Form990
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Department of the TreasuryInternal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)
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OMB No. 1545-0047
2020
Open to Public Inspection
A For the 2020 calendar year, or tax year beginning 01-01-2020 , and ending 12-31-2020
BCheck if applicable:
CName of organization
J CRAIG VENTER INSTITUTE
 
 
Doing business as
 
 
Number and street (or P.O. box if mail is not delivered to street address)
4120 CAPRICORN LANE
 
Room/suite
City or town, state or province, country, and ZIP or foreign postal code
LA JOLLA, CA92037
D Employer identification number

52-1842938
E Telephone number

G Gross receipts $ 28,482,912
F Name and address of principal officer:
JOHN CRAIG VENTER
4120 CAPRICORN LANE
LA JOLLA,CA92037
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
WWW.JCVI.ORG
H(a)
Is this a group return for
subordinates?
H(b)
Are all subordinates
included?
If "No," attach a list. (see instructions)
H(c)
Group exemption number MediumBullet  
K Form of organization:  
L Year of formation: 1993
M State of legal domicile: MD
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: JCVI IS ADVANCING THE SCIENCE OF GENOMICS THROUGH BOLD INNOVATIONS. OUR MISSION IS TO UNDERSTAND MOREABOUT THE BIOLOGICAL WORLD, AND TO DEVELOP UNIQUE INSIGHTS AND ANSWERSABOUT DISEASE, HEALTH, AND THE ENVIRONMENT FOR THE BENEFIT OF ALL.
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 8
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 5
5 Total number of individuals employed in calendar year 2020 (Part V, line 2a) ...... 5 180
6 Total number of volunteers (estimate if necessary) ............. 6 7
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 15,294
b Net unrelated business taxable income from Form 990-T, line 39 ......... 7b 0
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 21,442,951 18,613,419
9 Program service revenue (Part VIII, line 2g) ......... 420,120 123,655
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 1,920,374 -823,759
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 6,009 15,294
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12) 23,789,454 17,928,609
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 2,586,471 2,842,807
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 21,730,028 19,124,778
16a Professional fundraising fees (Part IX, column (A), line 11e) ..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet686,812    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 13,109,263 8,407,194
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 37,425,762 30,374,779
19 Revenue less expenses. Subtract line 18 from line 12....... -13,636,308 -12,446,170
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 108,987,608 100,269,815
21 Total liabilities (Part X, line 26)............. 35,167,258 36,854,821
22 Net assets or fund balances. Subtract line 21 from line 20..... 73,820,350 63,414,994
Part II
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Cat. No. 11282Y Form 990 (2020)
Form 990 (2020)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III..............
1
Briefly describe the organization’s mission: JCVI IS ADVANCING THE SCIENCE OF GENOMICS THROUGH BOLD INNOVATIONS. OUR MISSION IS TO UNDERSTAND MORE ABOUT THE BIOLOGICAL WORLD, AND TO DEVELOP UNIQUE INSIGHTS AND ANSWERS ABOUT DISEASE, HEALTH, AND THE ENVIRONMENT FOR THE BENEFIT OF ALL.
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? .....................
If "Yes," describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ...........................
If "Yes," describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 7,864,788 including grants of $ 2,782,839 ) (Revenue $ 123,655 )
THROUGHOUT THE FISCAL YEAR 2020, THE JCVI RECEIVED FUNDING FROM VARIOUS FEDERAL AND NON-FEDERAL SPONSORING AGENCIES AND FOUNDATIONS SUPPORTING IN EXCESS OF 85 ACTIVE RESEARCH PROJECTS COVERING A RANGE OF RESEARCH AREAS INCLUDING HUMAN HEALTH, ENVIRONMENTAL SUSTAINABILITY, SYNTHETIC BIOLOGY, TECHNOLOGY AND TOOLS, EDUCATION AND POLICY. DEPARTMENT OF HEALTH AND HUMAN SERVICES (DHHS) -FUNDED BY THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID/NIH) AND IN COLLABORATION WITH THE UNIVERSITY OF CHICAGO, THE JCVI SERVES AS THE MAIN DEVELOPER OF THE VIRAL PATHOGEN RESOURCE (WWW.VIPRBRC.ORG) AND THE INFLUENZA RESEARCH DATABASE (WWW.FLUDB.ORG). THESE RESOURCES SERVE AS FREE PUBLIC PORTALS TO A WIDE RANGE OF INFORMATION, DATA, AND ANALYTICAL TOOLS FOR INTERPRETING VIRAL GENOMES IN THE CONTEXT OF DISEASE. OVER 3000 RESEARCHERS THROUGHOUT THE WORLD USE THESE RESOURCES EVERY WEEK. JCVI CONTINUED TO LEAD A 5-YEAR COLLABORATIVE NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS/NIH) GRANT WITH THE GOAL TO DEVELOP, VALIDATE AND DISSEMINATE A COMPUTATIONAL INFRASTRUCTURE FOR UNBIASED ANALYSIS OF CYTOMETRY DATA FOR BOTH DIAGNOSTIC AND DISCOVERY APPLICATIONS THAT COULD HELP OVERCOME THE CURRENT LIMITATIONS OF MANUAL ANALYSIS AND PROVIDE FOR MORE EFFICIENT, OBJECTIVE, ACCURATE, AND REPRODUCIBLE ANALYSIS OF CYTOMETRY DATA. FLOW CYTOMETRY ANALYSIS IS WIDELY USED IN TRANSLATIONAL RESEARCH LAB TO EXPLORE THE MECHANISMS OF NORMAL AND ABNORMAL BIOLOGICAL PROCESSES AND IN THE CLINICAL DIAGNOSTIC LAB FOR THE IDENTIFICATION AND CLASSIFICATION OF BLOOD-BORNE MALIGNANCIES. HOWEVER, THE CURRENT PRACTICE FOR CYTOMETRY DATA ANALYSIS RELIES ON SUBJECTIVE AND AD HOC "MANUAL GATING". THE PROJECT TEAM OF JCVI, THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (UCSD), THE UNIVERSITY OF CALIFORNIA, IRVINE (UCI), AND STANFORD UNIVERSITY COLLABORATED TO CONTINUE IMPROVING THE ACCESSIBILITY, FUNCTIONALITY, AND USABILITY OF THE PROPOSED INFRASTRUCTURE. THE PROJECT TEAMS ASSEMBLED MULTIPLE FLOW CYTOMETRY DATASETS FROM IMPORTANT BIOMEDICAL PROJECTS CONDUCTED BY TRANSLATIONAL RESEARCHERS AT UC IRVINE AND FROM THE CLINICAL DIAGNOSTICS LAB AT UCSD. THE JCVI TEAM PROCESSED AND ANALYZED THE DATASETS USING THE COMPUTATIONAL INFRASTRUCTURE AND VALIDATED THE ANALYSIS RESULTS USING FOLLOW-UP STUDIES. THE COMPUTATIONAL ANALYSES OF THESE DATASETS HAVE IDENTIFIED NOVEL CELL SUBSETS FROM HUMAN LEUKOCYTES FOR INDEPENDENT ASTHMA RESEARCH PROJECTS BEING CONDUCTED AT PEDIATRICS OF UC IRVINE. THE ANALYSES HAVE ALSO IDENTIFIED A NOVEL COMBINATION OF CELL SURFACE MARKERS FOR PRECISION DIAGNOSIS OF THE CHRONIC LYMPHOCYTIC LEUKEMIA BASED ON THE CLINICAL FLOW CYTOMETRY DATA PROVIDED BY UCSD. THE RESULTS AND FINDINGS HAVE BEEN PUBLISHED ON PEER-REVIEWED JOURNALS OR REPORTED AT SCIENTIFIC CONFERENCES. THE PROJECT TEAM HAVE ALSO BEEN TRAINING THE TRANSLATIONAL RESEARCHERS OF UCI PEDIATRICS AND HEMATOPATHOLOGISTS OF UCSD PATHOLOGY FOR USING THE ADVANCED DATA ANALYTICS TOOLS ON THE COMPUTATIONAL INFRASTRUCTURE THROUGH IN-PERSON SITE VISITS AND WEBEX MEETINGS. FUNDED THROUGH THE NATIONAL INSTITUTE OF ALLERGY AND IMMUNOLOGY (NIAID/NIH) AND IN COLLABORATION WITH NORTHEASTERN UNIVERSITY. ANTIBIOTIC RESISTANCE CONTINUES TO BE ONE OF THE BIGGEST PUBLIC HEALTH PROBLEMS OF OUR TIME. JCVI IN COLLABORATION WITH NORTHEASTERN UNIVERSITY HAVE DEVELOPED NEW METHODS TO GROW AND EXPLOIT PREVIOUSLY UNCHARACTERIZED MICROBES. JCVI DEVELOPED A TRANSCRIPTION-BASED PLATFORM THAT BIOINFORMATICALLY PREDICTS WHETHER NEW POTENTIAL COMPOUNDS ARE EXPRESSING ANTIBIOTIC PROPERTIES WITH NOVEL MECHANISMS OF ACTION. PROMISING COMPOUNDS ARE VALIDATED AND BECOME LEAD ANTIMICROBIAL COMPOUNDS FOR FURTHER STUDY. AS PART OF AN NIH GRANT IN COLLABORATION WITH COLLEAGUES AT UC IRVINE, THE RESEARCH TEAM HAVE BEEN APPLYING ADVANCE LABORATORY, COMPUTATIONAL, AND ARTIFICIAL INTELLIGENCE METHODS TO EXPLORE WHY SOME PEOPLE INFECTED WITH SARS-COV-2 DEVELOP SEVERE DISEASE WHILE OTHERS ARE ASYMPTOMATIC OR ONLY DEVELOP MILD SYMPTOMS. WE HAVE ALSO EXPLORED THE IMPACT THAT CORTICOSTEROID TREATMENT HAS ON COVID PATIENTS. WE FOUND THAT WHILE SEVERE COVID PATIENTS MOUNT AN EFFECTIVE ANTIBODY RESPONSE, THEY ALSO DEVELOP A MORE SEVERE GENERAL INFLAMMATORY REACTION, AND THAT THIS INFLAMMATORY RESPONSE WAS DAMPENED WITH STEROID TREATMENT. THESE FINDINGS SUGGEST THAT STEROID-BASED INTERVENTIONS COULD POTENTIAL LIMIT SEVERE COVID DISEASE AND WERE REPORTED IN A RECENT PUBLICATION IN THE JOURNAL OF LEUKOCYTE BIOLOGY (HTTPS://JLB.ONLINELIBRARY.WILEY.COM/DOI/EPDF/10.1002/JLB.4COVA0121-084RR). FUNDED BY NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS/NIH) MICROBIOME IN ASTHMA INDUCED BY ENVIRONMENTAL PARTICLE EXPOSURE. IN COLLABORATION