Form990
Click to see attachment
Department of the TreasuryInternal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)
MediumBullet Do not enter social security numbers on this form as it may be made public.
MediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public Inspection
A For the 2019 calendar year, or tax year beginning 12-01-2019 , and ending 11-30-2020
BCheck if applicable:
CName of organization
VAN ANDEL RESEARCH INSTITUTE
 
 
Doing business as
 
 
Number and street (or P.O. box if mail is not delivered to street address)
333 BOSTWICK AVENUE NE
 
Room/suite
City or town, state or province, country, and ZIP or foreign postal code
GRAND RAPIDS, MI49503
D Employer identification number

52-2000823
E Telephone number

G Gross receipts $ 89,082,168
F Name and address of principal officer:
TIMOTHY J MYERS
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI49503
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.VAI.ORG
H(a)
Is this a group return for
subordinates?
H(b)
Are all subordinates
included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:  
L Year of formation: 1996
M State of legal domicile: MI
Part I
Summary
Activities  & Governance 1 Briefly describe the organization’s mission or most significant activities: MEDICAL RESEARCH ORGANIZATION
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 6
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 5
5 Total number of individuals employed in calendar year 2019 (Part V, line 2a) ...... 5 525
6 Total number of volunteers (estimate if necessary) ............. 6 12
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 228,355
b Net unrelated business taxable income from Form 990-T, line 39 ......... 7b 0
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 74,898,909 79,336,784
9 Program service revenue (Part VIII, line 2g) ......... 1,879,646 845,797
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 1,317,104 445,632
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 8,264,369 8,263,465
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12) 86,360,028 88,891,678
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 2,433,098 2,413,493
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 45,621,394 47,981,506
16a Professional fundraising fees (Part IX, column (A), line 11e) ..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet782,420    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 51,587,236 44,034,771
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 99,641,728 94,429,770
19 Revenue less expenses. Subtract line 18 from line 12....... -13,281,700 -5,538,092
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 274,298,502 289,629,145
21 Total liabilities (Part X, line 26)............. 405,586,337 453,494,619
22 Net assets or fund balances. Subtract line 21 from line 20..... -131,287,835 -163,865,474
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
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Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
Preparer's signature
Date
PTIN
Firm's name MediumBullet

Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ..........
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y Form 990 (2019)
Form 990 (2019)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III..............
1
Briefly describe the organization’s mission: MEDICAL RESEARCH ORGANIZATION VAN ANDEL RESEARCH INSTITUTE IS AN INDEPENDENT BIOMEDICAL RESEARCH ORGANIZATION COMMITTED TO IMPROVING THE HEALTH AND ENHANCING THE LIVES OF CURRENT AND FUTURE GENERATIONS.
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? .....................
If "Yes," describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ...........................
If "Yes," describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 12,400,365 including grants of $ 333,513 ) (Revenue $ 354,554 )
CENTER FOR CANCER AND CELL BIOLOGY SCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS.
4b (Code:   ) (Expenses $ 13,204,828 including grants of $ 2,003,389 ) (Revenue $ 84,102 )
CENTER FOR EPIGENETICSSCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS.
4c (Code:   ) (Expenses $ 8,118,583 including grants of $ 53,646 ) (Revenue $ 13,194 )
CENTER FOR NEURODEGENERATIVE SCIENCESEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM'S ACCOMPLISHMENTS.
(Code:   ) (Expenses $ 31,117,369 including grants of $ 22,945 ) (Revenue $ 393,947 )
4d Other program services (Describe in Schedule O.)
(Expenses $ 31,117,369 including grants of $ 22,945 ) (Revenue $ 393,947 )
4e Total program service expensesMediumBullet64,841,145
Form 990 (2019)
Form 990 (2019)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule AClick to see attachment.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? Click to see attachment...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part IClick to see attachment.............
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part IIClick to see attachment.........
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If "Yes," complete Schedule C, Part IIIClick to see attachment..
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part IClick to see attachment.........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part IIClick to see attachment....
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes,"
complete Schedule D,
Part IIIClick to see attachment..............
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IVClick to see attachment..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi endowments? If "Yes," complete Schedule D, Part V......
10
Yes
 
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete
Schedule D,
Part VI. Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIClick to see attachment.......
11b
 
No
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIIClick to see attachment.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IXClick to see attachment............
11d
Yes
 
e
Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part XClick to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part XClick to see attachment
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XII
Click to see attachment......................
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States? .....
14a
 
No
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV.........Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV.....Click to see attachment
15
 
No
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV...Click to see attachment
16
 
No
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I(see instructions) ....Click to see attachment
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............ Click to see attachment
18
Yes
 
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................Click to see attachment
19
 
No
20a
Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....
20a
 
No
b
If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
21
Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II.....Click to see attachment
21
Yes
 
Form 990 (2019)
Form 990 (2019)
Page 4
Part IV
Checklist of Required Schedules (continued)
Yes
No
22
Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........Click to see attachment
22
Yes
 
23
Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a...............Click to see attachment
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............
24c
 
No
d
Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...
24d
 
No
25a
Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I ....
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I.......................
25b
 
No
26
Did the organization report any amount on Part X, line 5 or 22 for receivables from or payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II...........
26
 
No
27
Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or employee thereof, a grant selection committee member, or to a 35% controlled entity (including an employee thereof) or family member of any of these persons?
If "Yes," complete
Schedule L, Part III.........................
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If "Yes," complete Schedule L, Part IV......................
28a
 
No
b
A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV.....
28b
 
No
c
A 35% controlled entity of one or more individuals and/or organizations described in lines 28a or 28b? If "Yes," complete Schedule L, Part IV.....................
28c
 
No
29
Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M..
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M .................
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II........................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I............Click to see attachment
33
Yes
 
34
Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1.........................Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ...Click to see attachment
35b
Yes
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2............. Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........
Yes
No
1a
Enter the number reported in Box 3 of Form 1096. Enter -0- if not applicable ..
1a
105
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
 
 
Form 990 (2019)
Form 990 (2019)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance (continued)
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
525
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..
4a
 
No
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...
6a
 
No
b
If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................
7a
 
No
b
If "Yes," did the organization notify the donor of the value of the goods or services provided? .....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................
7c
 
No
d
If "Yes," indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? ........
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the sponsoring organization make any taxable distributions under section 4966?........
9a
 
 
b
Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If "Yes," enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state? .........
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..
14b
 
 
15
Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or excess parachute payment(s) during the year? ....................
If "Yes," see instructions and file Form 4720, Schedule N.
15
 
No
16
Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ..
If "Yes," complete Form 4720, Schedule O.
16
 
No
Form 990 (2019)
Form 990 (2019)
Page 6
Part VI
Governance, Management, and Disclosure For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI..............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year
1a
6
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent
1b
5
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
Yes
 
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? .
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
Yes
 
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .......................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If "No," go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe in Schedule O how this was done...................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the states with which a copy of this Form 990 is required to be filedMediumBullet
MI
18
Section 6104 requires an organization to make its Form 1023 (or 1024-A if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBulletTIMOTHY J MYERS VP & CFO333 BOSTWICK AVENUE NE   GRAND RAPIDS,MI495032518 (616) 234-5368
Form 990 (2019)
Form 990 (2019)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII..............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

See instructions for the order in which to list the persons above.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and title
(B)
Average hours per week (list any hours for related organizations below dotted line)
(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee)
(D)
Reportable compensation from the organization (W-2/1099-MISC)
(E)
Reportable compensation from related organizations (W-2/1099-MISC)
(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(1) DAVID VAN ANDEL......................................................................
CHAIRMAN / CEO
36.00
.................
17.00
X   X       520,256 0 156,846
(2) DR GEORGE VANDE WOUDE......................................................................
TRUSTEE
1.00
.................
0.00
X           9,000 0 0
(3) DR JAMES FAHNER......................................................................
TRUSTEE
1.00
.................
1.00
X           7,000 2,200 0
(4) DR MAX WICHA......................................................................
TRUSTEE
1.00
.................
0.00
X           13,000 0 0
(5) DR MICHELLE LEBEAU......................................................................
TRUSTEE
1.00
.................
0.00
X           8,000 0 0
(6) DR TOM DEMEESTER......................................................................
TRUSTEE
1.00
.................
0.00
X           9,000 0 0
(7) DR JANA HALL......................................................................
CHIEF OPERATIONS OFFICER
52.00
.................
1.00
    X       463,709 0 145,389
(8) TIMOTHY MYERS......................................................................
V.P. & CHIEF FINANCIAL OFFICER
50.00
.................
3.00
    X       344,197 0 99,590
(9) DR PETER JONES......................................................................
CHIEF SCIENTIFIC OFFICER & RES. DIR.
52.00
.................
1.00
      X     752,533 0 235,728
(10) THOMAS CURRAN JR......................................................................
GENERAL COUNSEL
50.00
.................
3.00
      X     276,743 0 80,596
(11) GERALD CALLAHAN......................................................................
CHIEF STRATEGIC OFFICER
51.00
.................
2.00
      X     381,738 0 125,592
(12) KATHY VOGELSANG......................................................................
CHIEF INVESTMENT OFFICER
45.00
.................
0.00
        X   742,294 0 438,840
(13) DR PATRIK BRUNDIN......................................................................
ASSOCIATE RESEARCH DIRECTOR
45.00
.................
0.00
        X   529,770 0 117,375
(14) DR PETER LAIRD......................................................................
DISTINGUISHED INVESTIGATOR
45.00
.................
0.00
        X   431,975 0 74,632
(15) TED HEILMAN......................................................................
ASSOC DIRECT-SR. PORTFOLIO MGR.
45.00
.................
0.00
        X   418,301 0 262,994
(16) DR GERD PFEIFER......................................................................
SR. SCIENTIFIC INVESTIGATOR
45.00
.................
0.00
        X   384,927 0 47,603


Form 990 (2019)
Form 990 (2019)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and title
(B)
Average hours per week (list any hours for related organizations below dotted line)
(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee)
(D)
Reportable compensation from the organization (W-2/1099-MISC)
(E)
Reportable compensation from related organizations (W-2/1099-MISC)
(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;


























1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)...........MediumBullet 5,292,443 2,200 1,785,185
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet96
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............
3
 
No
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual
...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address
(B)
Description of services
(C)
Compensation
HOGAN LOVELLS US LLP

