TY 2021 Form 990

- TIN:

Form990

Department of the TreasuryInternal Revenue Service

Return of Organization Exempt From Income Tax

Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)

Do not enter social security numbers on this form as it may be made public.

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

A For the 2021 calendar year, or tax year beginning 01-01-2021 , and ending 12-31-2021

BCheck if applicable: Address change Name change Initial return Final return/terminated Amended return Application pending

CName of organization
MAYO CLINIC

Doing business as

Number and street (or P.O. box if mail is not delivered to street address)
200 FIRST STREET SW TAX

Room/suite

City or town, state or province, country, and ZIP or foreign postal code
ROCHESTER, MN55905

D Employer identification number

41-6011702

E Telephone number

G Gross receipts $ 13,663,012,552

F Name and address of principal officer:
GIANRICO FARRUGIA MD
200 FIRST STREET SW TAX
ROCHESTER,MN55905

Tax-exempt status: 501(c)(3) 501(c) ( ) LeftBullet

(insert no.) 4947(a)(1) or 527

Website:

WWW.MAYOCLINIC.ORG

H(a)

Is this a group return for
subordinates? Yes No

H(b)

Are all subordinates
included?

Yes No

If "No," attach a list. See instructions.

H(c)

Group exemption number MediumBullet

5983

K Form of organization: Corporation Trust Association Other MediumBullet

L Year of formation: 1919

M State of legal domicile: MN

Part I

Summary

1	Briefly describe the organization’s mission or most significant activities: PATIENT CARE, RESEARCH AND EDUCATION
2	Check this box
3	Number of voting members of the governing body (Part VI, line 1a) ........	3	28
4	Number of independent voting members of the governing body (Part VI, line 1b) .....	4	16
5	Total number of individuals employed in calendar year 2021 (Part V, line 2a) ......	5	27,619
6	Total number of volunteers (estimate if necessary) .............	6	653
7a	Total unrelated business revenue from Part VIII, column (C), line 12 ........	7a	950,291,461
b	Net unrelated business taxable income from Form 990-T, Part I, line 11 .........	7b	162,044,886

		Prior Year	Current Year
8	Contributions and grants (Part VIII, line 1h) .........	2,422,520,612	2,825,326,266
9	Program service revenue (Part VIII, line 2g) .........	3,743,006,635	4,089,305,003
10	Investment income (Part VIII, column (A), lines 3, 4, and 7d ) ....	494,073,596	1,021,883,730
11	Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e)	40,499,808	56,726,005
12	Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)	6,700,100,651	7,993,241,004
13	Grants and similar amounts paid (Part IX, column (A), lines 1–3 )...	517,707,005	540,559,805
14	Benefits paid to or for members (Part IX, column (A), line 4).....	0	0
15	Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10)	2,713,116,544	2,842,196,781
16a	Professional fundraising fees (Part IX, column (A), line 11e) .....	513,347	617,878
b	Total fundraising expenses (Part IX, column (D), line 25) 45,604,347
17	Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e)....	2,306,475,790	2,389,744,925
18	Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25)	5,537,812,686	5,773,119,389
19	Revenue less expenses. Subtract line 18 from line 12.......	1,162,287,965	2,220,121,615
		Beginning of Current Year	End of Year
20	Total assets (Part X, line 16).............	16,528,218,881	20,543,802,362
21	Total liabilities (Part X, line 26).............	10,991,681,283	10,166,049,837
22	Net assets or fund balances. Subtract line 21 from line 20.....	5,536,537,598	10,377,752,525

Part II

Signature Block

Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.

Sign Here

	Signature of officer	Date

	Type or print name and title

Paid Preparer Use Only

Print/Type preparer's name

Preparer's signature

Date

Check if
self-employed

PTIN

Firm's name MediumBullet

Firm's EIN MediumBullet

Firm's address MediumBullet

Phone no.

May the IRS discuss this return with the preparer shown above? (see instructions) ..........YesNo

For Paperwork Reduction Act Notice, see the separate instructions.

Cat. No. 11282Y Form 990 (2021)

Form 990 (2021)

Page 2

Part III

Statement of Program Service Accomplishments

Check if Schedule O contains a response or note to any line in this Part III..............

Briefly describe the organization’s mission: TO INSPIRE HOPE AND CONTRIBUTE TO HEALTH AND WELL-BEING BY PROVIDING THE BEST CARE TO EVERY PATIENT THROUGH INTEGRATED CLINICAL PRACTICE, EDUCATION AND RESEARCH.

Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? ..................... Yes No

If "Yes," describe these new services on Schedule O.

Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ........................... Yes No

If "Yes," describe these changes on Schedule O.

Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.


4a	(Code: ) (Expenses $ 3,609,939,156 including grants of $ 473,885,845 ) (Revenue $ 4,092,205,968 )
	PATIENT CARE (SEE SCHEDULE O FOR DESCRIPTION)PATIENT CARE:MAYO CLINIC IS AN INTEGRATED, NOT-FOR-PROFIT MEDICAL GROUP PRACTICE. ITS STANDARD OF CARE BRINGS TOGETHER TEAMS OF EXPERTS TO PROVIDE HIGH-QUALITY, AFFORDABLE AND COMPASSIONATE CARE TO EACH PATIENT CONSISTENT WITH MAYO CLINIC'S PRIMARY VALUE - THE NEEDS OF THE PATIENT COME FIRST. MAYO CLINIC'S MISSION IS TO INSPIRE HOPE AND CONTRIBUTE TO HEALTH AND WELL-BEING BY PROVIDING THE BEST CARE TO EVERY PATIENT THROUGH INTEGRATED CLINICAL PRACTICE, EDUCATION AND RESEARCH. MAYO CLINIC'S HERITAGE OF COLLABORATIVE MEDICAL EXPERTISE IS COMBINED WITH CAREFUL ATTENTION TO INDIVIDUAL PATIENT NEEDS, RESULTING IN A THOROUGH AND PERSONAL APPROACH TO HEALTH CARE.PATIENT CARE ADVANCED THROUGH EDUCATION AND RESEARCH IS THE FOUNDATION OF MAYO CLINIC'S MISSION. TO ACCOMPLISH ITS MISSION, MAYO CLINIC NOT ONLY PROVIDES A VARIETY OF PROGRAMS IN DIRECT PATIENT CARE, MEDICAL EDUCATION AND RESEARCH, BUT ALSO SERVES AS THE PARENT ORGANIZATION OF A MULTI-ENTITY ORGANIZATION CONSISTING OF HOSPITALS, CLINICS, HEALTH CARE PROVIDERS AND OTHER ENTITIES PROVIDING HEALTH CARE-RELATED SERVICES AND KNOWLEDGE DELIVERY TO THE PUBLIC THROUGHOUT THE WORLD. IN ROCHESTER, MAYO CLINIC WORKS COLLABORATIVELY WITH MAYO CLINIC HOSPITAL - ROCHESTER, AN AFFILIATED ENTITY COMPRISED OF SAINT MARYS CAMPUS AND METHODIST CAMPUS TO FORM AN INTEGRATED MEDICAL CENTER DEDICATED TO PROVIDING COMPREHENSIVE DIAGNOSIS AND TREATMENT IN VIRTUALLY EVERY MEDICAL AND SURGICAL SPECIALTY.MAYO CLINIC IS ALSO THE SOLE MEMBER OF MAYO CLINIC ARIZONA AND MAYO CLINIC JACKSONVILLE WHICH PROVIDE SERVICES TO PATIENTS IN THE SOUTHWEST AND SOUTHEAST REGIONS OF THE UNITED STATES. IN THE MIDWEST, MAYO CLINIC HEALTH SYSTEM SERVES COMMUNITIES IN MINNESOTA, WISCONSIN, AND IOWA THROUGH A NETWORK OF COMMUNITY-BASED PHYSICIANS TO PROVIDE QUALITY HEALTH CARE CLOSE TO HOME, AND ALSO SUPPORTED BY THE HIGHLY SPECIALIZED EXPERTISE AND RESOURCES OF MAYO CLINIC.UTILIZING COMMON GOVERNANCE, SHARED SYSTEMS AND STANDARDIZED POLICIES AND PROCEDURES WHENEVER POSSIBLE, MAYO CLINIC STRIVES TO PROVIDE CONSISTENT, HIGH QUALITY HEALTH CARE SERVICES AND KNOWLEDGE DELIVERY WITHIN EVERY ASPECT OF CARE. A 31-MEMBER BOARD OF TRUSTEES COMPRISED OF A MAJORITY OF PUBLIC MEMBERS ALONG WITH MAYO PHYSICIANS AND ADMINISTRATORS ENSURE THE ENTIRE ORGANIZATION REMAINS TRUE TO ITS MISSION AND CULTURE OF PROVIDING FOR THE HEALTH CARE NEEDS OF THE PUBLIC RATHER THAN FOR PRIVATE BENEFIT. MAYO CLINIC HAS REINFORCED ITS LEADERSHIP IN PATIENT CARE, RESEARCH AND EDUCATION TO DRIVE FORWARD THE TRANSFORMATION OF HEALTH CARE OVER THE NEXT DECADE. WITH DIGITAL INNOVATIONS AND NEW TECHNOLOGIES, MAYO CLINIC IS MOVING QUICKLY TO EXTEND ITS COMPASSIONATE CARE, EXPERTISE AND RESEARCH, AND IS REINVESTING IN PEOPLE AND FACILITIES IN THE COMMUNITIES IT SERVES. MAYO CLINIC HAS ACCELERATED ITS INVESTMENT IN THE DIGITAL TRANSFORMATION OF HEALTH CARE, AS PART OF ITS 2030 STRATEGY TO TRANSFORM PATIENT AND CLINICIAN EXPERIENCES AND SOLVE HUMANITY'S MOST COMPLEX MEDICAL CHALLENGES. MAYO CLINIC REMAINS TOP-RANKED IN QUALITY MORE THAN ANY OTHER HEALTH CARE ORGANIZATION BY INDEPENDENT GROUPS, SUCH AS THE NURSING MAGNET RECOGNITION PROGRAM, PRESS GANEY PATIENT EXPERIENCE AWARDS, THE CENTERS FOR MEDICARE & MEDICAID SERVICES OVERALL HOSPITAL QUALITY STAR RATINGS, LEAPFROG HOSPITAL SAFETY SURVEY AND THE AMERICAN COLLEGE OF SURGEONS NATIONAL SURGICAL QUALITY IMPROVEMENT PROGRAM. FOR THE 2021-2022 PERIOD, MAYO CLINIC WAS AGAIN RANKED AS HAVING THE NO. 1 HOSPITAL IN THE NATION (MAYO CLINIC HOSPITAL-ROCHESTER) AND TOP-RANKED IN 14 SPECIALTIES BY U.S. NEWS & WORLD REPORT.MAYO CLINIC OFFERS BOTH SPECIALTY AND PRIMARY CARE IN ITS COMMUNITY PRACTICES AND MAINTAINS A POPULATION HEALTH OFFICE. IT IS THE CHARGE OF MAYO'S POPULATION HEALTH COMMITTEE TO TRANSFORM THE WAY COMMUNITY CARE IS DELIVERED AND IMPROVE PATIENT OUTCOMES WHILE REDUCING THE OVERALL TOTAL COST OF CARE. POPULATION HEALTH AT MAYO COORDINATES EXISTING PRACTICE MODELS WITH TRANSFORMATIONAL INITIATIVES TO BETTER ENGAGE PATIENTS, KEEP THEM HEALTHY, SUPPORT PATIENT WELLNESS GOALS AND HELP PATIENTS TO BETTER MANAGE CHRONIC ILLNESSES. THE PRACTICE CHANGE INITIATIVES DEVELOPED, TESTED AND IMPLEMENTED THROUGH THE MAYO MODEL OF COMMUNITY CARE (MMOCC) ARE AIMED AT IMPROVING THE QUALITY OF LIFE FOR PATIENTS, REDUCING OVERALL HEALTH CARE COSTS AND BUILDING A SUSTAINABLE PRACTICE MODEL THAT TRULY SUPPORTS THE NEEDS OF COMMUNITY PATIENTS.THROUGH MAYO CLINIC'S CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE, MAYO CLINIC COLLABORATES WITH DIVERSE COMMUNITY MEMBERS TO HELP COMMUNITY MEDICAL PROVIDERS INCORPORATE PRACTICE-BASED AND RESEARCH-BASED KNOWLEDGE TO IMPROVE OVERALL COMMUNITY HEALTH OUTCOMES AND ELIMINATE HEALTH DISPARITIES. EACH YEAR, PEOPLE FROM ALL 50 STATES AND APPROXIMATELY 139 COUNTRIES COME TO MAYO CLINIC FOR CARE. DURING 2021, MAYO CLINIC PROVIDED SERVICES TO APPROXIMATELY 473,000 OUTPATIENT VISITORS. TOTAL PATIENT VISITS FOR MAYO CLINIC AND ITS AFFILIATES DURING 2021 WERE APPROXIMATELY 1.4 MILLION. MAYO CLINIC PROVIDES CARE TO PEOPLE COVERED BY GOVERNMENTAL PROGRAMS SUCH AS MEDICARE AND MEDICAID, AT SUBSTANTIAL DISCOUNTS FROM STANDARD FEES. CHARITY CARE IS ALSO PROVIDED FOR PATIENTS THAT ARE FINANCIALLY UNABLE TO PAY FOR SERVICES PROVIDED. IN 2021, THE COST OF UNCOMPENSATED CARE PROVIDED THROUGH MEDICAID AND MINNESOTA CARE (A PROGRAM THAT PROVIDES MEDICAL ASSISTANCE FOR LOW INCOME POPULATIONS) WAS APPROXIMATELY $262,500,000. THIS AMOUNT INCLUDES APPROXIMATELY $41,900,000 PAID TO MINNESOTACARE. THE COST OF UNCOMPENSATED CARE PROVIDED THROUGH MEDICARE WAS APPROXIMATELY $1,122,400,000 AND THE COST OF CHARITY CARE PROVIDED IN 2021 WAS APPROXIMATELY $13,500,000.IN 2021, WITH SYSTEM-WIDE REVENUES OF $15.7 BILLION, MAYO CLINIC AND ITS AFFILIATES PROVIDED $650 MILLION IN CARE TO PEOPLE IN NEED. THIS TOTAL INCLUDES $49 MILLION IN CHARITY CARE AND $601 MILLION IN UNPAID PORTIONS OF MEDICAID AND OTHER INDIGENT CARE PROGRAMS FOR PEOPLE WHO ARE UNINSURED OR UNDERINSURED. MAYO ALSO PROVIDED $2.6 BILLION IN UNPAID PORTIONS OF MEDICARE AND OTHER SENIOR PROGRAMS. APPROXIMATELY 56 PERCENT OF MAYO'S TOTAL MEDICAL SERVICES PROVIDED ARE FOR MEDICARE AND MEDICAID PATIENTS. MAYO CLINIC AND ITS AFFILIATES CONTRIBUTED MORE THAN $13 MILLION IN CASH AND IN-KIND DONATIONS TO LOCAL COMMUNITIES. THE MAYO CLINIC CARE NETWORK CONSISTS OF INDEPENDENT HEALTH-CARE ORGANIZATIONS THAT SHARE A COMMON GOAL OF IMPROVING DELIVERY OF HEALTH CARE IN THEIR COMMUNITIES THROUGH HIGH-QUALITY, DATA DRIVEN AND EVIDENCE BASED MEDICAL CARE. MEMBERS OF THE NETWORK HAVE ACCESS TO MAYO CLINIC KNOWLEDGE, COLLABORATION TOOLS, DISEASE MANAGEMENT PROTOCOLS, CLINICAL CARE GUIDELINES, TREATMENT RECOMMENDATIONS, PATIENT EDUCATION MATERIALS AND CONTINUING MEDICAL EDUCATION OPPORTUNITIES. THE MAIN GOAL OF THE NETWORK IS TO HELP PEOPLE GAIN THE BENEFITS OF MAYO CLINIC EXPERTISE WITHOUT HAVING TO TRAVEL TO A MAYO CLINIC FACILITY. FOR 2021, THE MAYO CLINIC CARE NETWORK CONSISTED OF APPROXIMATELY 46 MEMBERS LOCATED IN THE UNITED STATES, CHINA, EGYPT, INDIA, MEXICO, SAUDI ARABIA, AND THE UNITED ARAB EMIRATES. THROUGH THE MAYO CLINIC CARE NETWORK, MORE THAN 15 MILLION PATIENTS AND CARE TEAMS HAVE ACCESS TO MAYO CLINIC KNOWLEDGE, CLINICAL PROTOCOLS AND CONSULTATIONS VIA MAYO'S CONNECTED CARE PLATFORM.HEALTH INFORMATION IS VIEWED AS AN IMPORTANT PART OF MAYO CLINIC'S PATIENT CARE MISSION. MAYO CLINIC, IN CONJUNCTION WITH ITS AFFILIATES, PROVIDES A VARIETY OF HEALTH INFORMATION RESOURCES (BOOKS, NEWSLETTER, ON-LINE CONTENT, ETC.) TO PATIENTS, CONSUMERS AND THE GENERAL PUBLIC.MAYO CLINIC'S SOCIAL MEDIA NETWORK IS A NETWORK OF HEALTH CARE ORGANIZATIONS, HOSPITALS AND MEDICAL PROFESSIONALS COMMITTED TO BROADER AND DEEPER ENGAGEMENT IN SOCIAL MEDIA TO HELP IMPROVE HEALTH CARE LITERACY, HEALTH CARE DELIVERY AND POPULATION HEALTH WORLDWIDE.MAYO CLINIC LIBRARIES REFLECT AN INTEGRATED SYSTEM OF LIBRARIES, KNOWLEDGE CENTERS AND ARCHIVES. THE BREADTH OF THESE RESOURCES AND THEIR INTEGRATION MAKES THE MAYO CLINIC LIBRARIES AMONG THE MOST COMPREHENSIVE IN NORTH AMERICA. THE LIBRARIES SUPPORT HOSPITALIZED PATIENTS AND THEIR FAMILIES, ALONG WITH SUPPORTING EMPLOYEES, RESEARCHERS, FACULTY AND STUDENTS IN THEIR CARE OF PATIENTS AND MEDICAL RESEARCH.COMMUNITY GIVING AND INVOLVEMENT IS A VALUE-DRIVEN PRIORITY AT MAYO CLINIC. QUALITY PATIENT CARE IS BEST ADVANCED WITHIN A VIBRANT LOCAL COMMUNITY, WITH STRONG SOCIETAL FOUNDATIONS, SUCH AS EDUCATION, HEALTH, INCLUSIVITY, A DIVERSE ECONOMY, SUPPORTIVE SOCIAL SERVICES, AND AMENITIES THAT MAKE ROCHESTER A DESIRABLE PLACE TO LIVE AND SUPPORT SOCIAL DETERMINANTS OF HEALTH. MAYO CLINIC'S COMMUNITY CONTRIBUTIONS PROGRAM PROVIDES FINANCIAL AND IN-KIND SUPPORT TO NON-PROFIT ORGANIZATIONS IN SUPPORT OF THESE EFFORTS.

4b	(Code: ) (Expenses $ 794,252,067 including grants of $ 41,207,067 ) (Revenue $ 26,082,394 )
	MEDICAL RESEARCH (SEE SCHEDULE O FOR DESCRIPTION)MEDICAL RESEARCH:MAYO CLINIC IS ONE OF THE PREMIER MEDICAL RESEARCH ORGANIZATIONS IN THE WORLD. INNOVATION AND IMPROVEMENT OF SCIENCE AND THE DELIVERY OF HEALTH CARE ARE ENHANCED THROUGH MAYO CLINIC'S RESEARCH PROGRAMS. CLINICAL PRACTICE OBSERVATIONS BECOME THE BASIS FOR RESEARCH STUDIES AND THE FINDINGS FROM RESEARCH FLOW BACK INTO THE PRACTICE TO IMPROVE PATIENT CARE AND OUTCOMES. PHYSICIAN/RESEARCHERS AND CAREER SCIENTISTS' WORK IN TANDEM TO ADVANCE MEDICINE AND TO IMPROVE THE HEALTH AND WELLBEING OF NOT JUST MAYO CLINIC PATIENTS, BUT ALSO THE PUBLIC AT LARGE, AS THESE FINDINGS ARE DISSEMINATED WORLDWIDE.RESEARCH AT MAYO CLINIC INVOLVES MEDICAL PROFESSIONALS COMMITTED TO SEARCHING FOR ANSWERS TO COMPLEX MEDICAL PROBLEMS WITH THE GOAL OF BRINGING NEW SOLUTIONS AND ADVANCED CARE RAPIDLY TO PATIENTS THROUGHOUT THE WORLD. RESEARCH ACTIVITIES INCLUDE BASIC SCIENCE RESEARCH, CLINICAL TRIALS, TRANSLATIONAL RESEARCH AND HUMAN RESEARCH STUDIES. DURING 2021, MAYO CLINIC, IN CONJUNCTION WITH ITS AFFILIATES, HAD OVER 4,550 RESEARCH PERSONNEL, 22 CORE LABORATORIES, OVER 9,300 ACTIVE INSTITUTIONAL REVIEW BOARD-APPROVED HUMAN RESEARCH STUDIES, OVER 5,380 NEW HUMAN RESEARCH STUDIES APPROVED BY THE INSTITUTIONAL REVIEW BOARD AND MORE THAN 13,690 RESEARCH AND REVIEW ARTICLES PUBLISHED IN PEER-REVIEWED JOURNALS. MANY OF THESE PERSONNEL, LABORATORIES, STUDIES AND ARTICLES ARE LOCATED OR PERFORMED BY MAYO CLINIC IN ROCHESTER, MINNESOTA.DURING 2021, DUE TO THE COVID-19 PANDEMIC, MAYO CLINIC CONTINUTED TO REFOCUS MUCH OF ITS RESEARCH EFFORTS TO BRING GREATER UNDERSTANDING, THERAPIES AND POTENTIAL VACCINE SOLUTIONS FOR THE COVID-19 VIRUS, INCLUDING ANTIBODY TESTING CAPABILITIES, BLOOD PLASMA THERAPIES AND EFFECTIVENESS AND SAFETY OF VARIOUS PHARMACEUTICAL THERAPIES.FUNDING OF RESEARCH ACTIVITIES AT MAYO CLINIC COMES FROM GRANTS AND CONTRACTS AS WELL AS FROM MAYO FUNDS AND GIFTS FROM GENEROUS BENEFACTORS.

4c	(Code: ) (Expenses $ 285,871,347 including grants of $ 25,466,892 ) (Revenue $ 9,035,989 )
	MEDICAL EDUCATION (SEE SCHEDULE O FOR DESCRIPTION)MEDICAL EDUCATION:MEDICAL EDUCATION, RESEARCH TRAINING, CONTINUOUS MEDICAL LIFE-LONG LEARNING AND A COMMITTED QUEST FOR NEW KNOWLEDGE ARE INTEGRAL FUNCTIONS OF MAYO CLINIC. OUR WORLD-RENOWNED EDUCATIONAL PROGRAMS INFORM, INSTRUCT, AND EMPOWER PHYSICIANS, RESEARCHERS, MEDICAL PROFESSIONALS, PATIENTS, STUDENTS AND OUR COMMUNITIES TO IMPROVE PUBLIC HEALTH AND WELL-BEING. THESE PROGRAMS SPAN THE CONTINUUM OF HEALTH CARE AND ENSURE THE MAYO MODEL OF CARE IS PERPETUATED AND SHARED BROADLY. MAYO CLINIC IS COMMITTED TO PROVIDING USEFUL, TIMELY KNOWLEDGE AND SKILLS THAT REFLECT ITS STANDARDS OF EXCELLENCE AND ITS DEDICATION TO FINDING ANSWERS FOR UNMET PATIENT NEEDS: EDUCATING THE NEXT GENERATION OF PHYSICIANS, MEDICAL RESEARCHERS AND HEALTH PROFESSIONALS WITH TRANSFORMATIVE CURRICULA THAT FOCUSES NOT ONLY ON HELPING THE PATIENT, BUT ALSO IMPROVING THE HEALTH CARE SYSTEM;SHARING KNOWLEDGE AND INNOVATIVE BEST PRACTICES FREELY IN THE SPIRIT OF COLLABORATION TO ADVANCE THE SCIENCE OF MEDICINE AND THE ART OF COMPASSIONATE, PATIENT-CENTERED CARE;EMPOWERING PEOPLE TO MANAGE THEIR HEALTH THROUGH PATIENT EDUCATION AND SHARED DECISION-MAKING MEDICAL TRAINING;SPREADING MAYO'S MEDICAL EXPERTISE, EDUCATION AND RESEARCH FINDINGS THROUGHOUT THE WORLD TO IMPROVE HEALTH CARE FOR ALL.WORKING COLLABORATIVELY AT A NATIONAL LEVEL TO MODERNIZE AND TRANSFORM MEDICAL EDUCATION TO ADDRESS AREAS SUCH AS IMPROVING HEALTH CARE DELIVERY, PHYSICIAN BURN-OUT, POPULATION HEALTH ISSUES, AND TEAM-BASED CARE. THE EDUCATIONAL ACTIVITIES OF MAYO CLINIC ARE CENTERED IN MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE'S FIVE SCHOOLS: 1. MAYO CLINIC SCHOOL OF GRADUATE MEDICAL EDUCATION IS ONE OF THE NATION'S OLDEST AND LARGEST SCHOOLS OF GRADUATE MEDICAL EDUCATION WITH ANNUAL ENROLLMENT OF APPROXIMATELY 1,800 RESIDENT AND FELLOW PHYSICIANS IN TRAINING. THE SCHOOL TRAINS DOCTORS IN OVER 300 RESIDENCY AND FELLOWSHIP PROGRAMS, REPRESENTING VIRTUALLY EVERY MEDICAL SPECIALTY. IN ADDITION, MANY GRADUATES COMPLETE MAYO CLINIC QUALITY ACADEMY TRAINING - A CONCERTED EFFORT TO EDUCATE AND PREPARE TRAINEES TO CONTINUOUSLY EXPLORE WAYS TO IMPROVE PATIENT SAFETY, QUALITY CARE AND ELIMINATE HEALTH DISPARITIES. 2. MAYO CLINIC ALIX SCHOOL OF MEDICINE PROVIDES A FOUR-YEAR MEDICAL EDUCATION PROGRAM LEADING TO DOCTOR OF MEDICINE DEGREES AND JOINT MD/PH.D. DEGREES. THE SCHOOL HAS ANNUAL ENROLLMENT OF APPROXIMATELY 460 STUDENTS ON THE ROCHESTER, MINNESOTA; SCOTTSDALE, ARIZONA; AND JACKSONVILLE, FLORIDA CAMPUSES.THE INNOVATIVE AND TRANSFORMATIVE CURRICULUM OF MAYO CLINIC ALIX SCHOOL OF MEDICINE FOCUSES ON EDUCATING FUTURE PHYSICIAN LEADERS IN PATIENT-CENTERED, SCIENCE-DRIVEN, TEAM-BASED, HIGH VALUE HEALTH CARE. STUDENTS ACROSS ALL CAMPUSES ARE SOME OF THE FIRST NATIONWIDE TO TRAIN AND FIRST NATIONWIDE TO RECEIVE A SCIENCE OF HEALTH CARE DELIVERY CERTIFICATE IN ADDITION TO A MEDICAL DEGREE. THE INTEGRATED, TRANSFORMATIVE CURRICULUM IS PART OF AN INITIATIVE TO BETTER PREPARE STUDENTS FOR THE CHALLENGES OF DELIVERING PATIENT CARE IN A COMPLEX HEALTH CARE ENVIRONMENT. ADDITIONAL OFFERINGS AT THE SCHOOL INCLUDE VISITING MEDICAL STUDENT CLERKSHIP PROGRAMS AND SUMMER MINORITY MEDICAL STUDENT PROGRAMS. THE SCHOOL CULTIVATES STUDENTS TO CONTINUALLY PURSUE NEW KNOWLEDGE THROUGH DISCOVERY, TRANSLATION AND CLINICAL APPLICATION TO MEET THE NEEDS OF THEIR PATIENTS.THE MAYO CLINIC ALIX SCHOOL OF MEDICINE STUDENTS WAS RANKED NO. 11 IN THE NATION FOR THE BEST MEDICAL SCHOOL FOR RESEARCH FOR THE 2021-2022 PERIOD BY U.S. NEWS & WORLD REPORT. 3. MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL SCIENCES HAS A DISTINGUISHED HISTORY OF PREPARING STUDENTS FOR CAREERS AS COMPETITIVE BIOMEDICAL RESEARCH INVESTIGATORS. THE SCHOOL OFFERS MASTER'S AND DOCTORAL DEGREE PROGRAMS FOCUSING ON EIGHT BIOMEDICAL SPECIALTIES, AS WELL AS ONE OF THE FIRST INTERDISCIPLINARY PROGRAMS IN REGENERATIVE MEDICAL RESEARCH. THE SCHOOL IS A PIONEER IN EXPANDING RESEARCH TRAINING OPPORTUNITIES FOR STUDENTS FROM BACKGROUNDS UNDERREPRESENTED IN RESEARCH, INCLUDING VISITING PRE-DOCTORAL AND SUMMER UNDERGRADUATE RESEARCH PROGRAMS WHERE DIVERSE STUDENTS HAVE THE OPPORTUNITY TO WORK WITH WORLD-RENOWNED RESEARCHERS AT MAYO CLINIC CAMPUSES IN ARIZONA, FLORIDA AND MINNESOTA. THE MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL SCIENCES HAS AN ANNUAL ENROLLMENT OF APPROXIMATELY 350 STUDENTS.4. MAYO CLINIC SCHOOL OF HEALTH SCIENCES PREPARES THE ALLIED HEALTH CARE WORKFORCE OF THE FUTURE IN PROGRAMS RANGING FROM A 10-MONTH PHLEBOTOMY CERTIFICATE PROGRAM TO A DOCTORATE IN PHYSICAL THERAPY OR NURSE ANESTHESIA. THE MAYO CLINIC SCHOOL OF HEALTH SCIENCES HAS AN ANNUAL ENROLLMENT OF APPROXIMATELY 1,600 STUDENTS. WITH CAMPUSES IN MINNESOTA, FLORIDA AND ARIZONA, THE SCHOOL PREPARES STUDENTS IN OVER 140 PROGRAMS REPRESENTING 50 HEALTH SCIENCE AREAS. THE SCHOOL ALSO PROVIDES CLINICAL INTERNSHIPS FOR HUNDREDS OF AFFILIATED SCHOOLS. APPROXIMATELY 480 FACULTY MEMBERS ENSURE EVERY STUDENT RECEIVES EXTENSIVE PERSONALIZED TRAINING. 5. MAYO CLINIC SCHOOL OF CONTINUOUS PROFESSIONAL DEVELOPMENT PROVIDES A COMPREHENSIVE SELECTION OF APPROXIMATELY 540 CLINICAL, SURGICAL, ALLIED HEALTH AND RESEARCH COURSES, AS WELL AS PROGRAMS ON HEALTH CARE ISSUES, PRACTICE MANAGEMENT AND LEADERSHIP, TO HEALTH CARE PROFESSIONALS THROUGHOUT THE WORLD. PARTICIPANTS INCLUDE MAYO AND NON-MAYO ATTENDEES. MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE ALSO HAS INITIATED MAYO CLINIC EDUCATION PLATFORMS TO DEVELOP AND DELIVER ONLINE EDUCATIONAL OPPORTUNITIES FOR BROAD DISTRIBUTION OF CONTINUING MEDICAL EDUCATION, FACULTY DEVELOPMENT, STUDENT EDUCATION AND FUTURE PATIENT EDUCATION. VIDEO SEMINARS AND ONLINE LEARNING MODULES PROVIDE CONSISTENT KNOWLEDGE DELIVERY ACROSS MULTI-SPECIALTIES AND ALLOW FOR MORE INTERACTIVE FACULTY/STUDENT PARTICIPATION IN THE CLASSROOM SETTING. ONLINE LEARNING ALSO FACILITATES THE ABILITY FOR MAYO CLINIC TO SHARE AND EXPAND THE LATEST MEDICAL KNOWLEDGE AND INNOVATIVE LEARNING OPPORTUNITIES WITH OTHERS OUTSIDE MAYO CLINIC.ANOTHER INITIATIVE IMPLEMENTED THROUGH MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE IS THE OFFICE OF APPLIED SCHOLARSHIP AND EDUCATION SCIENCE (OASES). THIS INNOVATIVE OFFICE PROVIDES EXPERTISE AND SUPPORT IN FACULTY DEVELOPMENT, EDUCATION EVALUATION AND PRINCIPLES AND PRACTICES OF EDUCATION SCIENCE TO ENSURE THE HIGHEST QUALITY OF EDUCATION DELIVERY WITHIN EACH OF THE SCHOOLS WITHIN THE COLLEGE. THE COLLEGE HAS ALSO IMPLEMENTED AN ACADEMY OF EDUCATIONAL EXCELLENCE TO DEVELOP AND RECOGNIZE EDUCATORS TO BETTER PREPARE LEARNERS TO ADVANCE SCIENCE, MEET PATIENTS' NEEDS AND SERVE AS TRANSFORMATIVE LEADERS IN HEALTH CARE.AS PART OF ITS MEDICAL EDUCATION MISSION, MAYO CLINIC SPONSORS MAYO CLINIC PROCEEDINGS, A MONTHLY JOURNAL FOR PHYSICIANS AND OTHER MEDICAL PERSONNEL. THE JOURNAL IS PUBLISHED TO PROMOTE THE BEST INTERESTS OF PATIENTS BY ADVANCING THE KNOWLEDGE AND PROFESSIONALISM OF THE PHYSICIAN COMMUNITY. MAYO CLINIC PROCEEDINGS IS A PEER-REVIEWED CLINICAL JOURNAL IN GENERAL AND INTERNAL MEDICINE AND AMONG THE MOST WIDELY READ AND HIGHLY CITED SCIENTIFIC PUBLICATIONS FOR PHYSICIANS. MAYO CLINIC PROCEEDINGS HAS A CIRCULATION OF APPROXIMATELY 127,000 AND HAS BEEN CONTINUOUSLY PUBLISHED SINCE 1926. MAYO CLINIC PROCEEDINGS' CONTENT FOCUSES ON CLINICAL AND LABORATORY MEDICINE, HEALTH CARE POLICY AND ECONOMICS, MEDICAL EDUCATION AND ETHICS, AND RELATED TOPICS. ALL OF THESE EDUCATIONAL EFFORTS TO DISCOVER, DELIVER, EXPAND AND SHARE MEDICAL KNOWLEDGE PROMOTE MAYO'S CLINIC'S ABILITY TO PERPETUATE THE HIGHEST QUALITY AND SAFETY IN PATIENT CARE.

