Attach to Form 990 or Form 990-EZ.
Go to
www.irs.gov/Form990 for instructions and the latest information.
| (i) Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 10 above (see instructions)) | (iv) Is the organization listed in your governing document? | (v) Amount of monetary support (see instructions) | (vi) Amount of other support (see instructions) | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
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Total |
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Calendar year
(or fiscal year beginning in)
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(a) 2017 | (b) 2018 | (c) 2019 | (d) 2020 | (e) 2021 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") .. | 51,441,732 | 63,291,987 | 59,972,314 | 50,983,746 | 99,456,148 | 325,145,927 |
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf.... | 0 | |||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | 0 | |||||
| 4 | Total. Add lines 1 through 3 | 51,441,732 | 63,291,987 | 59,972,314 | 50,983,746 | 99,456,148 | 325,145,927 |
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) .. | 20,149,718 | |||||
| 6 | Public support. Subtract line 5 from line 4. | 304,996,209 | |||||
Calendar year
(or fiscal year beginning in)
![]() |
(a) 2017 | (b) 2018 | (c) 2019 | (d) 2020 | (e) 2021 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | 51,441,732 | 63,291,987 | 59,972,314 | 50,983,746 | 99,456,148 | 325,145,927 |
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | 5,667,273 | 5,221,701 | 4,928,838 | 1,217,543 | 1,156,360 | 18,191,715 |
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. | 124,523 | 34,200 | 86,442 | 15,070 | 3,574 | 263,809 |
| 11 | Total support. Add lines 7 through 10 | 343,601,451 | |||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2017 | (b) 2018 | (c) 2019 | (d) 2020 | (e) 2021 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513 ..... | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge | ||||||
| 6 | Total. Add lines 1 through 5 | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support. (Subtract line 7c from line 6.) | ||||||
Calendar year (or fiscal year beginning in) ![]() |
(a) 2017 | (b) 2018 | (c) 2019 | (d) 2020 | (e) 2021 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||
| Section A - Adjusted Net Income | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Net short-term capital gain | 1 | ||||
| 2 | Recoveries of prior-year distributions | 2 | ||||
| 3 | Other gross income (see instructions) | 3 | ||||
| 4 | Add lines 1 through 3 | 4 | ||||
| 5 | Depreciation and depletion | 5 | ||||
| 6 | Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) | 6 | ||||
| 7 | Other expenses (see instructions) | 7 | ||||
| 8 | Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) | 8 | ||||
| Section B - Minimum Asset Amount | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): | 1 | ||||
| a | Average monthly value of securities | 1a | ||||
| b | Average monthly cash balances | 1b | ||||
| c | Fair market value of other non-exempt-use assets | 1c | ||||
| d | Total (add lines 1a, 1b, and 1c) | 1d | ||||
| e |
Discount claimed for blockage or other factors (explain in detail in Part VI): |
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| 2 | Acquisition indebtedness applicable to non-exempt use assets | 2 | ||||
| 3 | Subtract line 2 from line 1d | 3 | ||||
| 4 | Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions). | 4 | ||||
| 5 | Net value of non-exempt-use assets (subtract line 4 from line 3) | 5 | ||||
| 6 | Multiply line 5 by 0.035 | 6 | ||||
| 7 | Recoveries of prior-year distributions | 7 | ||||
| 8 | Minimum Asset Amount (add line 7 to line 6) | 8 | ||||
| Section C - Distributable Amount | Current Year | |||||
| 1 | Adjusted net income for prior year (from Section A, line 8, Column A) | 1 | ||||
| 2 | Enter 85% of line 1 | 2 | ||||
| 3 | Minimum asset amount for prior year (from Section B, line 8, Column A) | 3 | ||||
| 4 | Enter greater of line 2 or line 3 | 4 | ||||
| 5 | Income tax imposed in prior year | 5 | ||||
| 6 | Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) | 6 | ||||
| Section D - Distributions | Current Year | |
|---|---|---|
| 1 Amounts paid to supported organizations to accomplish exempt purposes | 1 | |
|
2
Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity |
2 | |
| 3 Administrative expenses paid to accomplish exempt purposes of supported organizations | 3 | |
| 4 Amounts paid to acquire exempt-use assets | 4 | |
| 5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI) | 5 | |
| 6 Other distributions (describe in Part VI). See instructions | 6 | |
| 7Total annual distributions. Add lines 1 through 6. | 7 | |
|
8
Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions |
8 | |
| 9 Distributable amount for 2021 from Section C, line 6 | 9 | |
| 10 Line 8 amount divided by Line 9 amount | 10 | |
| Section E - Distribution Allocations (see instructions) |
(i) Excess Distributions |
(ii) Underdistributions Pre-2021 |
(iii) Distributable Amount for 2021 |
|
|---|---|---|---|---|
| 1 Distributable amount for 2021 from Section C, line 6 | ||||
|
2
Underdistributions, if any, for years prior to 2021 (reasonable cause required-- explain in Part VI). See instructions. |
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| 3 Excess distributions carryover, if any, to 2021: | ||||
| a From 2016....... | ||||
| b From 2017....... | ||||
| c From 2018....... | ||||
| d From 2019....... | ||||
| e From 2020....... | ||||
| fTotal of lines 3a through e | ||||
| g Applied to underdistributions of prior years | ||||
| h Applied to 2021 distributable amount | ||||
|
i
Carryover from 2016 not applied (see instructions) |
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| j Remainder. Subtract lines 3g, 3h, and 3i from line 3f. | ||||
| 4Distributions for 2021 from Section D, line 7: | ||||
| $ | ||||
| a Applied to underdistributions of prior years | ||||
| b Applied to 2021 distributable amount | ||||
| c Remainder. Subtract lines 4a and 4b from line 4. | ||||
|
5
Remaining underdistributions for years prior to 2021, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions. |
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|
6
Remaining underdistributions for 2021. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions. |
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|
7 Excess distributions carryover to 2022. Add lines 3j and 4c. |
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| 8 Breakdown of line 7: | ||||
| a Excess from 2017..... | ||||
| b Excess from 2018..... | ||||
| c Excess from 2019..... | ||||
| d Excess from 2020..... | ||||
| e Excess from 2021..... | ||||
| Facts And Circumstances Test |
|---|
| Return Reference | Explanation |
|---|---|
| Schedule A, Part II, Line 10 Other Income | DESCRIPTION - OTHER INCOME, COLUMN A - 124523.0, COLUMN B - 34200.0, COLUMN C - 86442.0, COLUMN D - 15070.0, COLUMN E - 3574.0, COLUMN F - 263809.0; |
| Software ID: | 21014044 |
| Software Version: | 2021v4.2 |
Attach to Form 990 or 990-EZ.
Go to www.irs.gov/Form990 for the latest information.