COLUMBIA SQUARE 555 THIRTEENTH ST
WASHINGTON,DC20004
ATTORNEY SERVICES 523,385
DE LAGE LANDEN FIN SVCS INC

1111 OLD EAGLE SCHOOL ROAD
WAYNE,PA19087
FINANCING SERVICES 359,793
ALLIED UNIVERSAL SECURITY SVCS

PO BOX 828854
PHILADELPHIA,PA191828854
SECURITY SERVICES 301,714
SECURALARM SYSTEMS INC

112 54TH STREET SW
GRAND RAPIDS,MI49548
SECURITY SERVICES 190,424
ANDY J EGAN COMPANY INC

2001 WALDORF NW STE 200
GRAND RAPIDS,MI49544
MAINTENANCE SERVICES 189,566
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet17
Form 990 (2019)
Form 990 (2019)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII.............
(A)
Total revenue
(B)
Related or
exempt
function
revenue
(C)
Unrelated
business
revenue
(D)
Revenue
excluded from
tax under sections
512 - 514
Contributions, Gifts, GrantAmt and OtherAmt Similar Amounts 1a Federated campaigns..1a  
b Membership dues..1b  
c Fundraising events..1c 88,428
d Related organizations1d 54,223,134
e Government grants (contributions)1e 18,537,976
f All other contributions, gifts, grants, and similar amounts not included above1f 6,487,246
g Noncash contributions included in lines 1a - 1f:$ 1g 22,142
h Total. Add lines 1a-1f.......MediumBullet 79,336,784
 Program Service RevenueAmt Business Code
2a RESEARCH BILLED REV 541700 845,797 624,920 220,877  
b
c
d
e
f All other program service revenue.        
g Total. Add lines 2a–2f .....MediumBullet 845,797
 OtherAmtRevenueAmt 3 Investment income (including dividends, interest, and othersimilar amounts) ......MediumBullet 414,114     414,114
4 Income from investment of tax-exempt bond proceedsMediumBullet        
5 Royalties...........MediumBullet 26,392     26,392
(ii) Personal (i) Real
6a Gross rents   108,000 6a
b Less: rental expenses   109,961 6b
c Rental income or (loss)   -1,961 6c
d Net rental income or (loss).......MediumBullet -1,961     -1,961
(ii) Other (i) Securities
7a Gross amount from sales of assets other than inventory 38,500   7a
b Less: cost or other basis and sales expenses 6,982   7b
c Gain or (loss) 31,518   7c
d Net gain or (loss).........MediumBullet 31,518     31,518
8a Gross income from fundraising events (not including $ 88,428of contributions reported on line 1c). See Part IV, line 18 ....
8a 7,712
b Less: direct expenses ... 8b 56,986
c Net income or (loss) from fundraising events..MediumBullet -49,274   -49,274
9a Gross income from gaming activities.
See Part IV, line 19 ...
9a 9,259
b Less: direct expenses ... 9b 12,920
c Net income or (loss) from gaming activities..MediumBullet -3,661     -3,661
10a Gross sales of inventory, less
returns and allowances ..
10a 11,896
b Less: cost of goods sold .. 10b 3,641
c Net income or (loss) from sales of inventory..MediumBullet 8,255 777 7,478  
Business Code Miscellaneous Revenue
11a ALLOCATED ADMIN. EXP. 561000 7,725,025     7,725,025
b GAIN ON C3 ACQUISIT. 900099 213,714     213,714
c REIMBURSED EXPENSES 900099 137,588     137,588
d All other revenue .... 207,387     207,387
e Total. Add lines 11a–11d ...... MediumBullet 8,283,714
12 Total revenue. See instructions.....MediumBullet 88,891,678 625,697 228,355 8,700,842
Form 990 (2019)
Form 990 (2019)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX..............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII.
(A)
Total expenses
(B)
Program service expenses
(C)
Management and general expenses
(D)
Fundraising
expenses
1 Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 .... 1,900,745 1,900,745
2 Grants and other assistance to domestic individuals. See Part IV, line 22 ........... 512,748 512,748
3 Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. .............    
4 Benefits paid to or for members .......    
5 Compensation of current officers, directors, trustees, and key employees ........... 3,270,696 873,582 2,397,114  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........        
7 Other salaries and wages........ 35,488,373 23,593,456 11,415,396 479,521
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 2,945,386 1,968,643 939,588 37,155
9 Other employee benefits ....... 3,956,520 2,644,467 1,262,143 49,910
10 Payroll taxes ........... 2,320,531 1,551,001 740,257 29,273
11 Fees for services (non-employees):        
a Management ......        
b Legal ......... 1,556,708 85,382 1,471,326  
c Accounting ........... 128,809   128,809  
d Lobbying ........... 96,000   96,000  
e Professional fundraising services. See Part IV, line 17    
f Investment management fees ......        
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) 4,276,977 2,962,202 1,304,562 10,213
12 Advertising and promotion .... 981,123 4,694 851,686 124,743
13 Office expenses ....... 196,114 33,411 162,590 113
14 Information technology ...... 376,019 153,140 197,754 25,125
15 Royalties .. 371   371  
16 Occupancy ........... 2,537,460 1,977,941 559,361 158
17 Travel ............ 219,340 123,562 80,134 15,644
18 Payments of travel or entertainment expenses for any federal, state, or local public officials .        
19 Conferences, conventions, and meetings .... 80,578 44,778 35,800  
20 Interest ........... 8,726,165 6,699,249 2,026,916  
21 Payments to affiliates .......        
22 Depreciation, depletion, and amortization .. 11,763,681 10,030,415 1,733,266  
23 Insurance ... 630,655 314,944 315,711  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a FED / STATE INCOME TAX 44,223   44,223  
b LAB SUPPLIES & SERVICES 5,029,175 5,029,175    
c EQUIPMENT & SOFTWARE 4,015,146 2,279,055 1,734,692 1,399
d OTHER SCIENTIFIC 982,042 982,042    
e All other expenses 2,394,185 1,076,513 1,308,506 9,166
25 Total functional expenses. Add lines 1 through 24e 94,429,770 64,841,145 28,806,205 782,420
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2019)
Form 990 (2019)
Page 11
Part X
Balance Sheet
Check if Schedule O contains a response or note to any line in this Part IX..............
(A)
Beginning of year
(B)
End of year
Assets 1 Cash–non-interest-bearing ........   1  
2 Savings and temporary cash investments ......... 5,389,037 2 963,154
3 Pledges and grants receivable, net ...... 5,035,192 3 4,442,322
4 Accounts receivable, net ............. 3,713,866 4 3,727,182
5 Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
  5  
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
  6  
7 Notes and loans receivable, net ........... 1,565,997 7 1,493,561
8 Inventories for sale or use ............ 261,785 8 689,899
9 Prepaid expenses and deferred charges ...... 1,722,950 9 1,988,548
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 301,703,323
b Less: accumulated depreciation 10b 131,229,621 178,838,822 10c 170,473,702
11 Investments—publicly traded securities .   11  
12 Investments—other securities. See Part IV, line 11 ..... 6,450,853 12 6,250,777
13 Investments—program-related. See Part IV, line 11 ..   13  
14 Intangible assets ...............   14  
15 Other assets. See Part IV, line 11 ........... 71,320,000 15 99,600,000
16 Total assets. Add lines 1 through 15 (must equal line 33)... 274,298,502 16 289,629,145
Liabilities 17 Accounts payable and accrued expenses ..... 90,870,304 17 113,769,230
18 Grants payable ...   18  
19 Deferred revenue ......... 3,282,648 19 3,488,051
20 Tax-exempt bond liabilities ......... 219,744,537 20 219,755,485
21 Escrow or custodial account liability. Complete Part IV of Schedule D   21  
22 Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
  22  
23 Secured mortgages and notes payable to unrelated third parties ..   23  
24 Unsecured notes and loans payable to unrelated third parties ..   24  
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D 91,688,848 25 116,481,853
26 Total liabilities. Add lines 17 through 25.. 405,586,337 26 453,494,619
Net Assets or Fund Balance Organizations that follow FASB ASC 958, check here MediumBullet and complete lines 27, 28, 32, and 33.
27 Net assets without donor restrictions .......... -137,956,356 27 -169,411,355
28 Net assets with donor restrictions ........... 6,668,521 28 5,545,881
Organizations that do not follow FASB ASC 958, check here MediumBullet and complete lines 29 through 33.
29 Capital stock or trust principal, or current funds .....   29  
30 Paid-in or capital surplus, or land, building or equipment fund ...   30  
31 Retained earnings, endowment, accumulated income, or other funds   31  
32 Total net assets or fund balances ........... -131,287,835 32 -163,865,474
33 Total liabilities and net assets/fund balances ........ 274,298,502 33 289,629,145
Form 990 (2019)
Form 990 (2019)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI..............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
88,891,678
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
94,429,770
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
-5,538,092
4
Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ..
4
-131,287,835
5
Net unrealized gains (losses) on investments ...............
5
51,845
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
-27,091,392
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32, column (B))
10
-163,865,474
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII.............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
Yes
 
b
If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.
3b
Yes
 
Form 990 (2019)
Form 990 (2019)
Additional Data


Software ID:  
Software Version:  
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ.
right arrow Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)
1
2
3
4
5
6
7
8
9
10
11
12
a
b
c
d
e
f
Enter the number of supported organizations ...............................  
g
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 10 above (see instructions)) (iv) Is the organization listed in your governing document? (v) Amount of monetary support (see instructions) (vi) Amount of other support (see instructions)
Yes No
Total
 
   
For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2015 (b) 2016 (c) 2017 (d) 2018 (e) 2019 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") ..            
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3            
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f)..  
6 Public support. Subtract line 5 from line 4.  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2015 (b) 2016 (c) 2017 (d) 2018 (e) 2019 (f) Total
7 Amounts from line 4..            
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...            
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..            
11 Total support. Add lines 7 through 10  
12
12
 
13
First five years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here........................................right arrow
Section C. Computation of Public Support Percentage
14
14
 
15
15
 
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2015 (b) 2016 (c) 2017 (d) 2018 (e) 2019 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose            
3 Gross receipts from activities that are not an unrelated trade or business under section 513 .....            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge            
6 Total. Add lines 1 through 5            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support. (Subtract line 7c from line 6.)  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2015 (b) 2016 (c) 2017 (d) 2018 (e) 2019 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 4
Part IV
Supporting Organizations
(Complete only if you checked a box on line 12 of Part I. If you checked 12a of Part I, complete Sections A and B. If you checked 12b of Part I, complete Sections A and C. If you checked 12c of Part I, complete Sections A, D, and E. If you checked 12d of Part I, complete Sections A and D, and complete Part V.)
Section A. All Supporting Organizations
Yes
No
1
Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.
1
 
 
2
Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).
2
 
 
3a
Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer (b) and (c) below.
3a
 
 
b
Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.
3b
 
 
c
Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.
3c
 
 
4a
Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked 12a or 12b in Part I, answer (b) and (c) below.
4a
 
 
b
Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.
4b
 
 
c
Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.
4c
 
 
5a
Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer (b) and (c) below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).
5a
 
 
b
Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?
5b
 
 
c
Substitutions only. Was the substitution the result of an event beyond the organization's control?
5c
 
 
6
Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.
6
 
 
7
Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ) .
7
 
 
8
Did the organization make a loan to a disqualified person (as defined in section 4958) not described in line 7? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ).
8
 
 
9a
Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.
9a
 
 
b
Did one or more disqualified persons (as defined in line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.
9b
 
 
c
Did a disqualified person (as defined in line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.
9c
 
 
10a
Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.
10a
 
 
b
Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).
10b
 
 
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 5
Part IV
Supporting Organizations (continued)
Yes
No
11
Has the organization accepted a gift or contribution from any of the following persons?
a
A person who directly or indirectly controls, either alone or together with persons described in (b) and (c) below, the governing body of a supported organization?
11a
 
 
b
A family member of a person described in (a) above?
11b
 
 
c
A 35% controlled entity of a person described in (a) or (b) above? If “Yes” to a, b, or c, provide detail in Part VI.
11c
 
 
Section B. Type I Supporting Organizations
Yes
No
1
Did the directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.
1
 
 
2
Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.
2
 
 
Section C. Type II Supporting Organizations
Yes
No
1
Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).
1
 
 
Section D. All Type III Supporting Organizations
Yes
No
1
Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?
1
 
 
2
Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).
2
 
 
3
By reason of the relationship described in (2), did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.
3
 
 
Section E. Type III Functionally-Integrated Supporting Organizations
1
Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):
a
b
c
2
Activities Test. Answer (a) and (b) below.
Yes
No
a
Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.
2a
 
 
b
Did the activities described in (a) constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.
2b
 
 
3
Parent of Supported Organizations. Answer (a) and (b) below.
a
Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations? Provide details in Part VI.
3a
 
 
b
Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.
3b
 
 
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 6
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations
1
Section A - Adjusted Net Income (A) Prior Year (B) Current Year
(optional)
1 Net short-term capital gain 1    
2 Recoveries of prior-year distributions 2    
3 Other gross income (see instructions) 3    
4 Add lines 1 through 3 4    
5 Depreciation and depletion 5    
6 Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) 6    
7 Other expenses (see instructions) 7    
8 Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) 8    
Section B - Minimum Asset Amount (A) Prior Year (B) Current Year
(optional)
1 Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): 1
a Average monthly value of securities 1a    
b Average monthly cash balances 1b    
c Fair market value of other non-exempt-use assets 1c    
d Total (add lines 1a, 1b, and 1c) 1d    
e Discount claimed for blockage or other factors
(explain in detail in Part VI):  
2 Acquisition indebtedness applicable to non-exempt use assets 2    
3 Subtract line 2 from line 1d 3    
4 Cash deemed held for exempt use. Enter 1-1/2% of line 3 (for greater amount, see instructions). 4    
5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5    
6 Multiply line 5 by .035 6    
7 Recoveries of prior-year distributions 7    
8 Minimum Asset Amount (add line 7 to line 6) 8    
Section C - Distributable Amount Current Year
1 Adjusted net income for prior year (from Section A, line 8, Column A) 1  
2 Enter 85% of line 1 2  
3 Minimum asset amount for prior year (from Section B, line 8, Column A) 3  
4 Enter greater of line 2 or line 3 4  
5 Income tax imposed in prior year 5  
6 Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) 6  
7
Schedule A (Form 990 or 990-EZ) 2019

Schedule A (Form 990 or 990-EZ) 2019
Page 7
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)
Section D - Distributions Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes  
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in
excess of income from activity
 
3 Administrative expenses paid to accomplish exempt purposes of supported organizations  
4 Amounts paid to acquire exempt-use assets  
5 Qualified set-aside amounts (prior IRS approval required)  
6 Other distributions (describe in Part VI). See instructions  
7Total annual distributions. Add lines 1 through 6.  
8 Distributions to attentive supported organizations to which the organization is responsive (provide
details in Part VI). See instructions
 
9 Distributable amount for 2019 from Section C, line 6  
10 Line 8 amount divided by Line 9 amount  
Section E - Distribution Allocations (see instructions) (i)
Excess Distributions
(ii)
Underdistributions
Pre-2019
(iii)
Distributable
Amount for 2019
1 Distributable amount for 2019 from Section C, line 6  
2 Underdistributions, if any, for years prior to 2019 (reasonable cause required-- explain in Part VI).
See instructions.
 
3 Excess distributions carryover, if any, to 2019:
a From 2014.......  
b From 2015.......  
c From 2016.......  
d From 2017.......  
e From 2018.......  
fTotal of lines 3a through e  
g Applied to underdistributions of prior years  
h Applied to 2019 distributable amount  
i Carryover from 2014 not applied (see
instructions)
 
j Remainder. Subtract lines 3g, 3h, and 3i from 3f.  
4Distributions for 2019 from Section D, line 7:
$  
a Applied to underdistributions of prior years  
b Applied to 2019 distributable amount  
c Remainder. Subtract lines 4a and 4b from 4.  
5 Remaining underdistributions for years prior to
2019, if any. Subtract lines 3g and 4a from line 2.
If the amount is greater than zero, explain in Part VI.
See instructions.
 
6 Remaining underdistributions for 2019. Subtract
lines 3h and 4b from line 1. If the amount is greater
than zero, explain in Part VI. See instructions.
 