4d	Other program services (Describe in Schedule O.)
	(Expenses $ including grants of $ ) (Revenue $ )
4e	Total program service expenses4,690,062,570

Form 990 (2021)

Page 3

Part IV

Checklist of Required Schedules

Yes

Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule A Click to see attachment

.....................

Yes

Is the organization required to complete Schedule B, Schedule of Contributors? See instructions. Click to see attachment

...

Yes

Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part I Click to see attachment

.............

Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part II Click to see attachment

.........

Yes

Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Rev. Proc. 98-19? If "Yes," complete Schedule C, Part III Click to see attachment

Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part I Click to see attachment

.........................

Yes

Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part II Click to see attachment

....

Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes,"
complete Schedule D, Part III Click to see attachment

..............

Yes

Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IV Click to see attachment

..............

Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi endowments? If "Yes," complete Schedule D, Part V......

Yes

If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X, as applicable.

Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete
Schedule D, Part VI. Click to see attachment

...................

11a

Yes

Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VII Click to see attachment

.......

11b

Yes

Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIII Click to see attachment

.......

11c

Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IX Click to see attachment

............

11d

Yes

Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part X Click to see attachment

11e

Yes

Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part X Click to see attachment

11f

Yes

12a

Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XII Click to see attachment

......................

12a

Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment

12b

Yes

Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E Click to see attachment

Yes

14a

Did the organization maintain an office, employees, or agents outside of the United States? .....

14a

Yes

Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV......... Click to see attachment

14b

Yes

Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV..... Click to see attachment

Yes

Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV... Click to see attachment

Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I. See instructions. .... Click to see attachment

Yes

Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............ Click to see attachment

Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III................... Click to see attachment

20a

Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....

20a

If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?

20b

Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II..... Click to see attachment

Yes

Form 990 (2021)

Page 4

Part IV

Checklist of Required Schedules (continued)

Yes

Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........ Click to see attachment

Yes

Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5, about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment

Yes

24a

Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a............... Click to see list of attachments

24a

Yes

Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...

24b

Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............

24c

Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...

24d

25a

Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I .... Click to see attachment

25a

Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I....................... Click to see attachment

25b

Did the organization report any amount on Part X, line 5 or 22 for receivables from or payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II Click to see attachment

...........

Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or employee thereof, a grant selection committee member, or to a 35% controlled entity (including an employee thereof) or family member of any of these persons?

If "Yes," complete

Schedule L, Part III Click to see attachment

.........................

Yes

Was the organization a party to a business transaction with one of the following parties (see the Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):

A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If "Yes," complete Schedule L, Part IV...................... Click to see attachment

28a

A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV..... Click to see attachment

28b

Yes

A 35% controlled entity of one or more individuals and/or organizations described in line 28a or 28b? If "Yes," complete Schedule L, Part IV.....................

28c

Yes

Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M.. Click to see attachment

Yes

Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M ................. Click to see attachment

Yes

Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I

Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II........................

Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I............ Click to see attachment

Yes

Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1......................... Click to see attachment

Yes

35a

Did the organization have a controlled entity within the meaning of section 512(b)(13)?

35a

Yes

If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ... Click to see attachment

35b

Yes

Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2............. Click to see attachment

Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VI Click to see attachment

Did the organization complete Schedule O and provide explanations on Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............

Yes

Part V

Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........

Yes

Enter the number reported in box 3 of Form 1096. Enter -0- if not applicable ..

1,223

Enter the number of Forms W-2G included on line 1a. Enter -0- if not applicable .

Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................

Yes

Form 990 (2021)

Page 5

Part V

Statements Regarding Other IRS Filings and Tax Compliance (continued)

Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................

27,619

If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file. See instructions.

Yes

Did the organization have unrelated business gross income of $1,000 or more during the year?...

Yes

If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...

Yes

At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..

Yes

If "Yes," enter the name of the foreign country: MediumBullet

GM , CJ , EI , MX , UK
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).

Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..

Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?

If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............

Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...

If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................

Organizations that may receive deductible contributions under section 170(c).

Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................

If "Yes," did the organization notify the donor of the value of the goods or services provided? .....

Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................

If "Yes," indicate the number of Forms 8282 filed during the year ....

Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?

Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..

If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................

If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................

Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? ........

Sponsoring organizations maintaining donor advised funds.

Did the sponsoring organization make any taxable distributions under section 4966?........

Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...

Section 501(c)(7) organizations. Enter:

Initiation fees and capital contributions included on Part VIII, line 12 ...

10a

Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities

10b

Section 501(c)(12) organizations. Enter:

Gross income from members or shareholders .........

11a

Gross income from other sources. (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........

11b

12a

Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?

12a

If "Yes," enter the amount of tax-exempt interest received or accrued during the year.

12b

Section 501(c)(29) qualified nonprofit health insurance issuers.

Is the organization licensed to issue qualified health plans in more than one state? .........
Note. See the instructions for additional information the organization must report on Schedule O.

13a

Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....

13b

Enter the amount of reserves on hand ............

13c

14a

Did the organization receive any payments for indoor tanning services during the tax year?.....

14a

If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..

14b

Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or excess parachute payment(s) during the year? ....................
If "Yes," see the instructions and file Form 4720, Schedule N.

Yes

Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ..
If "Yes," complete Form 4720, Schedule O.

Section 501(c)(21) organizations. Did the trust, any disqualified person, or mine operator engage in any activities that would result in the imposition of an excise tax under section 4951, 4952, or 4953? ..
If "Yes," complete Form 6069.

Form 990 (2021)

Page 6

Part VI

Governance, Management, and Disclosure. For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.

Check if Schedule O contains a response or note to any line in this Part VI..............

Section A. Governing Body and Management

Yes

Enter the number of voting members of the governing body at the end of the tax year

If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.

Enter the number of voting members included in line 1a, above, who are independent

Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................

Yes

Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .

Yes

Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? .

Did the organization become aware during the year of a significant diversion of the organization’s assets? .

Did the organization have members or stockholders? ................

Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................

Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................

Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:

The governing body? .......................

Yes

Each committee with authority to act on behalf of the governing body? ............

Yes

Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......

Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)

Yes

10a

Did the organization have local chapters, branches, or affiliates? ............

10a

Yes

If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?

10b

Yes

11a

Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................

11a

Yes

Describe on Schedule O the process, if any, used by the organization to review this Form 990. .....

12a

Did the organization have a written conflict of interest policy? If "No," go to line 13.......

12a

Yes

Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................

12b

Yes

Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe on Schedule O how this was done...................

12c

Yes

Did the organization have a written whistleblower policy? ...............

Yes

Did the organization have a written document retention and destruction policy? .........

Yes

Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?

The organization’s CEO, Executive Director, or top management official ...........

15a

Other officers or key employees of the organization ................

15b

Yes

If "Yes" to line 15a or 15b, describe the process on Schedule O. See instructions.

16a

Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................

16a

Yes

If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............

16b

Yes

Section C. Disclosure

List the states with which a copy of this Form 990 is required to be filed MediumBullet

AL , AK , AR , CA , CT , FL , GA , IL , IN , KS , KY , MD , MA , MI , MN , MS , NH , NJ , NY , NC , NM , OK , OR , PA , RI , TN , UT , VA , WV , WI , SD , SC , AZ , DE , HI , ID , IA , LA , ME , WA , WY , VT , TX , NE , NV , MO , MT

Section 6104 requires an organization to make its Form 1023 (1024 or 1024-A, if applicable), 990, and 990-T (section 501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.

Own website Another's website Upon request Other (explain in Schedule O)

Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.

State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBullet

CORPORATE TAX200 FIRST STREET SW ROCHESTER,MN55905 (507) 538-1297

Form 990 (2021)

Page 7

Part VII

Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors

Check if Schedule O contains a response or note to any line in this Part VII..............

Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees

1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet

List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

List all of the organization’s current key employees, if any. See the instructions for definition of "key employee."

List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (box 5 of Form W-2, Form 1099-MISC, and/or box 1 of Form 1099-NEC) of more than $100,000 from the
organization and any related organizations.

List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

See the instructions for the order in which to list the persons above.

Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)					(D) Reportable compensation from the organization (W-2/1099-MISC/1099-NEC)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)	(F) Estimated amount of other compensation from the organization and related organizations
(A) Name and title
(1) FARRUGIA MD GIANRICO...................................................................... TRUSTEE/PRESIDENT/CEO	1.00 ................. 40.00	X	X				0	3,388,660	96,514
(2) BOLTON JEFFREY W...................................................................... TRUSTEE/VP	1.00 ................. 40.00	X	X				0	2,077,195	34,523
(3) THIELEN MD KENT R...................................................................... TRUSTEE/VP	1.00 ................. 40.00	X	X				0	1,697,812	93,686
(4) GRAY MD RICHARD J...................................................................... TRUSTEE/VP	1.00 ................. 40.00	X	X				0	1,694,419	86,298
(5) KRAUSS MD WILLIAM E...................................................................... PHYSICIAN	40.00 ................. 0.00				X		1,423,636	0	89,486
(6) DAHLEN DENNIS E...................................................................... CFO	1.00 ................. 40.00		X				0	1,378,621	92,038
(7) LANZINO MD GIUSEPPE...................................................................... PHYSICIAN	40.00 ................. 0.00				X		1,352,629	0	86,036
(8) PICHELMANN MD MARK A...................................................................... CHAIR-NWWI NEUROSURGERY	40.00 ................. 0.00				X		1,357,302	0	74,826
(9) MURPHY JOSHUA B...................................................................... SECY	1.00 ................. 40.00		X				0	1,314,095	96,634
(10) HARPER JR MD CHARLES M...................................................................... TRUSTEE	40.00 ................. 0.00	X					1,356,080	0	38,339
(11) MEYER MD FREDRIC B...................................................................... FORMER KEY EMPLOYEE	0.00 ................. 40.00					X	0	1,341,683	48,992
(12) CLARKE MD MICHELLE J...................................................................... PHYSICIAN	40.00 ................. 0.00				X		1,292,887	0	76,456
(13) MARSH MD W RICHARD...................................................................... DIR-SPINE CENTER	40.00 ................. 0.00				X		1,329,674	0	38,378
(14) GORMAN PAUL A...................................................................... TREASURER/ASST TREASURER	1.00 ................. 40.00		X				0	1,188,403	90,128
(15) GORES MD GREGORY J...................................................................... EXECUTIVE DEAN OF RESEARCH	40.00 ................. 0.00			X			1,243,899	0	29,298
(16) OTLEY MD CLARK C...................................................................... PHYSICIAN	40.00 ................. 0.00			X			1,051,074	0	93,056
(17) AMMASH MD NASER M...................................................................... FORMER KEY EMPLOYEE	0.00 ................. 40.00					X	0	1,063,579	78,459

Form 990 (2021)

Page 8

Part VII

Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)				(D) Reportable compensation from the organization (W-2/1099-MISC/1099-NEC)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)	(F) Estimated amount of other compensation from the organization and related organizations
(A) Name and title
(18) WILLIAMSON MARY J........................................................................ VICE CHAIR/CAO-MCHS	40.00 .......................0.00			X		1,037,578	0	79,382
(19) WILLIAMS MD AMY W........................................................................ TRUSTEE	1.00 .......................40.00	X				0	1,030,707	82,319
(20) ZORN CHRISTINA K........................................................................ TRUSTEE/VP/ASST SECY	1.00 .......................40.00	X	X			0	998,035	81,965
(21) MENKOSKY PAULA E........................................................................ ASST SECY	1.00 .......................40.00		X			0	940,276	85,953
(22) CALLSTROM MD MATTHEW R........................................................................ CHAIR-DEPT OF RADIOLOGY	40.00 .......................0.00			X		903,129	0	87,892
(23) SHAH MD VIJAY........................................................................ CHAIR-ROCH INTERN MED	40.00 .......................0.00			X		900,838	0	88,139
(24) HEBL MD JAMES R........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	879,599	0	76,270
(25) RIHAL MD CHARANJIT S........................................................................ TRUSTEE	40.00 .......................0.00	X				847,888	0	95,939
(26) KHAN RITA G........................................................................ FORMER KEY EMPLOYEE	0.00 .......................40.00				X	0	838,469	55,132
(27) FONSECA MD RAFAEL........................................................................ TRUSTEE	1.00 .......................40.00	X				0	798,446	82,618
(28) WALD MD JOHN T........................................................................ PHYSICIAN	40.00 .......................0.00			X		760,380	0	99,539
(29) CAMILLERI MD MICHAEL........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	821,114	0	28,307
(30) MORICE MD WILLIAM G........................................................................ CHAIR-LAB MED & PATH	40.00 .......................0.00			X		751,613	0	90,945
(31) LUETMER MD PATRICK H........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	774,849	0	62,512
(32) KENDRICK MD MICHAEL L........................................................................ CHIAR-SURGERY	40.00 .......................0.00			X		738,477	0	81,300
(33) LEIBOVICH MD BRADLEY C........................................................................ PHYSICIAN	40.00 .......................0.00			X		700,131	0	86,597
(34) LOFTUS MD CONOR G........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	701,690	0	80,980
(35) HOFFMAN III HARRY N........................................................................ FORMER OFFICER	0.00 .......................40.00				X	0	751,736	20,638
(36) DOWDY MD SEAN C........................................................................ CHIEF VALUE OFFICER	40.00 .......................0.00			X		669,062	0	84,789
(37) GERTZ MD MORIE A........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	682,051	0	36,805
(38) CIMA MD ROBERT R........................................................................ PHYSICIAN	40.00 .......................0.00			X		629,337	0	80,655
(39) BERRY MD DANIEL J........................................................................ TRUSTEE	40.00 .......................0.00	X				646,271	0	55,136
(40) FRANK MD IGOR........................................................................ PHYSICIAN	40.00 .......................0.00			X		616,095	0	80,613
(41) GALANIS MD EVANTHIA........................................................................ EXECUTIVE DEAN OF DEVELOPMENT	40.00 .......................0.00			X		599,209	0	79,257
(42) OKUNO MD SCOTT H........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	586,750	0	90,432
(43) BROWN MD MICHAEL J........................................................................ PHYSICIAN	40.00 .......................0.00			X		587,314	0	85,239
(44) KHAN MD AMIR R........................................................................ PHYSICIAN	40.00 .......................0.00			X		585,154	0	86,446
(45) MCLAUGHLIN MD SARAH A........................................................................ TRUSTEE	1.00 .......................40.00	X				0	623,662	47,684
(46) DIDEHBAN ROSHANAK........................................................................ TRUSTEE	40.00 .......................0.00	X				616,979	0	48,584
(47) DIASIO MD ROBERT B........................................................................ PHYSICIAN	40.00 .......................0.00			X		631,920	0	27,805
(48) PETERS MD STEVE G........................................................................ PHYSICIAN	40.00 .......................0.00			X		591,697	0	38,597
(49) FRANCIS JAMES R........................................................................ ASST TREASURER	1.00 .......................40.00		X			0	526,219	99,268
(50) GAZELKA MD HALENA M........................................................................ PHYSICIAN	40.00 .......................0.00			X		537,523	0	77,299
(51) WHITED MD BRIAN L........................................................................ FORMER KEY EMPLOYEE	1.00 .......................40.00				X	168,396	360,298	83,718
(52) HORLOCKER MD TERESE T........................................................................ PHYSICIAN	40.00 .......................0.00			X		576,298	0	24,979
(53) LUCCHINETTI MD CLAUDIA F........................................................................ TRUSTEE	40.00 .......................0.00	X				495,095	0	93,724
(54) HAYES MD SHARONNE N........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	502,366	0	85,805
(55) KRAHN MD LOIS E........................................................................ TRUSTEE	1.00 .......................40.00	X				0	478,121	95,711
(56) NARR MD BRADLY J........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	508,202	0	27,439
(57) DIETER HEIDI L........................................................................ CHIEF RESEARCH OFFICER	40.00 .......................0.00			X		449,771	0	59,666
(58) WARNER MD MARK A........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	448,814	0	36,169
(59) HAEFLINGER RICKY J........................................................................ ASST TREASURER	40.00 .......................0.00		X			439,935	0	4,798
(60) HUBERT SHERRY L........................................................................ ASST SECY	1.00 .......................40.00		X			0	351,509	87,505
(61) GOSTOUT MD BOBBIE S........................................................................ TRUSTEE/VP	1.00 .......................40.00	X	X			0	434,775	3,466
(62) GREENE MD EDDIE L........................................................................ TRUSTEE	40.00 .......................0.00	X				342,290	0	89,571
(63) NORBY SUSAN M........................................................................ FORMER OFFICER	0.00 .......................40.00				X	0	348,140	77,265
(64) HADAWAY CHERYL J........................................................................ FORMER KEY EMPLOYEE	40.00 .......................0.00				X	391,885	0	22,102
(65) LOCKETT KEVIN M........................................................................ FORMER OFFICER	0.00 .......................40.00				X	0	270,924	69,718
(66) BROWN WILLIAM A........................................................................ ASST TREASURER	1.00 .......................40.00		X			0	256,862	26,916
(67) NORBY MARK L........................................................................ ASST TREASURER	1.00 .......................40.00		X			0	99,451	43,431
(68) BAKER JR DOUGLAS M........................................................................ TRUSTEE	5.00 .......................0.00	X				0	3,121	0
(69) POWELL MICHAEL K........................................................................ TRUSTEE/CHAIR	5.00 .......................0.00	X	X			0	3,002	0
(70) ROBERTS ROBIN R........................................................................ TRUSTEE	5.00 .......................0.00	X				0	1,239	0
(71) BAICKER KATHERINE........................................................................ TRUSTEE	5.00 .......................0.00	X				0	1,063	0
(72) ALIX JAY........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(73) BILICIC GEORGE W........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(74) BURNS URSULA M........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(75) DAVIS RICHARD K........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(76) DI PIAZZA JR SAMUEL A........................................................................ TRUSTEE/CHAIR	5.00 .......................0.00	X	X			0	0	0
(77) HALVORSON GEORGE C........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(78) MULALLY ALAN R........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(79) PERETSMAN NANCY B........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(80) SALAZAR KENNETH L........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(81) SCHMIDT ERIC E........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(82) STEER MD RANDOLPH C........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(83) SWEENEY ANNE M........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0
(84) TOMM CHARLES B........................................................................ TRUSTEE	5.00 .......................0.00	X				0	0	0

1b	Sub-Total................
c	Total from continuation sheets to Part VII, Section A....
d	Total (add lines 1b and 1c)...........	32,526,881	24,260,522	4,560,166

Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet

6,019

Yes

Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............

Yes

For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual...........................

Yes

Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........

Section B. Independent Contractors

Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.

(A) Name and business address	(B) Description of services	(C) Compensation
MAYO FOUNDATION FOR MEDICAL EDUCATION & 200 FIRST STREET SW ROCHESTER,MN55905	PROCUREMENT & MED SUPPORT SERVICES	528,674,221
MAYO CLINIC JACKSONVILLE 4500 SAN PABLO ROAD JACKSONVILLE,FL32224	MEDICAL SUPPORT SERVICES	4,163,894
MCHS - SOUTHWEST MINNESOTA REGION 1025 MARSH STREET MANKATO,MN56001	MEDICAL SUPPORT SERVICES	399,784
MCHS - NORTHWEST WISCONSIN REGION INC 1221 WHIPPLE STREET EAU CLAIRE,WI54703	MEDICAL SUPPORT SERVICES	367,519
MAYO CLINIC ARIZONA 13400 EAST SHEA BLVD SCOTTSDALE,AZ85259	MEDICAL SUPPORT SERVICES	256,862
2 Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization 6

Form 990 (2021)

Page 9

Part VIII

Statement of Revenue

Check if Schedule O contains a response or note to any line in this Part VIII.............

(A)
Total revenue

(B)
Related or
exempt
function
revenue

(D)
Revenue
excluded from
tax under sections
512 - 514

1a	Federated campaigns..		1a	51,172
b	Membership dues..		1b
c	Fundraising events..		1c
d	Related organizations		1d	1,556,817,953
e	Government grants (contributions)		1e	340,691,384

f	All other contributions, gifts, grants, and similar amounts not included above		1f	927,765,757

g	Noncash contributions included in lines 1a - 1f:$		1g	117,255,400

h Total. Add lines 1a-1f.......		2,825,326,266

		Business Code
2a	NET PATIENT CARE	621110	4,054,186,620	3,126,634,928	927,551,692
b	EDUCATION	611600	26,082,394	26,082,394
c	RESEARCH	541700	9,035,989	7,000,006	2,035,983
d
e
f	All other program service revenue.
g	Total. Add lines 2a–2f .....		4,089,305,003

3 Investment income (including dividends, interest, and othersimilar amounts) ......			285,844,475		15,702,238	270,142,237
4 Income from investment of tax-exempt bond proceeds			135			135
5 Royalties...........			21,849,386	21,849,386
		(ii) Personal	(i) Real
6a	Gross rents		1,037,522	6a
b	Less: rental expenses		141,785	6b
c	Rental income or (loss)		895,737	6c
d	Net rental income or (loss).......			895,737			895,737
		(ii) Other	(i) Securities
7a	Gross amount from sales of assets other than inventory	10,203,926	6,395,286,766	7a
b	Less: cost or other basis and sales expenses	7,539,918	5,661,911,654	7b
c	Gain or (loss)	2,664,008	733,375,112	7c
d	Net gain or (loss).........			736,039,120			736,039,120
8a	Gross income from fundraising events (not including $ of contributions reported on line 1c). See Part IV, line 18 ....
			8a
b	Less: direct expenses ...		8b
c	Net income or (loss) from fundraising events..
9a	Gross income from gaming activities. See Part IV, line 19 ...
			9a
b	Less: direct expenses ...		9b
c	Net income or (loss) from gaming activities..
10a	Gross sales of inventory, less returns and allowances ..
			10a	243,196
b	Less: cost of goods sold ..		10b	178,191
c	Net income or (loss) from sales of inventory..			65,005		65,005
Business Code			Miscellaneous Revenue
11a	MISC. CONSULTING		541610	14,762,826	3,452,714	4,936,543	6,373,569
b	MISC. REVENUE		900099	9,290,096	7,290,423		1,999,673
c	CAFETERIA/VENDING		722514	4,709,278	4,709,278
d	All other revenue ....			5,153,677	717,547		4,436,130
e	Total. Add lines 11a–11d ......			33,915,877
12	Total revenue. See instructions.....			7,993,241,004	3,197,736,676	950,291,461	1,019,886,601

Form 990 (2021)

Page 10

Part IX

Statement of Functional Expenses

Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX..............

Do not include amounts reported on lines 6b, 7b, 8b, 9b, and 10b of Part VIII.		(A) Total expenses	(B) Program service expenses	(C) Management and general expenses	(D) Fundraising expenses

1	Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 ....	512,881,152	512,881,152
2	Grants and other assistance to domestic individuals. See Part IV, line 22 ...........	25,526,647	25,526,647
3	Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. .............	2,152,006	2,152,006
4	Benefits paid to or for members .......
5	Compensation of current officers, directors, trustees, and key employees ...........	21,192,620	19,154,570	1,744,681	293,369
6	Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........	14,337,044	12,911,514	1,076,630	348,900
7	Other salaries and wages........	2,188,611,556	2,076,761,708	86,315,745	25,534,103
8	Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) ....	13,962,637	617,210	10,697,450	2,647,977
9	Other employee benefits .......	451,845,518	431,541,206	17,146,001	3,158,311
10	Payroll taxes ...........	152,247,406	144,394,764	6,287,349	1,565,293
11	Fees for services (non-employees):
a	Management ......
b	Legal .........	1,305,011	716,279	131,618	457,114
c	Accounting ...........	177,882	1	177,881
d	Lobbying ...........	192,699	192,699
e	Professional fundraising services. See Part IV, line 17	617,878			617,878
f	Investment management fees ......	3,746,619	37,500	3,709,119
g	Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O)	1,080,646,813	269,988,616	802,618,590	8,039,607
12	Advertising and promotion ....	16,831,636	16,761,070	11,651	58,915
13	Office expenses .......	222,968,019	207,547,674	14,743,599	676,746
14	Information technology ......	49,721,965	48,986,795	568,760	166,410
15	Royalties ..	3,928,499	3,928,499
16	Occupancy ...........	83,264,646	36,823,120	45,078,663	1,362,863
17	Travel ............	20,310,641	19,661,786	340,893	307,962
18	Payments of travel or entertainment expenses for any federal, state, or local public officials .
19	Conferences, conventions, and meetings ....	1,694,434	1,670,572	16,495	7,367
20	Interest ...........	116,586,630	76,317,365	40,269,265
21	Payments to affiliates .......
22	Depreciation, depletion, and amortization ..	188,910,481	186,790,030	2,050,023	70,428
23	Insurance ...	16,995,933	16,995,933
24	Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a	MEDICAL SUPPLIES	452,207,673	452,207,673
b	UBIT	21,093,570	21,063,708	29,862
c	MN CARE TAX	41,853,858	41,853,858
d	EMPLOYEE RELATED	30,235,991	27,597,472	2,367,814	270,705
e	All other expenses	37,071,925	34,981,143	2,070,383	20,399
25	Total functional expenses. Add lines 1 through 24e	5,773,119,389	4,690,062,570	1,037,452,472	45,604,347
26	Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here if following SOP 98-2 (ASC 958-720).

Form 990 (2021)

Page 11

Part X

Balance Sheet

Check if Schedule O contains a response or note to any line in this Part IX..............

				(A) Beginning of year		(B) End of year

1	Cash–non-interest-bearing ........			1,875,254	1	1,715,225
2	Savings and temporary cash investments .........			3,043,150	2	88,122
3	Pledges and grants receivable, net ......			483,543,530	3	496,652,443
4	Accounts receivable, net .............			529,412,102	4	550,987,625
5	Loans and other receivables from any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
					5
6	Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
					6
7	Notes and loans receivable, net ...........			2,407,889	7	2,101,222
8	Inventories for sale or use ............			6,912,594	8	9,188,537
9	Prepaid expenses and deferred charges ......			15,054,253	9	40,641,706
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	3,804,949,967
b	Less: accumulated depreciation	10b	2,337,858,096	1,446,595,885	10c	1,467,091,871
11	Investments—publicly traded securities .			482,550,370	11	577,599,401
12	Investments—other securities. See Part IV, line 11 .....			11,795,440,598	12	14,825,293,684
13	Investments—program-related. See Part IV, line 11 ..				13
14	Intangible assets ...............				14
15	Other assets. See Part IV, line 11 ...........			1,761,383,256	15	2,572,442,526
16	Total assets. Add lines 1 through 15 (must equal line 33)...			16,528,218,881	16	20,543,802,362

17	Accounts payable and accrued expenses .....	4,016,023,524	17	2,627,802,035
18	Grants payable ...		18
19	Deferred revenue .........	120,424,474	19	111,583,445
20	Tax-exempt bond liabilities .........	1,546,708,763	20	1,406,307,809
21	Escrow or custodial account liability. Complete Part IV of Schedule D		21
22	Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
			22
23	Secured mortgages and notes payable to unrelated third parties ..	1,992,192,259	23	2,493,906,542
24	Unsecured notes and loans payable to unrelated third parties ..		24
25	Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D	3,316,332,263	25	3,526,450,006
26	Total liabilities. Add lines 17 through 25..	10,991,681,283	26	10,166,049,837

	Organizations that follow FASB ASC 958, check here and complete lines 27, 28, 32, and 33.
27	Net assets without donor restrictions ..........	1,977,337,635	27	5,989,293,754
28	Net assets with donor restrictions ...........	3,559,199,963	28	4,388,458,771
	Organizations that do not follow FASB ASC 958, check here and complete lines 29 through 33.
29	Capital stock or trust principal, or current funds .....		29
30	Paid-in or capital surplus, or land, building or equipment fund ...		30
31	Retained earnings, endowment, accumulated income, or other funds		31
32	Total net assets or fund balances ...........	5,536,537,598	32	10,377,752,525
33	Total liabilities and net assets/fund balances ........	16,528,218,881	33	20,543,802,362

Form 990 (2021)

Page 12

Part XI

Reconcilliation of Net Assets

Check if Schedule O contains a response or note to any line in this Part XI..............

Total revenue (must equal Part VIII, column (A), line 12) ............

7,993,241,004

Total expenses (must equal Part IX, column (A), line 25) ............

5,773,119,389

Revenue less expenses. Subtract line 2 from line 1 ..............

2,220,121,615

Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ..

5,536,537,598

Net unrealized gains (losses) on investments ...............

1,178,220,649

Donated services and use of facilities .................

Investment expenses .....................

Prior period adjustments .....................

Other changes in net assets or fund balances (explain in Schedule O) ........

1,442,872,663

Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32, column (B))

10,377,752,525

Part XII

Financial Statements and Reporting

Check if Schedule O contains a response or note to any line in this Part XII.............

Yes

Accounting method used to prepare the Form 990: Cash Accrual Other
If the organization changed its method of accounting from a prior year or checked "Other," explain on
Schedule O.

Were the organization’s financial statements compiled or reviewed by an independent accountant?

If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:

Separate basis Consolidated basis Both consolidated and separate basis

Were the organization’s financial statements audited by an independent accountant?

Yes

If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:

Separate basis Consolidated basis Both consolidated and separate basis

If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?

Yes

If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.

As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?

Yes

If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.

Yes

Form 990 (2021)

Additional Data

Software ID:
Software Version:

Form 990, Special Condition Description:

Special Condition Description

- TIN:

SCHEDULE A
(Form 990)

Department of the Treasury
Internal Revenue Service

Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow

Attach to Form 990 or Form 990-EZ.
right arrow

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Reason for Public Charity Status (All organizations must complete this part.) See instructions.

The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)

A church, convention of churches, or association of churches described in section 170(b)(1)(A)(i).

A school described in section 170(b)(1)(A)(ii). (Attach Schedule E (Form 990).)

A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name, city, and state:

An organization operated for the benefit of a college or university owned or operated by a governmental unit described in section 170(b)(1)(A)(iv). (Complete Part II.)

A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in section 170(b)(1)(A)(vi). (Complete Part II.)

A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)

An agricultural research organization described in 170(b)(1)(A)(ix) operated in conjunction with a land-grant college or university or a non-land grant college of agriculture. See instructions. Enter the name, city, and state of the college or university:

An organization that normally receives: (1) more than 33 1/3% of its support from contributions, membership fees, and gross receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 33 1/3% of its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)

An organization organized and operated exclusively to test for public safety. See section 509(a)(4).

An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box on lines 12a through 12d that describes the type of supporting organization and complete lines 12e, 12f, and 12g.

Type I. A supporting organization operated, supervised, or controlled by its supported organization(s), typically by giving the supported organization(s) the power to regularly appoint or elect a majority of the directors or trustees of the supporting organization. You must complete Part IV, Sections A and B.

Type II. A supporting organization supervised or controlled in connection with its supported organization(s), by having control or management of the supporting organization vested in the same persons that control or manage the supported organization(s). You must complete Part IV, Sections A and C.

Type III functionally integrated. A supporting organization operated in connection with, and functionally integrated with, its supported organization(s) (see instructions). You must complete Part IV, Sections A, D, and E.

Type III non-functionally integrated. A supporting organization operated in connection with its supported organization(s) that is not functionally integrated. The organization generally must satisfy a distribution requirement and an attentiveness requirement (see instructions). You must complete Part IV, Sections A and D, and Part V.

Check this box if the organization received a written determination from the IRS that it is a Type I, Type II, Type III functionally integrated, or Type III non-functionally integrated supporting organization.

Enter the number of supported organizations ...............................

Provide the following information about the supported organization(s).

(i) Name of supported organization	(ii) EIN	(iv) Is the organization listed in your governing document?		(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)
(i) Name of supported organization	(ii) EIN	Yes	No	(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)


Total

For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.

Cat. No. 11285F

Schedule A (Form 990) 2021

Page 2

Part II

Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") ..
2	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....
3	The value of services or facilities furnished by a governmental unit to the organization without charge..
4	Total. Add lines 1 through 3
5	The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) ..
6	Public support. Subtract line 5 from line 4.

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
7	Amounts from line 4..
8	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...
9	Net income from unrelated business activities, whether or not the business is regularly carried on..
10	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..
11	Total support. Add lines 7 through 10

Gross receipts from related activities, etc. (see instructions) ..................

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here ........................................ right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 6, column (f) divided by line 11, column (f)) .........

Public support percentage for 2020 Schedule A, Part II, line 14 ...............

16a

33 1/3% support test—2021. If the organization did not check the box on line 13, and line 14 is 33 1/3 % or more, check this box
and stop here. The organization qualifies as a publicly supported organization ....................... right arrow

33 1/3% support test—2020. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow

17a

10%-facts-and-circumstances test—2021. If the organization did not check a box on line 13, 16a, or 16b, and line 14
is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain
in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported
organization ..................................................... right arrow

10%-facts-and-circumstances test—2020. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line
15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here.
Explain in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly
supported organization ................................................ right arrow

Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow

Schedule A (Form 990) 2021

Page 3

Part III

Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .	1,722,852,961	1,975,507,156	2,194,234,892	2,422,520,612	2,825,326,266	11,140,441,887
2	Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose	3,359,185,346	3,390,245,417	3,324,127,662	3,408,043,003	3,197,736,676	16,679,338,104
3	Gross receipts from activities that are not an unrelated trade or business under section 513 .....	4,697,015	17,480,366	17,097,585	9,994,115	12,809,372	62,078,453
4	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5	The value of services or facilities furnished by a governmental unit to the organization without charge
6	Total. Add lines 1 through 5	5,086,735,322	5,383,232,939	5,535,460,139	5,840,557,730	6,035,872,314	27,881,858,444
7a	Amounts included on lines 1, 2, and 3 received from disqualified persons						0
b	Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.						0
c	Add lines 7a and 7b..						0
8	Public support. (Subtract line 7c from line 6.)						27,881,858,444

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
9	Amounts from line 6...	5,086,735,322	5,383,232,939	5,535,460,139	5,840,557,730	6,035,872,314	27,881,858,444
10a	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..	104,141,866	54,704,231	230,253,855	200,743,329	271,179,894	861,023,175
b	Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.	63,998,037	78,762,106	114,491,776	180,609,096	160,531,494	598,392,509
c	Add lines 10a and 10b.	168,139,903	133,466,337	344,745,631	381,352,425	431,711,388	1,459,415,684
11	Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on.
12	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..	10,722,804	5,805,837				16,528,641
13	Total support. (Add lines 9, 10c, 11, and 12.)..	5,265,598,029	5,522,505,113	5,880,205,770	6,221,910,155	6,467,583,702	29,357,802,769

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,
check this box and stop here............................................. right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 8, column (f) divided by line 13, column (f)) .........