| Return Reference | Explanation |
|---|---|
| Form 990, Part I, Line 6 VOLUNTEERS | VOLUNTEERS SERVE IN A VARIETY OF WAYS, BUT THE GREATEST NUMBERS OF VOLUNTEERS ASSIST WITH THE MORE THAN PINK WALKS, RACE FOR THE CURE RUNS, AND THE SUSAN G. KOMEN 3 DAY SERIES. |
| Form 990, Part III, Line 4 Program service accomplishments | SUSAN G. KOMEN'S MISSION IS TO SAVE LIVES FROM BREAST CANCER, BY FINDING BREAKTHROUGHS TO PREVENT, DETECT, TREAT, AND CURE BREAST CANCER, AND BY MEETING MOST CRITICAL NEEDS IN COMMUNITIES TO ENSURE EVERYONE GETS THE BREAST CANCER CARE THEY NEED WHEN THEY NEED IT. KOMEN TAKES A 360 DEGREE APPROACH TO FIGHT BREAST CANCER THROUGH . RESEARCH, TO DRIVE BREAKTHROUGHS THAT WILL BRING US NEW KNOWLEDGE AND ADVANCES IN CARE FOR ALL, . COMMUNITY HEALTH, TO EMPOWER PEOPLE WITH TRUSTWORTHY INFORMATION AND SUPPORT PEOPLE IN THEIR BREAST HEALTH JOURNEY THROUGH DIRECT SERVICES, COMMUNITY PROGRAMS AND HEALTH SYSTEMS CHANGE. . AND PUBLIC POLICY, WHERE WE ADVOCATE FOR POLICIES TO CREATE SYSTEMIC AND LASTING CHANGES THAT WILL FUND AND FACILITATE RESEARCH AND ALLEVIATE THE BURDEN ON PATIENTS AND PROTECT ACCESS TO AFFORDABLE, HIGH-QUALITY HEALTH CARE FOR ALL. KOMEN IS A LEADING GLOBAL BREAST CANCER ORGANIZATION, HAVING FUNDED MORE BREAST CANCER RESEARCH THAN ANY OTHER NONPROFIT OUTSIDE OF THE U.S. GOVERNMENT WHILE PROVIDING REAL TIME HELP TO THOSE FACING THE DISEASE. SINCE ITS FOUNDING IN 1982, KOMEN HAS FUNDED nearly $1.1 BILLION IN BREAST CANCER RESEARCH IN MORE THAN 2700 GRANTS AND more than 500 CLINICAL TRIALS CONDUCTED BY THOUSANDS OF THE WORLD'S BEST AND BRIGHTEST RESEARCHERS ACROSS THE US AND AROUND THE WORLD. KOMEN HAS ALSO PROVIDED OVER $2.3 BILLION IN FUNDING FOR PATIENT NAVIGATION, SCREENING, DIAGNOSIS, TREATMENT, EDUCATION , ADVOCACY, AND PSYCHOSOCIAL SUPPORT PROGRAMS SERVING MILLIONS OF PEOPLE IN MORE THAN 60 COUNTRIES WORLDWIDE. KOMEN WAS FOUNDED BY NANCY G. BRINKER, WHO PROMISED HER SISTER, SUSAN G. KOMEN, THAT SHE WOULD END THE DISEASE THAT CLAIMED SUZY'S LIFE. WITH THIS INVESTMENT, KOMEN IS SUPPORTING LABORATORY RESEARCH, TRANSLATIONAL STUDIES, AND CLINICAL TRIALS THAT ARE PAVING THE ROAD WITH SCIENTIFIC DISCOVERIES THAT ARE: - UNRAVELLING THE BIOLOGY OF BREAST CANCER, - LEADING TO THE DEVELOPMENT OF NEW BREAST CANCER DRUGS, - DEVELOPMENT OF NEW TECHNOLOGIES AND TESTS, AND - NEW INTERVENTIONS THAT ARE CHANGING THE STANDARD OF BREAST CANCER CARE AND IMPROVING THE DELIVERY OF THAT CARE. OUR GOAL IS TO ADVANCE PERSONALIZED MEDICINE AND IMPROVE HEALTH OUTCOMES FOR EVERYONE. KOMEN HAS HAD MORE THAN 680 RESEARCH DISCOVERIES SINCE WE STARTED TRACKING THEM IN 2016 THAT ARE MOVING US CLOSER TO THAT GOAL. NEARLY TWO-THIRDS OF THESE DISCOVERIES FOCUS ON OUR RESEARCH PRIORITIES OF CONQUERING METASTATIC AND AGGRESSIVE BREAST CANCERS AND ELIMINATING BREAST CANCER DISPARITIES. THEY INCLUDE SUCH THINGS AS NEW BIOMARKERS, NEW DRUG TARGETS, NEW TREATMENTS, AND NEW HEALTHCARE DELIVERY TOOLS IN PAVING THIS ROAD WITH SCIENTIFIC DISCOVERIES, WE'RE ALSO PAVING IT WITH HOPE. THE HOPE THAT NEW WAYS TO DETECT, DIAGNOSE, TREAT, PREVENT AND, ULTIMATELY, CURE BREAST CANCER ARE AROUND THE CORNER. THERE WHEN PEOPLE WITH BREAST CANCER NEED THEM TO ALLOW THEM TO LIVE LONGER, WITH IMPROVED QUALITY OF LIFE. RESEARCH SINCE ITS FOUNDING IN 1982, KOMEN'S RESEARCH INVESTMENTS HAVE CONTRIBUTED TO MANY MAJOR ADVANCES IN BREAST CANCER SCIENCE. THE PROGRESS HAS BEEN SIGNIFICANT - TODAY, WE KNOW THAT BREAST CANCER IS MORE THAN A SINGLE DISEASE. WE HAVE A BETTER UNDERSTANDING OF THE GENETICS OF BREAST CANCER AND THE CRITICAL NEED TO TAILOR SCREENING, DIAGNOSIS, TREATMENT, AND PREVENTION STRATEGIES TO INDIVIDUALS THROUGH ADVANCES IN PRECISION MEDICINE. KOMEN'S RESEARCH PROGRAMS ARE FOCUSED ON BREAKTHROUGH RESEARCH TO PREVENT AND CURE BREAST CANCER THROUGH BETTER APPROACHES FOR EARLY DETECTION AND DIAGNOSIS, UNDERSTANDING METASTASIS AND RECURRENCE, DEVELOPING NOVEL THERAPIES FOR ALL STAGES OF BREAST CANCER, AND DEVELOPING NEW APPROACHES TO ADDRESS DISPARITIES IN BREAST CANCER OUTCOMES, WITH THE GOAL OF SUPPORTING WORK THAT HAS SIGNIFICANT POTENTIAL TO LEAD TO NEW TREATMENTS, TECHNOLOGIES AND INTERVENTIONS. KOMEN'S RESEARCH PROGRAMS ARE GUIDED BY 46 OF THE WORLD'S LEADERS IN BREAST CANCER RESEARCH, ONCOLOGY AND ADVOCACY. THE SCIENTIFIC ADVISORY BOARD ASSISTS KOMEN IN SETTING ITS RESEARCH STRATEGY AND PRIORITIZING ITS RESEARCH INVESTMENT. THE KOMEN SCHOLARS LEAD AND PARTICIPATE IN KOMEN'S WORLD-CLASS SCIENTIFIC PEER REVIEW PROCESS. OUR ADVOCATES IN SCIENCE BRING THE COLLECTIVE PATIENT VOICE TO KOMEN'S RESEARCH PROGRAMS AND SCIENTIFIC ACTIVITIES, EMPHASIZING URGENCY AND PATIENT IMPACT. THIS YEAR WE ANNOUNCED THE NEW CLASS OF SIX ESTEEMED BREAST CANCER RESEARCHERS AND TWO NEW PATIENT ADVOCATES TO THE KOMEN SCHOLARS. THESE WOMEN AND MEN JOIN AN EXCLUSIVE GROUP OF BREAST CANCER RESEARCHERS, CLINICIANS AND ADVOCATES WHO HELP GUIDE THE ORGANIZATION'S WORK TO SAVE LIVES AND END BREAST CANCER. KOMEN AWARDS GRANTS TO INDIVIDUAL SCIENTISTS, RESEARCH TEAMS, AND ORGANIZATIONS AROUND THE WORLD THROUGH A FAIR, TRANSPARENT, RIGOROUS, AND COMPETITIVE REVIEW PROCESS THAT ENSURES MAXIMUM IMPACT FOR OUR RESEARCH INVESTMENT. IN FY22, KOMEN AWARDED 48 GRANTS THROUGH ITS RESEARCH PROGRAMS TO SUPPORT SCIENTIFIC RESEARCH, IN THE UNITED STATES, AND CANADA. CAREER CATALYST RESEARCH GRANTS SUPPORT EARLY CAREER INVESTIGATORS CONDUCTING OUTSTANDING RESEARCH THAT WILL USE