7 Excess distributions carryover to 2020. Add lines
3j and 4c.
 
8 Breakdown of line 7:
a Excess from 2015.....  
b Excess from 2016.....  
c Excess from 2017.....  
d Excess from 2018.....  
e Excess from 2019.....  
Schedule A (Form 990 or 990-EZ) (2019)

Schedule A (Form 990 or 990-EZ) 2019
Page 8
Part VI
Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Return Reference Explanation
Schedule A (Form 990 or 990-EZ) 2019


Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors

Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
Arrow Bullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2019
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ






Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......... Arrow Bullet $  
Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2019)
Schedule B (Form 990, 990-EZ, or 990-PF) (2019) Page 2
Name of organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number
52-2000823
Part I
Contributors
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
RESTRICTED
 
 
 
 
  ,    

$ RESTRICTED


(Complete Part II for noncash contributions.)
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.
(b)
Name, address, and ZIP + 4
(c)
Total contributions
(d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2019)
Schedule B (Form 990, 990-EZ, or 990-PF) (2019)
Page 3
Name of organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
(a)
No. from Part I
(b)
Description of noncash property given
(c)
FMV (or estimate)
(See instructions)
(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2019)
Schedule B (Form 990, 990-EZ, or 990-PF) (2019)
Page 4
Name of organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part III
Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a)
No. from Part I
(b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I
(b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I
(b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I
(b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2019)

Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527

SchCMd Bullet Complete if the organization is described below. SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd BulletGo to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public
Inspection
If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV (see instructions for definition of “political campaign activities")

2
Political campaign activity expenditures (see instructions) ....................................................................SchCMd Bullet
$  
3
Volunteer hours for political campaign activities (see instructions) ..................................................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 ................................SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 .......................SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................
4a
Was a correction made? ......................................................................................................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b...........SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ...................................................................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6
For Paperwork Reduction Act Notice, see the instructions for Form 990 or 990-EZ.
Cat. No. 50084S
Schedule C (Form 990 or 990-EZ) 2019

Schedule C (Form 990 or 990-EZ) 2019
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.)
(a) Filing
organization's
totals
(b) Affiliated group totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......................    
b Total lobbying expenditures to influence a legislative body (direct lobbying) ........................ 96,000  
c Total lobbying expenditures (add lines 1a and 1b) ............................................................ 96,000  
d Other exempt purpose expenditures ............................................................................... 94,333,770  
e Total exempt purpose expenditures (add lines 1c and 1d) .................................................. 94,429,770  
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.
1,000,000  
If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
Not over $500,00020% of the amount on line 1e.
Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
Over $17,000,000$1,000,000.
g Grassroots nontaxable amount (enter 25% of line 1f) ................................................. 250,000  
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................................................ 0  
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................................................ 0  
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ...................................................................................................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
Calendar year (or fiscal year
beginning in)
(a) 2016 (b) 2017 (c) 2018 (d) 2019 (e) Total
2a Lobbying nontaxable amount 1,000,000 1,000,000 1,000,000 1,000,000 4,000,000
b Lobbying ceiling amount
(150% of line 2a, column(e))
6,000,000
c Total lobbying expenditures 96,000 96,000 96,000 96,000 384,000
d Grassroots nontaxable amount 250,000 250,000 250,000 250,000 1,000,000
e Grassroots ceiling amount
(150% of line 2d, column (e))
1,500,000
f Grassroots lobbying expenditures          
Schedule C (Form 990 or 990-EZ) 2019


Schedule C (Form 990 or 990-EZ) 2019
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
Yes|No
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? ...........................................................................................................
 
 
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........
 
 
c
Media advertisements? ...................................................................................................
 
 
 
d
Mailings to members, legislators, or the public? .............................................................................
 
 
 
e
Publications, or published or broadcast statements? ...........................................................
 
 
 
f
Grants to other organizations for lobbying purposes? ..........................................................
 
 
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? .......................
 
 
 
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................
 
 
 
i
Other activities? ...................................................................................................................
 
 
 
j
Total. Add lines 1c through 1i ....................................................................................................
 
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
 
b
If "Yes," enter the amount of any tax incurred under section 4912 ...........................................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ...............................................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members ......................................................................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).
a
Current year .............................................................................................................................
2a
 
b
Carryover from last year ............................................................................................................
2b
 
c
Total ...........................................................................................................................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................
4
 
5
Taxable amount of lobbying and political expenditures (see instructions) .........................................
5
 
Part IV
Supplemental Information
Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.
Return Reference Explanation
Schedule C (Form 990 or 990EZ) 2019


Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet Attach to Form 990.
SchDMd Bullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate value of contributions to (during year)    
3 Aggregate value of grants from (during year)    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ...................... 2a  
b Total acreage restricted by conservation easements .................... 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............
6
Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenue included on Form 990, Part VIII, line 1 .........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:
a
Revenue included on Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2019

Schedule D (Form 990) 2019
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b If "Yes," explain the arrangement in Part XIII and complete the following table: Amount
c Beginning balance ............................. 1c  
d Additions during the year ............................ 1d  
e Distributions during the year .......................... 1e  
f Ending balance ................................ 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...
b
If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....
Part V
Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.
(a) Current year (b) Prior year (c) Two years back (d) Three years back (e) Four years back
1a Beginning of year balance .... 723,759 626,264 666,302 612,777  
b Contributions ... 15,000 45,000 10,100   596,343
c Net investment earnings, gains, and losses 51,845 54,479 12,604 61,326 18,408
d Grants or scholarships ...          
e Other expenditures for facilities
and programs ...
177 1,984 62,742 7,801 1,974
f Administrative expenses ....          
g End of year balance ...... 790,427 723,759 626,264 666,302 612,777
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet100.000 %
c
Term endowment SchDMd Bullet  
The percentages on lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) Unrelated organizations .................
3a(i)
 
No
(ii) Related organizations .................
3a(ii)
Yes
 
b
If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
Yes
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis
(investment)
(b) Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .....   5,288,315 5,288,315
b Buildings ....   230,031,218 79,080,268 150,950,950
c Leasehold improvements   101,150 101,150 0
d Equipment ....   63,475,432 51,952,294 11,523,138
e Other .....   2,807,208 95,909 2,711,299
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..SchDMdBullet 170,473,702
Schedule D (Form 990) 2019

Schedule D (Form 990) 2019
Page 3
Part VII
Investments—Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)
(b) Book value (c) Method of valuation:
Cost or end-of-year market value
(1) Financial derivatives.........    
(2) Closely-held equity interests........    
(3)Other
(B)
(C)
(D)
(E)
(F)
(G)
(H)
(I)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet  
Part VIII
Investments—Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(1)PLEDGED SECURITIES 99,600,000
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet 99,600,000
Part X
Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
(1) Federal income taxes  
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 116,481,853
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII
Schedule D (Form 990) 2019

Schedule D (Form 990) 2019
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ....... 1 81,110,900
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains (losses) on investments .... 2a 51,845
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d -99,642
e Add lines 2a through 2d ..................... 2e -47,797
3 Subtract line 2e from line 1.................. 3 81,158,697
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a  
b Other (Describe in Part XIII.) ........... 4b 7,732,981
c Add lines 4a and 4b.................... 4c 7,732,981
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 88,891,678
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ........... 1 113,688,539
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities ......... 2a  
b Prior year adjustments ............ 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d 26,991,750
e Add lines 2a through 2d.................... 2e 26,991,750
3 Subtract line 2e from line 1................... 3 86,696,789
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a  
b Other (Describe in Part XIII.) ............ 4b 7,732,981
c Add lines 4a and 4b..................... 4c 7,732,981
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 94,429,770
Part XIII
Supplemental Information
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Return Reference Explanation
PART X, LINE 2: PART X, LINE 1(1) AND LINE 2: THERE ARE NO UNCERTAIN TAX POSITIONS RELATED TO VARI.
PART XI, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 109,961. FUNDRAISING EVENT EXPENSE 56,986. ROYALTIES PAYOUT -371. ADDITIONAL IMPAIRMENT -266,743. GAMING EXPENSE 525.
PART XI, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 7,725,025. BAD DEBT ADJUSTMENT 7,956.
PART XII, LINE 2D - OTHER ADJUSTMENTS: RENTAL EXPENSES 109,961. FUNDRAISING EVENT EXPENSE 56,986. LOSS ON INTEREST RATE SWAP 27,091,392. ROYALTIES PAYOUT -371. ADDITIONAL IMPAIRMENT -266,743. GAMING EXPENSE 525.
PART XII, LINE 4B - OTHER ADJUSTMENTS: NET ALLOCATED 7,725,025. BAD DEBT ADJUSTMENT 7,956.
PART V VAN ANDEL INSTITUTE (A RELATED ORGANIZATION) MAINTAINS ENDOWED FUNDS FOR THE BENEFIT OF BOTH VARI AND VAN ANDEL EDUCATION INSTITUTE (A RELATED ORGANIZATION) TO FUND OPERATING EXPENSES.
PART XI AND XII, LINE 4B EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE.
Schedule D (Form 990) 2019


Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990.Right pointing arrow large image Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in the region (d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in the region
(f) Total expenditures
for and investments
in the region
EUROPE 0 0 PROGRAM SERVICES RESEARCH COLLABORATION - RESEARCH SERVICES, GUEST SPEAKING 136,402
EUROPE 0 0 FUNDRAISING   3,550
NORTH AMERICA 0 0 PROGRAM SERVICES GUEST SPEAKING 5,000
           
           
           
           
           
           
           
           
           
           
           
           
           
           
3a Sub-total .... 0 0 144,952
b Total from continuation sheets to Part I ... 0 0 0
c Totals (add lines 3a and 3b) 0 0 144,952
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2019
Schedule F (Form 990) 2019
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)
(c) Region (d) Purpose of
grant
(e) Amount of
cash grant
(f) Manner of
cash
disbursement
(g) Amount
of noncash
assistance
(h) Description
of noncash
assistance
(i) Method of
valuation
(book, FMV,
appraisal, other)
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
 
3 Enter total number of other organizations or entities .......................MediumBullet
 
Schedule F (Form 990) 2019
Schedule F (Form 990) 2019Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant
(e) Manner of cash
disbursement
(f) Amount of
noncash
assistance
(g) Description
of noncash
assistance
(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2019
Schedule F (Form 990) 2019
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2019
Schedule F (Form 990) 2019
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
ReturnReference Explanation
PART I, LINE 2: GRANT FUNDS ARE MONITORED BY QUARTERLY EXPENDITURE REPORTS BEFORE DISBURSING INCREMENTAL FUNDING. PROGRESS REPORTS ARE REQUIRED ANNUALLY AND REVIEWED BY VAN ANDEL RESEARCH INSTITUTE AND A THIRD PARTY.
PART III ACCOUNTING METHOD:  
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2019
Additional Data


Software ID:  
Software Version:  



SCHEDULE G (Form 990 or 990-EZ)
Department of the Treasury
Internal Revenue Service
Supplemental Information Regarding
Fundraising or Gaming Activities
Complete if the organization answered "Yes" on Form 990, Part IV, lines 17, 18, or 19, or if the organization entered more than $15,000 on Form 990-EZ, line 6a. right arrowAttach to Form 990 or Form 990-EZ.
right arrowGo to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Fundraising Activities.Complete if the organization answered "Yes" on Form 990, Part IV, line 17.
Form 990-EZ filers are not required to complete this part.
1
Indicate whether the organization raised funds through any of the following activities. Check all that apply.
a e
b f
c g
d
2a
Did the organization have a written or oral agreement with any individual (including officers, directors, trustees
or key employees listed in Form 990, Part VII) or entity in connection with professional fundraising services?
b
If "Yes," list the 10 highest paid individuals or entities (fundraisers) pursuant to agreements under which the fundraiser is
to be compensated at least $5,000 by the organization.


(i) Name and address of individual
or entity (fundraiser)
(ii) Activity (iii) Did fundraiser have custody or control of contributions? (iv) Gross receipts
from activity
(v) Amount paid to
(or retained by)
fundraiser listed in
col. (i)
(vi) Amount paid to
(or retained by)
organization
Yes No
             
             
             
             
             
             
             
             
             
             
Total . . . . . . . . . . . . . . . . . . . . right arrow      
3
List all states in which the organization is registered or licensed to solicit contributions or has been notified it is exempt from registration or licensing.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 50083H
Schedule G (Form 990 or 990-EZ) 2019
Schedule G (Form 990 or 990-EZ) 2019
Page 2
Part II
Fundraising Events. Complete if the organization answered "Yes" on Form 990, Part IV, line 18, or reported more than $15,000 of fundraising event contributions and gross income on Form 990-EZ, lines 1 and 6b. List events with gross receipts greater than $5,000.









VerticalRevenue
(a) Event #1

SOUTHSIDE
(event type)
(b) Event #2

NYC MARATHON
(event type)
(c) Other events

2
(total number)
(d) Total events
(add col. (a) through col. (c))

1

Gross receipts . . . . .

51,753

16,559

22,604

90,916

2

Less: Contributions . . . .

50,376

16,559

20,689

87,624
3 Gross income (line 1 minus
line 2) . . . . . .

1,377

 

1,915

3,292



VerticalDirectExpenses
4 Cash prizes . . . . .        
5 Noncash prizes . . . .        
6 Rent/facility costs . . . .        
7 Food and beverages . . .        
8 Entertainment . . . .        
9 Other direct expenses . . . 16,038 17,727 8,712 42,477
10 Direct expense summary. Add lines 4 through 9 in column (d) . . . . . . . . . . right arrow 42,477
11 Net income summary. Subtract line 10 from line 3, column (d). . . . . . . . . . right arrow -39,185
Part III
Gaming. Complete if the organization answered "Yes" on Form 990, Part IV, line 19, or reported more than $15,000 on Form 990-EZ, line 6a.
VerticalRevenue
(a) Bingo (b) Pull tabs/Instant
bingo/progressive bingo
(c) Other gaming (d) Total gaming (add col.(a) through col.(c))

1

Gross revenue . . . . .

 

 

 

 
VerticalDirectExpenses

2

Cash prizes . . . . .

 

 

 

 

3

Noncash prizes . . . .

 

 

 

 

4

Rent/facility costs . . . .

 

 

 

 

5

Other direct expenses . . .