94.970 %

Public support percentage from 2020 Schedule A, Part III, line 15 ...............

95.720 %

Section D. Computation of Investment Income Percentage

Investment income percentage for 2021 (line 10c, column (f) divided by line 13, column (f)) ......

4.970 %

Investment income percentage from 2020 Schedule A, Part III, line 17 .............

4.190 %

19a

331/3% support tests—2021. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ....... right arrow

33 1/3% support tests—2020. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization .... right arrow

Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions .... right arrow

Schedule A (Form 990) 2021

Page 4

Part IV

Supporting Organizations

(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, of Part I, complete Sections A and B. If you checked box 12b, of Part I, complete Sections A and C. If you checked box 12c, of Part I, complete Sections A, D, and E. If you checked box12d, of Part I, complete Sections A and D, and complete Part V.)

Section A. All Supporting Organizations

Yes

Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.

Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).

Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer lines 3b and 3c below.

Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.

Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.

Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below.

Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.

Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.

Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).

Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?

Substitutions only. Was the substitution the result of an event beyond the organization's control?

Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.

Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990) .

Did the organization make a loan to a disqualified person (as defined in section 4958) not described on line 7? If “Yes,” complete Part I of Schedule L (Form 990).

Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons, as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.

Did one or more disqualified persons (as defined on line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.

Did a disqualified person (as defined on line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.

10a

Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.

10a

Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).

10b

Schedule A (Form 990) 2021

Page 5

Part IV

Supporting Organizations (continued)

Yes

Has the organization accepted a gift or contribution from any of the following persons?

A person who directly or indirectly controls, either alone or together with persons described on lines 11b and 11c below, the governing body of a supported organization?

11a

A family member of a person described on 11a above?

11b

A 35% controlled entity of a person described on line 11a or 11b above? If “Yes” to 11a, 11b, or 11c, provide detail in Part VI.

11c

Section B. Type I Supporting Organizations

Yes

Did the officers, directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.

Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.

Section C. Type II Supporting Organizations

Yes

Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).

Section D. All Type III Supporting Organizations

Yes

Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?

Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).

By reason of the relationship described in line 2 above, did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.

Section E. Type III Functionally-Integrated Supporting Organizations

Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):

The organization satisfied the Activities Test. Complete line 2 below.

The organization is the parent of each of its supported organizations. Complete line 3 below.

The organization supported a governmental entity. Describe in Part VI how you supported a government entity (see instructions)

Activities Test. Answer lines 2a and 2b below.

Yes

Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.

Did the activities described on line 2a, above constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.

Parent of Supported Organizations. Answer lines 3a and 3b below.

Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations?If "Yes" or "No", provide details in Part VI.

Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.

Schedule A (Form 990) 2021

Page 6

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations

Check here if the organization satisfied the Integral Part Test as a qualifying trust on Nov. 20, 1970 (explain in Part VI). See instructions. All other Type III non-functionally integrated supporting organizations must complete Sections A through E.

	Section A - Adjusted Net Income		(A) Prior Year	(B) Current Year (optional)
1	Net short-term capital gain	1
2	Recoveries of prior-year distributions	2
3	Other gross income (see instructions)	3
4	Add lines 1 through 3	4
5	Depreciation and depletion	5
6	Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions)	6
7	Other expenses (see instructions)	7
8	Adjusted Net Income (subtract lines 5, 6 and 7 from line 4)	8

	Section B - Minimum Asset Amount		(A) Prior Year	(B) Current Year (optional)
1	Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year):	1
a	Average monthly value of securities	1a
b	Average monthly cash balances	1b
c	Fair market value of other non-exempt-use assets	1c
d	Total (add lines 1a, 1b, and 1c)	1d
e	Discount claimed for blockage or other factors (explain in detail in Part VI):
2	Acquisition indebtedness applicable to non-exempt use assets	2
3	Subtract line 2 from line 1d	3
4	Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions).	4
5	Net value of non-exempt-use assets (subtract line 4 from line 3)	5
6	Multiply line 5 by 0.035	6
7	Recoveries of prior-year distributions	7
8	Minimum Asset Amount (add line 7 to line 6)	8

	Section C - Distributable Amount		Current Year
1	Adjusted net income for prior year (from Section A, line 8, Column A)	1
2	Enter 85% of line 1	2
3	Minimum asset amount for prior year (from Section B, line 8, Column A)	3
4	Enter greater of line 2 or line 3	4
5	Income tax imposed in prior year	5
6	Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions)	6

Check here if the current year is the organization's first as a non-functionally-integrated Type III supporting organization (see instructions)

Schedule A (Form 990) 2021

Page 7

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)

Section D - Distributions		Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes	1
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity	2
3 Administrative expenses paid to accomplish exempt purposes of supported organizations	3
4 Amounts paid to acquire exempt-use assets	4
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI)	5
6 Other distributions (describe in Part VI). See instructions	6
7Total annual distributions. Add lines 1 through 6.	7
8 Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions	8
9 Distributable amount for 2021 from Section C, line 6	9
10 Line 8 amount divided by Line 9 amount	10

Section E - Distribution Allocations (see instructions)		(i) Excess Distributions	(ii) Underdistributions Pre-2021	(iii) Distributable Amount for 2021
1 Distributable amount for 2021 from Section C, line 6
2 Underdistributions, if any, for years prior to 2021 (reasonable cause required-- explain in Part VI). See instructions.
3 Excess distributions carryover, if any, to 2021:
a From 2016.......
b From 2017.......
c From 2018.......
d From 2019.......
e From 2020.......
fTotal of lines 3a through e
g Applied to underdistributions of prior years
h Applied to 2021 distributable amount
i Carryover from 2016 not applied (see instructions)
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.
4Distributions for 2021 from Section D, line 7:
$
a Applied to underdistributions of prior years
b Applied to 2021 distributable amount
c Remainder. Subtract lines 4a and 4b from line 4.
5 Remaining underdistributions for years prior to 2021, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions.
6 Remaining underdistributions for 2021. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions.
7 Excess distributions carryover to 2022. Add lines 3j and 4c.
8 Breakdown of line 7:
a Excess from 2017.....
b Excess from 2018.....
c Excess from 2019.....
d Excess from 2020.....
e Excess from 2021.....

Schedule A (Form 990) (2021)

Schedule A (Form 990) 2021

Page 8

Part VI

Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Return Reference	Explanation
SCHEDULE A, PART III, LINE 12, EXPLANATION OF OTHER INCOME:	MISCELLANEOUS - 2017 AMOUNT: $ 10,722,804. 2018 AMOUNT: $ 5,805,837.
SCHEDULE A PART I LINE 2:	WHILE THE IRS DETERMINED THAT MAYO CLINIC QUALIFIES UNDER LINE 10, AN ORGANIZATION THAT NORMALLY RECEIVES: (1) MORE THAN 33 1/3% OF ITS SUPPORT FROM CONTRIBUTIONS, MEMBERSHIP FEES, AND GROSS RECEIPTS FROM ACTIVITIES RELATED TO ITS EXEMPT FUNCTIONS, AND (2) NO MORE THAN 33 1/3% OF ITS SUPPORT FROM GROSS INVESTMENT INCOME AND UNRELATED BUSINESS TAXABLE INCOME, WE BELIEVE THAT IT ALSO QUALIFIES UNDER THE CLASSIFICATION OF LINE 2 - A SCHOOL DESCRIBED IN SECTION 170(B)(1)(A)(II), LINE 3 - A HOSPITAL OR A COOPERATIVE HOSPITAL SERVICE ORGANIZATION DESCRIBED IN SECTION 170(B)(1)(A)(III), AND LINE 7, AN ORGANIZATION THAT NORMALLY RECEIVES A SUBSTANTIAL PART OF ITS SUPPORT FROM A GOVERNMENTAL UNIT OR FROM THE GENERAL PUBLIC DESCRIBED IN SECTION 170(B)(1)(A)(VI).

Return Reference

Explanation

SCHEDULE A, PART III, LINE 12, EXPLANATION OF OTHER INCOME:

MISCELLANEOUS - 2017 AMOUNT: $ 10,722,804. 2018 AMOUNT: $ 5,805,837.

SCHEDULE A PART I LINE 2:

WHILE THE IRS DETERMINED THAT MAYO CLINIC QUALIFIES UNDER LINE 10, AN ORGANIZATION THAT NORMALLY RECEIVES: (1) MORE THAN 33 1/3% OF ITS SUPPORT FROM CONTRIBUTIONS, MEMBERSHIP FEES, AND GROSS RECEIPTS FROM ACTIVITIES RELATED TO ITS EXEMPT FUNCTIONS, AND (2) NO MORE THAN 33 1/3% OF ITS SUPPORT FROM GROSS INVESTMENT INCOME AND UNRELATED BUSINESS TAXABLE INCOME, WE BELIEVE THAT IT ALSO QUALIFIES UNDER THE CLASSIFICATION OF LINE 2 - A SCHOOL DESCRIBED IN SECTION 170(B)(1)(A)(II), LINE 3 - A HOSPITAL OR A COOPERATIVE HOSPITAL SERVICE ORGANIZATION DESCRIBED IN SECTION 170(B)(1)(A)(III), AND LINE 7, AN ORGANIZATION THAT NORMALLY RECEIVES A SUBSTANTIAL PART OF ITS SUPPORT FROM A GOVERNMENTAL UNIT OR FROM THE GENERAL PUBLIC DESCRIBED IN SECTION 170(B)(1)(A)(VI).

Schedule A (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule B
(Form 990)

Department of the Treasury
Internal Revenue Service

Schedule of Contributors

Attach to Form 990, 990-EZ, or 990-PF.

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Organization type (check one):

Filers of:

Section:

Form 990 or 990-EZ

501(c)( ) (enter number) organization

4947(a)(1) nonexempt charitable trust not treated as a private foundation

527 political organization

Form 990-PF

501(c)(3) exempt private foundation

4947(a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule.
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.

General Rule

For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, contributions totaling $5,000 or more (in money or other property) from any one contributor. Complete Parts I and II. See instructions for determining a contributor's total contributions.

Special Rules

For an organization described in section 501(c)(3) filing Form 990 or 990-EZ that met the 33¹/3% support test of the regulations
under sections 509(a)(1) and 170(b)(1)(A)(vi), that checked Schedule A (Form 990 or 990-EZ), Part II, line 13, 16a, or 16b, and that received from any one contributor, during the year, total contributions of the greater of (1) $5,000 or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h, or (ii) Form 990-EZ, line 1. Complete Parts I and II.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, total contributions of more than $1,000 exclusively for religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals. Complete Parts I, II, and III.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, contributions exclusively for religious, charitable, etc., purposes, but no such contributions totaled more than $1,000. If this box is checked, enter here the total contributions that were received during the year for an exclusively religious, charitable, etc., purpose. Don't complete any of the parts unless the General Rule applies to this organization because it received nonexclusively religious, charitable, etc., contributions totaling $5,000 or more during the year ......... Arrow Bullet

Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).

For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.

Cat. No. 30613XSchedule B (Form 990) (2021)

Schedule B (Form 990) (2021) Page 2

Name of organization MAYO CLINIC

Part I Contributors	Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
RESTRICTED	,	$ RESTRICTED	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 3

Name of organization MAYO CLINIC		Employer identification number 41-6011702

Part II	Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 4


Name of organization MAYO CLINIC			Employer identification number 41-6011702
Part III Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) $ Use duplicate copies of Part III if additional space is needed.

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

Schedule B (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE C
(Form 990)

Department of the Treasury
Internal Revenue Service

Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527

SchCMd Bullet

Complete if the organization is described below. SchCMd Bullet

Attach to Form 990 or Form 990-EZ.
SchCMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet

Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet

Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet

Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet

Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet

Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet

Section 501(c)(4), (5), or (6) organizations: Complete Part III.

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I-A

Complete if the organization is exempt under section 501(c) or is a section 527 organization.

Provide a description of the organization’s direct and indirect political campaign activities in Part IV. See instructions for definition of “political campaign activities."

Political campaign activity expenditures. See instructions .................................................................... SchCMd Bullet

Volunteer hours for political campaign activities. See instructions ..................................................................

Part I-B

Complete if the organization is exempt under section 501(c)(3).

Enter the amount of any excise tax incurred by the organization under section 4955 ................................ SchCMd Bullet

Enter the amount of any excise tax incurred by organization managers under section 4955 ....................... SchCMd Bullet

If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................

Yes No

Was a correction made? ......................................................................................................................

Yes No

If "Yes," describe in Part IV.

Part I-C

Complete if the organization is exempt under section 501(c), except section 501(c)(3).

Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet

Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................ SchCMd Bullet

Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b........... SchCMd Bullet

Did the filing organization file Form 1120-POL for this year? ...................................................................

Yes No

Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.

(a) Name	(b) Address	(c) EIN	(d) Amount paid from filing organization's funds. If none, enter -0-.	(e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6

For Paperwork Reduction Act Notice, see the instructions for Form 990.

Cat. No. 50084S

Schedule C (Form 990) 2021

Page 2

Part II-A

Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).

A Check SchCMd Bullet

if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN, expenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet

if the filing organization checked box A and "limited control" provisions apply.

Limits on Lobbying Expenditures (The term "expenditures" means amounts paid or incurred.)		(b) Affiliated group totals
1a	Total lobbying expenditures to influence public opinion (grass roots lobbying) ......................
b	Total lobbying expenditures to influence a legislative body (direct lobbying) ........................
c	Total lobbying expenditures (add lines 1a and 1b) ............................................................
d	Other exempt purpose expenditures ...............................................................................
e	Total exempt purpose expenditures (add lines 1c and 1d) ..................................................
f	Lobbying nontaxable amount. Enter the amount from the following table in both columns.
	If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
	Not over $500,00020% of the amount on line 1e.
	Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
	Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
	Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
	Over $17,000,000$1,000,000.

g	Grassroots nontaxable amount (enter 25% of line 1f) .................................................
h	Subtract line 1g from line 1a. If zero or less, enter -0-. ................................................
i	Subtract line 1f from line 1c. If zero or less, enter -0-. ................................................
j	If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting section 4911 tax for this year? ...................................................................................................................	Yes No

4-Year Averaging Period Under Section 501(h) (Some organizations that made a section 501(h) election do not have to complete all of the five columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
	Calendar year (or fiscal year beginning in)	(a) 2018	(b) 2019	(c) 2020	(d) 2021	(e) Total

2a	Lobbying nontaxable amount

b	Lobbying ceiling amount (150% of line 2a, column(e))

c	Total lobbying expenditures

d	Grassroots nontaxable amount

e	Grassroots ceiling amount (150% of line 2d, column (e))

f	Grassroots lobbying expenditures

Schedule C (Form 990) 2021

Page 3

Part II-B

Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).

For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.

(a)

Yes|No

(b)

Amount

During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:

Volunteers? ...........................................................................................................

Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........

Yes

Media advertisements? ...................................................................................................

Mailings to members, legislators, or the public? .............................................................................

Yes

Publications, or published or broadcast statements? ...........................................................

Yes

Grants to other organizations for lobbying purposes? ..........................................................

Direct contact with legislators, their staffs, government officials, or a legislative body? .......................

Yes

Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................

Yes

Other activities? ...................................................................................................................

Yes

192,699

Total. Add lines 1c through 1i ....................................................................................................

192,699

Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....

If "Yes," enter the amount of any tax incurred under section 4912 ...........................................

If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................

If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................

Part III-A

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).

Yes

Were substantially all (90% or more) dues received nondeductible by members? ...............................................

Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................

Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................

Part III-B

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."

Dues, assessments and similar amounts from members ......................................................................

Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).

Current year .............................................................................................................................

Carryover from last year ............................................................................................................

Total ...........................................................................................................................................

Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .

If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................

Taxable amount of lobbying and political expenditures. See Instructions .........................................

Part IV

Supplemental Information

Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.

Return Reference	Explanation
PART II-B, LINE 1:	DURING 2021, MAYO CLINIC (MAYO) OFFICIALS HAD MEETINGS AND CONTACTS WITH FEDERAL AND STATE GOVERNMENT OFFICIALS, INCLUDING MEMBERS OF CONGRESS, STATE LEGISLATURES, AND RESPECTIVE EXECUTIVE BRANCH OFFICIALS TO DISCUSS VARIOUS HEALTH CARE REFORM PROPOSALS AND PROPOSED LEGISLATION. THESE DISCUSSIONS AND MEETINGS WERE HELD IN ROCHESTER, MN AS WELL AS WASHINGTON, D.C., ST. PAUL, MN AND OTHER MAYO CLINIC SITE LOCATIONS. IN ADDITION, MAYO SENT CORRESPONDENCE TO MEMBERS, STAFF AND OTHER GOVERNMENT OFFICIALS OUTLINING MAYO'S POSITIONS AND RECOMMENDATIONS ON LEGISLATION AND PROPOSED REGULATIONS. MAYO PROVIDES INFORMATION OR EXPRESSES ITS CONCERN TO LEGISLATIVE BODIES AND GOVERNMENT OFFICIALS ON MATTERS DIRECTLY RELATED TO HEALTH, THE DELIVERY OF HEALTH CARE AND MEDICAL EDUCATION AND/OR RESEARCH. IN 2021, MAYO REPRESENTATIVES HAD SEVERAL MEETINGS WITH MEMBERS OF THE LEGISLATIVE AND EXECUTIVE BRANCHES OF GOVERNMENT TO DISCUSS ISSUES RELATING TO PATIENT CARE, EDUCATION AND RESEARCH. IN ADDITION TO CORRESPONDENCE, MAYO EXPRESSES ITS PERSPECTIVE ON POLICY ISSUES VIA EDITORIALS AND IN RESPONSES TO MEDIA INQUIRIES. ON OCCASION, MAYO'S POLICY PERSPECTIVE MAY BE INCLUDED IN THE SPEECH CONTENT OF MAYO LEADERS. THE MAJORITY OF EXPENSES RELATED TO LOBBYING ARE INCURRED BY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (MFMER), AN AFFILIATED SUPPORT ORGANIZATION OF MAYO CLINIC. IN 2021, THE EXPENSES ASSOCIATED WITH THE ABOVE LOBBYING ACTIVITIES ON BEHALF OF MAYO CLINIC (THE PARENT ORGANIZATION) WHICH ARE INCLUDED IN THIS FORM 990 ARE $965,796.
SCHEDULE C PART II-B LINE 1I	THE AMOUNT IN OTHER ACTIVITIES REPRESENTS A PORTION OF PROFESSIONAL DUES ATTRIBUTABLE TO LOBBYING.

Return Reference

Explanation

PART II-B, LINE 1:

DURING 2021, MAYO CLINIC (MAYO) OFFICIALS HAD MEETINGS AND CONTACTS WITH FEDERAL AND STATE GOVERNMENT OFFICIALS, INCLUDING MEMBERS OF CONGRESS, STATE LEGISLATURES, AND RESPECTIVE EXECUTIVE BRANCH OFFICIALS TO DISCUSS VARIOUS HEALTH CARE REFORM PROPOSALS AND PROPOSED LEGISLATION. THESE DISCUSSIONS AND MEETINGS WERE HELD IN ROCHESTER, MN AS WELL AS WASHINGTON, D.C., ST. PAUL, MN AND OTHER MAYO CLINIC SITE LOCATIONS. IN ADDITION, MAYO SENT CORRESPONDENCE TO MEMBERS, STAFF AND OTHER GOVERNMENT OFFICIALS OUTLINING MAYO'S POSITIONS AND RECOMMENDATIONS ON LEGISLATION AND PROPOSED REGULATIONS. MAYO PROVIDES INFORMATION OR EXPRESSES ITS CONCERN TO LEGISLATIVE BODIES AND GOVERNMENT OFFICIALS ON MATTERS DIRECTLY RELATED TO HEALTH, THE DELIVERY OF HEALTH CARE AND MEDICAL EDUCATION AND/OR RESEARCH. IN 2021, MAYO REPRESENTATIVES HAD SEVERAL MEETINGS WITH MEMBERS OF THE LEGISLATIVE AND EXECUTIVE BRANCHES OF GOVERNMENT TO DISCUSS ISSUES RELATING TO PATIENT CARE, EDUCATION AND RESEARCH. IN ADDITION TO CORRESPONDENCE, MAYO EXPRESSES ITS PERSPECTIVE ON POLICY ISSUES VIA EDITORIALS AND IN RESPONSES TO MEDIA INQUIRIES. ON OCCASION, MAYO'S POLICY PERSPECTIVE MAY BE INCLUDED IN THE SPEECH CONTENT OF MAYO LEADERS. THE MAJORITY OF EXPENSES RELATED TO LOBBYING ARE INCURRED BY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (MFMER), AN AFFILIATED SUPPORT ORGANIZATION OF MAYO CLINIC. IN 2021, THE EXPENSES ASSOCIATED WITH THE ABOVE LOBBYING ACTIVITIES ON BEHALF OF MAYO CLINIC (THE PARENT ORGANIZATION) WHICH ARE INCLUDED IN THIS FORM 990 ARE $965,796.

SCHEDULE C PART II-B LINE 1I

THE AMOUNT IN OTHER ACTIVITIES REPRESENTS A PORTION OF PROFESSIONAL DUES ATTRIBUTABLE TO LOBBYING.

Schedule C (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE D
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Financial Statements

Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet

Attach to Form 990.
SchDMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.

		(a) Donor advised funds
1	Total number at end of year .........	9
2	Aggregate value of contributions to (during year)	120,880
3	Aggregate value of grants from (during year)	243,183
4	Aggregate value at end of year ........	4,390,526

Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............

Yes No

Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................

Yes No

Part II

Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.

Purpose(s) of conservation easements held by the organization (check all that apply).

Preservation of land for public use (e.g., recreation or education) Preservation of an historically important land area

Protection of natural habitat Preservation of a certified historic structure

Preservation of open space

Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.


a	Total number of conservation easements ......................	2a
b	Total acreage restricted by conservation easements ....................	2b
c	Number of conservation easements on a certified historic structure included in (a) .....	2c
d	Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ...	2d

Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet

Number of states where property subject to conservation easement is located SchDMd Bullet

Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............

Yes No

Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................

Yes No

In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.

If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.

If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:

(i)

Revenue included on Form 990, Part VIII, line 1 ......................... SchDMd Bullet

(ii)

Assets included in Form 990, Part X ............................... SchDMd Bullet

If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:

Revenue included on Form 990, Part VIII, line 1 .......................... SchDMd Bullet

Assets included in Form 990, Part X ............................... SchDMd Bullet

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 52283D

Schedule D (Form 990) 2021

Page 2

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)

Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):

Public exhibition

Loan or exchange programs

Scholarly research

Other

Preservation for future generations

Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.

During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...

Yes No

Part IV

Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.

Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................

Yes No


b	If "Yes," explain the arrangement in Part XIII and complete the following table:		Amount
c	Beginning balance .............................	1c
d	Additions during the year ............................	1d
e	Distributions during the year ..........................	1e
f	Ending balance ................................	1f

Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...

Yes No

If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....

Part V

Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.

		(a) Current year	(b) Prior year	(c) Two years back	(d) Three years back	(e) Four years back

1a	Beginning of year balance ....	5,061,662,985	4,427,091,907	3,852,237,495	3,649,041,615	3,166,765,991
b	Contributions ...	90,896,164	171,083,411	155,829,477	232,064,809	207,453,772
c	Net investment earnings, gains, and losses	1,143,091,782	647,792,722	461,221,455	59,629,160	430,687,700
d	Grants or scholarships ...
e	Other expenditures for facilities and programs ...	178,299,215	184,305,055	42,196,520	88,498,089	155,865,847
f	Administrative expenses ....
g	End of year balance ......	6,117,351,716	5,061,662,985	4,427,091,907	3,852,237,495	3,649,041,616

Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:

Board designated or quasi-endowment SchDMd Bullet

47.450 %

Permanent endowment SchDMd Bullet

27.000 %

Term endowment SchDMd Bullet

25.550 %

The percentages on lines 2a, 2b, and 2c should equal 100%.

Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes

(i) Unrelated organizations .................

3a(i)

(ii) Related organizations .................

3a(ii)

If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........

Describe in Part XIII the intended uses of the organization's endowment funds.

Part VI

Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.

Description of property		(a) Cost or other basis (investment)	(b) Cost or other basis (other)	(c) Accumulated depreciation	(d) Book value

1a	Land .....	110,386,995		110,386,995
b	Buildings ....	1,933,402,534	1,205,508,138	727,894,396
c	Leasehold improvements	68,102,530	41,500,187	26,602,343
d	Equipment ....	1,592,859,701	1,090,849,771	502,009,930
e	Other .....	100,198,207		100,198,207
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..				1,467,091,871

Schedule D (Form 990) 2021

Page 3

Part VII

Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.

(a) Description of security or category (including name of security)	(b) Book value	(c) Method of valuation: Cost or end-of-year market value
(1) Financial derivatives.........
(2) Closely-held equity interests........
(3) Other (A) MAYO POOLED INVESTMENTS	14,825,293,684	F
(B)
(C)
(D)
(E)
(F)
(G)
(H)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)	14,825,293,684

Part VIII

Investments - Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.

(a) Description of investment	(b) Book value	(c) Method of valuation: Cost or end-of-year market value

(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)

Part IX

Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.

(a) Description				(b) Book value
(1)DUE FROM AFFILIATES				1,558,014,037
(2)INVESTMENTS IN SUBSIDIARIES				526,491,755
(3)CONTRIBUTED ASSETS PENDING DISPOSAL				103,008,418
(4)ART				3,167,394
(5)TRUSTS				119,699,439
(6)DEFERRED INCOME TAX ASSET				40,847,656
(7)OTHER LONG TERM ASSETS				180,473,768
(8)ASSETS HELD FOR DISSOLUTION				307,475
(9)TECH BASED VENTURES				39,942,646
(10)BOND-RELATED TRUSTEE HELD INVEST				489,938
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........				2,572,442,526

Part X

Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.

1.(a) Description of liability	(b) Book value
(1) Federal income taxes	11,125,856
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)	3,526,450,006
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII

Schedule D (Form 990) 2021

Page 4

Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total revenue, gains, and other support per audited financial statements .......		1
2	Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a	Net unrealized gains (losses) on investments ....	2a
b	Donated services and use of facilities .........	2b
c	Recoveries of prior year grants ...........	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d .....................		2e
3	Subtract line 2e from line 1..................		3
4	Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b .	4a
b	Other (Describe in Part XIII.) ...........	4b
c	Add lines 4a and 4b....................		4c
5	Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ......		5

Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total expenses and losses per audited financial statements ...........		1
2	Amounts included on line 1 but not on Form 990, Part IX, line 25:
a	Donated services and use of facilities .........	2a
b	Prior year adjustments ............	2b
c	Other losses ................	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d....................		2e
3	Subtract line 2e from line 1...................		3
4	Amounts included on Form 990, Part IX, line 25, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b ..	4a
b	Other (Describe in Part XIII.) ............	4b
c	Add lines 4a and 4b.....................		4c
5	Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ......		5

Part XIII

Supplemental Information

Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.

Return Reference	Explanation
PART III, LINE 1A:	MAYO CLINIC PERIODICALLY RECEIVES WORKS OF ART FROM VARIOUS BENEFACTORS. THESE ITEMS ARE UNIQUE IN NATURE AND ARE HELD ON DISPLAY FOR THE BENEFIT AND ENJOYMENT OF MAYO'S PATIENTS. IT IS MAYO'S POLICY TO NEITHER CAPITALIZE CONTRIBUTED WORKS OF ART, NOR RECORD THE RELATED CONTRIBUTION REVENUE. IN THE RARE OCCURRENCE THAT MAYO CLINIC COMMISSIONS ART; IT IS REFLECTED AS AN EXPENSE OR ON THE BALANCE SHEET.
PART III, LINE 4:	MAYO'S FOUNDERS RECOGNIZED THAT CARING FOR THE WHOLE PATIENT EXTENDS BEYOND TREATING PHYSICAL AILMENTS. SINCE ITS INCEPTION, MAYO HAS USED ART, ARCHITECTURE AND BEAUTY IN SURROUNDINGS TO ADDRESS THE SPIRITUAL ASPECTS OF MEDICAL CARE. BENEFACTOR GIFTS FROM PATIENTS, FRIENDS, EMPLOYEES OR ALUMNI HELP MAYO SUPPORT THE ACQUISITION OF ART USED TO HUMANIZE THE MEDICAL ENVIRONMENT AND COMPLEMENT THE BELIEF THAT RESTORING THE MIND AND SPIRIT IS AN IMPORTANT PART OF MAKING THE BODY WELL. WORKS OF ART DISPLAYED ACROSS THE MAYO CAMPUS PROVIDE BEAUTY, PRESERVATION OF HERITAGE AND RESPECT FOR THE DIVERSITY OF PATIENTS, VISITORS AND STAFF.
PART V, LINE 4:	THE ENDOWMENT FUNDS PROVIDE A STABLE FUNDING SOURCE FOR RESEARCH AND EDUCATION PROGRAMS.
PART X, LINE 2:	PORTION OF INCOME TAX FOOTNOTE FROM MAYO CLINIC CONSOLIDATED AUDITED FINANCIAL STATEMENTS: MOST OF THE INCOME RECEIVED BY THE CLINIC AND ITS SUBSIDIARIES IS EXEMPT FROM TAXATION UNDER SECTION 501(A) OF THE INTERNAL REVENUE CODE. SOME OF ITS SUBSIDIARIES ARE TAXABLE ENTITIES, AND SOME OF THE INCOME RECEIVED BY OTHERWISE EXEMPT ENTITIES IS SUBJECT TO TAXATION AS UNRELATED BUSINESS INCOME. THE CLINIC AND ITS SUBSIDIARIES FILE INCOME TAX RETURNS IN THE U.S., INCLUDING FEDERAL AND VARIOUS STATE RETURNS, AS WELL AS CERTAIN FOREIGN JURISDICTIONS. THE STATUTES OF LIMITATIONS FOR TAX YEARS 2018 THROUGH 2020 REMAIN OPEN IN MAJOR U.S. TAXING JURISDICTIONS IN WHICH THE CLINIC AND SUBSIDIARIES ARE SUBJECT TO TAXATION. THE INTERNAL REVENUE SERVICE (IRS) PERFORMED AN EXAMINATION OF THE TAX AND INFORMATION RETURNS OF THE CLINIC AND TWO SUBSIDIARIES AND ULTIMATELY ASSESSED $12 MILLION IN TAXES FOR YEARS 2003-2012. THE RESULTS OF THIS AUDIT WERE ULTIMATELY LITIGATED IN THE U.S. DISTRICT COURT. ON AUGUST 6, 2019, THE COURT ISSUED A SUMMARY JUDGMENT IN FAVOR OF THE CLINIC. THE IRS HAS APPEALED THIS DECISION. THIS RULING HAS BEEN TAKEN INTO CONSIDERATION DURING THE CLINIC'S DETERMINATION OF UNRECOGNIZED TAX BENEFITS. THE CLINIC HAS REDUCED THE RESERVE FOR UNCERTAIN TAX POSITIONS BY $7 MILLION, INCLUDING INTEREST AND PENALTIES, DURING THE YEAR ENDED DECEMBER 31, 2021. AS OF DECEMBER 31, 2021 AND 2020, THE RESERVE TOTALED $13 MILLION AND $20 MILLION, RESPECTIVELY. IT IS NOT ANTICIPATED THAT A SIGNIFICANT CHANGE IN THE RESERVE WILL OCCUR OVER THE NEXT 12 MONTHS. THE CLINIC'S PRACTICE IS TO RECOGNIZE INTEREST AND/OR PENALTIES RELATED TO INCOME TAX MATTERS IN INCOME TAX EXPENSE. AFTER THE ABOVE CONSOLIDATED AUDITED FINANCIAL STATEMENTS WERE ISSUED, THE EIGHTH CIRCUIT COURT OF APPEALS REVERSED THE AWARD OF SUMMARY JUDGMENT AND REMANDED THE CASE BACK TO THE DISTRICT COURT FOR TRIAL. THE TRIAL CONCLUDED ON APRIL 29TH, 2022, AND WE ARE AWAITING THE COURT'S DECISION.

Schedule D (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE E(Form 990)

Department of the Treasury
Internal Revenue Service

Schools

Complete if the organization answered "Yes" on Form 990,
Part IV, line 13, or Form 990-EZ, Part VI, line 48.
Right pointing arrow large image

Attach to Form 990 or Form 990-EZ.
Right pointing arrow large image

Go to www.irs.gov/Form990EZ for the latest information.

OMB No. 1545-0047 2021Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

YES

Does the organization have a racially nondiscriminatory policy toward students by statement in its charter, bylaws,

other governing instrument, or in a resolution of its governing body? . . . . . . . . . . . . . . . . . .

Yes

Does the organization include a statement of its racially nondiscriminatory policy toward students in all its

brochures, catalogues, and other written communications with the public dealing with student admissions,

programs, and scholarships? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

Has the organization publicized its racially nondiscriminatory policy on its primary publicly accessible Internet homepage at

all times during its taxable year in a manner reasonably expected to be noticed by visitors to the homepage, or through

newspaper or broadcast media during the period of solicitation for students, or during the registration period if it has no

solicitation program, in a way that makes the policy known to all parts of the general community it serves? If "Yes," please

describe. If "No," please explain. If you need more space use Part II. . . . . . . . . . . . . . . . . . .

Yes

Does the organization maintain the following?

Records indicating the racial composition of the student body, faculty, and administrative staff? . . . . . . . . .

Yes

Records documenting that scholarships and other financial assistance are awarded on a racially nondiscriminatory

basis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

Copies of all catalogues, brochures, announcements, and other written communications to the public dealing

with student admissions, programs, and scholarships? . . . . . . . . . . . . . . . . . . . . . . .

Yes

Copies of all material used by the organization or on its behalf to solicit contributions? . . . . . . . . . . . .

Yes

If you answered "No" to any of the above, please explain. If you need more space, use Part II.

Does the organization discriminate by race in any way with respect to:

Students' rights or privileges? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Admissions policies? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Employment of faculty or administrative staff? . . . . . . . . . . . . . . . . . . . . . . . . .

Scholarships or other financial assistance? . . . . . . . . . . . . . . . . . . . . . . . . . .

Educational policies? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Use of facilities? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Athletic programs? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Other extracurricular activities? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

If you answered "Yes" to any of the above, please explain. If you need more space, use Part II.

Does the organization receive any financial aid or assistance from a governmental agency? . . . . . . . . . .

Yes

Has the organization's right to such aid ever been revoked or suspended? . . . . . . . . . . . . . . . .

If you answered "Yes" to either line 6a or line 6b, explain on Part II.

Does the organization certify that it has complied with the applicable requirements of sections 4.01 through 4.05

of Rev. Proc. 75-50, 1975-2 C.B. 587, covering racial nondiscrimination? If "No," explain on Part II. . . . . . . . .

Yes

Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50085D

Schedule E (Form 990) (2021)

Page 2

Part II

Supplemental Information. Provide the explanations required by Part I, lines 3, 4d, 5h, 6b, and 7, as applicable. Also provide
any other additional information. See instructions.

Return Reference

Explanation

SCHEDULE E, PART I, LINE 3

THE RACIALLY NONDISCRIMINATORY POLICY OF THE MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE, WHICH DRAWS STUDENTS FROM ACROSS THE UNITED STATES AND AROUND THE WORLD, IS MADE AVAILABLE IN ALL OF ITS PUBLISHED DOCUMENTS AND WEBSITE TO ANY INTERESTED APPLICANTS.

SCHEDULE E, PART I, LINE 6

MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE/MAYO CLINIC RECEIVES FUNDS FROM THE STATE OF MINNESOTA FOR MAYO CLINIC ALIX SCHOOL OF MEDICINE STUDENTS WHO ARE RESIDENTS OF MINNESOTA. IN ADDITION, FEDERAL DIRECT STUDENT LOANS (SUBSIDIZED, UNSUBSIDIZED, PARENT PLUS AND GRADPLUS) ARE AVAILABLE FOR STUDENTS IN THE MAYO CLINIC ALIX SCHOOL OF MEDICINE, MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL SCIENCES AND MAYO CLINIC SCHOOL OF HEALTH SCIENCES. FINALLY, QUALIFYING UNDERGRADUATE STUDENTS IN THE MAYO CLINIC SCHOOL OF HEALTH SCIENCES ARE ELIGIBLE FOR FUNDS FOR THE FEDERAL PELL GRANT PROGRAM.

Schedule E (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE F(Form 990)

Department of the Treasury
Internal Revenue Service

Statement of Activities Outside the United States

Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16. Right pointing arrow large image

Attach to Form 990. Right pointing arrow large image

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization
MAYO CLINIC

Employer identification number

41-6011702

Part I

General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.

For grantmakers. Does the organization maintain records to substantiate the amount of its grants and

other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used

to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.

Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)

(a) Region		(b) Number of offices in the region	(c) Number of employees, agents, and independent contractors in the region	(d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region)	(e) If activity listed in (d) is a program service, describe specific type of service(s) in the region	(f) Total expenditures for and investments in the region
	CENTRAL AMERICA AND THE CARIBBEAN	0	1	TRAVEL		4,004
	EAST ASIA AND THE PACIFIC	0	1	TRAVEL		180
	EUROPE (INCLUDING ICELAND AND GREENLAND)	0	16	TRAVEL		56,292
	MIDDLE EAST AND NORTH AFRICA	0	10	TRAVEL		72,184
	NORTH AMERICA	0	7	TRAVEL		29,196
	RUSSIA AND THE NEIGHBORING STATES	0	0	TRAVEL
	SOUTH AMERICA	0	4	TRAVEL		12,048
	SOUTH ASIA	0	1	TRAVEL		2,200
	SUB-SAHARAN AFRICA	0	1	TRAVEL		681
	EAST ASIA AND THE PACIFIC	0	0	PROGRAM SERVICES	PATIENT CARE
	EUROPE (INCLUDING ICELAND AND GREENLAND)	0	5	PROGRAM SERVICES	PATIENT CARE	109,998
	MIDDLE EAST AND NORTH AFRICA	0	4	PROGRAM SERVICES	PATIENT CARE	553,366
	EUROPE (INCLUDING ICELAND AND GREENLAND)	0	2	PROGRAM SERVICES	RESEARCH	186,766
	NORTH AMERICA	0	0	PROGRAM SERVICES	EDUCATION CONFERENCE - MAYO SPONSOR
	CENTRAL AMERICA AND THE CARIBBEAN	0	0	INVESTMENTS		969,346,159
	EAST ASIA AND THE PACIFIC	0	0	INVESTMENTS		1,343,845,528
	EUROPE (INCLUDING ICELAND AND GREENLAND)	0	0	INVESTMENTS EXPENSE		14,423,325
	EUROPE (INCLUDING ICELAND AND GREENLAND)	1	0	INVESTMENTS		753,013,160
	MIDDLE EAST AND NORTH AFRICA	0	0	INVESTMENTS		119,173,074
	NORTH AMERICA	0	0	INVESTMENTS		105,337,256
	RUSSIA AND THE NEIGHBORING STATES	0	0	INVESTMENTS		3,420,706
	SOUTH AMERICA	0	0	INVESTMENTS		6,400,110
	SOUTH ASIA	0	0	INVESTMENTS		66,308,371
	SUB-SAHARAN AFRICA	0	0	INVESTMENTS		2,967,516
	EAST ASIA AND THE PACIFIC	1	6	UNRELATED BUSINESS ACTIVITY	REFERENCE LAB SALES & MARKETING	792,623
	EUROPE (INCLUDING ICELAND AND GREENLAND)	0	1	UNRELATED BUSINESS ACTIVITY	REFERENCE LAB SALES & MARKETING
	MIDDLE EAST AND NORTH AFRICA	0	4	UNRELATED BUSINESS ACTIVITY	REFERENCE LAB SALES & MARKETING	1,001,328
	NORTH AMERICA	0	8	UNRELATED BUSINESS ACTIVITY	REFERENCE LAB SALES & MARKETING	1,204,330
	SOUTH AMERICA	0	4	UNRELATED BUSINESS ACTIVITY	REFERENCE LAB SALES & MARKETING	37,837
3a	Sub-total ....	0	40			176,104
b	Total from continuation sheets to Part I ...	2	35			3,388,122,134
c	Totals (add lines 3a and 3b)	2	75			3,388,298,238

For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2021

Schedule F (Form 990) 2021

Page 2

Part II

Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.

1 (a) Name of organization		(b) IRS code section and EIN (if applicable)	(c) Region	(d) Purpose of grant	(e) Amount of cash grant	(f) Manner of cash disbursement	(g) Amount of noncash assistance	(h) Description of noncash assistance	(i) Method of valuation (book, FMV, appraisal, other)
			EAST ASIA AND THE PACIFIC		140		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		101,216		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		40,446		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		57,778		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		265,316		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		85,904		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		90,856		0
			EAST ASIA AND THE PACIFIC		29,400		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		91,638		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		86,980		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		21,355		0
			NORTH AMERICA		7,500		0
			SOUTH ASIA		55,944		0
			NORTH AMERICA		700		0
			EAST ASIA AND THE PACIFIC		124,871		0
			EAST ASIA AND THE PACIFIC		23,822		0
			NORTH AMERICA		200		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		150,000		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		192,384		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		288,798		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		84,000		0
			NORTH AMERICA		50,243		0
			NORTH AMERICA		203,097		0
			NORTH AMERICA		5,040		0
			EUROPE (INCLUDING ICELAND & GREENLAND)		92,233		0

2	Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......	0
3	Enter total number of other organizations or entities .......................	25

Schedule F (Form 990) 2021

Schedule F (Form 990) 2021Page 3

Part III

Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.

Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance		(b) Region	(c) Number of recipients	(d) Amount of cash grant	(e) Manner of cash disbursement	(f) Amount of noncash assistance	(g) Description of noncash assistance	(h) Method of valuation (book, FMV, appraisal, other)

Schedule F (Form 990) 2021

Page 4

Part IV

Foreign Forms

Schedule F (Form 990) 2021

Page 5

Part V

Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.

ReturnReference	Explanation
PART I, LINE 2:	FEDERAL AWARDS THAT ARE SUBCONTRACTED TO OTHER ORGANIZATIONS ARE REGULARLY MONITORED BY THE FILING ORGANIZATION FOR COMPLIANCE WITH EITHER THE FEDERAL REGULATIONS AND/OR THE CONTRACT PROVISIONS. SEE ALSO SCHEDULE I, PART IV FOR ADDITIONAL INFORMATION ON MAYO CLINIC'S PROCEDURES FOR MONITORING THE USE OF GRANT FUNDS AS THE SAME PROCEDURES APPLY TO DOMESTIC AND FOREIGN GRANTS. GENERAL INFORMATION ON ACTIVITIES OUTSIDE THE UNITED STATES IS REPORTED BASED ON WHERE PAYMENTS WERE REMITTED. OUR CURRENT REPORTING SYSTEM DOES NOT TRACK ACTIVITIES OUTSIDE THE UNITED STATES BY LOCATION OF SERVICE.
PART I, LINE 3:	ACCRUAL METHOD
PART III ACCOUNTING METHOD:
PART IV - FILING OF CERTAIN FOREIGN FORMS	DISCLOSURE STATEMENT RELATED TO FORMS 5713: FORM 5713 HAS BEEN FILED BY THE FOLLOWING MEMBERS OF THE CONTROLLED GROUP: MAYO CLINIC (EIN: 41-6011702) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (EIN: 41-1506440) MAYO CLINIC HEALTH SYSTEM - NORTHWEST WISCONSIN REGION, INC. (EIN: 39-0813418) DISCLOSURE STATEMENT RELATED TO FORMS 5471: UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B), THE TAXPAYER IS REQUIRED TO FILE FORMS 5471, INFORMATION RETURN OF U.S. PERSONS WITH RESPECT TO CERTAIN FOREIGN CORPORATIONS, AS A CATEGORY 4 AND 5 FILER WITH RESPECT TO THE CONTROLLED FOREIGN CORPORATIONS (CFCS). THESE FILING REQUIREMENTS ARE OR WILL BE SATISFIED THROUGH THE FILING OF FORMS 5471 FOR THESE CFCS BY OTHER U.S. TAXPAYERS IDENTIFIED BELOW WHO HAVE THE SAME FILING REQUIREMENT. TAXPAYER NAME: MAYO CLINIC ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 5471 WAS FILED: 41-6011702 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT TAXPAYER NAME: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 5471 WAS FILED: 41-1506440 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT DISCLOSURE STATEMENT RELATED TO FORMS 8865: UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B), THE TAXPAYER IS REQUIRED TO FILE FORMS 8865, INFORMATION RETURN OF U.S. PERSONS WITH RESPECT TO CERTAIN FOREIGN PARTNERSHIPS (CFPS), AS A CATEGORY 2 AND 3 FILER. THESE FILING REQUIREMENTS ARE OR WILL BE SATISFIED THROUGH THE FILING OF FORMS 8865 FOR THESE PARTNERSHIPS BY OTHER U.S. TAXPAYERS IDENTIFIED BELOW WHO HAVE THE SAME FILING REQUIREMENT. TAXPAYER NAME: MAYO CLINIC ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 8865 WAS FILED: 41-6011702 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT

Schedule F (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE G (Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information Regarding
Fundraising or Gaming Activities

Complete if the organization answered "Yes" on Form 990, Part IV, lines 17, 18, or 19, or if the organization entered more than $15,000 on Form 990-EZ, line 6a. right arrow

Attach to Form 990 or Form 990-EZ.
right arrow

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization
MAYO CLINIC

Employer identification number

41-6011702

Part I

Fundraising Activities.Complete if the organization answered "Yes" on Form 990, Part IV, line 17.

Form 990-EZ filers are not required to complete this part.

Indicate whether the organization raised funds through any of the following activities. Check all that apply.

a	Mail solicitations	e	Solicitation of non-government grants
b	Internet and email solicitations	f	Solicitation of government grants
c	Phone solicitations	g	Special fundraising events
d	In-person solicitations

Did the organization have a written or oral agreement with any individual (including officers, directors, trustees

or key employees listed in Form 990, Part VII) or entity in connection with professional fundraising services?

YesNo

If "Yes," list the 10 highest paid individuals or entities (fundraisers) pursuant to agreements under which the fundraiser is
to be compensated at least $5,000 by the organization.

(i) Name and address of individual or entity (fundraiser)		(ii) Activity	(iii) Did fundraiser have custody or control of contributions?		(iv) Gross receipts from activity	(v) Amount paid to (or retained by) fundraiser listed in col. (i)	(vi) Amount paid to (or retained by) organization
			Yes	No
	TRUESENSE MARKETING 502 KEYSTONE DRIVE WARRENDAL, PA15086	CONSULTING		No	0	549,956	0
	THE STELTER COMPANY 10435 NEW YORK AVE DES MOINES, IA50322	DIRECT MAIL SERVICES		No	0	55,165	0
	QCSS 21925 FIELD PARKWAY SUITE 210 DEER PARK, IL60010	SERVICES-THANK YOU CALLS/CARDS		No	0	12,757	0







Total . . . . . . . . . . . . . . . . . . . .						617,878

List all states in which the organization is registered or licensed to solicit contributions or has been notified it is exempt from registration or licensing.

AL, AK, AZ, AR, CA, CO, CT, DE, FL, GA, HI, ID, IL, IN, IA, KS, KY, LA, ME, MD, MA, MI, MN, MS, MO, MT, NE, NV, NH, NJ, NM, NY, NC, ND, OH, OK, OR, PA, RI, SC, SD, TN, TX, UT, VT, VA, WA, WV, WI, WY

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50083H

Schedule G (Form 990) 2021

Page 2

Part II

Fundraising Events. Complete if the organization answered "Yes" on Form 990, Part IV, line 18, or reported more than $15,000 of fundraising event contributions and gross income on Form 990-EZ, lines 1 and 6b. List events with gross receipts greater than $5,000.

		(a) Event #1 (event type)	(b) Event #2 (event type)	(c) Other events (total number)	(d) Total events (add col. (a) through col. (c))
1	Gross receipts . . . . .
2	Less: Contributions . . . .
3	Gross income (line 1 minus line 2) . . . . . .

4	Cash prizes . . . . .
5	Noncash prizes . . . .
6	Rent/facility costs . . . .
7	Food and beverages . . .
8	Entertainment . . . .
9	Other direct expenses . . .
10	Direct expense summary. Add lines 4 through 9 in column (d) . . . . . . . . . .
11	Net income summary. Subtract line 10 from line 3, column (d). . . . . . . . . .

Part III

Gaming. Complete if the organization answered "Yes" on Form 990, Part IV, line 19, or reported more than $15,000 on Form 990-EZ, line 6a.

		(a) Bingo	(b) Pull tabs/Instant bingo/progressive bingo	(c) Other gaming	(d) Total gaming (add col.(a) through col.(c))
1	Gross revenue . . . . .

2	Cash prizes . . . . .
3	Noncash prizes . . . .
4	Rent/facility costs . . . .
5	Other direct expenses . . .

Volunteer labor . . . .

	Yes %
	No

	Yes %
	No

	Yes %
	No

Direct expense summary. Add lines 2 through 5 in column (d) . . . . . . . . . . right arrow

Net gaming income summary. Subtract line 7 from line 1, column (d). . . . . . . . . right arrow

Enter the state(s) in which the organization conducts gaming activities:

Is the organization licensed to conduct gaming activities in each of these states? . . . . . . . .

YesNo

If "No," explain:

10a

Were any of the organization's gaming licenses revoked, suspended or terminated during the tax year? . . .

YesNo

If "Yes," explain:

Schedule G (Form 990) 2021

Page 3

Does the organization conduct gaming activities with nonmembers? . . . . . . . . . . .

YesNo

Is the organization a grantor, beneficiary or trustee of a trust or a member of a partnership or other entity

formed to administer charitable gaming? . . . . . . . . . . . . . . . . .

YesNo

Indicate the percentage of gaming activity conducted in:

The organization's facility . . . . . . . . . . . . . . . . . .

13a

An outside facility . . . . . . . . . . . . . . . . . . . .

13b

Enter the name and address of the person who prepares the organization's gaming/special events books and records:

Name

Address

15a

Does the organization have a contract with a third party from whom the organization receives gaming

revenue? . . . . . . . . . . . . . . . . . . . . . . . .

YesNo

If "Yes," enter the amount of gaming revenue received by the organization right arrow

$ and the

amount of gaming revenue retained by the third party right arrow

$ .

If "Yes," enter name and address of the third party:

Name

Address

Gaming manager information:

Name

Gaming manager compensation right arrow

Description of services provided right arrow

Director/officer Employee Independent contractor

Mandatory distributions:

Is the organization required under state law to make charitable distributions from the gaming proceeds to

retain the state gaming license? . . . . . . . . . . . . . . . . . . .

YesNo

Enter the amount of distributions required under state law distributed to other exempt organizations or spent

in the organization's own exempt activities during the tax year right arrow

Part IV

Supplemental Information. Provide the explanations required by Part I, line 2b, columns (iii) and (v); and Part III, lines 9, 9b, 10b, 15b, 15c, 16, and 17b, as applicable. Also provide any additional information. See instructions.

Return Reference	Explanation
SCHEDULE G, PART I, LINE 2B, COLUMN (V)	PAYMENTS MADE TO FUNDRAISERS WERE FOR SERVICES PROVIDED TO MAYO CLINIC IN RELATION TO FUNDRAISING CONDUCTED EXCLUSIVELY BY MAYO CLINIC.

Schedule G (Form 990) 2021

Additional Data

Software ID:
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Note: To capture the full content of this document, please select landscape mode (11" x 8.5") when printing.

Schedule I
(Form 990)

Department of the Treasury
Internal Revenue Service

Grants and Other Assistance to Organizations,
Governments and Individuals in the United States

Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet

Attach to Form 990.
lBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
MAYO CLINIC

Employer identification number
41-6011702

Part I

General Information on Grants and Assistance

Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................

Yes No

Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.

Part II

Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient

that received more than $5,000. Part II can be duplicated if additional space is needed.

(a) Name and address of organization or government	(b) EIN	(c) IRC section (if applicable)	(d) Amount of cash grant	(h) Purpose of grant or assistance
(1) MAYO CLINIC JACKSONVILLE 4500 SAN PABLO ROAD JACKSONVILLE,FL32224	59-3337028	501(C)(3)	243,328,986	SUPPORT CHARITABLE PROGRAMS
(2) MAYO CLINIC ARIZONA 13400 EAST SHEA BOULEVARD SCOTTSDALE,AZ85259	86-0800150	501(C)(3)	201,738,735	SUPPORT CHARITABLE PROGRAMS
(3) MCHS--SOUTHEAST MINNESOTA REGION 1000 FIRST DRIVE NW AUSTIN,MN55912	41-1404075	501(C)(3)	14,222,643	SUPPORT CHARITABLE PROGRAMS
(4) MCHS--FRANCISCAN MEDICAL CENTER INC 700 WEST AVE SOUTH LA CROSSE,WI54601	39-0806374	501(C)(3)	8,006,839	SUPPORT CHARITABLE PROGRAMS
(5) MCHS--SOUTHWEST MINNESOTA REGION 1025 MARSH STREET MANKATO,MN56001	41-1236756	501(C)(3)	3,531,711	SUPPORT CHARITABLE PROGRAMS
(6) REGEN THERANOSTICS INC 3033 41ST STREET NW STE 200 ROCHESTER,MN55901	27-1652200	-	3,486,064	SUPPORT RESEARCH PROGRAM
(7) UNIVERSITY OF CALIFORNIA SAN FRANCISCO 220 MONTGOMERY ST FL 5 SAN FRANCISCO,CA94104	94-6036493	STATE OF CA	2,365,859	SUPPORT RESEARCH PROGRAM
(8) BOSTON SCIENTIFIC CORPORATION 300 BOSTON SCIENTIFIC WAY MARLBOROUGH,MA017521234	04-2695240	-	2,053,025	SUPPORT RESEARCH PROGRAM
(9) REGENTS OF THE UNIVERSITY OF MINNESOTA 1300 S 2ND ST STE 206 MINNEAPOLIS,MN55454	41-6007513	STATE OF MN	1,865,764	SUPPORT RESEARCH PROGRAM
(10) EMORY UNIVERSITY 1599 CLIFTON ROAD 3RD FLOOR 3101 ATLANTA,GA30322	58-0566256	501(C)(3)	1,361,991	SUPPORT CHARITABLE PROGRAMS
(11) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 615 WEST 131ST STREET MC 8741 NEW YORK,NY10027	13-5598093	501(C)(3)	1,221,948	SUPPORT CHARITABLE PROGRAMS
(12) THE UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER 1515 HOLCOMBE BOULEVARD HOUSTON,TX77030	74-6001118	STATE OF TX	1,084,294	SUPPORT RESEARCH PROGRAM
(13) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 200 FIRST STREET SW ROCHESTER,MN55905	41-1506440	501(C)(3)	1,048,484	SUPPORT CHARITABLE PROGRAMS
(14) DUKE UNIVERSITY 324 BLACKWELL ST WASHIN BLDG NO 850 DURHAM,NC27701	56-0532129	501(C)(3)	1,028,759	SUPPORT CHARITABLE PROGRAMS
(15) THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON PO BOX 301418 DALLAS,TX753031418	74-1761309	STATE OF TX	915,636	SUPPORT RESEARCH PROGRAM
(16) YALE UNIVERSITY PO BOX 208239 NEW HAVEN,CT06520	06-0646973	501(C)(3)	791,435	SUPPORT CHARITABLE PROGRAMS
(17) TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 3451 WALNUT STREET SUITE 305 PHILADELPHIA,PA191046284	23-1352685	501(C)(3)	778,401	SUPPORT CHARITABLE PROGRAMS
(18) NEXUS FAMILY HEALING 505 HIGHWAY 169 N NO 500 PLYMOUTH,MN55441	41-1419064	501(C)(3)	723,333	SUPPORT CHARITABLE PROGRAMS
(19) INDIANA UNIVERSITY 1001 E THIRD STREET BLOOMINGTON,IN474057005	35-6001673	STATE OF IN	529,919	SUPPORT RESEARCH PROGRAM
(20) THE UNIVERSITY OF IOWA 105 JESSUP HALL IOWA CITY,IA52242	42-6004813	STATE OF IA	529,205	SUPPORT RESEARCH PROGRAM
(21) KAISER FOUNDATION HOSPITALS ONE KAISER PLAZA 15L OAKLAND,CA94612	94-1105628	501(C)(3)	500,629	SUPPORT CHARITABLE PROGRAMS
(22) REGENTS OF THE UNIVERSITY OF MICHIGAN 503 THOMPSON ST ANN ARBOR,MI48109	38-6006309	STATE OF MI	488,754	SUPPORT RESEARCH PROGRAM
(23) DUKE UNIVERSITY HEALTH SYSTEM INC 324 BLACKWELL ST WASHIN BLDG N DURHAM,NC27701	56-2070036	501(C)(3)	430,398	SUPPORT CHARITABLE PROGRAMS
(24) CHILDREN'S HOSPITAL LOS ANGELES 4650 SUNSET BOULEVARD LOS ANGELES,CA900270982	95-1690977	501(C)(3)	425,318	SUPPORT CHARITABLE PROGRAMS
(25) WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY 1300 YORK AVENUE NEW YORK,NY10065	13-1623978	501(C)(3)	412,277	SUPPORT CHARITABLE PURPOSE
(26) UNIVERSITY OF MIAMI PO BOX 248106 CORAL GABLES,FL33124	59-0624458	501(C)(3)	402,063	SUPPORT CHARITABLE PROGRAMS
(27) HAZELDEN BETTY FORD FOUNDATION PO BOX 11 CENTER CITY,MN55012	41-0682405	501(C)(3)	401,121	SUPPORT CHARITABLE PROGRAMS
(28) MCHS--NORTHWEST WISCONSIN REGION INC 1221 WHIPPLE STREET EAU CLAIRE,WI54703	39-0813418	501(C)(3)	363,081	SUPPORT CHARITABLE PROGRAMS
(29) GEORGIA TECH RESEARCH CORPORATION 926 DALNEY STREET NW ATLANTA,GA303320415	58-0603146	501(C)(3)	360,543	SUPPORT CHARITABLE PROGRAMS
(30) DANA-FARBER CANCER INSTITUTE INC 450 BROOKLINE AVENUE BP418 BOSTON,MA02215	04-2263040	501(C)(3)	358,367	SUPPORT CHARITABLE PROGRAMS
(31) UNIVERSITY OF UTAH 201 PRESIDENTS CIRCLE RM 411 SALT LAKE CITY,UT84112	87-6000525	STATE OF UT	355,108	SUPPORT RESEARCH PROGRAM
(32) RINCON RESEARCH CORPORATION 101 N WILMONT RD TUCSON,AZ85711	86-0465180	-	346,635	SUPPORT RESEARCH PROGRAM
(33) THOUGHT LEADERSHIP & INNOVATION FOUNDATION 1750 TYSONS BOULEVARD NO 1500 MCLEAN,VA22102	45-3090698	501(C)(3)	333,132	SUPPORT CHARITABLE PROGRAMS
(34) ARIZONA STATE UNIVERSITY PO BOX 875812 TEMPE,AZ85287	86-0196696	STATE OF AZ	322,883	SUPPORT RESEARCH PROGRAM
(35) UNIVERSITY OF WASHINGTON 4333 BROOKLYN AVE NE SEATTLE,WA98195	91-6001537	STATE OF WA	321,673	SUPPORT RESEARCH PROGRAM
(36) THE ROCKEFELLER UNIVERSITY 1230 YORK AVENUE NEW YORK,NY10065	13-1624158	501(C)(3)	316,184	SUPPORT CHARITABLE PROGRAMS
(37) JOHNS HOPKINS UNIVERSITY 3910 KESWICK ROAD NO N4327B BALTIMORE,MD21211	52-0595110	501(C)(3)	312,047	SUPPORT CHARITABLE PROGRAMS
(38) UNITED WAY OF OLMSTED COUNTY INC 903 WEST CENTER STREET NO 100 ROCHESTER,MN55902	41-0695594	501(C)(3)	307,500	SUPPORT CHARITABLE PROGRAMS
(39) TRUSTED SEMICONDUCTOR SOLUTION 7101 NORTHLAND CIR N BROOKLYN PARK,MN554281517	20-5414682	-	300,163	SUPPORT RESEARCH PROGRAM
(40) ROCHESTER DOWNTOWN ALLIANCE 311 SOUTH BROADWAY SUITE A2 ROCHESTER,MN55904	20-2435646	501(C)(6)	295,144	SUPPORT EXEMPT PURPOSE
(41) THE CHILDREN'S HOSPITAL OF PHILADELPHIA 3401 CIVIC CENTER BOULEVARD PHILADELPHIA,PA19104	23-1352166	501(C)(3)	277,486	SUPPORT CHARITABLE PROGRAMS
(42) VANDERBILT UNIVERSITY PMB 406310 2301 VANDERBILT PLACE NASHVILLE,TN37240	62-0476822	501(C)(3)	274,796	SUPPORT CHARITABLE PROGRAMS
(43) WASHINGTON UNIVERSITY 700 ROSEDALE AVENUE CB 1034 SAINT LOUIS,MO63112	43-0653611	501(C)(3)	266,762	SUPPORT CHARITABLE PROGRAMS
(44) HENNEPIN HEALTHCARE RESEARCH INSTITUTE 701 PARK AVENUE MINNEAPOLIS,MN55415	41-1677920	501(C)(3)	265,612	SUPPORT CHARITABLE PROGRAMS
(45) THE GENERAL HOSPITAL CORPORATION 399 REVOLUTION DRIVE NO 645 SOMERVILLE,MA02145	04-2697983	501(C)(3)	264,885	SUPPORT CHARITABLE PROGRAMS
(46) SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE 10901 NORTH TORREY PINES ROAD LA JOLLA,CA92037	51-0197108	501(C)(3)	263,225	SUPPORT CHARITABLE PROGRAMS
(47) SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 1275 YORK AVENUE NEW YORK,NY10065	13-1624182	501(C)(3)	250,080	SUPPORT CHARITABLE PURPOSE
(48) THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS 5323 HARRY HINES BLVD DALLAS,TX753900860	75-6002868	STATE OF TX	240,679	SUPPORT RESEARCH PROGRAM
(49) THE BRIGHAM AND WOMEN'S HOSPITAL INC 339 REVOLUTION DRIVE NO 645 SOMERVILLE,MA02145	04-2312909	501(C)(3)	227,938	SUPPORT CHARITABLE PROGRAMS
(50) UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 103 SOUTH BUILDING CAMPUS BOX 9100 CHAPEL HILL,NC27599	56-6001393	STATE OF NC	223,727	SUPPORT RESEARCH PROGRAM
(51) UNIVERSITY OF WISCONSIN-MADISON 21 N PARK STREET SUITE 6401 MADISON,WI53715	39-6006492	STATE OF WI	222,954	SUPPORT RESEARCH PROGRAM
(52) THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO 7703 FLOYD CURL DR SAN ANTONIO,TX782293900	74-1586031	STATE OF TX	216,066	SUPPORT RESEARCH PROGRAM
(53) HEALTHPARTNERS INSTITUTE 8170 33RD AVENUE SOUTH MINNEAPOLIS,MN554401309	41-1670163	501(C)(3)	215,297	SUPPORT CHARITABLE PROGRAMS
(54) UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY GARDENS UGB203 LOS ANGELES,CA90089	95-1642394	501(C)(3)	212,939	SUPPORT CHARITABLE PROGRAMS
(55) BENCHMARK ELECTRONICS INC 56 SOUTH ROCKFORD DRIVE TEMPE,AZ85281	74-2211011	-	212,780	SUPPORT RESEARCH PROGRAM
(56) BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA 151 PREM S PAUL RESEARCH CENTER LINCOLN,NE68583	47-0049123	STATE OF NE	212,756	SUPPORT RESEARCH PROGRAM
(57) THE METHODIST HOSPITAL RESEARCH INSTITUTE 6565 FANNIN ST HOUSTON,TX77030	87-0721923	501(C)(3)	207,783	SUPPORT CHARITABLE PURPOSE
(58) MAINEHEALTH 22 BRAMHALL STREET PORTLAND,ME04102	01-0238552	501(C)(3)	203,209	SUPPORT CHARITABLE PROGRAMS
(59) THE FTD DISORDERS REGISTRY LLC 2700 HORIZON DRIVE KING OF PRUSSIA,PA19406	47-3601782	501(C)(3)	197,304	SUPPORT CHARITABLE PROGRAMS
(60) NORTH CAROLINA STATE UNIVERSITY 2601 WOLF VILLAGE WAY SUITE 240 RALEIGH,NC27695	56-6000756	STATE OF NC	192,196	SUPPORT RESEARCH PROGRAM
(61) UNIVERSITY OF CHICAGO 6054 S DREXEL AVENUE CHICAGO,IL60637	36-2177139	501(C)(3)	186,255	SUPPORT CHARITABLE PROGRAMS
(62) OREGON HEALTH & SCIENCE UNIVERSITY 3181 SW SAM JACKSON PARK ROAD PORTLAND,OR97239	93-1176109	STATE OF OR	186,081	SUPPORT RESEARCH PROGRAM
(63) HENRY FORD HEALTH SYSTEM ONE FORD PLACE-5F DETROIT,MI48202	38-1357020	501(C)(3)	174,402	SUPPORT CHARITABLE PROGRAMS
(64) UNIVERSITY OF FLORIDA 207 GRINTER HALL GAINESVILLE,FL32611	59-6002052	STATE OF FL	168,737	SUPPORT RESEARCH PROGRAM
(65) MOUNTAIN PARK HEALTH CENTER 3003 NORTH CENTRAL AVENUE SUITE 160 PHOENIX,AZ85012	86-0498020	501(C)(3)	165,317	SUPPORT CHARITABLE PROGRAMS
(66) UNIVERSITY OF CALIFORNIA LOS ANGELES 10889 WILSHIRE BOULEVARD STE 700 LOS ANGELES,CA90095	95-6006143	STATE OF CA	163,365	SUPPORT RESEARCH PROGRAM
(67) TEXAS A&M UNIVERSITY 400 HARVEY MITCHELL PKY S STE 300 COLLEGE STATION,TX77845	74-6000531	STATE OF TX	157,939	SUPPORT RESEARCH PROGRAM
(68) CHILDREN'S HOSPITAL CORPORATION 300 LONGWOOD AVENUE BOSTON,MA02115	04-2774441	501(C)(3)	155,143	SUPPORT CHARITABLE PROGRAMS
(69) ALTRU HEALTH SYSTEM 1200 S COLUMBIA RD GRAND FORKS,ND582014036	45-0310462	501(C)(3)	152,498	SUPPORT CHARITABLE PROGRAMS
(70) UNIVERSITY OF PITTSBURGH 116 ATWOOD STREET SUITE 201 PITTSBURGH,PA15260	25-0965591	501(C)(3)	151,425	SUPPORT CHARITABLE PROGRAMS
(71) TRUSTEES OF BOSTON UNIVERSITY 881 COMMONWEALTH AVENUE BOSTON,MA022151303	04-2103547	501(C)(3)	148,964	SUPPORT CHARITABLE PROGRAMS
(72) UNIVERSITY OF ROCHESTER BOX 278893 ROCHESTER,NY14627	16-0743209	501(C)(3)	145,651	SUPPORT CHARITABLE PROGRAMS
(73) MINNESOTA CHILDRENS MUSEUM 10 WEST 7TH STREET ST PAUL,MN55102	41-1354181	501(C)(3)	145,000	SUPPORT CHARITABLE PROGRAMS
(74) CHANNEL ONE INC 131 35TH STREET SE ROCHESTER,MN55904	41-1379713	501(C)(3)	142,175	SUPPORT CHARITABLE PURPOSE
(75) UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DRIVE LA JOLLA,CA92093	95-6006144	STATE OF CA	140,515	SUPPORT RESEARCH PROGRAM
(76) THE UNIVERSITY OF TEXAS AT AUSTIN 110 INNER CAMPUS DRIVE AUSTIN,TX78705	74-6000203	STATE OF TX	132,936	SUPPORT RESEARCH PROGRAM
(77) ELITE TECHNICAL SERVICES INC 3281 VETERANS MEMORIAL HWY STE E-17 RONKONKOMA,NY11779	11-3125782	-	131,100	SUPPORT RESEARCH PROGRAM
(78) AMERICAN ACADEMY OF FAMILY PHYSICIANS 11400 TOMAHAWK CREEK PARKWAY LEAWOOD,KS662112672	44-0536051	501(C)(6)	128,756	SUPPORT EXEMPT PURPOSE
(79) THE SALVATION ARMY NORTHERN DIVISION 2445 PRIOR AVENUE NORTH ROSEVILLE,MN55113	41-0698597	501(C)(3)	126,967	SUPPORT CHARITABLE PROGRAMS
(80) UNIVERSITY OF MARYLAND 620 W LEXINGTON STREET BALTIMORE,MD21201	52-6002033	STATE OF MD	121,129	SUPPORT RESEARCH PROGRAM
(81) CRAIG AND FRANCES LINDNER CENTER OF HOPE 4075 OLD WESTERN ROW ROAD MASON,OH45040	13-4343743	501(C)(3)	119,580	SUPPORT CHARITABLE PROGRAMS
(82) GE PRECISION HEALTHCARE LLC 3000 N GRANDVIEW BLVD WAUKESHA,WI53188	83-0849145	-	119,480	SUPPORT RESEARCH PROGRAM
(83) AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS 9400 W HIGGINS ROAD NO 500 ROSEMONT,IL600184976	36-2110592	501(C)(3)	116,929	SUPPORT CHARITABLE PROGRAMS
(84) THE SCRIPPS RESEARCH INSTITUTE 10550 NORTH TORREY PINES ROAD LA JOLLA,CA92037	33-0435954	501(C)(3)	113,971	SUPPORT CHARITABLE PROGRAMS
(85) YALE NEW HAVEN HEALTH SERVICES CORPORATION 789 HOWARD AVENUE NEW HAVEN,CT06519	22-2529464	501(C)(3)	109,458	SUPPORT CHARITABLE PROGRAMS
(86) CITY OF HOPE NATIONAL MEDICAL CENTER 1500 EAST DUARTE ROAD DUARTE,CA91010	95-1683875	501(C)(3)	107,500	SUPPORT CHARITABLE PROGRAMS
(87) UNIVERSITY OF ALABAMA AT BIRMINGHAM 701 S 20TH ST BIRMINGHAM,AL35294	63-6005396	STATE OF AL	107,242	SUPPORT RESEARCH PROGRAM
(88) BOYS AND GIRLS CLUB OF ROCHESTER 1026 EAST CENTER STREET ROCHESTER,MN55904	41-1945875	501(C)(3)	105,000	SUPPORT CHARITABLE PROGRAMS
(89) PORTLAND STATE UNIVERSITY PO BOX 751 PORTLAND,OR97207	36-4776757	STATE OF OR	100,000	SUPPORT RESEARCH PROGRAM
(90) POSSABILITIES OF SOUTHERN MINNESOTA 1808 3RD AVENUE SE ROCHESTER,MN55904	41-0853397	501(C)(3)	100,000	SUPPORT CHARITABLE PURPOSE
(91) THE TOLEDO HOSPITAL 100 MADISON AVE TOLEDO,OH43604	34-4428256	501(C)(3)	99,048	SUPPORT CHARITABLE PROGRAMS
(92) UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS PO BOX 365067 SAN JUAN,PR009365067	66-0433762	COMMONWEALTH OF PR	99,026	SUPPORT RESEARCH PROGRAM
(93) GEORGE MASON UNIVERSITY 4400 UNIVERSITY DRIVE FAIRFAX,VA22030	54-0836354	STATE OF VA	96,287	SUPPORT RESEARCH PROGRAM
(94) THE REGENTS OF THE UNIVERSITY OF COLORADO 3100 MARINE ST RM 479 572 UCB BOULDER,CO80303	84-6000555	STATE OF CO	93,994	SUPPORT RESEARCH PROGRAM
(95) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 485 BROADWAY MAIL CODE 8838 REDWOOD CITY,CA94063	94-1156365	501(C)(3)	93,317	SUPPORT CHARITABLE PROGRAMS
(96) MPR ASSOCIATES INC 320 KING ST ALEXANDRIA,VA223143230	52-0804505	-	90,446	SUPPORT RESEARCH PROGRAM
(97) THE OHIO STATE UNIVERSITY 1960 KENNY RD COLUMBUS,OH43210	31-6025986	STATE OF OH	90,007	SUPPORT RESEARCH PROGRAM
(98) THE CLEVELAND CLINIC FOUNDATION 6801 BRECKSVILLE RD RK1-85 INDEPENDENCE,OH44131	34-0714585	501(C)(3)	89,534	SUPPORT CHARITABLE PROGRAMS
(99) WASHINGTON STATE UNIVERSITY 240 FRENCH ADMINISTRATION BLDG PULLMAN,WA99164	91-6001108	STATE OF WA	89,050	SUPPORT RESEARCH PROGRAM
(100) CANCER CENTER OF KANSAS PA 818 N EMPORIA ST STE 403 WICHITA,KS672143728	48-1181579	-	88,644	SUPPORT RESEARCH PROGRAM
(101) ROCHESTER AREA ECONOMIC DEVELOPMENT INC 220 SOUTH BROADWAY NO 100 ROCHESTER,MN55904	36-3414363	501(C)(3)	86,000	SUPPORT CHARITABLE PURPOSE
(102) ARIZONA BOARD OF REGENTS UNIVERSITY OF ARIZONA 888 NORTH EUCLID AVENUE ROOM 510 TUCSON,AZ85719	74-2652689	STATE OF AZ	85,341	SUPPORT RESEARCH PROGRAM
(103) SANSUM DIABETES RESEARCH INSTITUTE 2219 BATH STREET SANTA BARBARA,CA93105	95-1684086	501(C)(3)	84,814	SUPPORT CHARITABLE PROGRAMS
(104) MCHS--LAKE CITY 500 WEST GRANT STREET LAKE CITY,MN55041	41-1906820	501(C)(3)	83,341	SUPPORT CHARITABLE PROGRAMS
(105) UNIVERSITY OF CONNECTICUT HEALTH CENTER 263 FARMINGTON AVE FARMINGTON,CT060305335	52-1725543	STATE OF CT	82,855	SUPPORT RESEARCH PROGRAM
(106) MARY HITCHCOCK MEMORIAL HOSPITAL ONE MEDICAL CENTER DRIVE LEBANON,NH03756	02-0222140	501(C)(3)	82,782	SUPPORT CHARITABLE PROGRAMS
(107) SAFE HEALTH SYSTEMS INC 5455 WILSHIRE BLVD STE 1260 LOS ANGELES,CA900364282	84-4703739	-	82,500	SUPPORT RESEARCH PROGRAM
(108) WELLSTAR HEALTH SYSTEM INC 793 SAWYER ROAD MARIETTA,GA300622222	58-1649541	501(C)(3)	81,775	SUPPORT CHARITABLE PROGRAMS
(109) RONALD MCDONALD HOUSE OF ROCHESTER MINNESOTA INC 850 2ND ST SW ROCHESTER,MN55902	41-1344744	501(C)(3)	80,000	SUPPORT CHARITABLE PROGRAMS
(110) NORTHSHORE UNIVERSITY HEALTHSYSTEM 1301 CENTRAL STREET EVANSTON,IL60201	36-2167060	501(C)(3)	78,914	SUPPORT CHARITABLE PROGRAMS
(111) PRESIDENT AND FELLOWS OF HARVARD COLLEGE 1033 MASSACHUSETTS AVE 3RD FL CAMBRIDGE,MA02138	04-2103580	501(C)(3)	77,665	SUPPORT CHARITABLE PROGRAMS
(112) THE LANDING MN INC 718 22ND STREET NE ROCHESTER,MN55906	83-2953783	501(C)(3)	75,000	SUPPORT CHARITABLE PURPOSE
(113) ZUMBRO VALLEY HEALTH CENTER INC 343 WOOD LAKE DRIVE SE ROCHESTER,MN559046242	41-6052022	501(C)(3)	75,000	SUPPORT CHARITABLE PROGRAMS
(114) CEDARS-SINAI MEDICAL CENTER 8700 BEVERLY BOULEVARD LOS ANGELES,CA90048	95-1644600	501(C)(3)	71,200	SUPPORT CHARITABLE PROGRAMS
(115) NORTHWESTERN UNIVERSITY 633 CLARK ST EVANSTON,IL60208	36-2167817	501(C)(3)	69,228	SUPPORT CHARITABLE PROGRAMS
(116) MCHS--FAIRMONT 800 MEDICAL CENTER DRIVE PO BOX 800 800 FAIRMONT,MN56031	41-0760836	501(C)(3)	68,291	SUPPORT CHARITABLE PROGRAMS
(117) BUCK INSTITUTE FOR RESEARCH ON AGING 8001 REDWOOD BOULEVARD NOVATO,CA94945	94-3030609	501(C)(3)	65,011	SUPPORT CHARITABLE PROGRAMS
(118) LEGAL ASSISTANCE OF OLMSTED COUNTY 1700 NORTH BROADWAY NE RM/STE 124 ROCHESTER,MN55906	41-0992471	501(C)(3)	65,000	SUPPORT CHARITABLE PROGRAMS
(119) WAKE FOREST UNIVERSITY HEALTH SCIENCES MEDICAL CENTER BLVD WINSTON SALEM,NC27157	22-3849199	501(C)(3)	64,324	SUPPORT CHARITABLE PROGRAMS
(120) JEREMIAH PROGRAM 615 FIRST AVENUE NE NO 210 MINNEAPOLIS,MN55413	41-1801834	501(C)(3)	64,250	SUPPORT CHARITABLE PROGRAMS
(121) HIGH POINT UNIVERSITY ONE UNIVERSITY PARKWAY HIGH POINT,NC272680001	56-0529999	501(C)(3)	63,331	SUPPORT CHARITABLE PROGRAMS
(122) NEW YORK UNIVERSITY 105 E 17TH STREET 2ND FLOOR NEW YORK,NY10003	13-5562309	501(C)(3)	62,022	SUPPORT CHARITABLE PURPOSE
(123) MARSHFIELD CLINIC HEALTH SYSTEM INC 1000 N OAK AVENUE MARSHFIELD,WI54449	46-1495343	501(C)(3)	60,992	SUPPORT CHARITABLE PROGRAMS
(124) ROCHESTER ART CENTER 40 CIVIC CENTER DR SE ROCHESTER,MN55904	41-0799310	501(C)(3)	60,000	SUPPORT CHARITABLE PURPOSE
(125) INTERCULTURAL MUTUAL ASSISTANCE ASSOCIATION OF SEMN 2500 VALLEYHIGH DRIVE NW ROCHESTER,MN55901	41-1497753	501(C)(3)	59,776	SUPPORT CHARITABLE PROGRAMS
(126) NORTH AMERICA SCIENCE 6750 WALES ROAD NORTHWOOD,OH43619	34-1020232	-	58,710	SUPPORT RESEARCH PROGRAM
(127) CASE WESTERN RESERVE UNIVERSITY 10900 EUCLID AVENUE CLEVELAND,OH441067006	34-1018992	501(C)(3)	58,539	SUPPORT CHARITABLE PROGRAMS
(128) BEAR CREEK SERVICES INC 3108 HIGHWAY 52 N ROCHESTER,MN55901	41-1390671	501(C)(3)	58,369	SUPPORT CHARITABLE PURPOSE
(129) SAGE BIONETWORKS 2901 THIRD AVE STE 330 SEATTLE,WA98121	26-4489946	501(C)(3)	56,326	SUPPORT CHARITABLE PROGRAMS
(130) MAYO CLINIC FLORIDA 4500 SAN PABLO ROAD JACKSONVILLE,FL32224	59-0714831	501(C)(3)	55,292	SUPPORT CHARITABLE PROGRAMS
(131) OCHSNER CLINIC FOUNDATION 1514 JEFFERSON HIGHWAY BH 546 NEW ORLEANS,LA70121	72-0502505	501(C)(3)	55,000	SUPPORT CHARITABLE PROGRAMS
(132) TUFTS MEDICAL CENTER INC 800 WASHINTON STREET BOX 468 BOSTON,MA02111	04-3400617	501(C)(3)	50,597	SUPPORT CHARITABLE PROGRAMS
(133) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 506 S WRIGHT ST RM 209 URBANA,IL61801	37-6000511	STATE OF IL	50,491	SUPPORT RESEARCH PROGRAM
(134) NOVO ENGINEERING INC 1350 SPECIALTY DRIVE SUITE A VISTA,CA92081	88-0519771	-	50,312	SUPPORT RESEARCH PROGRAM
(135) EISENHOWER MEDICAL CENTER 39000 BOB HOPE DRIVE RANCHO MIRAGE,CA92270	95-6130458	501(C)(3)	50,000	SUPPORT CHARITABLE PROGRAMS
(136) HEMOPHILIA FOUNDATION OF MINNESOTA DAKOTAS INC 750 SOUTH PLAZA DRIVE NO 207 MENDOTA HEIGHTS,MN55120	41-6032276	501(C)(3)	50,000	SUPPORT CHARITABLE PROGRAMS
(137) HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC 6720A ROCKLEDGE DRIVE 100 BETHESDA,MD20817	52-1317896	501(C)(3)	49,594	SUPPORT CHARITABLE PROGRAMS
(138) SOCIETY OF CRITICAL CARE MEDICINE 500 MIDWAY DR MT PROSPECT,IL60056	23-7104387	501(C)(3)	49,547	SUPPORT CHARITABLE PROGRAMS
(139) AVERA MCKENNAN 1325 SOUTH CLIFF AVE SIOUX FALLS,SD571175045	46-0224743	501(C)(3)	49,327	SUPPORT CHARITABLE PROGRAMS
(140) MAYO CLINIC HOSPITAL-- ROCHESTER 200 FIRST STREET SW ROCHESTER,MN55905	41-0944601	501(C)(3)	47,937	SUPPORT CHARITABLE PROGRAMS
(141) CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY 1000 BLYTHE BLDV CHARLOTTE,NC28203	56-0529945	STATE OF NC	47,849	SUPPORT RESEARCH PROGRAM
(142) ST VINCENT HOSPITAL OF THE HOSPITAL SISTERS OF THE THIRD ORDER OF ST FRANCI 835 S VAN BUREN GREEN BAY,WI54301	39-0817529	501(C)(3)	47,176	SUPPORT CHARITABLE PROGRAMS
(143) THE UNIVERSITY OF CENTRAL FLORIDA BOARD OF TRUSTEES 4000 CENTRAL FLORIDA BLVD ORLANDO,FL32816	59-2924021	STATE OF FL	46,050	SUPPORT RESEARCH PROGRAM
(144) THE MEDICAL COLLEGE OF WISCONSIN INC 8701 WATERTOWN PLANK ROAD MILWAUKEE,WI53226	39-0806261	501(C)(3)	44,260	SUPPORT CHARITABLE PROGRAMS
(145) ROSWELL PARK CANCER INSTITUTE CORPORATION ELM AND CARLTON STREETS BUFFALO,NY14263	16-1552370	STATE OF NY	42,222	SUPPORT RESEARCH PROGRAM
(146) ONCOLOGY HEMATOLOGY ASSOCIATES OF CENTRAL ILLINOIS PC 8940 NORTH WOOD SAGE ROAD PEORIA,IL61615	37-1331017	-	41,615	SUPPORT RESEARCH PROGRAM
(147) AMERICAN NATIONAL RED CROSS 431 18TH STREET NW WASHINGTON,DC200065009	53-0196605	501(C)(3)	40,000	SUPPORT CHARITABLE PROGRAMS
(148) ELDER NETWORK 1130 1/2 7TH ST NW SUITE 205 ROCHESTER,MN55901	41-1704390	501(C)(3)	40,000	SUPPORT CHARITABLE PROGRAMS
(149) NAMI SOUTHEAST MINNESOTA 1700 BROADWAY AVE N SUITE 104 ROCHESTER,MN55906	36-3504277	501(C)(3)	40,000	SUPPORT CHARITABLE PROGRAMS
(150) SEATTLE CHILDREN'S HOSPITAL PO BOX 5371 MS RC-507 SEATTLE,WA98145	91-0564748	501(C)(3)	39,712	SUPPORT CHARITABLE PROGRAMS
(151) MINNESOTA HEALTHSOLUTIONS CORPORATION 861 E HENNEPIN AVE STE 440 MINNEAPOLIS,MN55414	20-4428357	-	39,347	SUPPORT RESEARCH PROGRAM
(152) UNIVERSITY OF NOTRE DAME DU LAC CONTROLLERS OFFICE 724 GRACE HALL NOTRE DAME,IN46556	35-0868188	501(C)(3)	39,160	SUPPORT CHARITABLE PROGRAMS
(153) BETH ISRAEL DEACONESS MEDICAL CENTER 330 BROOKLINE AVENUE BOSTON,MA02215	04-2103881	501(C)(3)	39,000	SUPPORT CHARITABLE PROGRAMS
(154) INDEPENDENT SCHOOL DISTRICT 535 615 7TH STREET SW ROCHESTER,MN55902	41-6002803	STATE OF MN	38,500	SUPPORT EXEMPT PURPOSE
(155) TRUSTEES OF TUFTS COLLEGE 169 HOLLAND STREET ATTN TAX DEPT SOMERVILLE,MA02144	04-2103634	501(C)(3)	38,341	SUPPORT CHARITABLE PROGRAMS
(156) BOARD OF TRUSTEES OF THE MINNESOTA STATE COLLEGES AND UNIVERSITIES 30 EAST 7TH STREET ST PAUL,MN55101	41-1687554	STATE OF MN	37,500	SUPPORT RESEARCH PROGRAM
(157) SIOUXLAND REGIONAL CANCER CENTER PO BOX 5017 SIOUX CITY,IA51102	42-1411233	501(C)(3)	37,000	SUPPORT CHARITABLE PROGRAMS
(158) MONTANA STATE UNIVERSITY 216 MONTANA HALL BOZEMAN,MT597172470	81-6010045	STATE OF MT	35,548	SUPPORT RESEARCH PROGRAM
(159) ROCHESTER SPORTS FOUNDATION 30 CIVIC CENTER DRIVE SE ROCHESTER,MN55904	84-2551350	501(C)(3)	35,000	SUPPORT RESEARCH PROGRAM
(160) SOMALI AMERICAN SOCIAL SERVICE ASSOCIATION 1700 N BROADWAY SUITE 152A ROCHESTER,MN55906	46-1751962	501(C)(3)	35,000	SUPPORT CHARITABLE PURPOSE
(161) APPLE TREE DENTAL 2442 MOUNDS VIEW BLVD MOUNDS VIEW,MN55112	36-3411437	501(C)(3)	35,000	SUPPORT CHARITABLE PROGRAMS
(162) BANNER HEALTH 2901 N CENTRAL AVE SUITE 160 PHOENIX,AZ85012	45-0233470	501(C)(3)	33,638	SUPPORT CHARITABLE PROGRAMS
(163) MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES 1275 YORK AVENUE NEW YORK,NY10065	13-1624082	501(C)(3)	33,444	SUPPORT CHARITABLE PROGRAMS
(164) HEBREW REHABILITATION CENTER 1200 CENTRE STREET BOSTON,MA02131	04-2104298	501(C)(3)	31,763	SUPPORT CHARITABLE PROGRAMS
(165) AMERICAN CANCER SOCIETY INC 250 WILLIAMS STREET NW NO 400 ATLANTA,GA30303	13-1788491	501(C)(3)	30,000	SUPPORT CHARITABLE PROGRAMS
(166) DOCS RECOVERY HOUSE 1821 RESTORATION DR SW ROCHESTER,MN55902	81-2012220	501(C)(3)	30,000	SUPPORT CHARITABLE PROGRAMS
(167) DIGNITY HEALTH 185 BERRY STREET SUITE 300 SAN FRANCISCO,CA94107	94-1196203	501(C)(3)	29,425	SUPPORT CHARITABLE PROGRAMS
(168) CHILDREN'S HOSPITAL MEDICAL CENTER 3333 BURNET AVENUE CINCINNATI,OH452293039	31-0833936	501(C)(3)	29,290	SUPPORT CHARITABLE PROGRAMS
(169) NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED MAINTAINING TH 535 EAST 70TH ST STREET NEW YORK,NY10021	13-1624135	501(C)(3)	29,030	SUPPORT CHARITABLE PROGRAMS
(170) UNIVERSITY OF MISSISSIPPI MEDICAL CENTER HOSPITAL 2500 NORTH STATE STREET JACKSON,MS39216	64-6008520	STATE OF MS	28,411	SUPPORT RESEARCH PROGRAM
(171) MAYO CLINIC 200 FIRST STREET SW ROCHESTER,MN55905	41-6011702	501(C)(3)	28,000	SUPPORT CHARITABLE PROGRAMS
(172) GIRL SCOUTS OF MN AND WI RIVER VALLEYS INC 400 ROBERT STREET SOUTH ST PAUL,MN55107	41-0693910	501(C)(3)	28,000	SUPPORT CHARITABLE PROGRAMS
(173) ALASKA NATIVE TRIBAL HEALTH CONSORTIUM 4000 AMBASSADOR DRIVE ANCHORAGE,AK99508	92-0162721	501(C)(3)	27,028	SUPPORT CHARITABLE PROGRAMS
(174) STEELE COUNTY FOOD SHELF INC 155 OAKDALE STREET OWATONNA,MN55060	41-1593592	501(C)(3)	27,000	SUPPORT CHARITABLE PURPOSE
(175) ORTHOCAROLINA RESEARCH INSTITUTE INC 2001 VAIL AVENUE NO 300 CHARLOTTE,NC28207	01-0648145	501(C)(3)	26,764	SUPPORT CHARITABLE PROGRAMS
(176) ST ELIZABETH MEDICAL CENTER INC ONE MEDICAL VILLAGE DRIVE EDGEWOOD,KY41017	61-0445850	501(C)(3)	26,085	SUPPORT CHARITABLE PROGRAMS
(177) GAMEHAVEN COUNCIL INC BOY SCOUTS OF AMERICA 607 E CENTER ST ROCHESTER,MN55904	41-0698309	501(C)(3)	25,000	SUPPORT CHARITABLE PROGRAMS
(178) AUSTIN COMMUNITY GROWTH VENTURES 329 NORTH MAIN STREET SUITE 106L AUSTIN,MN55912	47-5042107	501(C)(3)	25,000	SUPPORT CHARITABLE PROGRAMS
(179) DYSLEXIA INSTITUTE OF MN INC 2010 SCOTT RD NW ROCHESTER,MN55901	41-1633734	501(C)(3)	25,000	SUPPORT CHARITABLE PROGRAMS
(180) ACHLA ALIANZA CHICANA HISP LAT AMER ALLIANCE 1504 13TH AVE NE ROCHESTER,MN55906	43-2058621	501(C)(3)	25,000	SUPPORT CHARITABLE PURPOSE
(181) FAMILY SERVICE ROCHESTER INC 4600 18TH AVE NW ROCHESTER,MN55901	41-0883453	501(C)(3)	25,000	SUPPORT CHARITABLE PURPOSE
(182) DIVERSITY COUNCIL 1130-1/2 7TH ST NW STE 204 ROCHESTER,MN55901	41-1709139	501(C)(3)	25,000	SUPPORT CHARITABLE PROGRAMS
(183) MCHS--AUSTIN FOUNDATION 1000 FIRST DRIVE NW AUSTIN,MN55912	30-0107471	501(C)(3)	24,908	SUPPORT CHARITABLE PROGRAMS
(184) BAYLOR COLLEGE OF MEDICINE ONE BAYLOR PLAZA BCM 200 HOUSTON,TX770303498	74-1613878	501(C)(3)	24,602	SUPPORT CHARITABLE PROGRAMS
(185) CLEVELAND CLINIC FLORIDA (A NONPROFIT CORPORATION) 2950 CLEVELAND CLINIC BLVD WESTON,FL333313609	65-0003177	501(C)(3)	24,000	SUPPORT CHARITABLE PROGRAMS
(186) APTITUDE HEALTH LLC 5901 PEACHTREE DUNWOODY RD STE C200 ATLANTA,GA303286160	82-3684999	-	22,158	SUPPORT RESEARCH PROGRAM
(187) WESTAT INC 1600 RESEARCH BLVD ROCKVILLE,MD20850	84-0529566	-	21,826	SUPPORT RESEARCH PROGRAM
(188) CHARTERHOUSE INC 200 FIRST STREET SW ROCHESTER,MN55905	41-1405254	501(C)(3)	21,063	SUPPORT CHARITABLE PROGRAMS
(189) ST CLOUD HOSPITAL 1406 SITH AVENUE NORTH ST CLOUD,MN56303	41-0695596	501(C)(3)	20,989	SUPPORT CHARITABLE PROGRAMS
(190) USAGAINSTALZHEIMER'S 1101 K STREET NW NO 400 WASHINGTON,DC20005	45-0672514	501(C)(3)	20,502	SUPPORT CHARITABLE PROGRAMS
(191) THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 972 BRUSH HOLLOW ROAD WESTBURY,NY11590	11-2673595	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(192) SPORTS MENTORSHIP ACADEMY 3270 19TH ST NW SUITE 208 ROCHESTER,MN55901	06-1777757	501(C)(3)	20,000	SUPPORT CHARITABLE PURPOSE
(193) ROCHESTER AREA FOUNDATION 12 ELTON HILLS DRIVE NW ROCHESTER,MN55901	41-6017740	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(194) ROCHESTER REPERTORY 103 7TH STREET NE ROCHESTER,MN55906	41-1540218	501(C)(3)	20,000	SUPPORT CHARITABLE PURPOSE
(195) COMMUNITY FOOD RESPONSE 810 3RD AVE SE ROCHESTER,MN55904	41-1757102	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(196) EXERCISABILITIES INC 2530 N BROADWAY AVE ROCHESTER,MN55906	45-5214117	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(197) COMMUNITY DENTAL CARE 1670 BEAM AVENUE NO 204 MAPLEWOOD,MN551091159	04-3692982	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(198) CHILDRENS DENTAL HEALTH SERVICES 903 WEST CENTER STREET ROCHESTER,MN55902	20-3677586	501(C)(3)	20,000	SUPPORT CHARITABLE PROGRAMS
(199) SANFORD RESEARCH PO BOX 5039 RTE 5218 SIOUX FALLS,SD57117	46-0450378	501(C)(3)	19,536	SUPPORT CHARITABLE PROGRAMS
(200) ORLANDO HEALTH INC 1414 KUHL AVENUE MP8 ORLANDO,FL32806	59-1726273	501(C)(3)	19,007	SUPPORT CHARITABLE PROGRAMS
(201) CITY OF ROCHESTER 201 4TH STREET SE ROCHESTER,MN55904	41-6005494	CITY OF ROCHESTER	17,950	SUPPORT RESEARCH PROGRAM
(202) THE RECTOR AND VISITORS OF THE UNIVERSITY OF VIRGINIA 1001 N EMMET STREET CHARLOTTESVILLE,VA22903	54-6001796	STATE OF VA	17,907	SUPPORT RESEARCH PROGRAM
(203) BOLDER OPTIONS 2100 STEVENS AVE S MINNEAPOLIS,MN55404	41-1909408	501(C)(3)	17,700	SUPPORT CHARITABLE PURPOSE
(204) GEORGETOWN UNIVERSITY 37TH AND O STREETS NW WASHINGTON,DC20057	53-0196603	501(C)(3)	17,367	SUPPORT CHARITABLE PROGRAMS
(205) ABILITY BUILDING CENTER INC 1911 14TH STREET NW ROCHESTER,MN55901	41-0829178	501(C)(3)	16,900	SUPPORT CHARITABLE PROGRAMS
(206) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA DAVIS 1850 RESEARCH PARK DRIVE SUITE 300 DAVIS,CA95618	94-6036494	STATE OF CA	16,713	SUPPORT RESEARCH PROGRAM
(207) PROHEALTH CARE INC N17 W24100 RIVERWOOD DRIVE NO 200 WAUKESHA,WI531881131	39-1486873	501(C)(3)	16,250	SUPPORT CHARITABLE PROGRAMS
(208) DEAN HEALTH SYSTEMS INC 1808 WEST BELTLINE HIGHWAY MADISON,WI53713	39-1128616	-	16,000	SUPPORT RESEARCH PROGRAM
(209) THE CARLE FOUNDATION HOSPITAL 611 WEST PARK URBANA,IL61801	37-1119538	501(C)(3)	15,400	SUPPORT CHARITABLE PROGRAMS
(210) CONSUMERS FOR DENTAL CHOICE INC 316 F STREET NE STE 212 WASHINGTON,DC20002	52-2257385	501(C)(3)	15,000	SUPPORT CHARITABLE PROGRAMS
(211) HOME AGAIN 7720 COUNTY ROAD 126 SW BYRON,MN55920	32-0620806	501(C)(3)	15,000	SUPPORT CHARITABLE PURPOSE
(212) ROCHESTER SYMPHONY ORCHESTRA & CHORALE 1530 GREENVIEW DR SW 120 ROCHESTER,MN55902	41-1764434	501(C)(3)	15,000	SUPPORT CHARITABLE PROGRAMS
(213) WOMEN'S SHELTER INC PO BOX 457 ROCHESTER,MN55903	41-1316614	501(C)(3)	15,000	SUPPORT CHARITABLE PROGRAMS
(214) OLMSTED OUTREACH PO BOX 882 ROCHESTER,MN55903	41-1941871	501(C)(3)	15,000	SUPPORT CHARITABLE PROGRAMS
(215) INDEPENDENT SCHOOL DISTRICT 533 615 SOUTH AVE SW EYOTA,MN55934	41-6002834	STATE OF MN	15,000	SUPPORT EXEMPT PURPOSE
(216) CARNEGIE INSTITUTION OF WASHINGTON 1530 P ST NW WASHINGTON,DC200051910	53-0196523	501(C)(3)	13,820	SUPPORT CHARITABLE PROGRAMS
(217) BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON 1201 NINTH AVENUE SEATTLE,WA98101	91-0653422	501(C)(3)	13,177	SUPPORT CHARITABLE PROGRAMS
(218) AURORA RESEARCH INSTITUTE LLC 750 W VIRGINIA STREET MILWAUKEE,WI532341880	46-4361213	-	13,020	SUPPORT RESEARCH PROGRAM
(219) ADVARRA INC 6100 MERRIWEATHER DR STE 600 COLUMBIA,MD21044	31-1358981	-	12,980	SUPPORT RESEARCH PROGRAM
(220) FEEDING OUR COMMUNITIES PARTNERS 2120 HOWARD DR WEST NORTH MANKATO,MN56003	27-2374187	501(C)(3)	12,700	SUPPORT CHARITABLE PROGRAMS
(221) CONNECTIONS MINISTRY 220 E HICKORY ST MANKATO,MN56001	81-3920157	501(C)(3)	12,500	SUPPORT CHARITABLE PURPOSE
(222) RUSH UNIVERSITY MEDICAL CENTER 1700 WEST VAN BUREN STREET 265 CHICAGO,IL60612	36-2174823	501(C)(3)	12,444	SUPPORT CHARITABLE PROGRAMS
(223) HISPANIC ADVOCACY AND COMMUNITY EMPOWERMENT THROUGH RESEARCH 155 WABASHA ST S SUITE 110 SAINT PAUL,MN55107	41-1900934	501(C)(3)	12,000	SUPPORT CHARITABLE PURPOSE
(224) OHIO STATE UNIVERSITY RESEARCH FOUNDATION 1960 KENNY RD COLUMBUS,OH43210	31-6401599	501(C)(3)	11,950	SUPPORT CHARITABLE PROGRAMS
(225) DARTMOUTH-HITCHCOCK CLINIC ONE MEDICAL CENTER DRIVE LEBANON,NH03756	22-2519596	501(C)(3)	11,606	SUPPORT CHARITABLE PROGRAMS
(226) TOLEDO CLINIC INC 4235 SECOR ROAD TOLEDO,OH43623	34-0936207	-	11,115	SUPPORT RESEARCH PROGRAM
(227) INCLUSA INC 3349 CHURCH ST STE 1 STEVENS POINT,WI54481	81-3565570	501(C)(3)	11,000	SUPPORT CHARITABLE PURPOSE
(228) HMH HOSPITALS CORPORATION 1350 CAMPUS PARKWAY NEPTUNE,NJ07753	22-1487576	501(C)(3)	10,500	SUPPORT CHARITABLE PROGRAMS
(229) NEW HAMPSHIRE ONCOLOGY 200 TECHNOLOGY DRIVE HOOKSETT,NH03106	02-0335060	-	10,423	SUPPORT RESEARCH PROGRAM
(230) VIRGINIA HOSPITAL CENTER FOUNDATION 1701 NORTH GEORGE MASON DRIVE ARLINGTON,VA222053698	20-4129901	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(231) DIOCESE OF LA CROSSE 3710 EAST AVE S LA CROSSE,WI546024004	39-0807229	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(232) ELEVATEMED INC 12622 N 56TH PI SCOTTSDALE,AZ85254	83-3557457	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(233) SERVEMINNESOTA 120 SOUTH 6TH STREET NO 2260 MINNEAPOLIS,MN55402	41-2010058	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(234) MINNESOTA CANCER ALLIANCE PO BOX 64882 SAINT PAUL,MN551640882	86-3727230	-	10,000	SUPPORT EXEMPT PURPOSE
(235) COMUNIDAS LATINAS UNIDAS EN SERVICIO INC 797 EAST 7TH STREET ST PAUL,MN55106	41-1386986	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(236) UNITED WAY OF GOODHUE 413 WEST THIRD STREET RED WING,MN55066	41-6043633	501(C)(3)	10,000	SUPPORT CHARITABLE PURPOSE
(237) OKLAHOMA MEDICAL RESEARCH FOUNDATION 825 NE 13TH STREET OKLAHOMA CITY,OK73104	73-0580274	501(C)(3)	9,862	SUPPORT CHARITABLE PROGRAMS
(238) EMERGENCY COMMUNITY HELP ORGANIZATION INC 1014 SOUTH FRONT STREET MANKATO,MN56002	41-1429214	501(C)(3)	9,250	SUPPORT CHARITABLE PURPOSE
(239) MISSOURI BAPTIST MEDICAL CENTER 3015 N BALLAS ROAD ST LOUIS,MO63131	43-0652656	501(C)(3)	9,151	SUPPORT CHARITABLE PURPOSE
(240) SOUTHEASTERN MINNESOTA YOUTH ORCHESTRA INC 1001 14TH ST NW SUITE 450 ROCHESTER,MN55901	41-1427785	501(C)(3)	9,000	SUPPORT CHARITABLE PROGRAMS
(241) CUSTOMZINESCOM INC 209 E LIBERTY DR WHEATON,IL60187	36-4359600	-	8,500	SUPPORT RESEARCH PROGRAM
(242) GENEVA FOUNDATION 917 PACIFIC AVENUE NO 600 TACOMA,WA98402	91-1593913	501(C)(3)	8,006	SUPPORT CHARITABLE PROGRAMS
(243) COMMUNITY ACTION CENTER OF NORTHFIELD 1651 JEFFERSON PARKWAY NORTHFIELD,MN55057	41-0970984	501(C)(3)	8,000	SUPPORT CHARITABLE PURPOSE
(244) DAYTON CLINICAL ONCOLOGY PROGRAM INC 6480 CENTERVILLE BUSINESS PKWY DAYTON,OH45459	31-1100389	501(C)(3)	7,966	SUPPORT CHARITABLE PROGRAMS
(245) THE UNIVERSITY CORPORATION 18111 NORDHOFF STREET NORTHRIDGE,CA913308310	95-1992732	501(C)(3)	7,584	SUPPORT CHARITABLE PROGRAMS
(246) COALITION OF BLACKS AGAINST 13400 EAST SHEA BOULEVARD SCOTTSDALE,AZ85259	46-0799952	501(C)(3)	7,500	SUPPORT CHARITABLE PURPOSE
(247) HEALTH WORLD EDUCATION LTD 8601 EAST VIA DEL SOL SCOTTSDALE,AZ85255	86-0870332	501(C)(3)	7,500	SUPPORT CHARITABLE PURPOSE
(248) SAINT PAUL CHAMBER ORCHESTRA SOCIETY 408 ST PETER STREET 3RD FL ST PAUL,MN55102	41-0829498	501(C)(3)	7,500	SUPPORT CHARITABLE PURPOSE
(249) MCHS--ST JAMES 1101 MOULTON PARSONS DR PO BOX 460 ST JAMES,MN56081	41-0797368	501(C)(3)	7,338	SUPPORT CHARITABLE PROGRAMS
(250) SPECTRUM HEALTH HOSPITALS 100 MICHIGAN ST NE GRAND RAPIDS,MI49503	38-1360529	501(C)(3)	6,385	SUPPORT CHARITABLE PROGRAMS
(251) MED CITY ARTS FESTIVAL INC 611 NORTH BROADWAY ROCHESTER,MN55906	83-4311621	501(C)(3)	6,000	SUPPORT CHARITABLE PURPOSE
(252) WATONWAN COUNTY FOOD SHELF INC 113 7TH ST S PO BOX 123 ST JAMES,MN56081	41-1446978	501(C)(3)	6,000	SUPPORT CHARITABLE PURPOSE
(253) MOREHOUSE SCHOOL OF MEDICINE 720 WESTVIEW DRIVE SW ATLANTA,GA30310	58-1438873	501(C)(3)	5,881	SUPPORT CHARITABLE PROGRAMS
(254) THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND 6823 ST CHARLES AVENUE NEW ORLEANS,LA70118	72-0423889	501(C)(3)	5,644	SUPPORT CHARITABLE PROGRAMS
(255) PROVIDENCE PORTLAND MEDICAL CENTER PO BOX 13993 PORTLAND,OR972130933	93-0386906	501(C)(3)	5,577	SUPPORT CHARITABLE PROGRAMS

Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image

230

Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50055P

Schedule I (Form 990) 2021

Page 2

Part III

Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance	(b) Number of recipients	(c) Amount of cash grant	(d) Amount of noncash assistance	(e) Method of valuation (book, FMV, appraisal, other)	(f) Description of noncash assistance

(1) SCHOLARSHIPS	909	14,880,154
(2) MEDICAL STUDENT STIPENDS	540	10,586,738
(3) RESEARCH GRANT SUBAWARDS	0	0
(4) CHARITABLE SUPPORT OF INDIVIDUALS	27	59,755
(4)
(5)
(6)
(7)

Part IV

Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.

Return Reference

Explanation

PART I, LINE 2:

AS A PRIVATE TRUST FOR THE PUBLIC GOOD, MAYO IS DEDICATED TO GIVING BACK TO THE COMMUNITIES IN WHICH ITS EMPLOYEES LIVE AND WORK. MAYO INVESTS RESOURCES RESPONSIBLY TO PRODUCE THE BEST OUTCOMES FOR PATIENT CARE, EDUCATION, RESEARCH, COMMUNITY ENRICHMENT AND SUSTAINABILITY. GRANT APPLICATIONS ARE REVIEWED AND PRIORITIZED IN HOW THEY: -ADDRESS SIGNIFICANT AND EMERGENT COMMUNITY NEEDS -ALIGN WITH MAYO'S MISSION -IMPROVE HEALTH OF INDIVIDUALS IN THE COMMUNITY -DEMONSTRATE PARTNERSHIP AND COLLABORATION BUILDING -ENABLE LONG TERM CAPACITY BUILDING AND SUSTAINABILITY -REDUCE DISPARITIES AND INEQUITIES RELATED TO ACCESS TO HEALTH AND WELLNESS MONITORING OF GRANTS GIVEN IS DEPENDENT ON TYPE. LARGER MULTI-YEAR AND CAPITAL GRANTS ARE MONITORED FOR ACHIEVEMENT OF STATED GOALS WITHIN THE GRANT AGREEMENT. SINGLE-YEAR OPERATIONAL AND PROGRAMMATIC GRANTS ARE NOT MONITORED AFTER THE FUNDS HAVE BEEN DISBURSED; HOWEVER, ADDITIONAL FUNDING REQUESTS ARE CONSIDERED BASED ON USE AND OUTCOMES OF PREVIOUSLY AWARDED GRANTS. FEDERAL AWARDS THAT ARE SUBCONTRACTED TO INDIVIDUALS AND OTHER ORGANIZATIONS ARE MONITORED BY MAYO AS PRESCRIBED IN TITLE 2 U.S. CODE OF FEDERAL REGULATIONS PART 200, UNIFORM ADMINISTRATIVE REQUIREMENTS, COST PRINCIPLES, AND AUDIT REQUIREMENTS FOR FEDERAL AWARDS (UNIFORM GUIDANCE), SUBPART D-SUBRECIPIENT MONITORING AND MANAGEMENT 200.331 REQUIREMENTS FOR PASS-THROUGH ENTITIES. SHORT-TERM FINANCIAL ASSISTANCE AND SUPPORT IS PROVIDED TO EMPLOYEES AND INDIVIDUALS EXPERIENCING TEMPORARY HARDSHIPS. GRANTS ARE PROVIDED BASED ON A PROVEN NEED AND ARE NOT MONITORED. MEDICAL STUDENT STIPENDS ARE PAID TO THE STUDENTS OF THE MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE TO HELP OFFSET THE COST OF THE STUDENT'S LIVING EXPENSES AND ARE NOT MONITORED. MERIT-BASED AND NEEDS-BASED SCHOLARSHIPS AND GRANTS ARE AWARDED TO INDIVIDUALS PURSUING A DEGREE IN A HEALTHCARE FIELD AND ARE CONTINGENT UPON ON-GOING SATISFACTORY ACADEMIC PROGRESS.

Schedule I (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule J
(Form 990)

Department of the Treasury
Internal Revenue Service

Compensation Information

For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet

Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet

Attach to Form 990.
SchJMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Questions Regarding Compensation

Yes

Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.

First-class or charter travel Housing allowance or residence for personal use

Travel for companions Payments for business use of personal residence

Tax idemnification and gross-up payments Health or social club dues or initiation fees

Discretionary spending account Personal services (e.g., maid, chauffeur, chef)

If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .....

Yes

Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ....

Yes

Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.

Compensation committee Written employment contract

Independent compensation consultant Compensation survey or study

Form 990 of other organizations Approval by the board or compensation committee

During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:

Receive a severance payment or change-of-control payment? .............

Yes

Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........

Yes

Participate in, or receive payment from, an equity-based compensation arrangement? .........

Yes

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.

Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:

The organization? ....................

Any related organization? .......................

If "Yes," on line 5a or 5b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:

The organization? ..................

Any related organization? ......................

If "Yes," on line 6a or 6b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............

Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................

If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50053T

Schedule J (Form 990) 2021

Page 2

Part II

Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.

For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.

(A) Name and Title		(B) Breakdown of W-2, 1099-MISC compensation, and/or 1099-NEC			(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation in column (B) reported as deferred on prior Form 990
(A) Name and Title		(i) Base compensation	(ii) Bonus & incentive compensation	(iii) Other reportable compensation	(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)
1FARRUGIA MD GIANRICO TRUSTEE/PRESIDENT/CEO	(i) (ii)	0 ------------- 2,712,368	0 ------------- 0	0 ------------- 676,292	0 ------------- 58,225	0 ------------- 38,289	0 ------------- 3,485,174	0 ------------- 0
2BOLTON JEFFREY W TRUSTEE/VP	(i) (ii)	0 ------------- 1,515,983	0 ------------- 0	0 ------------- 561,212	0 ------------- 6,362	0 ------------- 28,161	0 ------------- 2,111,718	0 ------------- 0
3THIELEN MD KENT R TRUSTEE/VP	(i) (ii)	0 ------------- 1,448,823	0 ------------- 0	0 ------------- 248,989	0 ------------- 59,222	0 ------------- 34,464	0 ------------- 1,791,498	0 ------------- 0
4GRAY MD RICHARD J TRUSTEE/VP	(i) (ii)	0 ------------- 1,446,958	0 ------------- 0	0 ------------- 247,461	0 ------------- 53,384	0 ------------- 32,914	0 ------------- 1,780,717	0 ------------- 0
5KRAUSS MD WILLIAM E PHYSICIAN	(i) (ii)	1,171,862 ------------- 0	0 ------------- 0	251,774 ------------- 0	61,912 ------------- 0	27,574 ------------- 0	1,513,122 ------------- 0	0 ------------- 0
6DAHLEN DENNIS E CFO	(i) (ii)	0 ------------- 1,240,330	0 ------------- 0	0 ------------- 138,291	0 ------------- 56,218	0 ------------- 35,820	0 ------------- 1,470,659	0 ------------- 0
7LANZINO MD GIUSEPPE PHYSICIAN	(i) (ii)	1,166,872 ------------- 0	0 ------------- 0	185,757 ------------- 0	52,444 ------------- 0	33,592 ------------- 0	1,438,665 ------------- 0	0 ------------- 0
8PICHELMANN MD MARK A CHAIR-NWWI NEUROSURGERY	(i) (ii)	1,173,347 ------------- 0	0 ------------- 0	183,955 ------------- 0	43,080 ------------- 0	31,746 ------------- 0	1,432,128 ------------- 0	0 ------------- 0
9MURPHY JOSHUA B SECY	(i) (ii)	0 ------------- 1,104,117	0 ------------- 0	0 ------------- 209,978	0 ------------- 58,717	0 ------------- 37,917	0 ------------- 1,410,729	0 ------------- 0
10HARPER JR MD CHARLES M TRUSTEE	(i) (ii)	950,593 ------------- 0	0 ------------- 0	405,487 ------------- 0	11,600 ------------- 0	26,739 ------------- 0	1,394,419 ------------- 0	0 ------------- 0
11MEYER MD FREDRIC B FORMER KEY EMPLOYEE	(i) (ii)	0 ------------- 1,101,859	0 ------------- 0	0 ------------- 239,824	0 ------------- 11,600	0 ------------- 37,392	0 ------------- 1,390,675	0 ------------- 0
12CLARKE MD MICHELLE J PHYSICIAN	(i) (ii)	1,169,572 ------------- 0	0 ------------- 0	123,315 ------------- 0	48,654 ------------- 0	27,802 ------------- 0	1,369,343 ------------- 0	0 ------------- 0
13MARSH MD W RICHARD DIR-SPINE CENTER	(i) (ii)	1,092,941 ------------- 0	0 ------------- 0	236,733 ------------- 0	11,600 ------------- 0	26,778 ------------- 0	1,368,052 ------------- 0	0 ------------- 0
14GORMAN PAUL A TREASURER/ASST TREASURER	(i) (ii)	0 ------------- 786,080	0 ------------- 290,952	0 ------------- 111,371	0 ------------- 57,730	0 ------------- 32,398	0 ------------- 1,278,531	0 ------------- 0
15GORES MD GREGORY J EXECUTIVE DEAN OF RESEARCH	(i) (ii)	1,033,286 ------------- 0	0 ------------- 0	210,613 ------------- 0	0 ------------- 0	29,298 ------------- 0	1,273,197 ------------- 0	0 ------------- 0
16OTLEY MD CLARK C PHYSICIAN	(i) (ii)	857,964 ------------- 0	0 ------------- 0	193,110 ------------- 0	57,571 ------------- 0	35,485 ------------- 0	1,144,130 ------------- 0	0 ------------- 0
17AMMASH MD NASER M FORMER KEY EMPLOYEE	(i) (ii)	0 ------------- 692,822	0 ------------- 0	0 ------------- 370,757	0 ------------- 56,242	0 ------------- 22,217	0 ------------- 1,142,038	0 ------------- 0
18WILLIAMSON MARY J VICE CHAIR/CAO-MCHS	(i) (ii)	884,867 ------------- 0	0 ------------- 0	152,711 ------------- 0	45,153 ------------- 0	34,229 ------------- 0	1,116,960 ------------- 0	0 ------------- 0
19WILLIAMS MD AMY W TRUSTEE	(i) (ii)	0 ------------- 890,411	0 ------------- 0	0 ------------- 140,296	0 ------------- 74,379	0 ------------- 7,940	0 ------------- 1,113,026	0 ------------- 0
20ZORN CHRISTINA K TRUSTEE/VP/ASST SECY	(i) (ii)	0 ------------- 832,853	0 ------------- 30,000	0 ------------- 135,182	0 ------------- 49,370	0 ------------- 32,595	0 ------------- 1,080,000	0 ------------- 0
21MENKOSKY PAULA E ASST SECY	(i) (ii)	0 ------------- 804,590	0 ------------- 0	0 ------------- 135,686	0 ------------- 53,474	0 ------------- 32,479	0 ------------- 1,026,229	0 ------------- 0
22CALLSTROM MD MATTHEW R CHAIR-DEPT OF RADIOLOGY	(i) (ii)	741,007 ------------- 0	0 ------------- 0	162,122 ------------- 0	62,787 ------------- 0	25,105 ------------- 0	991,021 ------------- 0	0 ------------- 0
23SHAH MD VIJAY CHAIR-ROCH INTERN MED	(i) (ii)	745,958 ------------- 0	0 ------------- 0	154,880 ------------- 0	55,135 ------------- 0	33,004 ------------- 0	988,977 ------------- 0	0 ------------- 0
24HEBL MD JAMES R FORMER KEY EMPLOYEE	(i) (ii)	757,507 ------------- 0	0 ------------- 0	122,092 ------------- 0	43,936 ------------- 0	32,334 ------------- 0	955,869 ------------- 0	0 ------------- 0
25RIHAL MD CHARANJIT S TRUSTEE	(i) (ii)	681,863 ------------- 0	0 ------------- 0	166,025 ------------- 0	63,426 ------------- 0	32,513 ------------- 0	943,827 ------------- 0	0 ------------- 0
26KHAN RITA G FORMER KEY EMPLOYEE	(i) (ii)	0 ------------- 715,331	0 ------------- 100,000	0 ------------- 23,138	0 ------------- 51,810	0 ------------- 3,322	0 ------------- 893,601	0 ------------- 0
27FONSECA MD RAFAEL TRUSTEE	(i) (ii)	0 ------------- 604,348	0 ------------- 0	0 ------------- 194,098	0 ------------- 47,461	0 ------------- 35,157	0 ------------- 881,064	0 ------------- 0
28WALD MD JOHN T PHYSICIAN	(i) (ii)	652,427 ------------- 0	0 ------------- 0	107,953 ------------- 0	65,545 ------------- 0	33,994 ------------- 0	859,919 ------------- 0	0 ------------- 0
29CAMILLERI MD MICHAEL FORMER KEY EMPLOYEE	(i) (ii)	617,405 ------------- 0	0 ------------- 0	203,709 ------------- 0	0 ------------- 0	28,307 ------------- 0	849,421 ------------- 0	0 ------------- 0
30MORICE MD WILLIAM G CHAIR-LAB MED & PATH	(i) (ii)	669,432 ------------- 0	0 ------------- 0	82,181 ------------- 0	58,887 ------------- 0	32,058 ------------- 0	842,558 ------------- 0	0 ------------- 0
31LUETMER MD PATRICK H FORMER KEY EMPLOYEE	(i) (ii)	653,427 ------------- 0	0 ------------- 0	121,422 ------------- 0	29,466 ------------- 0	33,046 ------------- 0	837,361 ------------- 0	0 ------------- 0
32KENDRICK MD MICHAEL L CHIAR-SURGERY	(i) (ii)	637,779 ------------- 0	0 ------------- 0	100,698 ------------- 0	49,330 ------------- 0	31,970 ------------- 0	819,777 ------------- 0	0 ------------- 0
33LEIBOVICH MD BRADLEY C PHYSICIAN	(i) (ii)	609,073 ------------- 0	0 ------------- 0	91,058 ------------- 0	54,704 ------------- 0	31,893 ------------- 0	786,728 ------------- 0	0 ------------- 0
34LOFTUS MD CONOR G FORMER KEY EMPLOYEE	(i) (ii)	629,075 ------------- 0	0 ------------- 0	72,615 ------------- 0	49,065 ------------- 0	31,915 ------------- 0	782,670 ------------- 0	0 ------------- 0
35HOFFMAN III HARRY N FORMER OFFICER	(i) (ii)	0 ------------- 269,390	0 ------------- 315,003	0 ------------- 167,343	0 ------------- 9,292	0 ------------- 11,346	0 ------------- 772,374	0 ------------- 0
36DOWDY MD SEAN C CHIEF VALUE OFFICER	(i) (ii)	601,808 ------------- 0	0 ------------- 0	67,254 ------------- 0	50,463 ------------- 0	34,326 ------------- 0	753,851 ------------- 0	0 ------------- 0
37GERTZ MD MORIE A FORMER KEY EMPLOYEE	(i) (ii)	488,466 ------------- 0	0 ------------- 0	193,585 ------------- 0	11,600 ------------- 0	25,205 ------------- 0	718,856 ------------- 0	0 ------------- 0
38CIMA MD ROBERT R PHYSICIAN	(i) (ii)	548,258 ------------- 0	0 ------------- 0	81,079 ------------- 0	50,852 ------------- 0	29,803 ------------- 0	709,992 ------------- 0	0 ------------- 0
39BERRY MD DANIEL J TRUSTEE	(i) (ii)	497,082 ------------- 0	0 ------------- 0	149,189 ------------- 0	33,463 ------------- 0	21,673 ------------- 0	701,407 ------------- 0	0 ------------- 0
40FRANK MD IGOR PHYSICIAN	(i) (ii)	555,227 ------------- 0	0 ------------- 0	60,868 ------------- 0	48,898 ------------- 0	31,715 ------------- 0	696,708 ------------- 0	0 ------------- 0
41GALANIS MD EVANTHIA EXECUTIVE DEAN OF DEVELOPMENT	(i) (ii)	533,931 ------------- 0	0 ------------- 0	65,278 ------------- 0	47,624 ------------- 0	31,633 ------------- 0	678,466 ------------- 0	0 ------------- 0
42OKUNO MD SCOTT H FORMER KEY EMPLOYEE	(i) (ii)	520,126 ------------- 0	0 ------------- 0	66,624 ------------- 0	61,356 ------------- 0	29,076 ------------- 0	677,182 ------------- 0	0 ------------- 0
43BROWN MD MICHAEL J PHYSICIAN	(i) (ii)	510,765 ------------- 0	10,000 ------------- 0	66,549 ------------- 0	50,908 ------------- 0	34,331 ------------- 0	672,553 ------------- 0	0 ------------- 0
44KHAN MD AMIR R PHYSICIAN	(i) (ii)	518,970 ------------- 0	0 ------------- 0	66,184 ------------- 0	54,854 ------------- 0	31,592 ------------- 0	671,600 ------------- 0	0 ------------- 0
45MCLAUGHLIN MD SARAH A TRUSTEE	(i) (ii)	0 ------------- 585,228	0 ------------- 0	0 ------------- 38,434	0 ------------- 40,679	0 ------------- 7,005	0 ------------- 671,346	0 ------------- 0
46DIDEHBAN ROSHANAK TRUSTEE	(i) (ii)	577,213 ------------- 0	0 ------------- 0	39,766 ------------- 0	37,059 ------------- 0	11,525 ------------- 0	665,563 ------------- 0	0 ------------- 0
47DIASIO MD ROBERT B PHYSICIAN	(i) (ii)	509,164 ------------- 0	0 ------------- 0	122,756 ------------- 0	101 ------------- 0	27,704 ------------- 0	659,725 ------------- 0	0 ------------- 0
48PETERS MD STEVE G PHYSICIAN	(i) (ii)	516,347 ------------- 0	0 ------------- 0	75,350 ------------- 0	11,600 ------------- 0	26,997 ------------- 0	630,294 ------------- 0	0 ------------- 0
49FRANCIS JAMES R ASST TREASURER	(i) (ii)	0 ------------- 473,471	0 ------------- 0	0 ------------- 52,748	0 ------------- 71,556	0 ------------- 27,712	0 ------------- 625,487	0 ------------- 0
50GAZELKA MD HALENA M PHYSICIAN	(i) (ii)	503,095 ------------- 0	0 ------------- 0	34,428 ------------- 0	50,856 ------------- 0	26,443 ------------- 0	614,822 ------------- 0	0 ------------- 0
51WHITED MD BRIAN L FORMER KEY EMPLOYEE	(i) (ii)	112,993 ------------- 357,101	0 ------------- 0	55,403 ------------- 3,197	58,379 ------------- 0	6,340 ------------- 18,999	233,115 ------------- 379,297	0 ------------- 0
52HORLOCKER MD TERESE T PHYSICIAN	(i) (ii)	511,195 ------------- 0	0 ------------- 0	65,103 ------------- 0	12 ------------- 0	24,967 ------------- 0	601,277 ------------- 0	0 ------------- 0
53LUCCHINETTI MD CLAUDIA F TRUSTEE	(i) (ii)	451,812 ------------- 0	0 ------------- 0	43,283 ------------- 0	62,331 ------------- 0	31,393 ------------- 0	588,819 ------------- 0	0 ------------- 0
54HAYES MD SHARONNE N FORMER KEY EMPLOYEE	(i) (ii)	393,641 ------------- 0	0 ------------- 0	108,725 ------------- 0	58,429 ------------- 0	27,376 ------------- 0	588,171 ------------- 0	0 ------------- 0
55KRAHN MD LOIS E TRUSTEE	(i) (ii)	0 ------------- 411,629	0 ------------- 0	0 ------------- 66,492	0 ------------- 63,205	0 ------------- 32,506	0 ------------- 573,832	0 ------------- 0
56NARR MD BRADLY J FORMER KEY EMPLOYEE	(i) (ii)	400,343 ------------- 0	0 ------------- 0	107,859 ------------- 0	0 ------------- 0	27,439 ------------- 0	535,641 ------------- 0	0 ------------- 0
57DIETER HEIDI L CHIEF RESEARCH OFFICER	(i) (ii)	431,968 ------------- 0	0 ------------- 0	17,803 ------------- 0	47,985 ------------- 0	11,681 ------------- 0	509,437 ------------- 0	0 ------------- 0
58WARNER MD MARK A FORMER KEY EMPLOYEE	(i) (ii)	299,930 ------------- 0	0 ------------- 0	148,884 ------------- 0	11,600 ------------- 0	24,569 ------------- 0	484,983 ------------- 0	0 ------------- 0
59HAEFLINGER RICKY J ASST TREASURER	(i) (ii)	244,757 ------------- 0	137,053 ------------- 0	58,125 ------------- 0	562 ------------- 0	4,236 ------------- 0	444,733 ------------- 0	0 ------------- 0
60HUBERT SHERRY L ASST SECY	(i) (ii)	0 ------------- 343,973	0 ------------- 0	0 ------------- 7,536	0 ------------- 53,754	0 ------------- 33,751	0 ------------- 439,014	0 ------------- 0
61GOSTOUT MD BOBBIE S TRUSTEE/VP	(i) (ii)	0 ------------- 59,560	0 ------------- 0	0 ------------- 375,215	0 ------------- 269	0 ------------- 3,197	0 ------------- 438,241	0 ------------- 0
62GREENE MD EDDIE L TRUSTEE	(i) (ii)	310,889 ------------- 0	0 ------------- 0	31,401 ------------- 0	62,492 ------------- 0	27,079 ------------- 0	431,861 ------------- 0	0 ------------- 0
63NORBY SUSAN M FORMER OFFICER	(i) (ii)	0 ------------- 333,209	0 ------------- 0	0 ------------- 14,931	0 ------------- 48,427	0 ------------- 28,838	0 ------------- 425,405	0 ------------- 0
64HADAWAY CHERYL J FORMER KEY EMPLOYEE	(i) (ii)	265,240 ------------- 0	0 ------------- 0	126,645 ------------- 0	11,600 ------------- 0	10,502 ------------- 0	413,987 ------------- 0	0 ------------- 0
65LOCKETT KEVIN M FORMER OFFICER	(i) (ii)	0 ------------- 126,474	0 ------------- 0	0 ------------- 144,450	0 ------------- 54,308	0 ------------- 15,410	0 ------------- 340,642	0 ------------- 0
66BROWN WILLIAM A ASST TREASURER	(i) (ii)	0 ------------- 252,693	0 ------------- 0	0 ------------- 4,169	0 ------------- 0	0 ------------- 26,916	0 ------------- 283,778	0 ------------- 0

Schedule J (Form 990) 2021

Page 3

Part III

Supplemental Information

Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.

Return Reference

Explanation

PART I, LINE 1A

EXTERNAL TRUSTEES MAY BE REIMBURSED FOR TRAVEL EXPENSES. SUCH EXPENSES WOULD BE ACTUAL TRAVEL EXPENSES (WHICH COULD INCLUDE FIRST CLASS OR CHARTER TRAVEL)AND ARE BASED ON BUSINESS NEED. IN 2021, DANIEL J.BERRY M.D., ROSHANAK DIDEHBAN, EVANTHIA GALANIS M.D. AND GREGORY J. GORES M.D. WERE PROVIDED BUSINESS/FIRST-CLASS AND/OR CHARTER TRAVEL JUSTIFIED BY BUSINESS NEED. THE TRAVEL WAS NOT TREATED AS TAXABLE COMPENSATION AS ALL FLIGHTS WERE BUSINESS RELATED. BUSINESS/FIRST-CLASS AND CHARTER TRAVEL IS AVAILABLE BASED ON DEMONSTRATED BUSINESS NEED. IN ADDITION TO ALL REGULAR TRAVEL APPROVAL AND DOCUMENTATION PROCESSES, BUSINESS/FIRST-CLASS AND CHARTER TRAVEL REQUIRE SEPARATE DOCUMENTATION OF BUSINESS NEED, APPROVAL BY SENIOR LEADERSHIP, AND OVERSIGHT REVIEW BY TRIP ACCOUNTING MANAGER AS DELEGATED BY THE MAYO CLINIC TRIP AND TRAVEL COMMITTEE. TRAVEL FOR COMPANIONS IS AVAILABLE TO ALL TRUSTEES AND EX-OFFICIOS SO THAT SPOUSES CAN ACCOMPANY THEM TO THE SITE OF BOARD MEETINGS AND FOR OTHER BUSINESS RELATED PURPOSES. IN 2021, KATHERINE BAICKER, DOUGLAS M. BAKER JR., CLAUDIA F. LUCCHINETTI M.D., MICHAEL K. POWELL, CHARANJIT S. RIHAL M.D. AND ROBIN R. ROBERTS RECEIVED SPOUSAL TRAVEL, WHICH WAS GROSSED UP AND TREATED AS TAXABLE INCOME. PURSUANT TO INSTITUTIONAL POLICIES, CERTAIN AWARDS HAVE A TAX GROSS-UP APPLIED IN ORDER TO NOT DIMINISH THE RECOGNITION AND CELEBRATORY NATURE OF THE AWARD. ONE OR MORE LISTED PERSONS RECEIVED AN AWARD, WHICH WAS TREATED AS TAXABLE COMPENSATION TO THE INDIVIDUALS. THE PERSONAL SERVICES THAT WERE PROVIDED ARE INCOME TAX PREPARATION SERVICES THAT, IN ACCORDANCE WITH MAYO POLICY, ARE AVAILABLE TO MAYO CLINIC VOTING/CONSULTING STAFF. ONE OR MORE LISTED PERSONS RECEIVED THIS SERVICE, WHICH WAS TREATED AS TAXABLE COMPENSATION TO THE INDIVIDUALS.

PART I, LINES 4A-C

THE FOLLOWING INDIVIDUAL RECEIVED A PAYMENT PER A SEPARATION AGREEMENT. THE AMOUNT IS TAXABLE TO THE EMPLOYEE AND INCLUDED IN SCHEDULE J, PART II, COLUMN (B)(III). KEVIN M. LOCKETT $143,000 THIS ENTITY OR ITS AFFILIATE HAS A SUPPLEMENTAL RETIREMENT PLAN (SRP) DESIGNED TO ROUGHLY APPROXIMATE AN EXTENSION OF THE BENEFITS UNDER THE MAYO PENSION PLAN TO INCOME ABOVE THE INTERNAL REVENUE CODE QUALIFIED PLAN LIMIT IN SECTION 401(A)(17). STARTING JANUARY 1, 2011, ALL SRP BENEFITS ARE PAID AS AN ANNUAL TAXABLE CASH PAYMENT. THE FOLLOWING INDIVIDUALS PARTICIPATED IN OR RECEIVED A PAYMENT FROM THE SUPPLEMENTAL RETIREMENT PLAN. AMOUNTS ARE INCLUDED IN SCHEDULE J, PART II, COLUMN (B)(III). AMMASH M.D., NASER M. $110,604 BERRY M.D., DANIEL J. $124,881 BOLTON, JEFFREY W. $282,321 BROWN M.D., MICHAEL J. $62,718 CALLSTROM M.D., MATTHEW R. $133,069 CAMILLERI M.D., MICHAEL $113,750 CIMA M.D., ROBERT R. $72,802 CLARKE M.D., MICHELLE J. $120,609 DAHLEN, DENNIS E. $127,530 DIASIO M.D., ROBERT B. $102,628 DIDEHBAN, ROSHANAK $38,556 DIETER, HEIDI L. $15,388 DOWDY M.D., SEAN C. $60,388 FARRUGIA M.D., GIANRICO $501,999 FONSECA M.D., RAFAEL $111,719 FRANCIS, JAMES R. $48,724 FRANK M.D., IGOR $55,848 GALANIS M.D., EVANTHIA $61,872 GAZELKA M.D., HALENA M. $31,799 GERTZ M.D., MORIE A. $82,949 GORES M.D., GREGORY J. $196,939 GORMAN, PAUL A. $107,872 GOSTOUT M.D., BOBBIE S. $349,763 GRAY M.D., RICHARD J. $242,622 GREENE M.D., EDDIE L. $28,491 HADAWAY, CHERYL J. $79,468 HAEFLINGER, RICKY J. $26,220 HARPER JR., M.D., CHARLES M. $255,639 HAYES M.D., SHARONNE N. $77,118 HEBL M.D., JAMES R. $119,791 HOFFMAN III, HARRY N. $130,201 HORLOCKER M.D., TERESE T. $60,829 HUBERT, SHERRY L. $5,318 KENDRICK M.D., MICHAEL L. $88,590 KHAN M.D., AMIR R. $63,627 KHAN, RITA G. $20,750 KRAHN M.D., LOIS E. $43,748 KRAUSS M.D., WILLIAM E. $242,338 LANZINO M.D., GIUSEPPE $180,914 LEIBOVICH M.D., BRADLEY C. $80,989 LOFTUS M.D., CONOR G. $70,402 LUCCHINETTI M.D., CLAUDIA F. $36,598 LUETMER M.D., PATRICK H. $105,489 MARSH M.D., W. RICHARD $220,919 MCLAUGHLIN M.D., SARAH A. $36,681 MENKOSKY, PAULA E. $131,599 MEYER M.D., FREDRIC B. $223,653 MORICE M.D., WILLIAM G. $76,931 MURPHY, JOSHUA B. $205,357 NARR M.D., BRADLY J. $65,373 NORBY, SUSAN M. $13,028 OKUNO M.D., SCOTT H. $63,463 OTLEY M.D., CLARK C. $164,567 PETERS M.D., STEVE G. $64,189 PICHELMANN M.D., MARK A. $180,947 RIHAL M.D., CHARANJIT S. $111,369 SHAH M.D., VIJAY $129,107 THIELEN M.D., KENT R. $242,622 WALD M.D., JOHN T. $102,689 WARNER M.D., MARK A. $59,908 WHITED M.D., BRIAN L. $54,614 WILLIAMS M.D., AMY W. $133,003 WILLIAMSON, MARY J. $149,659 ZORN, CHRISTINA K. $90,970 UNDER MAYO CLINIC'S ROYALTY SHARING POLICY, INVENTORS, INCLUDING LISTED PERSONS, ARE ENTITLED TO SHARE IN A PORTION OF ROYALTIES RECEIVED BY MAYO INCLUDING INSTANCES WHERE SUCH ROYALTIES ARE IN THE FORM OF EQUITY-BASED INSTRUMENTS SUCH AS STOCK, WARRANTS, OR PARTNERSHIP INTERESTS. THE FOLLOWING INDIVIDUALS PARTICIPATED IN AN EQUITY-BASED COMPENSATION ARRANGEMENT: CAMILLERI M.D., MICHAEL DOWDY M.D., SEAN C. FARRUGIA M.D., GIANRICO MEYER M.D., FREDRIC B. RIHAL M.D., CHARANJIT S. PART II: COMPENSATION PAID TO BOARD MEMBERS IS PRIMARILY FOR PROFESSIONAL RESPONSIBILITIES AS PHYSICIANS, ADMINISTRATORS, OR EMPLOYEES OF THE ORGANIZATION.

Schedule J (Form 990) 2021

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Schedule K
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information on Tax-Exempt Bonds

Complete if the organization answered "Yes" to Form 990, Part Ⅵ, line 24a. Provide descriptions,
explanations, and any additional information in Part Ⅵ.
SchKMediumBullet

Attach to Form 990.
SchKMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
MAYO CLINIC

Employer identification number
41-6011702

Part Ⅰ

Bond Issues

(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	(g) Defeased		(h) On behalf of issuer		(i) Pool financing
(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	Yes	No	Yes	No	Yes	No
A	CITY OF ROCHESTER MINNESOTA	41-6005494	771902FE8	04-10-2008	330,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES & REFUND 1998 BONDS		X		X		X
B	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GA5	05-05-2011	293,208,150	REFUND 1992 AND 2001 BONDS		X		X		X
C	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	04-04-2012	192,662,250	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
D	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GW7	05-08-2014	120,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GB3	12-31-2015	494,267	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	12-31-2015	44,266,950	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GY3	05-03-2016	75,000,000	REFUND 2006 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HE6	10-13-2016	293,825,280	REFUND 2000 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HF3	10-15-2018	200,152,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	000000000	05-15-2020	130,000,000	REFUND 2008 BONDS		X		X		X

Part Ⅱ

Proceeds

	A		B		C		D
	1 Amount of bonds retired ..................	130,000,000		135,494,267		44,266,950
2 Amount of bonds legally defeased ..............
3 Total proceeds of issue ..................	325,948,187		293,208,150		195,311,300		120,012,445
4 Gross proceeds in reserve funds .............
5 Capitalized interest from proceeds .............	8,864,264				12,134,007		310,855
6 Proceeds in refunding escrows ...............
7 Issuance costs from proceeds ...............	2,230,808		2,088,829		1,523,766		400,343
8 Credit enhancement from proceeds .............
9 Working capital expenditures from proceeds .............
10 Capital expenditures from proceeds .............	87,603,115				181,653,527		119,301,247
11 Other spent proceeds .............	227,250,000		291,119,321		75,000,000		290,000,000
12 Other unspent proceeds .............
13 Year of substantial completion .............	2010		2011		2013		2016
	Yes	No	Yes	No	Yes	No	Yes	No
14 Were the bonds issued as part of a current refunding issue of tax-exempt bonds (or, if issued prior to 2020, a current refunding issue)? ........	X		X			X		X
15 Were the bonds issued as part of an advance refunding issue of taxable bonds (or, if issued prior to 2020, an advance refunding issue)? ........		X		X		X		X
16 Has the final allocation of proceeds been made? ..........	X		X		X		X
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? ..................	X		X		X		X

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50193E

Schedule K (Form 990) 2021

Page 2

Part Ⅲ

Private Business Use

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............		X		X		X
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............		X		X		X
3a Are there any management or service contracts that may result in private business use of bond-financed property? .............		X		X		X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?
c Are there any research agreements that may result in private business use of bond-financed property? .............		X		X	X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property?				X		X
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....	0 %		1.020 %		0.090 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government .........	0.010 %		0.020 %		0.250 %
6 Total of lines 4 and 5 .............	0.010 %		1.040 %		0.340 %
7 Does the bond issue meet the private security or payment test? ...		X		X		X
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............	X			X		X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..	24.000 %
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............	X
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under Regulations sections 1.141-12 and 1.145-2? ........	X		X		X

Part Ⅳ

Arbitrage

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ...		X		X		X		X
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......		X		X		X		X
b Exception to rebate? ........		X		X		X		X
c No rebate due? .........	X		X		X		X
If "Yes" to line 2c, provide in Part Ⅵ the date the rebate computation was performed ......
3 Is the bond issue a variable rate issue? .....		X		X		X	X

Schedule K (Form 990) 2021

Page 3

Part Ⅳ

Arbitrage (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?		X		X		X		X
b Name of provider ..........
c Term of hedge .........
d Was the hedge superintegrated? ......
e Was the hedge terminated? ........
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?		X		X		X		X
b Name of provider ..........
c Term of GIC .........
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........
6 Were any gross proceeds invested beyond an available temporary period?		X		X		X		X
7 Has the organization established written procedures to monitor the requirements of section 148? ...	X		X		X		X

Part Ⅴ

Procedures To Undertake Corrective Action

---------------------------------------------------------------------------------------------------------------	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?	X		X		X		X

Part Ⅵ

Supplemental Information. Provide additional information for responses to questions on Schedule K. (See instructions).

Return Reference	Explanation
DATE REBATE COMPUTATION PERFORMED	ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 03/05/2013 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/05/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 11/15/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/08/2019 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020
SCHEDULE K, PART I, COLUMN (E) AND PART II, LINE 3	THE DIFFERENCE BETWEEN PART I, COLUMN (E) AND PART II, LINE 3 FOR THE BOND ISSUES ARE INVESTMENT EARNINGS OR LOSSES.
SCHEDULE K, PART IV, ARBITRAGE CALCULATIONS FOR 2015 BOND ISSUES	DURING 2015 PROPERTY THAT WAS FINANCED BY PREVIOUSLY ISSUED BONDS WAS SOLD. REMEDIAL ACTION WAS REQUIRED DUE TO THE SALE OF BOND-FINANCED PROPERTY WHICH RESULTED IN AN ALLOCABLE PORTION OF EACH OF THE PREVIOUSLY ISSUED BONDS TO BE TREATED AS HAVING BEEN REISSUED - RESULTING IN THE 2015 BOND ISSUES REFLECTED ON THIS SCHEDULE K. THE TRANSFERRED/SALE PROCEEDS WERE DEEMED TO HAVE BEEN SPENT IMMEDIATELY TO RETIRE THE ALLOCABLE PORTIONS OF THE PREVIOUS BOND ISSUES. THE 2015 TRANSFERRED/SALE PROCEEDS WERE REDIRECTED TO ANOTHER QUALIFYING PROJECT ALREADY COMPLETED RESULTING IN ZERO INVESTMENT EARNINGS FOR PURPOSES OF THE ARBITRAGE CALCULATIONS. SINCE THERE WERE NO INVESTMENT EARNINGS RELATED TO THE PROCEEDS, WE HAVE INDICATED FOR PART IV (ARBITRAGE), LINE 2C THAT NO REBATE WAS DUE AS OF DECEMBER 31, 2020.

Schedule K (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Note: To capture the full content of this document, please select landscape mode (11" x 8.5") when printing.

Schedule K
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information on Tax-Exempt Bonds

Complete if the organization answered "Yes" to Form 990, Part Ⅵ, line 24a. Provide descriptions,
explanations, and any additional information in Part Ⅵ.
SchKMediumBullet

Attach to Form 990.
SchKMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
MAYO CLINIC

Employer identification number
41-6011702

Part Ⅰ

Bond Issues

(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	(g) Defeased		(h) On behalf of issuer		(i) Pool financing
(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	Yes	No	Yes	No	Yes	No
A	CITY OF ROCHESTER MINNESOTA	41-6005494	771902FE8	04-10-2008	330,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES & REFUND 1998 BONDS		X		X		X
B	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GA5	05-05-2011	293,208,150	REFUND 1992 AND 2001 BONDS		X		X		X
C	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	04-04-2012	192,662,250	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
D	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GW7	05-08-2014	120,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GB3	12-31-2015	494,267	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	12-31-2015	44,266,950	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GY3	05-03-2016	75,000,000	REFUND 2006 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HE6	10-13-2016	293,825,280	REFUND 2000 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HF3	10-15-2018	200,152,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	000000000	05-15-2020	130,000,000	REFUND 2008 BONDS		X		X		X

Part Ⅱ

Proceeds

	A		B		C		D
	1 Amount of bonds retired ..................	130,000,000		135,494,267		44,266,950
2 Amount of bonds legally defeased ..............
3 Total proceeds of issue ..................	325,948,187		293,208,150		195,311,300		120,012,445
4 Gross proceeds in reserve funds .............
5 Capitalized interest from proceeds .............	8,864,264				12,134,007		310,855
6 Proceeds in refunding escrows ...............
7 Issuance costs from proceeds ...............	2,230,808		2,088,829		1,523,766		400,343
8 Credit enhancement from proceeds .............
9 Working capital expenditures from proceeds .............
10 Capital expenditures from proceeds .............	87,603,115				181,653,527		119,301,247
11 Other spent proceeds .............	227,250,000		291,119,321		75,000,000		290,000,000
12 Other unspent proceeds .............
13 Year of substantial completion .............	2010		2011		2013		2016
	Yes	No	Yes	No	Yes	No	Yes	No
14 Were the bonds issued as part of a current refunding issue of tax-exempt bonds (or, if issued prior to 2020, a current refunding issue)? ........	X		X			X		X
15 Were the bonds issued as part of an advance refunding issue of taxable bonds (or, if issued prior to 2020, an advance refunding issue)? ........		X		X		X		X
16 Has the final allocation of proceeds been made? ..........	X		X		X		X
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? ..................	X		X		X		X

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50193E

Schedule K (Form 990) 2021

Page 2

Part Ⅲ

Private Business Use

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............		X		X		X
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............		X		X		X
3a Are there any management or service contracts that may result in private business use of bond-financed property? .............		X		X		X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?
c Are there any research agreements that may result in private business use of bond-financed property? .............		X		X	X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property?				X		X
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....	0 %		1.020 %		0.090 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government .........	0.010 %		0.020 %		0.250 %
6 Total of lines 4 and 5 .............	0.010 %		1.040 %		0.340 %
7 Does the bond issue meet the private security or payment test? ...		X		X		X
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............	X			X		X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..	24.000 %
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............	X
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under Regulations sections 1.141-12 and 1.145-2? ........	X		X		X

Part Ⅳ

Arbitrage

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ...		X		X		X		X
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......		X		X		X		X
b Exception to rebate? ........		X		X		X		X
c No rebate due? .........	X		X		X		X
If "Yes" to line 2c, provide in Part Ⅵ the date the rebate computation was performed ......
3 Is the bond issue a variable rate issue? .....		X		X		X	X

Schedule K (Form 990) 2021

Page 3

Part Ⅳ

Arbitrage (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?		X		X		X		X
b Name of provider ..........
c Term of hedge .........
d Was the hedge superintegrated? ......
e Was the hedge terminated? ........
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?		X		X		X		X
b Name of provider ..........
c Term of GIC .........
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........
6 Were any gross proceeds invested beyond an available temporary period?		X		X		X		X
7 Has the organization established written procedures to monitor the requirements of section 148? ...	X		X		X		X

Part Ⅴ

Procedures To Undertake Corrective Action

---------------------------------------------------------------------------------------------------------------	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?	X		X		X		X

Part Ⅵ

Supplemental Information. Provide additional information for responses to questions on Schedule K. (See instructions).

Return Reference	Explanation
DATE REBATE COMPUTATION PERFORMED	ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 03/05/2013 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/05/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 11/15/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/08/2019 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020
SCHEDULE K, PART I, COLUMN (E) AND PART II, LINE 3	THE DIFFERENCE BETWEEN PART I, COLUMN (E) AND PART II, LINE 3 FOR THE BOND ISSUES ARE INVESTMENT EARNINGS OR LOSSES.
SCHEDULE K, PART IV, ARBITRAGE CALCULATIONS FOR 2015 BOND ISSUES	DURING 2015 PROPERTY THAT WAS FINANCED BY PREVIOUSLY ISSUED BONDS WAS SOLD. REMEDIAL ACTION WAS REQUIRED DUE TO THE SALE OF BOND-FINANCED PROPERTY WHICH RESULTED IN AN ALLOCABLE PORTION OF EACH OF THE PREVIOUSLY ISSUED BONDS TO BE TREATED AS HAVING BEEN REISSUED - RESULTING IN THE 2015 BOND ISSUES REFLECTED ON THIS SCHEDULE K. THE TRANSFERRED/SALE PROCEEDS WERE DEEMED TO HAVE BEEN SPENT IMMEDIATELY TO RETIRE THE ALLOCABLE PORTIONS OF THE PREVIOUS BOND ISSUES. THE 2015 TRANSFERRED/SALE PROCEEDS WERE REDIRECTED TO ANOTHER QUALIFYING PROJECT ALREADY COMPLETED RESULTING IN ZERO INVESTMENT EARNINGS FOR PURPOSES OF THE ARBITRAGE CALCULATIONS. SINCE THERE WERE NO INVESTMENT EARNINGS RELATED TO THE PROCEEDS, WE HAVE INDICATED FOR PART IV (ARBITRAGE), LINE 2C THAT NO REBATE WAS DUE AS OF DECEMBER 31, 2020.

Schedule K (Form 990) 2021

Additional Data

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Schedule K
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information on Tax-Exempt Bonds

Complete if the organization answered "Yes" to Form 990, Part Ⅵ, line 24a. Provide descriptions,
explanations, and any additional information in Part Ⅵ.
SchKMediumBullet

Attach to Form 990.
SchKMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
MAYO CLINIC

Employer identification number
41-6011702

Part Ⅰ

Bond Issues

(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	(g) Defeased		(h) On behalf of issuer		(i) Pool financing
(a) Issuer name		(b) Issuer EIN	(c) CUSIP #	(d) Date issued	(e) Issue price	(f) Description of purpose	Yes	No	Yes	No	Yes	No
A	CITY OF ROCHESTER MINNESOTA	41-6005494	771902FE8	04-10-2008	330,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES & REFUND 1998 BONDS		X		X		X
B	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GA5	05-05-2011	293,208,150	REFUND 1992 AND 2001 BONDS		X		X		X
C	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	04-04-2012	192,662,250	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
D	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GW7	05-08-2014	120,000,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GB3	12-31-2015	494,267	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GD9	12-31-2015	44,266,950	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902GY3	05-03-2016	75,000,000	REFUND 2006 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HE6	10-13-2016	293,825,280	REFUND 2000 BONDS		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	771902HF3	10-15-2018	200,152,000	CONSTRUCTION OF HEALTH CARE FACILITIES		X		X		X
	CITY OF ROCHESTER MINNESOTA	41-6005494	000000000	05-15-2020	130,000,000	REFUND 2008 BONDS		X		X		X

Part Ⅱ

Proceeds

	A		B		C		D
	1 Amount of bonds retired ..................	130,000,000		135,494,267		44,266,950
2 Amount of bonds legally defeased ..............
3 Total proceeds of issue ..................	325,948,187		293,208,150		195,311,300		120,012,445
4 Gross proceeds in reserve funds .............
5 Capitalized interest from proceeds .............	8,864,264				12,134,007		310,855
6 Proceeds in refunding escrows ...............
7 Issuance costs from proceeds ...............	2,230,808		2,088,829		1,523,766		400,343
8 Credit enhancement from proceeds .............
9 Working capital expenditures from proceeds .............
10 Capital expenditures from proceeds .............	87,603,115				181,653,527		119,301,247
11 Other spent proceeds .............	227,250,000		291,119,321		75,000,000		290,000,000
12 Other unspent proceeds .............
13 Year of substantial completion .............	2010		2011		2013		2016
	Yes	No	Yes	No	Yes	No	Yes	No
14 Were the bonds issued as part of a current refunding issue of tax-exempt bonds (or, if issued prior to 2020, a current refunding issue)? ........	X		X			X		X
15 Were the bonds issued as part of an advance refunding issue of taxable bonds (or, if issued prior to 2020, an advance refunding issue)? ........		X		X		X		X
16 Has the final allocation of proceeds been made? ..........	X		X		X		X
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? ..................	X		X		X		X

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50193E

Schedule K (Form 990) 2021

Page 2

Part Ⅲ

Private Business Use

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............		X		X		X
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............		X		X		X
3a Are there any management or service contracts that may result in private business use of bond-financed property? .............		X		X		X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?
c Are there any research agreements that may result in private business use of bond-financed property? .............		X		X	X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property?				X		X
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....	0 %		1.020 %		0.090 %
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government .........	0.010 %		0.020 %		0.250 %
6 Total of lines 4 and 5 .............	0.010 %		1.040 %		0.340 %
7 Does the bond issue meet the private security or payment test? ...		X		X		X
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............	X			X		X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..	24.000 %
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............	X
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under Regulations sections 1.141-12 and 1.145-2? ........	X		X		X

Part Ⅳ

Arbitrage

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ...		X		X		X		X
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? .......		X		X		X		X
b Exception to rebate? ........		X		X		X		X
c No rebate due? .........	X		X		X		X
If "Yes" to line 2c, provide in Part Ⅵ the date the rebate computation was performed ......
3 Is the bond issue a variable rate issue? .....		X		X		X	X

Schedule K (Form 990) 2021

Page 3

Part Ⅳ

Arbitrage (Continued)

	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?		X		X		X		X
b Name of provider ..........
c Term of hedge .........
d Was the hedge superintegrated? ......
e Was the hedge terminated? ........
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?		X		X		X		X
b Name of provider ..........
c Term of GIC .........
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........
6 Were any gross proceeds invested beyond an available temporary period?		X		X		X		X
7 Has the organization established written procedures to monitor the requirements of section 148? ...	X		X		X		X

Part Ⅴ

Procedures To Undertake Corrective Action

---------------------------------------------------------------------------------------------------------------	A		B		C		D
	Yes	No	Yes	No	Yes	No	Yes	No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations?	X		X		X		X

Part Ⅵ

Supplemental Information. Provide additional information for responses to questions on Schedule K. (See instructions).

Return Reference	Explanation
DATE REBATE COMPUTATION PERFORMED	ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 03/05/2013 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/05/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 11/15/2016 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 05/08/2019 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020 ISSUER NAME: CITY OF ROCHESTER, MINNESOTA DATE THE REBATE COMPUTATION WAS PERFORMED: 12/31/2020
SCHEDULE K, PART I, COLUMN (E) AND PART II, LINE 3	THE DIFFERENCE BETWEEN PART I, COLUMN (E) AND PART II, LINE 3 FOR THE BOND ISSUES ARE INVESTMENT EARNINGS OR LOSSES.
SCHEDULE K, PART IV, ARBITRAGE CALCULATIONS FOR 2015 BOND ISSUES	DURING 2015 PROPERTY THAT WAS FINANCED BY PREVIOUSLY ISSUED BONDS WAS SOLD. REMEDIAL ACTION WAS REQUIRED DUE TO THE SALE OF BOND-FINANCED PROPERTY WHICH RESULTED IN AN ALLOCABLE PORTION OF EACH OF THE PREVIOUSLY ISSUED BONDS TO BE TREATED AS HAVING BEEN REISSUED - RESULTING IN THE 2015 BOND ISSUES REFLECTED ON THIS SCHEDULE K. THE TRANSFERRED/SALE PROCEEDS WERE DEEMED TO HAVE BEEN SPENT IMMEDIATELY TO RETIRE THE ALLOCABLE PORTIONS OF THE PREVIOUS BOND ISSUES. THE 2015 TRANSFERRED/SALE PROCEEDS WERE REDIRECTED TO ANOTHER QUALIFYING PROJECT ALREADY COMPLETED RESULTING IN ZERO INVESTMENT EARNINGS FOR PURPOSES OF THE ARBITRAGE CALCULATIONS. SINCE THERE WERE NO INVESTMENT EARNINGS RELATED TO THE PROCEEDS, WE HAVE INDICATED FOR PART IV (ARBITRAGE), LINE 2C THAT NO REBATE WAS DUE AS OF DECEMBER 31, 2020.

Schedule K (Form 990) 2021

Additional Data

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Schedule L
(Form 990)

Department of the Treasury
Internal Revenue Service

Transactions with Interested Persons

Complete if the organization answered "Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c, or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet

Attach to Form 990 or Form 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Excess Benefit Transactions (section 501(c)(3), section 501(c)(4), and section 501(c)(29) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.

1(a) Name of disqualified person	(c) Description of transaction	(d) Corrected?
1(a) Name of disqualified person	(c) Description of transaction	Yes	No

Enter the amount of tax incurred by the organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image

Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ........ Bullet Image

Part II

Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22

(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	(d) Loan to or from the organization?		(e) Original principal amount	(f) Balance due	(g) In default?		(h) Approved by board or committee?		(i) Written agreement?
(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	To	From	(e) Original principal amount	(f) Balance due	Yes	No	Yes	No	Yes	No






Total ............... $

Part III

Grants or Assistance Benefiting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of assistance	(d) Type of assistance
(1)	MERIT SCHOLARSHIP	30,000	SCHOLARSHIP

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50056A

Schedule L (Form 990) 2021

Page 2

Part IV

Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of transaction	(d) Description of transaction	(e) Sharing of organization's revenues?
(a) Name of interested person		(c) Amount of transaction	(d) Description of transaction	Yes	No
(1) EMANUEL ELIZABETH M	FAMILY MEMBER OF FORMER OFFICER NORBY, SUSAN M.	77,720	EMPLOYMENT		No
(2) GORMAN ELLEN K	FAMILY MEMBER OF TREASURER/ASST TREASURER GORMAN, PAUL A.	15,718	EMPLOYMENT		No
(3) KENDRICK CONNER D	FAMILY MEMBER OF PHYSICIAN KENDRICK M.D., MICHAEL L.	44,502	EMPLOYMENT		No
(4) LAMER MD TIM J	FAMILY MEMBER OF PHYSICIAN GAZELKA M.D., HALENA M.	585,122	EMPLOYMENT		No
(5) LARSON MD MARK V	FAMILY MEMBER OF TRUSTEE WILLIAMS M.D., AMY W.	742,002	EMPLOYMENT		No
(6) LUETMER MD MARIANNE T	FAMILY MEMBER OF FORMER KEY EMPLOYEE LUETMER M.D., PATRICK H.	101,237	EMPLOYMENT		No
(7) MEISSNER MD IRENE	FAMILY MEMBER OF FORMER KEY EMPLOYEE MEYER M.D., FREDRIC B.	349,781	EMPLOYMENT		No
(8) MIDTHUN MD DAVID E	FAMILY MEMBER OF TRUSTEE WILLIAMS M.D., AMY W.	628,346	EMPLOYMENT		No
(9) NEAL MD LONZETTA	FAMILY MEMBER OF TRUSTEE GREENE M.D., EDDIE L.	193,624	EMPLOYMENT		No
(10) PETERS MD MARGOT S	FAMILY MEMBER OF PHYSICIAN PETERS M.D., STEVE G.	333,687	EMPLOYMENT		No
(11) SAITO LOFTUS MD YURI A	FAMILY MEMBER OF FORMER KEY EMPLOYEE LOFTUS M.D., CONOR G.	379,081	EMPLOYMENT		No
(12) UHLENKAMP NOAH B	FAMILY MEMBER OF FORMER OFFICER NORBY, SUSAN M.	39,034	EMPLOYMENT		No
(13) WALD MICHELLE K	FAMILY MEMBER OF PHYSICIAN WALD M.D., JOHN T.	69,494	EMPLOYMENT		No
(14) WARNER MD LINDSAY L	FAMILY MEMBER OF FORMER KEY EMPLOYEE WARNER M.D., MARK A.	396,303	EMPLOYMENT		No
(15) WARNER MD MARY E	FAMILY MEMBER OF FORMER KEY EMPLOYEE WARNER M.D., MARK A.	334,325	EMPLOYMENT		No
(16) WARNER MD MATTHEW A	FAMILY MEMBER OF FORMER KEY EMPLOYEE WARNER M.D., MARK A.	571,386	EMPLOYMENT		No
(17) WARNER MD NAFISSEH S	FAMILY MEMBER OF FORMER KEY EMPLOYEE WARNER M.D., MARK A.	556,950	EMPLOYMENT		No
(18) WARNER MD PAUL A	FAMILY MEMBER OF FORMER KEY EMPLOYEE WARNER M.D., MARK A.	575,804	EMPLOYMENT		No
(19) WIEPERT DANIELA A	FAMILY MEMBER OF TRUSTEE LUCCHINETTI M.D., CLAUDIA F.	36,991	EMPLOYMENT		No
(20) WILLIAMSON MD ERIC E	FAMILY MEMBER OF VICE CHAIR/CAO-MCHS WILLIAMSON, MARY J.	838,029	EMPLOYMENT		No
(21) RELATED TO SUBSTANTIAL CONTRIBUTOR	CONTROLLED ENTITY OF SUBSTANTIAL CONTRIBUTOR	132,990	BUSINESS TRANSACTIONS		No

Part V

Supplemental Information
Provide additional information for responses to questions on Schedule L (see instructions).

Return Reference	Explanation

Schedule L (Form 990) 2021

Additional Data

Software ID:
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SCHEDULE M
(Form 990)

Department of the Treasury

Internal Revenue Service

Noncash Contributions

Complete if the organizations answered "Yes" on Form 990, Part IV, lines 29 or 30.
Right pointing arrow large image

Attach to Form 990.
Right pointing arrow large image

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Types of Property

	(a) Check if applicable	(b) Number of contributions or items contributed	(c) Noncash contribution amounts reported on Form 990, Part VIII, line 1g	(d) Method of determining noncash contribution amounts
1 Art—Works of art ....	X	4		EXPERTS
2 Art—Historical treasures .
3 Art—Fractional interests ..
4 Books and publications ..
5 Clothing and household goods .......	X		0	EXPERTS
6 Cars and other vehicles ..
7 Boats and planes ....
8 Intellectual property ...
9 Securities—Publicly traded .	X	372	47,986,234	MEAN MARKET VALUE
10 Securities—Closely held stock .	X	1	53,951	EXPERTS
11 Securities—Partnership, LLC, or trust interests ....	X	2	64,567,326	EXPERTS
12 Securities—Miscellaneous ..	X	3	13,003	EXPERTS
13 Qualified conservation contribution—Historic structures .....
14 Qualified conservation contribution—Other ...
15 Real estate—Residential .	X	4	3,402,880	EXPERTS
16 Real estate—Commercial ..	X	2	1,044,160	EXPERTS
17 Real estate—Other ...
18 Collectibles .....	X	1	0	EXPERTS
19 Food inventory ...	X	1	0	EXPERTS
20 Drugs and medical supplies .	X	1	0	EXPERTS
21 Taxidermy ......
22 Historical artifacts ....
23 Scientific specimens ..
24 Archeological artifacts ...
25 Other ( EQUIPMENT )	X	4	187,816	EXPERTS
26 Other ( OTHER MISC )	X	2	0	EXPERTS
27 Other ( )
28 Other ( )

Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part IV, Donee Acknowledgement

Yes

30a

During the year, did the organization receive by contribution any property reported in Part I, lines 1 through 28, that it must hold for at least three years from the date of the initial contribution, and which isn't required to be used for exempt purposes for the entire holding period? ...................

30a

If "Yes," describe the arrangement in Part II.

Does the organization have a gift acceptance policy that requires the review of any nonstandard contributions?

Yes

32a

Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash

contributions? ..........................

32a

Yes

If "Yes," describe in Part II.

If the organization didn't report an amount in column (c) for a type of property for which column (a) is checked,

describe in Part II.

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 51227J

Schedule M (Form 990) (2021)

Page 2

Part IISupplemental Information. Provide the information required by Part I, lines 30b, 32b, and 33, and whether the organization is reporting in Part I, column (b), the number of contributions, the number of items received, or a combination of both. Also complete this part for any additional information.

Return Reference	Explanation
PART I, COLUMN (B):	FOR PURPOSES OF SCHEDULE M, MAYO CLINIC IS REPORTING THE NUMBER OF CONTRIBUTIONS IN COLUMN (B).
PART I, LINE 32B:	MAYO CLINIC (MAYO) UTILIZES SEVERAL THIRD PARTIES TO SELL NON-CASH CONTRIBUTIONS. FOR REAL ESTATE GIFTS, MAYO CONTRACTS WITH REALTORS AND BROKERS; FOR STOCK AND SECURITY GIFTS MAYO UTILIZES SEVERAL DIFFERENT BROKERS AND BROKERAGE FIRMS; FOR TANGIBLE PERSONAL PROPERTY, MAYO USES VARIOUS AUCTION OUTLETS DEPENDING ON THE VALUE (I.E. BONHAMS, CHRISTIE'S, SOTHEBY'S, ETC.). THESE ARRANGEMENTS ARE ALL FEE AND COMMISSION-BASED.
PART I, LINE 33:	MAYO CLINIC RECEIVED CONTRIBUTIONS OF WORKS OF ART DURING THE YEAR WHERE NO REVENUE WAS RECORDED. AS PERMITTED UNDER GENERALLY ACCEPTED ACCOUNTING PRINCIPLES (SFAS 116), MAYO CLINIC DID NOT RECOGNIZE REVENUE OR CAPITALIZE THE WORKS OF ART. MAYO CLINIC RECEIVED IN-KIND GIFTS (BOOKS/PUBLICATIONS, CLOTHING/HOUSEHOLD GOODS, SUPPLIES, ETC.) THROUGHOUT THE YEAR WHERE NO REVENUE WAS RECORDED AND NO DESCRIPTIVE RECEIPTS WERE ISSUED. REVENUE IS RECOGNIZED ON GIFTS IN-KIND WHEN THE FAIR MARKET VALUE MEETS CAPITALIZATION THRESHOLDS OR WHEN TANGIBLE PERSONAL PROPERTY IS SOLD.

Schedule M (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE O
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet

Attach to Form 990 or 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Return Reference	Explanation
FORM 990 LINE H	MAYO CLINIC IS INCLUDED IN A GROUP EXEMPTION. THE GROUP EXEMPTION COVERS MAYO CLINIC (THE CENTRAL ORGANIZATION) AND MAYO CLINIC'S AFFILIATED SUBSIDIARIES (THE SUBORDINATE ORGANIZATIONS). FOR 2021, A GROUP RETURN (MAYO CLINIC GROUP RETURN - EIN: 38-3952644) WAS FILED THAT INCLUDED SEVENTEEN OF MAYO CLINIC'S SUBORDINATE ORGANIZATIONS. IN ACCORDANCE WITH REG. 1.6033-2(D)(5), WITH RESPECT TO THE CENTRAL ORGANIZATION, MAYO CLINIC HAS REPORTED THE INFORMATION REQUIRED BY REG. 1.6033-2(A)(2)(II)(F), (G) AND (H) ON ITS FORM 990 FOR THE 2021 TAX YEAR. THIS IS IN LIEU OF CONSOLIDATING SUCH INFORMATION WITH ITS SUBORDINATE ORGANIZATIONS AND REPORTING SUCH INFORMATION ON THE 2021 MAYO CLINIC GROUP RETURN.
FORM 990, PART VI, SECTION A, LINE 1A	BETWEEN MEETINGS OF MAYO CLINIC'S BOARD OF TRUSTEES, MAYO CLINIC'S BYLAWS DELEGATE TO THE MAYO CLINIC BOARD OF GOVERNORS, AN EXECUTIVE COMMITTEE OF THE BOARD OF TRUSTEES, BROAD AUTHORITY TO EXERCISE THE POWERS OF THE BOARD OF TRUSTEES WITHIN CERTAIN LIMITATIONS OF TIME AND TOPIC.
FORM 990, PART VI, SECTION A, LINE 2	THE FOLLOWING INDIVIDUAL(S) IS/ARE EMPLOYED BY A RELATED ORGANIZATION: GRAY M.D., RICHARD J., DAHLEN, DENNIS E., WILLIAMS M.D., AMY W., ZORN, CHRISTINA K., THIELEN M.D., KENT R., NORBY, MARK L., MURPHY, JOSHUA B., HUBERT, SHERRY L., GOSTOUT M.D., BOBBIE S., GORMAN, PAUL A., FRANCIS, JAMES R., FARRUGIA M.D., GIANRICO, BROWN, WILLIAM A., BOLTON, JEFFREY W., RESULTING IN A BUSINESS RELATIONSHIP WITH THE FOLLOWING INDIVIDUAL(S) WHO IS/ARE ASSOCIATED WITH THE RELATED ORGANIZATION AS AN OFFICER, DIRECTOR, OR TRUSTEE: ZORN, CHRISTINA K., MENKOSKY, PAULA E., OTLEY M.D., CLARK C., DAHLEN, DENNIS E., MURPHY, JOSHUA B., HUBERT, SHERRY L., GORMAN, PAUL A., FRANCIS, JAMES R., BROWN, WILLIAM A., THE FOLLOWING INDIVIDUAL(S) IS/ARE EMPLOYED BY A RELATED ORGANIZATION: FONSECA M.D., RAFAEL, MENKOSKY, PAULA E., KRAHN M.D., LOIS E., RESULTING IN A BUSINESS RELATIONSHIP WITH THE FOLLOWING INDIVIDUAL(S) WHO IS/ARE ASSOCIATED WITH THE RELATED ORGANIZATION AS AN OFFICER, DIRECTOR, OR TRUSTEE: FONSECA M.D., RAFAEL, MENKOSKY, PAULA E., KRAHN M.D., LOIS E., GRAY M.D., RICHARD J., THE FOLLOWING INDIVIDUAL(S) IS/ARE EMPLOYED BY A RELATED ORGANIZATION: MCLAUGHLIN M.D., SARAH A., ZORN, CHRISTINA K., RESULTING IN A BUSINESS RELATIONSHIP WITH THE FOLLOWING INDIVIDUAL(S) WHO IS/ARE ASSOCIATED WITH THE RELATED ORGANIZATION AS AN OFFICER, DIRECTOR, OR TRUSTEE: MCLAUGHLIN M.D., SARAH A., ZORN, CHRISTINA K., THIELEN M.D., KENT R., ********************** DAHLEN, DENNIS E., MURPHY, JOSHUA B., HUBERT, SHERRY L., HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF MAYO HOLDING COMPANY, A RELATED TAXABLE ENTITY. DAHLEN, DENNIS E., GORMAN, PAUL A., HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF MAYO INSURANCE COMPANY, LTD, A RELATED TAXABLE ENTITY. WILLIAMSON, MARY J., BOLTON, JEFFREY W., HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF RESOUNDANT, INC, A RELATED TAXABLE ENTITY. HAEFLINGER, RICKY J., GORMAN, PAUL A., HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF LATIGO PETROLEUM, A RELATED TAXABLE ENTITY. BAKER JR., DOUGLAS M. SALAZAR, KENNETH L. HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF TARGET CORPORATION.
FORM 990, PART VI, SECTION A, LINE 3	MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH AND OTHER RELATED COMPANIES PROVIDE MANAGEMENT SERVICES TO THE ENTIRE SYSTEM OF ENTITIES WHICH WOULD INCLUDE THE FILING ORGANIZATION. SINCE THE ENTITIES ARE RELATED ORGANIZATIONS, COMPENSATION FOR THE OFFICERS, DIRECTORS, KEY EMPLOYEES, AND HIGHEST COMPENSATED EMPLOYEES HAS BEEN DISCLOSED IN PART VII AND SCHEDULE J AS REQUIRED.
FORM 990, PART VI, SECTION B, LINE 11B	THE FORM 990 IS PREPARED BY MAYO CORPORATE TAX. THE TAX RETURN GOES THROUGH TWO LEVELS OF REVIEW WITHIN THE CORPORATE TAX UNIT AND IS REVIEWED BY THE TAX DIRECTOR. IT IS THEN REVIEWED BY THE DIVISION CHAIR-ACCOUNTING, CHAIR-FINANCIAL AND ACCOUNTING SERVICES, CHAIR-REVENUE CYCLE, CHIEF INVESTMENT OFFICER, CHIEF FINANCIAL OFFICER AND CHIEF LEGAL OFFICER. A COPY OF THE FORM 990 IS THEN PROVIDED TO EACH MEMBER OF MAYO CLINIC'S GOVERNING BODY VIA US MAIL, E-MAIL, OR DISTRIBUTION AT A BOARD MEETING. ALL QUESTIONS ARE ADDRESSED PRIOR TO FILING THE FORM 990.
FORM 990, PART VI, SECTION B, LINE 12C	MAYO CLINIC AND ITS AFFILIATES HAVE A COMPREHENSIVE CONFLICT OF INTEREST POLICY APPLICABLE TO ALL OF THE AFFILIATED ENTITIES AND TO ALL DIRECTORS, OFFICERS, AND EMPLOYEES OF THOSE ENTITIES. ALL CURRENT AND FORMER OFFICERS, DIRECTORS, TRUSTEES, KEY EMPLOYEES AND HIGHEST COMPENSATED EMPLOYEES WHO WE ANTICIPATE WILL BE LISTED ON A FORM 990 ARE ASKED TO COMPLETE AN "ANNUAL TAX AND COMPLIANCE DISCLOSURE" FORM. THIS INFORMATION IS REVIEWED BY BOTH THE CORPORATE TAX DEPARTMENT AND THE OFFICE OF CONFLICT OF INTEREST REVIEW. ALL DISCLOSURES OF CURRENT OR PROPOSED ACTIVITY THAT REQUIRE ACTION UNDER THE POLICY ARE THE SUBJECT OF ONGOING REVIEW AND ACTION THROUGH THE OFFICE OF CONFLICT OF INTEREST REVIEW AND THE CONFLICT OF INTEREST REVIEW BOARD. INVOLVED INDIVIDUALS ARE INFORMED OF ALL REQUIRED ACTION. MANY TYPES OF RELATIONSHIPS THAT COULD CREATE CONFLICTS OF INTEREST ARE PROHIBITED. OTHER TYPES OF RELATIONSHIPS ARE PERMITTED SUBJECT TO COMPLIANCE WITH THE MANAGEMENT PLAN ESTABLISHED BY THE CONFLICT OF INTEREST REVIEW BOARD. A COMMON MANAGEMENT STRATEGY FOR PERMITTED ACTIVITIES IS TO REQUIRE BILATERAL RECUSAL AND APPROPRIATE DOCUMENTATION IN THE MINUTES OF MAYO CLINIC (AND/OR AFFILIATE) AND THE OUTSIDE ENTITY. ADDITIONAL CONFLICT OF INTEREST POLICIES AND PROCEDURES EXIST FOR CERTAIN ENTITIES CONCERNING RESEARCH CONTRACTS AND OTHER TYPES OF POTENTIAL CONFLICTS. THIS POLICY APPLIES TO THE ORGANIZATION'S DISREGARDED ENTITIES.
FORM 990, PART VI, SECTION B, LINE 15B	MAYO CLINIC AND ITS AFFILIATES HAVE A COORDINATED PROCESS FOR REVIEWING AND APPROVING COMPENSATION AND BENEFITS FOR EXECUTIVE LEADERSHIP, CONSULTING STAFF AND SENIOR ADMINISTRATIVE LEADERSHIP, ALONG WITH ALLIED HEALTH STAFF. IN ADDITION TO ANY REVIEW AND APPROVAL THAT MAY TAKE PLACE AT THE LOCAL ENTITY OR REGIONAL LEVEL, THE FOLLOWING INDEPENDENT APPROVAL PROCESS OCCURS ANNUALLY PRIOR TO IMPLEMENTATION OF THE RESPECTIVE COMPENSATION INCREASE. THE COMPENSATION AND BENEFITS OF THE CEO AND SEVERAL OTHER OFFICERS AND KEY EMPLOYEES OF MAYO CLINIC AND MAYO CLINIC GROUP WERE REVIEWED AND APPROVED BY THE PROCESS DESCRIBED BELOW. THE COMPENSATION AND BENEFITS OF EXECUTIVE LEADERSHIP, CONSULTING STAFF AND SENIOR ADMINISTRATIVE LEADERSHIP FOR ALL CAMPUSES, INCLUDING THE MAYO CLINIC HEALTH SYSTEM LOCATIONS, ARE REVIEWED AND APPROVED BY THE MAYO CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING COMMITTEE. THE MAYO CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING COMMITTEE IS COMPRISED OF NINE OF THE EXTERNAL INDEPENDENT MEMBERS OF THE MAYO CLINIC BOARD OF TRUSTEES. THIS GROUP REVIEWS AND APPROVES THE COMPENSATION AND BENEFIT PROGRAMS FOR EXECUTIVE LEADERSHIP, CONSULTING STAFF AND CERTAIN SENIOR ADMINISTRATIVE LEADERSHIP FROM ALL CAMPUSES (INCLUDING ALL PERSONS BELIEVED TO BE DISQUALIFIED PERSONS). THIS PROCESS ESTABLISHES ACCEPTABLE RANGES FOR VARIOUS POSITIONS, LEVELS, AND SPECIALTIES. THE COMMITTEE USES COMPARABILITY DATA (INCLUDING THIRD-PARTY BENCHMARKING SURVEYS) IN ITS REVIEW AND DOCUMENTS DECISIONS IN ITS REVIEW AND DOCUMENTS DECISIONS IN ITS MINUTES. IN ADDITION, THE MAYO CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING COMMITTEE DIRECTLY RETAINS AN INDEPENDENT THIRD-PARTY COMPENSATION CONSULTANT TO PROVIDE RELEVANT, CONTEMPORANEOUS BENCHMARK INFORMATION FOR A SMALL GROUP OF EXECUTIVE LEADERSHIP AND SENIOR PHYSICIAN POSITIONS (INCLUDING THE CEO) FOR WHICH AN INDIVIDUALIZED REVIEW AND RECOMMENDATION IS MADE.
FORM 990, PART VI, SECTION C, LINE 19	MAYO CLINIC'S ARTICLES OF INCORPORATION ARE AVAILABLE THROUGH THE SECRETARY OF STATE'S OFFICE OR UPON REQUEST FROM MAYO CLINIC. BYLAWS AND OTHER GOVERNANCE DOCUMENTS ARE AVAILABLE UPON REQUEST FOR PURPOSES THAT MAYO CLINIC DEEMS APPROPRIATE. THE CONFLICT OF INTEREST POLICY IS AVAILABLE ON MAYO CLINIC'S WEBSITE OR UPON REQUEST. MAYO CLINIC'S CONSOLIDATED FINANCIAL STATEMENTS AND FEDERAL FORM 990 ARE AVAILABLE UPON REQUEST.
FORM 990, PART IX, LINE 11G	I/C PURCHASED SERVICES: PROGRAM SERVICE EXPENSES 43,064,165. MANAGEMENT AND GENERAL EXPENSES 788,189,437. FUNDRAISING EXPENSES 1,867,122. TOTAL EXPENSES 833,120,724. OTHER PURCHASED SERVICES: PROGRAM SERVICE EXPENSES 226,924,451. MANAGEMENT AND GENERAL EXPENSES 14,429,153. FUNDRAISING EXPENSES 6,172,485. TOTAL EXPENSES 247,526,089.
FORM 990, PART XI, LINE 9:	PENSION-POST RETIREMENT (PER FASB A 1,421,305,013. FRANKLIN HEATING STATION CONVERSION 50,281,490. DECORAH CONVERSION 379,365. LOSSES ON UNCOLLECTIBLE PLEDGES -28,948,436. REFUNDS OF CONTRIBUTIONS -144,769.
FORM 990, PART XII, LINE 2C, AUDIT PROCESS	THE OVERSIGHT OF THE AUDIT PROCESS OR THE PROCESS FOR SELECTING AN AUDITOR HAS NOT CHANGED.

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 51056K

Schedule O (Form 990) 2021

Additional Data

Software ID:
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- TIN:

SCHEDULE R
(Form 990)

Department of the Treasury
Internal Revenue Service

Related Organizations and Unrelated Partnerships

Complete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBullet

Attach to Form 990.
MediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

MAYO CLINIC

Employer identification number

41-6011702

Part I

Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.

(a) Name, address, and EIN (if applicable) of disregarded entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Total income	(e) End-of-year assets	(f) Direct controlling entity
(1) JOHN E HERMAN HOME AND TREATMENT FACILITY LLC 200 FIRST STREET SW ROCHESTER,MN55905 82-4183345	RESIDENTIAL RECOVERY AND TREATMENT FACILITY	MN	-26,043	6,069,647	MAYO CLINIC
(2) MAYO CLINIC COMMUNITY ACO LLC 200 FIRST STREET SW ROCHESTER,MN55905 83-0610557	ACCOUNTABLE CARE ORGANIZATION	MN	12,651,112	103,424	MAYO CLINIC
(3) MAYO COLLABORATIVE SERVICES LLC 200 FIRST STREET SW ROCHESTER,MN55905 41-1346366	REFERENCE LAB SERVICES	MN	986,156,811	269,357,351	MAYO CLINIC
(4) MC INTERNATIONAL LLC 200 FIRST STREET SW ROCHESTER,MN55905 83-2805059	CONTRACTING SERVICES	MN	-2,486,272	39,736,547	MAYO CLINIC
(5) MC PROPERTY HOLDINGS LLC 200 FIRST STREET SW ROCHESTER,MN55905 84-3454849	REAL ESTATE	MN	0	0	MAYO CLINIC
(6) FRANKLIN HEATING STATION LLC 200 FIRST STREET SW ROCHESTER,MN55905 41-0264830	UTILITY	MN	508,461	57,321,627	MAYO CLINIC
(7) MCHS--DECORAH CLINIC PHYSICIANS LLC 907 MONTGOMERY STREET DECORAH,IA52101 41-1711329	PATIENT CARE - CLINIC	WI	0	8,043,151	MAYO CLINIC
(8) KAHG LLC 200 FIRST STREET SW ROCHESTER,MN55905 20-1276436	REAL ESTATE	AZ	0	92,161	MAYO CLINIC

Part II

Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	(g) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	Yes	No
(1)BLOOMER LAKEVIEW INC 2110 DUNCAN ROAD BLOOMER,WI54724 39-1450617	LOW INCOME HOUSING	WI	501(C)(3)	7	MCHS--NORTHWEST WISCONSIN REGION INC	Yes
(2)CHARTERHOUSE INC 200 FIRST STREET SW ROCHESTER,MN55905 41-1405254	RETIREMENT LIVING CENTER	MN	501(C)(3)	10	MAYO CLINIC	Yes
(3)DESTINATION MEDICAL CENTER EDA 50 SOUTH SIXTH STREET SUITE 1500 MINNEAPOLIS,MN554021498 46-4893585	ECONOMIC DEVELOPMENT	MN	501(C)(3)	12-I	MAYO CLINIC	Yes
(4)MAYO CLINIC AMBULANCE 200 FIRST STREET SW ROCHESTER,MN55905 41-1917516	AMBULANCE SERVICE	MN	501(C)(3)	10	MFMER	Yes
(5)LUTHER LAKESIDE APARTMENTS INC PO BOX 1510 EAU CLAIRE,WI54702 39-1409024	LOW INCOME HOUSING FOR ELDERLY	WI	501(C)(3)	10	MCHS--NORTHWEST WISCONSIN REGION INC	Yes
(6)MAYO CLINIC ARIZONA 13400 EAST SHEA BOULEVARD SCOTTSDALE,AZ85259 86-0800150	HOSPITAL AND CLINIC	AZ	501(C)(3)	3	MAYO CLINIC	Yes
(7)MAYO CLINIC FLORIDA (A NONPROFIT CORPORATION) 4500 SAN PABLO ROAD JACKSONVILLE,FL32224 59-0714831	HOSPITAL	FL	501(C)(3)	3	MAYO CLINIC JACKSONVILLE	Yes
(8)MAYO CLINIC HOSPITAL -- ROCHESTER 200 FIRST STREET SW ROCHESTER,MN55905 41-0944601	HOSPITAL	MN	501(C)(3)	3	MAYO CLINIC	Yes
(9)MAYO CLINIC JACKSONVILLE 4500 SAN PABLO ROAD JACKSONVILLE,FL32224 59-3337028	PATIENT CARE - CLINIC	FL	501(C)(3)	7	MAYO CLINIC	Yes
(10)MAYO CLINIC STIFTUNG 60486 FRANKFURT AM MAIN FRANKFURT GM	FUNDRAISING FOUNDATION	GM			MFMER	Yes
(11)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 200 FIRST STREET SW ROCHESTER,MN55905 41-1506440	CHARITABLE, EDUCATIONAL & SCIENTIFIC ACTIVITIES	MN	501(C)(3)	10	MAYO CLINIC	Yes
(12)MCHS--AUSTIN FOUNDATION 1000 FIRST DRIVE NW AUSTIN,MN55912 30-0107471	FUNDRAISING FOUNDATION	MN	501(C)(3)	12-I	MCHS--SOUTHEAST MINNESOTA REGION	Yes
(13)MCHS--FAIRMONT 800 MEDICAL CENTER DRIVE PO BOX 800 FAIRMONT,MN56031 41-0760836	HOSPITAL AND CLINIC	MN	501(C)(3)	3	MCHS--SOUTHWEST MINNESOTA REGION	Yes
(14)MCHS--FRANCISCAN MEDICAL CENTER INC 700 WEST AVE SOUTH LA CROSSE,WI54601 39-0806374	HOSPITAL AND CLINIC	WI	501(C)(3)	3	MAYO CLINIC	Yes
(15)MCHS--LAKE CITY 500 WEST GRANT STREET LAKE CITY,MN55041 41-1906820	HOSPITAL	MN	501(C)(3)	3	MAYO CLINIC	Yes
(16)MCHS--NORTHWEST WISCONSIN REGION INC 1221 WHIPPLE STREET EAU CLAIRE,WI54703 39-0813418	HOSPITAL	WI	501(C)(3)	3	MAYO CLINIC	Yes
(17)MCHS--SOUTHEAST MINNESOTA REGION 1000 FIRST DRIVE NW AUSTIN,MN55912 41-1404075	HOSPITAL AND CLINIC	MN	501(C)(3)	3	MAYO CLINIC	Yes
(18)MCHS--SOUTHWEST MINNESOTA REGION 1025 MARSH STREET MANKATO,MN56001 41-1236756	HOSPITAL AND CLINIC	MN	501(C)(3)	3	MAYO CLINIC	Yes
(19)MCHS--ST JAMES 1101 MOULTON PARSONS DR PO BOX 460 ST JAMES,MN56081 41-0797368	HOSPITAL AND CLINIC	MN	501(C)(3)	3	MCHS--SOUTHWEST MINNESOTA REGION	Yes
(20)ENGEBRETSON FAMILY CHARITABLE TRUST 6325 S RAINBOW BLVD STE 300 LAS VEGAS,NV89118 41-6445383	CHARITABLE TRUST	MN	501(C)(3)	12-II	N/A		No
(21)HAZEL HUGHES CHARITABLE TRUST PO BOX 470 PETERSBURG,IL62675 80-0030922	CHARITABLE TRUST	IL	501(C)(3)	12-III-FI	N/A		No
(22)NAEVE HEALTH CARE FOUNDATION 404 WEST FOUNTAIN ST ALBERT LEA,MN56007 41-1989509	FUNDRAISING FOUNDATION	MN	501(C)(3)	12-III-FI	N/A		No
(23)THE HIRSH FAMILY FOUNDATION 108 NORTH MAIN STREET AUSTIN,MN55912 41-1749842	FUNDRAISING FOUNDATION	MN	501(C)(3)	12-I	N/A		No
(24)DREW FOUNDATION PO BOX 2578 JACKSONVILLE,FL322032578 59-6669745	CHARITABLE TRUST	FL	501(C)(3)	12-I	N/A		No
(25)HORMEL FOUNDATION 329 N MAIN ST SUITE 102L AUSTIN,MN55912 41-0694716	FUNDRAISING FOUNDATION	MN	501(C)(3)	12-I	N/A		No

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50135Y

Schedule R (Form 990) 2021

Page 2

Part III

Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related organizations treated as a partnership during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Predominant income(related, unrelated, excluded from tax under sections 512-514)	(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?		(k) Percentage ownership
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity		(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No	(k) Percentage ownership
(1) FRANKLIN HEATING STATION 200 FIRST STREET SW ROCHESTER,MN55905 41-0264830	UTILITY	MN	MAYO CLINIC	EXCLUDED	119	50,281,490		No		Yes		84.050 %
(2) LATIGO PETROLEUM LLC PO BOX 14230 ODESSA,TX79768 36-4767494	OIL & GAS EXPLORATION	DE	MAYO CLINIC	UNRELATED	22,627,065	100,323,499		No	12,162,444	Yes		65.000 %
(3) MAYO CLINIC HEALTHCARE LLP 15 PORTLAND PLACE LONDON UK	HEALTHCARE	UK	MAYO CLINIC (UK) LTD	UNRELATED				No			No

Part IV

Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets	(h) Percentage ownership	(i) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets	(h) Percentage ownership	Yes	No
(1) MAYO CLINIC SUPPORT SERVICES TEXAS 200 FIRST STREET SW ROCHESTER,MN55905 47-1751102	HEALTH SERVICES	TX	MAYO CLINIC	C	119,305	116,297	100.000 %	Yes
(2) MAYO CLINIC UK LTD 3 MORE LONDON RIVERSIDE LONDON UK	INVESTMENT ACTIVITIES	UK	MAYO CLINIC	C	14,002	46,925,069	100.000 %	Yes
(3) MAYO HOLDING COMPANY 200 FIRST STREET SW ROCHESTER,MN55905 41-1578020	HOLDING COMPANY	MN	MAYO CLINIC	C	8,971	62,232,334	100.000 %	Yes
(4) MAYO INSURANCE COMPANY LTD 200 FIRST STREET SW ROCHESTER,MN55905	SELF INSURANCE POOL	CJ	MAYO CLINIC	C	27,438,604	155,078,910	100.000 %	Yes
(5) MCHS--DECORAH CLINIC PHYSICIANS 907 MONTGOMERY STREET DECORAH,IA52101 41-1711329	PATIENT CARE - CLINIC	IA	MAYO HOLDING COMPANY	C				Yes
(6) RESOUNDANT INC 421 1ST AVE SW SUITE 204W ROCHESTER,MN55902 46-1661978	MANUFACTURING MEDICAL DEVICE COMPONENT	MN	MFMER	C				Yes
(7) ROCHESTER AIRPORT COMPANY 200 FIRST STREET SW ROCHESTER,MN55905 41-0506870	AIRPORT MANAGEMENT	MN	MAYO HOLDING COMPANY	C				Yes
(8) SUPERBLOCK 3 PROPERTY OWNERS ASSOCIATION 13400 E SHEA BLVD SCOTTSDALE,AZ85259 86-0870505	COMMERCIAL PROPERTY OWNERS ASSOCIATION	AZ	MAYO CLINIC ARIZONA	C				Yes
(9) THE STABILE BUILDING OWNERS' ASSOCIATION 200 FIRST STREET SW ROCHESTER,MN55905 20-8994499	COMMERCIAL PROPERTY OWNERS ASSOCIATION	MN	MAYO CLINIC	C			85.000 %	Yes
(10) MC ALLIANCE LTD 200 FIRST STREET SW ROCHESTER,MN55905 98-1527769	HEALTHCARE AND ADMINISTRATIVE SERVICES	CJ	MC INTERNATIONAL	C	25,596,061	14,872,715	100.000 %	Yes
(11) MAYO CLINIC UK 2 LTD 3 MORE LONDON RIVERSIDE LONDON UK	INVESTMENT ACTIVITIES	UK	MAYO CLINIC UK LTD	C				Yes
(12) CHARITABLE LEAD TRUST	CHARITABLE TRUST	CA	MAYO CLINIC	T	1,176,311	10,453,074	89.000 %	Yes
(13) PERPETUAL TRUST	CHARITABLE TRUST	LA	MAYO CLINIC	T	129,871	2,352,796	100.000 %	Yes
(14) PERPETUAL TRUST (2)	CHARITABLE TRUST	MA	MAYO CLINIC	T				Yes
(15) PERPETUAL TRUST	CHARITABLE TRUST	MO	MAYO CLINIC	T	6,440	203,253	100.000 %	Yes
(16) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	AZ	MAYO CLINIC	T		171,821	60.000 %	Yes
(17) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	CO	MAYO CLINIC	T		998,493	100.000 %	Yes
(18) CHARITABLE REMAINDER TRUST (7)	CHARITABLE TRUST	FL	MAYO CLINIC	T				Yes
(19) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	MA	MAYO CLINIC	T		222,860	100.000 %	Yes
(20) CHARITABLE REMAINDER TRUST (93)	CHARITABLE TRUST	MN	MAYO CLINIC	T				Yes
(21) CHARITABLE REMAINDER TRUST (4)	CHARITABLE TRUST	NC	MAYO CLINIC	T				Yes
(22) CHARITABLE REMAINDER TRUST (2)	CHARITABLE TRUST	NV	MAYO CLINIC	T				Yes
(23) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	TX	MAYO CLINIC	T		709,184	100.000 %	Yes
(24) PERPETUAL TRUST	CHARITABLE TRUST	ND	MFMER	T				Yes
(25) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	CO	MFMER	T				Yes
(26) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	FL	MFMER	T				Yes
(27) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	IL	MFMER	T				Yes
(28) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	MI	MFMER	T				Yes
(29) CHARITABLE REMAINDER TRUST (45)	CHARITABLE TRUST	MN	MFMER	T				Yes
(30) CHARITABLE REMAINDER TRUST (6)	CHARITABLE TRUST	MN	MCHS--SOUTHWEST MINNESOTA REGION	T				Yes
(31) CHARITABLE REMAINDER TRUST	CHARITABLE TRUST	WI	MCHS--NORTHWEST WISCONSIN REGION INC	T				Yes

Schedule R (Form 990) 2021

Page 3

Part V

Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.

Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.

Yes

1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?

a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................

Yes

b Gift, grant, or capital contribution to related organization(s) ............................

Yes

c Gift, grant, or capital contribution from related organization(s) ............................

Yes

d Loans or loan guarantees to or for related organization(s) ............................

e Loans or loan guarantees by related organization(s) ............................

f Dividends from related organization(s) ............................

g Sale of assets to related organization(s) ............................

h Purchase of assets from related organization(s) ............................

i Exchange of assets with related organization(s) ............................

j Lease of facilities, equipment, or other assets to related organization(s) .......................

k Lease of facilities, equipment, or other assets from related organization(s) ......................

l Performance of services or membership or fundraising solicitations for related organization(s) .....................

Yes

m Performance of services or membership or fundraising solicitations by related organization(s) .................

Yes

n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................

Yes

o Sharing of paid employees with related organization(s) ............................

p Reimbursement paid to related organization(s) for expenses ............................

Yes

q Reimbursement paid by related organization(s) for expenses ............................

Yes

r Other transfer of cash or property to related organization(s) ............................

Yes

s Other transfer of cash or property from related organization(s) ............................

Yes

If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.

(a) Name of related organization	(b) Transaction type (a-s)	(c) Amount involved	(d) Method of determining amount involved
(1) CHARTERHOUSE INC	A	32,417	GAAP
(2) CHARTERHOUSE INC	N	92,336	GAAP
(3) CHARTERHOUSE INC	P	72,834	GAAP
(4) CHARTERHOUSE INC	Q	1,423,484	GAAP
(5) CHARTERHOUSE INC	R	5,749,401	GAAP
(6) CHARTERHOUSE INC	S	2,939,680	GAAP
(7) MAYO CLINIC AMBULANCE	A	684,445	GAAP
(8) MAYO CLINIC AMBULANCE	P	7,012,595	GAAP
(9) MAYO CLINIC AMBULANCE	Q	526,174	GAAP
(10) MAYO CLINIC AMBULANCE	S	8,299,983	GAAP
(11) MAYO CLINIC ARIZONA	A	21,644,369	GAAP
(12) MAYO CLINIC ARIZONA	B	201,738,735	GAAP
(13) MAYO CLINIC ARIZONA	C	242,454,051	GAAP
(14) MAYO CLINIC ARIZONA	L	10,932,408	GAAP
(15) MAYO CLINIC ARIZONA	M	353,008	GAAP
(16) MAYO CLINIC ARIZONA	N	1,296,019	GAAP
(17) MAYO CLINIC ARIZONA	P	623,012	GAAP
(18) MAYO CLINIC ARIZONA	Q	12,005,478	GAAP
(19) MAYO CLINIC ARIZONA	R	90,079,625	GAAP
(20) MAYO CLINIC ARIZONA	S	81,984	GAAP
(21) MAYO CLINIC FLORIDA	A	9,280,228	GAAP
(22) MAYO CLINIC FLORIDA	B	55,292	GAAP
(23) MAYO CLINIC FLORIDA	L	2,948,881	GAAP
(24) MAYO CLINIC FLORIDA	N	17,223,301	GAAP
(25) MAYO CLINIC FLORIDA	Q	27,228,532	GAAP
(26) MAYO CLINIC HOSPITAL ROCHESTER	C	1,000,048,209	GAAP
(27) MAYO CLINIC HOSPITAL ROCHESTER	N	7,873,361	GAAP
(28) MAYO CLINIC HOSPITAL ROCHESTER	P	17,803,699	GAAP
(29) MAYO CLINIC HOSPITAL ROCHESTER	Q	192,942,620	GAAP
(30) MAYO CLINIC HOSPITAL ROCHESTER	R	5,201,079	GAAP
(31) MAYO CLINIC HOSPITAL ROCHESTER	S	204,338,916	GAAP
(32) MAYO CLINIC JACKSONVILLE	A	14,037,436	GAAP
(33) MAYO CLINIC JACKSONVILLE	B	243,328,986	GAAP
(34) MAYO CLINIC JACKSONVILLE	C	202,380,468	GAAP
(35) MAYO CLINIC JACKSONVILLE	L	7,656,504	GAAP
(36) MAYO CLINIC JACKSONVILLE	M	4,877,784	GAAP
(37) MAYO CLINIC JACKSONVILLE	N	21,143,425	GAAP
(38) MAYO CLINIC JACKSONVILLE	P	7,051,974	GAAP
(39) MAYO CLINIC JACKSONVILLE	Q	7,564,571	GAAP
(40) MAYO CLINIC JACKSONVILLE	R	58,519,079	GAAP
(41) MAYO CLINIC SUPPORT SERVICES TEXAS	L	133,399	GAAP
(42) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	B	1,048,484	GAAP
(43) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	C	2,279,545	GAAP
(44) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	N	32,746,036	GAAP
(45) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	P	4,967,913,053	GAAP
(46) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	Q	26,919,860	GAAP
(47) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	R	2,050,661	GAAP
(48) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH	S	258,362,064	GAAP
(49) MCHS FAIRMONT	A	1,057,736	GAAP
(50) MCHS FAIRMONT	B	68,291	GAAP
(51) MCHS FAIRMONT	C	353,465	GAAP
(52) MCHS FAIRMONT	L	731,369	GAAP
(53) MCHS FAIRMONT	N	1,423,422	GAAP
(54) MCHS FAIRMONT	P	175,129	GAAP
(55) MCHS FAIRMONT	Q	741,113	GAAP
(56) MCHS FAIRMONT	R	193,946	GAAP
(57) MCHS FRANCISCAN MEDICAL CENTER INC	A	4,441,279	GAAP
(58) MCHS FRANCISCAN MEDICAL CENTER INC	B	8,006,839	GAAP
(59) MCHS FRANCISCAN MEDICAL CENTER INC	C	18,681,358	GAAP
(60) MCHS FRANCISCAN MEDICAL CENTER INC	L	3,877,017	GAAP
(61) MCHS FRANCISCAN MEDICAL CENTER INC	M	132,365	GAAP
(62) MCHS FRANCISCAN MEDICAL CENTER INC	N	4,186,685	GAAP
(63) MCHS FRANCISCAN MEDICAL CENTER INC	P	12,696,021	GAAP
(64) MCHS FRANCISCAN MEDICAL CENTER INC	Q	10,781,787	GAAP
(65) MCHS FRANCISCAN MEDICAL CENTER INC	R	319,432	GAAP
(66) MCHS LAKE CITY	A	469,708	GAAP
(67) MCHS LAKE CITY	B	83,341	GAAP
(68) MCHS LAKE CITY	L	247,155	GAAP
(69) MCHS LAKE CITY	N	220,204	GAAP
(70) MCHS LAKE CITY	Q	410,002	GAAP
(71) MCHS NORTHWEST WISCONSIN REGION INC	A	12,530,446	GAAP
(72) MCHS NORTHWEST WISCONSIN REGION INC	B	363,081	GAAP
(73) MCHS NORTHWEST WISCONSIN REGION INC	C	60,108,510	GAAP
(74) MCHS NORTHWEST WISCONSIN REGION INC	L	5,060,183	GAAP
(75) MCHS NORTHWEST WISCONSIN REGION INC	M	367,519	GAAP
(76) MCHS NORTHWEST WISCONSIN REGION INC	N	3,716,964	GAAP
(77) MCHS NORTHWEST WISCONSIN REGION INC	P	236,774	GAAP
(78) MCHS NORTHWEST WISCONSIN REGION INC	Q	15,446,232	GAAP
(79) MCHS NORTHWEST WISCONSIN REGION INC	R	2,369,143	GAAP
(80) MCHS SOUTHEAST MINNESOTA REGION	A	7,373,073	GAAP
(81) MCHS SOUTHEAST MINNESOTA REGION	B	14,222,643	GAAP
(82) MCHS SOUTHEAST MINNESOTA REGION	C	10,013,873	GAAP
(83) MCHS SOUTHEAST MINNESOTA REGION	L	6,121,200	GAAP
(84) MCHS SOUTHEAST MINNESOTA REGION	N	5,152,766	GAAP
(85) MCHS SOUTHEAST MINNESOTA REGION	P	85,351	GAAP
(86) MCHS SOUTHEAST MINNESOTA REGION	Q	10,729,320	GAAP
(87) MCHS SOUTHEAST MINNESOTA REGION	R	64,040	GAAP
(88) MCHS SOUTHWEST MINNESOTA REGION	A	8,256,071	GAAP
(89) MCHS SOUTHWEST MINNESOTA REGION	B	3,531,711	GAAP
(90) MCHS SOUTHWEST MINNESOTA REGION	C	11,303,587	GAAP
(91) MCHS SOUTHWEST MINNESOTA REGION	L	4,356,408	GAAP
(92) MCHS SOUTHWEST MINNESOTA REGION	M	399,730	GAAP
(93) MCHS SOUTHWEST MINNESOTA REGION	N	5,066,324	GAAP
(94) MCHS SOUTHWEST MINNESOTA REGION	P	1,304,678	GAAP
(95) MCHS SOUTHWEST MINNESOTA REGION	Q	10,913,240	GAAP
(96) MCHS SOUTHWEST MINNESOTA REGION	R	175,109	GAAP
(97) MCHS ST JAMES	L	200,336	GAAP
(98) MCHS ST JAMES	N	584,248	GAAP
(99) MCHS ST JAMES	Q	266,699	GAAP
(100) MCHS ST JAMES	R	79,767	GAAP
(101) RESOUNDANT INC	P	131,040	GAAP

Schedule R (Form 990) 2021

Page 4

Part VI

Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.

Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.

(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(e) Are all partners section 501(c)(3) organizations?		(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?		(k) Percentage ownership
(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	Yes	No	(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No	(k) Percentage ownership

Schedule R (Form 990) 2021

Page 5

Part VII

Supplemental Information

Provide additional information for responses to questions on Schedule R. See instructions.

Return Reference	Explanation

Schedule R (Form 990) 2021

Additional Data

Software ID:
Software Version:

1	Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
2	Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
3	Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
4	Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .	Yes	No
5	Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
6	Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No