LIQUID BIOPSY TECHNOLOGY TO IMPROVE THE TREATMENT AND EARLY DETECTION OF METASTATIC BREAST CANCER. LEADERSHIP GRANTS SUPPORT KOMEN SCHOLARS PURSUING INNOVATIVE RESEARCH PROJECTS WHICH WILL IMPROVE THE UNDERSTANDING, DETECTION, TREATMENT OR PREVENTION OF BREAST CANCER, WITH A FOCUS ON CONQUERING METASTATIC BREAST CANCER AND ELIMINATING BREAST CANCER DISPARITIES. THE 48 RESEARCH GRANTS AWARDED IN FY22 ARE: CAREER CATALYST RESEARCH GRANTS: DANIEL HOLLERN, PH.D., OF SALK INSTITUTE FOR BIOLOGICAL STUDIES WILL IDENTIFY WAYS THAT METASTATIC TUMOR CELLS AVOID OR SUPPRESS THE IMMUNE SYSTEM'S B CELLS IN TRIPLE NEGATIVE BREAST CANCER (TNBC) PATIENTS, SPECIFICALLY PATIENTS THAT ALSO HAVE LIVER TUMORS. THE GOAL IS TO IMPROVE AN EXISTING TREATMENT CALLED ANTI-PDL1 THERAPY TO HELP BOOST B CELL ACTIVITY AND REDUCE MORTALITY IN TNBC PATIENTS WITH LIVER TUMORS. HARUKA ITAKURA, M.D., PH.D., OF STANFORD UNIVERSITY SCHOOL OF MEDICINE WILL CONDUCT A STUDY THAT WILL TAKE EXISTING MRI AND CT IMAGES COLLECTED FROM HER2+ BREAST CANCER PATIENTS AND USE ADVANCED DATA SCIENCE/AI TO IDENTIFY KEY FACTORS FOR PREDICTING FUTURE BRAIN METASTASIS. THE GOAL OF THIS STUDY IS TO USE NON-INVASIVE TECHNIQUES TO IDENTIFY PATIENTS WITH HER2+ BREAST CANCER WHO ARE ALSO AT RISK FOR DEVELOPING METASTATIC BRAIN TUMORS. MARIYA ROZENBLIT, M.D., OF YALE CANCER CENTER WILL CONDUCT A CLINICAL TRIAL TO EVALUATE VARIOUS THERAPIES OFFERED TO PATIENTS WITH STAGE 4 OLIGOMETASTATIC BREAST CANCER (OMBC) AND TO CREATE AN ONLINE PLATFORM THAT REGISTERS STAGE 4 OMBC PATIENTS, STANDARDIZES THE TREATMENT APPROACH AND ENABLES FOLLOW-UP DATA COLLECTION. DR. ROZENBLIT HOPES THIS COLLECTED DATA WILL DEMONSTRATE HOW THESE TREATMENT OPTIONS MAY PROMOTE LONG-TERM SURVIVAL AND FUTURE PREVENTION OF METASTATIC BREAST CANCER FOR THESE PATIENTS. TARAH BALLINGER, M.D., OF INDIANA UNIVERSITY WILL PILOT A 16-WEEK EXERCISE INTERVENTION FOR METASTATIC BREAST CANCER (MBC) PATIENTS TO DETERMINE WHETHER THE ADDITION OF EXERCISE TO THEIR COMPREHENSIVE CARE PLAN COULD IMPROVE LONG-TERM TREATMENT OUTCOMES. MARIA SOSA, PH.D., OF ICHAN SCHOOL OF MEDICINE WILL STUDY THE EFFECTIVENESS OF A NEW PROPOSED DRUG THERAPY THAT WILL BLOCK THE ACTIVITY OF ZFP296, A PROTEIN THAT IS BELIEVED TO PROMOTE TUMOR CELL GROWTH AND METASTASIS. PEDRAM RAZAVI, M.D., PH.D., OF MEMORIAL SLOAN KETTERING CANCER CENTER WILL ANALYZE CIRCULATING TUMOR CELL DNA (CTDNA) FROM EARLY-STAGE, HIGH RISK PATIENTS TO DETECT EARLY BREAST CANCER METASTASES OR ANY REMAINING BREAST CANCER CELLS AFTER TREATMENT (MINIMAL RESIDUAL DISEASE, OR MRD). DR. RAZAVI WILL USE THIS CTDNA TO IDENTIFY PERSONALIZED TREATMENTS FOR PATIENTS AT RISK FOR DEVELOPING MRD OR TREATMENT RESISTANCE, WITH THE ULTIMATE GOAL OF DECREASING THE RISK OF METASTATIC RECURRENCE AND MORTALITY. HAI WANG, PH.D., OF ROSWELL PARK CANCER INSTITUTE WILL STUDY BREAST CANCER CELL METASTASIS TO THE BONE AND THE METABOLIC CHANGES THESE METASTATIC CELLS GO THROUGH TO GROW IN THE BONE VERSUS THE PRIMARY TUMOR LOCATION IN THE BREAST. DR. WANG WILL INVESTIGATE HOW BREAST CANCER TUMOR CELLS THAT METASTASIZE TO THE BONE SWITCH THEIR SOURCE OF METABOLIC ENERGY PRODUCTION AND AIMS TO USE THESE FINDINGS TO EXPLORE NEW TREATMENT STRATEGIES THAT COULD IMPROVE SURVIVAL RATES FOR METASTATIC BREAST CANCER PATIENTS. |
| Form 990, Part III, Line 4 Program service accomplishments continued | SONYA REID, M.D., M.P.H., OF VANDERBILT UNIVERSITY WILL CONDUCT A CLINICAL TRIAL FOR PATIENTS WITH HORMONE RECEPTOR-POSITIVE (HR+, HER2-) METASTATIC BREAST CANCER (MBC) TO DETERMINE WHETHER A GENE PANEL TEST FOR GENETIC VARIATIONS IN HR+, HER2- MBC COULD INFORM MORE EFFECTIVE TREATMENT STRATEGIES, ESPECIALLY FOR BREAST CANCER TYPES THAT ARE MORE PREVALENT IN RACIAL/ETHNIC MINORITIES. THE GOAL OF THIS PROJECT IS TO CHARACTERIZE THE IMPACT OF GENETIC VARIATION ON MBC SURVIVAL AND DISPARATE OUTCOMES, AND TO DEVELOP MORE PERSONALIZED TREATMENTS THAT COULD IMPACT CLINICAL OUTCOMES AMONG A RACIALLY DIVERSE PATIENT POPULATION. SRINIVAS MALLADI, PH.D., OF THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER WILL STUDY AND TARGET DORMANT BREAST CANCER CELLS TO PREVENT THEM FROM RECURRING AND METASTASIZING TO THE BRAIN AND INTERACTING WITH BRAIN CELLS CALLED ASTROCYTES. BY ANALYZING HOW ASTROCYTES NOURISH NEIGHBORING BREAST CANCER CELLS IN THE BRAIN WITH FATTY ACIDS, THE GOAL IS TO EVALUATE THE IMPACT OF TARGETING THE CREATION OF THESE FATTY ACIDS TO PREVENT METASTATIC RECURRENCE. LEADERSHIP GRANTS: MELINDA TELLI, M.D., OF STANFORD UNIVERSITY WILL CONDUCT TWO CLINICAL TRIALS USING LIQUID BIOPSY TO TEST FOR CIRCULATING TUMOR DNA, AN INDICATOR OF RISK FOR RELAPSE IN PATIENTS WITH TRIPLE NEGATIVE BREAST CANCER (TNBC). THE HOPE IS THAT THIS LIQUID BIOPSY TECHNIQUE CAN BE USED TO MONITOR PATIENTS WHO ARE AT HIGHER RISK FOR A TNBC RELAPSE AND ALLOW FOR BETTER, MORE PERSONALIZED TREATMENTS. LAJOS PUSZTAI, M.D., OF YALE CANCER CENTER WILL TEST AN INNOVATIVE NEW TOOL FOR MEASURING TUMOR GROWTH, A NEW BIOMARKER FOR TRIPLE NEGATIVE BREAST CANCER (TNBC) TREATMENT GUIDANCE AND A NEW ANTI-CANCER THERAPY TARGETING CANCER METABOLISM. DR. PUSZTAI HOPES TO IMPROVE TNBC OUTCOMES AND PREVENT RECURRENCE OF METASTATIC TUMORS THROUGH THIS WORK. JULIE PALMER, SC.D., M.P.H., OF BOSTON UNIVERSITY WILL CONDUCT A STUDY THAT WILL USE TUMOR SAMPLES AND PSYCHOSOCIAL STRESS DATA FROM WOMEN ENROLLED IN THE BLACK WOMEN'S HEALTH STUDY TO DEMONSTRATE HOW