 

 

 

 


6


Volunteer labor . . . .
%
%
%


7

Direct expense summary. Add lines 2 through 5 in column (d) . . . . . . . . . . right arrow

 

8

Net gaming income summary. Subtract line 7 from line 1, column (d). . . . . . . . . right arrow

 

9
Enter the state(s) in which the organization conducts gaming activities:
a
Is the organization licensed to conduct gaming activities in each of these states? . . . . . . . .
b
If "No," explain:
 
10a
Were any of the organization's gaming licenses revoked, suspended or terminated during the tax year? . . .
b
If "Yes," explain:
 
Schedule G (Form 990 or 990-EZ) 2019
Schedule G (Form 990 or 990-EZ) 2019
Page 3
11
Does the organization conduct gaming activities with nonmembers? . . . . . . . . . . .
12
Is the organization a grantor, beneficiary or trustee of a trust or a member of a partnership or other entity
formed to administer charitable gaming? . . . . . . . . . . . . . . . . .
13
Indicate the percentage of gaming activity conducted in:
a
The organization's facility . . . . . . . . . . . . . . . . . .
13a
%
b
An outside facility . . . . . . . . . . . . . . . . . . . .
13b
%
14
Enter the name and address of the person who prepares the organization's gaming/special events books and records:
Name right arrow
Address right arrow
15a
Does the organization have a contract with a third party from whom the organization receives gaming
revenue? . . . . . . . . . . . . . . . . . . . . . . . .
b
If "Yes," enter the amount of gaming revenue received by the organization right arrow $   and the
amount of gaming revenue retained by the third party right arrow $   .
c
If "Yes," enter name and address of the third party:
Name right arrow
Address right arrow
16
Gaming manager information:
Name right arrow
Gaming manager compensation right arrow $  
Description of services provided right arrow
 
17
Mandatory distributions:
a
Is the organization required under state law to make charitable distributions from the gaming proceeds to
retain the state gaming license? . . . . . . . . . . . . . . . . . . .
b
Enter the amount of distributions required under state law distributed to other exempt organizations or spent
in the organization's own exempt activities during the tax year right arrow$  
Part IV
Supplemental Information. Provide the explanations required by Part I, line 2b, columns (iii) and (v); and Part III, lines 9, 9b, 10b, 15b, 15c, 16, and 17b, as applicable. Also provide any additional information. See instructions.
Return Reference Explanation
Schedule G (Form 990 or 990-EZ) 2019
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Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990.
lBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2019
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number
52-2000823
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient
that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government
(b) EIN (c) IRC section
(if applicable)
(d) Amount of cash grant (e) Amount of non-cash
assistance
(f) Method of valuation
(book, FMV, appraisal,
other)
(g) Description of
noncash assistance
(h) Purpose of grant
or assistance
(1) MICHIGAN STATE UNIVERSITY
535 CHESTNUT ROAD ROOM 300
EAST LANSING,MI48824
38-6005984 501C3 5,245       SUPPORT FOR TRANSLATIONAL NEUROSCIENCE FUND
(2) STAND UP TO CANCER
10880 WILSHIRE BLVD SUITE 1400
LOS ANGELES,CA90024
95-1644609 501C3 1,875,000       RESEARCH COLLABORATION
(3) FRIENDS OF CRESCENT PARK
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI49503
26-4562012 501C3 20,500       SUPPORT MAINTENANCE OF CRESCENT PARK
2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image
3
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
0
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2019

Schedule I (Form 990) 2019
Page 2
Part III
Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Number of
recipients
(c) Amount of
cash grant
(d) Amount of
noncash assistance
(e) Method of valuation (book,
FMV, appraisal, other)
(f) Description of noncash assistance
(1) GRADUATE STUDENT STIPENDS FOR MICHIGAN STATE UNIVERSITY STUDENTS 1 46,638      
(2) GRADUATE STUDENT STIPENDS VAN ANDEL INSTITUTE GRADUATE SCHOOL 9 100,650      
(3) FOREIGN NATIONAL STIPENDS 3 71,000      
(4) GUEST WORKER STIPENDS 6 72,377      
(5) VAN ANDEL INSTITUTE GRADUATE SCHOOL STUDENT TUITION AND FEES REMISSION 31   222,083   TUITION REMISSION.
(5)
(6)
(7)
Part IV
Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.
Return Reference Explanation
PART I, LINE 2: STUDENTS RECEIVE A STIPEND FOR LIVING EXPENSE AND INSURANCE. GRANT FUNDS TO INSTITUTIONS ARE MONITORED BY QUARTERLY EXPENDITURE REPORTS BEFORE DISBURSING INCREMENTAL FUNDING. PROGRESS REPORTS ARE REQUIRED ANNUALLY AND REVIEWED BY VAN ANDEL RESEARCH INSTITUTE AND A THIRD PARTY.
Schedule I (Form 990) 2019



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Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet Attach to Form 990.
SchJMediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .........
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ..
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? .............
4a
 
No
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.
5
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ....................
5a
Yes
 
b
Any related organization? .......................
5b
 
No
If "Yes," on line 5a or 5b, describe in Part III.
6
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ..................
6a
 
No
b
Any related organization? ......................
6b
 
No
If "Yes," on line 6a or 6b, describe in Part III.
7
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
 
No
8
Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................
8
 
No
9
If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2019

Schedule J (Form 990) 2019
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits
(E) Total of columns
(B)(i)-(D)
(F) Compensation in column (B) reported as deferred on prior Form 990
(i) Base
compensation
(ii) Bonus & incentive
compensation
(iii) Other reportable compensation
1DAVID VAN ANDEL
CHAIRMAN / CEO
(i)

(ii)
401,538
-------------
0
97,500
-------------
0
21,218
-------------
0
155,750
-------------
0
1,096
-------------
0
677,102
-------------
0
97,500
-------------
0
2DR JANA HALL
CHIEF OPERATIONS OFFICER
(i)

(ii)
388,026
-------------
0
72,109
-------------
0
3,574
-------------
0
134,549
-------------
0
10,840
-------------
0
609,098
-------------
0
72,109
-------------
0
3TIMOTHY MYERS
V.P. & CHIEF FINANCIAL OFFICER
(i)

(ii)
296,026
-------------
0
46,929
-------------
0
1,242
-------------
0
88,750
-------------
0
10,840
-------------
0
443,787
-------------
0
46,929
-------------
0
4DR PETER JONES
CHIEF SCIENTIFIC OFFICER & RES. DIR.
(i)

(ii)
598,247
-------------
0
130,332
-------------
0
23,954
-------------
0
224,888
-------------
0
10,840
-------------
0
988,261
-------------
0
130,332
-------------
0
5THOMAS CURRAN JR
GENERAL COUNSEL
(i)

(ii)
256,604
-------------
0
17,672
-------------
0
2,467
-------------
0
69,757
-------------
0
10,840
-------------
0
357,340
-------------
0
0
-------------
0
6GERALD CALLAHAN
CHIEF STRATEGIC OFFICER
(i)

(ii)
312,589
-------------
0
48,907
-------------
0
20,242
-------------
0
114,752
-------------
0
10,840
-------------
0
507,330
-------------
0
0
-------------
0
7KATHY VOGELSANG
CHIEF INVESTMENT OFFICER
(i)

(ii)
471,142
-------------
0
249,830
-------------
0
21,322
-------------
0
428,000
-------------
0
10,840
-------------
0
1,181,134
-------------
0
249,830
-------------
0
8DR PATRIK BRUNDIN
ASSOCIATE RESEARCH DIRECTOR
(i)

(ii)
478,481
-------------
0
48,967
-------------
0
2,322
-------------
0
106,535
-------------
0
10,840
-------------
0
647,145
-------------
0
48,967
-------------
0
9DR PETER LAIRD
DISTINGUISHED INVESTIGATOR
(i)

(ii)
412,004
-------------
0
16,407
-------------
0
3,564
-------------
0
63,792
-------------
0
10,840
-------------
0
506,607
-------------
0
16,407
-------------
0
10TED HEILMAN
ASSOC DIRECT-SR. PORTFOLIO MGR.
(i)

(ii)
254,219
-------------
0
142,760
-------------
0
21,322
-------------
0
252,154
-------------
0
10,840
-------------
0
681,295
-------------
0
142,760
-------------
0
11DR GERD PFEIFER
SR. SCIENTIFIC INVESTIGATOR
(i)

(ii)
371,239
-------------
0
10,124
-------------
0
3,564
-------------
0
36,763
-------------
0
10,840
-------------
0
432,530
-------------
0
0
-------------
0
Schedule J (Form 990) 2019

Schedule J (Form 990) 2019
Page 3
Part III
Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.
Return Reference Explanation
PART I, LINE 1A VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES.
PART I, LINE 5 BONUS IS PAID BASED ON VARIABLE PAY PROGRAM OBJECTIVES FOR ELIGIBLE PROGRAM PARTICIPANTS.
Schedule J (Form 990) 2019

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Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax-Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part , line 24a. Provide descriptions,
explanations, and any additional information in Part .
SchKMediumBullet Attach to Form 990.

SchKMediumBulletGo to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2019
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number
52-2000823
Part
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer
(i) Pool
financing
Yes No Yes No Yes No
A MICHIGAN STRATEGIC FUND
 
52-1417332 000000000 10-01-2018 220,000,000 REFUND BOND ISSUE 4/01/13   X   X   X
Part
Proceeds
A B C D
1 Amount of bonds retired ..................        
2 Amount of bonds legally defeased ..............        
3 Total proceeds of issue .................. 220,000,000      
4 Gross proceeds in reserve funds .............        
5 Capitalized interest from proceeds .............        
6 Proceeds in refunding escrows ...............        
7 Issuance costs from proceeds ...............        
8 Credit enhancement from proceeds .............        
9 Working capital expenditures from proceeds .............        
10 Capital expenditures from proceeds .............        
11 Other spent proceeds ............. 220,000,000      
12 Other unspent proceeds .............        
13 Year of substantial completion .............
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue of tax-exempt
bonds (or, if issued prior to 2018, a current refunding issue)? ........
X              
15 Were the bonds issued as part of an advance refunding issue of taxable
bonds (or, if issued prior to 2018, an advance refunding issue)? ........
  X            
16 Has the final allocation of proceeds been made? .......... X              
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? .................. X              
Part
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............   X            
2 Are there any lease arrangements that may result in private business use of bond-financed property? ............... X              
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2019

Schedule K (Form 990) 2019
Page 2
Part
Private Business Use (Continued)
A B C D
Yes No Yes No Yes No Yes No
3a Are there any management or service contracts that may result in private business use of bond-financed property? ............. X              
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property? X              
c Are there any research agreements that may result in private business use of bond-financed property? ............. X              
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? X              
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....SchKMediumBullet        
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government ......... SchKMediumBullet 0.210 %      
6 Total of lines 4 and 5 ............. 0.210 %      
7 Does the bond issue meet the private security or payment test? ...   X            
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?............. X              
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. .. 0.560 %      
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............   X            
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2? ........
X              
Part
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ...   X            
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......   X            
b Exception to rebate? ........   X            
c No rebate due? ......... X              
If "Yes" to line 2c, provide in Part the date the rebate
computation was performed ......
3 Is the bond issue a variable rate issue? ..... X              
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?   X            
b Name of provider ..........  
 
 
 
 
 
 
 
c Term of hedge .........        
d Was the hedge superintegrated? ......                
e Was the hedge terminated? ........                
Schedule K (Form 990) 2019

Schedule K (Form 990) 2019
Page 3
Part
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?   X            
b Name of provider ..........  
 
 
 
 
 
 
 
c Term of GIC .........        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........                
6 Were any gross proceeds invested beyond an available temporary period?   X            
7 Has the organization established written procedures to monitor the requirements of section 148? ... X              
Part
Procedures To Undertake Corrective Action
--------------------------------------------------------------------------------------------------------------- A B C D
Yes No Yes No Yes No Yes No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations? X              
Part
Supplemental Information. Provide additional information for responses to questions on Schedule K. (See instructions).
Return Reference Explanation
DATE REBATE COMPUTATION PERFORMED ISSUER NAME: MICHIGAN STRATEGIC FUND DATE THE REBATE COMPUTATION WAS PERFORMED: 10/01/2018
PAGE 2 PART III LINE 8C NO REMEDIAL ACTION WAS REQUIRED BECAUSE NO BONDS BECAME UNQUALIFIED DUE TO THE DISPOSITION.
Schedule K (Form 990) 2019

