TY 2021 Form 990

- TIN:

Form990

Department of the TreasuryInternal Revenue Service

Return of Organization Exempt From Income Tax

Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)

Do not enter social security numbers on this form as it may be made public.

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

A For the 2021 calendar year, or tax year beginning 01-01-2021 , and ending 12-31-2021

BCheck if applicable: Address change Name change Initial return Final return/terminated Amended return Application pending

CName of organization
NEW YORK GENOME CENTER INC

Doing business as

Number and street (or P.O. box if mail is not delivered to street address)
101 AVENUE OF THE AMERICAS 7TH FL

Room/suite

City or town, state or province, country, and ZIP or foreign postal code
NEW YORK, NY10013

D Employer identification number

80-0631734

E Telephone number

G Gross receipts $ 75,770,198

F Name and address of principal officer:
TOM MANIATIS
101 AVE OF THE AMERICAS
NEW YORK,NY10013

Tax-exempt status: 501(c)(3) 501(c) ( ) LeftBullet

(insert no.) 4947(a)(1) or 527

Website:

WWW.NYGENOME.ORG

H(a)

Is this a group return for
subordinates? Yes No

H(b)

Are all subordinates
included?

Yes No

If "No," attach a list. See instructions.

H(c)

Group exemption number MediumBullet

K Form of organization: Corporation Trust Association Other MediumBullet

L Year of formation: 2010

M State of legal domicile: DE

Part I

Summary

1	Briefly describe the organization’s mission or most significant activities: ADVANCING GENOMIC RESEARCH TO DRIVE NOVEL BIOMEDICAL DISCOVERIES TO IMPROVE HUMAN HEALTH.
2	Check this box
3	Number of voting members of the governing body (Part VI, line 1a) ........	3	23
4	Number of independent voting members of the governing body (Part VI, line 1b) .....	4	22
5	Total number of individuals employed in calendar year 2021 (Part V, line 2a) ......	5	226
6	Total number of volunteers (estimate if necessary) .............	6	22
7a	Total unrelated business revenue from Part VIII, column (C), line 12 ........	7a	1,994,450
b	Net unrelated business taxable income from Form 990-T, Part I, line 11 .........	7b	0

		Prior Year	Current Year
8	Contributions and grants (Part VIII, line 1h) .........	51,639,109	61,556,925
9	Program service revenue (Part VIII, line 2g) .........	8,497,659	9,002,608
10	Investment income (Part VIII, column (A), lines 3, 4, and 7d ) ....	90,496	27,107
11	Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e)	556,725	1,712,471
12	Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)	60,783,989	72,299,111
13	Grants and similar amounts paid (Part IX, column (A), lines 1–3 )...	1,010,263	1,760,070
14	Benefits paid to or for members (Part IX, column (A), line 4).....	0	0
15	Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10)	28,728,885	27,400,508
16a	Professional fundraising fees (Part IX, column (A), line 11e) .....	2,325	250
b	Total fundraising expenses (Part IX, column (D), line 25) 453,549
17	Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e)....	42,564,807	39,947,593
18	Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25)	72,306,280	69,108,421
19	Revenue less expenses. Subtract line 18 from line 12.......	-11,522,291	3,190,690
		Beginning of Current Year	End of Year
20	Total assets (Part X, line 16).............	83,547,232	85,222,125
21	Total liabilities (Part X, line 26).............	47,595,266	46,079,469
22	Net assets or fund balances. Subtract line 21 from line 20.....	35,951,966	39,142,656

Part II

Signature Block

Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.

Sign Here

	Signature of officer	Date

	Type or print name and title

Paid Preparer Use Only

Print/Type preparer's name

Preparer's signature

Date

Check if
self-employed

PTIN

Firm's name MediumBullet

Firm's EIN MediumBullet

Firm's address MediumBullet

Phone no.

May the IRS discuss this return with the preparer shown above? (see instructions) ..........YesNo

For Paperwork Reduction Act Notice, see the separate instructions.

Cat. No. 11282Y Form 990 (2021)

Form 990 (2021)

Page 2

Part III

Statement of Program Service Accomplishments

Check if Schedule O contains a response or note to any line in this Part III..............

Briefly describe the organization’s mission: OPERATE A STATE-OF-THE-ART, WORLD CLASS GENOMIC RESEARCH CENTER THAT CREATES AND USES ADVANCED GENOMICS TO UNDERSTAND THE GENETIC BASIS OF DISEASE. FOR MORE INFORMATION, SEE SCHEDULE O.

Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ..................... Yes No

If "Yes," describe these new services on Schedule O.

Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ........................... Yes No

If "Yes," describe these changes on Schedule O.

Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.


4a	(Code: ) (Expenses $ 51,412,857 including grants of $ 1,760,070 ) (Revenue $ 7,531,190 )
	RESEARCH AND RESEARCH SEQUENCING: NYGC'S RESEARCH SCIENTISTS AND FACULTY CONDUCT RESEARCH INTO THE GENETIC FACTORS THAT CONTRIBUTE TO HUMAN DISEASE, BOTH IN THEIR OWN PROJECTS AND THROUGH COLLABORATIONS. NYGC RESEARCHERS HAVE PROJECTS UNDERWAY IN CANCER, INCLUDING LUNG, LIVER, BREAST AND MELANOMA, A MULTISITE VERY RARE CANCER PROJECT AND A LARGE COLLABORATIVE PROJECT STUDYING CANCER IN UNDERSERVED POPULATIONS IN NYC; NEURODEGENERATIVE DISEASES, INCLUDING ALS AND DEMENTIA AND NEUROPSYCHIATRIC DISEASES, FOCUSING ON AUTISM, AMONG OTHERS. IN 2021, NYGC SEQUENCED OVER 4,500 WHOLE GENOME SAMPLES, AS WELL AS NEARLY 6,000 COVID VIRAL SAMPLES, COMPLETED 611 PROJECTS, AND COLLABORATED WITH 101 INVESTIGATORS FROM 52 INSTITUTIONS WORLDWIDE. FOR MORE INFORMATION SEE SCHEDULE O.

4b	(Code: ) (Expenses $ 4,420,664 including grants of $ ) (Revenue $ 1,471,418 )
	CLINICAL SEQUENCING: NYGC IS AUTHORIZED BY THE NEW YORK STATE DEPARTMENT OF HEALTH TO OFFER THE FOLLOWING APPROVED CLINICAL TESTS THROUGH ITS CLEP/CLIA CERTIFIED CLINICAL LABORATORY: CONSTITUTIONAL WHOLE GENOME SEQUENCING FOR UNDIAGNOSED DISEASE, CONSTITUTIONAL WHOLEGENOME SEQUENCING FOR PREDISPOSITIONAL GENETIC SCREENING, ONCOLOGY WHOLE GENOME AND TRANSCRIPTOME SEQUENCING, CONSTITUTIONAL WHOLE EXOME SEQUENCING, TARGETED VARIANT TESTING USING SANGER SEQUENCING, ONCOLOGY WHOLE EXOME AND TRANSCRIPTOME SEQUENCING, AND THE SMASH GENOMIC ASSAY.

4c	(Code: ) (Expenses $ including grants of $ ) (Revenue $ )












4d	Other program services (Describe in Schedule O.)
	(Expenses $ including grants of $ ) (Revenue $ )
4e	Total program service expenses55,833,521

Form 990 (2021)

Page 3

Part IV

Checklist of Required Schedules

Yes

Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule A Click to see attachment

.....................

Yes

Is the organization required to complete Schedule B, Schedule of Contributors? See instructions. Click to see attachment

...

Yes

Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part I Click to see attachment

.............

Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part II Click to see attachment

.........

Yes

Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Rev. Proc. 98-19? If "Yes," complete Schedule C, Part III Click to see attachment

Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part I Click to see attachment

.........................

Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part II Click to see attachment

....

Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes,"
complete Schedule D, Part III Click to see attachment

..............

Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IV Click to see attachment

..............

Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi endowments? If "Yes," complete Schedule D, Part V......

If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X, as applicable.

Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete
Schedule D, Part VI. Click to see attachment

...................

11a

Yes

Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VII Click to see attachment

.......

11b

Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIII Click to see attachment

.......

11c

Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IX Click to see attachment

............

11d

Yes

Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part X Click to see attachment

11e

Yes

Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part X Click to see attachment

11f

Yes

12a

Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XII Click to see attachment

......................

12a

Yes

Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment

12b

Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E

14a

Did the organization maintain an office, employees, or agents outside of the United States? .....

14a

Yes

Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV......... Click to see attachment

14b

Yes

Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV..... Click to see attachment

Yes

Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV... Click to see attachment

Yes

Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I. See instructions. ....

Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............

Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................

20a

Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....

20a

If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?

20b

Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II..... Click to see attachment

Yes

Form 990 (2021)

Page 4

Part IV

Checklist of Required Schedules (continued)

Yes

Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........ Click to see attachment

Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5, about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment

Yes

24a

Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a...............

24a

Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...

24b

Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............

24c

Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...

24d

25a

Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I .... Click to see attachment

25a

Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I....................... Click to see attachment

25b

Did the organization report any amount on Part X, line 5 or 22 for receivables from or payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II Click to see attachment

...........

Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or employee thereof, a grant selection committee member, or to a 35% controlled entity (including an employee thereof) or family member of any of these persons?

If "Yes," complete

Schedule L, Part III Click to see attachment

.........................

Was the organization a party to a business transaction with one of the following parties (see the Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):

A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If "Yes," complete Schedule L, Part IV...................... Click to see attachment

28a

A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV..... Click to see attachment

28b

Yes

A 35% controlled entity of one or more individuals and/or organizations described in line 28a or 28b? If "Yes," complete Schedule L, Part IV.....................

28c

Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M.. Click to see attachment

Yes

Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M ................. Click to see attachment

Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I

Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II........................

Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I............

Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1.........................

35a

Did the organization have a controlled entity within the meaning of section 512(b)(13)?

35a

If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ...

35b

Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2.............

Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VI

Did the organization complete Schedule O and provide explanations on Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............

Yes

Part V

Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........

Yes

Enter the number reported in box 3 of Form 1096. Enter -0- if not applicable ..

Enter the number of Forms W-2G included on line 1a. Enter -0- if not applicable .

Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................

Yes

Form 990 (2021)

Page 5

Part V

Statements Regarding Other IRS Filings and Tax Compliance (continued)

Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................

226

If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file. See instructions.

Yes

Did the organization have unrelated business gross income of $1,000 or more during the year?...

Yes

If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...

Yes

At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..

If "Yes," enter the name of the foreign country: MediumBullet

See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).

Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..

Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?

If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............

Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...

If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................

Organizations that may receive deductible contributions under section 170(c).

Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................

If "Yes," did the organization notify the donor of the value of the goods or services provided? .....

Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................

If "Yes," indicate the number of Forms 8282 filed during the year ....

Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?

Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..

If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................

If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................

Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? ........

Sponsoring organizations maintaining donor advised funds.

Did the sponsoring organization make any taxable distributions under section 4966?........

Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...

Section 501(c)(7) organizations. Enter:

Initiation fees and capital contributions included on Part VIII, line 12 ...

10a

Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities

10b

Section 501(c)(12) organizations. Enter:

Gross income from members or shareholders .........

11a

Gross income from other sources. (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........

11b

12a

Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?

12a

If "Yes," enter the amount of tax-exempt interest received or accrued during the year.

12b

Section 501(c)(29) qualified nonprofit health insurance issuers.

Is the organization licensed to issue qualified health plans in more than one state? .........
Note. See the instructions for additional information the organization must report on Schedule O.

13a

Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....

13b

Enter the amount of reserves on hand ............

13c

14a

Did the organization receive any payments for indoor tanning services during the tax year?.....

14a

If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..

14b

Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or excess parachute payment(s) during the year? ....................
If "Yes," see the instructions and file Form 4720, Schedule N.

Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ..
If "Yes," complete Form 4720, Schedule O.

Section 501(c)(21) organizations. Did the trust, any disqualified person, or mine operator engage in any activities that would result in the imposition of an excise tax under section 4951, 4952, or 4953? ..
If "Yes," complete Form 6069.

Form 990 (2021)

Page 6

Part VI

Governance, Management, and Disclosure. For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.

Check if Schedule O contains a response or note to any line in this Part VI..............

Section A. Governing Body and Management

Yes

Enter the number of voting members of the governing body at the end of the tax year

If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.

Enter the number of voting members included in line 1a, above, who are independent

Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................

Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .

Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? .

Did the organization become aware during the year of a significant diversion of the organization’s assets? .

Did the organization have members or stockholders? ................

Yes

Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................

Yes

Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................

Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:

The governing body? .......................

Yes

Each committee with authority to act on behalf of the governing body? ............

Yes

Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......

Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)

Yes

10a

Did the organization have local chapters, branches, or affiliates? ............

10a

If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?

10b

11a

Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................

11a

Yes

Describe on Schedule O the process, if any, used by the organization to review this Form 990. .....

12a

Did the organization have a written conflict of interest policy? If "No," go to line 13.......

12a

Yes

Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................

12b

Yes

Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe on Schedule O how this was done...................

12c

Yes

Did the organization have a written whistleblower policy? ...............

Yes

Did the organization have a written document retention and destruction policy? .........

Yes

Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?

The organization’s CEO, Executive Director, or top management official ...........

15a

Yes

Other officers or key employees of the organization ................

15b

Yes

If "Yes" to line 15a or 15b, describe the process on Schedule O. See instructions.

16a

Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................

16a

If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............

16b

Section C. Disclosure

List the states with which a copy of this Form 990 is required to be filed MediumBullet

AL , AK , AR , CA , CO , CT , FL , GA , HI , IL , KS , KY , LA , ME , MD , MA , MI , MN , MS , MO , NH , NJ , NM , NY , NC , ND , OH , OK , OR , PA , RI , SC , TN , UT , VA , WA , WV , WI

Section 6104 requires an organization to make its Form 1023 (1024 or 1024-A, if applicable), 990, and 990-T (section 501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.

Own website Another's website Upon request Other (explain in Schedule O)

Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.

State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBullet

NANCY KONG101 AVENUE OF THE AMERICAS 7TH FL NEW YORK,NY10013 (646) 977-7154

Form 990 (2021)

Page 7

Part VII

Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors

Check if Schedule O contains a response or note to any line in this Part VII..............

Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees

1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet

List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

List all of the organization’s current key employees, if any. See the instructions for definition of "key employee."