PSYCHOSOCIAL STRESS IMPACTS BREAST CANCER BIOLOGY AND OUTCOMES. THE GOAL OF THIS PROJECT IS TO UNDERSTAND HOW PSYCHOSOCIAL STRESS INFLUENCES BREAST CANCER AND TO IDENTIFY POTENTIAL INTERVENTIONS TO REDUCE PSYCHOSOCIAL STRESS, AND TO REDUCE DISPARITIES IN BREAST CANCER MORTALITY FOR BLACK WOMEN. KOMEN SCIENTIFIC ADVISORY BOARD MEMBER KORNELIA POLYAK, M.D., PH.D., OF DANA FARBER CANCER INSTITUTE WILL DETERMINE HOW THE SIGNALING OF THE PROTEIN TRANSFORMING GROWTH FACTOR BETA (TGF) MAY CONTRIBUTE TO EARLY BREAST CANCER DEVELOPMENT, INCLUDING A SMALL MUTATION THAT IS MORE PREVALENT IN AFRICAN AMERICAN WOMEN. THIS RESEARCH WILL HELP TO IDENTIFY AT-RISK POPULATIONS AND POTENTIAL THERAPEUTIC TARGETS, WITH THE GOAL OF BETTER UNDERSTANDING AND ENDING BREAST CANCER HEALTH DISPARITIES AMONG AFRICAN AMERICAN WOMEN. YIBIN KANG, PH.D., OF PRINCETON UNIVERSITY WILL INVESTIGATE WHETHER THE ENZYME ALDH1A2 COULD BE A THERAPEUTIC TARGET FOR PREVENTING BREAST CANCER PROGRESSION. THE GOAL OF THIS RESEARCH IS TO BETTER UNDERSTAND THE IMMUNE SYSTEM'S IMPACT ON BREAST CANCER DEVELOPMENT AND TREATMENT WHILE ALSO EXPLORING THE THERAPEUTIC POTENTIAL OF ALDH1A2 AS A NEW TARGET TO ELIMINATE BREAST TUMORS AND METASTASIS. SOHRAB SHAH, PH.D., OF MEMORIAL SLOAN-KETTERING CANCER CENTER WILL PERFORM A STUDY USING TRIPLE-NEGATIVE BREAST CANCER (TNBC) TUMOR DNA AND LIQUID BIOPSY SAMPLES TO OBSERVE HOW IMMUNE CELLS AND TUMOR DNA MUTATIONS CAN EVOLVE OVER TIME WITH TREATMENT OR DISEASE PROGRESSION. THE GOAL OF THIS PROJECT IS TO DEVELOP A PREDICTIVE MODEL THAT CAN IDENTIFY THE OPTIMAL TIMEFRAME FOR INTERVENTION AFTER NEOADJUVANT CHEMOTHERAPY FOR TNBC PATIENTS THAT ARE AT THE HIGHEST RISK OF RELAPSE. STEFFI OESTERREICH, PH.D., OF UNIVERSITY OF PITTSBURGH WILL UNCOVER THE EVOLUTION OF ESTROGEN RECEPTOR POSITIVE (ER+) PRIMARY CANCER TO METASTATIC RECURRENCE USING TISSUE SAMPLES AND LIQUID BIOPSY, AND TO CREATE GUIDELINES FOR A RAPID AUTOPSY PROGRAM TO BETTER UNDERSTAND METASTATIC DISEASE. THIS WORK WILL CREATE RICH DATASETS FOR OTHER RESEARCHERS AND UNCOVER BETTER TREATMENT OPTIONS FOR PREVENTING THE RECURRENCE OF METASTATIC TUMORS. AMELIE RAMIREZ, DR.P.H., M.P.H., OF THE UNIVERSITY OF TEXAS HEALTH SCIENCES CENTER AT SAN ANTONIO WILL STUDY THE IMPACT OF A CULTURALLY ADAPTED, HOLISTIC BREAST CANCER SURVIVORSHIP PROGRAM ON LATINA BREAST CANCER SURVIVORS THAT INCLUDES YOGA, MEDITATION AND DIETARY GUIDANCE. THE GOAL OF THIS PROJECT IS TO IDENTIFY WHETHER A HOLISTIC SURVIVORSHIP PROGRAM CAN IMPROVE THE QUALITY OF LIFE AND HEALTH OUTCOMES FOR LATINA BREAST CANCER SURVIVORS. ALANA WELM, PH.D., OF THE UNIVERSITY OF UTAH WILL RESEARCH A MOLECULE CALLED SHORT FORM OF RON (SFRON) THAT IS CURRENTLY BEING STUDIED IN CLINICAL TRIALS AS A THERAPEUTIC TARGET TO BLOCK BREAST CANCER TUMOR AND METASTASIS GROWTH. DR. WELM WILL STUDY SFRON TO DETERMINE HOW IT FUNCTIONS IN METASTASIS, AND THE ANTI-TUMOR IMMUNE RESPONSE OF THE BODY. THE GOAL OF THIS PROJECT IS TO IDENTIFY HOW SFRON AND THE IMMUNE SYSTEM MAY BE HARNESSED TO DEVELOP MORE EFFECTIVE TREATMENTS FOR PATIENTS WITH METASTATIC BREAST CANCER. LEADERSHIP GRANTS - NEW KOMEN SCHOLARS: ALLISON KURIAN, M.D., OF STANFORD UNIVERSITY WILL TEST AN ETHNICALLY DIVERSE STUDY GROUP OF PATIENTS USING A NEW LIQUID BIOPSY TECHNIQUE THAT CAN DETECT PRIMARY AND RECURRENT BREAST CANCER AT AN EARLIER STAGE USING LESS GENETIC MATERIAL. THE GOAL OF THIS PROJECT IS TO IDENTIFY WHICH PATIENT POPULATIONS COULD BENEFIT FROM EARLIER BREAST CANCER DETECTION USING THIS NEW STRATEGY. SUNIL BADVE, M.D., FRCPATH, OF EMORY UNIVERSITY WILL STUDY THE STRUCTURAL DIVERSITY OF BREAST CANCER PATIENT TUMOR CELLS AND THEIR RESISTANCE TO TREATMENTS THAT USE CDK 4/6 INHIBITORS, AND TO USE THIS DATA TO DEVELOP NEW THERAPEUTIC STRATEGIES TO PREVENT RESISTANCE AND RECURRENCE NANCY LIN, M.D., OF DANA FARBER CANCER INSTITUTE WILL EXPLORE WAYS TO IMPROVE THE EFFECTIVENESS OF ANTIBODY-DRUG CONJUGATES FOR PATIENTS WITH METASTATIC BREAST CANCER (MBC). BY USING TISSUE AND PLASMA SAMPLES FROM PATIENTS TREATED WITH THESE DRUGS, DR. LIN AIMS TO UNCOVER HOW TO PREVENT RESISTANCE TO THESE THERAPIES OVER TIME AND IMPROVE LONG-TERM TREATMENT OUTCOMES FOR MBC PATIENTS. SARA M. TOLANEY, M.D., M.P.H., OF DANA FARBER CANCER INSTITUTE WILL TEST THE ABILITY OF AN ANTIBODY-DRUG CONJUGATE DRUG CALLED SACITUZUMAB GOVITECAN (SG) TO INCREASE RESPONSIVENESS TO PEMBROLIZUMAB TREATMENT IN METASTATIC TRIPLE NEGATIVE BREAST CANCER AND HR+/HER2- METASTATIC BREAST CANCER PATIENTS. THIS RESEARCH WILL HELP DETERMINE WHETHER COMBINATION THERAPY USING BOTH SG AND PEMBROLIZUMAB COULD IMPROVE LONG-TERM SURVIVAL OUTCOMES FOR MBC PATIENTS. CYNTHIA MA, M.D., PH.D., OF WASHINGTON UNIVERSITY WILL PERFORM A STUDY USING PATIENT TUMOR SAMPLES COLLECTED POST-SURGERY AND FOLLOWING ENDOCRINE THERAPY TO IDENTIFY GENETIC CHANGES AND MECHANISMS OF ENDOCRINE RESISTANCE. DR. MA HOPES THAT THIS DATA WILL HELP TO IDENTIFY WHICH PATIENTS MAY DEVELOP RESISTANCE TO ENDOCRINE THERAPY AND GUIDE THE DEVELOPMENT OF MORE PERSONALIZED TREATMENTS THAT WILL SAVE LIVES. JORGE REIS-FILHO, M.D., PH.D., FRCPATH, OF MEMORIAL SLOAN-KETTERING CANCER CENTER WILL INVESTIGATE HOW DEFECTS TO DNA REPAIR PROCESSES CAUSE INCREASED INSTABILITY AND RESISTANCE TO ANTI-ESTROGEN THERAPY IN ESTROGEN RECEPTOR POSITIVE (ER+) BREAST CANCER CELLS. THIS RESEARCH WILL PROVIDE VALUABLE INSIGHT INTO THE EVOLUTION OF THERAPEUTIC RESISTANCE OF ER+ BREAST CANCER CELLS