Additional Data


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SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
MediumBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2019
Open to Public
Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Return Reference Explanation
FORM 990, PART VI, SECTION A, LINE 2 VARI, VAI, VAEI, AND VAIGS SHARE COMMON MANAGEMENT. DAVID VAN ANDEL, DR. JANA HALL AND TIMOTHY MYERS ARE ALSO OFFICERS OF VAI, AND DAVID VAN ANDEL AND TIMOTHY MYERS ARE OFFICERS OF VAEI AND VAIGS. THOMAS CURRAN JR. IS ALSO AN OFFICER OF VAIGS. GERALD CALLAHAN AND THOMAS CURRAN JR. ARE KEY EMPLOYEES OF VAI AND VAEI.
FORM 990, PART VI, SECTION A, LINE 2 BUSINESS RELATIONSHIP: DAVID VAN ANDEL, GERALD CALLAHAN
FORM 990, PART VI, SECTION A, LINE 7A THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY.
FORM 990, PART VI, SECTION B, LINE 11B FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD FOR REVIEW AND COMMENTS PRIOR TO FILING WITH THE IRS.
FORM 990, PART VI, SECTION B, LINE 12C VARI HAS WRITTEN CONFLICT OF INTEREST ("COI") POLICIES AND PROCEDURES WHICH ADMINISTER AND ENFORCE A PROCESS TO IDENTIFY, EVALUATE, AND MANAGE POTENTIAL CONFLICTS OF INTEREST. THESE POLICIES HAVE BEEN APPROVED BY THE BOARD OF TRUSTEES. VAI ADMINISTERS COI POLICIES AND PROCEDURES THROUGH TWO STANDING COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). COI POLICIES AND PROCEDURES APPLY TO AND SERVE AS A GUIDE FOR EVERYONE IN THE ORGANIZATION. IN PARTICULAR, THEY PROVIDE A USEFUL RESOURCE FOR DEVELOPING ACTIVITIES OR RELATIONSHIPS WITH OUTSIDE ENTITIES OR PERSONS, AND ESTABLISH A PROCESS FOR COMMITTEES TO REVIEW AND MANAGE POTENTIAL CONFLICTS OF INTEREST AS THEY MAY ARISE. THE CC AND ICOIC ARE CHAIRED BY THE GENERAL COUNSEL. THE CC REQUIRES ANNUAL AND UPDATED DISCLOSURES BY COVERED PERSONS AND REVIEWS AND APPROVES MANAGEMENT PLANS. ICOIC POLICIES AND PROCEDURES SERVE AS A GUIDE FOR BOARDS OF TRUSTEES AND SENIOR EXECUTIVES. IN THE EVENT A POTENTIAL COI ARISES AT THE BOARD OR SENIOR EXECUTIVE LEVEL, THE ICOIC MEETS TO REVIEW AND DETERMINE HOW TO MANAGE SUCH A POTENTIAL CONFLICT OF INTEREST IN ACCORDANCE WITH THE COI POLICIES AND PROCEDURES.
FORM 990, PART VI, SECTION B, LINE 15 COMPARABILITY DATA FROM AN EXPERT THIRD PARTY IS OBTAINED AND REVIEWED BY THE INDEPENDENT, JOINT COMPENSATION COMMITTEE OF VAN ANDEL RESEARCH INSTITUTE AND RELATED ORGANIZATIONS TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE.
FORM 990, PART VI, SECTION C, LINE 19 ALL DOCUMENTS REQUIRED TO BE MADE AVAILABLE TO THE PUBLIC ARE AVAILABLE FOR PUBLIC INSPECTION UPON WRITTEN REQUEST.
FORM 990, PART XI, LINE 9: LOSS ON INTEREST RATE SWAP -27,091,392.
FORM 990, PART III, LINE 2 VAN ANDEL RESEARCH INSTITUTE (VARI) IS DEDICATED TO DETERMINING THE EPIGENETIC, GENETIC, MOLECULAR, AND CELLULAR ORIGINS OF CANCER, PARKINSON'S DISEASE, METABOLIC DISORDERS, AND OTHER ILLNESSES AND TO TRANSLATING THOSE FINDINGS INTO EFFECTIVE THERAPIES. THE INSTITUTE'S SCIENTISTS WORK IN ON-SITE LABORATORIES AND PARTICIPATE IN COLLABORATIONS THAT SPAN THE GLOBE. WITH EPIGENETICS AS ITS COMMON THREAD, THE INSTITUTE IS ORGANIZED INTO THE CENTER FOR CANCER AND CELL BIOLOGY, THE CENTER FOR EPIGENETICS, AND THE CENTER FOR NEURODEGENERATIVE SCIENCE. THE INSTITUTE'S LABS ARE SUPPORTED BY AN OUTSTANDING CORE TECHNOLOGIES AND SERVICES GROUP, WHICH PROVIDES A VIVARIUM, A BIOREPOSITORY, AND VALUABLE ON-SITE CAPABILITIES IN BIOINFORMATICS AND BIOSTATISTICS, CRYO-ELECTRON MICROSCOPY, FLOW CYTOMETRY, IMAGING, GENOMICS, METABOLOMICS AND BIOENERGETICS, PATHOLOGY, AND TRANSGENICS. VARI SCIENTISTS PUBLISHED 136 ARTICLES IN THIS FISCAL YEAR IN PEER-REVIEWED JOURNALS THAT INCLUDED NATURE, CELL, CELL REPORTS, ELIFE, NATURE COMMUNICATIONS, NATURE STRUCTURAL AND MOLECULAR BIOLOGY, CELL METABOLISM, NEUROLOGY, CELL STEM CELL, CANCER CELL, CANCER RESEARCH, MOVEMENT DISORDERS, CHEMICAL SCIENCE, MOLECULAR CELL, CIRCULATION RESEARCH, NATURE NEUROSCIENCE, LANCET NEUROLOGY, ISCIENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES U.S.A., ONCOGENE, CLINICAL CANCER RESEARCH, NEURO-ONCOLOGY, NATURE MATERIALS, BLOOD, EUROPEAN JOURNAL OF NEUROLOGY, CYTOMETRY A, TRENDS IN NEUROSCIENCES, GENOME BIOLOGY, PLOS COMPUTATIONAL BIOLOGY, PLOS GENETICS, JOURNAL OF BIOLOGICAL CHEMISTRY, JOURNAL OF VETERINARY INTERNAL MEDICINE, MOLECULAR CANCER THERAPEUTICS, GENES, NEUROBIOLOGY OF DISEASE, CELL REPORTS MEDICINE, CRISPR JOURNAL, EMBO REPORTS, SCIENTIFIC REPORTS, STRUCTURE, FASEB JOURNAL, CALCIFIED TISSUE INTERNATIONAL, EPIGENETICS AND CHROMATIN, JOURNAL OF MOLECULAR BIOLOGY, JOURNAL OF PARKINSON'S DISEASE, BIOCHEMICAL JOURNAL, JOURNAL OF CLINICAL MEDICINE, BIOANALYSIS, AND JOURNAL OF CHEMICAL PHYSICS.
FORM 990, PART III, LINE 4A LINE 4A - PROGRAM SERVICE ACTIVITY #1 CENTER FOR CANCER AND CELL BIOLOGY THE CENTER FOR CANCER AND CELL BIOLOGY, DIRECTED BY BART WILLIAMS, PH.D., COMPRISES 14 LABORATORIES ENGAGED IN BASIC RESEARCH IN MOLECULAR AND STRUCTURAL BIOLOGY AND IN TRANSLATIONAL RESEARCH ON CANCER, SKELETAL DISEASES, AND METABOLISM AND NUTRITION. THE CENTER IS DIVIDED INTO PROGRAMS IN STRUCTURAL BIOLOGY; SKELETAL DISEASE AND CANCER THERAPEUTICS; AND METABOLIC AND NUTRITIONAL PROGRAMMING. IN THIS FISCAL YEAR, RESEARCHERS AND TRAINEES WITHIN THE CENTER RECEIVED TWO R01 AWARDS, TWO R35 AWARDS, AN R21 AWARD, AND AN F99 FELLOWSHIP FROM THE NATIONAL INSTITUTES OF HEALTH. OTHER NEW GRANTS WERE FROM THE PEW CHARITABLE TRUSTS, THE SLOAN FOUNDATION, AND THE BREAST CANCER RESEARCH FOUNDATION. TWO NON-NIH POSTDOCTORAL FELLOWSHIPS WERE ALSO RECEIVED, FROM THE AMERICAN HEART ASSOCIATION AND THE AMERICAN CANCER SOCIETY. THE WILLIAMS LAB PRODUCED SEVERAL STUDIES ON BONE-RELATED ISSUES. A PROJECT ON GALECTIN-3 UNCOVERED THE MECHANISM FOR SEX-DEPENDENT EFFECTS OF LOSS OF THIS MOLECULE ON AGING BONE. GALECTIN-3 MAY BE A THERAPEUTIC TARGET AGAINST THE LOSS OF SEX HORMONE PRODUCTION SUCH AS OCCURS FOLLOWING MENOPAUSE IN WOMEN OR IN ANDROGEN DEPLETION THERAPY FOR PROSTATE CANCER PATIENTS (MAUPIN ET AL., CALCIFIED TISSUE INTERNATIONAL 106(3): 283-293). ANOTHER STUDY RELATED TO INDIVIDUALS WHO HAVE LOST THE FUNCTION OF THE LRP5 PROTEIN; THEY DEVELOP OSTEOPOROSIS AND DEFECTIVE RETINAL VASCULATURE. THE LAB USED CRISPR-CAS9 TECHNOLOGY TO KNOCK OUT THE LRP5 GENE IN RATS, WHICH PROVIDES A NEW MODEL FOR STUDYING THE ROLE OF WNT SIGNALING IN THE DEVELOPMENT OF BONE AND THE RETINA, AS WELL AS FOR RESEARCH INTO HOW TO TREAT PATIENTS WHO HAVE MUTANT FORMS OF LRP5 (UBELS ET AL., CRISPR JOURNAL 3(4): 284-298). THE LAB ALSO COLLABORATED WITH A JOHNS HOPKINS LABORATORY TO STUDY THE FRIZZLED-4 (FZD4) RECEPTOR PROTEIN. THE DATA SHOWED THAT FZD4 MAY HAVE OVERLAPPING FUNCTIONS WITH FZD8, BUT THAT FZD4 IS REQUIRED FOR NORMAL BONE DEVELOPMENT AND MINERALIZATION (KUSHWAHA ET AL., JOURNAL OF CELL PHYSIOLOGY 235(10): 6673-6683). IN THE STRUCTURAL BIOLOGY PROGRAM, THE LI LAB PUBLISHED THE FIRST CRYOELECTRON MICROSCOPY STRUCTURE OF THE EUKARYOTIC ENDOPLASMIC RETICULUM MEMBRANE COMPLEX, WHICH INSERTS PROTEINS THROUGH A MEMBRANE. PART OF THE STRUCTURE RESEMBLES A PROKARYOTIC INSERTASE ENZYME, SHOWING CONSERVATION OF STRUCTURE THROUGHOUT EVOLUTION AND SUGGESTING THAT THEIR ENZYME MECHANISMS MAY BE SIMILAR (BAI ET AL., NATURE 584(7821): 475-478). ANOTHER PAPER REPORTED A HIGH-RESOLUTION STRUCTURE FOR THE EUKARYOTIC CMG HELICASE. DETAILS OF THE STRUCTURE ALLOWED THE AUTHORS TO DESCRIBE HOW THE HELICASE PULLS THE DNA THROUGH A MOLECULAR TUNNEL, ALLOWING IT TO SEPARATE THE TWO DNA STRANDS FOR REPLICATION (YUAN ET AL., NATURE COMMUNICATIONS 11: 688). A THIRD PROJECT PRODUCED AN ATOMIC STRUCTURE FOR THE POLYMERASE EPSILON ENZYME, WHICH IS A DIMER OF TWO DIFFERENT POL "MODULES". THE SOLVED STRUCTURE SUGGESTS THAT A FOLD IN THE DBP2 SUBUNIT DIRECTS THE DNA LEADING STRAND FROM THE CMG COMPLEX TO THE POL EPISILON ACTIVE SITE (YUAN ET AL., NATURE COMMUNICATIONS 11: 356). THESE LAST TWO PAPERS TOGETHER SHED NEW LIGHT ON THE ATOMIC-LEVEL MECHANISM OF HOW DNA IS REPLICATED IN THE CELL. THE DU AND LU LABS PUBLISHED THREE PAPERS IN THE PRESTIGIOUS JOURNAL NATURE ON THE STRUCTURES OF ION CHANNELS, WHICH ARE PROTEINS THAT ALLOW IONS INTO AND OUT OF CELLS. THEY PUBLISHED STRUCTURES FOR THE HUMAN CALHM2 ION CHANNEL IN AN ACTIVE AND AN INHIBITED STATE. THEY ALSO PROPOSED A GATING MECHANISM FOR CALHM2 IN WHICH THE S1 HELIX COARSELY ADJUSTS, AND THE N-TERMINAL HELIX FINE-TUNES, THE PORE SIZE (CHOI ET AL., NATURE 576(7785): 163-167). PANNEXIN IS A PROTEIN INVOLVED IN BLOOD PRESSURE REGULATION AND OTHER IMPORTANT PROCESSES. THE LABS SOLVED THE STRUCTURES OF HUMAN PANNEXIN 1 (PANX1) IN THREE STATES, AT DOWN TO 2.8-ANGSTROM RESOLUTION. THEY WERE ABLE TO DESCRIBE ITS GATING MECHANISM FOR TWO DIFFERENT ION PATHWAYS, AS WELL AS THE ROLE OF CARBENOXOLONE AS A BLOCKER OF THE PANNEXIN CHANNEL (RUAN ET AL., NATURE 584(7822): 646-651). FINALLY, THEY ALSO STUDIED THE PROTON-ACTIVATED CHLORIDE CHANNEL (PAC), WHICH IS INVOLVED IN TISSUE INJURY. THEIR PAPER DESCRIBED THE CHANGES OF PROTEIN CONFORMATION WITH A CHANGE IN PH IN THE CELLULAR ENVIRONMENT, AND ALSO THE MOLECULAR ASSEMBLY OF THE THREE PAC SUBUNITS. THESE RESULTS PROVIDE A BASIS FOR UNDERSTANDING THE ATOMIC-LEVEL MECHANISMS OF PAC (RUAN ET AL., NATURE 588(7837): 350-354). THE STRUCTURAL LAB OF KARSTEN MELCHER PUBLISHED SEVERAL PAPERS IN COLLABORATION WITH LABS AT VARI AND ELSEWHERE. METHYLTRANSFERASES ARE ENZYMES THAT PLACE METHYL GROUPS ONTO DNA, AN IMPORTANT EPIGENETIC MODIFICATION. THE LABS OF MELCHER AND PETER JONES SOLVED THE STRUCTURES OF TWO SUCH ENZYMES, DNMT3A AND DNMT3B, BOUND TO NUCLEOSOMES. THE STRUCTURES SUGGEST THAT IN ORDER TO ADD THE METHYL GROUP, THE DNA MUST BE MOVED RELATIVE TO THE NUCLEOSOME CORE (XU ET AL., NATURE 586(7827): 151-155). ANOTHER STUDY USED MOLECULAR DYNAMICS SIMULATIONS TO DETERMINE HOW THE DRUG FENTANYL BINDS TO THE MU-OPIOID RECEPTOR. THE RESULTS SUGGEST AN ACTIVATION MECHANISM AND PROVIDE A RATIONAL FRAMEWORK FOR IMPROVING THE SAFETY PROFILES OF FENTANYL-BASED ANALGESICS (DE WAAL ET AL., PLOS COMPUTATIONAL BIOLOGY 16(4): E1007394). THE MELCHER LAB ALSO STUDIED TWO G-PROTEIN-COUPLED RECEPTORS (GPCRS) CALLED CFR1R AND CFR2R, WHICH ARE ACTIVATED BY ENDOCRINE HORMONES AND