WITH BROWN UNIVERSITY. MICROBIAL DYSBIOSIS IN THE GUT AND THE LUNG IS INCREASINGLY BEING ASSOCIATED WITH THE INCIDENCE AND SEVERITY OF ASTHMA, HOWEVER CAUSALITY STUDIES ARE LACKING. JCVI AND ITS COLLABORATOR, BROWN UNIVERSITY HAVE ADAPTED A MOUSE MODEL THAT FOCUSES ON THE ONSET OF ALLERGIC ASTHMA EARLY IN LIFE AFTER AN IN-UTERO EXPOSURE TO ENVIRONMENTAL PARTICLES TO STUDY HOW MICROBIOME MAY LEAD TO THE ASTHMA ONSET. IN THIS MODEL, THE RESEARCH TEAM HAS SHOWN THAT MATERNAL EXPOSURES TO ALLERGEN OR PARTICULATE MATTER, E.G. CONCENTRATED URBAN AIR PARTICLES (CAP), DIESEL EXHAUST PARTICLES (DEP) AND TITANIUM DIOXIDE PARTICLES (TIO2), TRIGGER INCREASED ASTHMA RISK IN SEVERAL GENERATIONS OF THE OFFSPRING. HUMANS ARE WIDELY EXPOSED TO THESE PARTICULATES, ESPECIALLY IN URBAN AND INDUSTRIAL SETTINGS, WHERE THE INCIDENCE OF ASTHMA IS ALSO HIGHER. RESEARCHERS FOUND THAT THE INCREASED 'PREPAREDNESS' FOR ASTHMA IN THESE NEONATES IS ASSOCIATED WITH DNA METHYLATION CHANGES IN KEY IMMUNE CELLS DENDRITIC CELLS THAT ARE ESSENTIAL IN ASTHMA ORIGIN. IMPORTANT UNANSWERED QUESTIONS ARE WHY THESE EPIGENETIC CHANGES OCCUR, AND WHETHER THERE IS A CAUSATIVE LINK TO THE ABERRANT MICROBIOME SEEN IN ASTHMA. THE JCVI HYPOTHESIZE THAT IN UTERO EXPOSURES TO PARTICLES ALTER THE MICROBIOME OF THE PREGNANT MICE AND THEIR OFFSPRING, WHICH THEN SIGNALS TO THE IMMUNE CELLS IN A WAY THAT PREDISPOSES THE OFFSPRING TO ALLERGY. WE POSTULATE TWO, POTENTIALLY INTERCONNECTED, MECHANISMS IN ASTHMA ONSET: EPIGENETICS AND THE MICROBIOME. BOTH THE EPIGENETIC ALTERATIONS IN IMMUNE CELLS AND THE DYSBIOSIS IN THE GUT AND LUNG HAVE BEEN LINKED TO ASTHMA IN HUMANS AND MOUSE MODELS BUT CAUSALITY STUDIES ARE LACKING. THE PROPOSED RESEARCH ADDRESSES THIS GAP IN KNOWLEDGE IN A STUDY DESIGNED TO TEST BASIC MECHANISMS OF RELATIVELY COMMON ENVIRONMENTAL EXPOSURES. PROJECT FUNDED THROUGH THE NATIONAL INSTITUTE OF ALLERGY AND IMMUNOLOGY (NIAID/NIH) A DEVELOPMENT OF NOVEL PROTEIN-BASED VACCINE FORMULATIONS TO PREVENT PNEUMOCOCCAL COLONIZATION AND DISEASE WITH COLLABORATOR FROM THE UNIVERSITY OF MARYLAND. ONE OF THE MAJOR PROBLEMS OF THE GREAT BURDEN OF COMMUNITY-ACQUIRED PNEUMONIAS CAUSED BY STREPTOCOCCUS PNEUMONIAE (SPN) INFECTION, IS THE ACQUISITION OF ANTIMICROBIAL RESISTANCE AND THE GLOBAL SPREAD OF RESISTANT VARIANTS. THESE PROBLEMS GET ENHANCED BY THE MAJOR DISADVANTAGES OF THE CURRENT CAPSULAR POLYSACCHARIDE-BASED VACCINES, SUCH AS COST, SEROTYPE SPECIFICITY, AND THE RESULTING INCOMPLETE COVERAGE. THIS OCCURS MAINLY BECAUSE OF DISEASE BEING CAUSED BY SEROTYPES NOT PRESENT IN THE VACCINE (MAXIMUM OF 23 OF THE >97 CAPSULE TYPES, ONLY 13 IN THE CONJUGATE VACCINE) AND REPLACEMENT CARRIAGE. THE RATIONALE FOR THIS PROJECT IS THAT DEVELOPMENT OF A SUBUNIT-BASED VACCINE UTILIZING NOVEL CONSERVED ANTIGENIC PROTEINS IN CONJUNCTION WITH NOVEL POLYPHOSPHAZENE (PPZ) ADJUVANTS, PROVEN TO INDUCE ADAPTIVE IMMUNITY WILL DEEPEN THE CURRENT TOOLKIT TO PREVENT PNEUMOCOCCAL DISEASE WITHOUT SEROTYPE LIMITATIONS. THUS, JCVI HYPOTHESIZE THAT ADDITION OF CONSERVED IMMUNOGENIC PROTEINS TO A POTENT ADJUVANT NANO-MOLECULE WILL PROVIDE THE GROUNDWORK FOR THE DEVELOPMENT OF A BROADLY PROTECTIVE PNEUMOCOCCAL SUBUNIT-BASED VACCINE. (SEE FORM 990, PART III, LINE 4A, PROGRAM SERVICE ACCOMPLISHMENTS CONTINUED).
4b (Code:   ) (Expenses $ 2,611,197 including grants of $ 59,968 ) (Revenue $   )
JCVI IS THE RECIPIENT OF A LARGE COLLABORATIVE ASSISTANCE AWARD FROM THE US DEPARTMENT OF ENERGY. AWARDED TO THE VALUE OF $10.7M. NOW IN ITS 4TH YEAR OF 5,THE JCVI AND ITS COLLABORATORS, COLORADO STATE UNIVERSITY, VANDERBILT UNIVERSITY AND THE UNIVERSITY OF CALIFORNIA, SAN DIEGO, SEEK TO LEVERAGE SIGNIFICANT RECENT ADVANCES IN DIATOM GENOME ENGINEERING AND METABOLIC MODELING; INCLUDING THE ABILITY TO INTRODUCE CHROMOSOME-LIKE EXPRESSION PLATFORMS, WHICH SUBSTANTIALLY ADVANCE POSSIBILITIES FOR HIGH-THROUGHPUT GENERATION AND SCREENING OF GENETICALLY ENGINEERED DIATOMS. RESEARCH PROPOSED HERE WILL RESULT IN DRAMATIC IMPROVEMENTS IN THE PREDICATIVE CAPACITY OF EXISTING GENOME SCALE METABOLIC MODELS OF DIATOM METABOLISM. FOR THE FIRST TIME ON A LARGE SCALE, FLUXOMICS, WHICH IS COMPOUND SPECIFIC INCORPORATION OF AN ISOTOPICALLY-LABELED FEEDSTOCK, WILL BE USED TO PROVIDE BETTER FIRST STEP CONSTRAINTS ON CO2 ASSIMILATION OF IN DIATOMS. STATE-OF-THE-ART HIGH THROUGHPUT IN VITRO EXAMINATIONS OF NEARLY ALL 200 DIATOM TRANSCRIPTION FACTORS WILL BE CONDUCTED TO BETTER UNDERSTAND REGULATORY ARCHITECTURE UNDERLYING DIATOM METABOLISM AS WELL AS SERVE AS A SOURCE FOR NEW TOOLS FOR GENOME ENGINEERING. TAKEN TOGETHER, RESEARCH PROPOSED HERE WILL ADDRESS CURRENTLY LIMITING BOTTLENECKS THROUGH FOSTERING STATE-OF-THE-ART INTEGRATION OF GENOME-SCALE MODELING WITH GENOME ENGINEERING TO OPTIMIZE ENERGY AND METABOLITE FLUX THROUGH SUBCELLULAR COMPARTMENTS TO PROMOTE EFFICIENT PRODUCTION OF HIGH VALUE AND FUEL-RELATED METABOLITES.
4c (Code:   ) (Expenses $ 2,679,430 including grants of $   ) (Revenue $   )
DURING 2020, JCVI HAD MULTIPLE ACTIVE RESEARCH AWARDS FROM THE DEPARTMENT OF DEFENSE (DOD). THESE AWARDS FOCUS ON THE UNDERSTANDING OF POLYMICROBIAL INFECTIONS IN WOUNDS, THE DEVELOPMENT OF SYNTHETIC GENOMIC TECHNOLOGIES FOR MANIPULATION OF CHROMOSOMES AND GENOMES AND FOR THE DEVELOPMENT OF SAFE METHODS FOR DNA ISOLATION AND ANALYSIS FROM BIOTHREAT AGENTS. FUNDED BY THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) THE JCVI IS PROVIDING LONGITUDINAL DNA METHYLATION PROFILING, LONGITUDINAL HISTONE MODIFICATION PROFILING AND LONGITUDINAL METABOLOME PROFILING ON MULTIPLE SAMPLES IN COLLABORATION WITH DARPA FOR THE SELECTING ELITE-PERFORMERS WITH LONGITUDINAL EPIGENOMIC CHARACTERIZATION AND TRACKING (SELECT) PROJECT. WOUND MICROBIOME PROJECT - CHRONIC WOUNDS ARE WOUNDS THAT FAIL TO HEAL AFTER 3 MONTHS UNDER STANDARD OF CARE WOUND MANAGEMENT. THE GOAL OF THIS DOD STUDY IS TO GAIN A BETTER UNDERSTANDING OF THE DIFFERENT CLASSES OF MICROBES THAT COULD BE PRESENT IN HUMAN CHRONIC WOUNDS (I.E. THE WOUND MICROBIOME), AND ASK WHETHER SPECIFIC MICROBES OR MICROBIAL COMMUNITIES ARE ASSOCIATED WITH NON-HEALING WOUNDS. NEXT GENERATION SEQUENCING WILL BE USED TO IDENTIFY AND CATALOG THE MICROBIAL SPECIES OF BACTERIA, FUNGI, AND VIRUSES THAT ARE PRESENT IN CHRONIC WOUND SPECIMENS. COMPUTATIONAL AND BIOINFORMATICS ANALYSES OF THE MICROBIAL COMMUNITY DNA SEQUENCES WILL BE CARRIED OUT TO CHARACTERIZE THE PRESENCE ANY PATHOGENIC, VIRULENCE, AND ANTIMICROBIAL RESISTANCE-RELATED GENES AND PATHWAYS. THE EVENTUAL GOAL IS TO IDENTIFY ANY PATHOGENIC SPECIES OR FEATURES THAT ARE ASSOCIATED WITH NON-HEALING WOUNDS, AND COULD BE USED AS DIAGNOSTIC AND TREATMENT TARGETS OF CHRONIC WOUNDS. SYNTHETIC ENGINEERING OF BACTERIOPHAGE FOR TREATMENT OF WOUND INFECTIONS ANTIMICROBIAL RESISTANCE IN BACTERIAL PATHOGENS IS STEADILY INCREASING AND RECOGNIZED AS ONE OF THE GREATEST THREATS TO GLOBAL PUBLIC HEALTH. SHORTLY AFTER THE BEGINNING OF THE WARS IN AFGHANISTAN AND IRAQ, THE MILITARY HEALTH SYSTEM EXPERIENCED A MAJOR INCREASE IN WOUND AND HEALTHCARE-ASSOCIATED INFECTIONS CAUSED BY MULTIDRUG RESISTANT ORGANISMS (MDROS) WITH EXTREMELY LIMITED TREATMENT OPTIONS. FUNDED THROUGH THE US MEDICAL RESEARCH ACQUISITION ACTIVITY, THE JCVI IN COLLABORATION WITH THE MILITARY AND THE WALTER REED ARMY INSTITUTE OF RESEARCH, IS COLLABORATING WITH THE GOAL TO DESIGN, BUILD, TEST AND CHARACTERIZE NOVEL ENGINEERED BACTERIOPHAGE BIOLOGICS SPECIFICALLY TARGETING MDROS FOR USE AS NOVEL THERAPEUTICS FOR TREATING AND PREVENTING COMBAT WOUND INFECTIONS USING PIONEERING TECHNOLOGY DEVELOPED AT JCVI. THIS OBJECTIVE WILL BE ACCOMPLISHED THROUGH EXPERIMENTS FOCUSED ON PRODUCING SYNTHETICALLY ENGINEERED PHAGE WITH AN ENHANCED HOST RANGE SUFFICIENT TO COVER CURRENT AND FUTURE CIRCULATING MDR STRAINS OF S. AUREUS AND K. PNEUMONIAE COMMONLY FOUND IN THE MILITARY HEALTH SYSTEM, INCLUDING METHICILLIN-RESISTANT S. AUREUS AND CARBAPENEM-RESISTANT K. PNEUMONIAE STRAINS. CANDIDATE ENGINEERED THERAPEUTIC PHAGE CHASSIS WILL BE PRODUCED, CHARACTERIZED AND TESTED IN MOUSE WOUND INFECTION MODELS BY RESEARCHERS AT WRAIR AS A PRELUDE TO FUTURE HUMAN USE. IT IS ANTICIPATED THAT WE WILL DEVELOP ONE OR MORE PHAGE CHASSIS CAPABLE OF SPECIFICALLY TARGETING AND KILLING EACH PATHOGEN BOTH IN VITRO AND IN VIVO."
(Code:   ) (Expenses $ 3,873,475 including grants of $   ) (Revenue $   )