THAT CAN BE USED FOR FUTURE DEVELOPMENT OF MORE EFFECTIVE TREATMENTS. SCIENTIFIC ADVISORY BOARD MEMBER ADRIAN LEE, PH.D., OF THE UNIVERSITY OF PITTSBURGH WILL DEVELOP AND CHARACTERIZE A LIVING BIOBANK FROM VARIOUS NORMAL AND BREAST CANCER SPECIMENS DERIVED FROM PATIENT SAMPLES. THIS BIOBANK WILL SERVE AS A PUBLIC RESOURCE FOR RESEARCHERS WITH A FOCUS ON DIVERSITY IN RACE (ANCESTRY) AND BREAST CANCER SUBTYPES AND WILL ACCELERATE RESEARCH LEADING TO NEW INSIGHTS IN DRUG RESISTANCE AND PROGRESSION, NEW THERAPEUTIC TARGETS, AND IMPROVED CLINICAL OUTCOMES. ANGELA DEMICHELE, M.D., M.S.C.E., OF THE UNIVERSITY OF PENNSYLVANIA WILL INVESTIGATE MINIMAL RESIDUAL DISEASE AND DORMANT TUMOR CELLS BY USING NEW ASSAYS TO DETECT DISSEMINATED TUMOR CELLS AND CTDNA IN PATIENT TUMOR AND BLOOD SAMPLES. SHE WILL IDENTIFY AT-RISK PATIENTS, DIFFERENTIATE BETWEEN DORMANT AND REACTIVATED BREAST CANCER CELLS, AND MORE ACCURATELY EVALUATE THE IMPACT OF TREATMENTS ON DORMANT CELLS, WITH THE GOAL OF PREVENTING METASTATIC BREAST CANCER RECURRENCE AND DEATH AND IMPROVING THE QUALITY OF LIFE FOR SURVIVORS. |
| Form 990, Part III, Line 4 Program service accomplishments continued | MARIANA CHAVEZ MACGREGOR, M.D., M.SC., FASCO, OF THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER WILL STUDY THE SOCIAL AND POLICY-LEVEL FACTORS THAT AFFECT BREAST CANCER PATIENTS FROM UNDERSERVED POPULATIONS WHO FREQUENTLY ENCOUNTER MORE BARRIERS TO SUCCESSFUL TREATMENT THAN OTHER PATIENTS. THE GOAL IS TO IDENTIFY WHAT FACTORS CREATE THESE DISPARITIES AND DEVELOP STRATEGIES THAT WILL STRENGTHEN THE QUALITY OF CARE AND IMPROVE TREATMENT OUTCOMES FOR UNDERSERVED PATIENTS. MBC COLLABORATIVE RESEARCH INITIATIVE MELISSA TROESTER M.D., PH.D. AND TERRY HYSLOP PH.D. ARE COLLABORATING ON A PROPOSAL TO LEVERAGE HIGH QUALITY, INDIVIDUAL-LEVEL TUMOR BIOLOGY AND SOCIAL DETERMINANTS OF HEALTH DATA IN THE CAROLINA BREAST CANCER STUDY (CBCS) DATA TOGETHER WITH COMMUNITY-LEVEL VARIABLES TO EVALUATE HOW STRESS CONTRIBUTES TO HIGHER METASTASIS AND WORSE BREAST CANCER OUTCOMES IN BLACK WOMEN WHEN COMPARED TO WHITE WOMEN. ZACH HARTMAN PH.D. AND BENJAMIN VINCENT M.D. WILL WORK TOGETHER ON A PROPOSAL TO DETERMINE HOW TO MAKE METASTATIC TRIPLE-NEGATIVE BREAST CANCERS MORE SENSITIVE TO IMMUNOTHERAPIES. THE COLLABORATORS PROPOSE A METHOD OF STIMULATING THE ANTI-TUMOR RESPONSE WITH VACCINE TECHNOLOGIES TO INDUCE A SUSTAINABLE, ROBUST, AND BROAD STIMULUS TO THE INNATE IMMUNE SYSTEM THAT WILL BE TESTED FOR THE ABILITY TO ELIMINATE DISTANT METASTASIS. JENIFER FREEDMAN PH.D., STEVEN PATIERNO PH.D., AND KATIE HOADLEY, PH.D. ARE COLLABORATING TO INVESTIGATE DIFFERENCES IN BREAST CANCER OUTCOME BY RACE AS BLACK WOMEN SUFFER DISPROPORTIONATELY AND WITH OFTEN A WORSE PROGNOSIS. THE STUDY LEADERS IDENTIFIED BIOLOGICAL DIFFERENCES IN CANCER BETWEEN AFRICAN AND EUROPEAN ANCESTRY THAT RESULTED FROM A PROCESS CALLED SPLICING. THE RESEARCHERS IN THIS PROPOSAL SEEK TO DETERMINE IF THESE DIFFERENCES CAUSE BREAST CANCER CELLS TO GROW AND SPREAD MORE QUICKLY. OPPORTUNITY GRANTS: MONICA M. BERTAGNOLLI, M.D., OF THE ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY WILL RECEIVE $249,429 TO PERFORM A GENOMIC ANALYSIS OF PAIRED GERMLINE AND PRE-TREATMENT TUMOR SAMPLES FROM POSTMENOPAUSAL WOMEN WITH STAGE 2 AND 3 ER+/HER2-NEGATIVE (HER2-) BREAST CANCER COLLECTED THROUGH THE ALTERNATE TRIAL. THE GOAL IS TO ESTIMATE THE EFFECT OF GENE MUTATIONS ON ENDOCRINE THERAPY RESISTANCE, DEVELOP BIOMARKER TESTS TO DETECT RESIDUAL DISEASE AND ADVANCE PRECISION MEDICINE CAPABILITIES IN THE FIELD OF ER+ BREAST CANCER. ETTA D. PISANO, M.D., OF THE ECOG-ACRIN CANCER RESEARCH GROUP WILL BE AWARDED $247,248 TO IMPLEMENT WAYS TO IMPROVE AFRICAN-AMERICAN PARTICIPATION IN THE TOMOSYNTHESIS MAMMOGRAPHIC IMAGING SCREENING TRIAL (TMIST) BIOSPECIMEN SUB-STUDY THROUGH THE DEVELOPMENT AND DISSEMINATION OF EDUCATIONAL MATERIALS HIGHLIGHTING THE IMPORTANCE OF PARTICIPATION IN BIOSPECIMEN RESEARCH. THIS PROJECT WILL INCREASE THE DIVERSITY OF PATIENT SAMPLES IN THE EXISTING BIOBANK THAT WILL BE USED TO SUPPORT FUTURE STUDIES FOCUSED ON BREAST CANCER SCREENING, DIAGNOSIS, AND TREATMENT INTERVENTIONS. NADINE M. TUNG, M.D., OF THE ECOG-ACRIN CANCER RESEARCH GROUP WILL BE AWARDED $249,256 TO EXPAND RESEARCH QUESTIONS IN THE COMPASSHER2 PCR TRIAL TO DETERMINE WHETHER UNIQUE BIOMARKERS IDENTIFIED IN STAGE 2 OR 3 HER2-POSITIVE (HER2+) BREAST CANCER PATIENT TUMOR SAMPLES CAN BE USED TO PREDICT OUTCOMES OF PRE-SURGERY THERAPY. THE GOAL OF THIS PROJECT IS TO PROVIDE DATA THAT CAN BE USED TO PERSONALIZE TREATMENT DECISIONS, IMPROVE QUALITY OF LIFE, AND OPTIMIZE TREATMENTS FOR PATIENTS DIAGNOSED WITH HER2+ BREAST CANCER. ANNA MARIA V. STORNIOLO, M.D., OF INDIANA UNIVERSITY (IU) WILL RECEIVE TWO OPPORTUNITY GRANTS TOTALING $1,803,000 TO SUPPORT THE SUSAN G. KOMEN TISSUE BANK (KTB) AT THE IU SIMON CANCER CENTER, THE WORLD'S ONLY BIOREPOSITORY OF NORMAL BREAST TISSUE. THESE GRANTS SUPPORT THE COLLECTION AND STORAGE OF BIOSAMPLES, INCLUDING WHOLE BLOOD, DNA, SERUM, PLASMA, AND HEALTHY BREAST TISSUE FROM WOMEN NOT KNOWN TO HAVE BREAST CANCER, AS WELL AS THE DISTRIBUTION OF THE SAMPLES TO RESEARCHERS WORLDWIDE. ACCESS TO THESE NORMAL TISSUE SAMPLES PROVIDE RESEARCHERS THE OPPORTUNITY TO UNDERSTAND THE CHANGES THAT HAPPEN IN A NORMAL BREAST AND HOW THESE MOLECULAR MECHANISMS ARE ALTERED IN THE MALIGNANT PROCESS. EDUCATION KOMEN IS A TRUSTED SOURCE OF BREAST CANCER INFORMATION FOR PEOPLE ALL OVER THE WORLD AND IS INSTRUMENTAL IN CONNECTING PEOPLE WITH THE RESOURCES THEY NEED IN THEIR FIGHT AGAINST BREAST CANCER. OUR WEBSITE, KOMEN.ORG, PROVIDES CURRENT, SAFE, ACCURATE, COMPREHENSIVE, AND UNBIASED INFORMATION ABOUT BREAST CANCER, BASED ON SCIENTIFIC EVIDENCE. CONTENT IS OFFERED IN A VARIETY OF FORMATS INCLUDING INTERACTIVE VIDEO USING ANIMATION AND VOICEOVER IN ENGLISH AND SPANISH, ILLUSTRATIONS, CHARTS, GRAPHS, AND SHORT VIDEOS TO MEET THE LEARNING PREFERENCES AND NEEDS OF OUR WEB VISITORS. THE ABOUT BREAST CANCER AND PORTIONS OF THE PATIENT & CAREGIVER SECTIONS OF KOMEN'S WEBSITE, CO-DEVELOPED WITH HARVARD MEDICAL SCHOOL FACULTY AND DANA-FARBER CANCER INSTITUTE STAFF, RECEIVED NEARLY 3 MILLION PAGE VIEWS DURING FY22. KOMEN LAUNCHED THE CLINICAL TRIALS INITIATIVE ON KOMEN.ORG WITH THE GOAL OF EDUCATING PEOPLE ABOUT THE ROLE CLINICAL TRIALS, INCLUDING THOSE FROM UNDER- REPRESENTED POPULATIONS, AND EMPOWERING PEOPLE WITH INFORMATION ON TRIALS AND RESOURCES, INCLUDING OUR CLINIAL TRIALS HELPLINE. THE RESOURCES HELP TO ENSURE PATIENTS ARE EQUIPPED TO MAKE INFORMED DECISIONS REGARDING TRIAL PARTICIPATION IN PARTNERSHIP WITH THEIR HEALTH CARE PROVIDERS. THE INITIATIVE ALSO RAISES AWARENESS OF THE DIFFERENT TYPES OF TRIALS, INCLUDING TRIALS SUPPORTED BY KOMEN, FOCUSED ON RISK, SCREENING AND EARLY DETECTION, TREATMENT, FAMILY SUPPORT, QUALITY OF LIFE AND SURVIVORSHIP. KOMEN ALSO PROVIDES EVIDENCE-BASED, EASY-TO-READ EDUCATIONAL MATERIALS IN DOWNLOADABLE FORMATS ON KOMEN.ORG. EXAMPLES OF KOMEN EDUCATIONAL MATERIALS INCLUDE: A) BREAST SELF-AWARENESS MESSAGE CARDS IN MORE THAN 40 LANGUAGES, B) BREAST CANCER SPECIFIC BROCHURES AND FACTSHEETS, C) BOOKLETS WITH SUPPORT INFORMATION FOR SURVIVORS AND CO-SURVIVORS, AND D) TOOLKITS FOR BREAST CANCER OUTREACH AND EDUCATION FOR HISPANIC/LATINO IN ENGLISH AND SPANISH, FOR BLACK AND AFRICAN AMERICAN COMMUNITIES AND FOR LESBIANS, BISEXUAL WOMEN AND TRANSGENDER AND QUESTIONING/QUEER PEOPLE. IN ADDITION, IN FY22 KOMEN CONTINUED TO SUPPORT THE METASTATIC BREAST CANCER (MBC) COMMUNITY BY HOSTING 25 VIRTUAL EVENTS THROUGH THE MBC IMPACT SERIES. THESE EVENTS PROVIDED PEOPLE LIVING WITH METASTATIC BREAST CANCER AND THEIR LOVED ONES A SAFE, COLLABORATIVE SPACE TO GATHER INFORMATION AND DISCOVER PRACTICAL RESOURCES TO HELP MAKE DECISIONS FOR IMPROVED PHYSICAL AND EMOTIONAL HEALTH. PATIENT SUPPORT AT KOMEN, WE ARE FOCUSED ON SAVING LIVES BY REMOVING BARRIERS AND ENSURING ALL PEOPLE RECEIVE THE CARE THEY NEED THROUGH KOMEN'S PATIENT CARE CENTER. OFFICIALLY LAUNCHED IN FY22, THE KOMEN PATIENT CARE CENTER IS A SUITE OF INTEGRATED DIRECT PATIENT PROGRAMS THAT ENSURE NO ONE FACES BREAST CANCER ALONE. THE PATIENT CARE CENTER PROGRAMS AND SERVICES INCLUDE THE BREAST CARE HELPLINE, SCREENING & DIAGNOSTICS PROGRAM, FINANCIAL ASSISTANCE PROGRAM, AND PATIENT NAVIGATION, ALL OF WHICH PROVIDE SUPPORT AND RESOURCES FOR PEOPLE IN LOCAL COMMUNITIES ACROSS THE COUNTRY. KOMEN'S PROGRAMS AND SERVICES REMOVE BARRIERS TO CARE AND WORK SEAMLESSLY TOGETHER SO A PERSON CAN ACCESS ALL THE PROGRAMS THROUGH ONE CENTRAL SOURCE. THE OVERARCHING GOAL OF OUR PATIENT CARE CENTER IS TO SAVE LIVES BY ENSURING PATIENTS STAY IN THE BREAST CANCER CONTINUUM OF CARE, OVERCOME BARRIERS AND CHALLENGES TO HIGH-QUALITY BREAST CARE SERVICES, COMPLETE TREATMENT, AND HAVE A HIGH QUALITY OF LIFE AND IMPROVED LONG-TERM OUTCOMES. THE PATIENT CARE CENTER SERVED ALMOST 27,000 PEOPLE IN FY22. METASTATIC BREAST CANCER COLLABORATIVE RESEARCH INITIATIVE KOMEN LAUNCHED THE METASTATIC BREAST CANCER COLLABORATIVE RESEARCH INITIATIVE (MBCCRI) WITH A PILOT PROGRAM AT DUKE UNIVERSITY AND THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL. THE GOAL IS TO CATALYZE AND SUPPORT MULTI-INSTITUTIONAL RESEARCH COLLABORATIONS AND BRING TOGETHER THE BEST AND BRIGHTEST RESEARCHERS AT SELECT INSTITUTIONS TO SHARE IDEAS, EXPERTISE AND RESOURCES. KOMEN WILL SUPPORT RESEARCH GRANT TO FIND BREAKTHROUGH DISCOVERIES TO END METASTATIC BREAST CANCER. |
| Form 990, Part III, Line 4 Program service accomplishments continued | INFLAMMATORY BREAST CANCER COLLABORATIVE FOR THE FIRST TIME, KOMEN IS LEADING TO DRIVE A NEW DIAGNOSTIC DEFINITION OF BREAST CANCER, SPECIFICALLY INFLAMMATORY BREAST CANCER, A DEADLY AND AGGRESSIVE FORM OF CANCER. KOMEN HAS PARTNERED WITH THE INFLAMMATORY BREAST CANCER RESEARCH FOUNDATION AND THE MILBURN FOUNDATION TO CONVENE PATIENT ADVOCATES, BREAST CANCER RESEARCHERS AND CLINICIANS TO REVIEW THE STATE OF IBC CARE AND RESEARCH GLOBALLY AND PROPOSE SPECIFIC INITIATIVES TO MOVE THE FIELD FORWARD. THE OUTCOME OF THE DISCUSSIONS WAS ABUNDANTLY CLEAR: THE FIELD NEEDS A FORMAL DEFINITION OF IBC. WITHOUT A CLEAR DEFINITION, BOTH PATIENT CARE AND RESEARCH SUFFER. DIAGNOSIS REMAINS SUBJECTIVE AND TREATMENT VARIABLE. THE GOAL IS TO MOVE BEYOND THE SUBJECTIVE 'CLINICAL DIAGNOSIS' TO A SET OF SPECIFIC DIAGNOSTIC CRITERIA AND SCORING SYSTEM THAT WILL ADVANCE IBC RESEARCH AND FACILITATE THE DISCOVERIES THAT WILL IMPROVE CARE OF IBC PATIENTS. A PROPOSED DEFINITION OF IBC, BASED ON A REVIEW OF CLINICAL, AND PATHOLOGIC FEATURES WAS SUBMITTED FOR PUBLICATION. BIG DATA FOR BREAST CANCER KOMEN CONTINUES WORK ON THE BIG DATA FOR BREAST CANCER INITIATIVE, WHICH IS AIMED AT USING BIG DATA TO FUEL SCIENTIFIC DISCOVERIES AND ACCELERATE THE DELIVERY OF EQUITABLE, PATIENT-FOCUSED CARE. KOMEN EMPOWERS BREAST CANCER PATIENTS, ADVOCATES AND THE PUBLIC WITH INFORMATION AND TOOLS TO MAKE DATA SHARING UNDERSTANDABLE THROUGH THE BIG DATA FOR BREAST CANCER PATIENTS EDUCATIONAL PROGRAMS. WE ALSO ADDRESS THE CHALLENGES OF INCORPORATING BIG DATA APPLICATIONS INTO BREAST CANCER RESEARCH AND CLINICAL CARE THROUGH WORKING WITH PARTNERS REPRESENTING A VARIETY OF STAKEHOLDERS IN BREAST CANCER RESEARCH. ADDITIONALLY, KOMEN SUPPORTS DATA SCIENCE PROJECTS TO IMPROVE BREAST CANCER OUTCOMES AND SAVE LIVES. PUBLIC POLICY AND ADVOCACY SUSAN G. KOMEN IS THE NONPARTISAN VOICE OF MORE THAN 3.8 MILLION BREAST CANCER SURVIVORS, THOSE LIVING WITH THE DISEASE AND THE PEOPLE WHO LOVE THEM. KOMEN WORKS TO EDUCATE PEOPLE ABOUT PUBLIC POLICY ISSUES, SO THEY ARE EMPOWERED TO BECOME FORCEFUL ADVOCATES FOR THEMSELVES AND THEIR NEIGHBORS, AND THEN UNITES THEIR COLLECTIVE VOICES FOR MAXIMUM IMPACT. THROUGH OUR CENTER FOR PUBLIC POLICY, KOMEN ENSURES THAT OUR POLICYMAKERS ARE EDUCATED ABOUT THE NEEDS OF BREAST CANCER PATIENTS AND PRIORITIZE THE ISSUES IMPACTING THEM. ONLY THROUGH INFORMED GOVERNMENT ACTION CAN WE MAKE THE BROAD, SYSTEMIC AND LASTING CHANGE REQUIRED. KOMEN'S 2021-2022 PUBLIC POLICY AND ADVOCACY PRIORITIES INCLUDED: EXPANDING ACCESS TO AFFORDABLE, HIGH-QUALITY HEALTH CARE FOR ALL PATIENT POPULATIONS; SUPPORTING INCREASED STATE AND FEDERAL FUNDING FOR BREAST CANCER RESEARCH AND INCREASED EDUCATION, UTLIZATION OF AND ACCESS TO CLINICAL TRIALS; SUPPORTING STATE AND FEDERAL FUNDING FOR THE CENTERS FOR DISEASE CONTROL AND PREVENTION'S (CDC) NATIONAL BREAST AND CERVICAL CANCER EARLY DETECTION PROGRAM (NBCCEDP); ADVOCATING FOR STATE AND FEDERAL POLICIES TO IMPROVE INSURANCE COVERAGE OF BREAST CANCER TREATMENTS, INCLUDING THOSE THAT WOULD REQUIRE ORAL PARITY, PRECLUDE SPECIALTY TIERS AND PREVENT STEP THERAPY PROTOCOLS; AND ADVOCATING FOR STATE AND FEDERAL POLICIES TO REDUCE OR ELIMINATE OUT-OF-POCKET COSTS FOR MEDICALLY NECESSARY DIAGNOSTIC IMAGING. IN ADDITION TO THE STATE AND FEDERAL WORK ON OUR PUBLIC POLICY AND ADVOCACY PRIORITIES, KOMEN ALSO ENGAGED ON ISSUES RELATED TO CUSTOM BREAST PROTHESES, GENETIC AND GENOMIC TESTING, LYMPHEDEMA, MEDICARE WAITING PERIODS, PALLIATIVE CARE, SURPRISE MEDICAL BILLING AND SURVIVORSHIP. KOMEN DEVELOPED AND IMPLEMENTED ADVOCACY CAMPAIGNS TO ENCOURAGE LAWMAKERS AND AGENCY OFFICIALS TO SUPPORT AND IMPLEMENT PROGRAMS THAT WOULD ADVANCE OUR PRIORITY ISSUES. KOMEN CONTINUED TO RECRUIT AND ENGAGE ADVOCATES TO FURTHER STRENGTHEN ITS GRASSROOTS ADVOCACY NETWORK. |
| Form 990, Part VI, Line 1a Executive Committee | THE ORGANIZATION'S BYLAWS PROVIDE FOR AN EXECUTIVE COMMITTEE COMPRISED OF A MINIMUM OF FIVE MEMBERS INCLUDING THE BOARD CHAIR, THE PRESIDENT AND CHIEF EXECUTIVE OFFICER, AND ADDITIONAL BOARD MEMBERS, AS RECOMMENDED BY THE GOVERNANCE COMMITTEE AND APPOINTED BY THE BOARD OF DIRECTORS. MEMBERS OF THE EXECUTIVE COMMITTEE MUST EITHER BE DIRECTORS OF THE ORGANIZATION OR THE PRESIDENT AND CHIEF EXECUTIVE OFFICER. THE BYLAWS PROVIDE THE EXECUTIVE COMMITTEE WITH THE AUTHORITY TO: (A) APPOINT MEMBERS TO NON-STANDING COMMITTEES OF THE ORGANIZATION, AND NAME CHAIRS OF SUCH COMMITTEES; (B) AUTHORIZE UNBUDGETED DISBURSEMENTS BY THE ORGANIZATION IN ACCORDANCE WITH THE SPECIFIC EXPENDITURE AUTHORITY PRESCRIBED BY THE BOARD OF DIRECTORS; (C) EMPLOY AGENTS; AND (D) CARRY INTO EXECUTION SUCH OTHER MEASURES AS IT DETERMINES WILL PROMOTE THE PURPOSE OF THE ORGANIZATION. THE COMMITTEE ALSO MAY EXERCISE, WHEN THE BOARD IS NOT IN SESSION, ALL OF THE AUTHORITY OF THE BOARD IN THE MANAGEMENT OF THE BUSINESS AND AFFAIRS OF THE ORGANIZATION WITH CERTAIN EXCEPTIONS SUCH AS REPEALING ANY BOARD RESOLUTIONS, AMENDING THE ORGANIZATION'S ARTICLES OR BYLAWS, OR MERGING OR DISSOLVING THE ORGANIZATION. THIS DELEGATION DOES NOT RELIEVE THE BOARD OF ANY OF ITS RESPONSIBILITIES IMPOSED BY LAW, AND THE COMMITTEE ENDEAVORS TO LIMIT ITS EXERCISE OF AUTHORITY TO TIME SENSITIVE ISSUES. |
| Form 990, Part VI, Line 11b Review of form 990 by governing body | MANAGEMENT PREPARES THE MATERIALS FOR THE FORM 990, WITH THE ASSISTANCE OF AND REVIEW BY EXTERNAL ACCOUNTANTS. SENIOR LEVEL MANAGEMENT REVIEW AND COMMENT ON THE FINAL DRAFT OF THE FORM 990 FOR SUBSEQUENT PRESENTATION TO THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS. THE AUDIT COMMITTEE REVIEWS, MAKES RECOMMENDATIONS, AND APPROVES THE FORM 990 FOR PRESENTATION TO THE BOARD OF DIRECTORS. THEREAFTER, THE BOARD OF DIRECTORS REVIEWS AND APPROVES THE FORM 990 PRIOR TO FILING. |
| Form 990, Part VI, Line 12c Conflict of interest policy | KOMEN'S CONFLICT OF INTEREST POLICY REQUIRES EVERY BOARD MEMBER, OFFICER, COMMITTEE MEMBER, ADVISORY BOARD MEMBER, AND EMPLOYEE TO AVOID CONFLICTS OF INTEREST. IT ALSO REQUIRES THESE PERSONS TO REPORT ANY ACTUAL AND/OR POTENTIAL CONFLICTS OF INTEREST AS SOON AS POSSIBLE. REPORTS ARE REVIEWED BY THE GENERAL COUNSEL'S OFFICE AND/OR AUDIT COMMITTEE, AND APPROPRIATE ACTION IS TAKEN PURSUANT TO THE CONFLICT OF INTEREST POLICY. FURTHER, KOMEN PRODUCES AN ANNUAL SURVEY REQUIRING ALL BOARD MEMBERS, OFFICERS, COMMITTEE MEMBERS, ADVISORY BOARD MEMBERS, AND EMPLOYEES TO REVIEW THE CONFLICT OF INTEREST POLICY AND DISCLOSE ANY ADDITIONAL ACTUAL/POTENTIAL CONFLICTS OF INTEREST. THESE ANNUAL DISCLOSURES ARE REVIEWED IN THE SAME MANNER. THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS RECEIVES, AND REVIEWS ALL REPORTED ACTUAL AND POTENTIAL CONFLICTS OF INTEREST AND THE RELATED ACTION TO ADDRESS THEM. |
| Form 990, Part VI, Line 15a Process to establish compensation of top management official | THE HUMAN CAPITAL MANAGEMENT COMMITTEE OF THE BOARD OF DIRECTORS ASSISTS THE BOARD IN OVERSEEING COMPENSATION POLICIES AND BEST PRACTICES. RESPONSIBILITIES INCLUDE OVERSIGHT OF THE COMPENSATION OF THE CHIEF EXECUTIVE OFFICER; THE RANGE OF COMPENSATION LEVELS FOR THE ORGANIZATION'S OTHER OFFICERS, DISQUALIFIED PERSONS, AND OTHER KEY EMPLOYEES; GRANTING THE CHIEF EXECUTIVE OFFICER WITH THE AUTHORITY TO DETERMINE COMPENSATION LEVELS WITHIN AN APPROVED RANGE; AND ANY INCENTIVE/BONUS COMPENSATION PROGRAMS, IF APPROVED. THE CURRENT POLICY WAS ADOPTED IN 2010 AND IS REVIEWED ANNUALLY. A FORMAL COMPENSATION POLICY GOVERNS PAY PRACTICES. PERIODICALLY, ALL POSITIONS IN THE ORGANIZATION ARE REVIEWED AGAINST EXTERNAL MARKET DATA BY ENGAGING INDEPENDENT EXPERTS OR ACQUIRING UPDATED MARKET DATA TO CONDUCT THE BENCHMARKING PROCESS. COMPENSATION IS THEN BASED UPON COMPARABLE MARKET RATES OF PAY WITH CONSIDERATION FOR INTERNAL EQUITY AND THE FINANCIAL POSITION OF THE ORGANIZATION. BENCHMARKING WAS CONDUCTED FOR THE CHIEF EXECUTIVE OFFICER AND ALL EXECUTIVE TEAM MEMBERS' COMPENSATION TO EXTERNAL MARKET DATA IN 2022, TO ENSURE MARKET ALIGNMENT. KOMEN PROVIDES SALARY INCREASES, PROMOTIONS AND OTHER FORMS OF COMPENSATION WITHOUT REGARD TO RACE, COLOR, RELIGION, GENDER, NATIONAL ORIGIN, DISABILITY, VETERAN STATUS OR SEXUAL ORIENTATION. |
| Form 990, Part VI, Line 15b Process to establish compensation of other employees | THE HUMAN CAPITAL MANAGEMENT COMMITTEE OF THE BOARD OF DIRECTORS ASSISTS THE BOARD IN OVERSEEING COMPENSATION POLICIES AND BEST PRACTICES. RESPONSIBILITIES INCLUDE OVERSIGHT OF THE COMPENSATION OF THE CHIEF EXECUTIVE OFFICER; THE RANGE OF COMPENSATION LEVELS FOR THE ORGANIZATION'S OTHER OFFICERS, DISQUALIFIED PERSONS, AND OTHER KEY EMPLOYEES; GRANTING THE CHIEF EXECUTIVE OFFICER WITH THE AUTHORITY TO DETERMINE COMPENSATION LEVELS WITHIN AN APPROVED RANGE; AND ANY INCENTIVE/BONUS COMPENSATION PROGRAMS, IF APPROVED. THE CURRENT POLICY WAS ADOPTED IN 2010 AND IS REVIEWED ANNUALLY. A FORMAL COMPENSATION POLICY GOVERNS PAY PRACTICES. PERIODICALLY, ALL POSITIONS IN THE ORGANIZATION ARE REVIEWED AGAINST EXTERNAL MARKET DATA BY ENGAGING INDEPENDENT EXPERTS OR ACQUIRING UPDATED MARKET DATA TO CONDUCT THE BENCHMARKING PROCESS. COMPENSATION IS THEN BASED UPON COMPARABLE MARKET RATES OF PAY WITH CONSIDERATION FOR INTERNAL EQUITY AND THE FINANCIAL POSITION OF THE ORGANIZATION. BENCHMARKING WAS CONDUCTED FOR THE CHIEF EXECUTIVE OFFICER AND ALL EXECUTIVE TEAM MEMBERS' COMPENSATION TO EXTERNAL MARKET DATA IN 2022, TO ENSURE MARKET ALIGNMENT. KOMEN PROVIDES SALARY INCREASES, PROMOTIONS AND OTHER FORMS OF COMPENSATION WITHOUT REGARD TO RACE, COLOR, RELIGION, GENDER, NATIONAL ORIGIN, DISABILITY, VETERAN STATUS OR SEXUAL ORIENTATION. |
| Form 990, Part VI, Line 19 Required documents available to the public | KOMEN'S FINANCIAL STATEMENTS AND THE FORM 990 ARE PUBLICLY AVAILABLE ON OUR WEBSITE. THE CERTIFICATE OF FORMATION IS AVAILABLE FROM THE TEXAS SECRETARY OF STATE AND OTHER GOVERNING DOCUMENTS ARE MADE AVAILABLE AS REQUIRED BY STATE LAW. FORM 1023 AND THE CONFLICT OF INTEREST POLICY ARE NOT PUBLISHED ONLINE BUT ARE AVAILABLE TO THE PUBLIC UPON REQUEST. |
| Form 990, Part IX, Line 1 | FOR NEARLY 40 YEARS, SUSAN G. KOMEN HAS WORKED TO FULFILL ITS VISION OF CREATING A WORLD WITHOUT BREAST CANCER THROUGH ITS MISSION OF SAVING LIVES BY MEETING THE MOST CRITICAL NEEDS IN OUR COMMUNITIES AND INVESTING IN BREAKTHROUGH RESEARCH TO BETTER DETECT, PREVENT, TREAT BREAST CANCERS. OVER THE LAST TWO YEARS, KOMEN CONTINUED TO IMPLEMENT A SERIES OF CHANGES BEGUN IN 2020 TO STRENGTHEN ITS FINANCIAL AND OPERATIONAL POSITION IN RESPONSE TO THE CHANGING NEEDS OF THE BREAST CANCER COMMUNITY AND ECONOMIC CONDITIONS RESULTING FROM THE COVID-19 PANDEMIC. KOMEN HAS NEARLY COMPLETED THE CONSOLIDATION OF ALL OPERATIONS OF ITS INDEPENDENT AFFILIATES INTO ITS HEADQUARTERS ORGANIZATION, RESULTING IN A SINGLE ORGANIZATION. THIS CONSOLIDATION IS ENABLING KOMEN TO LEVERAGE THE COMBINED EXPERTISE OF ITS MISSION LEADERS TO DELIVER A UNITED MISSION PROGRAM, UTILIZING TECHNOLOGY AS A KEY DRIVER TO CONNECT TO PEOPLE WHO NEED TO ACCESS CARE WHERE THEY ARE AND TO HELP IMPROVE THE PATIENT EXPERIENCE, AS WELL AS RESULTED IN ADMINISTRATIVE AND OPERATIONAL EFFICIENCIES. CENTRAL TO KOMEN'S VISION IS A STEADFAST COMMITMENT TO INVESTING IN BREAKTHROUGH RESEARCH. KOMEN REMAINED COMMITTED TO INVESTING IN RESEARCH FOCUSED ON ITS PRIMARY FOCUS ON METASTATIC BREAST CANCER AND UNDERSTANDING AND ELIMINATING DISPARITIES IN BREAST CANCER OUTCOMES BETWEEN BLACK AND WHITE PATIENTS. DESPITE THE ECONOMIC UNCERTAINTY AND CHALLENGING FUNDRAISING ENVIRONMENT, KOMEN AWARDED $21 MILLION IN NEW RESEARCH AWARDS. WHILE WE CONTINUE TO INVEST IN RESEARCH INTO NEW TREATMENTS, KOMEN SUPPORTS PEOPLE WHO ARE FACING BREAST CANCER TODAY THROUGH A GROWING SUITE OF PATIENT CARE SERVICES, INCLUDING DIRECT FINANCIAL ASSISTANCE THROUGH ITS TREATMENT ASSISTANCE PROGRAM, ELIGIBLE TO HELP PAY FOR EXPENSES THAT MAY SERVE AS A BARRIER TO ATTAINING THE CARE NEEDED TO SURVIVE, SUCH AS CO-PAYS, TRANSPORTATION, CHILDCARE OR RENT. |
| Form 990, Part XI, Line 9 Other changes in net assets or fund balances | RESCINDED GRANTS - 589946; Event Cost Reclass - 27703; |
| Software ID: | 21014044 |
| Software Version: | 2021v4.2 |