List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (box 5 of Form W-2, Form 1099-MISC, and/or box 1 of Form 1099-NEC) of more than $100,000 from the
organization and any related organizations.

List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

See the instructions for the order in which to list the persons above.

Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)		(D) Reportable compensation from the organization (W-2/1099-MISC/1099-NEC)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)	(F) Estimated amount of other compensation from the organization and related organizations
(A) Name and title
(1) CHERYL A MOORE...................................................................... PRESIDENT & COO (THROUGH 3/21)	40.00 .................	X	X	628,607	0	18,267
(2) TOM MANIATIS PHD...................................................................... SCIENTIFIC DIRECTOR & CEO	40.00 .................	X	X	616,411	0	0
(3) DAFNA BAR-SAGI PHD...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(4) RUSSELL L CARSON MBA...................................................................... DIRECTOR & CO-CHAIR	4.00 .................	X	X	0	0	0
(5) ELI CASDIN...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(6) DENNIS S CHARNEY MD...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(7) AUGUSTINE MK CHOI MD...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(8) KENNETH A DILL PHD...................................................................... DIRECTOR (AS OF 6/21)	1.00 .................	X		0	0	0
(9) NICHOLAS DONOFRIO...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(10) JOSEPH E EDELMAN...................................................................... DIRECTOR (AS OF 6/21)	1.00 .................	X		0	0	0
(11) JOHN B EHRENKRANZ...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(12) ANTHONY B EVNIN PHD...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(13) JOHN P HAVENS...................................................................... DIRECTOR (AS OF 11/21)	1.00 .................	X		0	0	0
(14) WESLIE R JANEWAY...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(15) KENNETH KAUSHANSKY MD...................................................................... DIRECTOR (THROUGH 1/21)	1.00 .................	X		0	0	0
(16) RICHARD P LIFTON MD PHD...................................................................... DIRECTOR	1.00 .................	X		0	0	0
(17) EDISON T LIU MD...................................................................... DIRECTOR (THROUGH 2/21)	1.00 .................	X		0	0	0

Form 990 (2021)

Page 8

Part VII

Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)				(D) Reportable compensation from the organization (W-2/1099-MISC/1099-NEC)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)	(F) Estimated amount of other compensation from the organization and related organizations
(A) Name and title
(18) HERB PARDES MD........................................................................ DIRECTOR & VICE CHAIR	1.00 .......................	X				0	0	0
(19) ANIL RUSTGI MD........................................................................ DIRECTOR (AS OF 2/21)	1.00 .......................	X				0	0	0
(20) IVAN G SEIDENBERG MBA........................................................................ DIRECTOR & CO-CHAIR	4.00 .......................	X	X			0	0	0
(21) FRANK V SICA........................................................................ DIRECTOR & COMMITTEE CHAIR	1.00 .......................	X				0	0	0
(22) JIM SIMONS PHD........................................................................ DIRECTOR	1.00 .......................	X				0	0	0
(23) BRUCE STILLMAN PHD........................................................................ DIRECTOR	1.00 .......................	X				0	0	0
(24) CRAIG B THOMPSON MD........................................................................ DIRECTOR	1.00 .......................	X				0	0	0
(25) GORDON F TOMASELLI MD........................................................................ DIRECTOR	1.00 .......................	X				0	0	0
(26) KEVIN J TRACEY MD........................................................................ DIRECTOR	1.00 .......................	X				0	0	0
(27) ELIZABETH BROOKS O'BRIEN........................................................................ VP & GENERAL COUNSEL	40.00 .......................		X			440,292	0	40,576
(28) THOMAS LEHNER........................................................................ SCI DIR, NEURO DIS GEN	40.00 .......................			X		362,827	0	49,280
(29) SOREN GERMER........................................................................ SVP, GENOME TECHNOLOGIES	40.00 .......................			X		410,837	0	34,047
(30) CAROL ASHE........................................................................ CHIEF BUSINESS OFFICER	40.00 .......................			X		405,036	0	36,117
(31) CHARLES GAGNON........................................................................ SENIOR DIR, IT INFRASTRUCTURE	40.00 .......................			X		340,516	0	46,990
(32) MARIA JOANTA........................................................................ CHIEF FIN. OFFICER (AS OF 7/21)	40.00 .......................			X		169,606	0	19,229
(33) MICHAEL CHARLES ZODY........................................................................ SCIENTIFIC DIR, COMP BIOLOGY	40.00 .......................			X		277,755	0	23,134
(34) KAREN L BUNTING........................................................................ SENIOR DIRECTOR, STRATEGIC INITIATIVES	40.00 .......................				X	226,078	0	18,686
(35) SHAILAJA GARGEYA........................................................................ SENIOR DIR, SOFTWARE ENGINEER	40.00 .......................				X	318,002	0	17,787
(36) DAYNA M OSCHWALD........................................................................ CHIEF OF STAFF	40.00 .......................				X	258,478	0	31,335
(37) CHRISTOPHER PHIFER BLACK........................................................................ DIRECTOR, RESEARCH COMPUTING	40.00 .......................				X	218,966	0	42,403
(38) NICOLAS ROBINE........................................................................ COMPUTATIONAL BIOLOGY	40.00 .......................				X	213,550	0	37,197

1b	Sub-Total................
c	Total from continuation sheets to Part VII, Section A....
d	Total (add lines 1b and 1c)...........	4,886,961	0	415,048

Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet

Yes

Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............

For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual...........................

Yes

Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........

Section B. Independent Contractors

Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.

(A) Name and business address	(B) Description of services	(C) Compensation
DONNELLY MECHANICAL 96-59 222ND STREET QUEENS,NY11429	ENGINEERING SERVICES	720,835
GUARDIAN SERVICES INDUSTRIES INC 88005 EXPEDITE WAY CHICAGO,IL60695	CLEANING SERVICES	353,833
TEC SYSTEMS INC 47-25 34TH STREET 4TH FLOOR LONG ISLAND CITY,NY11101	MAINTENANCE SERVICES	177,232
HOWSON & HOWSON LLP 5 SENTRY PKWY 160 BLUE BELL,PA19422	LEGAL SERVICES	134,310
KPMG LLP PO BOX 120511 DALLAS,TX75312	ACCOUNTING SERVICES	130,113
2 Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization 6

Form 990 (2021)

Page 9

Part VIII

Statement of Revenue

Check if Schedule O contains a response or note to any line in this Part VIII.............

(A)
Total revenue

(B)
Related or
exempt
function
revenue

(D)
Revenue
excluded from
tax under sections
512 - 514

1a	Federated campaigns..		1a
b	Membership dues..		1b	2,735,000
c	Fundraising events..		1c
d	Related organizations		1d
e	Government grants (contributions)		1e	14,510,236

f	All other contributions, gifts, grants, and similar amounts not included above		1f	44,311,689

g	Noncash contributions included in lines 1a - 1f:$		1g	2,724,243

h Total. Add lines 1a-1f.......		61,556,925

		Business Code
2a	RESEARCH SEQUENCING	541700	7,531,190	5,536,740	1,994,450
b	CLINICAL SEQUENCING	541700	1,471,418	1,471,418
c
d
e
f	All other program service revenue.
g	Total. Add lines 2a–2f .....		9,002,608

3 Investment income (including dividends, interest, and othersimilar amounts) ......			27,107			27,107
4 Income from investment of tax-exempt bond proceeds
5 Royalties...........			1,251,014			1,251,014
		(ii) Personal	(i) Real
6a	Gross rents		3,674,053	6a
b	Less: rental expenses		3,471,087	6b
c	Rental income or (loss)		202,966	6c
d	Net rental income or (loss).......			202,966			202,966
		(ii) Other	(i) Securities
7a	Gross amount from sales of assets other than inventory			7a
b	Less: cost or other basis and sales expenses			7b
c	Gain or (loss)			7c
d	Net gain or (loss).........
8a	Gross income from fundraising events (not including $ of contributions reported on line 1c). See Part IV, line 18 ....
			8a
b	Less: direct expenses ...		8b
c	Net income or (loss) from fundraising events..
9a	Gross income from gaming activities. See Part IV, line 19 ...
			9a
b	Less: direct expenses ...		9b
c	Net income or (loss) from gaming activities..
10a	Gross sales of inventory, less returns and allowances ..
			10a
b	Less: cost of goods sold ..		10b
c	Net income or (loss) from sales of inventory..
Business Code			Miscellaneous Revenue
11a	OTHER MISC REVENUE		900099	258,491			258,491
b
c
d	All other revenue ....
e	Total. Add lines 11a–11d ......			258,491
12	Total revenue. See instructions.....			72,299,111	7,008,158	1,994,450	1,739,578

Form 990 (2021)

Page 10

Part IX

Statement of Functional Expenses

Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX..............

Do not include amounts reported on lines 6b, 7b, 8b, 9b, and 10b of Part VIII.		(A) Total expenses	(B) Program service expenses	(C) Management and general expenses	(D) Fundraising expenses

1	Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 ....	1,593,681	1,593,681
2	Grants and other assistance to domestic individuals. See Part IV, line 22 ...........
3	Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. .............	166,389	166,389
4	Benefits paid to or for members .......
5	Compensation of current officers, directors, trustees, and key employees ...........	5,255,579	2,109,697	3,002,312	143,570
6	Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........	185,902	185,902
7	Other salaries and wages........	16,703,387	13,108,257	3,495,018	100,112
8	Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) ....	1,123,438	801,984	306,866	14,588
9	Other employee benefits .......	2,096,930	1,394,563	687,694	14,673
10	Payroll taxes ...........	2,035,272	1,511,007	503,650	20,615
11	Fees for services (non-employees):
a	Management ......
b	Legal .........	235,238		235,238
c	Accounting ...........	127,060		127,060
d	Lobbying ...........	50,859		45,859	5,000
e	Professional fundraising services. See Part IV, line 17	250			250
f	Investment management fees ......
g	Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O)	2,558,552	2,306,294	252,258
12	Advertising and promotion ....
13	Office expenses .......	314,627	110,256	203,938	433
14	Information technology ......	3,110,631	2,836,025	274,606
15	Royalties ..	395,340	395,340
16	Occupancy ...........	14,120,934	11,710,583	2,303,138	107,213
17	Travel ............	67,457	66,669	775	13
18	Payments of travel or entertainment expenses for any federal, state, or local public officials .
19	Conferences, conventions, and meetings ....	37,508	28,590	8,486	432
20	Interest ...........	268,263	188,575	76,689	2,999
21	Payments to affiliates .......
22	Depreciation, depletion, and amortization ..	5,665,542	5,222,851	405,257	37,434
23	Insurance ...	660,185		660,185
24	Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a	DIRECT COST OF SEQUENCI	9,496,551	9,496,551
b	RESEARCH	2,524,924	2,524,924
c	RECRUITMENT	200,665	49,525	151,140
d	OTHER	113,257	25,858	81,182	6,217
e	All other expenses
25	Total functional expenses. Add lines 1 through 24e	69,108,421	55,833,521	12,821,351	453,549
26	Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here if following SOP 98-2 (ASC 958-720).

Form 990 (2021)

Page 11

Part X

Balance Sheet

Check if Schedule O contains a response or note to any line in this Part IX..............

				(A) Beginning of year		(B) End of year

1	Cash–non-interest-bearing ........			9,393,791	1	10,264,308
2	Savings and temporary cash investments .........				2
3	Pledges and grants receivable, net ......			4,575,195	3	7,859,130
4	Accounts receivable, net .............			4,431,588	4	6,350,857
5	Loans and other receivables from any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
					5
6	Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
					6
7	Notes and loans receivable, net ...........				7
8	Inventories for sale or use ............			1,246,622	8	2,423,898
9	Prepaid expenses and deferred charges ......			3,918,628	9	3,304,280
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	133,048,124
b	Less: accumulated depreciation	10b	85,581,035	51,267,221	10c	47,467,089
11	Investments—publicly traded securities .				11
12	Investments—other securities. See Part IV, line 11 .....				12
13	Investments—program-related. See Part IV, line 11 ..				13
14	Intangible assets ...............				14
15	Other assets. See Part IV, line 11 ...........			8,714,187	15	7,552,563
16	Total assets. Add lines 1 through 15 (must equal line 33)...			83,547,232	16	85,222,125

17	Accounts payable and accrued expenses .....	6,075,510	17	5,032,047
18	Grants payable ...		18
19	Deferred revenue .........	11,521,530	19	12,695,217
20	Tax-exempt bond liabilities .........		20
21	Escrow or custodial account liability. Complete Part IV of Schedule D		21
22	Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
			22
23	Secured mortgages and notes payable to unrelated third parties ..	71,442	23	0
24	Unsecured notes and loans payable to unrelated third parties ..	4,820,000	24	4,100,000
25	Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D	25,106,784	25	24,252,205
26	Total liabilities. Add lines 17 through 25..	47,595,266	26	46,079,469

	Organizations that follow FASB ASC 958, check here and complete lines 27, 28, 32, and 33.
27	Net assets without donor restrictions ..........	27,915,254	27	26,513,021
28	Net assets with donor restrictions ...........	8,036,712	28	12,629,635
	Organizations that do not follow FASB ASC 958, check here and complete lines 29 through 33.
29	Capital stock or trust principal, or current funds .....		29
30	Paid-in or capital surplus, or land, building or equipment fund ...		30
31	Retained earnings, endowment, accumulated income, or other funds		31
32	Total net assets or fund balances ...........	35,951,966	32	39,142,656
33	Total liabilities and net assets/fund balances ........	83,547,232	33	85,222,125

Form 990 (2021)

Page 12

Part XI

Reconcilliation of Net Assets

Check if Schedule O contains a response or note to any line in this Part XI..............

Total revenue (must equal Part VIII, column (A), line 12) ............

72,299,111

Total expenses (must equal Part IX, column (A), line 25) ............

69,108,421

Revenue less expenses. Subtract line 2 from line 1 ..............

3,190,690

Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ..

35,951,966

Net unrealized gains (losses) on investments ...............

Donated services and use of facilities .................

Investment expenses .....................

Prior period adjustments .....................

Other changes in net assets or fund balances (explain in Schedule O) ........

Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32, column (B))

39,142,656

Part XII

Financial Statements and Reporting

Check if Schedule O contains a response or note to any line in this Part XII.............

Yes

Accounting method used to prepare the Form 990: Cash Accrual Other
If the organization changed its method of accounting from a prior year or checked "Other," explain on
Schedule O.

Were the organization’s financial statements compiled or reviewed by an independent accountant?

If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:

Separate basis Consolidated basis Both consolidated and separate basis

Were the organization’s financial statements audited by an independent accountant?

Yes

If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:

Separate basis Consolidated basis Both consolidated and separate basis

If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?

Yes

If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.

As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?

Yes

If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.

Yes

Form 990 (2021)

Additional Data

Software ID:
Software Version:

Form 990, Special Condition Description:

Special Condition Description

- TIN:

SCHEDULE A
(Form 990)

Department of the Treasury
Internal Revenue Service

Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow

Attach to Form 990 or Form 990-EZ.
right arrow

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

Reason for Public Charity Status (All organizations must complete this part.) See instructions.

The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)

A church, convention of churches, or association of churches described in section 170(b)(1)(A)(i).

A school described in section 170(b)(1)(A)(ii). (Attach Schedule E (Form 990).)

A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name, city, and state:

An organization operated for the benefit of a college or university owned or operated by a governmental unit described in section 170(b)(1)(A)(iv). (Complete Part II.)

A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in section 170(b)(1)(A)(vi). (Complete Part II.)

A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)

An agricultural research organization described in 170(b)(1)(A)(ix) operated in conjunction with a land-grant college or university or a non-land grant college of agriculture. See instructions. Enter the name, city, and state of the college or university:

An organization that normally receives: (1) more than 33 1/3% of its support from contributions, membership fees, and gross receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 33 1/3% of its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)

An organization organized and operated exclusively to test for public safety. See section 509(a)(4).

An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box on lines 12a through 12d that describes the type of supporting organization and complete lines 12e, 12f, and 12g.

Type I. A supporting organization operated, supervised, or controlled by its supported organization(s), typically by giving the supported organization(s) the power to regularly appoint or elect a majority of the directors or trustees of the supporting organization. You must complete Part IV, Sections A and B.

Type II. A supporting organization supervised or controlled in connection with its supported organization(s), by having control or management of the supporting organization vested in the same persons that control or manage the supported organization(s). You must complete Part IV, Sections A and C.

Type III functionally integrated. A supporting organization operated in connection with, and functionally integrated with, its supported organization(s) (see instructions). You must complete Part IV, Sections A, D, and E.

Type III non-functionally integrated. A supporting organization operated in connection with its supported organization(s) that is not functionally integrated. The organization generally must satisfy a distribution requirement and an attentiveness requirement (see instructions). You must complete Part IV, Sections A and D, and Part V.

Check this box if the organization received a written determination from the IRS that it is a Type I, Type II, Type III functionally integrated, or Type III non-functionally integrated supporting organization.

Enter the number of supported organizations ...............................

Provide the following information about the supported organization(s).

(i) Name of supported organization	(ii) EIN	(iv) Is the organization listed in your governing document?		(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)
(i) Name of supported organization	(ii) EIN	Yes	No	(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)


Total

For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.

Cat. No. 11285F

Schedule A (Form 990) 2021

Page 2

Part II

Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") ..	70,723,214	115,038,771	32,878,926	51,639,109	61,556,925	331,836,945
2	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....
3	The value of services or facilities furnished by a governmental unit to the organization without charge..
4	Total. Add lines 1 through 3	70,723,214	115,038,771	32,878,926	51,639,109	61,556,925	331,836,945
5	The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) ..						159,305,553
6	Public support. Subtract line 5 from line 4.						172,531,392

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
7	Amounts from line 4..	70,723,214	115,038,771	32,878,926	51,639,109	61,556,925	331,836,945
8	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...	378,725	2,090,669	3,205,975	3,312,682	4,952,174	13,940,225
9	Net income from unrelated business activities, whether or not the business is regularly carried on..
10	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..	95,299	104,653	38,049	742,082	258,491	1,238,574
11	Total support. Add lines 7 through 10						347,015,744

Gross receipts from related activities, etc. (see instructions) ..................

63,775,539

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here ........................................ right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 6, column (f) divided by line 11, column (f)) .........

49.720 %

Public support percentage for 2020 Schedule A, Part II, line 14 ...............

54.290 %

16a

33 1/3% support test—2021. If the organization did not check the box on line 13, and line 14 is 33 1/3 % or more, check this box
and stop here. The organization qualifies as a publicly supported organization ....................... right arrow

33 1/3% support test—2020. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow

17a

10%-facts-and-circumstances test—2021. If the organization did not check a box on line 13, 16a, or 16b, and line 14
is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain
in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported
organization ..................................................... right arrow

10%-facts-and-circumstances test—2020. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line
15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here.
Explain in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly
supported organization ................................................ right arrow

Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow

Schedule A (Form 990) 2021

Page 3

Part III

Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .
2	Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose
3	Gross receipts from activities that are not an unrelated trade or business under section 513 .....
4	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5	The value of services or facilities furnished by a governmental unit to the organization without charge
6	Total. Add lines 1 through 5
7a	Amounts included on lines 1, 2, and 3 received from disqualified persons
b	Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.
c	Add lines 7a and 7b..
8	Public support. (Subtract line 7c from line 6.)

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
9	Amounts from line 6...
10a	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
b	Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.
c	Add lines 10a and 10b.
11	Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on.
12	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..
13	Total support. (Add lines 9, 10c, 11, and 12.)..

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,
check this box and stop here............................................. right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 8, column (f) divided by line 13, column (f)) .........

Public support percentage from 2020 Schedule A, Part III, line 15 ...............

Section D. Computation of Investment Income Percentage

Investment income percentage for 2021 (line 10c, column (f) divided by line 13, column (f)) ......

Investment income percentage from 2020 Schedule A, Part III, line 17 .............

19a

331/3% support tests—2021. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ....... right arrow

33 1/3% support tests—2020. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization .... right arrow

Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions .... right arrow

Schedule A (Form 990) 2021

Page 4

Part IV

Supporting Organizations

(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, of Part I, complete Sections A and B. If you checked box 12b, of Part I, complete Sections A and C. If you checked box 12c, of Part I, complete Sections A, D, and E. If you checked box12d, of Part I, complete Sections A and D, and complete Part V.)

Section A. All Supporting Organizations

Yes

Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.

Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).

Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer lines 3b and 3c below.

Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.

Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.

Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below.

Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.

Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.

Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).

Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?

Substitutions only. Was the substitution the result of an event beyond the organization's control?

Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.

Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990) .

Did the organization make a loan to a disqualified person (as defined in section 4958) not described on line 7? If “Yes,” complete Part I of Schedule L (Form 990).

Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons, as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.

Did one or more disqualified persons (as defined on line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.

Did a disqualified person (as defined on line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.

10a

Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.

10a

Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).

10b

Schedule A (Form 990) 2021

Page 5

Part IV

Supporting Organizations (continued)

Yes

Has the organization accepted a gift or contribution from any of the following persons?

A person who directly or indirectly controls, either alone or together with persons described on lines 11b and 11c below, the governing body of a supported organization?

11a

A family member of a person described on 11a above?

11b

A 35% controlled entity of a person described on line 11a or 11b above? If “Yes” to 11a, 11b, or 11c, provide detail in Part VI.

11c

Section B. Type I Supporting Organizations

Yes

Did the officers, directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.

Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.

Section C. Type II Supporting Organizations

Yes

Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).

Section D. All Type III Supporting Organizations

Yes

Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?

Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).

By reason of the relationship described in line 2 above, did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.

Section E. Type III Functionally-Integrated Supporting Organizations

Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):

The organization satisfied the Activities Test. Complete line 2 below.

The organization is the parent of each of its supported organizations. Complete line 3 below.

The organization supported a governmental entity. Describe in Part VI how you supported a government entity (see instructions)

Activities Test. Answer lines 2a and 2b below.

Yes

Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.

Did the activities described on line 2a, above constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.

Parent of Supported Organizations. Answer lines 3a and 3b below.

Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations?If "Yes" or "No", provide details in Part VI.

Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.

Schedule A (Form 990) 2021

Page 6

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations

Check here if the organization satisfied the Integral Part Test as a qualifying trust on Nov. 20, 1970 (explain in Part VI). See instructions. All other Type III non-functionally integrated supporting organizations must complete Sections A through E.

	Section A - Adjusted Net Income		(A) Prior Year	(B) Current Year (optional)
1	Net short-term capital gain	1
2	Recoveries of prior-year distributions	2
3	Other gross income (see instructions)	3
4	Add lines 1 through 3	4
5	Depreciation and depletion	5
6	Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions)	6
7	Other expenses (see instructions)	7
8	Adjusted Net Income (subtract lines 5, 6 and 7 from line 4)	8

	Section B - Minimum Asset Amount		(A) Prior Year	(B) Current Year (optional)
1	Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year):	1
a	Average monthly value of securities	1a
b	Average monthly cash balances	1b
c	Fair market value of other non-exempt-use assets	1c
d	Total (add lines 1a, 1b, and 1c)	1d
e	Discount claimed for blockage or other factors (explain in detail in Part VI):
2	Acquisition indebtedness applicable to non-exempt use assets	2
3	Subtract line 2 from line 1d	3
4	Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions).	4
5	Net value of non-exempt-use assets (subtract line 4 from line 3)	5
6	Multiply line 5 by 0.035	6
7	Recoveries of prior-year distributions	7
8	Minimum Asset Amount (add line 7 to line 6)	8

	Section C - Distributable Amount		Current Year
1	Adjusted net income for prior year (from Section A, line 8, Column A)	1
2	Enter 85% of line 1	2
3	Minimum asset amount for prior year (from Section B, line 8, Column A)	3
4	Enter greater of line 2 or line 3	4
5	Income tax imposed in prior year	5
6	Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions)	6

Check here if the current year is the organization's first as a non-functionally-integrated Type III supporting organization (see instructions)

Schedule A (Form 990) 2021

Page 7

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)

Section D - Distributions		Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes	1
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity	2
3 Administrative expenses paid to accomplish exempt purposes of supported organizations	3
4 Amounts paid to acquire exempt-use assets	4
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI)	5
6 Other distributions (describe in Part VI). See instructions	6
7Total annual distributions. Add lines 1 through 6.	7
8 Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions	8
9 Distributable amount for 2021 from Section C, line 6	9
10 Line 8 amount divided by Line 9 amount	10

Section E - Distribution Allocations (see instructions)		(i) Excess Distributions	(ii) Underdistributions Pre-2021	(iii) Distributable Amount for 2021
1 Distributable amount for 2021 from Section C, line 6
2 Underdistributions, if any, for years prior to 2021 (reasonable cause required-- explain in Part VI). See instructions.
3 Excess distributions carryover, if any, to 2021:
a From 2016.......
b From 2017.......
c From 2018.......
d From 2019.......
e From 2020.......
fTotal of lines 3a through e
g Applied to underdistributions of prior years
h Applied to 2021 distributable amount
i Carryover from 2016 not applied (see instructions)
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.
4Distributions for 2021 from Section D, line 7:
$
a Applied to underdistributions of prior years
b Applied to 2021 distributable amount
c Remainder. Subtract lines 4a and 4b from line 4.
5 Remaining underdistributions for years prior to 2021, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions.
6 Remaining underdistributions for 2021. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions.
7 Excess distributions carryover to 2022. Add lines 3j and 4c.
8 Breakdown of line 7:
a Excess from 2017.....
b Excess from 2018.....
c Excess from 2019.....
d Excess from 2020.....
e Excess from 2021.....

Schedule A (Form 990) (2021)

Schedule A (Form 990) 2021

Page 8

Part VI

Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Return Reference	Explanation

Schedule A (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule B
(Form 990)

Department of the Treasury
Internal Revenue Service

Schedule of Contributors

Attach to Form 990, 990-EZ, or 990-PF.

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Organization type (check one):

Filers of:

Section:

Form 990 or 990-EZ

501(c)( ) (enter number) organization

4947(a)(1) nonexempt charitable trust not treated as a private foundation

527 political organization

Form 990-PF

501(c)(3) exempt private foundation

4947(a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule.
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.

General Rule

For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, contributions totaling $5,000 or more (in money or other property) from any one contributor. Complete Parts I and II. See instructions for determining a contributor's total contributions.

Special Rules

For an organization described in section 501(c)(3) filing Form 990 or 990-EZ that met the 33¹/3% support test of the regulations
under sections 509(a)(1) and 170(b)(1)(A)(vi), that checked Schedule A (Form 990 or 990-EZ), Part II, line 13, 16a, or 16b, and that received from any one contributor, during the year, total contributions of the greater of (1) $5,000 or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h, or (ii) Form 990-EZ, line 1. Complete Parts I and II.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, total contributions of more than $1,000 exclusively for religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals. Complete Parts I, II, and III.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, contributions exclusively for religious, charitable, etc., purposes, but no such contributions totaled more than $1,000. If this box is checked, enter here the total contributions that were received during the year for an exclusively religious, charitable, etc., purpose. Don't complete any of the parts unless the General Rule applies to this organization because it received nonexclusively religious, charitable, etc., contributions totaling $5,000 or more during the year ......... Arrow Bullet

Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).

For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.

Cat. No. 30613XSchedule B (Form 990) (2021)

Schedule B (Form 990) (2021) Page 2

Name of organization NEW YORK GENOME CENTER INC

Part I Contributors	Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
RESTRICTED	,	$ RESTRICTED	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 3

Name of organization NEW YORK GENOME CENTER INC		Employer identification number 80-0631734

Part II	Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 4


Name of organization NEW YORK GENOME CENTER INC			Employer identification number 80-0631734
Part III Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) $ Use duplicate copies of Part III if additional space is needed.

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

Schedule B (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE C
(Form 990)

Department of the Treasury
Internal Revenue Service

Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527

SchCMd Bullet

Complete if the organization is described below. SchCMd Bullet

Attach to Form 990 or Form 990-EZ.
SchCMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet

Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet

Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet

Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet

Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet

Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet

Section 501(c)(4), (5), or (6) organizations: Complete Part III.

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I-A

Complete if the organization is exempt under section 501(c) or is a section 527 organization.

Provide a description of the organization’s direct and indirect political campaign activities in Part IV. See instructions for definition of “political campaign activities."

Political campaign activity expenditures. See instructions .................................................................... SchCMd Bullet

Volunteer hours for political campaign activities. See instructions ..................................................................

Part I-B

Complete if the organization is exempt under section 501(c)(3).

Enter the amount of any excise tax incurred by the organization under section 4955 ................................ SchCMd Bullet

Enter the amount of any excise tax incurred by organization managers under section 4955 ....................... SchCMd Bullet

If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................

Yes No

Was a correction made? ......................................................................................................................

Yes No

If "Yes," describe in Part IV.

Part I-C

Complete if the organization is exempt under section 501(c), except section 501(c)(3).

Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet

Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................ SchCMd Bullet

Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b........... SchCMd Bullet

Did the filing organization file Form 1120-POL for this year? ...................................................................

Yes No

Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.

(a) Name	(b) Address	(c) EIN	(d) Amount paid from filing organization's funds. If none, enter -0-.	(e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6

For Paperwork Reduction Act Notice, see the instructions for Form 990.

Cat. No. 50084S

Schedule C (Form 990) 2021

Page 2

Part II-A

Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).

A Check SchCMd Bullet

if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN, expenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet

if the filing organization checked box A and "limited control" provisions apply.

Limits on Lobbying Expenditures (The term "expenditures" means amounts paid or incurred.)		(b) Affiliated group totals
1a	Total lobbying expenditures to influence public opinion (grass roots lobbying) ......................
b	Total lobbying expenditures to influence a legislative body (direct lobbying) ........................
c	Total lobbying expenditures (add lines 1a and 1b) ............................................................
d	Other exempt purpose expenditures ...............................................................................
e	Total exempt purpose expenditures (add lines 1c and 1d) ..................................................
f	Lobbying nontaxable amount. Enter the amount from the following table in both columns.
	If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
	Not over $500,00020% of the amount on line 1e.
	Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
	Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
	Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
	Over $17,000,000$1,000,000.

g	Grassroots nontaxable amount (enter 25% of line 1f) .................................................
h	Subtract line 1g from line 1a. If zero or less, enter -0-. ................................................
i	Subtract line 1f from line 1c. If zero or less, enter -0-. ................................................
j	If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting section 4911 tax for this year? ...................................................................................................................	Yes No

4-Year Averaging Period Under Section 501(h) (Some organizations that made a section 501(h) election do not have to complete all of the five columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
	Calendar year (or fiscal year beginning in)	(a) 2018	(b) 2019	(c) 2020	(d) 2021	(e) Total

2a	Lobbying nontaxable amount

b	Lobbying ceiling amount (150% of line 2a, column(e))

c	Total lobbying expenditures

d	Grassroots nontaxable amount

e	Grassroots ceiling amount (150% of line 2d, column (e))

f	Grassroots lobbying expenditures

Schedule C (Form 990) 2021

Page 3

Part II-B

Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).

For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.

(a)

Yes|No

(b)

Amount

During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:

Volunteers? ...........................................................................................................

Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........

Yes

Media advertisements? ...................................................................................................

Mailings to members, legislators, or the public? .............................................................................

Publications, or published or broadcast statements? ...........................................................

Grants to other organizations for lobbying purposes? ..........................................................

Direct contact with legislators, their staffs, government officials, or a legislative body? .......................

Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................

Other activities? ...................................................................................................................

Yes

52,638

Total. Add lines 1c through 1i ....................................................................................................

52,638

Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....

If "Yes," enter the amount of any tax incurred under section 4912 ...........................................

If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................

If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................

Part III-A

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).

Yes

Were substantially all (90% or more) dues received nondeductible by members? ...............................................

Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................

Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................

Part III-B

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."

Dues, assessments and similar amounts from members ......................................................................

Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).

Current year .............................................................................................................................

Carryover from last year ............................................................................................................

Total ...........................................................................................................................................

Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .

If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................

Taxable amount of lobbying and political expenditures. See Instructions .........................................

Part IV

Supplemental Information

Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.

Return Reference	Explanation
PART II-B, LINE 1:	THROUGH ITS LEGISLATIVE CONSULTANTS, NYGC ADVOCATES AT THE STATE LEVEL FOR GOVERNMENT FUNDS TO SUPPORT CURRENT OPERATIONS AND/OR EXPAND RESEARCH OPPORTUNITIES AT NYGC. IN 2021, NYGC ENGAGED PAID LEGISLATIVE CONSULTANTS TO REPRESENT ITS INTERESTS AT THE STATE LEVEL. ADDITIONALLY, FROM TIME TO TIME, NYGC STAFF MAY CONTACT MEMBERS OF THE STATE LEGISLATURE AND EXECUTIVE BRANCH TO ENCOURAGE THEIR SUPPORT FOR NYGC. SUCH CONTACT MAY INCLUDE MEETINGS AND CORRESPONDENCE WITH PUBLIC OFFICIALS. THE APPROXIMATE COST ASSOCIATED WITH THESE ACTIVITIES IN 2021 WAS $23,377. NYGC ALSO MAINTAINS MEMBERSHIPS IN IRC SECTION 501(C)(6) ORGANIZATIONS THAT REPRESENT THE INTERESTS OF THE ACADEMIC MEDICAL RESEARCH COMMUNITY. IN 2021, $2,388 OF THE DUES THAT NYGC PAID TO THESE ASSOCIATIONS WERE ATTRIBUTABLE TO LOBBYING.

Return Reference

Explanation

PART II-B, LINE 1:

THROUGH ITS LEGISLATIVE CONSULTANTS, NYGC ADVOCATES AT THE STATE LEVEL FOR GOVERNMENT FUNDS TO SUPPORT CURRENT OPERATIONS AND/OR EXPAND RESEARCH OPPORTUNITIES AT NYGC. IN 2021, NYGC ENGAGED PAID LEGISLATIVE CONSULTANTS TO REPRESENT ITS INTERESTS AT THE STATE LEVEL. ADDITIONALLY, FROM TIME TO TIME, NYGC STAFF MAY CONTACT MEMBERS OF THE STATE LEGISLATURE AND EXECUTIVE BRANCH TO ENCOURAGE THEIR SUPPORT FOR NYGC. SUCH CONTACT MAY INCLUDE MEETINGS AND CORRESPONDENCE WITH PUBLIC OFFICIALS. THE APPROXIMATE COST ASSOCIATED WITH THESE ACTIVITIES IN 2021 WAS $23,377. NYGC ALSO MAINTAINS MEMBERSHIPS IN IRC SECTION 501(C)(6) ORGANIZATIONS THAT REPRESENT THE INTERESTS OF THE ACADEMIC MEDICAL RESEARCH COMMUNITY. IN 2021, $2,388 OF THE DUES THAT NYGC PAID TO THESE ASSOCIATIONS WERE ATTRIBUTABLE TO LOBBYING.

Schedule C (Form 990) 2021

Additional Data

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SCHEDULE D
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Financial Statements

Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet

Attach to Form 990.
SchDMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.

		(a) Donor advised funds	(b) Funds and other accounts
1	Total number at end of year .........
2	Aggregate value of contributions to (during year)
3	Aggregate value of grants from (during year)
4	Aggregate value at end of year ........

Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............

Yes No

Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................

Yes No

Part II

Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.

Purpose(s) of conservation easements held by the organization (check all that apply).

Preservation of land for public use (e.g., recreation or education) Preservation of an historically important land area

Protection of natural habitat Preservation of a certified historic structure

Preservation of open space

Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.


a	Total number of conservation easements ......................	2a
b	Total acreage restricted by conservation easements ....................	2b
c	Number of conservation easements on a certified historic structure included in (a) .....	2c
d	Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ...	2d

Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet

Number of states where property subject to conservation easement is located SchDMd Bullet

Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............

Yes No

Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................

Yes No

In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.

If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.

If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:

(i)

Revenue included on Form 990, Part VIII, line 1 ......................... SchDMd Bullet

(ii)

Assets included in Form 990, Part X ............................... SchDMd Bullet

If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:

Revenue included on Form 990, Part VIII, line 1 .......................... SchDMd Bullet

Assets included in Form 990, Part X ............................... SchDMd Bullet

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 52283D

Schedule D (Form 990) 2021

Page 2

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)

Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):

Public exhibition

Loan or exchange programs

Scholarly research

Other

Preservation for future generations

Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.

During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...

Yes No

Part IV

Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.

Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................

Yes No


b	If "Yes," explain the arrangement in Part XIII and complete the following table:		Amount
c	Beginning balance .............................	1c
d	Additions during the year ............................	1d
e	Distributions during the year ..........................	1e
f	Ending balance ................................	1f

Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...

Yes No

If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....

Part V

Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.

		(a) Current year	(b) Prior year	(c) Two years back	(d) Three years back	(e) Four years back

1a	Beginning of year balance ....
b	Contributions ...
c	Net investment earnings, gains, and losses
d	Grants or scholarships ...
e	Other expenditures for facilities and programs ...
f	Administrative expenses ....
g	End of year balance ......

Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:

Board designated or quasi-endowment SchDMd Bullet

Permanent endowment SchDMd Bullet

Term endowment SchDMd Bullet

The percentages on lines 2a, 2b, and 2c should equal 100%.

Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes

(i) Unrelated organizations .................

3a(i)

(ii) Related organizations .................

3a(ii)

If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........

Describe in Part XIII the intended uses of the organization's endowment funds.

Part VI

Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.

Description of property		(a) Cost or other basis (investment)	(b) Cost or other basis (other)	(c) Accumulated depreciation	(d) Book value

1a	Land .....
b	Buildings ....
c	Leasehold improvements	71,059,157	26,565,746	44,493,411
d	Equipment ....	60,492,873	57,519,195	2,973,678
e	Other .....	1,496,094	1,496,094	0
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..				47,467,089

Schedule D (Form 990) 2021

Page 3

Part VII

Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.

(a) Description of security or category (including name of security)	(b) Book value	(c) Method of valuation: Cost or end-of-year market value
(1) Financial derivatives.........
(2) Closely-held equity interests........
(3)Other
(A)
(B)
(C)
(D)
(E)
(F)
(G)
(H)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)

Part VIII

Investments - Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.

(a) Description of investment	(b) Book value	(c) Method of valuation: Cost or end-of-year market value

(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)

Part IX

Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.

(a) Description				(b) Book value
(1)SECURITY DEPOSITS				7,339,122
(2)DEFERRED COMPENSATION				213,441
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........				7,552,563

Part X

Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.

1.(a) Description of liability	(b) Book value
(1) Federal income taxes
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)	24,252,205
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII

Schedule D (Form 990) 2021

Page 4

Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total revenue, gains, and other support per audited financial statements .......			1	75,770,198
2	Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a	Net unrealized gains (losses) on investments ....	2a
b	Donated services and use of facilities .........	2b
c	Recoveries of prior year grants ...........	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d .....................			2e	0
3	Subtract line 2e from line 1..................			3	75,770,198
4	Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b .	4a
b	Other (Describe in Part XIII.) ...........	4b	-3,471,087
c	Add lines 4a and 4b....................			4c	-3,471,087
5	Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ......			5	72,299,111

Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total expenses and losses per audited financial statements ...........			1	72,579,508
2	Amounts included on line 1 but not on Form 990, Part IX, line 25:
a	Donated services and use of facilities .........	2a
b	Prior year adjustments ............	2b
c	Other losses ................	2c
d	Other (Describe in Part XIII.) ............	2d	3,471,087
e	Add lines 2a through 2d....................			2e	3,471,087
3	Subtract line 2e from line 1...................			3	69,108,421
4	Amounts included on Form 990, Part IX, line 25, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b ..	4a
b	Other (Describe in Part XIII.) ............	4b
c	Add lines 4a and 4b.....................			4c	0
5	Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ......			5	69,108,421

Part XIII

Supplemental Information

Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.

Return Reference	Explanation
PART X, LINE 2:	NYGC IS SUBJECT TO THE PROVISIONS OF THE FASB ASC SECTION 740-10-05, INCOME TAXES - OVERALL, RELATING TO ACCOUNTING AND REPORTING FOR UNCERTAINTY IN INCOME TAXES. NYGC RECOGNIZES THE EFFECT OF INCOME TAX POSITIONS ONLY IF THOSE POSITIONS ARE MORE LIKELY THAN NOT OF BEING SUSTAINED AND HAS DETERMINED IT DID NOT HAVE ANY EXPOSURE TO UNCERTAIN TAX POSITIONS DURING 2021 AND 2020.
PART XI, LINE 4B - OTHER ADJUSTMENTS:	RENTAL EXPENSE -3,471,087.
PART XII, LINE 2D - OTHER ADJUSTMENTS:	RENTAL EXPENSE 3,471,087.

Schedule D (Form 990) 2021

Additional Data

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SCHEDULE F(Form 990)

Department of the Treasury
Internal Revenue Service

Statement of Activities Outside the United States

Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16. Right pointing arrow large image

Attach to Form 990. Right pointing arrow large image

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization
NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.

For grantmakers. Does the organization maintain records to substantiate the amount of its grants and

other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used

to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.

Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)

(a) Region		(b) Number of offices in the region	(c) Number of employees, agents, and independent contractors in the region	(d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region)	(e) If activity listed in (d) is a program service, describe specific type of service(s) in the region	(f) Total expenditures for and investments in the region
	EUROPE (INCLUDING ICELAND AND GREENLAND)		14	PROGRAM SERVICES	RESEARCH	480,577
	NORTH AMERICA		6	PROGRAM SERVICES	RESEARCH	172,931
	MIDDLE EAST (NORTH AFRICA)		1	PROGRAM SERVICES	RESEARCH	1,808
	EAST ASIA AND THE PACIFIC		1	PROGRAM SERVICES	RESEARCH	499
	EUROPE (INCLUDING ICELAND AND GREENLAND)		2	PROGRAM SERVICES	RESEARCH SUBAWARD	166,389












3a	Sub-total ....	0	24			822,204
b	Total from continuation sheets to Part I ...	0	0			0
c	Totals (add lines 3a and 3b)	0	24			822,204

For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2021

Schedule F (Form 990) 2021

Page 2

Part II

Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.

(c) Region	(d) Purpose of grant	(e) Amount of cash grant	(f) Manner of cash disbursement	(g) Amount of noncash assistance
EUROPE (INCLUDING ICELAND AND GREENLAND)	RESEARCH SUBAWARD	148,514	WIRE	0
EUROPE (INCLUDING ICELAND AND GREENLAND)	RESEARCH SUBAWARD	17,875	WIRE	0

2	Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......	2
3	Enter total number of other organizations or entities .......................	0

Schedule F (Form 990) 2021

Schedule F (Form 990) 2021Page 3

Part III

Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.

Part III can be duplicated if additional space is needed.

	(b) Region	(c) Number of recipients	(d) Amount of cash grant	(e) Manner of cash disbursement
RESEARCH	NORTH AMERICA	1	38,779	WIRE

Schedule F (Form 990) 2021

Page 4

Part IV

Foreign Forms

Schedule F (Form 990) 2021

Page 5

Part V

Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.

ReturnReference	Explanation
PART I, LINE 2:	NYGC MONITORS THE USE OF GRANT FUNDS FOLLOWING THE UNIFORM GUIDANCE FOR FEDERAL AWARDS. GRANT RECIPIENTS ARE REQUIRED TO PROVIDE PROGRESS REPORTS. COSTS ARE REVIEWED FOR ALLOWABILITY WITH REGARD TO RELEVANT COST PRINCIPLES, BUDGETARY RESTRICTIONS, AND TERMS AND CONDITIONS OF THE AWARD BEFORE PAYMENT.
PART I, LINE 3:	THE PROGRAM EXPENDITURES ARE REPORTED ON THE ACCRUAL METHOD.
PART III ACCOUNTING METHOD:

Schedule F (Form 990) 2021

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Schedule I
(Form 990)

Department of the Treasury
Internal Revenue Service

Grants and Other Assistance to Organizations,
Governments and Individuals in the United States

Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet

Attach to Form 990.
lBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
NEW YORK GENOME CENTER INC

Employer identification number
80-0631734

Part I

General Information on Grants and Assistance

Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................

Yes No

Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.

Part II

Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient

that received more than $5,000. Part II can be duplicated if additional space is needed.

(a) Name and address of organization or government	(b) EIN	(c) IRC section (if applicable)	(d) Amount of cash grant	(h) Purpose of grant or assistance
(1) NEW YORK UNIVERSITY 105 E 17TH STREET NEW YORK,NY10003	13-5562308	501(C)(3)	440,678	RESEARCH SUBAWARD
(2) COLD SPRING HARBOR LABORATORY ONE BUNGTOWN ROAD COLD SPRING HARBOR,NY11724	11-2013303	501(C)(3)	322,523	RESEARCH SUBAWARD
(3) COLUMBIA UNIVERSITY 615 WEST 131ST STREET NEW YORK,NY10027	13-5598093	501(C)(3)	227,755	RESEARCH SUBAWARD
(4) MEMORIAL SLOAN KETTERING CANCER CENTER 1275 YORK AVENUE NEW YORK,NY10065	13-1924236	501(C)(3)	110,207	RESEARCH SUBAWARD
(5) THE BROAD INSTITUTE INC 415 MAIN STREET CAMBRIDGE,MA02142	26-3428781	501(C)(3)	71,543	RESEARCH SUBAWARD
(6) ROCKEFELLER UNIVERSITY 1230 YORK AVENUE NEW YORK,NY10065	13-1624158	501(C)(3)	51,589	RESEARCH SUBAWARD
(7) UNIVERSITY OF WASHINGTON 129 SCHMITZ HALL 355870 SEATTLE,WA98195	91-6001537	WA	51,281	RESEARCH SUBAWARD
(8) WEILL CORNELL MEDICAL COLLEGE 1300 YORK AVENUE NEW YORK,NY10065	15-0532082	501(C)(3)	27,994	RESEARCH SUBAWARD
(9) YALE UNIVERSITY PO BOX 208356 NEW HAVEN,CT06520	06-0646973	501(C)(3)	15,918	RESEARCH SUBAWARD
(10) WASHINGTON UNIVERSITY SCHOOL OF MEDICINE 700 ROSEDALE AVENUE CB 1034 ST LOUIS,MO63112	43-0653611	501(C)(3)	9,113	RESEARCH SUBAWARD
(11) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ONE GUSTAVE L LEVY PLACE NEW YORK,NY10029	13-6171197	501(C)(3)	7,615	RESEARCH SUBAWARD
(12) JOHNS HOPKINS UNIVERSITY 3910 KESWICK ROAD BALTIMORE,MD21211	52-0595110	501(C)(3)	7,063	RESEARCH SUBAWARD

Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image

Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50055P

Schedule I (Form 990) 2021

Page 2

Part III

Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance	(b) Number of recipients	(c) Amount of cash grant	(d) Amount of noncash assistance	(e) Method of valuation (book, FMV, appraisal, other)	(f) Description of noncash assistance

(1)
(2)
(3)
(4)
(5)
(6)
(7)

Part IV

Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.

Return Reference	Explanation
PART I, LINE 2:	NYGC MONITORS THE USE OF GRANT FUNDS FOLLOWING THE UNIFORM GUIDANCE FOR FEDERAL AWARDS. GRANT RECIPIENTS ARE REQUIRED TO PROVIDE PROGRESS REPORTS. COSTS ARE REVIEWED FOR ALLOWABILITY WITH REGARD TO RELEVANT COST PRINCIPLES, BUDGETARY RESTRICTIONS, AND TERMS AND CONDITIONS OF THE AWARD BEFORE PAYMENT.

Schedule I (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule J
(Form 990)

Department of the Treasury
Internal Revenue Service

Compensation Information

For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet

Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet

Attach to Form 990.
SchJMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

Questions Regarding Compensation

Yes

Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.

First-class or charter travel Housing allowance or residence for personal use

Travel for companions Payments for business use of personal residence

Tax idemnification and gross-up payments Health or social club dues or initiation fees

Discretionary spending account Personal services (e.g., maid, chauffeur, chef)

If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .....

Yes

Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ....

Yes

Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.

Compensation committee Written employment contract

Independent compensation consultant Compensation survey or study

Form 990 of other organizations Approval by the board or compensation committee

During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:

Receive a severance payment or change-of-control payment? .............

Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........

Participate in, or receive payment from, an equity-based compensation arrangement? .........

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.

Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:

The organization? ....................

Any related organization? .......................

If "Yes," on line 5a or 5b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:

The organization? ..................

Any related organization? ......................

If "Yes," on line 6a or 6b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............

Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................

If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50053T

Schedule J (Form 990) 2021

Page 2

Part II

Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.

For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.

(A) Name and Title		(B) Breakdown of W-2, 1099-MISC compensation, and/or 1099-NEC			(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation in column (B) reported as deferred on prior Form 990
(A) Name and Title		(i) Base compensation	(ii) Bonus & incentive compensation	(iii) Other reportable compensation	(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)
1CHERYL A MOORE PRESIDENT & COO (THROUGH 3/21)	(i) (ii)	256,926 ------------- 0	244,600 ------------- 0	127,081 ------------- 0	17,400 ------------- 0	867 ------------- 0	646,874 ------------- 0	0 ------------- 0
2TOM MANIATIS PHD SCIENTIFIC DIRECTOR & CEO	(i) (ii)	612,312 ------------- 0	0 ------------- 0	4,099 ------------- 0	0 ------------- 0	0 ------------- 0	616,411 ------------- 0	0 ------------- 0
3ELIZABETH BROOKS O'BRIEN VP & GENERAL COUNSEL	(i) (ii)	440,292 ------------- 0	0 ------------- 0	0 ------------- 0	17,400 ------------- 0	23,176 ------------- 0	480,868 ------------- 0	0 ------------- 0
4SOREN GERMER SVP, GENOME TECHNOLOGIES	(i) (ii)	410,837 ------------- 0	0 ------------- 0	0 ------------- 0	17,400 ------------- 0	16,647 ------------- 0	444,884 ------------- 0	0 ------------- 0
5CAROL ASHE CHIEF BUSINESS OFFICER	(i) (ii)	405,036 ------------- 0	0 ------------- 0	0 ------------- 0	36,000 ------------- 0	117 ------------- 0	441,153 ------------- 0	18,600 ------------- 0
6THOMAS LEHNER SCI DIR, NEURO DIS GEN	(i) (ii)	362,827 ------------- 0	0 ------------- 0	0 ------------- 0	36,900 ------------- 0	12,380 ------------- 0	412,107 ------------- 0	18,101 ------------- 0
7CHARLES GAGNON SENIOR DIR, IT INFRASTRUCTURE	(i) (ii)	307,096 ------------- 0	29,160 ------------- 0	4,260 ------------- 0	17,286 ------------- 0	29,704 ------------- 0	387,506 ------------- 0	0 ------------- 0
8SHAILAJA GARGEYA SENIOR DIR, SOFTWARE ENGINEER	(i) (ii)	310,998 ------------- 0	7,004 ------------- 0	0 ------------- 0	17,400 ------------- 0	387 ------------- 0	335,789 ------------- 0	0 ------------- 0
9MICHAEL CHARLES ZODY SCIENTIFIC DIR, COMP BIOLOGY	(i) (ii)	277,755 ------------- 0	0 ------------- 0	0 ------------- 0	14,344 ------------- 0	8,790 ------------- 0	300,889 ------------- 0	0 ------------- 0
10DAYNA M OSCHWALD CHIEF OF STAFF	(i) (ii)	258,478 ------------- 0	0 ------------- 0	0 ------------- 0	14,688 ------------- 0	16,647 ------------- 0	289,813 ------------- 0	0 ------------- 0
11CHRISTOPHER PHIFER BLACK DIRECTOR, RESEARCH COMPUTING	(i) (ii)	218,966 ------------- 0	0 ------------- 0	0 ------------- 0	13,648 ------------- 0	28,755 ------------- 0	261,369 ------------- 0	0 ------------- 0
12NICOLAS ROBINE COMPUTATIONAL BIOLOGY	(i) (ii)	213,550 ------------- 0	0 ------------- 0	0 ------------- 0	13,154 ------------- 0	24,043 ------------- 0	250,747 ------------- 0	0 ------------- 0
13KAREN L BUNTING SENIOR DIRECTOR, STRATEGIC INITIATIV	(i) (ii)	226,078 ------------- 0	0 ------------- 0	0 ------------- 0	11,394 ------------- 0	7,292 ------------- 0	244,764 ------------- 0	0 ------------- 0
14MARIA JOANTA CHIEF FIN. OFFICER (AS OF 7/21)	(i) (ii)	169,606 ------------- 0	0 ------------- 0	0 ------------- 0	5,550 ------------- 0	13,679 ------------- 0	188,835 ------------- 0	0 ------------- 0

Schedule J (Form 990) 2021

Page 3

Part III

Supplemental Information

Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.

Return Reference

Explanation

PART I, LINE 1A

HOUSING ALLOWANCE OR RESIDENCE FOR PERSONAL USE NYGC SELECTIVELY OFFERS HOUSING ALLOWANCES TO EMPLOYEES, PRINCIPALLY AS A RECRUITING TOOL FOR NEW FACULTY AND POSTDOCTORAL FELLOWS. SUBSIDIZED HOUSING OR HOUSING ALLOWANCES ARE COMMONLY OFFERED BY PEER ACADEMIC INSTITUTIONS IN NEW YORK CITY TO HELP FACULTY AND OTHER RESEARCHERS DEFRAY THE HIGH COST OF HOUSING. THE VALUE OF THIS ASSISTANCE WAS TREATED AS TAXABLE COMPENSATION TO THE EMPLOYEE.

PART I, LINE 3

IN 2021, NYGC'S SCIENTIFIC DIRECTOR & CEO WAS EMPLOYED BY AN UNRELATED ENTITY AND LEASED TO NYGC TO DEVOTE 80% OF HIS TIME AND EFFORT TO SERVING AS NYGC'S SCIENTIFIC DIRECTOR & CEO, AN OFFICER OF THE CORPORATION AND AS A SENIOR ASSOCIATE MEMBER OF NYGC'S FACULTY. HE OVERSAW NYGC'S RESEARCH PROGRAM AND UNDERTOOK OTHER ACTIVITIES AS NYGC'S BOARD OF DIRECTORS REQUESTED FROM TIME TO TIME. THE SCIENTIFIC DIRECTOR & CEO DEVOTED 20% OF HIS TIME TO HIS DUTIES AT THE UNRELATED ENTITY, WHERE HE MAINTAINS A LABORATORY AND CONDUCTS INDEPENDENT, INVESTIGATOR-INITIATED RESEARCH PROJECTS. IN JANUARY 2021, NYGC HIRED AN INDEPENDENT COMPENSATION CONSULTANT TO PERFORM AN EXECUTIVE TOTAL COMPENSATION STUDY OF SENIOR MANAGEMENT'S COMPENSATION, INCLUDING THE SCIENTIFIC DIRECTOR & CEO. THE REVIEW SHOWED THAT THE COMPENSATION PAID TO ALL MEMBERS OF SENIOR MANAGEMENT, INCLUDING THE SCIENTIFIC DIRECTOR & CEO, WAS REASONABLE.

Schedule J (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule L
(Form 990)

Department of the Treasury
Internal Revenue Service

Transactions with Interested Persons

Complete if the organization answered "Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c, or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet

Attach to Form 990 or Form 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

Excess Benefit Transactions (section 501(c)(3), section 501(c)(4), and section 501(c)(29) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.

1(a) Name of disqualified person	(c) Description of transaction	(d) Corrected?
1(a) Name of disqualified person	(c) Description of transaction	Yes	No

Enter the amount of tax incurred by the organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image

Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ........ Bullet Image

Part II

Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22

(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	(d) Loan to or from the organization?		(e) Original principal amount	(f) Balance due	(g) In default?		(h) Approved by board or committee?		(i) Written agreement?
(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	To	From	(e) Original principal amount	(f) Balance due	Yes	No	Yes	No	Yes	No






Total ............... $

Part III

Grants or Assistance Benefiting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of assistance	(d) Type of assistance	(e) Purpose of assistance

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50056A

Schedule L (Form 990) 2021

Page 2

Part IV

Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of transaction	(d) Description of transaction	(e) Sharing of organization's revenues?
(a) Name of interested person		(c) Amount of transaction	(d) Description of transaction	Yes	No
(1) SILAS MANIATIS	FAMILY MEMBER	188,095	SALARY+BENEFITS		No

Part V

Supplemental Information
Provide additional information for responses to questions on Schedule L (see instructions).

Return Reference	Explanation

Schedule L (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE M
(Form 990)

Department of the Treasury

Internal Revenue Service

Noncash Contributions

Complete if the organizations answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image

Attach to Form 990.
Right pointing arrow large image

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Part I

Types of Property

	(a) Check if applicable	(b) Number of contributions or items contributed	(c) Noncash contribution amounts reported on Form 990, Part VIII, line 1g	(d) Method of determining noncash contribution amounts
1 Art—Works of art ....
2 Art—Historical treasures .
3 Art—Fractional interests ..
4 Books and publications ..
5 Clothing and household goods .......
6 Cars and other vehicles ..
7 Boats and planes ....
8 Intellectual property ...
9 Securities—Publicly traded .
10 Securities—Closely held stock .
11 Securities—Partnership, LLC, or trust interests ....
12 Securities—Miscellaneous ..
13 Qualified conservation contribution—Historic structures .....
14 Qualified conservation contribution—Other ...
15 Real estate—Residential .
16 Real estate—Commercial ..
17 Real estate—Other ...
18 Collectibles .....
19 Food inventory ...
20 Drugs and medical supplies .
21 Taxidermy ......
22 Historical artifacts ....
23 Scientific specimens ..
24 Archeological artifacts ...
25 Other ( RESEARCH SUPPLIES )	X	842	2,724,243	FMV
26 Other ( )
27 Other ( )
28 Other ( )

Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement

Yes

30a

During the year, did the organization receive by contribution any property reported in Part I, lines 1 through 28, that it must hold for at least three years from the date of the initial contribution, and which isn't required to be used for exempt purposes for the entire holding period? ...................

30a

If "Yes," describe the arrangement in Part II.

Does the organization have a gift acceptance policy that requires the review of any nonstandard contributions?

32a

Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash

contributions? ..........................

32a

If "Yes," describe in Part II.

If the organization didn't report an amount in column (c) for a type of property for which column (a) is checked,

describe in Part II.

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 51227J

Schedule M (Form 990) (2021)

Page 2

Part IISupplemental Information. Provide the information required by Part I, lines 30b, 32b, and 33, and whether the organization is reporting in Part I, column (b), the number of contributions, the number of items received, or a combination of both. Also complete this part for any additional information.

Return Reference	Explanation
PART I, COLUMN (B):	THE NUMBER REPORTED IN PART I, COLUMN B REPRESENTS THE NUMBER OF UNITS CONTRIBUTED.

Schedule M (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE O
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet

Attach to Form 990 or 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

NEW YORK GENOME CENTER INC

Employer identification number

80-0631734

Return Reference	Explanation
FORM 990, PART I, LINE 1 & PART III, LINE 1:	THE NEW YORK GENOME CENTER (NYGC) IS AN INDEPENDENT, NONPROFIT MEDICAL RESEARCH ORGANIZATION THAT SERVES AS A MULTI-INSTITUTIONAL HUB FOR GENOMIC RESEARCH. LEVERAGING OUR STRENGTHS IN WHOLE-GENOME SEQUENCING AND GENOMIC ANALYSIS, OUR MISSION IS THE ADVANCEMENT OF GENOMIC SCIENCE AND ITS APPLICATION TO NOVEL BIOMEDICAL DISCOVERIES. NYGC'S AREAS OF FOCUS INCLUDE THE DEVELOPMENT OF NOVEL COMPUTATIONAL AND EXPERIMENTAL METHODS IN GENOMICS AND DISEASE-FOCUSED RESEARCH. THE CENTER IS KNOWN INTERNATIONALLY FOR ENHANCING OUR UNDERSTANDING OF THE GENETIC BASIS OF CANCER, NEURODEGENERATIVE DISEASE (ALS, ALZHEIMER'S, FTD, PARKINSON'S AND HUNTINGTON'S), AND NEUROPSYCHIATRIC DISEASE (AUTISM, SCHIZOPHRENIA, BIPOLAR DISORDER). SINCE 2020, THE NYGC HAS ALSO DIRECTED ITS EXPERTISE TO COVID-19 RESEARCH. NYGC SERVES AS A NEXUS FOR COLLABORATION IN GENOMIC RESEARCH FOR THE NEW YORK COMMUNITY AND BEYOND, BUILDING ON THE COMBINED STRENGTHS OF FACULTY, MEMBER INSTITUTIONS, SCIENTIFIC WORKING GROUPS, AFFILIATE MEMBERS, AND INDUSTRY PARTNERS. NYGC'S GROWTH AND DEDICATION TO EXCELLENCE EMPOWERS THE CLINICAL AND SCIENTIFIC COMMUNITY WITH THE RESOURCES AND EXPERTISE TO ACCELERATE GENOMIC SCIENCE. THE NYGC TEAM, LED BY EVNIN FAMILY SCIENTIFIC DIRECTOR AND CEO TOM MANIATIS, PHD, INCLUDES SENIOR AND CORE FACULTY MEMBERS WHO HOLD JOINT APPOINTMENTS AT LEADING ACADEMIC INSTITUTIONS. THE FACULTY INCLUDES A NOBEL LAUREATE, SIX NATIONAL ACADEMY OF SCIENCES MEMBERS, THREE LASKER AWARD WINNERS, THREE NIH NEW INNOVATOR AWARD WINNERS, THREE NIH PATHWAY TO INDEPENDENCE AWARD WINNERS, AS WELL AS ONE NIH DIRECTOR'S TRANSFORMATIVE RESEARCH AWARDEE. NYGC HAS 16 MEMBER INSTITUTIONS AND 85 AFFILIATED SCIENTISTS IN ADDITION TO ITS INTERNAL SCIENTIFIC TEAM, ROBUST RESEARCH PROGRAMS, STATE-OF-THE-ART, NEXT GENERATION SEQUENCING/ANALYTICS CAPABILITIES, A CLINICAL LABORATORY CERTIFIED BY THE NEW YORK STATE DEPARTMENT OF HEALTH, AND A CUTTING-EDGE TECHNOLOGY INNOVATION TEAM. WE CONSIDER THE EXCHANGE OF IDEAS AMONG RESEARCHERS, BOTH WITHIN AND OUTSIDE THE CENTER, TO BE ESSENTIAL FOR THE UNDERSTANDING OF THE GENETIC BASIS OF HUMAN DISEASES, DEVELOPMENT OF NEW GENOMIC TECHNOLOGIES, AND THE ADVANCEMENT OF BASIC SCIENCE. NYGC STRIVES TO CHAMPION DIVERSITY, EQUITY, AND INCLUSION. IN ADDITION TO THE WORKPLACE THIS INCLUDES RESEARCH AND IN ITS APPLICATION TO CLINICAL CARE. A FUNDAMENTAL GOAL OF THE GENOME CENTER IS ADDRESSING THE LACK OF DIVERSITY WITHIN DATA SAMPLES AND SUBJECTS IN GENOMICS RESEARCH. NYGC IS ALSO COMMITTED TO EXPANDING DIVERSITY AS REFLECTED WITHIN THE CENTER'S BOARD OF DIRECTORS AND WITHIN THE FACULTY, STAFF, AND SCIENTIFIC RESEARCHERS.
FORM 990, PART III, LINE 4A & LINE 4B	NYGC IS COMMITTED TO ITS MISSION OF ADVANCING GENOMIC SCIENCE AND ITS APPLICATION TO NOVEL BIOMEDICAL THERAPEUTICS AND ACCELERATE ITS USE IN THE CLINICAL SETTING. RESEARCH AND FACULTY --------------------- NYGC ATTRACTS WORLD-CLASS SCIENTISTS AND IS COMMITTED TO SUPPORTING EMERGING YOUNG FACULTY. NYGC RESEARCHERS HAVE BACKGROUNDS IN SINGLE CELL GENOMICS, GENOMIC ENGINEERING, EVOLUTIONARY GENOMICS, TECHNOLOGY AND METHODS DEVELOPMENT, COMPUTATIONAL BIOLOGY AND BIOENGINEERING. MOST FACULTY MEMBERS HAVE JOINT APPOINTMENTS AT ONE OF NYGC'S PARTNER INSTITUTIONS TO PROMOTE PRODUCTIVE COLLABORATION, STRENGTHEN RESEARCH, ADVANCE ACADEMIC LEADERSHIP, AND BETTER UNDERSTAND HOW TO TREAT HUMAN DISEASES. THIS YEAR, THE CENTER RECRUITED THREE HIGHLY SOUGHT-AFTER EARLY-STAGE INVESTIGATORS INCLUDING: DR. GAMZE GURSOY BEGAN HER INDEPENDENT RESEARCH CAREER AT NYGC WITH A JOINT APPOINTMENT IN THE COLUMBIA UNIVERSITY DEPARTMENTS OF BIOMEDICAL INFORMATICS AND COMPUTER SCIENCE. SHE BRINGS A DIVERSE BACKGROUND INCLUDING HER INTEREST IN DEVELOPING TOOLS TO ANALYZE AND UNDERSTAND THE RELATIONSHIP BETWEEN GENOMIC STRUCTURE, VARIATION, AND MOLECULAR PHENOTYPES ASSOCIATED WITH DISEASES AND ADDING PRIVACY-PRESERVATION TO THESE MODELS AND DATASETS TO ENABLE INFERENCE FROM SENSITIVE GENOTYPIC AND PHENOTYPIC DATA WHILE PRESERVING PATIENT PRIVACY. AS A POSTDOC, DR. GURSOY WAS AWARDED A HIGHLY COMPETITIVE AND PRESTIGIOUS NIH/K99 "PATHWAY TO INDEPENDENCE AWARD" IN 2020 FROM THE NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI). CHENXU ZHU, PHD, IS A "MULTIOMICS" RESEARCHER AND HIS LAB FOCUSES ON APPLYING AN ARRAY OF INNOVATIVE GENOMIC METHODS, INCLUDING SINGLE-CELL TECHNOLOGIES, TO BETTER UNDERSTAND GENE REGULATION MECHANISMS IN HUMAN DEVELOPMENT AND DISEASE, PARTICULARLY CANCER. HE JOINED NYGC FROM THE SAN DIEGO BRANCH OF THE LUDWIG INSTITUTE FOR CANCER RESEARCH, WHERE HE SERVED AS A POSTDOCTORAL FELLOW IN ITS LABORATORY OF GENE REGULATION. DR. ZHU OBTAINED HIS PHD IN BIOCHEMISTRY AND MOLECULAR BIOLOGY FROM PEKING UNIVERSITY. HE ALSO HOLDS A JOINT APPOINTMENT AS ASSISTANT PROFESSOR AT NYGC MEMBER INSTITUTION WEILL CORNELL MEDICINE (WCM) IN THE DEPARTMENT OF PHYSIOLOGY AND BIOPHYSICS AND INSTITUTE FOR COMPUTATIONAL BIOMEDICINE. SANJA VICKOVIC, PHD, JOINED NYGC AS A CORE FACULTY MEMBER AND DIRECTOR OF NYGC'S TECHNOLOGY INNOVATION LAB. DR. VICKOVIC WORKED AT THE BROAD INSTITUTE OF MIT AND HARVARD, WHERE SHE WAS A WALLENBERG FELLOW IN DR. AVIV REGEV'S LAB. SHE OBTAINED HER PHD IN GENE TECHNOLOGY FROM THE KTH ROYAL INSTITUTE OF TECHNOLOGY, STOCKHOLM. DR. VICKOVIC IS AN EXPERIENCED AND ACCOMPLISHED ENGINEER AND AN INVENTOR OF THE SPATIAL TRANSCRIPTOMIC TECHNOLOGY CALLED "VISIUM" NOW COMMERCIALIZED BY 10X GENOMICS. SHE ALSO HAS TRAINING AND EXPERIENCE IN MATHEMATICS AND BIOLOGICAL SCIENCES. DR. VICKOVIC CURRENTLY HOLDS MULTIPLE JOINT APPOINTMENTS WHILE AT NYGC. SHE IS AN ASSISTANT PROFESSOR AT THE FU FOUNDATION SCHOOL OF ENGINEERING AND APPLIED SCIENCE AND THE HERBERT AND FLORENCE IRVING INSTITUTE FOR CANCER DYNAMICS AT COLUMBIA UNIVERSITY, AS WELL AS REMAINING A WALLENBERG ACADEMY FELLOW OF THE ROYAL SWEDISH ACADEMY OF SCIENCES AND THE ROYAL SWEDISH ACADEMY OF ENGINEERING SCIENCES AT UPPSALA UNIVERSITY. IN 2021, NYGC SCIENTISTS RECEIVED PRESTIGIOUS AWARDS FOR THEIR CONTRIBUTIONS TO PIONEERING RESEARCH, RELEASED FINDINGS FROM NEW STUDIES, AND DEVELOPED NEW GENOMIC TOOLS AND TECHNOLOGIES TO HELP ADVANCE PRECISION MEDICINE: DAN LANDAU, MD, PHD, RECEIVED A 2021 TOP 10 CLINICAL RESEARCH ACHIEVEMENT AWARD FOR HIS LAB'S BREAKTHROUGH TRANSLATIONAL RESEARCH IN DEVELOPING A HIGHLY SENSITIVE "LIQUID BIOPSY" BLOOD TEST FOR MONITORING OF CANCER PROGRESSION AND RELAPSE. DR. LANDAU ALSO LED THE TEAM THAT DEVELOPED A NEW MACHINE LEARNING TECHNIQUE THAT ANALYZES THE THOUSANDS OF DNA METHYLATION CHANGES DETECTED IN TUMOR CELLS -- AND INFERS WHICH ONES ARE LIKELY TO DRIVE TUMOR GROWTH. MARCIN IMIELINSKI, MD, PHD, IS AN AWARDEE OF THE 2021 PERSHING SQUARE SOHN PRIZE FOR YOUNG INVESTIGATORS IN CANCER RESEARCH. THE AWARD IS TO SUPPORT HIS PROJECT TO EXPLAIN WHY CERTAIN ACRAL MELANOMAS (WHICH OCCUR ON THE HANDS AND FEET) AND OTHER SIMILAR CANCERS WITH FEW SMALL MUTATIONS RESPOND TO IMMUNOTHERAPY BY EXAMINING A NOVEL CLASS OF GENETIC ALTERATIONS CALLED TYFONAS. THIS STUDY CAN TRANSFORM THE BASIC UNDERSTANDING OF CANCER EVOLUTION AND PROVIDE EVIDENCE FOR A WHOLE GENOME SEQUENCING IMMUNOTHERAPY BIOMARKER TO HELP NAVIGATE THE BEST COURSE FOR PATIENT TREATMENT. DR. IMIELINSKI ALSO LED THE MULTI-INSTITUTIONAL CANCER GENOMICS RESEARCH TEAM THAT RELEASED FINDINGS FROM A COMPREHENSIVE WHOLE-GENOME SEQUENCING STUDY OF A KEY SUBSET OF LUNG ADENOCARCINOMA (LUAD). THE TEAM'S REPORT DETAILS THEIR UNCOVERING OF STRUCTURAL GENETIC VARIANTS THAT MAY BE POTENTIAL NEW BIOMARKERS AND THERAPEUTIC TARGETS FOR LUAD, THE MOST COMMON LUNG MALIGNANCY AND A LEADING CAUSE OF CANCER DEATH IN THE U.S. RAHUL SATIJA, PHD, LED THE TEAM THAT DEVELOPED MIXSCAPE, A NEW COMPUTATIONAL TOOL TO INTERPRET EXPERIMENTS THAT COMBINE THE USE OF CRISPR TO PERTURB GENES ALONG WITH MULTIMODAL SINGLE-CELL SEQUENCING TECHNOLOGIES. THIS NEW TOOL HELPED TO IDENTIFY A NEW MOLECULAR MECHANISM FOR THE REGULATION OF IMMUNE CHECKPOINT PROTEINS THAT GOVERN THE IMMUNE SYSTEM'S ABILITY TO IDENTIFY AND DESTROY CANCER CELLS. NEVILLE SANJANA, PHD, RECEIVED A 2021 GRANT FROM THE SIMONS FOUNDATION (SFARI) TO SUPPORTS A PROJECT TO DEPLOY CRISPR AND OTHER TECHNOLOGIES TO UNCOVER BIOMARKERS FOR AUTISM GENE THERAPY. HEMALI PHATNANI, PHD IS A 2021 RECIPIENT OF THE NIH DIRECTOR'S TRANSFORMATIVE RESEARCH AWARD, PART OF THE NIH'S HIGH-RISK, HIGH-REWARD PROGRAM TO PROMOTE EXCEPTIONALLY INNOVATIVE OR UNCONVENTIONAL RESEARCH PROJECTS WITH THE POTENTIAL TO CREATE OR OVERTURN FUNDAMENTAL PARADIGMS. DR. PHATAMI WAS ALSO AWARDED A DEFENSE DEPT GRANT TO STUDY ALS-FRONTOTEMPORAL DEMENTIA. ADDITIONAL ACCOMPLISHMENTS IN 2021 INCLUDE: OVER THE PAST YEAR, NYGC HAS MADE GREAT PROGRESS IN CORE RESEARCH AREAS UNDER THE LEADERSHIP OF THE NEW YORK GENOME CENTER'S EVNIN FAMILY SCIENTIFIC DIRECTOR AND CEO, TOM MANIATIS. IN 2021, DR. MANIATIS WAS NAMED TO NEW YORK'S FIRST "CITY & STATE LIFE SCIENCES POWER 50" LIST, HIGHLIGHTING KEY INDIVIDUALS DRIVING THE LIFE SCIENCE SECTOR'S GROWTH IN NEW YORK. NYGC FACULTY PUBLISHED OVER 75 STUDIES IN HIGH-IMPACT SCIENTIFIC JOURNALS THAT PROVIDED NEW INSIGHTS INTO DISEASE MECHANISMS. NYGC RESEARCHERS HAVE DEVELOPED MANY INNOVATIVE GENOMIC TECHNOLOGIES AND NEW COMPUTATIONAL APPROACHES THAT ARE SHARED WIDELY WITH THE SCIENTIFIC COMMUNITY. CANCER: THE GENOME CENTER CANCER GROUP (GCCG), LED BY HAROLD VARMUS, MD, NYGC AND WEILL CORNELL MEDICINE, AND CHARLES SAWYERS, MD, MEMORIAL SLOAN KETTERING CANCER CENTER, IS COMPOSED OF CLINICIANS AND CANCER RESEARCHERS FROM NYGC'S MEMBER INSTITUTIONS, INCLUDING 10 NCI-DESIGNATED CANCER CENTERS. NYGC'S COLLABORATIVE CANCER INITIATIVE, POLYETHNIC-1000 (P-1000), WAS LAUNCHED IN 2018 TO ADVANCE CANCER GENOMICS IN UNDERREPRESENTED POPULATIONS. IN THE PAST YEAR, THE PROGRAM HAS APPOINTED TWO DISTINGUISHED CANCER AND ETHNICITY SCHOLARS, ONYINYE BALOGUN, MD, AND MELISSA B. DAVIS, PHD, ESTEEMED HEALTH DISPARITIES RESEARCHERS AT WEILL CORNELL MEDICINE WHO PROVIDE OVERSIGHT OF THE CONDUCT AND COORDINATION OF P-1000'S NEXT PHASE OF RESEARCH ACTIVITIES. DR. DAVIS RECENTLY AUTHORED A "SCIENCE & SOCIETY" ESSAY IN TRENDS IN CANCER. ADDITIONALLY, THE VERY RARE CANCER CONSORTIUM (VRCC) IS A RESEARCH COHORT FOCUSED ON UNDERSTANDING THE GENETIC CAUSES OF RARE, UNDERSTUDIED CANCERS AND LEVERAGES THE COMBINED EXPERTISE FROM INSTITUTIONS ACROSS NEW YORK CITY. THROUGH A NETWORK OF 20 MEMBER INSTITUTIONS, THIS PROJECT AIMS TO COLLECT SAMPLES OF VERY RARE CANCERS IN SUFFICIENT NUMBERS TO PROVIDE ANSWERS TO IMPORTANT SCIENTIFIC QUESTIONS, BUILD RESEARCH COHORTS, AND REDUCE THE TOLL TAKEN BY UNDERSTUDIED DISEASES. NEURODEGENERATIVE DISEASE: HEMALI PHATNANI, PHD, CORE FACULTY MEMBER AND DIRECTOR OF THE CENTER FOR GENOMICS OF NEURODEGENERATIVE DISEASE AT NYGC, CONVENED THE THIRD NYGC ALS CONSORTIUM BIANNUAL MEETING IN WHICH ONE HUNDRED RESEARCHERS AND CLINICIANS, FROM 40+ GLOBAL MEMBER INSTITUTIONS, SHARED THE LATEST IN ALS GENOMICS RESEARCH AND CELEBRATED MILESTONE ACCOMPLISHMENTS INCLUDING CREATING ONE OF THE LARGEST ALS DATA COHORTS IN THE WORLD, EMPOWERING AN INTEGRATED GLOBAL APPROACH TO ADVANCE NEW TREATMENTS AND EFFECTIVE THERAPIES FOR THIS COMPLEX DISEASE.
FORM 990, PART III, LINE 4A	NEUROPSYCHIATRIC DISEASE: DR. THOMAS LEHNER, NYGC'S SCIENTIFIC DIRECTOR FOR NEUROPSYCHIATRIC DISEASE, LEADS NYGC'S NEUROPSYCHIATRIC DISEASE SCIENTIFIC WORKING GROUP. A KEY PROJECT THE GROUP IS DEVELOPING IS GEMMA (GENOMIC MEDICINE FOR MENTAL HEALTH AVANCEMENT). GEMMA IS A NEW YORK STATE-WIDE PRECISION PSYCHIATRY PLATFORM THAT INTEGRATES DIAGNOSTIC, DEMOGRAPHIC, AND PATIENT CARE DATA WITH GENOMIC DATA AND OTHER MEDICAL RECORDS FOR SCIENTIFIC DISCOVERY, CLINICAL VALIDATION, AND TRANSLATIONAL IMPLEMENTATION. THIS UNPRECEDENTED RESOURCE WOULD RAPIDLY DEEPEN THE KNOWLEDGE BASE OF DIVERSE BIOMARKERS AND GENETIC FACTORS DRIVING NEUROPSYCHIATRIC DISEASE ENABLING A TRANSFORMATIVE EXPANSION OF THE PREDICTIVE AND DIAGNOSTIC VALUE OF GENOMIC TESTS, CLINICALLY ACTIONABLE FINDINGS, THERAPEUTIC DEVELOPMENT, AND PERSONALIZED TREATMENT GUIDELINES BASED ON INDIVIDUAL GENETIC MAKEUP AND MACHINE LEARNING-BASED DATA MINING WHICH WILL VASTLY IMPROVE PATIENT EXPERIENCE AND OUTCOMES. NYGC CHIEF DIAGNOSTIC OFFICER VAIDEHI JOBANPUTRA, PHD, FACMG, IS A MEMBER OF THE INVESTIGATIVE TEAM THAT CONDUCTED WHOLE GENOME SEQUENCING ANALYSIS OF 200+ FAMILIES THAT INCLUDED INDIVIDUALS WITH SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDERS. BASED ON THEIR ANALYSIS, THE TEAM IDENTIFIED MORE FINELY TARGETED DIAGNOSES FOR MANY OF THESE INDIVIDUALS, AS WELL AS UNCOVERED BIOMARKERS REGARDING TOLERANCE/RESISTANCE TO ANTIPSYCHOTIC TREATMENTS. THE TEAM NOTES THAT WHOLE GENOME SEQUENCING CAN PLAY A POWERFUL ROLE IN THE SETTING OF BOTH RESEARCH AND GENETIC COUNSELING FOR INDIVIDUALS WITH SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDERS AND THEIR FAMILIES. THE STUDY, DRAWING FROM PARTICIPANTS AROUND THE GLOBE, WAS PUBLISHED IN MOLECULAR PSYCHIATRY IN 2021. COVID-19: IN 2020, NYGC ESTABLISHED THE COVID-19 GENOMICS RESEARCH NETWORK (CGRN), A MULTIDISCIPLINARY CONSORTIUM TO SUPPORT GLOBAL COVID-19 GENOMICS RESEARCH COLLABORATION AND BUILD AN INFORMATION-SHARING DATABASE. THIS RESOURCE HELPS SUPPORT THE ONGOING EFFORTS TO IMPROVE THE TREATMENT OF PATIENTS AND BETTER UNDERSTAND THE EVOLUTION OF THE VIRUS, AS WELL AS THE LONG-TERM IMPACT ON POPULATION HEALTH. ADDITIONALLY, NYGC'S CLINICAL LABORATORY CONDUCTED COVID-19 TESTING FOR VARIOUS HEALTHCARE ENTITIES AND THE RESEARCH STAFF CONTRIBUTED TO VIRAL SURVEILLANCE EFFORTS THROUGHOUT NEW YORK AND NEW JERSEY WITH THE GOAL OF IDENTIFYING NEW VIRAL VARIANTS THAT INCREASE THE SPREAD OF THE PATHOGEN. THESE EFFORTS RESULTED IN SEVERAL PUBLICATIONS. CLINICAL LABORATORY: NYGC'S CLINICAL LABORATORY HAS LENT ITS INFRASTRUCTURE AND EXPERTISE TO SEVERAL LARGE INITIATIVES IN CLINICAL GENOMICS, INCLUDING PARTNERING WITH ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI LED NYCKIDSEQ PROJECT AS PART OF THE NHGRI, NCI, AND NIMHD FUNDED CLINICAL SEQUENCING EVIDENCE-GENERATING RESEARCH (CSER) CONSORTIUM. THIS EFFORT PRIORITIZES GENOME SEQUENCING OF HISTORICALLY UNDERREPRESENTED PATIENT POPULATIONS TO IMPROVE CLINICAL OUTCOMES AND STUDY THE EFFECTIVENESS OF INTEGRATING GENOME SEQUENCING INTO CLINICAL CARE AND DEVELOP BEST PRACTICES FOR DISCOVERY, INTERPRETATION, RETURN OF RESULTS, AND HEALTHCARE UTILIZATION. IN ADDITION, THE NYGC CLINICAL LABORATORY IS CURRENTLY COLLABORATING WITH WEILL CORNELL MEDICINE, NEWYORK-PRESBYTERIAN HOSPITAL, AND ILLUMINA ON A PRECISION MEDICINE COLLABORATION IN CANCER, CARDIOLOGY, ENDOCRINOLOGY, AND NEUROLOGY TO ASSESS AND IMPROVE THE VALUE OF CLINICAL WHOLE GENOMES WITH AIMS OF RETURNING CLINICALLY ACTIONABLE RESULTS, INTEGRATING ELECTRONIC HEALTH RECORDS, DEVELOPING NOVEL POLYGENIC RISK SCORES, AND UNDERSTANDING THE ROLE OF GENETICS IN THERAPEUTIC RESPONSES. RESEARCH SEQUENCING ------------------- NYGC HAS ONE OF THE LARGEST VOLUME WHOLE GENOME SEQUENCING PROGRAMS IN NEW YORK. IN THE PAST SIX YEARS, NYGC'S SEQUENCING LABORATORY HAS SEQUENCED OVER 82,000 WHOLE GENOME SAMPLES. NYGC HAS FIVE NOVASEQ SYSTEMS SEQUENCERS, WITH THE CAPACITY TO SEQUENCE THOUSANDS OF GENOMES A YEAR. THIS STATE-OF-THE-ART SEQUENCING TECHNOLOGY ENABLES NYGC TO CONDUCT LARGE-SCALE GENOMICS PROJECTS WITH GREAT SPEED AND SAMPLE VOLUMES, AND TO EXPLORE THE GENOME IN MORE DEPTH WITH GREATER EFFICIENCY. NYGC'S RESEARCH SEQUENCING LAB, LED BY SOREN GERMER, PHD, SENIOR VICE PRESIDENT OF GENOME TECHNOLOGIES, PROCESSED MORE THAN 14,000 SAMPLES IN 2021, INCLUDING 4,552 WHOLE GENOME SEQUENCING SAMPLES (GERMLINE AND CANCER), 5,787 COVID VIRAL SAMPLES, 3,341 TRANSCRIPTOME (RNA) SEQUENCING SAMPLES. IN 2021 THE PRODUCTION SEQUENCING LAB WAS AWARDED NEW CONTRACTS FROM NHLBI FOR A TOTAL OF UP TO $5,640,230. NYGC ALSO PURCHASED TWO NEW SEQUENCING INSTRUMENTS IN 2021; ONE INSTRUMENT ADDS LONG READ CAPACITY TO THE CENTER'S SEQUENCING MENU, THE OTHER PROMISES SUBSTANTIALLY REDUCED REAGENT COSTS FOR HIGH-THROUGHPUT APPLICATIONS AND HAS CREATED A LOT OF EXCITEMENT IN THE GENOMICS COMMUNITY. AS ONE OF THE FEW EARLY ADOPTERS OF THIS TECHNOLOGY, NYGC IS WORKING INTENSIVELY TO ENABLE THIS TECHNOLOGY FOR A RANGE OF APPLICATIONS. IN 2021, NYGC CONTINUED TO EXPAND ITS OPERATIONAL FOCUS ON SINGLE-CELL GENOMICS, MAKING AVAILABLE TO THE RESEARCH COMMUNITY THROUGH FUNCTIONAL GENOMIC COLLABORATIONS NEW CUTTING-EDGE TECHNIQUES INVENTED IN THE CENTER'S INNOVATION LAB. THESE INCLUDE CITE-SEQ, ASAP-SEQ, DOGMA-SEQ AS WELL AS THE 10X MULTIOME ASSAY, TECHNIQUES THAT ALLOW SIMULTANEOUS MEASUREMENT IN THOUSANDS OF CELLS COMBINATIONS OF CELL SURFACE PROTEIN MARKERS, RNA ABUNDANCE AND CHROMATIN ACCESSIBILITY. THE CENTER'S TECHNOLOGY INNOVATION LABORATORY HAS COMPLETED SEVERAL PROJECTS AND IS GEARING UP TO SUPPORT MULTIPLE LARGE GRANTS IN WHICH THESE ASSAYS WILL BE APPLIED. IN ADDITION, THE LAB HAS IMPLEMENTED A NOVEL AMPLIFICATION FREE SINGLE CELL WHOLE GENOME SEQUENCING ASSAY THAT IS BEING USED IN A LARGE STUDY OF ESOPHAGEAL CANCER IN A COLLABORATION WITH COLUMBIA UNIVERSITY AND CAMBRIDGE UNIVERSITY.
FORM 990, PART III, LINE 4A	DIVERSITY, EQUITY, AND INCLUSION --------------------- IN 2020, NYGC LAUNCHED AN ORGANIZATION-WIDE DIVERSITY, EQUITY, AND INCLUSION INITIATIVE, AFFIRMING NYGC'S COMMITMENT TO TAKE ACTIONABLE STEPS TOWARD CREATING A COMMUNITY ENVIRONMENT THAT IS WELCOMING AND INCLUSIVE TO ALL REGARDLESS OF RACE, ETHNICITY, GENDER, SEXUAL ORIENTATION, PHYSICAL ABILITY, AGE, OR RELIGION. IN 2021, NYGC'S CROSS-FUNCTIONAL DIVERSITY, EQUITY AND INCLUSION (DEI) ADVISORY GROUP, WHOSE GOAL IS TO FOSTER AND PROMOTE DIVERSITY, EQUITY AND INCLUSION THROUGHOUT ALL ASPECTS OF NYGC'S WORK AND CULTURE, PROVIDED EDUCATION AND RESOURCES TO THE NYGC COMMUNITY TO RAISE AWARENESS OF INEQUALITY AND BIAS AND TO ENHANCE CULTURAL COMPETENCY. EXAMPLES INCLUDE BOOK CLUBS, ORGANIZATION-WIDE TRAINING ON ISSUES RELATED TO DIVERSITY AND INCLUSION, AND THE DEVELOPMENT OF A WORKPLACE CULTURE SURVEY. THE GROUP, IN CLOSE PARTNERSHIP WITH NYGC'S SENIOR TEAM, HAS SHOWCASED THE WORK AND SKILLS OF DIVERSE EMPLOYEES, STAFF, FACULTY AND TRAINEES, WITH MENTORSHIP CAREER PANELS, AND BY DEVELOPING WEB PAGES, ARTICLES AND COMMUNICATIONS ON DEI-RELATED TOPICS. IT IS ALSO WORKING TO PROMOTE AND SUPPORT AN INCLUSIVE RESEARCH AND TRAINING ENVIRONMENT, INCLUDING BY HOSTING AN INTERNSHIP PROGRAM FOR UNDER-REPRESENTED MINORITIES IN 2021. NYGC IS COMMITTED TO ADDRESSING SYSTEMIC RACISM AND INEQUALITIES IN SCIENCE AND IN THE WORKPLACE AND WILL CONTINUE TO EXPAND ITS WORK IN ALL OF THESE AREAS.
FORM 990, PART VI, SECTION A, LINE 6	AS OF DECEMBER 31, 2021, THE CENTER HAD A TOTAL OF 20 MEMBERS, CONSISTING OF 12 INSTITUTIONAL FOUNDING MEMBERS AND EIGHT ASSOCIATE MEMBERS. THE INSTITUTIONAL FOUNDING MEMBERS ARE THE FOLLOWING RECOGNIZED ACADEMIC, MEDICAL AND RESEARCH INSTITUTIONS: (1) COLD SPRING HARBOR LABORATORY, (2) CORNELL UNIVERSITY/WEILL CORNELL MEDICINE, (3) THE JACKSON LABORATORY, (4) MEMORIAL SLOAN-KETTERING CANCER CENTER, (5) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, (6) NEW YORK-PRESBYTERIAN HOSPITAL, (7) NEW YORK UNIVERSITY, SCHOOL OF MEDICINE, (8) NORTHWELL HEALTH, (9) THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, ON BEHALF OF STONY BROOK UNIVERSITY, (10) THE ROCKEFELLER UNIVERSITY, (11) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, AND (12) ALBERT EINSTEIN COLLEGE OF MEDICINE. ASSOCIATE MEMBERS: (1) AMERICAN MUSEUM OF NATURAL HISTORY, (2) HOSPITAL FOR SPECIAL SURGERY, (3) THE NEW YORK STEM CELL FOUNDATION, (4) ROSWELL PARK CANCER INSTITUTE, (5) PRINCETON UNIVERSITY, (6) HACKENSACK MERIDIAN HEALTH, (7) GEORGETOWN LOMBARDI COMPREHENSIVE CANCER CENTER, AND (8) RUTGERS CANCER INSTITUTE OF NEW JERSEY.
FORM 990, PART VI, SECTION A, LINE 7A	EACH INSTITUTIONAL FOUNDING MEMBER APPOINTS ONE REPRESENTATIVE TO SERVE ON NYGC'S BOARD OF DIRECTORS. THE BOARD OF DIRECTORS ALSO INCLUDES THE SCIENTIFIC DIRECTOR AND OTHER DESIGNATED DIRECTORS OR INDIVIDUALS APPOINTED BY THE BOARD. DECISIONS REQUIRING BOARD APPROVAL INCLUDE THE ADMISSION OF NEW MEMBERS, CHANGES TO THE MISSION, CERTIFICATE OF INCORPORATION, AND BYLAWS, APPOINTMENT OR REMOVAL OF THE CHAIRPERSON OF THE BOARD AND THE SCIENTIFIC DIRECTOR, AND ADOPTION OF CERTAIN POLICIES AND PROCEDURES. THE BOARD ALSO REVIEWS AND APPROVES THE ANNUAL OPERATING BUDGET. MANAGEMENT HAS THE ABILITY TO ENTER INTO BUSINESS ARRANGEMENTS AND CONTRACTS, INCLUDING FINANCING ARRANGEMENTS AND HAS THE DISCRETION TO MAKE CERTAIN DECISIONS WITHOUT FORMAL BOARD APPROVAL.
FORM 990, PART VI, SECTION B, LINE 11B	THE FORM 990 IS PREPARED BY AN INDEPENDENT PUBLIC ACCOUNTING FIRM, UTILIZING INFORMATION PROVIDED BY MANAGEMENT. UPON RECEIPT OF THE DRAFT FORM 990, MANAGEMENT, INCLUDING THE CHIEF FINANCIAL OFFICER; DIRECTOR OF FINANCE; GENERAL COUNSEL; AND THE SCIENTIFIC DIRECTOR/CEO REVIEW THE FORM. PRIOR TO FILING, MANAGEMENT PRESENTS THE FORM 990 TO THE AUDIT COMMITTEE OF THE BOARD FOR REVIEW AND COMMENT. ALSO PRIOR TO FILING, MANAGEMENT PROVIDES THE FORM 990 TO THE ENTIRE BOARD OF DIRECTORS.
FORM 990, PART VI, SECTION B, LINE 12C	NYGC REQUIRES ALL INTERESTED PERSONS (DEFINED AS BOARD MEMBERS, OFFICERS, AND KEY EMPLOYEES) TO DISCLOSE CONFLICTS OF INTEREST AS REQUIRED BY THE CONFLICT OF INTEREST POLICY. NYGC FOLLOWS A PROCEDURE FOR OBTAINING SUCH DISCLOSURES ANNUALLY. ANY POTENTIAL CONFLICTS OF INTEREST DISCLOSED BY BOARD MEMBERS OR OFFICERS MUST BE REVIEWED BY THE BOARD. IF AN INTERESTED PERSON HAS A POTENTIAL CONFLICT OF INTEREST, HE OR SHE MAY PRESENT INFORMATION RELEVANT TO THE CONFLICT OF INTEREST OR UNDERLYING TRANSACTION AT A BOARD OR COMMITTEE MEETING, BUT AFTER SUCH PRESENTATION, HE/SHE SHALL LEAVE THE MEETING DURING THE DISCUSSION OF, AND THE VOTE ON, THE TRANSACTION OR ARRANGEMENT THAT CREATES THE POTENTIAL CONFLICT OF INTEREST.
FORM 990, PART VI, SECTION B, LINE 15	FOR THE ORGANIZATION'S TOP MANAGEMENT OFFICIAL, PLEASE REFER TO SCHEDULE J NARRATIVES FOR THE PROCESS OF DETERMINING COMPENSATION. FOR 2021, NYGC HIRED AN INDEPENDENT, OUTSIDE COMPENSATION CONSULTANT TO PERFORM AN ANALYSIS OF SENIOR MANAGEMENT'S TOTAL COMPENSATION. THE REVIEW SHOWED THAT THE COMPENSATION PAID TO MEMBERS OF SENIOR MANAGEMENT (CHERYL MOORE, CAROL ASHE, SOREN GERMER, ELIZABETH O'BRIEN, MICHAEL ZODY, THOMAS LEHNER AND TOM MANIATIS) WAS REASONABLE. THE AD-HOC COMPENSATION COMMITTEE OF THE BOARD (WHICH IS COMPOSED OF INDEPENDENT BOARD MEMBERS) MET WITH THE OUTSIDE CONSULTANT AT A COMMITTEE MEETING HELD IN JANUARY 2021 AND APPROVED THE 2021 COMPENSATION TO BE PAID TO SENIOR MANAGEMENT. THE COMMITTEE DOCUMENTED ITS ACTIONS IN WRITTEN MEETING MINUTES. IN MID-2021, ACTING ON INFORMATION PROVIDED BY NYGC'S INDEPENDENT COMPENSATION CONSULTANT, NYGC INCREASED MICHAEL ZODY'S SALARY TO BRING IT CLOSER TO MARKET LEVELS. THIS SALARY CHANGE WAS REVIEWED AND APPROVED BY THE AD-HOC COMPENSATION COMMITTEE OF THE BOARD AND DOCUMENTED IN WRITING. IN MID-2021, CHARLES GAGNON WAS PROMOTED TO THE EXECUTIVE ROLE OF CHIEF INFORMATION OFFICER AND GIVEN A SALARY INCREASE. PRIOR TO HIS PROMOTION, NYGC OBTAINED AN INDEPENDENT COMPENSATION ANALYSIS FOR THE POSITION, CONFIRMING THAT HIS PROPOSED SALARY INCREASE WAS REASONABLE. THE INDEPENDENT COMPENSATION ANALYSIS WAS REVIEWED BY THE AD-HOC COMPENSATION COMMITTEE OF THE BOARD, WHICH APPROVED MR. GAGNON'S SALARY AND DOCUMENTED ITS DECISION IN WRITING. IN OCTOBER 2021, SARAH LESSER AVINS WAS HIRED INTO THE EXECUTIVE ROLE OF SENIOR VICE PRESIDENT, ADVANCEMENT. PRIOR TO MS. AVINS HIRE, NYGC OBTAINED AN INDEPENDENT COMPENSATION ANALYSIS FOR THE POSITION CONFIRMING THAT HER PROPOSED TOTAL COMPENSATION WAS REASONABLE. THE INDEPENDENT COMPENSATION ANALYSIS WAS REVIEWED BY THE AD-HOC COMPENSATION COMMITTEE OF THE BOARD, WHICH APPROVED MS. AVINS COMPENSATION AND DOCUMENTED ITS DECISION IN WRITING. THE SENIOR MANAGEMENT TEAM RECEIVED STANDARD MERIT INCREASES IN 2021.
FORM 990, PART VI, SECTION C, LINE 19	NYGC'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST.
FORM 990, PART VII, SECTION A	IN 2021, TOM MANIATIS, PHD., SCIENTIFIC DIRECTOR & CEO, WAS EMPLOYED BY AN UNRELATED ENTITY AND LEASED TO NYGC TO DEVOTE 80% OF HIS TIME AND EFFORT TO SERVING AS NYGC'S SCIENTIFIC DIRECTOR AND CEO, AN OFFICER OF THE CORPORATION, AND AN ASSOCIATE MEMBER OF NYGC'S FACULTY, WITH RESPONSIBILITY FOR OVERSEEING NYGC'S RESEARCH PROGRAMS AND FOR UNDERTAKING SUCH OTHER ACTIVITIES AS NYGC'S BOARD OF DIRECTORS REQUESTED FROM TIME TO TIME. DR. MANIATIS DEVOTES 20% OF HIS TIME TO HIS DUTIES AT THE UNRELATED ENTITY, WHERE HE MAINTAINS A LABORATORY AND CONDUCTS INDEPENDENT, INVESTIGATOR-INITIATED RESEARCH PROJECTS.

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 51056K

Schedule O (Form 990) 2021

Additional Data

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1	Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
2	Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
3	Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
4	Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .	Yes	No
5	Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
6	Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No