OTHER PROGRAM SERVICES IN THE JCVI RESEARCH PORTFOLIO ALSO INCLUDED SUPPORT FROM FOUNDATIONS AND INDUSTRIAL COLLABORATIONS.: NATIONAL SCIENCE FOUNDATION COLLABORATIVE RESEARCH: IRON BIOAVAILABILITY IN HIGH-CO2 OCEANS: NEW PERSPECTIVES ON IRON ACQUISITION MECHANISMS IN DIATOMS WITH THIS PROJECT THE JCVI SEEKS TO UNDERSTAND THE DIFFERENTIAL SENSITIVITY OF DIATOM IRON ACQUISITION STRATEGIES TO CHANGES IN SEAWATER PH AND CARBONATE CHEMISTRY. ULTIMATELY A MORE THOROUGH AND DETAILED MECHANISTIC UNDERSTANDING OF DIATOM IRON UPTAKE PATHWAYS WILL FACILITATE A MUCH-IMPROVED ABILITY TO FORECAST THE IMPACT OF ANTICIPATED CHANGES IN OCEAN PH AND INORGANIC CARBON CHEMISTRY ON RATES OF IRON UPTAKE BY DIATOMS. THIS CRITICAL BIOGEOCHEMICAL ISSUE IS ADDRESSED THROUGH TRACE METAL CLEAN MANIPULATION EXPERIMENTS INCORPORATING STATE-OF-THE-ART ANALYTICAL METHODOLOGY TO PROBE PHYTOPLANKTON CELLULAR PHYSIOLOGY AND BIOGEOCHEMISTRY IN LABORATORY CULTURES AND NATURAL COMMUNITIES. IN THE FIRST YEAR, LABORATORY EXPERIMENTS WITH A MODEL PENNATE DIATOM LEVERAGE A COLLECTION OF TARGETED KNOCKOUT TRANSGENIC LINES TO EVALUATE THE SUBSTRATE SPECIFICITY AND RELATIVE IMPORTANCE OF DISTINCT IRON ASSIMILATION PATHWAYS UNDER A RANGE OF PCO2 AND IRON AVAILABILITY CONDITIONS. ADDITIONALLY, QUANTITATION OF MRNA AND PROTEINS FOR KEY DIATOM IRON ASSIMILATION PATHWAYS IN NATURAL COMMUNITIES IN THE SOUTHERN CALIFORNIA CURRENT FURTHER CLARIFY THE RELATIVE IMPORTANCE AND SENSITIVITY OF DISTINCT IRON ASSIMILATION PATHWAYS IN RELATION TO PCO2 AND IRON AVAILABILITY. IN YEAR TWO A LAGRANGIAN STUDY OF IRON UPTAKE RATES AND ASSOCIATED MRNA AND PROTEIN ABUNDANCE IS PERFORMED ON UPWELLED HIGH PCO2 WATER OVER THE COURSE OF OFFSHORE ADVECTION. ADDITIONALLY, WE CONDUCT MESOCOSM EXPERIMENTS USING NATURALLY ELEVATED HIGH PCO2 SEAWATER AS WELL AS LABORATORY EXPERIMENTS ON MULTIPLEX KNOCKOUT LINES. YEAR THREE IS DEDICATED TO DATA ANALYSES AND OVERALL PROJECT SYNTHESIS. OVERALL AIMS OF THE RESEARCH ACTIVITIES INCLUDE, 1) DEVELOPMENT AND VALIDATION OF A REFINED CONCEPTUAL MODEL OF IRON UPTAKE IN KEY MARINE PHYTOPLANKTON AND SUBSEQUENT UTILIZATION OF THE MODEL TO CHARACTERIZE THE SENSITIVITY OF DISTINCT IRON UPTAKE PATHWAYS TO THE EFFECTS OF OCEAN ACIDIFICATION, AND 2) DETERMINATION OF THE EFFECTS OF ACIDIFICATION ON IRON UPTAKE, AND QUANTIFICATION OF THE RELATIVE CONTRIBUTION OF DISTINCT IRON ACQUISITION PATHWAYS IN HIGH PCO2 PHYTOPLANKTON COMMUNITIES. GORDON AND BETTY MOORE FOUNDATION GENETIC DIVERSITY IS A HALLMARK OF ADAPTABILITY; THE RIGHT AMOUNT GIVES A THEORETICAL ADVANTAGE IN SHIFTING ENVIRONMENTS. HOWEVER, TOO MUCH DIVERSITY MAY LEAD TO DECREASED FITNESS RESULTING FROM GENETIC BOTTLENECKS, KNOWN AS MULLER'S RATCHET. THE EXTENT OF GENETIC VARIATION AMONG INDIVIDUALS CAN SET A SPECIES' ADAPTIVE POTENTIAL AND INFLUENCE ITS PERSISTENCE OVER TIME. FOR THESE REASONS, THE AMOUNT OF GENETIC VARIABILITY WITHIN SPECIES HAS BEEN A FOCUS OF POPULATION GENETICS AND EVOLUTIONARY BIOLOGY FOR NEARLY 100 YEARS. FROM AN ECOLOGICAL PERSPECTIVE, RECENT WORK IN BOTH TERRESTRIAL AND MARINE SYSTEMS HAS SHOWN THAT INTRASPECIFIC GENETIC DIVERSITY CAN MODULATE INTERSPECIFIC INTERACTIONS AND THUS INFLUENCE LEVELS OF PRIMARY PRODUCTIVITY AND FUNCTIONAL RESPONSES TO CHANGING ENVIRONMENTS. THESE COMPLEXITIES GUIDE OUR RATIONALE FOR SEEKING CELLULAR-LEVEL DATA TO ADDRESS HIGHER-ORDER ECO-EVOLUTIONARY DYNAMICS. IN THIS PROJECT, FUNDED BY THE GORDON AND BETTY MOORE FOUNDATION, THE JCVI HAVE TAKEN A CELLULAR APPROACH TO CAPTURE GENETIC DIVERSITY OF A MARINE EUKARYOTIC PHYTOPLANKTON POPULATION OF CYLINDROTHECA. DURING THIS WORK, JCVI HAS ISOLATED NOVEL RNA VIRUSES INFECTING THIS DIATOM AND GENERATED HOST/VIRUS GENOMIC AND TRANSCRIPT EXPRESSION DATA. JCVI HAVE ALSO DEVELOPED NEW AND MORE EFFICIENT METHODS FOR OBTAINING THESE DATA. USING THIS INFORMATION, WE HAVE EMPIRICALLY DERIVED THE HETEROGENEOUS NATURE OF PHYTOPLANKTON POPULATIONS AND GAINED INSIGHT INTO HOW THE INDIVIDUAL'S METABOLIC CAPACITY MAY NOT TRANSLATE TO THE POPULATION AS A WHOLE. THE LARRY L HILLBOM FOUNDATION - OVER THE LAST FEW YEARS, ADVANCES IN STEM CELL RESEARCH AND SYNTHETIC BIOLOGY HAVE CATALYZED AN EXTRAORDINARY EXPANSION OF ORGANOID TECHNOLOGY THAT IS BRINGING CHANGES TO TRANSLATIONAL MEDICINE, PHARMACEUTICAL RESEARCH, AND STRATEGIES FOR TREATING VARIOUS HUMAN PATHOLOGIES. USING STEM CELLS, ORGANOIDS HAVE BEEN DEVELOPED FOR MULTIPLE ORGANS INCLUDING LIVER, INTESTINE, KIDNEY, BRAIN, STOMACH, SKIN, OVARY, AND LUNG (1). A NETWORK OF SCIENTISTS LED BY THE JCVI AND IN COLLABORATION WITH STANFORD UNIVERSITY, UNIVERSITY OF CALIFORNIA, SAN DIEGO, AND THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ARE DEVELOPING ORGANOIDS THAT CAN SERVE AS SURROGATES FOR BETA CELLS, WHICH ARE THE CELLS IN THE HUMAN PANCREAS THAT CONTROL BLOOD GLUCOSE LEVELS BY SYNTHESIZING INSULIN. THE GOAL IS THAT THESE ORGANOIDS, WHEN IMPLANTED IN TYPE 1 DIABETICS (T1D), WILL RESULT IN A BETTER TREATMENT AND BETTER LIVES FOR THOSE PATIENTS. THE INSULIN INFUSION PUMPS USED BY MANY T1D PATIENTS ARE IN ESSENCE, MECHANICAL ORGANOIDS. WHILE EFFECTIVE, THEY DO NOT COMPLETELY PROTECT THE PATIENTS FROM THE LONG-TERM EFFECTS OF THE DISEASE OR ENABLE A NORMAL NONDIABETIC LIFESTYLE. IN T1D PATIENTS, THE PANCREATIC BETA CELLS ARE DESTROYED BY AN AUTOIMMUNE RESPONSE. ONE THEME OF RESEARCH FOR MANY YEARS HAS BEEN TO TRANSPLANT BETA CELLS FROM CADAVERS INTO DIABETIC PATIENTS. MORE RECENTLY, RESEARCHERS ARE DEVELOPING METHODS TO PROGRAM STEM CELLS TO BECOME BETA CELLS THAT WOULD BE TRANSPLANTED INTO PATIENTS. FOR THIS TO BE SUCCESSFUL, THE PATIENTS ARE FORCED TO TAKE IMMUNOSUPPRESSIVE DRUGS FOR THE REST OF THEIR LIVES, OR TO SEQUESTER THE TRANSPLANTED BETA CELLS FROM THE PATIENT'S IMMUNE SYSTEM BY PLACING THEM IN PLASTIC CAPSULES. NEITHER OF THESE APPROACHES HAVE PROVEN SATISFACTORY. SUPPORT FROM LARRY L HILLBOM FOUNDATION IS ENABLING THE RESEARCH TEAM TO TEST TWO NOVEL APPROACHES TO MAKE INSULIN-PRODUCING BIOLOGICAL ORGANOIDS THAT WOULD CONTROL DIABETICS' BLOOD GLUCOSE LEVELS BUT NOT BE AFFECTED BY THE PATIENTS' AUTOIMMUNE SYSTEM, WHICH KILLED THE PATIENTS' NATURAL BETA CELLS. THE FIRST APPROACH IS TO USE STEM CELL AND SYNTHETIC BIOLOGY TECHNOLOGY TO DEVELOP ORGANOIDS THAT RESEMBLE THE EYE AND USE THEM TO HOUSE BETA CELLS. THE EYE IS A WELL-CHARACTERIZED "IMMUNE PRIVILEGE" SITE WHERE IMMUNE ACTIVITY IS REDUCED TO ALLOW FOR OTHER ESSENTIAL FUNCTIONS. THE GENERATED EYE/BETA CELL ORGANOIDS WILL BE IMPLANTED IN THE PATIENT'S SKIN AND REPLACE THE CURRENT INSULIN INFUSION THERAPY. THE SECOND APPROACH CAPITALIZES ON THE RECENT DISCOVERY BY THE RESEARCH TEAM THAT BACTERIA LIVE IN THE DEEPEST LAYERS OF THE SKIN. WE PROPOSE TO HARVEST THOSE BACTERIA AND USING SYNTHETIC BIOLOGY, GENETICALLY ENGINEER THEM TO SENSE BLOOD GLUCOSE IN THE SKIN AND SYNTHESIZE INSULIN IN RESPONSE TO ELEVATED GLUCOSE LEVELS. THEY WOULD BE ORGANOIDS THAT ARE LIKE NATURAL BETA CELLS, BUT NOT AFFECTED BY PATIENTS' AUTOIMMUNE RESPONSES. ORGANOIDS FROM BOTH APPROACHES SHOULD ENABLE AN AUTONOMOUS, CLOSED-LOOP SYSTEMS THAT ARE NOT MACHINEBASED WITH NO PAINFUL NEEDLES AND NO SENSATION OF WEARING A DEVICE. WE BELIEVE THAT ORGANOID-BASED THERAPIES COULD BE A BREAKTHROUGH THAT WILL BRING NORMAL LIFESTYLES TO T1D PATIENTS.SYNTHETIC-GESTALT - MORE AND MORE CHEMICALS TO SUPPORT VARIOUS INDUSTRIES WILL COME FROM ENGINEERED BACTERIA IN THE FUTURE, BUT CONCERNS REMAIN ABOUT THE SAFETY OF THE ORGANISMS OR UNINTENDED BYPRODUCTS. MINIMAL BACTERIAL CELLS OFFER A UNIQUE PLATFORM FOR BIOPRODUCTION. BECAUSE A LARGER FRACTION OF BIOLOGICAL PROCESSES ARE UNDERSTOOD IN THESE SIMPLE CELLS, THEY CAN EASILY BE MADE SAFE AND MORE EFFICIENT IN PRODUCING TARGET COMPOUNDS. THE COLLABORATION BETWEEN SYNTHETIC GESTALT AND JCVI IN 2020 LED TO THE DEVELOPMENT OF A DIGITAL TWIN, A COMPUTATIONAL MODEL, FOR A MINIMAL CELL THAT CAN BE USED TO OPTIMIZE METABOLIC REACTIONS IN THE CELL. THIS RESEARCH ALSO GAVE RISE TO STRAINS WITH METABOLIC PATHWAY GENES ADDED FROM OUTSIDE TOWARD ESTABLISHING A MINIMAL BACTERIAL CELL AS A FUTURE INDUSTRIAL PRODUCTION HOST.
4d Other program services (Describe in Schedule O.)
(Expenses $ 3,873,475 including grants of $   ) (Revenue $   )
4e Total program service expensesMediumBullet17,028,890
Form 990 (2020)
Form 990 (2020)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule AClick to see attachment.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors (see instructions)? Click to see attachment...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part I.............
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part II.........
4
 