ARE INVOLVED IN THE BODY'S STRESS RESPONSES. THE PEPTIDE-BINDING AMINO ACIDS IN THESE TWO RECEPTORS DIFFER FROM THOSE IN OTHER CLASS B GPCRS, AND BOTH STRUCTURES HAD BOUND CHOLESTEROL MOLECULES. THIS WORK PROVIDES A MODEL FOR STUDYING THE MEMBRANE PROTEIN-LIPID INTERACTIONS OF CLASS B GPCRS (MA ET AL., MOLECULAR CELL 77(3): 669-680.E4). FINALLY, THEY STUDIED THE CANNABINOID RECEPTOR CB2 AS A TARGET FOR TREATING NEURODEGENERATIVE DISORDERS AND FOR TREATING PAIN WITH FEWER SIDE EFFECTS. THE STRUCTURE OF THE HUMAN CB2-G(I) SIGNALING COMPLEX WAS SOLVED WITH A BOUND AGONIST, SHOWING THE BINDING MODE AND HOW CB2 DISTINGUISHES AGONISTS FROM ANTAGONISTS. THIS KNOWLEDGE SHOULD AID IN DEVELOPING MORE-EFFECTIVE DRUGS THAT TARGET THE CANNABINOID SYSTEM (XING ET AL., CELL 180(4): 645-654.E13). IN THE METABOLISM PROGRAM, THE RUSSELL JONES LAB INVESTIGATED THE METABOLIC ADAPTATION OF CANCER CELLS THROUGH THE LIVER KINASE B1-AMPK PATHWAY. THE MICRORNA MIR-17 SENSITIZED LYMPHOMA CELLS TO TREATMENT WITH BIGUANIDES, WHICH STRESS THE CELLS BY INHIBITING THE KREBS CYCLE AND MITOCHONDRIAL RESPIRATION. MIR-17 EXPRESSION MAY BE A BIOMARKER FOR BIGUANIDE SENSITIVITY IN CANCERS (IZREIG ET AL., CELL REPORTS MEDICINE 1(2): 100014). THE LAB ALSO INVESTIGATED THE REASONS FOR AND EFFECTS OF HIGH SERUM ACETATE AT SITES OF INFECTION. THEY FOUND THAT AN ABUNDANCE OF ACETATE IMPROVED PATHOGEN CLEARANCE WHILE REDUCING IMMUNOPATHOLOGY. OVERALL, THE WORK SHOWED THAT AT DIFFERENT STAGES OF THE IMMUNE RESPONSE, ACETATE HAS DISTINCTLY DIFFERENT EFFECTS WITHIN THE SAME CELL TYPE (BALMER ET AL., CELL METABOLISM 32(3): 457-467.E5). A THIRD PAPER REPORTED THE EFFECTS OF METHOTREXATE ON CELLULAR METABOLISM, ONE OF WHICH WAS AMPK ACTIVATION. THAT ACTIVATION WAS NECESSARY FOR BOTH THE ANTI-PROLIFERATIVE AND PRO-RESPIRATORY EFFECTS OF METHOTREXATE. COMBINING METHOTREXATE WITH THE AMPK ACTIVATOR PHENFORMIN POTENTIATES THE ANTI-PROLIFERATIVE ACTIVITY IN CANCER CELLS (PAPADOPOLI ET AL., SCIENTIFIC REPORTS 10(1): 7838). THE JONES AND KRAWCZYK LABS COLLABORATED IN A STUDY OF MICRORNA-9 IN THE DENDRITIC CELLS OF THE INNATE IMMUNE SYSTEM. THE RESULTS SHOWED THAT MIR-9 AIDED THE TRANSITION OF DENDRITIC CELLS FROM STEADY STATE TO A MATURE STATE BY AFFECTING THE EXPRESSION OF SEVERAL NEGATIVE REGULATORS OF CELL TRANSCRIPTION, INCLUDING POLYCOMB GROUP FACTOR 6 (CORDEIRO ET AL., CELL REPORTS 21(5): 107585). METHIONINE IS A KEY NUTRIENT AFFECTING EPIGENETIC REPROGRAMMING IN CD4+ T HELPER (TH) CELLS. A COLLABORATION AMONG THE R. JONES, KRAWCZYK, AND POSPISILIK LABS SHOWED THAT A LACK OF METHIONINE AFFECTED THE PROMOTER REGIONS OF GENES INVOLVED IN THE PROLIFERATION OF INFLAMMATORY TH17 CELLS AND CYTOKINE PRODUCTION. IN A MOUSE MODEL OF MULTIPLE SCLEROSIS, LACK OF DIETARY METHIONINE LED TO REDUCED T CELL-MEDIATED NEUROINFLAMMATION AND DISEASE ONSET. METHIONINE RESTRICTION MAY BE A USEFUL INTERVENTION FOR TREATING AUTOIMMUNE CONDITIONS SUCH AS MS (ROY ET AL., CELL METABOLISM 31(2): 250-266.E9). FINALLY, THE STEENSMA LAB STUDIED KINASE ENZYME INHIBITION IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS USING CAPMATINIB, TRAMETINIB, OR DOXORUBICIN TREATMENT. THEY FOUND BROAD AND REDUNDANT KINOME ADAPTATIONS, SHOWING THAT THESE TUMORS ARE CAPABLE OF PROFOUND SIGNALING PLASTICITY IN THE FACE OF SUCH TREATMENTS. SOME OF THE DATA SUGGEST THAT TARGETING AXL OR MFKB MAY LESSEN THE RESISTANCE TO THESE THERAPIES (GRIT ET AL., GENES 11(3): 331).
FORM 990, PART III, LINE 4B LINE 4B - PROGRAM SERVICE ACTIVITY #2 CENTER FOR EPIGENETICS THE CENTER, ESTABLISHED IN 2014 AND NOW DIRECTED BY J. ANDREW POSPISILIK, PH.D., HAS 10 LABORATORIES STUDYING EPIGENETICS, EPIGENOMICS, AND THE ROLE OF EPIGENETIC DYSFUNCTION IN CANCER, NEURODEGENERATIVE DISEASE, CARDIOVASCULAR DISEASE, AND VIRAL TRANSCRIPTION. NEW GRANT AWARDS IN THIS FISCAL YEAR FOR CENTER RESEARCHERS AND TRAINEES INCLUDED AN R01 AND AN R21 FROM THE NATIONAL INSTITUTES OF HEALTH, AS WELL AS AN NIH GRANT SUB-AWARD. THE LAB OF PETER JONES CONDUCTED A STUDY OF THE WHOLE-GENOME SEQUENCES OF 53 ORGANISMS, AND THEY SHOWED A POSITIVE CORRELATION BETWEEN THE SIZE OF A GENOME AND THE PERCENTAGE OF TRANSPOSABLE ELEMENTS (TES) IT CONTAINS. THE METHYLATION OF THE DNA OF SUCH ELEMENTS ALLOWS FOR THEIR LONG-TERM RESIDENCE IN THE GENOME, AND THEIR ACCUMULATION LEADS TO AN INCREASE IN GENOME SIZE. IT ALSO LEADS TO NEW OPPORTUNITIES FOR GENE CONTROL BY TE-BASED REGULATORY SITES (ZHOU ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA 117(32): 19359-19366). ANOTHER PROJECT LOOKED AT THE USE OF DNA METHYLTRANSFERASE INHIBITORS AS DRUGS FOR TREATING HEMATOLOGIC CANCERS. IN RESPONSE TO THIS TREATMENT, MALIGNANT CELLS SHOWED THE ACTIVATION OF NEWER TRANSPOSABLE ELEMENTS OF SEVERAL KINDS, AND CELL CULTURES SHOWED THE ACTIVATION OF SIX GENES IN THE TYPE I IFN PATHWAY. THUS, THE TES ELICITED AN IMMUNE REACTION THAT MAY BE IMPORTANT IN THE PATIENT'S RESPONSE TO THERAPY (OHTANI ET AL., CANCER RESEARCH 80(12): 2441-2450). THE ROTHBART LAB'S RESEARCH INVOLVES THE GAIN AND LOSS OF METHYL GROUPS ADDED TO DNA AND THE FUNCTION OF THOSE CHANGES. THE LIGASE UHRF1 IS KNOWN TO HELP MAINTAIN ABNORMAL DNA METHYLATION IN CANCER CELLS. THE LAB INVESTIGATED THIS ENZYME'S ACTIVITY AND THE PATTERN OF DNA METHYL GROUPS IN A VARIETY OF EXPERIMENTS, WHICH SHOWED THAT UHRF1 SELECTIVELY IDENTIFIES SPECIFIC METHYLATION POSITIONS ON BOTH DNA AND HISTONE PROTEINS. THEY ALSO FOUND THAT THE READER ACTIVITY OF THE UHRF1 TANDEM TUDOR DOMAIN IS DISPENSABLE FOR MAINTAINING DNA METHYLATION IN CANCER CELLS (VAUGHAN ET AL., EPIGENETICS AND CHROMATIN 13: 44). THE LAB HAS DEVELOPED A HIGH-THROUGHPUT BINDING ASSAY TO SHOW THE SEQUENCE DETERMINANTS OF METHYLLYSINE-DRIVEN PROTEIN INTERACTIONS. THEY ALSO USED IT TO IDENTIFY THE BINDING LOCALES OF HISTONE ANTIBODIES AND FOUND THAT ONLY A FEW AMINO ACIDS DRIVE EPITOPE RECOGNITION. THIS ASSAY WILL BE A VALUABLE RESOURCE FOR FUTURE STUDIES OF METHYLLYSINE-DRIVEN PROTEIN INTERACTIONS (KUPAI ET AL., FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8: 241). IN A THIRD PAPER, THE LAB DESCRIBED A NEW MODEL DEFINING CHROMATIN IMMUNOPRECIPITATION (CHIP-SEQ) TECHNOLOGY, AND THEY EXPLORED THE MODEL'S IMPLICATIONS FOR THE USE OF EXOGENOUS ADDITIVES (SPIKE-INS) WITH CHIP-SEQ. THEY IDENTIFIED A NEW SENSITIVITY ISSUE THAT LIMITS THE UTILITY AND TRUSTWORTHINESS OF SPIKE-INS. THIS PROMISES TO BE A VALUABLE STEP IN IMPROVING THE WIDELY USED CHIP-SEQ TECHNOLOGY (DICKSON ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY 295(47): 15826-15837). FINALLY, THEY COLLABORATED IN A PROJECT LOOKING AT THE RAPID TRANSCRIPTION OF SELECT GENES IN RESPONSE TO CUES SUCH AS THE SENSING OF PATHOGENS BY MACROPHAGES. THE AUTHORS PROPOSE THAT FEATURES OF THE HISTONE H3.3 PROVIDE PREFERENTIAL ACCESS TO THE TRANSCRIPTIONAL MACHINERY, AND THAT DEDICATED MECHANISMS ENABLE RAPID TRANSCRIPTION INVOLVING H3.3, ITS PHOSPHORYLATION, AND BOTH THE RECRUITMENT AND EJECTION OF CHROMATIN REGULATORS (ARMACHE ET AL., NATURE 583(7818): 852-857). THE SHI LAB TOOK PART IN A STUDY REPORTING THAT WNT ACTIVATION STABILIZES THE EPIGENETIC REGULATOR PROTEIN KDM4C, WHICH PROMOTES TUMORIGENESIS AND AIDS THE SURVIVAL OF HUMAN GLIOBLASTOMA CELLS. WNT-KDM4C-BETA-CATENIN SIGNALING REPRESENTS A NEW MECHANISM FOR THE TRANSCRIPTION OF WNT TARGET GENES AND THE REGULATION OF TUMORIGENESIS, AND IT HAS IMPORTANT CLINICAL IMPLICATIONS FOR THIS CANCER (CHEN ET AL., CANCER RESEARCH 80(5): 1049-1063). A SECOND PAPER LOOKED AT THE HUMAN ENZYME HERC2, WHICH IS LINKED TO NEUROLOGICAL DISEASES AND CANCER. A DETAILED STRUCTURE OF THE ENZYME'S ZZ DOMAIN WAS SOLVED, SHOWING THE NEGATIVELY CHARGED SITE OF THAT DOMAIN HAS A CRUCIAL ROLE IN THE ENZYME'S INTERACTIONS. THE ZZ DOMAIN MAY PLAY A ROLE IN THE ASSOCIATION OF HERC2 WITH CHROMATIN (LIU ET AL., STRUCTURE 28(11): 1225-1330.E3). ANOTHER PAPER FROM THE LAB LOOKED INTO CHANGES FOUND IN AN AGGRESSIVE FORM OF ACUTE MYELOID LEUKEMIA. THE DATA SUPPORT A CRUCIAL ROLE OF THE FUSION PROTEIN NUP98-PHF23 IN DRIVING LEUKEMOGENESIS. THEY HIGHLIGHT A DIRECT CORRELATION BETWEEN LEUKEMIC TRANSFORMATION AND THE ABILITIES OF NUP98-PHD FINGER CHIMERAS TO ASSOCIATE WITH H3K4ME3 METHYLATION SITES ON CHROMATIN (ZHANG ET AL., NATURE COMMUNICATIONS 11: 3339). THESE STUDIES ALL ADD TO OUR KNOWLEDGE OF THE MOLECULAR BASIS OF CANCER. THE LAIRD LAB CONTRIBUTED TO A PHASE 1 TRIAL OF TRC102 IN COMBINATION WITH TEMOZOLOMIDE FOR PATIENTS WHO HAD REFRACTORY SOLID TUMORS. OF 52 PATIENTS, FOUR HAD PARTIAL RESPONSES AND 13 HAD A BEST RESPONSE OF STABLE DISEASE. THE COMBINATION TREATMENT IS ACTIVE, AND THE SIDE-EFFECT PROFILE IS MANAGEABLE (COYNE ET AL., ONCOTARGET 11(44): 3959-3971). ANOTHER PAPER STUDIED TEN ESTIMATION METHODS FOR TUMOR PURITY IN A COHORT OF 333 PROSTATE CANCER PATIENTS. THE DATA SHOWED POOR CONCORDANCE BETWEEN PATHOLOGIC AND MOLECULAR PURITY ESTIMATES. THUS, THE CHOICE OF TUMOR PURITY ESTIMATION METHOD MAY HAVE A PROFOUND IMPACT ON THE INTERPRETATION OF GENOMIC ASSAYS, HIGHLIGHTING A NEED FOR IMPROVED WAYS TO ASSESS TUMOR PURITY (HAIDER ET AL., JCO PRECISION ONCOLOGY 4: 995-1005). THE SHEN LAB TOOK PART IN A PHASE II CLINICAL TRIAL OF METFORMIN AGAINST EPITHELIAL OVARIAN CANCER. METFORMIN WAS WELL TOLERATED, AND TREATED TUMORS SHOWED INCREASED SENSITIVITY TO CISPLATIN EX VIVO. IT ALTERED THE METHYLATION SIGNATURE OF CARCINOMA-ASSOCIATED MESENCHYMAL STEM CELLS, PREVENTING CHEMORESISTANCE IN VITRO. THE STUDY SUPPORTS THE USE OF METFORMIN IN PHASE II STUDIES (BROWN ET AL., JCI INSIGHT 5(11): E1332247). THE SHEN AND TRICHE LABS BOTH CONTRIBUTED TO A STUDY OF UTERINE FIBROIDS. SIGNIFICANT OVERLAP OF DIFFERENTIALLY EXPRESSED GENES WAS OBSERVED FOR CERVICAL STROMA OR UTERINE FIBROIDS COMPARED WITH NORMAL MYOMETRIUM. THESE ANALYSES SHOW A POSSIBLE ROLE OF DNA METHYLATION IN FIBROID BIOLOGY, AND THEY SUGGEST THAT HOMEOTIC TRANSFORMATION OF MYOMETRIAL CELLS TO A MORE CERVICAL STROMA PHENOTYPE COULD BE AN IMPORTANT MECHANISM IN THE DISEASE (GEORGE ET AL., CELL REPORTS 29(12): 4069-4085.E6). STEFAN JOVINGE'S LAB HELPED EVALUATE THE EFFECT OF S100A9 BLOCKADE ON POST-ISCHEMIC CARDIAC REPAIR. SEVEN DAYS OF TREATMENT WERE BENEFICIAL, BUT 21 DAYS OF BLOCKADE LED TO DETERIORATION OF CARDIAC FUNCTION IN MICE. THUS, THERE IS A THERAPEUTIC WINDOW FOR OPTIMAL EFFECT OF THIS TREATMENT IN ACUTE MYOCARDIAL INFARCTION (MARINKOVIC ET AL., CIRCULATION RESEARCH 127(5): 664-676). IN ANOTHER STUDY, THE LAB COLLABORATED IN A STUDY OF THE CO-CULTURE OF CARDIOMYOCYTES AND SYMPATHETIC NEURONS, BOTH DERIVED FROM HUMAN-INDUCED PLURIPOTENT STEM CELLS. THE DATA SHOWED THE DEVELOPMENT OF ELECTROPHYSIOLOGICALLY FUNCTIONAL SYMPATHETIC NEURONS THAT ARE CAPABLE OF MODULATING THE BEATING RATE OF THE CARDIOMYOCYTES IN VITRO. THESE HUMAN CELL CO-CULTURES PROVIDE A NOVEL MULTICELLULAR MODEL FOR THE STUDY OF NEUROCARDIAC MODULATION UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS (WINBO ET AL., AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 319(5): H927-H937). THE POSPISILIK LAB COAUTHORED A PAPER SHOWING THAT MACROPHAGES CAN MAINTAIN INSULIN SECRETION IN VIVO FOLLOWING BETA-CELL DEATH, WITH NO EFFECTS ON ISLET CELL TURNOVER. IGF-1 NEUTRALIZATION DURING STREPTOZOTOCIN TREATMENT DECREASED INSULIN SECRETION WITHOUT AFFECTING ISLET CELL APOPTOSIS OR PROLIFERATION. A HIGH-FAT DIET PLUS STZ FURTHER SKEWED ISLET MACROPHAGES TO A REPARATIVE STATE (NACKIEWICZ ET AL., ISCIENCE 23(1): 100775). THE LAB ALSO COLLABORATED IN RESEARCH INTO ADHESION G-PROTEIN-COUPLED RECEPTORS IN ADIPOSE TISSUE. THE PROJECT CONCLUDED THAT ADHESION GPCRS ARE SIGNIFICANTLY INVOLVED IN QUALITATIVE AND QUANTITATIVE LIPID ACCUMULATION IN ADIPOCYTES AND CAN CONTROL LIPOLYSIS. FACTORS DRIVING ADIPOCYTE FORMATION AND FUNCTION ARE GOVERNED BY SIGNALING PATHWAYS INDUCED BY ADHESION GPCRS, SUGGESTING THAT THESE RECEPTORS ARE POTENTIAL TARGETS FOR TREATING OBESITY (SUCHY ET AL., INTERNATIONAL JOURNAL OF OBESITY 44(10): 2124-2136).
FORM 990, PART III, LINE 4C LINE 4C - PROGRAM SERVICE ACTIVITY #3 CENTER FOR NEURODEGENERATIVE SCIENCE THE CENTER WAS ESTABLISHED IN 2012 UNDER DIRECTOR PATRIK BRUNDIN, M.D., PH.D. IN 2020, IT HAD NINE LABORATORIES STUDYING PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, AND THE RELATIONSHIPS BETWEEN DEPRESSION, SUICIDE, AND BRAIN INFLAMMATION. THE NEWEST LABORATORY, THAT OF MICHAEL HENDERSON, PH.D., FOCUSES ON THE PATHOGENESIS AND POTENTIAL THERAPIES FOR PARKINSON'S DISEASE AND DEMENTIA WITH LEWY BODIES. CENTER RESEARCHERS AND TRAINEES DURING THIS FISCAL YEAR RECEIVED FIVE R01S AND AN R21 FROM THE NATIONAL INSTITUTES OF HEALTH, TWO AWARDS FROM THE MICHAEL J. FOX FOUNDATION AND THREE FROM THE ASAP COLLABORATIVE RESEARCH NETWORK, AND A SUBAWARD FROM THE PARKINSON'S FOUNDATION. A POSTDOCTORAL FELLOWSHIP WAS ALSO RECEIVED FROM THE PARKINSON'S FOUNDATION. THE LENA BRUNDIN LAB EXPLORED THE INCREASED INFLAMMATION REPORTED IN MAJOR DEPRESSIVE DISORDER (MDD), WHICH MAY BE DRIVEN BY VITAMIN D DEFICIENCY. WHILE 25(OH)D LEVELS DID NOT SIGNIFICANTLY DIFFER IN MDD VS. CONTROLS, LOWER 25(OH)D WAS ASSOCIATED WITH INDICES OF IMMUNE ACTIVATION IN MDD, ESPECIALLY IN CASES WITH SUICIDAL IDEATION. THE FINDINGS ARE CONSISTENT WITH RELATIVELY LOW 25(OH)D LEVELS IN MDD BEING ASSOCIATED WITH A PRO-INFLAMMATORY STATE (GRUDET ET AL., JOURNAL OF AFFECTIVE DISORDERS 267: 33-41). ANOTHER STUDY FOCUSED ON TRYPTOPHAN (TRP) METABOLITES IN THE CEREBROSPINAL FLUID (CSF), WHICH MAY BE MODULATORS OF PSYCHIATRIC DISEASE. THE LAB SHOWED THE FEASIBILITY OF BIOCHEMICAL ANALYSIS OF CSF TRP METABOLITES, INCLUDING THE SEPARATION OF PICOLINIC ACID FROM NICOTINIC ACID. THEY ALSO CONFIRMED PRIOR FINDINGS OF ABERRANT CSF QUINOLINIC ACID AND PICOLINIC ACID IN SUICIDE ATTEMPTERS (SCHWIELER ET AL., BIOANALYSIS 12(6): 379-392). THE LABS OF PATRIK AND LENA BRUNDIN COLLABORATED IN LOOKING AT TRYPTOPHAN METABOLITES IN PARKINSON'S DISEASE PATIENTS. PD SUBJECTS HAD OVER 100% HIGHER 3-HYDROXYKYNURENINE AND 14% LOWER 3-HYDROXYANTHRANILIC ACID CONCENTRATIONS IN THEIR PLASMA. OVERALL, KYNURENINE PATHWAY METABOLITES WERE ALTERED IN PD PATIENTS IN BOTH THE PERIPHERY AND THE CENTRAL NERVOUS SYSTEM, AND THESE CHANGES ASSOCIATED WITH SYMPTOM SEVERITY (HEILMAN ET AL., MOVEMENT DISORDERS 35(11): 2028-2037). THE PATRIK BRUNDIN LAB EVALUATED THE SMELLING FUNCTION OF MICE AFTER INJECTING ALPHA-SYNUCLEIN PREFORMED FIBRILS INTO THE OLFACTORY BULB. NO OVERT IMPAIRMENTS IN SNIFFING ABILITY WERE EVIDENT. AT ALL TIME POINTS, FEMALES HAD A REDUCED ABILITY TO DETECT ODORS IN A PLETHYSMOGRAPHY TEST. THIS SENSITIVE METHOD COULD BE USED TO DEFINE HOW ALPHA-SYNUCLEIN PATHOLOGY AFFECTS OTHER ASPECTS OF OLFACTORY PERCEPTION AND TO CLARIFY THE NEUROPATHOLOGICAL BASIS OF THESE DEFICITS (JOHNSON ET AL., SCIENTIFIC REPORTS 10(1): 9242). A SECOND SET OF EXPERIMENTS FOUND PATHOLOGY IN BOTH THE OLFACTORY BULB AND THE PIRIFORM CORTEX OF MICE INJECTED WITH ALPHA-SYNUCLEIN FIBRILS. THE MICE DISPLAYED ABERRANTLY HIGH ODOR-EVOKED POWER IN THE BETA SPECTRAL RANGE. NO SIMILAR CHANGE WAS FOUND IN THE PIRIFORM CORTEX, DESPITE HIGH LEVELS OF PATHOLOGY. THESE RESULTS PROVIDE EVIDENCE THAT SYNUCLEINOPATHY AFFECTS NEURAL ACTIVITY IN THE OLFACTORY SYSTEM AT THE NETWORK LEVEL (KULKARNI ET AL., JOURNAL OF PARKINSON'S DISEASE 10(4): 1411-1427). A THIRD PAPER REPORTED THE INJECTION OF FIVE CONFORMATIONAL STRAINS OF ALPHA-SYNUCLEIN INTO THE OLFACTORY BULB OF FEMALE MICE. EACH STRAIN PROPAGATED PATHOLOGY THROUGH THE CENTRAL NERVOUS IN DISTINCT PATTERNS. THE DATA SUPPORT THE VIEW THAT THE CONFORMATIONS OF ALPHA-SYNUCLEIN ASSEMBLIES MAY UNDERLIE DIFFERENT PROPAGATION PATTERNS WITHIN THE HUMAN BRAIN (REY ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS 7:221). THE MOORE LAB STUDIED THE LRRK2 KINASE ENZYME AND IDENTIFIED ITS FUNCTION IN REGULATING MEMBRANE FUSION AT THE TRANS-GOLGI NETWORK, INFLUENCING BOTH RETROGRADE AND POST-GOLGI TRAFFICKING PATHWAYS. ITS ACTION IS EXAGGERATED BY MUTATIONS ASSOCIATED WITH PARKINSON'S DISEASE AND CAN BE BLOCKED BY KINASE INHIBITORS. DISRUPTION OF THE GARP PROTEIN COMPLEX SENSITIZES DOPAMINERGIC NEURONS TO MUTANT LRRK2 TOXICITY IN C. ELEGANS, SHOWING THAT THESE PATHWAYS ARE INTERLINKED IN VIVO AND SUGGESTING A LINK IN PD (BEILINA ET AL., CELL REPORTS 31(5): 107614). THE LAB ALSO DEVELOPED A ROBUST PRECLINICAL MODEL OF PARKINSON'S DISEASE IN ADULT RATS HAVING NEURON-SPECIFIC EXPRESSION OF HUMAN LRRK2 BEARING THE G2019S MUTATION, WHICH INDUCES ROBUST DEGENERATION OF SUBSTANTIA NIGRA DOPAMINERGIC NEURONS. THIS MODEL SHOWED THAT SUCH NEURODEGENERATION REQUIRES NORMAL GTPASE AND KINASE ACTIVITY. INHIBITION OF THE KINASE AND ALTERATION OF GTPASE ACTIVITY MAY BE PROMISING AS DISEASE-MODIFYING TARGETS (NGUYEN ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA 117(29): 17296-17307). THE LAB ALSO PUBLISHED TWO REVIEWS, ONE ON THE FUNCTIONS OF LRRK2 WITH THE ENDOLYSOSOMAL PATHWAY (ERB AND MOORE, JOURNAL OF PARKINSON'S DISEASE 10(4): 1271-1291) AND ANOTHER ON THE LINKAGE BETWEEN LRRK2 AND PROTEIN AGGREGATION IN ANIMAL MODELS OF PARKINSON'S DISEASE (DUES AND MOORE, FRONTIERS IN NEUROSCIENCE 14:719). THE GUERREIRO AND BRAS LABS COLLABORATED ON PROJECTS IN SEVERAL DIVERSE AREAS. THE KCNN2 GENE IS HIGHLY EXPRESSED IN THE HUMAN BRAIN. ONE OF THEIR PAPERS REPORTED A MISSENSE MUTATION IN THAT GENE WHICH TRACKED WITH THE CHILDHOOD-ONSET TREMORS CHARACTERISTIC OF MYOCLONUS-DYSTONIA. THIS IS THE FIRST SUGGESTION THAT KCNN2 MUTATIONS COULD BE A PLAUSIBLE CAUSE OF THIS DISEASE (BALINT ET AL., EUROPEAN JOURNAL OF NEUROLOGY 27(8): 1471-1477). THE LABS ALSO PUBLISHED THE RESULTS OF WHOLE-EXOME SEQUENCING OF A COHORT OF 1118 CAUCASIAN PATIENTS WHO HAD DEMENTIA WITH LEWY BODIES (DLB); THEY FOCUSED ON GENES THAT CAUSE MONOGENIC NEURODEGENERATIVE DISEASES. THE RARITY OF PREVIOUSLY REPORTED PATHOGENIC MUTATIONS IN THIS COHORT SUGGESTS THAT THE GENETIC OVERLAP BETWEEN OTHER NEURODEGENERATIVE DISEASES AND DLB IS NOT SUBSTANTIAL (ORME ET AL. ACTA NEUROPATHOLOGICA COMMUNICATIONS 8(1): 5). A THIRD PAPER IDENTIFIED A NOVEL HOMOZYGOUS MISSENSE MUTATION OF THE MYELIN-ASSOCIATED GLYCOPROTEIN (MAG) IN A PORTUGUESE FAMILY WITH EARLY-ONSET, AUTOSOMAL RECESSIVE, CEREBELLAR ATAXIA WITH NEUROPATHY AND OCULOMOTOR APRAXIA. THE MUTATION REDUCED PROTEIN STABILITY, IMPAIRED THE PROTEIN'S GLYCOSYLATION, AND CHANGED ITS SUBCELLULAR LOCATION. THIS MUTATION THUS PROVIDES A NEW DIAGNOSTIC MARKER FOR HEREDITARY OCCURRENCES OF THIS DISEASE (SANTOS ET AL., JOURNAL OF CLINICAL MEDICINE 9(4): 1212). THEY ALSO WORKED ON A STUDY OF GENETIC FRONTOTEMPORAL DEMENTIA, USING AN INTERNATIONAL, RETROSPECTIVE COHORT OF 3403 INDIVIDUALS FROM 1492 FAMILIES. IT SHOWED THAT THE AGE AT SYMPTOM ONSET AND AT DEATH OF PATIENTS IS INFLUENCED BY THEIR GENETIC GROUP, BY THE SPECIFIC MUTATION CARRIED, AND BY FAMILY MEMBERSHIP. THE DATA SUGGEST THAT STUDYING OTHER MEMBERS OF A FAMILY WILL BE HELPFUL ONLY FOR INDIVIDUALS WITH MUTATIONS OF THE MAPT GENE. (MOORE ET AL., LANCET NEUROLOGY 19(2): 145-156). THE LABRIE LAB REPORTED THAT NEURONS IN THE HUMAN PREFRONTAL CORTEX HAVE HEMISPHERIC DIFFERENCES IN DNA METHYLATION LARGELY MEDIATED BY DIFFERENTIAL CPH METHYLATION. THE ASYMMETRY IS GREATER IN NEURONS OF PARKINSON'S DISEASE PATIENTS THAN IN HEALTHY CONTROLS. THESE DIFFERENCES MAY AFFECT THE PROGRESSION AND SYMPTOMS OF PARKINSON'S DISEASE (LI ET AL., GENOME BIOLOGY 21: 61). IN ANOTHER PAPER, THE LABRIE, COETZEE, AND JOVINGE LABS FOUND A WIDESPREAD INCREASE IN CYTOSINE METHYLATION AT THE ENHANCER LOCI IN PARKINSON'S DISEASE NEURONS. PARKINSON'S PATIENTS SHOWED AN INCREASE IN TET2 GENE ACTIVITY, WHICH IS A MASTER REGULATOR OF CYTOSINE MODIFICATIONS. DECREASED TET2 ACTIVITY IS NEUROPROTECTIVE IN MICE AND MAY BE A NEW THERAPEUTIC AVENUE AGAINST PARKINSON'S DISEASE (WEILAND ET AL., NATURE NEUROSCIENCE 23(10): 1203-1214).
FORM 990, PART IX, COLUMN D FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH DONOR SOLICITATION, GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION.
FORM 990, PART X, LINE 33 VARI NET ASSETS ARE CONSIDERED ON A CONSOLIDATED BASIS WITH VAN ANDEL INSTITUTE (VAI)AND VAN ANDEL EDUCATION INSTITUTE (VAEI). ON A CONSOLIDATED BASIS, NET ASSETS ARE $1,635,281,000 PER AUDITED FINANCIAL STATEMENTS. THE NEGATIVE NET ASSET BALANCE AT VARI IS DUE TO VAI FUNDING EXPENSES ON A CASH BASIS AND THE UNREALIZED LOSS RECORDED IN ASSOCIATION WITH THE INTEREST RATE SWAP.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2019


Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)

Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBulletAttach to Form 990.
MediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047
2019
Open to Public Inspection
Name of the organization
VAN ANDEL RESEARCH INSTITUTE
 
Employer identification number

52-2000823
Part I
Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


(c)
Legal domicile (state
or foreign country)

(d)
Total income


(e)
End-of-year assets


(f)
Direct controlling
entity

(1) VAI INNOVATIONS LLC
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
52-2000823
LICENSING INTELLECTUAL PROPERTY OF VARI MI 144,192 0 VAN ANDEL RESEARCH INSTITUTE
 
(2) BOSTWICK EVENT MANAGEMENT
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
52-2000823
EVENT MANAGEMENT MI 5,426 118,506 VAN ANDEL RESEARCH INSTITUTE
 
(3) C3 LEARNING DEVELOPMENT LLC
333 BOSTWICK AVENUE NE
GRAND RAPIDS,MI495032518
52-2000823
EDUCATIONAL PROGRAMS FOR K-12 STUDENTS AND TEACHERS MI 72,102 372,540 VAN ANDEL RESEARCH INSTITUTE
 






Part II
Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.
(a)
Name, address, and EIN of related organization


(b)
Primary activity


(c)
Legal domicile (state
or foreign country)

(d)
Exempt Code section


(e)
Public charity status
(if section 501(c)(3))

(f)
Direct controlling
entity

(g)
Section 512(b)(13) controlled entity?
Yes No
(1)VAN ANDEL INSTITUTE
333 BOSTWICK AVENUE NE

GRAND RAPIDS,MI495032518
52-2000820
SUPPORTING ORGANIZATION FOR VARI AND VAEI MI 501(C)(3) 12C N/A
 
No
(2)VAN ANDEL EDUCATION INSTITUTE
333 BOSTWICK AVENUE NE

GRAND RAPIDS,MI495032518
52-2000824
OPERATING A SCIENCE EDUCATION PROGRAM MI 501(C)(3) 2 VAN ANDEL INSTITUTE
 
Yes
 
(3)VAN ANDEL INSTITUTE GRADUATE SCHOOL
333 BOSTWICK AVENUE NE

GRAND RAPIDS,ME495032518
20-3340886
OPERATING A GRADUATE SCHOOL MI 501(C)(3) 2 VAN ANDEL EDUCATION INSTITUTE
 
Yes
 








For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2019
Schedule R (Form 990) 2019
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related organizations treated as a partnership during the tax year.
(a)
Name, address, and EIN of
related organization



(b)
Primary activity




(c)
Legal
domicile
(state or foreign
country)


(d)
Direct controlling
entity



(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




(g)
Share of end-of-year
assets



(h)
Disproprtionate allocations?




(i)
Code V-UBI
amount in box 20 of
Schedule K-1
(Form 1065)
(j)
General or
managing
partner?



(k)
Percentage
ownership


Yes No Yes No












Part IV
Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.
(a)
Name, address, and EIN of
related organization
(b)
Primary activity
(c)
Legal
domicile
(state or foreign
country)
(d)
Direct controlling
entity
(e)
Type of entity
(C corp, S corp,
or trust)
(f)
Share of total income
(g)
Share of end-of-year
assets
(h)
Percentage
ownership
(i)
Section 512(b)(13) controlled entity?
Yes No












Schedule R (Form 990) 2019
Schedule R (Form 990) 2019
Page 3
Part V
Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................
1a
 
No
b Gift, grant, or capital contribution to related organization(s) ............................
1b
 
No
c Gift, grant, or capital contribution from related organization(s) ............................
1c
Yes
 
d Loans or loan guarantees to or for related organization(s) ............................
1d
 
No
e Loans or loan guarantees by related organization(s) ............................
1e
Yes
 
f Dividends from related organization(s) ............................
1f
 
No
g Sale of assets to related organization(s) ............................
1g
 
No
h Purchase of assets from related organization(s) ............................
1h
 
No
i Exchange of assets with related organization(s) ............................
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) .......................
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) ......................
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) .....................
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) .................
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................
1n
Yes
 
o Sharing of paid employees with related organization(s) ............................
1o
Yes
 
p Reimbursement paid to related organization(s) for expenses ............................
1p
Yes
 
q Reimbursement paid by related organization(s) for expenses ............................
1q
Yes
 
r Other transfer of cash or property to related organization(s) ............................
1r
 
No
s Other transfer of cash or property from related organization(s) ............................
1s
Yes
 
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of related organization
(b)
Transaction
type (a-s)
(c)
Amount involved
(d)
Method of determining amount involved
(1) VAN ANDEL INSTITUTE

C 54,223,134 ACTUAL AMOUNT PAID
(2) VAN ANDEL INSTITUTE

E 99,600,000 TOTAL RECORDED
(3) VAN ANDEL INSTITUTE

N 283,368 ALLOCATION BASED ON SQ. FOOTAGE
(4) VAN ANDEL INSTITUTE

P 1,186,444 ACTUAL AMOUNT PAID
(5) VAN ANDEL INSTITUTE

N 130,544 ALLOCATION BASED ON EFFORT
(6) VAN ANDEL INSTITUTE

O 1,092,310 ALLOCATION BASED ON EFFORT
(7) VAN ANDEL EDUCATION INSTITUTE

P 1,774,390 ACTUAL AMOUNT PAID
(8) VAN ANDEL EDUCATION INSTITUTE

Q 2,360,200 ACTUAL AMOUNT RECEIVED
(9) VAN ANDEL EDUCATION INSTITUTE

N 32,941 ALLOCATION BASED ON EFFORT
(10) VAN ANDEL EDUCATION INSTITUTE

O 275,630 ALLOCATION BASED ON EFFORT
(11) VAN ANDEL INSTITUTE GRADUATE SCHOOL

N 3,965 ALLOCATION BASED ON EFFORT
(12) VAN ANDEL INSTITUTE GRADUATE SCHOOL

N 159,394 ALLOCATION BASED ON SQ. FOOTAGE
(13) VAN ANDEL INSTITUTE GRADUATE SCHOOL

Q 305,904 ACTUAL AMOUNT RECEIVED
(14) VAN ANDEL INSTITUTE GRADUATE SCHOOL

O 33,178 ALLOCATION BASED ON EFFORT
(15) VAN ANDEL INSTITUTE

Q 6,975,460 ACTUAL AMOUNT RECEIVED
(16) VAN ANDEL INSTITUTE GRADUATE SCHOOL

P 222,083 ACTUAL AMOUNT PAID
(17) VAN ANDEL INSTITUTE GRADUATE SCHOOL

O 188,875 ALLOCATION BASED ON EFFORT
(18) VAN ANDEL EDUCATION INSTITUTE

O 17,664 ALLOCATION BASED ON EFFORT
(19) VAN ANDEL INSTITUTE

O 85,772 ALLOCATION BASED ON EFFORT
(20) VAN ANDEL EDUCATION INSTITUTE

S 213,714 NET ASSETS RECEIVED
Schedule R (Form 990) 2019
Schedule R (Form 990) 2019
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity
(b)
Primary activity
(c)
Legal domicile
(state or foreign
country)
(d)
Predominant income (related, unrelated, excluded from tax under sections 512-514)

(e)
Are all partners
section
501(c)(3)
organizations?
(f)
Share of total income




(g)
Share of
end-of-year
assets
(h)
Disproprtionate allocations?
(i)
Code V-UBI
amount in box 20
of Schedule K-1
(Form 1065)
(j)
General or
managing
partner?
(k)
Percentage
ownership


Yes No Yes No Yes No






























Schedule R (Form 990) 2019
Schedule R (Form 990) 2019
Page 5
Part VII
Supplemental Information
Provide additional information for responses to questions on Schedule R. (see instructions).
Return Reference Explanation
SCHEDULE R, PART V, LINE 2 (20) THIS AMOUNT REPRESENTS NET ASSETS OF $213,714 TRANSFERRED FROM VAN ANDEL EDUCATION INSTITUTE FOR C3 LEARNING DEVELOPMENT, LLC.
Schedule R (Form 990) 2019

Additional Data


Software ID:  
Software Version: