for partial funding on two ongoing ITN studies. NIAID is the clinical sponsor on both of these trials. 4 Publication Activity In 2019, 26 ITN publications were published in prestigious research journals and were presented at domestic and international research conferences. These publications represented ITN research in all therapeutic focus areas of the ITN Type 1 Diabetes, Transplant, Autoimmune disease and Allergy and Asthma. 5 Grant Renewal Application With the current ITN grant funding ending in February 2021, the preparation of the grant renewal application was a major focus in Q4, 2019. The renewal was successfully submitted, with expected award notification in late 2020. |
| Form 990, Part III, Line 4b | Center of Fundamental Immunology advances include 1 Linking a New Type of Cell with a Deadly Inflammatory Disorder - A research team made a discovery that lights the way to treat life-threatening complications of autoimmune and viral diseases. The discovery, published in the journal Science, could lead to new treatments for a deadly form of inflammation in children with systemic juvenile idiopathic arthritis SJIA, malaria and Kawasaki disease as well as patients with lupus. The research team found a unique type of cell, which they termed inflammatory hemophagocytes iHPCs, that eat red blood cells in MAS and malaria. They demonstrated that iHPCs develop under the influence of two specific proteins that recognize infection and are associated with autoimmune disease. Next steps will involve collaborations with pediatricians and pediatric rheumatologists to look for iHPCs in the blood of children with autoimmune disease related anemia, as well as healthy individuals, with a goal of quickly identifying potential targets for treatments. Comparisons with blood samples infected by malaria are already under way. 2 A Skin Immune Cell Discovery Challenges Assumptions about T cells - BRI scientists scrutinized a newly identified population of human immune cells in the blood that appear to have everything in common with infection-fighting T cells isolated from the skin. Scientists demonstrated that T cells that were previously assumed to stay in the skin, and are referred to as tissue-resident memory T cells, can exit skin tissue, enter the blood and circulate throughout the body. These T cells can then relocate into skin at other locations of the body. In addition to potential implications for treatment of wounds and skin infections, the identification of this cell population presents an opportunity to identify therapies for immune-related diseases that affect the skin, including scleroderma, psoriasis and a form of lymphoma called mycosis fungoides. |
| Form 990, Part III, Line 4c | Center for Translational Immunology is a research approach that allows scientific observations made in the basic research lab to be quickly evaluated in patient samples, refining our understanding of human disease in an expedient and systematic way. This research is translating new diagnostic and treatment approaches that may improve our ability to predict disease risk, prevent onset of disease, decrease disease progression and make treatments safer and better. The research emphasis of the BRI Translational Research Program crosses a spectrum of diseases caused by or aggravated by the immune system, including cancer and infectious disease. The BRI biorepositories, or biobank, is a collection of blood, serum and tissue samples, as well as medical histories, from healthy volunteers and individuals with diseases involving the immune system. Sample collections began in 2000. BRI scientists and physician collaborators work together to study the blood and serum samples along with medical and demographic data collected from people with autoimmune and immune-mediated diseases. These include multiple sclerosis, type 1 diabetes, lupus, rheumatoid arthritis, inflammatory bowel disease, allergy, asthma and cancer. Advancements in 2019 included the following 1 Personalized Treatments for Peanut Allergy - BRI furthered a two-pronged study to accelerate discovery of treatments for peanut allergy through a collaboration involving three BRI labs, Virginia Mason physicians and sponsors of two clinical trials. The study first investigated peanut allergy patients immune responses and classified them into subgroups. In the second part of the study, researchers are evaluating treatment options used in a pair of clinical trials to determine how specific treatments can be matched to specific patients to teach their immune systems to tolerate peanut protein. 2 Sound Life Project - BRI launched the Sound Life Project, a two-year study in which researchers will track healthy immune systems over time. Seattle-area adults in two age cohorts - 25-35 and 55-65 - began to participate in this groundbreaking study to build a baseline of knowledge about the human immune system and the influence of environmental/lifestyle factors. BRI will use this information about healthy immune systems to serve as a foundation for existing and future disease research programs. The project is in the initial phase of a research partnership led by the Allen Institute for Immunology. 3 Autoimmune Disease Research in the Down Syndrome Population - With the help of a Virginia Mason pediatrician, BRI leveraged a grant from the National Institutes of Health to build a Down syndrome DS biorepository to research the connection between DS and autoimmune disease. The collection includes blood, serum and tissue samples, as well as medical histories, from volunteers, people with DS and their relatives, with and without autoimmune diseases. The DS population has long been underrepresented in medical research, and nearly 50 percent of this population is living with at least one autoimmune disease. BRI is among the first to be awarded a grant dedicated to autoimmune disease in the DS population. 4Identifying biomarkers that predict the success of checkpoint inhibitor immunotherapy drugs used to treat certain types of cancer - Despite the success of checkpoint inhibitors at improving cancer survival rates, they do not work in all patients and often have serious side effects including sudden-autoimmune-like symptoms called immune related adverse events irAEs. BRI scientists took a much closer look at how immune response cells -- known as T cells -- are affected by checkpoint inhibitor drugs. Ultimately, the scientists hope to identify T cell biomarkers that predict which patients are at the lowest or highest risk for autoimmune effects after receiving checkpoint inhibitors. They also explored ways to improve the ability of checkpoint inhibitors to kill cancer cells while protecting healthy tissue. The BRI Clinical Research Program works closely with oncologists at Virginia Mason to enroll subjects in this study. In a second project involving immunotherapy, BRI scientists collaborated to understand, predict and prevent insulin-dependent diabetes following checkpoint therapy for cancer. After treatment with checkpoint inhibitors, roughly 1 of cancer patients develop a kind of insulin-dependent diabetes that appears similar to type 1 diabetes. The goal of this collaborative research initiative was to better understand this phenomenon and to identify the causes of diabetes in these patients. The autoimmunity research collaborators also intended to shed light on the causes of T1D in the broader population. |
| Form 990, Part III, Line 4c continued | 5 Pursuing a Revolution in IBD Treatment - BRI researchers searched for biomarkers that could help make IBD treatment more precise and effective through a precision medicine approach that could tailor treatment to individual patients. They worked to identify biomarkers - proteins and other molecules in patients blood or cells - to predict response to a specific drug. The researchers started this study by taking blood samples from Virginia Mason IBD patients before they started using the drug vedolizumab, and then again after they had taken several doses, carefully analyzing the immune cells in these samples. Vedolizumab binds to a specific type of receptor on the outside of some immune cells, and the researchers discovered that some people who have more of this receptor respond better to the drug. 6 Aiming for Better Lupus Treatments - Immune cells protect us by hunting down bacteria and viruses, but a BRI team found that cells that lack a gene called ATG5 never stop attacking. Eventually, they aim at healthy cells and cause lupus. Scientists think it might be possible to stop these attacks by using medications to reactivate ATG5 and other genes, which could switch off overactive immune cells. A second research team identified a different gene involved in lupus BANK1. This gene plays a role in immune cells called B cells. Many B cells make tiny proteins called antibodies, and some of those antibodies attack healthy cells, causing lupus. The team showed that BANK1 may increase the number of B cells that make antibodies, especially in people with lupus who have a particular BANK1 variant. The work is helping us move toward better, more personalized treatments of lupus. |
| Form 990, Part III, Line 4c continued | The Center for Interventional Immunology translates discoveries in the lab to patient therapies in the clinic through small and large-scale clinical studies. The Center for Interventional Immunology is also home to the Diabetes Clinical Research Program as well as the Clinical Research Program CRP, which provides compliance oversight of all interventional studies at BRI and Virginia Mason Medical Center. The CRP also manages all clinical research conducted by Virginia Mason Medical Center physicians and supports a number of specimen collection protocols developed within the Translational Immunology Center, particularly in cancer research. Details about CRP activities are provided below. Advancements in 2019 included the following 1 BRI leads the Type 1 Diabetes TrialNet, a National Institutes of Health-funded clinical trial network for type 1 diabetes prevention and early treatment, serving as the TrialNet hub of 28 clinical centers working with more than 200 screening and clinical research sites across the U.S. and six other countries. 2 An Immunotherapy Drug that can Delay T1D - A TrialNet prevention study involving diabetes researchers and volunteers at BRI showed a drug that targets the immune system - teplizumab - can delay type 1 diabetes a median of two years in children and adults at high risk. That is good news for relatives of people with type 1 diabetes, who are at 15 times greater risk of the disease than the general population. Samples collected during the trial are being studied to help researchers understand why certain people responded to the drug better than others, and next, researchers hope to conduct additional studies to look for ways to extend the benefits of the drug. 3 The TrialNet Pathway to Prevention study screened relatives of people with type 1 diabetes to find out if these family members are at risk for developing diabetes. Relatives of people with type 1 diabetes have about a three to four percent chance of testing positive for autoantibodies associated with diabetes. At-risk relatives are offered additional tests to estimate their chances of developing type 1 diabetes. Those who qualify have the opportunity to enroll in a prevention trial. All research volunteers are closely monitored for early detection of type 1 diabetes. Early detection of type 1 diabetes may improve blood sugar control and reduce the chances of complications. 4 Home to the JDRF Core for Clinical Assay Validation CAV, BRI plays an important role in identifying type 1 diabetes biomarkers and in helping outside researchers get the most accurate test results. The CAV is pinpointing key biomarkers, such as those indicating which patients will keep making insulin for years and which patients wont. The CAV also helps maintain quality control for a worldwide network of research labs by asking them to perform specific tests and reviewing their results. 5 The Center for systems Immunology analyzes large and complex data sets across all the other Centers, to identify patterns that accelerate discovery and disease breakthroughs. Advancements in 2019 included the following Identifying and helping T1D fast progressors - When some people are diagnosed with type 1 diabetes T1D, the disease progresses so quickly that their pancreas stops making insulin within a year. For others, the process is slower and their disease is easier to manage. BRI researchers revealed that it is possible to identify the fast progressors early and match them with treatments that help keep them healthy for longer. This research showed that slow progressors have higher levels of exhausted CD8 T cells - cells that are worn out from attacking the pancreas. The discovery could lead to a test that identifies how quickly individual patients will lose their ability to make insulin. |
| Form 990, Part III, Line 4d | Clinical Research Program Benaroya Research Institute oversees all clinical research at Virginia Mason Medical Center, which combines the expertise of BRI in management of interventional studies with the remarkable care of a quality healthcare leader. The BRI Clinical Research Program supports BRI and Virginia Mason clinical investigators in studies across a wide variety of autoimmune and immune-mediated diseases and conditions, as well as a broad range of other diseases such as cancer and cardiac disease. Each year the Clinical Research Program staff enrolls approximately 1500 study participants into Virginia Mason trials. This program involves approximately 150 research investigators at Virginia Mason Medical Center, and oversees more than 400 active studies with more than 275 studies currently open to enrollment. Teaming Up Against Celiac Disease - Researchers used tetramer technology pioneered by a BRI scientist and used to isolate particular immune cells to pinpoint attacker T cells in blood samples from patients with celiac disease. In these patients, only about three in 100,000 T cells react to gluten, sparking immune attacks that lead to the diseases debilitating symptoms. The researchers are working to figure out why these cells attack the body, perhaps leading them to diagnostic tools and therapies for patients with celiac symptoms - as well as their family members, because autoimmune disease can run in families. Testing a New MS Therapy - a research study at BRI and Virginia Mason seeks to find out if an experimental oral drug, similar to a currently available MS medication, would be just as effective as the current one, but with fewer gastrointestinal side effects. In an earlier study, half the research participants took this experimental drug and half took the current drug. Participants who finished the five-week study then enrolled in a two-year study of the experimental drug, under way in 2019. |
| Form 990, Part VI, Section A, Line 1a | The governing body delegates to an Executive Committee comprised of four officers of the Board and the Chairs of each standing Board Committee, the authority of the Board of Directors in the management of the corporation as may be deemed by the Executive Committee to be appropriate, to be exercised in time periods between regularly scheduled meetings of the Board of Directors provided that the Executive Committee has the authority to act only in time sensitive or emergency situations. The President and the Executive Director of the corporation serve as ex officio members of the Executive Committee without voting rights. The Executive Committee does not have the authority to amend, alter or repeal the bylaws elect, appoint or remove any member of such Executive Committee or any director or officer of the corporation amend the articles of incorporation adopt a plan of merger or adopt a plan of consolidation with another corporation authorize the sale, lease or exchange of all or substantially all of the property and assets of the corporation not in the ordinary course of business authorize the voluntary dissolution of the corporation or revoke proceedings therefore adopt a plan for the distribution of the assets of the corporation or amend, alter or repeal any resolution of the Board which by its terms provides that it shall not be amended, altered or repealed by such Executive Committee. The Executive Committee also serves as the planning committee for the Board of Directors and oversees any compliance issues raised by the Board of Directors. |
| Form 990, Part VI, Section A, Line 6,7 | Virginia Mason Health System VMHS is the sole corporate member of Benaroya Research Institute at Virginia Mason BRI. VMHS as the sole voting member has the following approval rights a election or appointment of Directors and Officers of the Board of Directors b removal of Directors and Officers of the Board of Directors including any executive officer of the corporation c approval of all long-range and short-range plans proposed by the Board of Directors d approval of the annual capital and operating budgets proposed by the Board of Directors e approval of the borrowing of funds where the amount borrowed is in excess of Five Hundred Thousand Dollars 500,000 f approval of the sale, lease, exchange, mortgage, pledge or disposal of all or substantially all of the property and assets g approval of all amendments to or repeal of the Agreement Association or the Bylaws of the corporation h all other rights and powers as specified in the Washington Nonprofit Corporation Act. |
| Form 990, Part VI, Section B, Line 11b | The VMHS Audit and Compliance Committee ACC, a committee composed of independent community members has been delegated responsibility for oversight of the annual Form 990 preparation process including a selection, engagement, and review of the performance of the independent tax preparer b review of the annual draft Form 990 tax return, and c recommendation of the final Form 990 tax return for review to the BRI Board of Directors. Annually, at the September meeting, management and the tax preparer provide the ACC with an initial draft of the Form 990 and present an overview of the Form 990 preparation process. The final Form 990 is reviewed by the ACC in November followed by a Board review of the final Form 990 prior to filing. The final Form 990 tax return is provided to each member of the Board of Directors via electronic delivery. |
| Form 990, Part VI, Section B, Line 12c | The VMHS Governance Committee has been delegated accountability for oversight of the process for disclosure, evaluation and management of conflict of interest involving any member of the BRI Board of Directors, executive leadership or key employees Covered Person. Pursuant to the Conflict of Interest Policy, an annual conflict of interest questionnaire is distributed to all Covered Persons. In addition, a Covered Person has an on-going duty to disclose the existence of a conflict of interest at any time an actual or potential conflict arises. Each Covered Person is required upon appointment and annually thereafter to attest to a statement that affirms that such person has a received a copy of the Conflict of Interest Policy b has read and understands the Policy c has agreed to comply with the Policy and d understands that BRI is a charitable organization and that in order to maintain its federal tax exemption must engage in activities that accomplish its tax-exempt purposes. Written disclosures are reviewed by the Governance Committee to determine if an actual or potential conflict of interest exists and if so, how it should be managed. The Covered Person is informed in writing regarding the determination the Conflict of Interest Management Plan. No Covered Person with an actual or potential conflict of interest shall engage in an activity on BRIs behalf related to the disclosed actual or potential Conflict of Interest unless such activity is permitted by the Conflict of Interest Management Plan or until the Covered Person has undertaken all steps set forth in the Management Plan to manage, reduce or eliminate the conflict. All Covered Persons have a duty to disclose the existence of any actual or potential conflict of interest with respect to meeting agenda items. The Conflict of Interest Policy requires that copies of the Conflict of Interest Questionnaire be completed annually by each covered Person and any Conflict of Interest Management Plan be maintained. |
| Form 990, Part VI, Section B, Line 15 | The VMHS Compensation and Benefits Board Committee, a committee composed solely of independent directors none of whom have a conflict of interest, is accountable for setting reasonable total compensation packages for each executive, officer and key employee Executive consistent with BRIs compensation philosophy and principles. The Committee approves annual goals and performance criteria which are used in determining merit increases and variable compensation opportunities. The Committee assesses performance against these goals. The Committee selects and engages a qualified independent compensation consultant to review and analyze the total compensation and benefits packages of the Executives. The Committee as part of its analysis obtains from the compensation consultant appropriate comparability data including total compensation paid by similarly situated organizations for positions that are functionally comparable to each of the Executives. The Committee will consider the significant terms of the agreement with each Executive including the total compensation to be paid and the employees duties and responsibilities. Consistent with the compensation philosophy and principles, the Committee approves total compensation packages for each of the Executives based on information presented to the Committee, reasonableness and the best interest of BRI. The Committees decisions regarding compensation for each Executive are documented in written resolutions and minutes of the Committee. The Committee promptly reports its actions to the VMHS board which reports are reflected in the Boards minutes. The individual positions who were reviewed in 2019 were Jane Buckner, BRI President and Director, Carla Greenbaum, BRI Director, Margaret McCormick, Executive Director and Chief Operating Officer, and Michael Labosier, Chief Financial Officer. |
| Form 990, Part VI, Section C, Line 19 | The organizations Articles, Bylaws, Conflict of Interest Policy and financial statements are made available upon request. |
| Software ID: | 19009610 |
| Software Version: | 19.2.1.0 |
|
Affiliated Group Business Name:
Benaroya Research Institute at Virginia Mason
Address. Either US or Foreign Type:
1200 Ninth Avenue
Seattle, WA98101 EIN:
91-0653422
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
71,446,676
Total Exempt Purpose Expenditures:
71,446,676
Lobbying Nontaxable Amount:
40,449
Grassroots Nontaxable Amount:
10,112
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|
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Affiliated Group Business Name:
Virginia Mason Medical Center
Address. Either US or Foreign Type:
1100 Ninth Avenue
Seattle, WA98101 EIN:
91-0565539
Electing Organization Checkbox:
Total Grassroots Lobbying:
134,909
Total Direct Lobbying:
63,581
Total Lobbying Expenditures:
198,490
Other Exempt Purpose Expenditures:
1,174,521,397
Total Exempt Purpose Expenditures:
1,174,719,887
Lobbying Nontaxable Amount:
665,053
Grassroots Nontaxable Amount:
166,263
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|
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Affiliated Group Business Name:
Virginia Mason Institute
Address. Either US or Foreign Type:
1100 Ninth Avenue
Seattle, WA98101 EIN:
26-3763656
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
6,260,831
Total Exempt Purpose Expenditures:
6,260,831
Lobbying Nontaxable Amount:
3,544
Grassroots Nontaxable Amount:
886
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|
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Affiliated Group Business Name:
Virginia Mason Health System
Address. Either US or Foreign Type:
1100 Ninth Avenue
Seattle, WA98101 EIN:
91-1351110
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
14,136,817
Total Exempt Purpose Expenditures:
14,136,817
Lobbying Nontaxable Amount:
8,003
Grassroots Nontaxable Amount:
2,001
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|
|
Affiliated Group Business Name:
Yakima Valley Memorial Hospital Association
Address. Either US or Foreign Type:
2811 Tieton Drive
Yakima, WA98902 EIN:
91-0567263
Electing Organization Checkbox:
Total Grassroots Lobbying:
48,610
Total Direct Lobbying:
60,000
Total Lobbying Expenditures:
108,610
Other Exempt Purpose Expenditures:
499,682,326
Total Exempt Purpose Expenditures:
499,790,936
Lobbying Nontaxable Amount:
282,950
Grassroots Nontaxable Amount:
70,738
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
|