No
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Revenue Procedure 98-19? If "Yes," complete Schedule C, Part III..
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part IClick to see attachment.........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part IIClick to see attachment....
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes,"
complete Schedule D, Part IIIClick to see attachment..............
8
Yes
 
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IVClick to see attachment..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi endowments? If "Yes," complete Schedule D, Part V......
10
 
No
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete
Schedule D, Part VI. Click to see attachment...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIClick to see attachment.......
11b
 
No
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIIClick to see attachment.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IXClick to see attachment............
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part XClick to see attachment
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part XClick to see attachment
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XIIClick to see attachment......................
12a
Yes
 
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
12b
 
No
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States? .....
14a
 
No
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV.........Click to see attachment
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV.....Click to see attachment
15
Yes
 
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV...Click to see attachment
16
 
No
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I(see instructions) ....
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....
20a
 
No
b
If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
21
Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II.....Click to see attachment
21
Yes
 
Form 990 (2020)
Form 990 (2020)
Page 4
Part IV
Checklist of Required Schedules (continued)
Yes
No
22
Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........Click to see attachment
22
 
No
23
Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5 about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a...............
24a
 
No
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
 
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............
24c
 
 
d
Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...
24d
 
 
25a
Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I ....
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I.......................
25b
 
No
26
Did the organization report any amount on Part X, line 5 or 22 for receivables from or payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II...........
26
 
No
27
Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or employee thereof, a grant selection committee member, or to a 35% controlled entity (including an employee thereof) or family member of any of these persons?
If "Yes," complete
Schedule L, Part III.........................
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If "Yes," complete Schedule L, Part IV......................
28a
 
No
b
A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV.....
28b
 
No
c
A 35% controlled entity of one or more individuals and/or organizations described in lines 28a or 28b? If "Yes," complete Schedule L, Part IV.....................
28c
 
No
29
Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M..
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M .................
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II........................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I............Click to see attachment
33
 
No
34
Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1.........................Click to see attachment
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
Yes
 
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ...Click to see attachment
35b
 
No
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2............. Click to see attachment
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VIClick to see attachment
37
 
No
38
Did the organization complete Schedule O and provide explanations in Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........
Yes
No
1a
Enter the number reported in Box 3 of Form 1096. Enter -0- if not applicable ..
1a
56
b
Enter the number of Forms W-2G included in line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
Form 990 (2020)
Form 990 (2020)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance (continued)
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
180
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file (see instructions)
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
Yes
 
b
If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...
3b
Yes
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..
4a
 
No
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...
6a
 
No
b
If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................
7a
 
No
b
If "Yes," did the organization notify the donor of the value of the goods or services provided? .....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................
7c
 
No
d
If "Yes," indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? ........
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the sponsoring organization make any taxable distributions under section 4966?........
9a
 
 
b
Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If "Yes," enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state? .........
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..
14b
 
 
15
Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or excess parachute payment(s) during the year? ....................
If "Yes," see instructions and file Form 4720, Schedule N.
15
Yes
 
16
Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ..
If "Yes," complete Form 4720, Schedule O.
16
 
No
Form 990 (2020)
Form 990 (2020)
Page 6
Part VI
Governance, Management, and Disclosure For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI..............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year
1a
8
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent
1b
5
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
Yes
 
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? .
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
 
No
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
 
No
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
 
No
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .......................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
Yes
 
b
Describe in Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If "No," go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe in Schedule O how this was done...................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process in Schedule O (see instructions).
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the states with which a copy of this Form 990 is required to be filedMediumBullet
CA , MD
18
Section 6104 requires an organization to make its Form 1023 (or 1024-A if applicable), 990, and 990-T (501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBulletDR JOHN CRAIG VENTER4120 CAPRICORN LANE   LA JOLLA,CA92037 (858) 200-1800
Form 990 (2020)
Form 990 (2020)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII..............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (Box 5 of Form W-2 and/or Box 7 of Form 1099-MISC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

See instructions for the order in which to list the persons above.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W-2/1099-MISC) 		(E)
Reportable compensation from related organizations (W-2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(1) VENTER JOHN CRAIG......................................................................
CHAIRMAN & CEO
 40.00
.................
  		X   X       1,194,335 0 45,300
(2) NELSON KAREN......................................................................
PRESIDENT
 40.00
.................
  		X   X       711,001 0 61,532
(3) KOWALSKI HEATHER......................................................................
CHIEF OPERATING OFFICER
 40.00
.................
  		X   X       449,321 0 36,738
(4) MULLEN JILL......................................................................
SR. VP OF PHILANTHROPY AND STRATEGIC ALLIANCES
 40.00
.................
  		        X   350,060 0 63,009
(5) SCHEUERMANN RICHARD H......................................................................
DIRECTOR, LA JOLLA CAMPUS
 40.00
.................
  		      X     348,827 0 56,459
(6) STOUT MARTIN......................................................................
CHIEF TECHNOLOGY OFFICER
 40.00
.................
  		      X     308,171 0 36,227
(7) PEAKE ANTONY G......................................................................
VP FOR RESEARCH ADMINISTRATION
 40.00
.................
  		      X     294,523 0 30,633
(8) YUMULMARY......................................................................
VP OF HUMAN RESOURCES
 40.00
.................
  		        X   253,229 0 65,398
(9) KIRKNESS EWEN......................................................................
PROFESSOR
 40.00
.................
  		        X   257,034 0 54,754
(10) STAYEAS TIMOTHY......................................................................
NETWORK TEAM LEAD
 40.00
.................
  		        X   214,440 0 60,471
(11) ADELSON JULIE......................................................................
VP, LEG. AFFRS/GENERAL COUNSEL
 40.00
.................
  		    X       210,151 0 36,765
(12) PRATTE EDWARD......................................................................
DIRECTOR OF SECURITY
 40.00
.................
  		        X   226,695 0 7,187
(13) FRIEDMAN ROBERT M......................................................................
VP FOR POLICY & UNIV. RELATIONS
 40.00
.................
  		      X     143,182 0 52,666
(14) BADR-EL-DIN AMIN PHD......................................................................
TRUSTEE
 4.00
.................
  		X           0 0 0
(15) HOROWITZREENA......................................................................
TRUSTEE (THRU 2/27/2020)
 4.00
.................
  		X           0 0 0
(16) KNIGHT JESSIE......................................................................
TRUSTEE (THRU 2/27/2020)
 4.00
.................
  		X           0 0 0
(17) MCGRORY JACK......................................................................
TRUSTEE
 4.00
.................
  		X           0 0 0
Form 990 (2020)
Form 990 (2020)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W-2/1099-MISC) 		(E)
Reportable compensation from related organizations (W-2/1099-MISC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(18) NORRBY ERLING........................................................................
TRUSTEE
 4.00
.......................   		X           0 0 0
(19) RUGGLES RUDY........................................................................
TRUSTEE
 4.00
.......................   		X           0 0 0
(20) WEI WU........................................................................
TRUSTEE (AS OF 2/27/2020)
 4.00
.......................   		X           0 0 0




















1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)...........MediumBullet 4,960,969 0 607,139
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet58
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............
3
 
No
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........
5
 
No
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
TB CONSULTING

8328 E HARTFORD DRIVE SUITE 102
SCOTTSDALE,AZ85255 		COMPUTER SERVICE CONSULTANT 216,901
MOSS ADAMS LLP

4747 EXECUTIVE DRIVE SUITE 1300
SAN DIEGO,CA92121 		ACCOUNTING AND AUDIT SERVICES 165,285
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet2
Form 990 (2020)
Form 990 (2020)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII.............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512 - 514
Contributions, Gifts, GrantAmt and OtherAmt Similar Amounts 1a Federated campaigns..1a  
b Membership dues..1b  
c Fundraising events..1c  
d Related organizations1d  
e Government grants (contributions)1e 15,140,853
f All other contributions, gifts, grants, and similar amounts not included above1f 3,472,566
g Noncash contributions included in lines 1a - 1f:$ 1g  
h Total. Add lines 1a-1f.......MediumBullet 18,613,419
Program Service RevenueAmt Business Code
2a SEQUENCING SERVICES REVENUE 900099 120,988 120,988    
b CLONE REVENUE 900099 2,667 2,667    
c
d
e
f All other program service revenue.        
g Total. Add lines 2a–2f .....MediumBullet 123,655
OtherAmtRevenueAmt 3 Investment income (including dividends, interest, and othersimilar amounts) ......MediumBullet 905,885     905,885
4 Income from investment of tax-exempt bond proceedsMediumBullet        
5 Royalties...........MediumBullet        
(ii) Personal (i) Real
6a Gross rents     6a
b Less: rental expenses     6b
c Rental income or (loss)     6c
d Net rental income or (loss).......MediumBullet        
(ii) Other (i) Securities
7a Gross amount from sales of assets other than inventory 95,018 8,729,641 7a
b Less: cost or other basis and sales expenses 2,091 10,552,212 7b
c Gain or (loss) 92,927 -1,822,571 7c
d Net gain or (loss).........MediumBullet -1,729,644     -1,729,644
8a Gross income from fundraising events (not including $   of contributions reported on line 1c). See Part IV, line 18 ....
8a  
b Less: direct expenses ... 8b  
c Net income or (loss) from fundraising events..MediumBullet      
9a Gross income from gaming activities.
See Part IV, line 19 ...
9a  
b Less: direct expenses ... 9b  
c Net income or (loss) from gaming activities..MediumBullet        
10a Gross sales of inventory, less
returns and allowances ..
10a  
b Less: cost of goods sold .. 10b  
c Net income or (loss) from sales of inventory..MediumBullet        
Business Code Miscellaneous Revenue
11a K-1 PASSTHROUGH 900099 15,294   15,294  
b            
c            
d All other revenue ....        
e Total. Add lines 11a–11d ...... MediumBullet 15,294
12 Total revenue. See instructions.....MediumBullet 17,928,609 123,655 15,294 -823,759
Form 990 (2020)
Form 990 (2020)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX..............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising
expenses
1 Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 .... 2,782,839 2,782,839
2 Grants and other assistance to domestic individuals. See Part IV, line 22 ...........    
3 Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. ............. 59,968 59,968
4 Benefits paid to or for members .......    
5 Compensation of current officers, directors, trustees, and key employees ........... 4,015,830 1,037,747 2,945,546 32,537
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........        
7 Other salaries and wages........ 12,209,265 7,678,994 4,135,691 394,580
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 407,174 202,230 182,191 22,753
9 Other employee benefits ....... 1,476,838 674,939 706,100 95,799
10 Payroll taxes ........... 1,015,671 430,211 537,894 47,566
11 Fees for services (non-employees):        
a Management ......        
b Legal ......... 54,871   54,871  
c Accounting ........... 133,112   133,112  
d Lobbying ...........        
e Professional fundraising services. See Part IV, line 17    
f Investment management fees ...... 108,379   108,379  
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) 210,121 70,000 140,121  
12 Advertising and promotion .... 37,579   37,579  
13 Office expenses ....... 361,311 121,628 221,868 17,815
14 Information technology ...... 973,958 31,911 942,047  
15 Royalties ..        
16 Occupancy ........... 2,041,396 1,371,259 626,438 43,699
17 Travel ............ 30,595 17,920 4,647 8,028
18 Payments of travel or entertainment expenses for any federal, state, or local public officials .        
19 Conferences, conventions, and meetings .... 52,041 44,395 6,505 1,141
20 Interest ........... 66,954   66,954  
21 Payments to affiliates .......        
22 Depreciation, depletion, and amortization .. 2,051,976 1,051,885 984,247 15,844
23 Insurance ... 477,540 108,701 366,868 1,971
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a LAB EQUIPMENT/SUPPLIES 1,726,041 1,335,945 390,096  
b BOOKS AND SUBSCRIPTIONS 26,646 36 21,646 4,964
c
d
e All other expenses 54,674 8,282 46,277 115
25 Total functional expenses. Add lines 1 through 24e 30,374,779 17,028,890 12,659,077 686,812
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2020)
Form 990 (2020)
Page 11
Part X
Balance Sheet
Check if Schedule O contains a response or note to any line in this Part IX..............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash–non-interest-bearing ........ 4,765,643 1 2,188,334
2 Savings and temporary cash investments ......... 12,285,562 2 7,177,016
3 Pledges and grants receivable, net ...... 3,868,838 3 4,135,631
4 Accounts receivable, net ............. 260,317 4 16,925
5 Loans and other receivables from any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
  5  
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
  6  
7 Notes and loans receivable, net ...........   7  
8 Inventories for sale or use ............   8  
9 Prepaid expenses and deferred charges ...... 1,022,612 9 884,675
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 69,065,155
b Less: accumulated depreciation 10b 24,415,322 46,530,181 10c 44,649,833
11 Investments—publicly traded securities . 36,161,170 11 37,353,456
12 Investments—other securities. See Part IV, line 11 ..... 1,253,071 12 1,087,432
13 Investments—program-related. See Part IV, line 11 ..   13  
14 Intangible assets ...............   14  
15 Other assets. See Part IV, line 11 ........... 2,840,214 15 2,776,513
16 Total assets. Add lines 1 through 15 (must equal line 33)... 108,987,608 16 100,269,815
Liabilities 17 Accounts payable and accrued expenses ..... 6,031,343 17 4,481,086
18 Grants payable ...   18  
19 Deferred revenue ......... 2,528,751 19 2,353,045
20 Tax-exempt bond liabilities .........   20  
21 Escrow or custodial account liability. Complete Part IV of Schedule D   21  
22 Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
  22  
23 Secured mortgages and notes payable to unrelated third parties .. 26,524,485 23 24,942,805
24 Unsecured notes and loans payable to unrelated third parties ..   24  
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D 82,679 25 5,077,885
26 Total liabilities. Add lines 17 through 25.. 35,167,258 26 36,854,821
Net Assets or Fund Balance Organizations that follow FASB ASC 958, check here MediumBullet and complete lines 27, 28, 32, and 33.
27 Net assets without donor restrictions .......... 73,084,655 27 62,937,864
28 Net assets with donor restrictions ........... 735,695 28 477,130
Organizations that do not follow FASB ASC 958, check here MediumBullet and complete lines 29 through 33.
29 Capital stock or trust principal, or current funds .....   29  
30 Paid-in or capital surplus, or land, building or equipment fund ...   30  
31 Retained earnings, endowment, accumulated income, or other funds   31  
32 Total net assets or fund balances ........... 73,820,350 32 63,414,994
33 Total liabilities and net assets/fund balances ........ 108,987,608 33 100,269,815
Form 990 (2020)
Form 990 (2020)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI..............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
17,928,609
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
30,374,779
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
-12,446,170
4
Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ..
4
73,820,350
5
Net unrealized gains (losses) on investments ...............
5
2,056,108
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
-15,294
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32, column (B))
10
63,414,994
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII.............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain in
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
Yes
 
b
If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.
3b
Yes
 
Form 990 (2020)
Form 990 (2020)
Additional Data


Software ID:  
Software Version:  
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990 or 990EZ)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ.
right arrow Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2020
Open to Public
Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)
1
2
3
4
5
6
7
8
9
10
11
12
a
b
c
d
e
f
Enter the number of supported organizations ...............................  
g
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 10 above (see instructions)) (iv) Is the organization listed in your governing document? (v) Amount of monetary support (see instructions) (vi) Amount of other support (see instructions)
Yes No
Total
 
   
For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.
Cat. No. 11285F
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2016 (b) 2017 (c) 2018 (d) 2019 (e) 2020 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") .. 26,768,604 20,421,917 30,012,027 21,442,951 18,613,419 117,258,918
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3 26,768,604 20,421,917 30,012,027 21,442,951 18,613,419 117,258,918
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f).. 4,002,103
6 Public support. Subtract line 5 from line 4. 113,256,815
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2016 (b) 2017 (c) 2018 (d) 2019 (e) 2020 (f) Total
7 Amounts from line 4.. 26,768,604 20,421,917 30,012,027 21,442,951 18,613,419 117,258,918
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... 1,482,196 1,373,809 1,387,304 1,158,537 905,885 6,307,731
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..            
11 Total support. Add lines 7 through 10 123,566,649
12
12
1,757,477
13
First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here........................................right arrow
Section C. Computation of Public Support Percentage
14
14
91.660 %
15
15
76.300 %
16a
b
17a
b
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2016 (b) 2017 (c) 2018 (d) 2019 (e) 2020 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose            
3 Gross receipts from activities that are not an unrelated trade or business under section 513 .....            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge            
6 Total. Add lines 1 through 5            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support. (Subtract line 7c from line 6.)  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2016 (b) 2017 (c) 2018 (d) 2019 (e) 2020 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included in line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
b
20
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 4
Part IV
Supporting Organizations
(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, of Part I, complete Sections A and B. If you checked box 12b, of Part I, complete Sections A and C. If you checked box 12c, of Part I, complete Sections A, D, and E. If you checked box12d, of Part I, complete Sections A and D, and complete Part V.)
Section A. All Supporting Organizations
Yes
No
1
Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.
1
 
 
2
Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).
2
 
 
3a
Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer lines 3b and 3c below.
3a
 
 
b
Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.
3b
 
 
c
Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.
3c
 
 
4a
Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below.
4a
 
 
b
Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.
4b
 
 
c
Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.
4c
 
 
5a
Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).
5a
 
 
b
Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?
5b
 
 
c
Substitutions only. Was the substitution the result of an event beyond the organization's control?
5c
 
 
6
Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.
6
 
 
7
Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ) .
7
 
 
8
Did the organization make a loan to a disqualified person (as defined in section 4958) not described in line 7? If “Yes,” complete Part I of Schedule L (Form 990 or 990-EZ).
8
 
 
9a
Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons, as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.
9a
 
 
b
Did one or more disqualified persons (as defined in line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.
9b
 
 
c
Did a disqualified person (as defined in line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.
9c
 
 
10a
Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.
10a
 
 
b
Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).
10b
 
 
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 5
Part IV
Supporting Organizations (continued)
Yes
No
11
Has the organization accepted a gift or contribution from any of the following persons?
a
A person who directly or indirectly controls, either alone or together with persons described in lines 11b and 11c below, the governing body of a supported organization?
11a
 
 
b
A family member of a person described in 11a above?
11b
 
 
c
A 35% controlled entity of a person described in line 11a or 11b above? If “Yes” to 11a, 11b, or 11c, provide detail in Part VI.
11c
 
 
Section B. Type I Supporting Organizations
Yes
No
1
Did the officers, directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.
1
 
 
2
Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.
2
 
 
Section C. Type II Supporting Organizations
Yes
No
1
Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).
1
 
 
Section D. All Type III Supporting Organizations
Yes
No
1
Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?
1
 
 
2
Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).
2
 
 
3
By reason of the relationship described in line 2 above, did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.
3
 
 
Section E. Type III Functionally-Integrated Supporting Organizations
1
Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):
a
b
c
2
Activities Test. Answer lines 2a and 2b below.
Yes
No
a
Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.
2a
 
 
b
Did the activities described in line 2a, above constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.
2b
 
 
3
Parent of Supported Organizations. Answer lines 3a and 3b below.
a
Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations?If "Yes" or "No", provide details in Part VI.
3a
 
 
b
Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.
3b
 
 
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 6
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations
1
Section A - Adjusted Net Income (A) Prior Year (B) Current Year
(optional)
1 Net short-term capital gain 1    
2 Recoveries of prior-year distributions 2    
3 Other gross income (see instructions) 3    
4 Add lines 1 through 3 4    
5 Depreciation and depletion 5    
6 Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) 6    
7 Other expenses (see instructions) 7    
8 Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) 8    
Section B - Minimum Asset Amount (A) Prior Year (B) Current Year
(optional)
1 Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): 1
a Average monthly value of securities 1a    
b Average monthly cash balances 1b    
c Fair market value of other non-exempt-use assets 1c    
d Total (add lines 1a, 1b, and 1c) 1d    
e Discount claimed for blockage or other factors
(explain in detail in Part VI):  
2 Acquisition indebtedness applicable to non-exempt use assets 2    
3 Subtract line 2 from line 1d 3    
4 Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions). 4    
5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5    
6 Multiply line 5 by 0.035 6    
7 Recoveries of prior-year distributions 7    
8 Minimum Asset Amount (add line 7 to line 6) 8    
Section C - Distributable Amount Current Year
1 Adjusted net income for prior year (from Section A, line 8, Column A) 1  
2 Enter 85% of line 1 2  
3 Minimum asset amount for prior year (from Section B, line 8, Column A) 3  
4 Enter greater of line 2 or line 3 4  
5 Income tax imposed in prior year 5  
6 Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) 6  
7
Schedule A (Form 990 or 990-EZ) 2020

Schedule A (Form 990 or 990-EZ) 2020
Page 7
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)
Section D - Distributions Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes 1  
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in
excess of income from activity 		2  
3 Administrative expenses paid to accomplish exempt purposes of supported organizations 3  
4 Amounts paid to acquire exempt-use assets 4  
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI) 5  
6 Other distributions (describe in Part VI). See instructions 6  
7Total annual distributions. Add lines 1 through 6. 7  
8 Distributions to attentive supported organizations to which the organization is responsive (provide
details in Part VI). See instructions 		8  
9 Distributable amount for 2020 from Section C, line 6 9  
10 Line 8 amount divided by Line 9 amount 10  
Section E - Distribution Allocations (see instructions) (i)
Excess Distributions 		(ii)
Underdistributions
Pre-2020 		(iii)
Distributable
Amount for 2020
1 Distributable amount for 2020 from Section C, line 6  
2 Underdistributions, if any, for years prior to 2019 (reasonable cause required-- explain in Part VI).
See instructions.		  
3 Excess distributions carryover, if any, to 2020:
a From 2015.......  
b From 2016.......  
c From 2017.......  
d From 2018.......  
e From 2019.......  
fTotal of lines 3a through e  
g Applied to underdistributions of prior years  
h Applied to 2020 distributable amount  
i Carryover from 2015 not applied (see
instructions) 		 
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.  
4Distributions for 2020 from Section D, line 7:
$  
a Applied to underdistributions of prior years  
b Applied to 2020 distributable amount  
c Remainder. Subtract lines 4a and 4b from line 4.  
5 Remaining underdistributions for years prior to
2020, if any. Subtract lines 3g and 4a from line 2.
If the amount is greater than zero, explain in Part VI.
See instructions. 		 
6 Remaining underdistributions for 2020. Subtract
lines 3h and 4b from line 1. If the amount is greater
than zero, explain in Part VI. See instructions. 		 
7 Excess distributions carryover to 2021. Add lines
3j and 4c. 		 
8 Breakdown of line 7:
a Excess from 2016.....  
b Excess from 2017.....  
c Excess from 2018.....  
d Excess from 2019.....  
e Excess from 2020.....  
Schedule A (Form 990 or 990-EZ) (2020)

Schedule A (Form 990 or 990-EZ) 2020
Page 8
Part VI
Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Return Reference Explanation
Schedule A (Form 990 or 990-EZ) 2020


Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990, 990-EZ,
or 990-PF)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors

Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
Arrow Bullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2020
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ






Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......... Arrow Bullet $  
Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990, 990-EZ, or 990-PF) (2020)
Schedule B (Form 990, 990-EZ, or 990-PF) (2020) Page 2
Name of organization
J CRAIG VENTER INSTITUTE
  		Employer identification number
52-1842938
Part I
Contributors
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
 
 
 
 
  ,    

$ RESTRICTED


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
Schedule B (Form 990, 990-EZ, or 990-PF) (2020)
Schedule B (Form 990, 990-EZ, or 990-PF) (2020)
Page 3
Name of organization
J CRAIG VENTER INSTITUTE
  		Employer identification number

52-1842938
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I		 (b)
Description of noncash property given		 (c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
Schedule B (Form 990, 990-EZ, or 990-PF) (2020)
Schedule B (Form 990, 990-EZ, or 990-PF) (2020)
Page 4
Name of organization
J CRAIG VENTER INSTITUTE
  		Employer identification number

52-1842938
Part III
Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
Schedule B (Form 990, 990-EZ, or 990-PF) (2020)
Additional Data


Software ID:  
Software Version:  
SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet Attach to Form 990.
SchDMd Bullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2020
Open to Public Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate value of contributions to (during year)    
3 Aggregate value of grants from (during year)    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ...................... 2a  
b Total acreage restricted by conservation easements .................... 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............
6
Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenue included on Form 990, Part VIII, line 1 .........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ...............................SchDMd Bullet $ 2,545,000
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:
a
Revenue included on Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2020

Schedule D (Form 990) 2020
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b If "Yes," explain the arrangement in Part XIII and complete the following table: Amount
c Beginning balance ............................. 1c  
d Additions during the year ............................ 1d  
e Distributions during the year .......................... 1e  
f Ending balance ................................ 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...
b
If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....
Part V
Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.
(a) Current year (b) Prior year (c) Two years back (d) Three years back (e) Four years back
1a Beginning of year balance ....          
b Contributions ...          
c Net investment earnings, gains, and losses          
d Grants or scholarships ...          
e Other expenditures for facilities
and programs ... 		         
f Administrative expenses ....          
g End of year balance ......          
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Term endowment SchDMd Bullet  
The percentages on lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) Unrelated organizations .......................
3a(i)
 
 
(ii) Related organizations .......................
3a(ii)
 
 
b
If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis
(investment) 		(b) Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .....      
b Buildings ....   53,875,009 10,050,198 43,824,811
c Leasehold improvements        
d Equipment ....   15,190,146 14,365,124 825,022
e Other .....        
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..SchDMdBullet 44,649,833
Schedule D (Form 990) 2020

Schedule D (Form 990) 2020
Page 3
Part VII
Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(1) Financial derivatives.........    
(2) Closely-held equity interests........    
(3)Other
(B)
(C)
(D)
(E)
(F)
(G)
(H)
(I)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet  
Part VIII
Investments - Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
(1) Federal income taxes  
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 5,077,885
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII
Schedule D (Form 990) 2020

Schedule D (Form 990) 2020
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ....... 1 20,221,044
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains (losses) on investments .... 2a 2,056,108
b Donated services and use of facilities ......... 2b 360,000
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d ..................... 2e 2,416,108
3 Subtract line 2e from line 1.................. 3 17,804,936
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a 108,379
b Other (Describe in Part XIII.) ........... 4b 15,294
c Add lines 4a and 4b.................... 4c 123,673
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5 17,928,609
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ........... 1 30,626,400
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities ......... 2a 360,000
b Prior year adjustments ............ 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d.................... 2e 360,000
3 Subtract line 2e from line 1................... 3 30,266,400
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a 108,379
b Other (Describe in Part XIII.) ............ 4b  
c Add lines 4a and 4b..................... 4c 108,379
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5 30,374,779
Part XIII
Supplemental Information
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Return Reference Explanation
PART III, LINE 4: COLLECTION OF SCIENTIFIC WRITINGS RELEVANT TO GENOMIC RESEARCH.
PART X, LINE 2: THE INSTITUTE IS A NOT-FOR-PROFIT ORGANIZATION EXEMPT FROM FEDERAL INCOME TAXES UNDER SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE. THE INSTITUTE DOES NOT BELIEVE THERE ARE ANY MATERIAL UNCERTAIN TAX POSITIONS AND ACCORDINGLY, NO PROVISION FOR INCOME TAXES HAS BEEN MADE IN THE ACCOMPANYING FINANCIAL STATEMENTS. THE INSTITUTE IS SUBJECT TO ROUTINE AUDITS BY TAXING JURISDICTIONS; HOWEVER, THERE ARE CURRENTLY NO AUDITS FOR ANY TAX PERIOD IN PROGRESS.
PART XI, LINE 4B - OTHER ADJUSTMENTS: K-1 PASSTHROUGH 15,294.
Schedule D (Form 990) 2020


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SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990.Right pointing arrow large image Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2020
Open to Public Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in the region (d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in the region		 (f) Total expenditures
for and investments
in the region
EAST ASIA AND THE PACIFIC - AUSTRALIA, BRUNEI, BURMA, CAMBODIA,     PROGRAM SERVICES RESEARCH SUBGRANTS 59,986
CAYMAN ISLANDS     INVESTMENTS   143,279
           
           
           
           
           
           
           
           
           
           
           
           
           
           
           
3a Sub-total .... 0 0 203,265
b Total from continuation sheets to Part I ... 0 0 0
c Totals (add lines 3a and 3b) 0 0 203,265
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2020
Schedule F (Form 990) 2020
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount
of noncash
assistance 		(h) Description
of noncash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
EAST ASIA AND THE PACIFIC PROGRAM SERVICES 59,986 WIRE      
             
             
             
             
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
1
3 Enter total number of other organizations or entities .......................MediumBullet
 
Schedule F (Form 990) 2020
Schedule F (Form 990) 2020Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
noncash
assistance 		(g) Description
of noncash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2020
Schedule F (Form 990) 2020
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2020
Schedule F (Form 990) 2020
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
ReturnReference Explanation
PART I, LINE 2: EACH SUBGRANT IS A PASS THROUGH GRANT FROM A FEDERAL OR NON-FEDERAL GRANT OR CONTRACT AWARDED TO J. CRAIG VENTER INSTITUTE. ALL EXPENSES ARE MONITORED AS INVOICED AT LEAST QUARTERLY, BUT IN MOST CASES MONTHLY. THE INVOICES ARE REVIEWED AND APPROVED BASED ON RECEIPT OF GOODS OR SERVICES AND AGAINST AN APPROVED BUDGET.
PART I, LINE 3: ACCRUAL BASIS
PART III ACCOUNTING METHOD:  
PART II, LINE 1: ACCRUAL BASIS
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2020
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Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990.
lBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2020
Open to Public
Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number
52-1842938
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient
that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government		 (b) EIN (c) IRC section
(if applicable)		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
noncash assistance		 (h) Purpose of grant
or assistance
(1) UNIVERSITY OF CALIFORNIA SAN DIEGO
9500 GILMAN DR
LA JOLLA,CA92037 		56-6001393 501(C)(3) 646,423       RESEARCH SUBGRANT
(2) UNIVERSITY OF CALIFORNIA IRVINE
120 THEORY SUITE 200
IRVINE,CA92697 		95-2226406 501(C)(3) 73,149       RESEARCH SUBGRANT
(3) COLORADO STATE UNIVERSITY
6015 CAMPUS DELIVERY
FORT COLLINS,CO80523 		84-6000545 501(C)(3) 441,120       RESEARCH SUBGRANT
(4) MRI GLOBAL
425 VOLKER BLVD
KANSAS CITY,MO641102241 		44-0545878 501(C)(3) 117,251       RESEARCH SUBGRANT
(5) REGENTS UNIVERSITY OF MINNESOTA
700 ROSEDALE AVE
ST LOUIS,MO63112 		43-0653611 501(C)(3) 46,643       RESEARCH SUBGRANT
(6) VANDERBILT UNIVERSITY
2201 WEST END AVE
NASHVILLE,TN37235 		62-0476822 501(C)(3) 236,730       RESEARCH SUBGRANT
(7) RHODE ISLAND HOSPITAL
1 HOPPIN STREET BOX 42 SUITE 1300
PROVIDENCE,RI029034923 		05-0258954 501(C)(3) 393,803       RESEARCH SUBGRANT
(8) SALK INSTITUTE
10010 N TORREY PINES ROAD
LA JOLLA,CA92037 		95-2160097 501(C)(3) 123,771       RESEARCH SUBGRANT
(9) SANTA FE INSTITUTE
1399 HYDE PARK ROAD
SANTA FE,NM875018943 		85-0325494 501(C)(3) 46,969       RESEARCH SUBGRANT
(10) SEQUELLA FOUNDATION INC
9610 MEDICAL CENTER DRIVE 200
ROCKVILLE,MD20850 		52-2044703 501(C)(3) 5,378       RESEARCH SUBGRANT
(11) LELAND STANFORD JR UNIVERSITY
3145 PORTER DRIVE
PALO ALTO,CA94304 		94-1156365 501(C)(3) 254,611       RESEARCH SUBGRANT
(12) CAL POLY CORPORATION
1 GRAND AVE
SAN LUIS OBSISPO,CA93407 		95-1648180 501(C)(3) 30,426       RESEARCH SUBGRANT
(13) GLOBAL ALGAE INNOVATIONS
486 LIVE OAK DRIVE
EL CAJON,CA92020 		45-5319556   326,567       RESEARCH SUBGRANT
(14) LAWRENCE LIVERMORE NATIONAL LABORATORY
7000 EAST AVE
LIVERMORE,CA94550 		20-5624386 GOVT 40,000       RESEARCH SUBGRANT
2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image
13
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
1
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2020

Schedule I (Form 990) 2020
Page 2
Part III
Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Number of
recipients		 (c) Amount of
cash grant		 (d) Amount of
noncash assistance		 (e) Method of valuation (book,
FMV, appraisal, other)		 (f) Description of noncash assistance
(1)
(2)
(3)
(4)
(5)
(6)
(7)
Part IV
Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.
Return Reference Explanation
PART I, LINE 2: EACH SUBGRANT IS A PASS THROUGH GRANT FROM A FEDERAL OR NON-FEDERAL GRANT OR CONTRACT AWARDED TO J. CRAIG VENTER INSTITUTE. ALL EXPENSES ARE MONITORED AS INVOICED AT LEAST QUARTERLY, BUT IN MOST CASES MONTHLY. THE INVOICES ARE REVIEWED AND APPROVED BASED ON RECEIPT OF GOODS OR SERVICES AND AGAINST AN APPROVED BUDGET.
Schedule I (Form 990) 2020



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Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
Graphic Arrow Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
Graphic Arrow Attach to Form 990.
Graphic Arrow Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2020
Open to Public Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .....
1b
Yes
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ....
2
Yes
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? .............
4a
 
No
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
 
No
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.
5
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ....................
5a
 
No
b
Any related organization? .......................
5b
 
No
If "Yes," on line 5a or 5b, describe in Part III.
6
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ..................
6a
 
No
b
Any related organization? ......................
6b
 
No
If "Yes," on line 6a or 6b, describe in Part III.
7
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
 
No
8
Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................
8
 
No
9
If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2020

Schedule J (Form 990) 2020
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2 and/or 1099-MISC compensation (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation in column (B) reported as deferred on prior Form 990
(i) Base
compensation 		(ii) Bonus & incentive
compensation 		(iii) Other reportable compensation
1VENTER JOHN CRAIG
CHAIRMAN & CEO 		(i)

(ii)		 1,178,618
-------------
0 		0
-------------
0 		15,717
-------------
0 		11,400
-------------
0 		33,900
-------------
0 		1,239,635
-------------
0 		0
-------------
0
2NELSON KAREN
PRESIDENT 		(i)

(ii)		 705,214
-------------
0 		0
-------------
0 		5,787
-------------
0 		11,400
-------------
0 		50,132
-------------
0 		772,533
-------------
0 		0
-------------
0
3KOWALSKI HEATHER
CHIEF OPERATING OFFICER 		(i)

(ii)		 446,179
-------------
0 		0
-------------
0 		3,142
-------------
0 		11,400
-------------
0 		25,338
-------------
0 		486,059
-------------
0 		0
-------------
0
4MULLEN JILL
SR. VP OF PHILANTHROPY AND STRATEGIC 		(i)

(ii)		 342,958
-------------
0 		0
-------------
0 		7,102
-------------
0 		11,400
-------------
0 		51,609
-------------
0 		413,069
-------------
0 		0
-------------
0
5SCHEUERMANN RICHARD H
DIRECTOR, LA JOLLA CAMPUS 		(i)

(ii)		 340,418
-------------
0 		0
-------------
0 		8,409
-------------
0 		11,400
-------------
0 		45,059
-------------
0 		405,286
-------------
0 		0
-------------
0
6STOUT MARTIN
CHIEF TECHNOLOGY OFFICER 		(i)

(ii)		 299,769
-------------
0 		0
-------------
0 		8,402
-------------
0 		11,400
-------------
0 		24,827
-------------
0 		344,398
-------------
0 		0
-------------
0
7PEAKE ANTONY G
VP FOR RESEARCH ADMINISTRATION 		(i)

(ii)		 291,936
-------------
0 		0
-------------
0 		2,587
-------------
0 		11,400
-------------
0 		19,233
-------------
0 		325,156
-------------
0 		0
-------------
0
8YUMULMARY
VP OF HUMAN RESOURCES 		(i)

(ii)		 250,697
-------------
0 		0
-------------
0 		2,532
-------------
0 		10,400
-------------
0 		54,998
-------------
0 		318,627
-------------
0 		0
-------------
0
9KIRKNESS EWEN
PROFESSOR 		(i)

(ii)		 256,212
-------------
0 		0
-------------
0 		822
-------------
0 		10,400
-------------
0 		44,354
-------------
0 		311,788
-------------
0 		0
-------------
0
10STAYEAS TIMOTHY
NETWORK TEAM LEAD 		(i)

(ii)		 212,920
-------------
0 		0
-------------
0 		1,520
-------------
0 		8,986
-------------
0 		51,485
-------------
0 		274,911
-------------
0 		0
-------------
0
11ADELSON JULIE
VP, LEG. AFFRS/GENERAL COUNSEL 		(i)

(ii)		 197,625
-------------
0 		0
-------------
0 		12,526
-------------
0 		8,015
-------------
0 		28,750
-------------
0 		246,916
-------------
0 		0
-------------
0
12PRATTE EDWARD
DIRECTOR OF SECURITY 		(i)

(ii)		 223,817
-------------
0 		0
-------------
0 		2,878
-------------
0 		0
-------------
0 		7,187
-------------
0 		233,882
-------------
0 		0
-------------
0
13FRIEDMAN ROBERT M
VP FOR POLICY & UNIV. RELATIONS 		(i)

(ii)		 126,606
-------------
0 		0
-------------
0 		16,576
-------------
0 		5,305
-------------
0 		47,361
-------------
0 		195,848
-------------
0 		0
-------------
0
Schedule J (Form 990) 2020

Schedule J (Form 990) 2020
Page 3
Part III
Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.
Return Reference Explanation
PART I, LINE 1A SCHEDULE J, PART I, LINE 1A: TAX INDEMIFICATION AND GROSS-UP PAYMENTS - CERTAIN AWARDS ARE GROSSED UP FOR INCOME TAX AND INCLUDED AS TAXABLE COMPENSATION. SCHEDULE J, PART I, LINE 1A; FIRST-CLASS OR CHARTER TRAVEL - THE ORGANIZATION PROVIDES THE CEO FIRST CLASS AND CHARTER TRAVEL FOR BUSINESS PURPOSES. NO PART OF THIS BENEFIT IS TREATED AS TAXABLE COMPENSATION. SCHEDULE J, PART I, LINE 1A; PERSONAL SERVICES - THE ORGANIZATION PROVIDES THE CEO SERVICES OF BODYGUARDS WHEN HE TRAVELS. NO PART OF THIS BENEFIT IS TREATED AS TAXABLE COMPENSATION.
Schedule J (Form 990) 2020

Additional Data


Software ID:  
Software Version:  
SCHEDULE O
(Form 990 or 990-EZ)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
MediumBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2020
Open to Public
Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Return Reference Explanation
FORM 990, PART III, LINE 4A, PROGRAM SERVICE ACCOMPLISHMENTS (CONTINUED): THE GAPS IN KNOWLEDGE WE AIM TO BRIDGE ARE TO DEFINE AND CHARACTERIZE NOVEL PNEUMOCOCCAL ANTIGENIC PROTEINS AND POLYELECTROLYTE ADJUVANTS FORMULATIONS THAT WILL INITIATE ADAPTIVE IMMUNE RESPONSES AND LEAD TO PROTECTION AGAINST DISEASE IN A SEROTYPE INDEPENDENT MANNER. THE PROPOSED WORK IS SIGNIFICANT DUE TO THE HIGH INCIDENCE SEROTYPE REPLACEMENT THAT CURRENT POLYSACCHARIDE-BASED VACCINES ARE PRONE TO, WHICH LEADS TO INCREASE SUSCEPTIBILITY OF CHILDREN AND THE ELDERLY TO SPN CARRIAGE AND SEVERE INFECTIONS (E.G., PNEUMONIA, BACTEREMIA, AND MENINGITIS); AND INNOVATIVE SINCE IT WILL USE NOVEL FORMULATIONS OF ANTIGENIC AND CONSERVED PNEUMOCOCCAL PROTEINS TO INDUCE POTENT ADAPTIVE IMMUNE RESPONSES, THAT WILL NOT BE SEROTYPE DEPENDENT. FUNDED THROUGH THE NATIONAL INSTITUTE OF ALLERGY AND IMMUNOLOGY (NIAID/NIH) INTERPLAY BETWEEN THE HEAT SHOCK RESPONSE AND HISTIDINE KINASE PATHWAYS IN THE THERMALLY DIMORPHIC FUNGAL PATHOGEN HISTOPLASMA CAPSULATUM. HISTOPLASMA CAPSULATUM IS ONE OF SEVERAL SYSTEMIC DIMORPHIC FUNGAL PATHOGENS THAT SWITCH THEIR GROWTH PROGRAM FROM AN INFECTIOUS MOLD FORM IN THE SOIL TO A PATHOGENIC YEAST FORM IN MAMMALIAN HOSTS. H. CAPSULATUM CAUSES UP TO 25,000 LIFE-THREATENING INFECTIONS PER YEAR IN THE U.S. ALONE WITH UP TO 50% MORTALITY RATE AND IS THE MOST COMMON CAUSE OF FUNGAL RESPIRATORY INFECTIONS IN HEALTHY HOSTS. INFECTION OCCURS WHEN THE SOIL IS DISRUPTED, FACILITATING DISPERSION OF HYPHAL FRAGMENTS OR SPORES THAT ARE INHALED BY HUMANS. SPORES AND HYPHAL FRAGMENTS ARE THE PRIMARY INFECTIOUS AGENTS; HOWEVER, ONCE INTRODUCED INTO THE HOST, THE PATHOGEN CONVERTS TO A BUDDING-YEAST FORM, WHICH SURVIVES AND REPLICATES WITHIN HOST MACROPHAGES. HUMAN BODY TEMPERATURE IS THE PRIMARY SIGNAL FOR CONVERSION FROM AN INFECTIOUS TO A PARASITIC FORM IN HISTOPLASMA. DESPITE ITS IMPORTANCE TO HUMAN HEALTH, VERY LITTLE IS KNOWN ABOUT HOW H. CAPSULATUM SENSES AND RESPONDS TO HUMAN BODY TEMPERATURE. THE JCVI IN OUR FUNDED NIH R01 PROJECT, HAS PROPOSED TO BUILD UPON ITS PREVIOUS FINDINGS AND FULLY CHARACTERIZE THE INVOLVEMENT OF THE HEAT SHOCK RESPONSE AND HISTIDINE KINASE PATHWAYS IN REGULATING CELL MORPHOLOGY AND VIRULENCE TRAITS IN H. CAPSULATUM IN RESPONSE TO HOST TEMPERATURE. JCVI HAS BEEN WORKING ON IMPROVING H. CAPSULATUM GENOME ASSEMBLY. TO THIS END, IT USED LONG-READ SEQUENCING TECHNOLOGY AND SUCCESSFULLY COMPLETED CHROMOSOMAL LEVEL ASSEMBLIES OF FIVE COMMONLY USED HISTOPLASMA STRAINS, WHICH HAVE SIX OR SEVEN CHROMOSOMES. JCVI DESCRIBED ITS FINDINGS IN A MANUSCRIPT THAT IS CURRENTLY UNDER REVISION AT THE MBIO JOURNAL. JCVI WILL BE UTILIZING ITS NEW ASSEMBLIES AND ANNOTATIONS IN THE TRANSCRIPTOME STUDIES THAT IT HAS BEEN PERFORMING WITHIN THE SCOPE OF OUR FUNDED PROJECT. RESULTS OF THIS PROJECT WILL PROVIDE FUNDAMENTAL INFORMATION ON HOW CELLS SENSE TEMPERATURE AND TURN ON THE APPROPRIATE VIRULENCE PATHWAYS IN THE HOST. ULTIMATELY, THE INFORMATION OBTAINED FROM THIS PROJECT CAN BE USED TO DEVELOP THERAPEUTICS FOR H. CAPSULATUM INFECTIONS AND HELP PREVENT OTHER DIMORPHIC FUNGAL INFECTIONS. GREATER THAN 10% OF HIV PATIENTS INJECT ILLICIT DRUGS AND WITH THE RISING OPIOID CRISIS AND THE INCREASED RISK OF HIV IN THESE PATIENTS, IT IS CRITICAL WE UNDERSTAND HOW SUBSTANCE USE INFLUENCES THE SPREAD AND COURSE OF HIV INFECTION AND DISEASE. FUNDED BY THE NATIONAL INSTITUTE OF DRUG ABUSE (NIDA/NIH) AND IN COLLABORATION WITH BOSTON UNIVERSITY, THIS STUDY SPECIFICALLY ADDRESSES HOW OPIOID ABUSE ALTERS THE IMMUNE RESPONSE IN HIV PATIENTS AND WITH THIS CAN DIRECTLY CONTRIBUTE TO HIDDEN RESERVOIRS OF HIV. SUCCESSFUL COMPLETION OF THESE STUDIES WILL PROVIDE INSIGHTS INTO POTENTIAL STRATEGIES FOR TREATING HIV IN THIS GROWING POPULATION OF HIV PATIENTS. OUR CENTRAL HYPOTHESIS IS THAT OPIOID MISUSE EXACERBATES HIV PATHOGENESIS AND THE ESTABLISHMENT OF HIV LATENCY BY DYSREGULATING THE HOST IMMUNE RESPONSE. OUR OVERALL OBJECTIVE IS TO EXPLOIT TRANSCRIPTOMIC INFORMATION FROM PATIENT SAMPLES TO CHARACTERIZE THE EFFECTS OF OPIOID USE DISORDER ON HOST IMMUNE FUNCTION, HIV REPLICATION, AND HIV LATENCY. WE WILL CHARACTERIZE SINGLE CELL GENE EXPRESSION AND IDENTIFY DYSREGULATED GENE REGULATORY NETWORKS IN IMMUNE CELLS ASSOCIATED WITH OPIOID MISUSE IN PLWH. WE WILL ALSO PERFORM COMPUTATIONAL ANALYSIS TO IDENTIFY IMMUNE CELL GENE REGULATORY NETWORKS ALTERED BY OPIOID MISUSE AND WE WILL COMBINE SINGLE CELL RNA-SEQ AND FLUORESCENT IN SITU HYBRIDIZATION FLOW CYTOMETRY (FLOW-FISH) TO CHARACTERIZE THE TRANSCRIPTOME IN CELL MODELS OF LATENT HIV INFECTION. SUCCESSFUL COMPLETION OF THESE AIMS WILL HAVE SIGNIFICANT RESEARCH AND CLINICAL IMPACT BY: 1) ELUCIDATING HOW OPIOID MISUSE ALTERS HIV PATHOGENESIS; 2) PRODUCING NOVEL TOOLS FOR CHARACTERIZING HIV LATENCY; AND 3) DISCOVERING CANDIDATE MOLECULES TO REGULATE HIV EXPRESSION IN THE CONTEXT OF OPIOID MISUSE. SEVERAL ADDITIONAL DHHS GRANTS AT JCVI ARE RELATED TO HUMAN MICROBIOME STUDIES. THE MICROBIOME IS THE COLLECTION OF MICROBES THAT LIVE IN AND ON THE HUMAN BODY; THESE SPECIES HAVE RECEIVED CONSIDERABLE ATTENTION IN RECENT YEARS BECAUSE A NEW APPRECIATION OF THE COMPLEX ROLES THAT THEY PLAY IN HEALTH AND DISEASE. SOME OF THESE STUDIES ARE AIMED AT BASIC CHARACTERIZATION OF THE COMPOSITION AND ACTIVITY OF THE MICROBIOME, WHILE OTHERS SEEK TO UNDERSTAND THE CONTRIBUTION OF THE MICROBIOME TO THE DEVELOPMENT OF VARIOUS DISEASES INCLUDING ALCOHOLIC HEPATITIS, TYPE 1 DIABETES, DENTAL CARIES, DIARRHEA, AND ESOPHAGEAL CANCER, AMONG OTHERS. THE INSTITUTE IS AN ACTIVE PARTICIPATANT IN THE H3AFRICA PROGRAM VIA A COLLABORATION WITH THE UNIVERSITY OF CAPE TOWN, SOUTH AFRICA, TRAINING COLLABORATORS IN HUMAN MICROBIOME ANALYSIS. THE PROGRAM IS SPONSORED BY THE NIH COMMON FUND TO BRING TECHNOLOGICAL RESOURCES AND TRAINING IN A CAPITAL INVESTMENT-INTENSIVE FIELD (GENOMICS) TO THE AFRICAN CONTINENT VIA COLLABORATIONS WITH US SCIENTISTS WITH EXPERTISE IN THIS FIELD.
FORM 990, PART VI, SECTION A, LINE 2 BOARD MEMBERS HEATHER KOWALSKI AND J. CRAIG VENTER HAVE A FAMILY RELATIONSHIP.
FORM 990, PART VI, SECTION B, LINE 11B THE FORM 990 IS REVIEWED BY MANAGEMENT. A COMPLETE COPY OF THE FORM 990 AND SUPPORTING SCHEDULES WAS PROVIDED TO THE FULL BOARD FOR REVIEW PRIOR TO BEING FILED.
FORM 990, PART VI, SECTION B, LINE 12C JCVI MONITORS COMPLIANCE OF ITS CONFLICT OF INTEREST POLICY THROUGH AN ANNUAL SOLICITATION OF CONFLICT OF INTEREST STATEMENTS FROM TRUSTEES, OFFICERS, AND EMPLOYEES. IF A PERSON HAS A CONFLICT WITH RESPECT TO A TRANSACTION, SUCH PERSON IS NOT ALLOWED TO VOTE.
FORM 990, PART VI, SECTION B, LINE 15 JCVI USES AN OUTSIDE COMPENSATION CONSULTANT, TO PROVIDE A LIST OF COMPARABLE SALARIES FOR THE CEO AND OFFICERS THESE ARE REVIEWED BY THE JCVI COMPENSATION COMMITTEE AND CEO BEFORE A FINAL DETERMINATION IS MADE. THIS PROCESS WAS DOCUMENTED AND LAST DONE IN OCTOBER 2018.
FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION'S FINANCIAL STATEMENTS, GOVERNING DOCUMENTS, AND CONFLICT OF INTEREST POLICY ARE MADE AVAILABLE TO THE PUBLIC UPON REQUEST.
FORM 990, PART XI, LINE 9: K-1 PASSTHROUGH -15,294.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990 or 990-EZ) 2020


Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBulletAttach to Form 990.
MediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047
2020
Open to Public Inspection
Name of the organization
J CRAIG VENTER INSTITUTE
 
Employer identification number

52-1842938
Part I
Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income


 		(e)
End-of-year assets


 		(f)
Direct controlling
entity










Part II
Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section


 		(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled entity?
Yes No












For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2020
Schedule R (Form 990) 2020
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related organizations treated as a partnership during the tax year.
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V-UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No












Part IV
Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.
(a)
Name, address, and EIN of
related organization
 		(b)
Primary activity
 		(c)
Legal
domicile
(state or foreign
country)
 		(d)
Direct controlling
entity
 		(e)
Type of entity
(C corp, S corp,
or trust) 		(f)
Share of total income
 		(g)
Share of end-of-year
assets
 		(h)
Percentage
ownership
 		(i)
Section 512(b)(13) controlled entity?
Yes No
(1) J CRAIG VENTER INSTITUTE MEDICAL GROUP

4120 CAPRICORN LANE
LA JOLLA,CA92037
83-3574850 		MEDICAL OFFICE CA N/A
 C     100.000 % Yes  












Schedule R (Form 990) 2020
Schedule R (Form 990) 2020
Page 3
Part V
Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................
1a
 
No
b Gift, grant, or capital contribution to related organization(s) ............................
1b
 
No
c Gift, grant, or capital contribution from related organization(s) ............................
1c
 
No
d Loans or loan guarantees to or for related organization(s) ............................
1d
 
No
e Loans or loan guarantees by related organization(s) ............................
1e
 
No
f Dividends from related organization(s) ............................
1f
 
No
g Sale of assets to related organization(s) ............................
1g
 
No
h Purchase of assets from related organization(s) ............................
1h
 
No
i Exchange of assets with related organization(s) ............................
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) .......................
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) ......................
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) .....................
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) .................
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................
1n
 
No
o Sharing of paid employees with related organization(s) ............................
1o
 
No
p Reimbursement paid to related organization(s) for expenses ............................
1p
 
No
q Reimbursement paid by related organization(s) for expenses ............................
1q
 
No
r Other transfer of cash or property to related organization(s) ............................
1r
Yes
 
s Other transfer of cash or property from related organization(s) ............................
1s
 
No
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of related organization 		(b)
Transaction
type (a-s) 		(c)
Amount involved 		(d)
Method of determining amount involved





Schedule R (Form 990) 2020
Schedule R (Form 990) 2020
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income (related, unrelated, excluded from tax under sections 512-514)

(e)
Are all partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V-UBI
amount in box 20
of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2020
Schedule R (Form 990) 2020
Page 5
Part VII
Supplemental Information
Provide additional information for responses to questions on Schedule R. See instructions.
Return Reference Explanation
Schedule R (Form 990) 2020

Additional Data


Software ID:  
Software Version: