TY 2021 Form 990

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)
(1) JAMES R DOWNING...................................................................... PRESIDENT/CEO	55.00 ................. 1.00	X	X	1,253,079	0	293,293
(2) RICHARD C SHADYAC JR...................................................................... EX-OFFICIO DIRECTOR	1.00 ................. 55.00	X		0	957,998	133,667
(3) JOYCE ABOUSSIE...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(4) PAUL J AYOUB ESQ...................................................................... VOTING DIRECTOR	8.00 ................. 4.00	X		0	0	0
(5) JOSEPH S AYOUB JR ESQ...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(6) FREDERICK M AZAR MD...................................................................... VOTING DIRECTOR	4.00 ................. 8.00	X		0	0	0
(7) MARTHA PERINE BEARD...................................................................... VOTING DIRECTOR	4.00 ................. 8.00	X		0	0	0
(8) SHERYL BOURISK...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(9) ROBERT A BREIT MD...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(10) TERRY L BURMAN...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(11) ANN M DANNER...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(12) JOSEPH M DEVIVO...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(13) FRED P GATTAS III PHARMD...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(14) RUTH GAVIRIA...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(15) JUDY HABIB...................................................................... VOTING DIRECTOR	8.00 ................. 4.00	X		0	0	0
(16) GABRIEL HADDAD MD...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0
(17) CHUCK HAJJAR...................................................................... VOTING DIRECTOR	4.00 ................. 4.00	X		0	0	0

(A) Name and title	(B) Average hours per week (list any hours for related organizations below dotted line)	(C) Position (do not check more than one box, unless person is both an officer and a director/trustee)	(E) Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC)
(18) FOUAD HAJJAR MD........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(19) FREDERICK R HARRIS JR MD........................................................................ VOTING DIRECTOR	8.00 .......................4.00	X			0	0
(20) J DAVID KARAM II........................................................................ VOTING DIRECTOR	4.00 .......................8.00	X			0	0
(21) SHARON L MCCOLLAM........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(22) MICHAEL D MCCOY........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(23) ROBERT T MOLINET ESQ........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(24) RAMZI NUWAYHID........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(25) THOMAS PENN III........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(26) CHRISTINA M RASHID........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(27) CAMILLE F SARROUF JR ESQ........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(28) JOSEPH C SHAKER........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(29) JOSEPH G SHAKER........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(30) MICHAEL SIMON........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(31) GEORGE A SIMON II........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(32) TONY THOMAS........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(33) RICHARD M UNES........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(34) PAUL H WEIN ESQ........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(35) SUSAN R WINDHAM-BANNISTER........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(36) TAMA ZAYDON........................................................................ VOTING DIRECTOR	4.00 .......................4.00	X			0	0
(37) ELLIS NEUFELD........................................................................ EVP/CLINICAL DIRECTOR	55.00 .......................0.00		X		1,280,275	103,039
(38) CHARLES M ROBERTS........................................................................ EVP/DIRECTOR CANCER CENTER	55.00 .......................0.00		X		888,725	178,448
(39) CARLOS RODRIGUEZ-GALINDO........................................................................ EVP/CHAIR	55.00 .......................0.00		X		739,234	152,606
(40) PATRICIA A KEEL........................................................................ EVP, CAO & CFO	55.00 .......................0.00		X		738,998	93,264
(41) JAMES I MORGAN........................................................................ EVP/SCIENTIFIC DIRECTOR (THRU 04/22)	55.00 .......................0.00		X		650,681	60,746
(42) JOSEPH P TAYLOR........................................................................ EVP/SCIENTIFIC DIRECTOR (BEG 04/22)	55.00 .......................0.00		X		150,612	0
(43) DAVID ELLISON........................................................................ CHAIR	55.00 .......................0.00			X	1,865,718	49,437
(44) ZOLTAN PATAY........................................................................ CHAIR	55.00 .......................0.00			X	1,093,857	75,609
(45) THOMAS E MERCHANT........................................................................ CHAIR	55.00 .......................0.00			X	988,716	243,314
(46) RANDALL T HAYDEN........................................................................ FACULTY	55.00 .......................0.00			X	965,395	66,855
(47) ANDREW DAVIDOFF........................................................................ CHAIR	55.00 .......................0.00			X	934,684	188,962

(A) Name and business address	(B) Description of services	(C) Compensation
FLINTCO LLC 2179 HILLSHIRE CIRCLE MEMPHIS,TN38133	CONSTRUCTION CONTRACTOR	37,213,100
IMPACT ADVISORS LLC PO BOX 379 NAPERVILLE,IL605660379	CONSULTING SERVICES	8,320,270
DELL MARKETING LP PO BOX 534118 ATLANTA,GA303534118	SOFTWARE SUPPORT	4,787,068
UT LEBONHEUR PEDIATRIC SPECIALISTS INC PO BOX 27891 BELFAST,ME049152030	MEDICAL SERVICES	3,709,028
BELZ CONSTRUCTION SERVICES LLC 100 PEABODY PLACE STE 1400 MEMPHIS,TN38103	CONSTRUCTION CONTRACTOR	3,100,748
2 Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization 66

- TIN:

SCHEDULE A
(Form 990)

Department of the Treasury
Internal Revenue Service

Public Charity Status and Public Support

Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow

Attach to Form 990 or Form 990-EZ.
right arrow

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Reason for Public Charity Status (All organizations must complete this part.) See instructions.

The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)

A church, convention of churches, or association of churches described in section 170(b)(1)(A)(i).

A school described in section 170(b)(1)(A)(ii). (Attach Schedule E (Form 990).)

A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).

A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name, city, and state:

An organization operated for the benefit of a college or university owned or operated by a governmental unit described in section 170(b)(1)(A)(iv). (Complete Part II.)

A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).

An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in section 170(b)(1)(A)(vi). (Complete Part II.)

A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)

An agricultural research organization described in 170(b)(1)(A)(ix) operated in conjunction with a land-grant college or university or a non-land grant college of agriculture. See instructions. Enter the name, city, and state of the college or university:

An organization that normally receives: (1) more than 33 1/3% of its support from contributions, membership fees, and gross receipts from activities related to its exempt functions—subject to certain exceptions, and (2) no more than 33 1/3% of its support from gross investment income and unrelated business taxable income (less section 511 tax) from businesses acquired by the organization after June 30, 1975. See section 509(a)(2). (Complete Part III.)

An organization organized and operated exclusively to test for public safety. See section 509(a)(4).

An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box on lines 12a through 12d that describes the type of supporting organization and complete lines 12e, 12f, and 12g.

Type I. A supporting organization operated, supervised, or controlled by its supported organization(s), typically by giving the supported organization(s) the power to regularly appoint or elect a majority of the directors or trustees of the supporting organization. You must complete Part IV, Sections A and B.

Type II. A supporting organization supervised or controlled in connection with its supported organization(s), by having control or management of the supporting organization vested in the same persons that control or manage the supported organization(s). You must complete Part IV, Sections A and C.

Type III functionally integrated. A supporting organization operated in connection with, and functionally integrated with, its supported organization(s) (see instructions). You must complete Part IV, Sections A, D, and E.

Type III non-functionally integrated. A supporting organization operated in connection with its supported organization(s) that is not functionally integrated. The organization generally must satisfy a distribution requirement and an attentiveness requirement (see instructions). You must complete Part IV, Sections A and D, and Part V.

Check this box if the organization received a written determination from the IRS that it is a Type I, Type II, Type III functionally integrated, or Type III non-functionally integrated supporting organization.

Enter the number of supported organizations ...............................

Provide the following information about the supported organization(s).

(i) Name of supported organization	(ii) EIN	(iv) Is the organization listed in your governing document?		(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)
(i) Name of supported organization	(ii) EIN	Yes	No	(v) Amount of monetary support (see instructions)	(vi) Amount of other support (see instructions)


Total

For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.

Cat. No. 11285F

Schedule A (Form 990) 2021

Page 2

Part II

Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") ..	851,803,301	974,758,247	1,094,131,374	1,130,870,648	1,236,970,064	5,288,533,634
2	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....
3	The value of services or facilities furnished by a governmental unit to the organization without charge..
4	Total. Add lines 1 through 3	851,803,301	974,758,247	1,094,131,374	1,130,870,648	1,236,970,064	5,288,533,634
5	The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) ..
6	Public support. Subtract line 5 from line 4.						5,288,533,634

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
7	Amounts from line 4..	851,803,301	974,758,247	1,094,131,374	1,130,870,648	1,236,970,064	5,288,533,634
8	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources...	11,308,521	14,733,405	9,206,868	7,628,043	22,090,006	64,966,843
9	Net income from unrelated business activities, whether or not the business is regularly carried on..
10	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.)..	7,598,809	9,873,680	9,142,582	6,485,751	8,793,618	41,894,440
11	Total support. Add lines 7 through 10						5,395,394,917

Gross receipts from related activities, etc. (see instructions) ..................

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here ........................................ right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 6, column (f) divided by line 11, column (f)) .........

98.020 %

Public support percentage for 2020 Schedule A, Part II, line 14 ...............

97.950 %

16a

33 1/3% support test—2021. If the organization did not check the box on line 13, and line 14 is 33 1/3 % or more, check this box
and stop here. The organization qualifies as a publicly supported organization ....................... right arrow

33 1/3% support test—2020. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow

17a

10%-facts-and-circumstances test—2021. If the organization did not check a box on line 13, 16a, or 16b, and line 14
is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain
in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported
organization ..................................................... right arrow

10%-facts-and-circumstances test—2020. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line
15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here.
Explain in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly
supported organization ................................................ right arrow

Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow

Schedule A (Form 990) 2021

Page 3

Part III

Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)

Section A. Public Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
1	Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .
2	Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose
3	Gross receipts from activities that are not an unrelated trade or business under section 513 .....
4	Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...
5	The value of services or facilities furnished by a governmental unit to the organization without charge
6	Total. Add lines 1 through 5
7a	Amounts included on lines 1, 2, and 3 received from disqualified persons
b	Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.
c	Add lines 7a and 7b..
8	Public support. (Subtract line 7c from line 6.)

Section B. Total Support

Calendar year (or fiscal year beginning in)		(a) 2017	(b) 2018	(c) 2019	(d) 2020	(e) 2021	(f) Total
9	Amounts from line 6...
10a	Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..
b	Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.
c	Add lines 10a and 10b.
11	Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on.
12	Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..
13	Total support. (Add lines 9, 10c, 11, and 12.)..

First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,
check this box and stop here............................................. right arrow

Section C. Computation of Public Support Percentage

Public support percentage for 2021 (line 8, column (f) divided by line 13, column (f)) .........

Public support percentage from 2020 Schedule A, Part III, line 15 ...............

Section D. Computation of Investment Income Percentage

Investment income percentage for 2021 (line 10c, column (f) divided by line 13, column (f)) ......

Investment income percentage from 2020 Schedule A, Part III, line 17 .............

19a

331/3% support tests—2021. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ....... right arrow

33 1/3% support tests—2020. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization .... right arrow

Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions .... right arrow

Schedule A (Form 990) 2021

Page 4

Part IV

Supporting Organizations

(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, of Part I, complete Sections A and B. If you checked box 12b, of Part I, complete Sections A and C. If you checked box 12c, of Part I, complete Sections A, D, and E. If you checked box12d, of Part I, complete Sections A and D, and complete Part V.)

Section A. All Supporting Organizations

Yes

Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.

Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).

Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer lines 3b and 3c below.

Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.

Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.

Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below.

Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.

Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.

Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).

Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?

Substitutions only. Was the substitution the result of an event beyond the organization's control?

Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.

Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990) .

Did the organization make a loan to a disqualified person (as defined in section 4958) not described on line 7? If “Yes,” complete Part I of Schedule L (Form 990).

Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons, as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.

Did one or more disqualified persons (as defined on line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.

Did a disqualified person (as defined on line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.

10a

Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.

10a

Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).

10b

Schedule A (Form 990) 2021

Page 5

Part IV

Supporting Organizations (continued)

Yes

Has the organization accepted a gift or contribution from any of the following persons?

A person who directly or indirectly controls, either alone or together with persons described on lines 11b and 11c below, the governing body of a supported organization?

11a

A family member of a person described on 11a above?

11b

A 35% controlled entity of a person described on line 11a or 11b above? If “Yes” to 11a, 11b, or 11c, provide detail in Part VI.

11c

Section B. Type I Supporting Organizations

Yes

Did the officers, directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.

Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.

Section C. Type II Supporting Organizations

Yes

Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).

Section D. All Type III Supporting Organizations

Yes

Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?

Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).

By reason of the relationship described in line 2 above, did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.

Section E. Type III Functionally-Integrated Supporting Organizations

Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):

The organization satisfied the Activities Test. Complete line 2 below.

The organization is the parent of each of its supported organizations. Complete line 3 below.

The organization supported a governmental entity. Describe in Part VI how you supported a government entity (see instructions)

Activities Test. Answer lines 2a and 2b below.

Yes

Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.

Did the activities described on line 2a, above constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.

Parent of Supported Organizations. Answer lines 3a and 3b below.

Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations?If "Yes" or "No", provide details in Part VI.

Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.

Schedule A (Form 990) 2021

Page 6

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations

Check here if the organization satisfied the Integral Part Test as a qualifying trust on Nov. 20, 1970 (explain in Part VI). See instructions. All other Type III non-functionally integrated supporting organizations must complete Sections A through E.

	Section A - Adjusted Net Income		(A) Prior Year	(B) Current Year (optional)
1	Net short-term capital gain	1
2	Recoveries of prior-year distributions	2
3	Other gross income (see instructions)	3
4	Add lines 1 through 3	4
5	Depreciation and depletion	5
6	Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions)	6
7	Other expenses (see instructions)	7
8	Adjusted Net Income (subtract lines 5, 6 and 7 from line 4)	8

	Section B - Minimum Asset Amount		(A) Prior Year	(B) Current Year (optional)
1	Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year):	1
a	Average monthly value of securities	1a
b	Average monthly cash balances	1b
c	Fair market value of other non-exempt-use assets	1c
d	Total (add lines 1a, 1b, and 1c)	1d
e	Discount claimed for blockage or other factors (explain in detail in Part VI):
2	Acquisition indebtedness applicable to non-exempt use assets	2
3	Subtract line 2 from line 1d	3
4	Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions).	4
5	Net value of non-exempt-use assets (subtract line 4 from line 3)	5
6	Multiply line 5 by 0.035	6
7	Recoveries of prior-year distributions	7
8	Minimum Asset Amount (add line 7 to line 6)	8

	Section C - Distributable Amount		Current Year
1	Adjusted net income for prior year (from Section A, line 8, Column A)	1
2	Enter 85% of line 1	2
3	Minimum asset amount for prior year (from Section B, line 8, Column A)	3
4	Enter greater of line 2 or line 3	4
5	Income tax imposed in prior year	5
6	Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions)	6

Check here if the current year is the organization's first as a non-functionally-integrated Type III supporting organization (see instructions)

Schedule A (Form 990) 2021

Page 7

Part V

Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)

Section D - Distributions		Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes	1
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity	2
3 Administrative expenses paid to accomplish exempt purposes of supported organizations	3
4 Amounts paid to acquire exempt-use assets	4
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI)	5
6 Other distributions (describe in Part VI). See instructions	6
7Total annual distributions. Add lines 1 through 6.	7
8 Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions	8
9 Distributable amount for 2021 from Section C, line 6	9
10 Line 8 amount divided by Line 9 amount	10

Section E - Distribution Allocations (see instructions)		(i) Excess Distributions	(ii) Underdistributions Pre-2021	(iii) Distributable Amount for 2021
1 Distributable amount for 2021 from Section C, line 6
2 Underdistributions, if any, for years prior to 2021 (reasonable cause required-- explain in Part VI). See instructions.
3 Excess distributions carryover, if any, to 2021:
a From 2016.......
b From 2017.......
c From 2018.......
d From 2019.......
e From 2020.......
fTotal of lines 3a through e
g Applied to underdistributions of prior years
h Applied to 2021 distributable amount
i Carryover from 2016 not applied (see instructions)
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.
4Distributions for 2021 from Section D, line 7:
$
a Applied to underdistributions of prior years
b Applied to 2021 distributable amount
c Remainder. Subtract lines 4a and 4b from line 4.
5 Remaining underdistributions for years prior to 2021, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions.
6 Remaining underdistributions for 2021. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions.
7 Excess distributions carryover to 2022. Add lines 3j and 4c.
8 Breakdown of line 7:
a Excess from 2017.....
b Excess from 2018.....
c Excess from 2019.....
d Excess from 2020.....
e Excess from 2021.....

Schedule A (Form 990) (2021)

Schedule A (Form 990) 2021

Page 8

Part VI

Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).

Facts And Circumstances Test

Return Reference	Explanation
PART II, SECTION B, LINE 10:	EXPLANATION FOR OTHER INCOME: 2017 $ 4,288,072 - CAFETERIA/VENDING $ 2,351,842 - CHGME/CHCA $ 327,751 - HHMI $ 631,144 - OTHER REVENUE $ 7,598,809 - TOTAL OTHER INCOME 2018 $ 4,454,476 - CAFETERIA/VENDING $ 2,344,673 - CHGME/CHCA $ 363,869 - HHMI $ 2,710,662 - OTHER REVENUE $ 9,873,680 - TOTAL OTHER INCOME 2019 $ 3,706,979 - CAFETERIA/VENDING $ 2,511,652 - CHGME/CHCA $ 314,924 - HHMI $ 2,609,027 - OTHER REVENUE $ 9,142,582 - TOTAL OTHER INCOME 2020 $ 1,852,003 - CAFETERIA/VENDING $ 2,513,042 - CHGME/CHCA $ 196,501 - HHMI $ 1,924,205 - OTHER REVENUE $ 6,485,751 - TOTAL OTHER INCOME 2021 $ 3,073,670 - CAFETERIA/VENDING $ 2,811,538 - CHGME/CHCA $ 173,725 - HHMI $ 2,734,685 - OTHER REVENUE $ 8,793,618 - TOTAL OTHER INCOME

Return Reference

Explanation

PART II, SECTION B, LINE 10:

EXPLANATION FOR OTHER INCOME: 2017 $ 4,288,072 - CAFETERIA/VENDING $ 2,351,842 - CHGME/CHCA $ 327,751 - HHMI $ 631,144 - OTHER REVENUE $ 7,598,809 - TOTAL OTHER INCOME 2018 $ 4,454,476 - CAFETERIA/VENDING $ 2,344,673 - CHGME/CHCA $ 363,869 - HHMI $ 2,710,662 - OTHER REVENUE $ 9,873,680 - TOTAL OTHER INCOME 2019 $ 3,706,979 - CAFETERIA/VENDING $ 2,511,652 - CHGME/CHCA $ 314,924 - HHMI $ 2,609,027 - OTHER REVENUE $ 9,142,582 - TOTAL OTHER INCOME 2020 $ 1,852,003 - CAFETERIA/VENDING $ 2,513,042 - CHGME/CHCA $ 196,501 - HHMI $ 1,924,205 - OTHER REVENUE $ 6,485,751 - TOTAL OTHER INCOME 2021 $ 3,073,670 - CAFETERIA/VENDING $ 2,811,538 - CHGME/CHCA $ 173,725 - HHMI $ 2,734,685 - OTHER REVENUE $ 8,793,618 - TOTAL OTHER INCOME

Schedule A (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

Schedule B
(Form 990)

Department of the Treasury
Internal Revenue Service

Schedule of Contributors

Attach to Form 990, 990-EZ, or 990-PF.

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Organization type (check one):

Filers of:

Section:

Form 990 or 990-EZ

501(c)( ) (enter number) organization

4947(a)(1) nonexempt charitable trust not treated as a private foundation

527 political organization

Form 990-PF

501(c)(3) exempt private foundation

4947(a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule.
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.

General Rule

For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, contributions totaling $5,000 or more (in money or other property) from any one contributor. Complete Parts I and II. See instructions for determining a contributor's total contributions.

Special Rules

For an organization described in section 501(c)(3) filing Form 990 or 990-EZ that met the 33¹/3% support test of the regulations
under sections 509(a)(1) and 170(b)(1)(A)(vi), that checked Schedule A (Form 990 or 990-EZ), Part II, line 13, 16a, or 16b, and that received from any one contributor, during the year, total contributions of the greater of (1) $5,000 or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h, or (ii) Form 990-EZ, line 1. Complete Parts I and II.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, total contributions of more than $1,000 exclusively for religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals. Complete Parts I, II, and III.

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor,
during the year, contributions exclusively for religious, charitable, etc., purposes, but no such contributions totaled more than $1,000. If this box is checked, enter here the total contributions that were received during the year for an exclusively religious, charitable, etc., purpose. Don't complete any of the parts unless the General Rule applies to this organization because it received nonexclusively religious, charitable, etc., contributions totaling $5,000 or more during the year ......... Arrow Bullet

Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).

For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.

Cat. No. 30613XSchedule B (Form 990) (2021)

Schedule B (Form 990) (2021) Page 2

Name of organization ST JUDE CHILDREN'S RESEARCH HOSPITAL INC

Part I Contributors	Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
RESTRICTED	,	$ RESTRICTED	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
(a) No.	(b) Name, address, and ZIP + 4	(c) Total contributions	(d) Type of contribution
		$	Person Payroll Noncash (Complete Part II for noncash contributions.)
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 3

Name of organization ST JUDE CHILDREN'S RESEARCH HOSPITAL INC		Employer identification number 62-0646012

Part II	Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
(a) No. from Part I	(b) Description of noncash property given	(c) FMV (or estimate) (See instructions)	(d) Date received
		$
Schedule B (Form 990) (2021)

Schedule B (Form 990) (2021)

Page 4


Name of organization ST JUDE CHILDREN'S RESEARCH HOSPITAL INC			Employer identification number 62-0646012
Part III Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) $ Use duplicate copies of Part III if additional space is needed.

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

(a)
No. from Part I

(b) Purpose of gift

(d) Description of how gift is held

(e) Transfer of gift
Transferee's name, address, and ZIP 4	Relationship of transferor to transferee

Schedule B (Form 990) (2021)

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE C
(Form 990)

Department of the Treasury
Internal Revenue Service

Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527

SchCMd Bullet

Complete if the organization is described below. SchCMd Bullet

Attach to Form 990 or Form 990-EZ.
SchCMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet

Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet

Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet

Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet

Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet

Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet

Section 501(c)(4), (5), or (6) organizations: Complete Part III.

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I-A

Complete if the organization is exempt under section 501(c) or is a section 527 organization.

Provide a description of the organization’s direct and indirect political campaign activities in Part IV. See instructions for definition of “political campaign activities."

Political campaign activity expenditures. See instructions .................................................................... SchCMd Bullet

Volunteer hours for political campaign activities. See instructions ..................................................................

Part I-B

Complete if the organization is exempt under section 501(c)(3).

Enter the amount of any excise tax incurred by the organization under section 4955 ................................ SchCMd Bullet

Enter the amount of any excise tax incurred by organization managers under section 4955 ....................... SchCMd Bullet

If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................

Yes No

Was a correction made? ......................................................................................................................

Yes No

If "Yes," describe in Part IV.

Part I-C

Complete if the organization is exempt under section 501(c), except section 501(c)(3).

Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet

Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................ SchCMd Bullet

Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b........... SchCMd Bullet

Did the filing organization file Form 1120-POL for this year? ...................................................................

Yes No

Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.

(a) Name	(b) Address	(c) EIN	(d) Amount paid from filing organization's funds. If none, enter -0-.	(e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6

For Paperwork Reduction Act Notice, see the instructions for Form 990.

Cat. No. 50084S

Schedule C (Form 990) 2021

Page 2

Part II-A

Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).

A Check SchCMd Bullet

if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN, expenses, and share of excess lobbying expenditures).
B Check SchCMd Bullet

if the filing organization checked box A and "limited control" provisions apply.

Limits on Lobbying Expenditures (The term "expenditures" means amounts paid or incurred.)		(b) Affiliated group totals
1a	Total lobbying expenditures to influence public opinion (grass roots lobbying) ......................
b	Total lobbying expenditures to influence a legislative body (direct lobbying) ........................
c	Total lobbying expenditures (add lines 1a and 1b) ............................................................
d	Other exempt purpose expenditures ...............................................................................
e	Total exempt purpose expenditures (add lines 1c and 1d) ..................................................
f	Lobbying nontaxable amount. Enter the amount from the following table in both columns.
	If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
	Not over $500,00020% of the amount on line 1e.
	Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
	Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
	Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
	Over $17,000,000$1,000,000.

g	Grassroots nontaxable amount (enter 25% of line 1f) .................................................
h	Subtract line 1g from line 1a. If zero or less, enter -0-. ................................................
i	Subtract line 1f from line 1c. If zero or less, enter -0-. ................................................
j	If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting section 4911 tax for this year? ...................................................................................................................	Yes No

4-Year Averaging Period Under Section 501(h) (Some organizations that made a section 501(h) election do not have to complete all of the five columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
	Calendar year (or fiscal year beginning in)	(a) 2018	(b) 2019	(c) 2020	(d) 2021	(e) Total

2a	Lobbying nontaxable amount

b	Lobbying ceiling amount (150% of line 2a, column(e))

c	Total lobbying expenditures

d	Grassroots nontaxable amount

e	Grassroots ceiling amount (150% of line 2d, column (e))

f	Grassroots lobbying expenditures

Schedule C (Form 990) 2021

Page 3

Part II-B

Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).

For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.

(a)

Yes|No

(b)

Amount

During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:

Volunteers? ...........................................................................................................

Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........

Yes

Media advertisements? ...................................................................................................

Mailings to members, legislators, or the public? .............................................................................

Publications, or published or broadcast statements? ...........................................................

Grants to other organizations for lobbying purposes? ..........................................................

Yes

7,200

Direct contact with legislators, their staffs, government officials, or a legislative body? .......................

Yes

21,351

Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................

Other activities? ...................................................................................................................

Yes

62,824

Total. Add lines 1c through 1i ....................................................................................................

91,375

Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....

If "Yes," enter the amount of any tax incurred under section 4912 ...........................................

If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................

If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................

Part III-A

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).

Yes

Were substantially all (90% or more) dues received nondeductible by members? ...............................................

Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................

Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................

Part III-B

Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."

Dues, assessments and similar amounts from members ......................................................................

Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).

Current year .............................................................................................................................

Carryover from last year ............................................................................................................

Total ...........................................................................................................................................

Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .

If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................

Taxable amount of lobbying and political expenditures. See Instructions .........................................

Part IV

Supplemental Information

Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.

Return Reference	Explanation
PART II-B, LINE 1:	LINE 1B) ST. JUDE EMPLOYS A DIRECTOR OF GOVERNMENT AFFAIRS; LINE 1F) AMOUNT LISTED IS CONTRIBUTION TO THE CHGME ADVOCACY CAMPAIGN; LINE 1G) AMOUNT LISTED IS PRORATED SALARY OF DIRECTOR OF GOVERNMENT AFFAIRS PLUS TRAVEL EXPENSES; LINE 1I) AMOUNT LISTED IS RELATED TO PRORATED RETAINER FEES FOR DIRECT FEDERAL AND STATE LEGISLATIVE CONTACTS AS WELL AS PROFESSIONAL DUES ATTRIBUTABLE TO LOBBYING FOR THE CHGME ADVOCACY PROGRAM.

Return Reference

Explanation

PART II-B, LINE 1:

LINE 1B) ST. JUDE EMPLOYS A DIRECTOR OF GOVERNMENT AFFAIRS; LINE 1F) AMOUNT LISTED IS CONTRIBUTION TO THE CHGME ADVOCACY CAMPAIGN; LINE 1G) AMOUNT LISTED IS PRORATED SALARY OF DIRECTOR OF GOVERNMENT AFFAIRS PLUS TRAVEL EXPENSES; LINE 1I) AMOUNT LISTED IS RELATED TO PRORATED RETAINER FEES FOR DIRECT FEDERAL AND STATE LEGISLATIVE CONTACTS AS WELL AS PROFESSIONAL DUES ATTRIBUTABLE TO LOBBYING FOR THE CHGME ADVOCACY PROGRAM.

Schedule C (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE D
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Financial Statements

Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet

Attach to Form 990.
SchDMd Bullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.

		(a) Donor advised funds	(b) Funds and other accounts
1	Total number at end of year .........
2	Aggregate value of contributions to (during year)
3	Aggregate value of grants from (during year)
4	Aggregate value at end of year ........

Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............

Yes No

Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................

Yes No

Part II

Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.

Purpose(s) of conservation easements held by the organization (check all that apply).

Preservation of land for public use (e.g., recreation or education) Preservation of an historically important land area

Protection of natural habitat Preservation of a certified historic structure

Preservation of open space

Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.


a	Total number of conservation easements ......................	2a
b	Total acreage restricted by conservation easements ....................	2b
c	Number of conservation easements on a certified historic structure included in (a) .....	2c
d	Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ...	2d

Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet

Number of states where property subject to conservation easement is located SchDMd Bullet

Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............

Yes No

Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet

Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................

Yes No

In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.

If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.

If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:

(i)

Revenue included on Form 990, Part VIII, line 1 ......................... SchDMd Bullet

(ii)

Assets included in Form 990, Part X ............................... SchDMd Bullet

If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:

Revenue included on Form 990, Part VIII, line 1 .......................... SchDMd Bullet

Assets included in Form 990, Part X ............................... SchDMd Bullet

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 52283D

Schedule D (Form 990) 2021

Page 2

Part III

Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)

Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):

Public exhibition

Loan or exchange programs

Scholarly research

Other

Preservation for future generations

Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.

During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...

Yes No

Part IV

Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.

Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................

Yes No


b	If "Yes," explain the arrangement in Part XIII and complete the following table:		Amount
c	Beginning balance .............................	1c
d	Additions during the year ............................	1d
e	Distributions during the year ..........................	1e
f	Ending balance ................................	1f

Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...

Yes No

If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....

Part V

Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.

		(a) Current year	(b) Prior year	(c) Two years back	(d) Three years back	(e) Four years back

1a	Beginning of year balance ....	1,329,927,343	1,033,682,990	1,055,350,944	1,024,698,330	965,253,422
b	Contributions ...	9,150,000	7,863,768	5,491,426	4,864,242	21,281,957
c	Net investment earnings, gains, and losses	-59,754,448	357,550,674	34,726,892	64,664,085	92,690,065
d	Grants or scholarships ...
e	Other expenditures for facilities and programs ...	69,772,121	69,170,089	61,886,272	38,875,713	54,527,114
f	Administrative expenses ....
g	End of year balance ......	1,209,550,774	1,329,927,343	1,033,682,990	1,055,350,944	1,024,698,330

Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:

Board designated or quasi-endowment SchDMd Bullet

8.200 %

Permanent endowment SchDMd Bullet

91.800 %

Term endowment SchDMd Bullet

The percentages on lines 2a, 2b, and 2c should equal 100%.

Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes

(i) Unrelated organizations .................

3a(i)

Yes

(ii) Related organizations .................

3a(ii)

Yes

If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........

Yes

Describe in Part XIII the intended uses of the organization's endowment funds.

Part VI

Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.

Description of property		(a) Cost or other basis (investment)	(b) Cost or other basis (other)	(c) Accumulated depreciation	(d) Book value

1a	Land .....
b	Buildings ....	1,579,088,779	751,339,856	827,748,923
c	Leasehold improvements
d	Equipment ....	646,832,465	414,549,411	232,283,054
e	Other .....	19,891,376	10,808,743	9,082,633
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..				1,069,114,610

Schedule D (Form 990) 2021

Page 3

Part VII

Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.

(a) Description of security or category (including name of security)	(b) Book value	(c) Method of valuation: Cost or end-of-year market value
(1) Financial derivatives.........
(2) Closely-held equity interests........
(3)Other
(A)
(B)
(C)
(D)
(E)
(F)
(G)
(H)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)

Part VIII

Investments - Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.

(a) Description of investment	(b) Book value	(c) Method of valuation: Cost or end-of-year market value

(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)

Part IX

Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.

(a) Description				(b) Book value
(1)INTEREST IN NET ASSETS OF AMERICAN LEBANESE SYRIAN ASSOCIATED CHARITIES, INC				8,234,654,182
(2)OTHER ASSETS				30,930,687
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........				8,265,584,869

Part X

Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.

1.(a) Description of liability	(b) Book value
(1) Federal income taxes
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)	10,136,180
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII

Schedule D (Form 990) 2021

Page 4

Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total revenue, gains, and other support per audited financial statements .......			1	612,994,613
2	Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a	Net unrealized gains (losses) on investments ....	2a	-185,237
b	Donated services and use of facilities .........	2b
c	Recoveries of prior year grants ...........	2c
d	Other (Describe in Part XIII.) ............	2d	311,260,428
e	Add lines 2a through 2d .....................			2e	311,075,191
3	Subtract line 2e from line 1..................			3	301,919,422
4	Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b .	4a
b	Other (Describe in Part XIII.) ...........	4b	1,083,764,954
c	Add lines 4a and 4b....................			4c	1,083,764,954
5	Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ......			5	1,385,684,376

Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1	Total expenses and losses per audited financial statements ...........		1	1,278,569,778
2	Amounts included on line 1 but not on Form 990, Part IX, line 25:
a	Donated services and use of facilities .........	2a
b	Prior year adjustments ............	2b
c	Other losses ................	2c
d	Other (Describe in Part XIII.) ............	2d
e	Add lines 2a through 2d....................		2e	0
3	Subtract line 2e from line 1...................		3	1,278,569,778
4	Amounts included on Form 990, Part IX, line 25, but not on line 1:
a	Investment expenses not included on Form 990, Part VIII, line 7b ..	4a
b	Other (Describe in Part XIII.) ............	4b
c	Add lines 4a and 4b.....................		4c	0
5	Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ......		5	1,278,569,778

Part XIII

Supplemental Information

Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.

Return Reference	Explanation
PART V, LINE 4:	THE ENDOWMENT FUNDS ARE HELD BY AMERICAN LEBANESE SYRIAN ASSOCIATED CHARITIES, INC., A RELATED ORGANIZATION, AND ARE USED TO SUPPORT THE FUTURE NEEDS OF ST. JUDE.
PART X, LINE 2:	AS OF JUNE 30, 2022, THE ORGANIZATION HAD NOT IDENTIFIED ANY UNCERTAIN TAX POSITIONS UNDER ASC TOPIC 740, INCOME TAXES, REQUIRING ADJUSTMENTS TO ITS COMBINED FINANCIAL STATEMENTS. IN THE EVENT THE ORGANIZATION WERE TO RECOGNIZE INTEREST AND PENALTIES RELATED TO UNCERTAIN TAX POSITIONS, IT WOULD BE RECOGNIZED IN THE COMBINED FINANCIAL STATEMENTS AS A GENERAL EXPENSE. GENERALLY, TAX YEARS ENDING 2018 THROUGH 2022 ARE OPEN TO EXAMINATION BY THE FEDERAL AND STATE TAXING AUTHORITIES, RESPECTIVELY. THERE ARE NO INCOME TAX EXAMINATIONS CURRENTLY IN PROCESS.
PART XI, LINE 2D - OTHER ADJUSTMENTS:	CHANGE IN INTEREST IN NET ASSETS OF ALSAC WITHOUT DONOR RESTRICTIONS 311,260,428.
PART XI, LINE 4B - OTHER ADJUSTMENTS:	CONTRIBUTION - SUPPORT RECEIVED FROM ALSAC 1,083,764,954.

Schedule D (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE F(Form 990)

Department of the Treasury
Internal Revenue Service

Statement of Activities Outside the United States

Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16. Right pointing arrow large image

Attach to Form 990. Right pointing arrow large image

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization
ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.

For grantmakers. Does the organization maintain records to substantiate the amount of its grants and

other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used

to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .

Yes

For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.

Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)

(a) Region		(b) Number of offices in the region	(c) Number of employees, agents, and independent contractors in the region	(d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region)	(e) If activity listed in (d) is a program service, describe specific type of service(s) in the region	(f) Total expenditures for and investments in the region
	CENTRAL AMERICA AND THE CARIBBEAN	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	1,692,300
	EAST ASIA AND THE PACIFIC	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	4,550,798
	EUROPE (INCLUDING ICELAND & GREENLAND)	0	1	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	4,757,017
	MIDDLE EAST AND NORTH AFRICA	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	4,916,389
	NORTH AMERICA	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	1,704,421
	RUSSIA AND NEIGHBORING STATES	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	919,076
	SOUTH AMERICA	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	1,639,992
	SOUTH ASIA	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	4,023
	SUB-SAHARAN AFRICA	0	0	PROGRAM SERVICES	RESEARCH / EDUCATION AND TRAINING	253,087
	EAST ASIA AND THE PACIFIC	0	0	GRANTMAKING		5,440
	RUSSIA AND NEIGHBORING STATES	0	0	GRANTMAKING		764,110
	EUROPE (INCLUDING ICELAND & GREENLAND)	0	0	GRANTMAKING		300,000





3a	Sub-total ....	0	1			20,184,016
b	Total from continuation sheets to Part I ...	0	0			1,322,637
c	Totals (add lines 3a and 3b)	0	1			21,506,653

For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2021

Schedule F (Form 990) 2021

Page 2

Part II

Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.

(c) Region	(d) Purpose of grant	(e) Amount of cash grant	(f) Manner of cash disbursement	(g) Amount of noncash assistance
EAST ASIA AND THE PACIFIC	SPONSORSHIP	5,440	ELECTRONIC FUND/WIRE TRANSFER	0
RUSSIA AND NEIGHBORING STATES	FINANCIAL SUPPORT	214,110	ELECTRONIC FUND/WIRE TRANSFER	0
EUROPE (INCLUDING ICELAND & GREENLAND)	FINANCIAL SUPPORT	300,000	ELECTRONIC FUND/WIRE TRANSFER	0
RUSSIA AND NEIGHBORING STATES	FINANCIAL SUPPORT	550,000	ELECTRONIC FUND/WIRE TRANSFER	0

2	Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......	4
3	Enter total number of other organizations or entities .......................	0

Schedule F (Form 990) 2021

Schedule F (Form 990) 2021Page 3

Part III

Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.

Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance		(b) Region	(c) Number of recipients	(d) Amount of cash grant	(e) Manner of cash disbursement	(f) Amount of noncash assistance	(g) Description of noncash assistance	(h) Method of valuation (book, FMV, appraisal, other)

Schedule F (Form 990) 2021

Page 4

Part IV

Foreign Forms

Schedule F (Form 990) 2021

Page 5

Part V

Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.

ReturnReference	Explanation
PART I, LINE 2:	ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS ACTIVELY INVOLVED WITH THE DONEE. THROUGH THIS ACTIVE INVOLVEMENT, THE ORGANIZATIONS ARE MONITORED TO ENSURE THE SUPPORT IS USED APPROPRIATELY.
PART I, LINE 3:	EXPENDITURES ARE RECORDED ON AN ACCRUAL BASIS. PAYMENTS ARE ISSUED BASED ON CONTRACTUAL OBLIGATIONS UPON RECEIPT OF SUPPORTING DOCUMENTATION.
PART III ACCOUNTING METHOD:

Schedule F (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE H
(Form 990)

Department of the Treasury
Internal Revenue Service

Hospitals

Complete if the organization answered "Yes" on Form 990, Part IV, question 20.
MediumBullet

Attach to Form 990.
MediumBullet

Go to www.irs.gov/Form990EZ for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Financial Assistance and Certain Other Community Benefits at Cost

Yes

Did the organization have a financial assistance policy during the tax year? If "No," skip to question 6a . . . .

Yes

If "Yes," was it a written policy? ......................

Yes

If the organization had multiple hospital facilities, indicate which of the following best describes application of the financial assistance policy to its various hospital facilities during the tax year.

Applied uniformly to all hospital facilities Applied uniformly to most hospital facilities Generally tailored to individual hospital facilities

Answer the following based on the financial assistance eligibility criteria that applied to the largest number of the organization's patients during the tax year.

Did the organization use Federal Poverty Guidelines (FPG) as a factor in determining eligibility for providing free care?

If "Yes," indicate which of the following was the FPG family income limit for eligibility for free care:

100% 150% 200% Other %

Did the organization use FPG as a factor in determining eligibility for providing discounted care? If "Yes," indicate

which of the following was the family income limit for eligibility for discounted care: . . . . . . . .

200% 250% 300% 350% 400% Other %

If the organization used factors other than FPG in determining eligibility, describe in Part VI the criteria used for determining eligibility for free or discounted care. Include in the description whether the organization used an asset test or other threshold, regardless of income, as a factor in determining eligibility for free or discounted care.

Did the organization's financial assistance policy that applied to the largest number of its patients during the tax year provide for free or discounted care to the "medically indigent"? . . . . . . . . . . . . .

Yes

Did the organization budget amounts for free or discounted care provided under its financial assistance policy during
the tax year? . . . . . . . . . . . . . . . . . . . . . . .

Yes

If "Yes," did the organization's financial assistance expenses exceed the budgeted amount? . . . . . .

Yes

If "Yes" to line 5b, as a result of budget considerations, was the organization unable to provide free or discountedcare to a patient who was eligibile for free or discounted care? . . . . . . . . . . . . .

Did the organization prepare a community benefit report during the tax year? . . . . . . . . .

If "Yes," did the organization make it available to the public? . . . . . . . . . . . . .

Complete the following table using the worksheets provided in the Schedule H instructions. Do not submit these worksheets with the Schedule H.

Financial Assistance and Certain Other Community Benefits at Cost

Financial Assistance and Means-Tested Government Programs		(c) Total community benefit expense	(d) Direct offsetting revenue	(e) Net community benefit expense	(f) Percent of total expense
a	Financial Assistance at cost (from Worksheet 1) . . .	64,545,025	265,319	64,279,706	5.030 %
b	Medicaid (from Worksheet 3, column a) . . . . .	194,801,182	47,072,451	147,728,731	11.550 %
c	Costs of other means-tested government programs (from Worksheet 3, column b) . .	10,868,808	2,469,616	8,399,192	0.660 %
d	Total Financial Assistance and Means-Tested Government Programs . . . . .	270,215,015	49,807,386	220,407,629	17.240 %
Other Benefits
e	Community health improvement services and community benefit operations (from Worksheet 4).	40,739,933		40,739,933	3.190 %
f	Health professions education (from Worksheet 5) . . .	23,763,334	262,607	23,500,727	1.840 %
g	Subsidized health services (from Worksheet 6) . . . .	23,921,040		23,921,040	1.870 %
h	Research (from Worksheet 7) .	506,448,295	85,116,479	421,331,816	32.950 %
i	Cash and in-kind contributions for community benefit (from Worksheet 8) . . . .	183,738		183,738	0.010 %
j	Total. Other Benefits . .	595,056,340	85,379,086	509,677,254	39.860 %
k	Total. Add lines 7d and 7j .	865,271,355	135,186,472	730,084,883	57.100 %

For Paperwork Reduction Act Notice, see the Instructions for Form 990. Cat. No. 50192T Schedule H (Form 990) 2021

Schedule H (Form 990) 2021

Page

Part II

Community Building Activities Complete this table if the organization conducted any community building activities during the tax year, and describe in Part VI how its community building activities promoted the health of the communities it serves.

		(c) Total community building expense	(e) Net community building expense	(f) Percent of total expense
1	Physical improvements and housing
2	Economic development	95,610	95,610	0.010 %
3	Community support
4	Environmental improvements
5	Leadership development and training for community members
6	Coalition building
7	Community health improvement advocacy	25,487	25,487	0 %
8	Workforce development
9	Other
10	Total	121,097	121,097	0.010 %

Part III

Bad Debt, Medicare, & Collection Practices

Section A. Bad Debt Expense

Yes

Did the organization report bad debt expense in accordance with Healthcare Financial Management Association Statement No. 15? ..........................

Yes

Enter the amount of the organization's bad debt expense. Explain in Part VI the methodology used by the organization to estimate this amount. ......

Enter the estimated amount of the organization's bad debt expense attributable to patients eligible under the organization's financial assistance policy. Explain in Part VI the methodology used by the organization to estimate this amount and the rationale, if any, for including this portion of bad debt as community benefit. ......

Provide in Part VI the text of the footnote to the organization’s financial statements that describes bad debt expense or the page number on which this footnote is contained in the attached financial statements.

Section B. Medicare

Enter total revenue received from Medicare (including DSH and IME).....

Enter Medicare allowable costs of care relating to payments on line 5.....

1,700,042

Subtract line 6 from line 5. This is the surplus (or shortfall)........

-1,700,042

Describe in Part VI the extent to which any shortfall reported in line 7 should be treated as community benefit.Also describe in Part VI the costing methodology or source used to determine the amount reported on line 6.Check the box that describes the method used:

Cost accounting system Cost to charge ratio Other

Section C. Collection Practices

Did the organization have a written debt collection policy during the tax year? ..........

Yes

If "Yes," did the organization’s collection policy that applied to the largest number of its patients during the tax year
contain provisions on the collection practices to be followed for patients who are known to qualify for financial assistance? Describe in Part VI .........................

Yes

Part IV

Management Companies and Joint Ventures(owned 10% or more by officers, directors, trustees, key employees, and physicians—see instructions)

(a) Name of entity	(b) Description of primary activity of entity	(c) Organization's profit % or stock ownership %	(d) Officers, directors, trustees, or key employees' profit % or stock ownership %	(e) Physicians' profit % or stock ownership %
1
2
3
4
5
6
7
8
9
10
11
12
13

Schedule H (Form 990) 2021

Page

Part VFacility Information

Section A. Hospital Facilities (list in order of size from largest to smallest—see instructions)How many hospital facilities did the organization operate during the tax year?1Name, address, primary website address, and state license number (and if a group return, the name and EIN of the subordinate hospital organization that operates the hospital facility)
1	ST JUDE CHILDREN'S RESEARCH HOSPITAL 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 WWW.STJUDE.ORG TN STATE LICENSE NUMBER 0000000113	X	X	X	X

Schedule H (Form 990) 2021

Page 4

Part VFacility Information (continued)

Section B. Facility Policies and Practices

(Complete a separate Section B for each of the hospital facilities or facility reporting groups listed in Part V, Section A)

	ST JUDE CHILDREN'S RESEARCH HOSPITAL
Name of hospital facility or letter of facility reporting group

Line number of hospital facility, or line numbers of hospital facilities in a facility
reporting group (from Part V, Section A):

Yes

Community Health Needs Assessment

Was the hospital facility first licensed, registered, or similarly recognized by a state as a hospital facility in the current tax year or the immediately preceding tax year?........................

Was the hospital facility acquired or placed into service as a tax-exempt hospital in the current tax year or the immediately preceding tax year? If “Yes,” provide details of the acquisition in Section C...............

During the tax year or either of the two immediately preceding tax years, did the hospital facility conduct a community health needs assessment (CHNA)? If "No," skip to line 12......................

Yes

If "Yes," indicate what the CHNA report describes (check all that apply):

A definition of the community served by the hospital facility

Demographics of the community

Existing health care facilities and resources within the community that are available to respond to the health needs of the community

How data was obtained

The significant health needs of the community

Primary and chronic disease needs and other health issues of uninsured persons, low-income persons, and minority groups

The process for identifying and prioritizing community health needs and services to meet the community health needs

The process for consulting with persons representing the community’s interests

The impact of any actions taken to address the significant health needs identified in the hospital facility's prior CHNA(s)

Other (describe in Section C)

Indicate the tax year the hospital facility last conducted a CHNA: 20 21

In conducting its most recent CHNA, did the hospital facility take into account input from persons who represent the broad interests of the community served by the hospital facility, including those with special knowledge of or expertise in public health? If "Yes," describe in Section C how the hospital facility took into account input from persons who represent the community, and identify the persons the hospital facility consulted .................

Yes

6 a

Was the hospital facility’s CHNA conducted with one or more other hospital facilities? If "Yes," list the other hospital facilities in Section C..................................

Was the hospital facility’s CHNA conducted with one or more organizations other than hospital facilities?” If “Yes,” list the other organizations in Section C. ............................

Did the hospital facility make its CHNA report widely available to the public?..............

Yes

If "Yes," indicate how the CHNA report was made widely available (check all that apply):

Hospital facility’s website (list url): SEE PART V, SECTION C

Other website (list url):

Made a paper copy available for public inspection without charge at the hospital facility

Other (describe in Section C)

Did the hospital facility adopt an implementation strategy to meet the significant community health needs
identified through its most recently conducted CHNA? If "No," skip to line 11. ..............

Yes

Indicate the tax year the hospital facility last adopted an implementation strategy: 20 21

Is the hospital facility's most recently adopted implementation strategy posted on a website?.........

Yes

If "Yes" (list url): SEE PART V, SECTION C

If "No," is the hospital facility’s most recently adopted implementation strategy attached to this return? ......

10b

Describe in Section C how the hospital facility is addressing the significant needs identified in its most recently conducted CHNA and any such needs that are not being addressed together with the reasons why such needs are not being addressed.

12a

Did the organization incur an excise tax under section 4959 for the hospital facility's failure to conduct a CHNA as required by section 501(r)(3)?...............................

12a

If "Yes" on line 12a, did the organization file Form 4720 to report the section 4959 excise tax?........

12b

If "Yes" on line 12b, what is the total amount of section 4959 excise tax the organization reported on Form 4720 for all of its hospital facilities? $

Schedule H (Form 990) 2021

Page 5

Part VFacility Information (continued)

Financial Assistance Policy (FAP)

	ST JUDE CHILDREN'S RESEARCH HOSPITAL
Name of hospital facility or letter of facility reporting group

Yes

Did the hospital facility have in place during the tax year a written financial assistance policy that:

Explained eligibility criteria for financial assistance, and whether such assistance included free or discounted care?

Yes

If “Yes,” indicate the eligibility criteria explained in the FAP:

Federal poverty guidelines (FPG), with FPG family income limit for eligibility for free care of %
and FPG family income limit for eligibility for discounted care of %

Income level other than FPG (describe in Section C)

Asset level

Medical indigency

Insurance status

Underinsurance discount

Residency

Other (describe in Section C)

Explained the basis for calculating amounts charged to patients?.................

Yes

Explained the method for applying for financial assistance?...................

Yes

If “Yes,” indicate how the hospital facility’s FAP or FAP application form (including accompanying instructions) explained the method for applying for financial assistance (check all that apply):

Described the information the hospital facility may require an individual to provide as part of his or her application

Described the supporting documentation the hospital facility may require an individual to submit as part of his or
her application

Provided the contact information of hospital facility staff who can provide an individual with information about the
FAP and FAP application process

Provided the contact information of nonprofit organizations or government agencies that may be sources of
assistance with FAP applications

Other (describe in Section C)

Was widely publicized within the community served by the hospital facility?........

Yes

If "Yes," indicate how the hospital facility publicized the policy (check all that apply):

The FAP was widely available on a website (list url):

SEE PART V, SECTION C

The FAP application form was widely available on a website (list url):

SEE PART V, SECTION C

A plain language summary of the FAP was widely available on a website (list url):
SEE PART V, SECTION C

The FAP was available upon request and without charge (in public locations in the hospital facility and by mail)

The FAP application form was available upon request and without charge (in public locations in the hospital facility
and by mail)

A plain language summary of the FAP was available upon request and without charge (in public locations in the
hospital facility and by mail)

Individuals were notified about the FAP by being offered a paper copy of the plain language summary of the FAP, by
receiving a conspicuous written notice about the FAP on their billing statements, and via conspicuous public displays or
other measures reasonably calculated to attract patients' attention

Notified members of the community who are most likely to require financial assistance about availability of the FAP

The FAP, FAP application form, and plain language summary of the FAP were translated into the primary language(s)
spoken by LEP populations

Other (describe in Section C)

Schedule H (Form 990) 2021

Page 6

Part VFacility Information (continued)

Billing and Collections

	ST JUDE CHILDREN'S RESEARCH HOSPITAL
Name of hospital facility or letter of facility reporting group

Yes

Did the hospital facility have in place during the tax year a separate billing and collections policy, or a written financial assistance policy (FAP) that explained all of the actions the hospital facility or other authorized party may take upon nonpayment?..................................

Yes

Check all of the following actions against an individual that were permitted under the hospital facility's policies during the tax year before making reasonable efforts to determine the individual’s eligibility under the facility’s FAP:

Reporting to credit agency(ies)

Selling an individual’s debt to another party

Deferring, denying, or requiring a payment before providing medically necessary care due to nonpayment of a previous
bill for care covered under the hospital facility's FAP

Actions that require a legal or judicial process

Other similar actions (describe in Section C)

None of these actions or other similar actions were permitted

Did the hospital facility or other authorized party perform any of the following actions during the tax year before making reasonable efforts to determine the individual’s eligibility under the facility’s FAP?............

If "Yes," check all actions in which the hospital facility or a third party engaged:

Reporting to credit agency(ies)

Selling an individual’s debt to another party

Deferring , denying, or requiring a payment before providing medically necessary care due to nonpayment of a previous
bill for care covered under the hospital facility's FAP

Actions that require a legal or judicial process

Other similar actions (describe in Section C)

Indicate which efforts the hospital facility or other authorized party made before initiating any of the actions listed (whether or not checked) in line 19. (check all that apply):

Provided a written notice about upcoming ECAs (Extraordinary Collection Action) and a plain language summary of the
FAP at least 30 days before initiating those ECAs (if not, describe in Section C)

Made a reasonable effort to orally notify individuals about the FAP and FAP application process (if not, describe in
Section C)

Processed incomplete and complete FAP applications (if not, describe in Section C)

Made presumptive eligibility determinations (if not, describe in Section C)

Other (describe in Section C)

None of these efforts were made

Policy Relating to Emergency Medical Care

Did the hospital facility have in place during the tax year a written policy relating to emergency medical care that required the hospital facility to provide, without discrimination, care for emergency medical conditions to individuals regardless of their eligibility under the hospital facility’s financial assistance policy?..................

Yes

If "No," indicate why:

The hospital facility did not provide care for any emergency medical conditions

The hospital facility’s policy was not in writing

The hospital facility limited who was eligible to receive care for emergency medical conditions (describe in Section C)

Other (describe in Section C)

Schedule H (Form 990) 2021

Page 7

Part VFacility Information (continued)

Charges to Individuals Eligible for Assistance Under the FAP (FAP-Eligible Individuals)

	ST JUDE CHILDREN'S RESEARCH HOSPITAL
Name of hospital facility or letter of facility reporting group

Yes

Indicate how the hospital facility determined, during the tax year, the maximum amounts that can be charged to FAP-eligible individuals for emergency or other medically necessary care.

The hospital facility used a look-back method based on claims allowed by Medicare fee-for-service during a prior 12-month period

The hospital facility used a look-back method based on claims allowed by Medicare fee-for-service and all private health insurers that pay claims to the hospital facility during a prior 12-month period

The hospital facility used a look-back method based on claims allowed by Medicaid, either alone or in combination with
Medicare fee-for-service and all private health insurers that pay claims to the hospital facility during a prior 12-month
period

The hospital facility used a prospective Medicare or Medicaid method

During the tax year, did the hospital facility charge any FAP-eligible individual to whom the hospital facility provided emergency or other medically necessary services more than the amounts generally billed to individuals who had insurance covering such care? ...............................

If "Yes," explain in Section C.

During the tax year, did the hospital facility charge any FAP-eligible individual an amount equal to the gross charge for any service provided to that individual? ...........................

If "Yes," explain in Section C.

Schedule H (Form 990) 2021

Page 8

Part V

Facility Information (continued)

Section C. Supplemental Information for Part V, Section B. Provide descriptions required for Part V, Section B, lines 2, 3j, 5, 6a, 6b, 7d, 11, 13b, 13h, 15e, 16j, 18e, 19e, 20a, 20b, 20c, 20d, 20e, 21c, 21d, 23, and 24. If applicable, provide separate descriptions for each hospital facility in a facility reporting group, designated by facility reporting group letter and hospital facility line number from Part V, Section A (“A, 1,” “A, 4,” “B, 2,” “B, 3,” etc.) and name of hospital facility.
Form and Line Reference	Explanation
ST. JUDE CHILDREN'S RESEARCH HOSPITAL	PART V, SECTION B, LINE 5: THE FISCAL YEAR 2022 CHNA BUILDS UPON THE FISCAL YEAR 2019 CHNA AND REFLECTS THE ACTIVITIES IDENTIFIED IN THE FISCAL YEAR 2019 COMMUNITY BENEFIT IMPLEMENTATION PLAN FOR ST. JUDE. THE FISCAL YEAR 2022 CHNA WAS LED BY AN INTERNAL TEAM OF ST. JUDE STAFF MEMBERS. THE LEADERSHIP OF THIS TEAM ENGAGED HEALTH RESOURCES IN ACTION (HRIA), A NON-PROFIT PUBLIC HEALTH CONSULTANCY ORGANIZATION, TO CONDUCT THE CHNA. TO DEVELOP A SOCIAL, ECONOMIC, AND HEALTH PORTRAIT OF THE COMMUNITY SERVED BY ST. JUDE, HRIA REVIEWED EXISTING DATA DRAWN FROM ST. JUDE, LOCAL, STATE, AND NATIONAL SOURCES. IN ADDITION TO ANALYZING QUANTITATIVE DATA, HRIA CONDUCTED QUALITATIVE RESEARCH WITH INTERNAL AND EXTERNAL ST. JUDE STAKEHOLDERS AS WELL AS FAMILY MEMBERS AND FORMER PATIENTS IN ORDER TO SUPPLEMENT QUANTITATIVE FINDINGS WITH PERCEPTIONS OF COMMUNITY STRENGTHS AND ASSETS, PRIORITY HEALTH CONCERNS, AND SUGGESTIONS FOR FUTURE PROGRAMMING AND SERVICES.FOCUS GROUPS WERE CONDUCTED WITH CURRENT AND FORMER ST. JUDE PATIENTS, PATIENT CAREGIVERS, AND ST. JUDE CLINICAL, RESEARCH, AND ADMINISTRATIVE STAFF. DIFFERENT TOPIC AREAS WERE EXPLORED BASED ON THE UNIQUE EXPERIENCES OF EACH OF THE GROUPS.HRIA CONDUCTED 27 INTERVIEWS WITH 34 INDIVIDUALS; 13 INTERVIEWS WERE CONDUCTED WITH 19 STAFF OF ST. JUDE HOSPITAL, AND 12 INTERVIEWS WERE CONDUCTED WITH INDIVIDUALS FROM OUTSIDE THE ORGANIZATION. INTERVIEW PARTICIPANTS REPRESENTED A RANGE OF SECTORS, INCLUDING LEADERS IN HEALTH CARE AND HEALTH RESEARCH, GOVERNMENT, AND SOCIAL SERVICE ORGANIZATIONS FOCUSING ON VULNERABLE POPULATIONS. ADDITIONALLY, TWO INTERVIEWS WERE CONDUCTED WITH TWO FORMER ST. JUDE PATIENTS. EXTERNAL KEY INFORMANT INTERVIEWS WERE CONDUCTED WITH PEDIATRICS EAST, THE UNIVERSITY OF MEMPHIS, SCHOOL OF PUBLIC HEALTH, CHRIST COMMUNITY HEALTH SERVICES, LE BONHEUR CHILDREN'S HOSPITAL, TENNESSEE DEPARTMENT OF HEALTH, SHELBY COUNTY HEALTH DEPARTMENT, CHURCH HEALTH, AND SHELBY COUNTY GOVERNMENT.
ST. JUDE CHILDREN'S RESEARCH HOSPITAL	PART V, SECTION B, LINE 13H: NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.
ST. JUDE CHILDREN'S RESEARCH HOSPITAL	PART V, SECTION B, LINE 15E: NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.
ST. JUDE CHILDREN'S RESEARCH HOSPITAL	PART V, SECTION B, LINE 20E: ST. JUDE DOES NOT TAKE ANY OF THE COLLECTION ACTIONS DESCRIBED IN PART V, SECTION B, LINE 19 BECAUSE ST. JUDE COVERS ALL TREATMENTS, COPAYS, DEDUCTIBLES, COINSURANCE AND ANY OTHER COST SHARING OBLIGATIONS THAT ARE NOT COVERED BY INSURANCE. ST. JUDE TAKES NO ACTION TO COLLECT FROM PATIENTS OR THEIR FAMILIES AND DOES NOT REPORT TO CREDIT AGENCIES.
ST. JUDE CHILDREN'S RESEARCH HOSPITAL:	PART V, SECTION B, LINE 11: ST. JUDE CHILDREN'S RESEARCH HOSPITAL CONDUCTED AND ADOPTED ITS FOURTH COMMUNITY HEALTH NEEDS ASSESSMENT (CHNA) DURING TAX YEAR 2021 AND INTENDS TO ADDRESS THE FOLLOWING SIGNIFICANT HEALTH NEEDS, LISTED IN ORDER OF PRIORITY: AIM 1: IMPROVING ACCESS TO MENTAL HEALTH SUPPORTS AND SERVICES IN THE COMMUNITY, BEYOND THOSE RELATED TO PATIENT DIAGNOSIS AND TREATMENT. AIM 2: IMPROVING ACCESS TO PROVIDERS, RESOURCES, AND COORDINATED CARE DURING THE TRANSITION OF CARE FROM ST. JUDE AND ITS AFFILIATES TO COMMUNITY AND/OR ADULT CARE.AIM 3: IMPROVING ACCESS AND EQUITY TO CLINICAL TRIALS AT ST. JUDE AND ITS AFFILIATES.AIM 4: CONDUCTING CANCER PREVENTION WORK THROUGH EDUCATION AND HPV VACCINATION.AIM 5: INCREASING AWARENESS AND EDUCATION OF SICKLE CELL DISEASE AND INFECTIOUS DISEASES (HIV/AIDS) IN THE COMMUNITY.AIM 6: STRENGTHEN COMMUNITY PARTNERSHIPS IN THE GREATER MEMPHIS AREA TO ADDRESS SOCIAL DETERMINANTS OF HEALTH FOR LOCAL PATIENTS.CUTTING ACROSS ALL OF THESE AIMS IS THE COMMITMENT TO ADDRESS EQUITY AND TO IDENTIFY OPPORTUNITIES FOR COLLABORATION. GIVEN ITS FOCUSED MISSION AND MODEL OF PROVIDING SPECIALIZED SERVICES TO CHILDREN IN CRISIS, ST. JUDE DOES NOT HAVE THE CAPACITY OR RESOURCES TO MEET ALL NEEDS OF ALL CHILDREN AND THEIR FAMILIES. HOWEVER, STRATEGIC PARTNERSHIPS WITH OTHER HEALTHCARE PROVIDERS AND WITH SCHOOLS AND COMMUNITY-BASED ORGANIZATIONS ALLOW ST. JUDE TO CREATE A NETWORK OF RESOURCES THAT CAN BE LEVERAGED TO MEET THE HEALTH AND SOCIAL NEEDS OF A WIDER COMMUNITY OF PATIENTS AND THEIR FAMILIES.THIS CHNA WAS CONDUCTED AND ADOPTED AT THE END OF TAX YEAR 2021; THEREFORE, THESE HEALTH NEEDS WILL BE ADDRESSED OVER THE THREE TAX YEARS, 2022 - 2024.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. DID TAKE THE FOLLOWING ACTIONS DURING TAX YEAR 2021 WITH RESPECT TO THE CHNA CONDUCTED IN 2018:AIM #1 IMPROVING ACCESS TO CAREHEALTH NEED IDENTIFIED: IMPROVING ACCESS TO CARE - PALLIATIVE CARESTRATEGY 1. RECRUIT AND TRAIN FIVE PHYSICIAN FELLOWS IN THE PALLIATIVE CARE TRAINING PROGRAM, 2 PEDIATRIC FELLOWS, 3 ADULT/MED-PEDS FELLOWS.STRATEGY 2. PROVIDE TRAINING IN PALLIATIVE CARE FOR HEALTHCARE PERSONNEL THROUGH TARGETED CONFERENCES AND OTHER EDUCATIONAL OPPORTUNITIES INCLUDING END-OF-LIFE NURSING EDUCATION CONSORTIUM (ELNEC) CONFERENCE, A REGIONAL ELNEC OFFERING FOR OUR REGIONAL HOSPICE AND PALLIATIVE CARE NURSES, AN INSTITUTION-DEVELOPED QUALITY OF LIFE SEMINAR (QOLA), AND A 1-DAY REGIONAL PEDIATRIC ONCOLOGY PALLIATIVE CARE CONFERENCE.STRATEGY 3. EDUCATE COMMUNITY PROVIDERS ABOUT PALLIATIVE CARE MEDICINE (PCM) THROUGH COMMUNITY-BASED BRIDGING PROGRAMS FOR HOME HEALTH AND HOSPICE CARE THROUGH THE QUALITY OF LIFE FOR ALL KIDS PROGRAM VIA A THREE-HOUR DIDACTIC CURRICULUM.STRATEGY 4. ENHANCE TRAINING OPPORTUNITIES WITH ST. JUDE AFFILIATES.ACTIONS TAKEN: - HOSTED A VIRTUAL PEDIATRIC PALLIATIVE ONCOLOGY SYMPOSIUM (PPOS) WITH FREE REGISTRATION; APPROXIMATELY 1800 PARTICIPANTS IN THE EVENT. - EXPANDED AFFILIATE-BASED BEREAVEMENT SUPPORT THROUGH QOLA GRIEF AND BEREAVEMENT PROGRAM.HEALTH NEED IDENTIFIED: SERVICES AND RESOURCES FOR CAREGIVERSSTRATEGY 1. DEVELOP AN INSTITUTIONAL PARENT MENTAL HEALTH TASK FORCE WITH REPRESENTATION FROM RELEVANT SERVICES.STRATEGY 2. INTRODUCE NINA ANTONIOTTI, DIRECTOR OF INTEROPERABILITY AND PATIENT ENGAGEMENT, TO THE TELEHEALTH SUBCOMMITTEE OF THE PARENT MENTAL HEALTH TASK FORCE.STRATEGY 3. DEVELOP CRITERIA FOR TELE-MENTAL HEALTH AND OUTCOMES OF THE PROGRAM.STRATEGY 4. WRITE AN RFP, INCLUDING FEEDBACK FROM DEPARTMENT OF PSYCHOLOGY AND SOCIAL WORK.STRATEGY 5. SEND OUT REQUEST FOR PROPOSALS, TO BE RETURNED BY MAY 28, 2019.STRATEGY 6. SELECTION OF COMPANIES FOR ONSITE DEMONSTRATIONS WITH SUBCOMMITTEE.STRATEGY 7. SELECTION OF FINAL TELE-MENTAL HEALTH COMPANY.STRATEGY 8. REVIEW OF ARCADIAN TELEPSYCHIATRY SERVICE AGREEMENT BY ST. JUDE LEGAL SERVICES.STRATEGY 9. BEGIN WORKFLOW DOCUMENTATION FOR REFERRALS, INCLUDING PROCESS FOR CAREGIVERS HAVING PRESCRIPTIONS FILLED AT THE ST. JUDE PHARMACY.ACTIONS TAKEN: - CONDUCTED A MARKET SURVEY AND SELECTED A NEW TELEMENTAL HEALTH PROVIDER, WELLNITE, THAT MEETS MANY OF THE OBJECTIVES AND OUTCOMES LISTED ABOVE. - PROVIDED SAME DAY THERAPIST SERVICES FOR CAREGIVERS WHO NEED THERAPY AND BEREAVEMENT OR HOSPICE SUPPORT. - INCREASED THE NUMBER OF REFERRALS SIGNIFICANTLY OVER THE LAST TWO YEARS' VOLUMES. - CONTRACTED FOR A LOCAL PSYCHIATRIST WHO CAN SEE CAREGIVERS WITHIN 48 HOURS OF REFERRAL WHO NEED CONTROLLED SUBSTANCE MEDICATION MANAGEMENT. AIM #2 IMPROVING COORDINATION OF CAREHEALTH NEED IDENTIFIED: TRANSITION OF PATIENTS FROM PEDIATRIC TO ADULT HEALTHCARE - SICKLE CELLSTRATEGY 1. CONTINUE TO WORK WITH ADULT SICKLE CELL CENTERS IN THE COMMUNITY TO ENHANCE A SEAMLESS TRANSITION FROM PEDIATRIC CARE.STRATEGY 2. ENHANCE ADOLESCENT AND YOUNG ADULTS (AYA) TRANSITION CLINICS WITH CO-LOCATION OF PEDIATRIC AND ADULT HEMATOLOGY PROVIDERS.STRATEGY 3. AUGMENT FORMAL PROGRAMMING AND PLANNING PROCESSES FOR ADOLESCENTS WITH HEMATOLOGIC AND ONCOLOGIC DISEASES, THROUGH DEVELOPMENT OF DISEASE EDUCATIONAL CURRICULUM, TRAINING MODULES AND WEBSITE TO FOSTER INCREASED ADOLESCENT AUTONOMY AND MEDICAL LITERACY.STRATEGY 4. RECRUIT FOR NEW SICKLE CELL FELLOWSHIP.ACTIONS TAKEN: - TRANSITION NAVIGATOR WAS HIRED BY METHODIST AND WORKS PART-TIME AT ST. JUDE ADOLESCENT SICKLE CELL DISEASE (SCD) CLINIC TO SUPPORT EMERGING ADULTS IN ENGAGING IN THEIR FIRST AND SUBSEQUENT VISITS. - 47 PATIENTS WITH SCD WERE TRANSFERRED CARE FROM ST. JUDE TO ADULT CLINICS, COMPRISING A RATE OF ADULT CARE PLACEMENT OF 94% FOR THE PAST YEAR. - 8 PATIENTS ATTENDED THE TRANSITION TOUR THIS PAST YEAR. - 139 PATIENTS RECEIVED TRANSITION EDUCATION THIS PAST YEAR. - TWO ADULT HEMATOLOGISTS NOW ATTEND THE ADOLESCENT CLINIC AT ST. JUDE.HEALTH NEED IDENTIFIED: TRANSITION OF PATIENTS FROM PEDIATRIC TO ADULT HEALTHCARE - CANCER SURVIVORSSTRATEGY 1. PROVIDE WORKSHOPS AND SPEAKERS THAT OFFER INFORMATION ABOUT AVAILABLE RESOURCES.STRATEGY 2. GIVE SURVIVORS AND THEIR FAMILIES THE OPPORTUNITY TO LEARN FROM OTHER SURVIVORS.STRATEGY 3. ENSURE THAT SURVIVORS UNDERSTAND HOW TO APPROACH HEALTHCARE POST-TREATMENT.STRATEGY 4. OFFER AN ONLINE RESOURCE FOR CONTINUOUS FLOW OF SURVIVORSHIP INFORMATION (TOGETHER).STRATEGY 5. ASSESS LATE EFFECTS OF CANCER THERAPY ON PEDIATRIC CANCER SURVIVORS.STRATEGY 6. USE INFORMATION FROM THESE STUDIES TO DEFINE RISK GROUPS FOR VARIOUS LATE EFFECTS AND ASSESS INTERVENTION.
ACTIONS TAKEN:	- SURVIVORSHIP CLINICAL ACTIVITIES HAVE FOCUSED ON EDUCATING SURVIVORS ABOUT POTENTIAL HEALTH RISKS AND RISK MITIGATION MEASURES AND FACILITATING THEIR ACCESS TO SURVEILLANCE AND REMEDIAL INTERVENTION. SURVIVORS AND FAMILIES ARE COUNSELED TO ENROLL IN THE PATIENT PORTAL AND OR APP TO ENSURE THEY HAVE OPTIMAL ACCESS TO CLINICAL DATA TO SHARE WITH LOCAL HEALTH CARE PROVIDERS AND THAT THE INSTITUTION HAS ACCURATE CONTACT INFORMATION. - THE SURVIVORSHIP TEAM HAS PARTICIPATED IN A VARIETY OF ONLINE/VIRTUAL FORUMS TO EDUCATE SURVIVORS/FAMILIES, GRADUATE MEDICAL TRAINEES, AND BEHAVIORAL AND MEDICAL HEALTH CARE PROVIDERS ABOUT SURVIVORSHIP CARE. EXAMPLES OF LECTURES/SEMINARS FOLLOW: -- DR. MELISSA M. HUDSON: SCIENCE OF CHILDHOOD CANCER VIRTUAL LECTURE SERIES, "THE ROLE OF SURVIVORSHIP RESEARCH IN ADVANCING CHILDHOOD CANCER CARE AND QUALITY OF SURVIVAL", SEPTEMBER 2, 2021. -- DR. MATTHEW EHRHARDT: SURVIVORSHIP CARE PLANNING. VIVA FOUNDATION FOR CHILDREN WITH CANCER ANNUAL CONFERENCE, VIRTUAL (SINGAPORE), JANUARY 2022. -- DR. STEPHANIE DIXON: DIXON SB. OPTIMAL MANAGEMENT AND TREATMENT COORDINATION OF LONG-TERM TOXICITIES IN PEDIATRIC LEUKEMIA. GLOBAL LEUKEMIA ACADEMY LATIN AMERICA 2022: EMERGING AND PRACTICAL CONCEPTS AND CONTROVERSIES IN LEUKEMIAS. MARCH 2022. -- DR. DANIEL MULROONEY: ORGAN HEALTH AFTER CHILDHOOD CANCER - CARDIAC LATE EFFECTS, ST. JUDE CHILDREN'S RESEARCH HOSPITAL-VIVA SURVIVORSHIP, JANUARY 2022.HEALTH NEED IDENTIFIED: OUTPATIENT CARE EXPERIENCE - TRANSITION OF CARE FROM SPECIALTY TO PRIMARY CARE PROVIDERSSTRATEGY 1. DEVELOP MATERIALS TO EDUCATE PATIENTS ON THE PROCESS OF FINDING A PRIMARY CARE PROVIDER IN THEIR COMMUNITY WHO ACCEPTS THEIR HEALTH INSURANCE.STRATEGY 2. WORK WITH HIMS/CLINICAL INFORMATICS TO REVIEW STATISTICS/REPORTS RE: "FAMILY PHYSICIAN" FIELD IN EMR.STRATEGY 3. DEVELOP PROCESS FOR CAPTURING OUTCOMES RELATED TO PRIMARY CARE PROVIDER IDENTIFICATION.STRATEGY 4. INCREASE THE PERCENTAGE OF ONCOLOGY TREATMENT SUMMARIES SENT TO PRIMARY CARE PROVIDERS WITHIN TWO WEEKS OF THERAPY COMPLETION. ACTIONS TAKEN: - PROVIDE EDUCATIONAL MATERIALS TO PATIENTS WHO NEED HEALTH CARE PROVIDERS IN THEIR LOCAL COMMUNITIES. - DEVELOPED A NEW HANDOUT IDENTIFYING LOCAL MENTAL HEALTH PROVIDERS. - IMPLEMENTED NEW EPIC REPORT TO TRACK STATISTICS. - CREATED "TRANSITION" TAB IN EPIC WHERE IS READILY VIEWABLE BY PATIENT'S CARE TEAM. - CREATED A WORKING GROUP WHO ARE TASKED WITH DESIGNING AN EVIDENCE-BASED CLINICAL PATHWAY TO GUIDE THE TRANSITION FROM ST. JUDE SUB-SPECIALISTS TO SUB-SPECIALISTS IN THE PATIENT'S LOCAL COMMUNITY. - ADDED AN "ESTIMATED DATE OF THERAPY COMPLETION" FIELD IN EPIC TO FACILITATE TIMELY TRANSITION PLANNING AND COMMUNICATION BETWEEN CARE TEAMS. HEALTH NEED IDENTIFIED: OUTPATIENT CARE EXPERIENCE - PHYSICIAN COORDINATION OF CARE STRATEGY 1. CONTINUE TO IMPROVE THE CLINICIAN PORTAL TO PERMIT REFERRING AND AFFILIATED PHYSICIANS' CONVENIENT ACCESS TO PATIENT INFORMATION, IN ACCORDANCE WITH APPLICABLE LAW.ACTIONS TAKEN: - AFFILIATE PROGRAM COMPLETED A QUALITY IMPROVEMENT PROJECT TO IMPROVE COMMUNICATION AND TRANSITION FLOW FOR SHARED AFFILIATE PATIENTS ON NON-PROTOCOL TREATMENT PLANS. - COMPLETED ANNUAL COMMUNICATION SURVEY WHICH HELPS TO GUIDE NEW COORDINATION OF CARE INITIATIVES. - EXPANDED THE AFFILIATE NAVIGATOR PROGRAM TO INCLUDE CARE COORDINATION. - INTRODUCED CARE EVERYWHERE AND EPIC CARE LINK PROCESSES TO FACILITATE REFERRALS, CLINICIAN ACCESS TO PATIENT INFORMATION AND TRANSITION OF CARE ACTIVITIES. AIM #3 IMPROVING CHILD HEALTH STATUSHEALTH NEED IDENTIFIED: COMMUNITY HEALTH EDUCATIONSTRATEGY 1. ST. JUDE PROFESSIONALS WILL PROVIDE INFORMATION AND RESOURCES ABOUT SICKLE CELL DISEASE, HIV, CANCER, FLU, AND OTHER PEDIATRIC LIFE-THREATENING DISEASES.STRATEGY 2. OFFER EDUCATIONAL OPPORTUNITIES AND OTHER INFORMATION ABOUT HEALTHCARE CAREERS.ACTIONS TAKEN: - TOGETHER BY ST. JUDE WEBSITE PROVIDES RELIABLE MEDICAL EXPLANATIONS AND CLINICAL CARE INFORMATION IN EASY-TO-UNDERSTAND LANGUAGE. IT IS AVAILABLE TO PATIENTS AND THEIR FAMILIES ANYWHERE IN THE WORLD WITH CONTENT IS NOW AVAILABLE IN 10 LANGUAGES: ENGLISH, ARABIC, BURMESE, CHINESE (SIMPLIFIED), FRENCH, HINDI, PORTUGUESE, RUSSIAN, SPANISH AND URDU. - VACCINES BRING US CLOSER CAMPAIGN ILLUSTRATES THE IMPORTANCE OF THE COVID-19 VACCINE AND ITS ROLE IN HELPING TO END THE PANDEMIC. THE CAMPAIGN BEGAN AS AN INTERNAL INITIATIVE FOCUSED ON EMPLOYEE VACCINATION TO KEEP PATIENTS AND THEIR FAMILIES SAFE FROM COVID-19, BUT EXPANDED TO EXTERNAL AUDIENCES THROUGH STORIES, VIDEOS AND GRAPHICS FEATURED ON THE ST. JUDE WEBSITE AND SOCIAL MEDIA PLATFORMS. - PROGRESS BLOG POSTS: ST. JUDE PUBLISHED 40BLOG POSTS THIS YEAR WITH EDUCATIONAL INFORMATION ONBASIC RESEARCH, COVID-19, HPV, SAFER UKRAINE, AND GENERAL CHILDHOOD CANCER AND HEALTH RESOURCES. - COMMUNITY EDUCATION AND ENGAGEMENT: IN FY22, ST. JUDE OPENED THE DOOR TO HEALTH CARE CAREER POSSIBILITIES FOR MORE THAN 1,400 LOCAL EIGHTH GRADERS DURING THE JUNIOR ACHIEVEMENT OF MEMPHIS AND THE MID-SOUTH'S INSPIRE EXPO. THE INTERACTIVE BOOTH BROUGHT PATIENT AND RESEARCH SETTINGS TO LIFE FOR STUDENTS WITH ACTIVITIES SUCH AS TAKING A BLOOD PRESSURE, PERFORMING CHEST COMPRESSIONS, LOOKING UNDER A MICROSCOPE AND ENGAGING WITH RESEARCHERS AND CLINICAL STAFF.HEALTH NEED IDENTIFIED: PREVENTING VIRUS-ASSOCIATED CANCERS THROUGH INCREASED HPV VACCINATIONSTRATEGY 1. LAUNCH SEARCH COMMITTEE, DEVELOP AND EVALUATE CANDIDATES, HIRE AND ONBOARD A NEW FACULTY DIRECTOR FOR THE HPV CANCER PREVENTION INITIATIVE.STRATEGY 2. CONTINUE AND/OR STRENGTHEN PARTNERSHIPS WITH OTHERS IN THE HPV VACCINATION SPACE (E.G. NATIONAL HPV VACCINATION ROUNDTABLE, HPV CANCER FREE TENNESSEE) THROUGH ACTIVE PARTICIPATION IN COMMITTEES AND MEETINGS.
ACTIONS TAKEN:	- LAUNCHED AND IMPLEMENTED A PUBLIC AWARENESS CAMPAIGN PROMOTING ON-TIME HPV VACCINATION WITH MORE THAN 110 ORGANIZATIONAL AND INDIVIDUAL CAMPAIGN PARTNERS (PATH TO A BRIGHT FUTURE). - ESTABLISHED AND SUPPORTED THE MEMPHIS AND SHELBY COUNTY HPV CANCER PREVENTION ROUNDTABLE. - DEVELOPED STATE HPV DATA PROFILES FOR TENNESSEE, ARKANSAS, MISSOURI, MISSISSIPPI, ALABAMA, AND LOUISIANA THAT INCLUDE THE MOST CURRENT HPV DATA AND TRENDS TO INFORM ACTIONABLE OPPORTUNITIES TO INCREASE HPV VACCINATION COVERAGE. - HOSTED FIVE VIRTUAL SEMINARS IN SUPPORT OF INTERNATIONAL HPV AWARENESS DAY. THE SEMINARS HAD A TOTAL OF 785 ATTENDEES. - ADDITIONALLY, THE PROGRAM TEAM MEMBERS PARTICIPATED IN MULTIPLE MEETINGS WITH PARTNERS, INCLUDING NATIONAL HPV VACCINATION ROUNDTABLE, CDC, AMERICAN CANCER SOCIETY, HPV CANCER FREE TENNESSEE COALITION, PREVENT CANCER FOUNDATION, MERCK, GLOBAL INITIATIVE AGAINST HPV AND CERVICAL CANCER. PARTNERSHIP OUTCOMES INCLUDED THE CONVENING OF A LOCAL HPV CANCER PREVENTION ROUNDTABLE FOR MEMPHIS AND SHELBY COUNTY, AS WELL AS ENGAGEMENT WITH PARTNERS IN ALABAMA, ARKANSAS, LOUISIANA, MISSISSIPPI, MISSOURI, AND TENNESSEE BY PARTICIPATING IN STATE-LEVEL COALITIONS AND WITH ORGANIZATIONS ADDRESSING HPV CANCER PREVENTION IN THESE STATES. HEALTH NEED IDENTIFIED: HIV COLLABORATION WITH COMMUNITY COALITIONSTRATEGY 1. FORGE ACTION-ORIENTED PARTNERSHIPS BETWEEN HEALTH RESEARCHERS AND COMMUNITY MEMBERS.STRATEGY 2. LINK YOUTH TO CONFIDENTIAL HIV TESTING, COUNSELING SERVICES AND SPECIALIZED YOUTH CARE.STRATEGY 3. STRENGTHEN SERVICES THAT SUPPORT YOUNG PEOPLE WITH HIV AND RELATED MEDICAL AND SOCIAL PROBLEMS. STRATEGY 4. FOCUS PREVENTION STRATEGIES WHERE SOCIAL DETERMINANTS OF HEALTH EXISTS, AND HELP IS MOST NEEDED.ACTIONS TAKEN: - THE OUTREACH TEAM HOSTED 11 VIRTUAL CONNECT TO PROTECT (C2P) MEMPHIS COMMUNITY COALITION MEETINGS, AVERAGING 33 ATTENDEES. C2P MEMPHIS IS A COALITION OF 25 PLUS COMMUNITY-BASED STAKEHOLDERS WITH A SHARED VISION OF OPTIMIZING HIV PREVENTION AND TREATMENT IN SHELBY COUNTY. THESE VIRTUAL MEETINGS PROVIDED A FORUM FOR OUTSIDE COLLABORATORS ("SPARK" PROJECT [UNIVERSITY OF CONNECTICUT] AND SHIFT PROJECT [MEHARRY MEDICAL COLLEGE]) TO SHARE ABOUT RESEARCH PROJECTS. THE VIRTUAL MEETINGS HIGHLIGHTED THE WORK OF C2P MEMBER AGENCIES INCLUDING THOSE THAT HAVE RECEIVED CDC FUNDS AS PART OF ENDING THE HIV EPIDEMIC (EHE) FUNDING. - THE OUTREACH TEAM WITH THE C2P COALITION ALSO HOSTED A MEETING WITH THE LEADERSHIP OF THE FAST-TRACK CITIES INITIATIVE. THE FAST-TRACK CITIES INITIATIVE, WITH THE CORE PARTNERS OF UNAIDS, THE CITY OF PARIS, THE INTERNATIONAL ASSOCIATION OF PROVIDERS OF AIDS CARE (IAPAC) AND UN-HABITAT, SERVES TO PROVIDE SUPPORT TO PRIORITY CITIES TO "FAST-TRACK" THEIR HIV RESPONSES, TO DELIVER ON THE COMMITMENTS OF THE PARIS DECLARATION TO END THE AIDS EPIDEMIC BY 2030, AND TO ADDRESS DISPARITIES IN ACCESS TO BASIC HEALTH AND SOCIAL SERVICES, SOCIAL JUSTICE, AND ECONOMIC OPPORTUNITIES. - THE OUTREACH TEAM MAINTAINS A STRONG LINKAGE TO CARE PROGRAM IN COLLABORATION WITH THE LOCAL SHELBY COUNTY HEALTH DEPARTMENT AND COMMUNITY PARTNERS. OF THE APPROXIMATE 62 NEWLY DIAGNOSED YOUTH REFERRALS RECEIVED, 49 (UNDER 24 YEARS OF AGE), WERE LINKED TO CARE. - THE OUTREACH TEAM PARTICIPATED IN 24 OUTREACH EVENTS REACHING A TOTAL OF 1,292 INDIVIDUALS, WITH A FOCUS ON YOUTH. ENGAGEMENT AT THESE EVENTS INCLUDES DISSEMINATION OF INFORMATION ABOUT HIV PREVENTION CLINICAL TRIALS. IN FY22 THERE WERE TWO LONG-ACTING ANTIRETROVIRAL PREVENTION TRIALS THAT THE TEAM SHARED INFORMATION ABOUT IN THE COMMUNITY. - THE OUTREACH TEAM CLOSELY COLLABORATED WITH THE TENNESSEE DEPARTMENT OF HEALTH, AND WITH CDC FUNDING, ACTED AS THE ENDING THE HIV EPIDEMIC COORDINATING CENTER FOR SHELBY COUNTY. THE TEAM HELPED MAINTAIN THE HTTPS://ENDHIV901.ORG/ WEBPAGE THAT SERVES AS THE DASHBOARD FOR ALL EHE-RELATED RESOURCES IN THE COUNTY AND HELPED WITH THE SELECTION, SETUP, AND HOSTING OF THE ENDHIV901 COMMUNITY ADVISORY BOARD.HEALTH NEED IDENTIFIED: CHILD KNOWLEDGE OF CANCER PREVENTION, NUTRITION, OBESITY, AND PHYSICAL ACTIVITY STRATEGY 1. PARTNER WITH LOCAL EDUCATION AGENCIES TO DISSEMINATE CANCER AND HEALTHY LIVING EDUCATIONAL PROGRAMS.ACTIONS TAKEN: - IMPLEMENTED THE KINDERGARTEN COLLABORATIVE, A PARTNERSHIP WITH MEMPHIS SHELBY COUNTY SCHOOLS TO CO-CREATE LEARNING MODULES THAT INTEGRATE SCIENCE EDUCATION WITH LITERACY, NUMERACY, AND SOCIAL AND EMOTIONAL SKILL DEVELOPMENT. YOUNG LEARNERS EXPLORE HOW INFECTIOUS DISEASES ARE SPREAD FROM PERSON TO PERSON AND DEVELOP AN INTERVENTION THAT CAN PREVENT THE SPREAD OF DISEASE IN THEIR CLASSROOM. THE PROGRAM WAS FACILITATED AT 5 ELEMENTARY SCHOOLS WITH 12 KINDERGARTEN TEACHERS TO OVER 240 KINDERGARTEN STUDENTS. - THE AFTERSCHOOL STEM CLUBS TEACH 5TH GRADE STUDENTS ABOUT THE SIGNS AND SYMPTOMS OF OSTEOSARCOMA, POSITIONING THEM AS PHYSICIAN SCIENTISTS AND ENGINEERS TO DIAGNOSE AND TREAT THE DISEASE. THE CLUB WAS DELIVERED AT 21 ELEMENTARY SCHOOLS AND REACHED 250 5TH GRADE STUDENTS IN MEMPHIS SHELBY COUNTY SCHOOLS. - MIDDLE SCHOOL COMMUNITY HEALTH CLUBS FACILITATE MIDDLE SCHOOL STUDENTS' (GRADES 6-8) EXPLORATION OF CANCER METRICS AND SOCIAL DETERMINANTS OF HEALTH. YOUTH PARTICIPATING IN THE CLUB DEVELOP AN INFOGRAPHIC TO INCREASE AWARENESS OF UPSTREAM FACTORS THAT CREATE ENVIRONMENTS WHERE CANCER DISPARITIES CAN EXIST. THE CLUB WAS OFFERED AT 2 MIDDLE SCHOOLS AND REACHED 30 MIDDLE SCHOOL STUDENTS. - THE CANCER CONTROL AND DISPARITIES FELLOWSHIP IS A RESEARCH IMMERSION PROGRAM THAT IS COUPLED WITH A TEACHER-LED CLASSROOM LEARNING MODULE DELIVERED DURING THE ACADEMIC YEAR. AS PART OF THEIR CLASSROOM LEARNING, YOUTH EXPLORE CANCER METRICS USING DATA ON THE NCI STATE PROFILES WEBSITE TO IDENTIFY CANCER DISPARITIES IN THEIR COMMUNITY. THEN, USING THE SOCIAL DETERMINANTS OF HEALTH FRAMEWORK, THEY PROPOSE A CANCER CONTROL PROGRAM THAT ADDRESSES UPSTREAM FACTORS THAT CREATE ENVIRONMENTS WHERE THESE DISPARITIES CAN EXIST. STUDENTS WHO PARTICIPATE IN THE CURRICULUM ARE ELIGIBLE TO APPLY FOR A RESEARCH IMMERSION PROGRAM WHERE THEY WORK WITH A PUBLIC HEALTH EXPERT TO RESEARCH CANCER CONTROL PROGRAMS DURING THE SUMMER. THE FELLOWSHIP CURRICULUM WAS DELIVERED IN 2 SCHOOLS IN THE MEMPHIS AREA TO APPROXIMATELY 240 HIGH SCHOOL STUDENTS. - THE CANCER EDUCATION AND OUTREACH PROGRAM PARTNERED WITH THE MEMPHIS SHELBY COUNTY SCHOOLS SUMMER LEARNING ACADEMY TO OFFER CANCER AND HEALTH EDUCATION TO APPROXIMATELY 150 YOUTH.
ST. JUDE CHILDREN'S RESEARCH HOSPITAL:	PART V, SECTION B, LINE 7A: THE CHNA REPORT WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/ABOUT-ST-JUDE/FINANCIALS/COMMUNITY-HEALTH-NEEDS- ASSESSMENT.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 10A: THE HOSPTIAL FACILITY'S MOST RECENTLY ADOPTED IMPLEMENTATION STRATEGY IS AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/ABOUT-ST-JUDE/FINANCIALS/COMMUNITY-HEALTH-NEEDS- ASSESSMENT.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 14: ST. JUDE CURRENTLY DOES NOT BILL NOR PURSUE PAYMENT FOR ANY ST. JUDE PATIENT; THEREFORE, ST. JUDE DOES NOT HAVE A BASIS FOR CALCULATING AMOUNTS CHARGED TO PATIENTS.ST. JUDE CHILDREN'S RESEARCH HOSPITAL: PART V, SECTION B, LINE 16A: THE FAP WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 16B: BASED ON THE FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL- ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML), ST. JUDE DOES NOT HAVE AN APPLICATION FORM.ST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 16C: A PLAIN LANGUAGE SUMMARY WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML

Schedule H (Form 990) 2021

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Part VFacility Information (continued)

Section D. Other Health Care Facilities That Are Not Licensed, Registered, or Similarly Recognized as a Hospital Facility (list in order of size, from largest to smallest) How many non-hospital health care facilities did the organization operate during the tax year?
Name and address		Type of Facility (describe)
1
2
3
4
5
6
7
8
9
10

Schedule H (Form 990) 2021

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Part VI

Supplemental Information

Provide the following information.

1	Required descriptions. Provide the descriptions required for Part I, lines 3c, 6a, and 7; Part II and Part III, lines 2, 3, 4, 8 and 9b.
2	Needs assessment. Describe how the organization assesses the health care needs of the communities it serves, in addition to any CHNAs reported in Part V, Section B.
3	Patient education of eligibility for assistance. Describe how the organization informs and educates patients and persons who may be billed for patient care about their eligibility for assistance under federal, state, or local government programs or under the organization’s financial assistance policy.
4	Community information. Describe the community the organization serves, taking into account the geographic area and demographic constituents it serves.
5	Promotion of community health. Provide any other information important to describing how the organization’s hospital facilities or other health care facilities further its exempt purpose by promoting the health of the community (e.g., open medical staff, community board, use of surplus funds, etc.).
6	Affiliated health care system. If the organization is part of an affiliated health care system, describe the respective roles of the organization and its affiliates in promoting the health of the communities served.
7	State filing of community benefit report. If applicable, identify all states with which the organization, or a related organization, files a community benefit report.

Form and Line Reference	Explanation
PART I, LINE 3C:	NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.
PART I, LINE 7:	COST-TO-CHARGE RATIO DERIVED FROM WORKSHEET 2, RATIO OF PATIENT CARE COST TO CHARGES. COST-TO-CHARGE RATIO USED FOR LINE 7A FINANCIAL ASSISTANCE AT COST, LINE 7B MEDICAID, AND LINE 7C COSTS OF OTHER MEANS-TESTED GOVERNMENT PROGRAMS.
PART I, LINE 7G:	ST. JUDE CHILDREN'S RESEARCH HOSPITAL INCLUDED AS SUBSIDIZED HEALTH SERVICES SUPPORT FOR EIGHT AFFILIATE CLINICS TOTALING APPROXIMATELY $7.9 MILLION.
PART II, COMMUNITY BUILDING ACTIVITIES:	ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS AN ACTIVE AND ENGAGED MEMBER OF THE MEMPHIS HEALTH COMMUNITY. EMPLOYEES PARTICIPATE IN BUSINESS, EDUCATION, OUTREACH AND CIVIC PROGRAMS AND ACTIVITIES FOSTERING ECONOMIC DEVELOPMENT AND COMMUNITY HEALTH IMPROVEMENT ADVOCACY WHICH PROMOTE THE HEALTH AND WELLNESS OF THE COMMUNITIES WE SERVE.THE ST. JUDE CHILDREN'S RESEARCH HOSPITAL PRESIDENT AND CEO IS A MEMBER OF MEMPHIS TOMORROW. MEMPHIS TOMORROW IS AN ASSOCIATION OF CHIEF EXECUTIVE OFFICERS OF MEMPHIS' LARGEST ENTERPRISES. THE PURPOSE IS TO BRING TOP BUSINESS LEADERS TOGETHER WITH GOVERNMENT AND CIVIC LEADERS TO FOSTER ECONOMIC PROSPERITY FOR ALL WHO LIVE IN OUR COMMUNITY. THEIR INITIATIVES ARE FOCUSED IN THOSE AREAS WHICH DIRECTLY IMPACT ECONOMIC GROWTH AND OPPORTUNITY, INCLUDING HUMAN CAPITAL DEVELOPMENT, INDUSTRY DEVELOPMENT, AND PUBLIC SAFETY. ST. JUDE ALSO PARTICIPATES WITH MEMPHIS FAST FORWARD WHOSE STRATEGIES ARE BASED ON THE PREMISE THAT ECONOMIC GROWTH AND PROSPERITY, AND IMPROVED QUALITY OF LIFE, WILL FOLLOW ONCE MEMPHIS AND SHELBY COUNTY SUCCESSFULLY ADDRESS THE BASICS: GOOD JOBS, QUALITY EDUCATION, SAFE STREETS AND EFFICIENT GOVERNMENT. ST. JUDE IS A MEMBER OF THE ASPIRING FOR PURCHASING EXCELLENCE (APEX) ASSOCIATION OF MEMPHIS. APEX IS AN ASSOCIATION OF PURCHASING AND PROCUREMENT PROFESSIONALS FROM MEMPHIS ORGANIZATIONS WHOSE PURPOSE IS TO PROMOTE BEST PRACTICES IN SUPPLIER DIVERSITY. ADDITIONALLY, ST. JUDE IS GOLD SPONSOR FOR THE MID-SOUTH MINORITY BUSINESS COUNCIL (MMBC) ECONOMIC DEVELOPMENT FAIR. THE MMBC SERVES AS THE MID-SOUTH'S FOREMOST MINORITY BUSINESS DEVELOPMENT ORGANIZATION. THE MMBC HELPS TO DEVELOP A STRONG MINORITY AND WOMEN BUSINESS COMMUNITY TO IMPACT ECONOMICALLY THE ENTIRE MID-SOUTH REGION. THE PEDIATRIC ONCOLOGY EDUCATION (POE) PROGRAM BROUGHT IN 33 SUMMER STUDENTS FOR INTERNSHIPS IN BASIC SCIENCE OR CLINICAL RESEARCH. THE RHODES COLLEGE SUMMER PLUS PROGRAM ACCEPTS 15 STUDENTS INTO THE HOSPITAL'S RESEARCH LABORATORIES FOR A PERIOD OF ONE SUMMER, ONE ACADEMIC YEAR, AND A SECOND SUMMER. IN 2022, ST. JUDE HOSTED 16 SHELBY COUNTY HIGH SCHOOL STUDENTS FOR AN IMMERSIVE SUMMER LAB INTERNSHIP PROGRAM. THESE PROGRAMS SUPPORT INCREASING THE AWARENESS OF CAREERS IN RESEARCH SCIENCE, HEALTHCARE, OR HEALTHCARE MANAGEMENT AND CONTRIBUTE TO PREPARING STUDENTS TO ENTER THESE CAREERS. THE CLINICAL EDUCATION AND TRAINING OFFICE HOSTS APPROXIMATELY 50 STUDENTS ANNUALLY FOR PATIENT CARE SHADOWING AND ROTATION EXPERIENCES. THESE STUDENTS ARE AT DIFFERENT STAGES OF TRAINING AND ARE GENERALLY IN MEDICAL SCHOOL. THIS PROGRAM HELPS PARTICIPANTS DETERMINE THEIR CAREER IN MEDICINE ACROSS THE FIELDS OF ONCOLOGY, HEMATOLOGY AND INFECTIOUS DISEASES.THE FAMILY, GUEST AND VOLUNTEER SERVICES DEPARTMENT PROVIDES SUMMER PROGRAMS FOR HIGH SCHOOL STUDENTS AND YEAR-ROUND PROGRAMS FOR COLLEGE STUDENTS. BOTH PROGRAMS DRIVE ENTRY INTO HEALTH CAREERS. THE DEPARTMENT ALSO ENGAGES TWELVE FULL-TIME INTERNS, 4 EACH SEMESTER, WHO ARE EMBEDDED ON THE TEAM AND PREPARED FOR CAREERS IN NON-PROFIT LEADERSHIP OR HEALTHCARE MANAGEMENT. ST. JUDE OFFERS EXPERIENTIAL LEARNING INTERNSHIPS ACROSS MANY AREAS FROM SCIENCE TO LEGAL, INFORMATION SERVICES, HUMAN RESOURCES, COMMUNICATION AND ACCOUNTING. THE CHIEF GOVERNMENT AFFAIRS OFFICER SERVES ON THE BOARD OF DIRECTORS OF THE MEMPHIS RIVER PARKS PARTNERSHIP (MRPP). THE MRPP IS A NON-PROFIT ORGANIZATION THAT, UNDER A LONG-TERM CONTRACT WITH THE CITY OF MEMPHIS, MANAGES ALL THE PARKS ALONG A 5-MILE STRETCH OF THE MEMPHIS RIVERFRONT. ELEMENTS ALONG THE RIVER FOSTER HEALTHY LIFESTYLES INCLUDING RIVERFIT, A SERIES OF PHYSICAL FITNESS CHALLENGES, AND A PLAYGROUND DESIGNED SPECIFICALLY FOR CHILDREN AT BEALE ST. LANDING.THE CHIEF GOVERNMENT AFFAIRS OFFICER SERVES ON THE BOARD OF COMMISSIONERS OF THE MEMPHIS AREA TRANSIT AUTHORITY (MATA). HE HELPS TO PROMOTE THE HEALTH OF THE COMMUNITY BY ADVOCATING FOR POLICIES THAT ENABLE ENHANCED MOBILITY FOR A LARGER PERCENTAGE OF THE POPULATION OF MEMPHIS AND SHELBY COUNTY.THE CHIEF LEGAL OFFICER IS BOARD COUNSEL, AND A BOARD MEMBER OF THE MEMPHIS CHILD ADVOCACY CENTER, WHICH HELPS LOCAL CHILDREN FIND SAFETY AND HEALING (INCLUDING ACCESS TO A MENTAL HEALTH PROFESSIONAL) AFTER A REPORT OF SEXUAL OR OTHER SEVERE ABUSE AND OFFERS ABUSE PREVENTION TRAINING TO COMMUNITY VOLUNTEERS AND PARENTS. THE MANAGING COUNSEL FOR HEALTH AFFAIRS SERVES ON THE BOARD OF THE MEMPHIS BAR ASSOCIATION HEALTH LAW SECTION.
PART III, LINE 2:	BAD DEBT EXPENSE IS EQUAL TO CHARGES ON ACCOUNTS DETERMINED TO BEUNCOLLECTIBLE.THERE WERE NO UNCOLLECTIBLE ACCOUNTS IN THE CURRENT YEAR.
PART III, LINE 3:	ALL PATIENTS ARE ELIGIBLE FOR FINANCIAL ASSISTANCE UNDER THE FINANCIAL ASSISTANCE POLICY. THERE WAS NO BAD DEBT EXPENSE ATTRIBUTABLE TO PATIENTS UNDER THE FINANCIAL ASSISTANCE POLICY. ST. JUDE CHILDREN'S RESEARCH HOSPITAL DOES NOT CONSIDER BAD DEBT EXPENSE A COMMUNITY BENEFIT.
PART III, LINE 4:	NET PATIENT SERVICE REVENUES - NET OPERATING REVENUES ARE RECORDED AT THE TRANSACTION PRICE ESTIMATED BY THE HOSPITAL TO REFLECT THE TOTAL CONSIDERATION DUE FROM THIRD-PARTY PAYORS IN EXCHANGE FOR PROVIDING GOODS AND SERVICES IN PATIENT CARE. THESE SERVICES ARE CONSIDERED TO BE A SINGLE PERFORMANCE OBLIGATION AND HAVE A DURATION OF LESS THAN ONE YEAR. REVENUES ARE RECORDED AS THESE GOODS AND SERVICES ARE PROVIDED. THE TRANSACTION PRICE, WHICH INVOLVES SIGNIFICANT ESTIMATES, IS DETERMINED BASED ON THE HOSPITAL'S STANDARD CHARGES FOR THE GOODS AND SERVICES PROVIDED, WITH A REDUCTION RECORDED FOR PRICE CONCESSIONS RELATED TO THIRD PARTY CONTRACTUAL ARRANGEMENTS AS WELL AS OTHER IMPLICIT PRICE CONCESSIONS.
PART III, LINE 8:	ST. JUDE CHILDREN'S RESEARCH HOSPITAL DOES NOT CONSIDER THE MEDICARE SHORTFALL A COMMUNITY BENEFIT. THE COST TO CHARGE RATIO WAS USED TO DETERMINE MEDICARE ALLOWABLE COSTS OF CARE.
PART III, LINE 9B:	ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE WHETHER OR NOT THEY OR THEIR FAMILIES CAN PAY FOR IT. ST. JUDE DOES HAVE A BILLING SYSTEM, BUT PATIENTS DO NOT RECEIVE BILLS. IF THE PATIENT HAS INSURANCE, ST. JUDE BILLS THE INSURANCE PLAN OR OTHER ORGANIZATION THAT PAYS HEALTH COSTS. THIS IS SET FORTH IN OUR FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/ LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML).
PART VI, LINE 2:	CANCERPEDIATRIC CANCERS ARE RARE COMPARED TO ADULT CANCERS. ONLY 10,470 NEW CASES ARE EXPECTED TO OCCUR AMONG CHILDREN 14 YEARS OF AGE AND YOUNGER IN 2022; HOWEVER, CANCER IS THE LEADING CAUSE OF DISEASE-RELATED DEATH IN U.S. CHILDREN. THE PRINCIPAL FOCUS OF ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS CANCER. SEVENTY-FIVE PERCENT OF ALL RESOURCES AT ST. JUDE ARE INVESTED IN ELUCIDATING BASIC BIOLOGICAL MECHANISMS OF PEDIATRIC CANCERS AND TRANSLATING THIS KNOWLEDGE INTO IMPROVED DIAGNOSTIC TOOLS AND CURATIVE THERAPIES, WHILE MINIMIZING LONG-TERM SIDE EFFECTS. AS THE FIRST AND ONLY NATIONAL CANCER INSTITUTE-DESIGNATED COMPREHENSIVE CANCER CENTER FOCUSED EXCLUSIVELY ON CHILDREN, ST. JUDE SERVES AS A NATIONAL RESOURCE FOR RESEARCH AND TREATMENT OF PEDIATRIC CANCERS. OUR INITIATIVES ARE DESIGNED TO IMPACT PEDIATRIC CANCER TREATMENT ON A LOCAL, REGIONAL, NATIONAL AND GLOBAL SCALE. THERE ARE NO KNOWN DIFFERENCES IN PEDIATRIC CANCER INCIDENCE BY GEOGRAPHIC REGION IN THE U.S. CONSEQUENTLY, IT IS NOT POSSIBLE TO CATER OUR CLINICAL TRIALS TO TARGET PEDIATRIC CANCERS SPECIFICALLY PREVALENT IN OUR CATCHMENT AREA. WHILE NUMEROUS ADULT CANCERS HAVE BEEN SHOWN TO HAVE HIGH VARIATION IN INCIDENCE RATES ACROSS RACES AND ETHNICITIES, THE SITUATION IS LESS CLEAR IN PEDIATRIC CANCER, WHERE FEWER DISCREPANCIES HAVE BEEN IDENTIFIED. ALTHOUGH OUR CATCHMENT AREA HAS A HIGHER PROPORTION OF AFRICAN-AMERICAN PATIENTS THAN THE GENERAL U.S. POPULATION, THERE ARE VERY FEW EXAMPLES OF PEDIATRIC CANCERS IN WHICH THE INCIDENCE IS HIGHER IN RACIAL AND/OR ETHNIC MINORITIES. CONSEQUENTLY OUR RESEARCH AND CLINICAL TRIALS ADDRESS THE MOST PRESSING PROBLEMS IN PEDIATRIC CANCER. ST. JUDE OFFERS THERAPEUTIC TRIALS FOR THE TOP PEDIATRIC CANCERS INCLUDING ACUTE LYMPHOBLASTIC LEUKEMIA, MEDULLOBLASTOMA, NEUROBLASTOMA, HODGKIN LYMPHOMA, RETINOBLASTOMA, RHABDOMYOSARCOMA AND OTHERS. MANY OF THESE TRIALS ARE INSTITUTIONALLY SPONSORED; HOWEVER, ST. JUDE ALSO PARTICIPATES IN SEVERAL CLINICAL TRIALS CONSORTIA PROVIDING OUR CANCER PATIENTS ACCESS TO A VARIETY OF THERAPEUTIC STUDIES. PEDIATRIC CANCER PATIENTS MAY EXPERIENCE TREATMENT-RELATED SIDE EFFECTS MANY YEARS AFTER DIAGNOSIS. THE CHILDHOOD CANCER SURVIVOR STUDY AND ST. JUDE LIFE ARE TWO STUDIES, ACTIVE AT ST. JUDE, ASSESSING LATE EFFECTS OF CANCER THERAPY ON PEDIATRIC CANCER SURVIVORS. INFORMATION FROM THESE STUDIES WILL BE USED TO DEFINE RISK GROUPS FOR VARIOUS LATE EFFECTS AND ASSESS INTERVENTIONS. COMMUNITY OUTREACH AND ENGAGEMENT (COE) AT THE ST. JUDE COMPREHENSIVE CANCER CENTER (SJCCC) PROMOTES A COORDINATED APPROACH TO ENSURING THAT CHILDREN WHO HAVE CANCER, CHILDREN WHO HAVE SURVIVED CANCER, AND HEALTHY CHILDREN ALL BENEFIT FROM CUTTING-EDGE SCIENCE, CLINICAL CARE, AND PREVENTION EFFORTS PROVIDED BY THE SJCCC. THESE COE ACTIVITIES SPAN LOCAL, NATIONAL, AND GLOBAL GEOGRAPHIC AREAS THROUGH THE COLLECTIVE IMPACT OF THE ST. JUDE HPV CANCER PREVENTION PROGRAM, CANCER EDUCATION AND OUTREACH PROGRAM IN SCHOOLS, TOGETHER WEBSITE AND COMMUNITY, ST. JUDE AFFILIATE NETWORK, AND THE ST. JUDE GLOBAL PEDIATRIC MEDICINE PROGRAM. IN THE SUMMER OF 2022, ST. JUDE LAUNCHED THE HIGH SCHOOL AND COLLEGE RESEARCH IMMERSION PROGRAM. THIS PROGRAM OFFERED MEMPHIS-AREA HIGH SCHOOL AND COLLEGE STUDENTS AN OPPORTUNITY TO PARTICIPATE IN MENTORED RESEARCH PROJECTS IN ST. JUDE LABORATORY, PSYCHOLOGY, EPIDEMIOLOGY, CLINICAL OR DATA SCIENCE RESEARCH PROGRAMS. A PRIMARY GOAL OF THE PROGRAM WAS TO PROVIDE ACCESS AND OPPORTUNITIES TO PARTICIPATE IN MENTORED RESEARCH EXPERIENCE. THE ST. JUDE PATIENT FAMILY ADVISORY COUNCIL (PFAC) PROVIDES THE OPPORTUNITY FOR COE TO ENGAGE PATIENTS AND FAMILIES. A MEMBER OF THE COE LEADERSHIP TEAM IS ACTIVE IN THE PFAC AS A STAFF CHAMPION, ATTENDS MONTHLY MEETINGS, AND FACILITATES CONNECTIONS, AND SUPPORTS COMMUNICATION BETWEEN THE PFAC AND THE COE. THE HEALTHY CHILDREN ADVISORY COUNCIL WAS ALSO LAUNCHED IN 2021 TO MEANINGFULLY ENGAGE REPRESENTATIVES OF COMMUNITIES SERVED BY THE COMPREHENSIVE CANCER CENTER TO FUNCTION IN AN ADVISORY CAPACITY, SUCH AS BY PROVIDING ADVICE ON IDENTIFYING, PRIORITIZING, AND COMMUNICATING NEEDS ACROSS THE SJCCC AND TO COMMUNITIES. HEMATOLOGYMORE THAN 100,000 PEOPLE IN THE UNITED STATES HAVE SICKLE CELL DISEASE (SCD), AND IT IS ESTIMATED THAT MORE THAN 1 MILLION PEOPLE WORLDWIDE SUFFER FROM THE DISEASE. IT IS THE MOST FREQUENT GENETIC BLOOD DISORDER IN THE WORLD. ST. JUDE HAS ONE OF THE LARGEST PEDIATRIC SCD PROGRAMS IN THE COUNTRY AND PROVIDES COMPREHENSIVE TREATMENT AND EDUCATION TO ABOUT 900 CHILDREN WITH SCD IN THE GEOGRAPHIC CATCHMENT AREA. SCD IS DIAGNOSED BY STATE-WIDE NEWBORN SCREENING IN ALL 50 STATES. ST. JUDE HAS A PARTNERSHIP WITH NEWBORN SCREENING PROGRAMS IN TN AND MS THAT ENSURES A STABLE RELATIONSHIP AMONG PARENTS, PATIENTS, PRIMARY CARE PROVIDERS. ABOUT 50 NEWBORNS WITH SCD ARE IDENTIFIED EACH YEAR IN OUR GEOGRAPHIC CATCHMENT AREA. OUR SCD INFANT TODDLER PROGRAM CONTACTS AND ACCEPTS ALL CHILDREN DIAGNOSED WITH THE DISEASE IN OUR CATCHMENT AREA TO ITS COMPREHENSIVE CARE SERVICE. ADDITIONALLY, ST. JUDE PROVIDES TRAIT COUNSELING SERVICE TO INFANTS BORN WITH SICKLE CELL TRAIT TO 21 COUNTIES IN WESTERN TN. ST. JUDE PROVIDES CONFIRMATORY TESTING, EDUCATION AND COMPREHENSIVE CARE AND FOLLOW-UP THROUGHOUT CHILDHOOD FOR CHILDREN WITH SCD DISEASE. FROM BIRTH TO AGE 18 YEARS, PATIENTS ARE CLINICALLY EVALUATED AT LEAST EVERY 6 MONTHS, RECEIVE EDUCATION AND MULTI-DISCIPLINARY SERVICES ACCORDING TO STANDARDIZED TREATMENT AND EDUCATION GUIDELINES. SERVICES ALSO INCLUDE COMMUNITY OUTREACH AND EDUCATION OF THE LOCAL COMMUNITY. ST. JUDE HAS ESTABLISHED A FORMAL TRANSITION PROGRAM TO ADULT CARE FOR PATIENTS WITH SCD AND PROVIDES SUPPORT TO PATIENTS AND FAMILIES THROUGHOUT THE TRANSITION PROCESS BY WORKING CLOSELY WITH THE ADULT SCD PROGRAMS AT METHODIST UNIVERSITY HOSPITAL AND REGIONAL ONE HOSPITAL. ST. JUDE ALSO PROVIDES CLINICAL SERVICES FOR APPROXIMATELY 800 CHILDREN PER YEAR WITH OTHER NON-MALIGNANT HEMATOLOGICAL DISORDERS THROUGH A STRONG RELATIONSHIP WITH LOCAL COMMUNITY PHYSICIANS. CHILDREN FROM THE GEOGRAPHIC CATCHMENT AREA OF ST. JUDE WITH ILLNESSES SUCH AS HEMOPHILIA, APLASTIC ANEMIA, THROMBOSIS, THALASSEMIA, SPHEROCYTOSIS, AND IMMUNE THROMBOCYTOPENIC PURPURA AND OTHER NON-MALIGNANT HEMATOLOGIC DISORDERS ARE REFERRED TO AND RECEIVE STATE-OF THE-ART CARE FROM ST. JUDE PHYSICIANS AND MEDICAL STAFF. ST. JUDE IS ONE OF A SELECT GROUP OF FEDERALLY RECOGNIZED PEDIATRIC HEMOPHILIA TREATMENT CENTERS AND PROVIDES STATE-OF-THE-ART COMPREHENSIVE CARE TO APPROXIMATELY 300 CHILDREN WITH BLEEDING AND THROMBOSIS DISORDERS.IN ADDITION TO PROVIDING AND CONTINUOUSLY IMPROVING STANDARDIZED CARE TO THESE PATIENT POPULATIONS, ST. JUDE HEMATOLOGY DEDICATES SIGNIFICANT RESOURCES TO CLINICAL, TRANSLATIONAL, AND BASIC RESEARCH TO IMPROVE SURVIVAL AND DECREASE MORBIDITY OF CHILDREN WITH NON-MALIGNANT CHRONIC BLOOD DISEASES. MOST PATIENTS PARTICIPATE IN RESEARCH STUDIES, WHICH HAVE RESULTED IN MAJOR IMPROVEMENTS IN CLINICAL CARE. ST. JUDE IS PARTNERING WITH SEVERAL PHARMACEUTICAL AND BIOTECHNOLOGY COMPANIES TO PROVIDE ACCESS TO FIRST-IN-HUMAN GENETIC THERAPIES FOR SCD. ST. JUDE IS ALSO DEVELOPING SEVERAL NOVEL GENETIC THERAPIES TO CURE SCD. IN ADDITION, AN ONGOING CLINICAL TRIAL IS EVALUATING A NEW METHOD OF BONE MARROW TRANSPLANTATION FOR PATIENTS WITH SICKLE CELL DISEASE.(NOTE: THIS NARRATIVE FOR PART VI, LINE 2 IS CONTINUED BELOW) - SEE PAGE 86/115
PART VI, LINE 3:	NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. IN ADDITION, ST. JUDE PROVIDES AN UNPARALLELED LEVEL OF SUPPORT SERVICES AT NO COST TO FAMILIES. WE ALSO HAVE PROGRAMS TO ASSIST FAMILIES IN ENROLLING IN VARIOUS PUBLIC ASSISTANCE PROGRAMS FOR WHICH THEY MAY QUALIFY, INCLUDING BUT NOT LIMITED TO TENNCARE/MEDICAID, COVERKIDS, CHIPS AND SOCIAL SECURITY. FAMILIES ALSO HAVE ACCESS TO AN ONLINE EDUCATIONAL RESOURCE TITLED "YOU AND THE AFFORDABLE CARE ACT" (HTTPS://WWW.STJUDE.ORG/TREATMENT/PATIENT-RESOURCES/ CAREGIVER-RESOURCES/PATIENT-FAMILY-EDUCATION-SHEETS/LEGAL-FINANCIAL/YOU-AND-THE-AFFORDABLE-CARE-ACT.HTML). THIS ENSURES AN APPROPRIATE SAFETY NET SHOULD THE FAMILY SEEK TREATMENT OUTSIDE OF ST. JUDE AND IT ALLOWS US TO BE GOOD STEWARDS OF DONOR DOLLARS. WE UTILIZE AN OUTSIDE CONTRACTOR TO PROVIDE APPLICATION ASSISTANCE. THE HOSPITAL'S FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML) ARE POSTED ON THE HOSPITAL'S WEBSITE AND AVAILABLE AT REGISTRATION. THE DOCUMENTS ARE AVAILABLE IN ENGLISH AND SPANISH. FOR FAMILIES SPEAKING OTHER LANGUAGES, WE UTILIZE ONSITE INTERPRETER SERVICES AND/OR PROFESSIONAL CONTRACTED INTERPRETATION AND TRANSLATION SERVICES.
PART VI, LINE 4:	THE COMMUNITY SERVED BY ST. JUDE CAN BEST BE DEFINED BY THE ST. JUDE PATIENT POPULATION AND SCOPE OF CLINICAL SERVICES. ST. JUDE SERVES AS A NATIONAL REFERRAL CENTER FOR CHILDREN WITH CATASTROPHIC DISEASES, SUCH AS CANCER, AS WELL AS A LOCAL REFERRAL CENTER FOR CHILDREN WITH CANCER, BLOOD DISORDERS, HIV/AIDS, AND NEUROLOGICAL DISORDERS. IT DOES NOT ADMIT CHILDREN FOR ANY DIAGNOSES OUTSIDE OF THESE AREAS AND DOES NOT OFFER MEDICAL SERVICES BEYOND THOSE NECESSARY TO CARE FOR CHILDREN WITH THESE DISEASES. OUR CANCER PATIENTS COME FROM ALL OVER THE UNITED STATES AND ABROAD; HOWEVER, 65% OF THE NEW CANCER PATIENTS WE REGISTER RESIDE IN THE ST. JUDE CATCHMENT AREA, WHICH INCLUDES A 180-MILE RADIUS AROUND ST. JUDE LOCATED IN MEMPHIS, TN AND A 100-MILE RADIUS AROUND EACH OF OUR EIGHT AFFILIATES. THESE EIGHT AFFILIATES ARE IN HUNTSVILLE, AL, CHARLOTTE, NC, JOHNSON CITY, TN, BATON ROUGE, LA, SHREVEPORT, LA, TULSA, OK, SPRINGFIELD, MO, AND PEORIA, IL. THE CATCHMENT POPULATION IS GENERALLY CHARACTERIZED BY A HIGHER PROPORTION OF NON-HISPANIC BLACK/AFRICAN AMERICAN RACE, LOWER PROPORTION OF HISPANIC ETHNICITY, LOWER HOUSEHOLD INCOMES AND HOME VALUES, AND LOWER PROPORTION WITH AN EDUCATION BEYOND HIGH SCHOOL. APPROXIMATELY 4.9% OF THE POPULATION LIVE IN RURAL AREAS (BY RUCA CODE 10). TAKEN TOGETHER, THIS DIVERSE POPULATION INCLUDES MANY WITH LIMITED RESOURCES WHO ARE MEDICALLY UNDERSERVED. THROUGH ST. JUDE'S FOUNDING POLICY - THAT NO PATIENT BE DENIED TREATMENT BASED ON RACE, ETHNICITY, RELIGION, OR A FAMILY'S INABILITY TO PAY - AND WITH THE PROVISION OF RESOURCES TO OFFSET THE COSTS OF TRANSPORTATION AND HOUSING DURING CLINIC VISITS AND TREATMENT, WE REMOVE BARRIERS IN ACCESS TO OUR CUTTING-EDGE CLINICAL RESEARCH TRIALS AND EXCEPTIONAL CLINICAL CARE. ALL PEDIATRIC PATIENTS IN OUR CATCHMENT AREA ARE ACCEPTED TO ST. JUDE FOR TREATMENT OF THEIR CANCER.THE DEMOGRAPHICS OF THE PEDIATRIC CANCER POPULATION TREATED AT ST. JUDE CLOSELY MATCH THOSE OF OUR CATCHMENT AREA (BASED ON 2010 DATA FROM THE US CENSUS BUREAU) AND ALIGN WITH THE ESTIMATED INCIDENCE OF PEDIATRIC CANCER IN REPRESENTED RACIAL AND ETHNIC GROUPS (BASED ON SURVEILLANCE EPIDEMIOLOGY AND END RESULTS [SEER] 2009 DATA), CONFIRMING THAT ST. JUDE IS CLOSELY ALIGNED WITH THE NEEDS OF THE POPULATION IT SERVES. DEMOGRAPHICS FROM THE ST. JUDE PEDIATRIC CANCER COHORT ARE COMPARED WITH THE DEMOGRAPHICS OF THE CATCHMENT AREA ANNUALLY TO MONITOR DEMOGRAPHIC REPRESENTATION OF OUR CANCER PATIENTS IN RELATION TO THE AREA THAT WE SERVE. ST. JUDE ALSO OPERATES THE ST. JUDE GLOBAL INITIATIVE THROUGH GLOBAL PEDIATRIC MEDICINE (GPM), AIMED AT IMPROVING SURVIVAL RATES OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES WORLDWIDE. ST. JUDE ACCOMPLISHES THIS BY SHARING KNOWLEDGE, TECHNOLOGY AND ORGANIZATIONAL SKILLS, IMPLEMENTING NEW APPROACHES TO TREAT PEDIATRIC CANCER GLOBALLY, AND GENERATING INTERNATIONAL NETWORKS COMMITTED TO ERADICATING CANCER IN CHILDREN. ST. JUDE STRIVES TO ADDRESS THE NEEDS OF THOSE CHILDREN IN COUNTRIES THAT LACK SUFFICIENT RESOURCES AND HELP THEM MANAGE THEIR OWN BURDEN OF CASES EFFECTIVELY.THE ST. JUDE GLOBAL ALLIANCE IS A GLOBAL NETWORK ESTABLISHED TO PURSUE THE SHARED VISION OF IMPROVING THE QUALITY OF HEALTH CARE DELIVERY AND INCREASING SURVIVAL RATES OF CHILDREN WITH CANCER AND BLOOD DISORDERS WORLDWIDE. CURRENTLY, THE ALLIANCE HAS RECEIVED APPLICATIONS FROM 196 MEDICAL INSTITUTIONS IN 64 COUNTRIES WITH ESTABLISHED PARTNERSHIPS WITH 147 OF THE MEDICAL INSTITUTIONS IN 61 COUNTRIES. MEMBERS OF THE ALLIANCE ARE A PART OF A GLOBAL COMMUNITY DEDICATED TO TRANSFORMING GLOBAL CHILD HEALTH. THEY WILL HAVE THE OPPORTUNITY TO DEVELOP GLOBAL PROJECTS AND STUDIES, CONNECT WITH COMMITTEES AND WORKING GROUPS AT THE REGIONAL AND GLOBAL LEVEL, AND ENGAGE WITH ST. JUDE FACULTY AND STAFF FOR TRAINING AND DEVELOPMENT. ALLIANCE MEMBER INSTITUTIONS IN THE FOLLOWING COUNTRIES RECEIVE ADDITIONAL SUPPORT FROM ST. JUDE FOR PROJECT IMPLEMENTATION IN BRAZIL, CHILE, CHINA, DOMINICAN REPUBLIC, ECUADOR, EL SALVADOR, GUATEMALA, HAITI, HONDURAS, JORDAN, LEBANON, MEXICO, MOZAMBIQUE, NICARAGUA, PERU, PHILIPPINES, POLAND, SOUTH AFRICA, URUGUAY, UKRAINE, URUGUAY, VENEZUELA, ZAMBIA AND ZIMBABWE. ST. JUDE WORKS WITH ITS PARTNERS TO DEVELOP EVIDENCE-BASED TREATMENT PROTOCOLS TAILORED TO REGIONAL NEEDS AND RESOURCES. ADDITIONALLY, ST. JUDE'S PHYSICIANS AND NURSES SERVE AS MENTORS TO CLINICAL PERSONNEL AT PARTNER SITES, PROVIDE LOCAL AND ONLINE TRAINING FOR ONCOLOGY CARE, DIAGNOSIS, AND SUPPORTIVE CARE, AND PARTICIPATE IN ONLINE MEETINGS TO DISCUSS CLINICAL CARE BEST PRACTICES. MOST ONLINE MEETINGS AND TRAINING ARE PROVIDED VIA ST. JUDE'S WEB-BASED PLATFORM, ST. JUDE CURE4KIDSTM (C4K), A FREE RESOURCE FOR PEDIATRIC ONCOLOGY PROFESSIONALS, SCIENTISTS AND RESEARCHERS, REGARDLESS OF THEIR AFFILIATION WITH ST. JUDE OR ITS PARTNERS.ST. JUDE IS ALSO A RESEARCH ORGANIZATION, WITH RESEARCH COVERING A BROADER SCOPE OF HEALTH ISSUES THAN THE DISEASES TREATED AS A PRIMARY DIAGNOSIS.
PART VI, LINE 5:	INSTITUTION OVERVIEWST. JUDE CHILDREN'S RESEARCH HOSPITAL WAS OPENED IN 1962. OUR MISSION IS TO ADVANCE CURES, AND MEANS OF PREVENTION, FOR PEDIATRIC CATASTROPHIC DISEASES THROUGH RESEARCH AND TREATMENT. CONSISTENT WITH THE VISION OF OUR FOUNDER, DANNY THOMAS, NO CHILD IS DENIED TREATMENT BASED ON RACE, RELIGION OR A FAMILY'S INABILITY TO PAY. OUR VISION IS TO BE THE WORLD LEADER IN ADVANCING THE TREATMENT AND PREVENTION OF CATASTROPHIC DISEASES IN CHILDREN. THIS VISION IS PURSUED BY PROVIDING OUTSTANDING PATIENT CARE; BY CONDUCTING BASIC, TRANSLATIONAL AND CLINICAL RESEARCH DESIGNED TO ELUCIDATE BIOLOGICAL MECHANISMS, UNDERSTAND DISEASE PATHOGENESIS, IMPROVE DIAGNOSIS, ENHANCE TREATMENT OUTCOME, PREVENT DISEASES AND MINIMIZE ADVERSE CONSEQUENCES OF TREATMENT; AND BY EDUCATING HEALTH CARE AND SCIENTIFIC RESEARCH PROFESSIONALS. THROUGH THESE EFFORTS, WE SEEK TO CURE AND ENHANCE THE QUALITY OF LIFE FOR AN INCREASING NUMBER OF CHILDREN WHO COME TO US FOR TREATMENT BY EXPANDING AND SHARING KNOWLEDGE TO ADVANCE TREATMENT OF CHILDREN WITH CATASTROPHIC DISEASES WORLDWIDE, WHILE DEVELOPING STRATEGIES TO PREVENT CATASTROPHIC DISEASES IN CHILDREN. WE ARE THE ONLY NCI-DESIGNATED CANCER CENTER SOLELY DEDICATED TO CHILDREN.ST. JUDE COMBINES LABORATORY AND CLINICAL RESEARCH TO ADVANCE THE CARE OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES. ST. JUDE IS COMMITTED TO LEVERAGING ITS ASSETS TO ACCELERATE PROGRESS AND MAXIMIZE IMPACT FOR CHILDREN IN MEMPHIS AND AROUND THE GLOBE WITH AN ACUTE FOCUS ON FUNDAMENTAL SCIENCE, CHILDHOOD CANCER, PEDIATRIC CATASTROPHIC DISEASES, GLOBAL IMPACT, AND WORKFORCE AND ENVIRONMENT. ST. JUDE HAS AND WILL CONTINUE TO SIGNIFICANTLY INFLUENCE THE WAY THE WORLD UNDERSTANDS AND TREATS CHILDHOOD CANCER, SICKLE CELL DISEASE, NEUROLOGICAL DISORDERS, AND INFECTIOUS DISEASES. THE ST. JUDE ENVIRONMENT FACILITATES INTERACTION AMONG LABORATORY SCIENTISTS AND CLINICAL INVESTIGATORS, PROMOTING THE TRANSLATION OF NEW FINDINGS FROM THE LAB TO THE CLINIC AND COMMUNICATING CLINICAL PROBLEMS TO LABORATORY SCIENTISTS FOR FURTHER INVESTIGATION. OUR 22 ACADEMIC DEPARTMENTS ARE HOME TO MORE THAN 120 FUNDAMENTAL AND TRANSLATIONAL RESEARCH LABS THAT BRING THE 'BENCH TO THE BEDSIDE,' ENSURING THAT PATIENTS TREATED AT ST. JUDE FULLY BENEFIT FROM ADVANCES IN OUR UNDERSTANDING OF PEDIATRIC CATASTROPHIC DISEASE AND THEIR TREATMENT.HOSPITAL OPERATIONS ARE OVERSEEN BY A BOARD OF GOVERNORS, MOST OF WHICH ARE NEITHER EMPLOYEES, INDEPENDENT CONTRACTORS, NOR THEIR FAMILY MEMBERS. RESEARCH ACTIVITIES ARE REVIEWED ANNUALLY BY A SCIENTIFIC ADVISORY BOARD COMPOSED OF INTERNATIONALLY PROMINENT PHYSICIANS AND SCIENTISTS. AN INSTITUTIONAL REVIEW BOARD, OR IRB, WHICH IS A GROUP OF SCIENTISTS, DOCTORS, OR OTHER HEALTH CARE PROFESSIONALS, REVIEWS EVERY NEW CLINICAL RESEARCH STUDY AT THE HOSPITAL BEFORE IT BEGINS.THE PRIMARY FUNDRAISING SOURCE FOR ST. JUDE IS ALSAC (AMERICAN LEBANESE AND SYRIAN ASSOCIATED CHARITIES), WHICH RAISES FUNDS SOLELY FOR THE HOSPITAL. BECAUSE OF THE HOSPITAL'S MISSION, PEOPLE NATIONWIDE CONTRIBUTE VIA TENS OF THOUSANDS OF FUNDRAISING EFFORTS. ALSAC CONTRIBUTED $997 MILLION IN FY22 TO SUPPORT ST. JUDE.FINDING CURES AND SAVING CHILDREN REMAINS AT THE FOREFRONT OF ALL WE DO. OUR FACULTY AND STAFF KNOW ALL TOO WELL THAT CANCER AND OTHER DEADLY ILLNESSES DON'T STOP, EVEN IN THE MIDST OF A PANDEMIC AND UPHEAVAL ON THE WORLD STAGE. AS A RESULT, WE CONTINUE TO CARE FOR THOUSANDS OF CHILDREN WITH CANCER AND OTHER LIFE-THREATENING DISEASES. WE ARE FOCUSED ON ENSURING PATIENTS GET THE TREATMENT THEY NEED AND UNDERSTANDING THE SCIENTIFIC FOUNDATION THROUGH BASIC AND TRANSLATIONAL RESEARCH, CLINICAL TRIALS, AND POPULATION SCIENCE FOCUSED ON CATASTROPHIC CHILDHOOD DISEASES AND SURVIVORSHIP. (NOTE: THIS NARRATIVE FOR PART VI, LINE 5 IS CONTINUED BELOW) - SEE PAGE 87/115
PART VI, LINE 2 (CONTINUATION FROM 80/115)	HIVTHE CONNECT TO PROTECT (C2P) COMMUNITY COALITION LED BY MEMBERS OF THE HOSPITAL'S COMPREHENSIVE HIV PREVENTION AND TREATMENT PROGRAM FOR CHILDREN AND YOUTH, HAS SIGNIFICANTLY CONTRIBUTED TO THE STRONG COMMUNITY TIES THAT ST. JUDE HAS ESTABLISHED AND STRENGTHENED. LAUNCHED IN 2008, C2P IS MADE UP OF 25 PARTNER AGENCIES REPRESENTING A DIVERSE MIX OF STAKEHOLDERS FROM VARIOUS SECTORS IN MEMPHIS. THIS INCLUDES THE HEALTH DEPARTMENT, FAITH-AND COMMUNITY-BASED ORGANIZATIONS, SCHOOLS, BUSINESSES, YOUTH, AND HEALTH CARE ORGANIZATIONS; ALL ALIGNED WITH THE COMMON GOAL OF OPTIMIZING HIV PREVENTION AND TREATMENT. THE STRENGTH OF THIS COALITION HAS BEEN TO PROVIDE A NON-THREATENING, COLLABORATIVE ENVIRONMENT WHERE INDIVIDUALS AND AGENCIES WITH DIFFERENT BACKGROUNDS AND PRIORITIES HAVE BEEN ABLE TO COLLABORATIVELY IMPLEMENT OVER 70 NEW POLICIES, PRACTICES AND PROGRAMS THAT IMPACT HIV PREVENTION AND TREATMENT IN YOUTH. IN THIS COALITION, WE HAVE LEARNED AND SHARED BEST PRACTICES, RESEARCH METHODOLOGIES, AND TOGETHER, IDENTIFIED AND DEVELOPED NEW STRUCTURAL CHANGE OBJECTIVES TO ADDRESS IMPEDIMENTS THAT PREVENT YOUTH FROM MOVING ALONG THE HIV PREVENTION AND TREATMENT CARE CONTINUUM. WITHIN THIS 2022 FISCAL YEAR AND WORKING IN THE MIDST OF THE PANDEMIC, STAFF PIVOTED FROM IN-PERSON TO VIRTUAL MEETING PLATFORM AND COORDINATED AND HOSTED MULTIPLE C2P VIRTUAL MEETINGS FOR THE 25 MEMBER ORGANIZATIONS OF THE CONNECT TO PROTECT (C2P) COMMUNITY COALITION. THE HIV PREVENTION AND TREATMENT PROGRAM VALUES THE STRONG AND BI-DIRECTIONAL COLLABORATION WITH COLLEAGUES IN THE COMMUNITY. WITH A SHARED FOCUS, WE HAVE BEEN ABLE TO ACHIEVE LINKAGE TO CARE, RETENTION IN CARE AND PREP EFFORTS, THROUGH COMMUNITY AGENCY BUY-IN AND SUPPORT.
PART VI, LINE 5 (CONTINUATION FROM PAGE 86/115)	FACILITIESFOR FY22, ST. JUDE ANNOUNCED AN EXPANSION OF ITS SIX-YEAR STRATEGIC PLAN THAT WILL NOW COMMIT $12.9 BILLION TO SUPPORT 2,300 JOBS AND INCREASE FUNDS FOR CONSTRUCTION, RENOVATION AND CAPITAL NEEDS. THE NEW FUNDING WILL AFFECT SCIENTIFIC OPERATIONS, CLINICAL CARE, GLOBAL MEDICINE AND INFRASTRUCTURE. THE EXPANSION WILL INCLUDE CONSTRUCTION OF TWO, 15-STORY TOWERS DEDICATED TO PATIENT CARE AND CLINICAL RESEARCH. A NEW HOUSING COMPLEX IS UNDER CONSTRUCTION AS IS A 45,000SF TREATMENT-AND-STAFF-FREE FLOOR AT THE HOSPITAL WHERE PATIENTS AND THEIR FAMILIES CAN GATHER, RELAX, ATTEND SCHOOL, PLAY MUSIC, NAP, OR GRAB A CUP OF COFFEE IN BETWEEN CLINIC APPOINTMENTS.LASTLY, TO ENHANCE THE PATIENT EXPERIENCE AT ST. JUDE, THE INSTITUTION HAS CREATED IN PARTNERSHIP WITH THE MEMPHIS-SHELBY COUNTY AIRPORT AUTHORITY, A PRIVATE, COMFORTABLE SPACE FOR PATIENTS AND THEIR FAMILIES TO WAIT FOR THEIR FLIGHT OR TRANSPORTATION TO THE CAMPUS. THESE PROJECTS FOLLOW THE 2021 OPENING OF THE INSPIRATION4 ADVANCED RESEARCH CENTER THAT WILL ACCOMMODATE UP TO 1,000 EMPLOYEES FOCUSED ON TRANSFORMATIVE SCIENCE. THE STRUCTURE IS DESIGNED FOR COLLABORATION ACROSS MANY SCIENTIFIC FIELDS, INCLUDING DEVELOPMENTAL NEUROBIOLOGY, IMMUNOLOGY, CELL AND MOLECULAR BIOLOGY, GENE EDITING, METABOLOMICS, ADVANCED MICROSCOPY, EPIGENETICS AND GENOMICS. IT IS ALSO HOME SO SPECIALIZED TECHNOLOGY FOR CONDUCTING COMPUTATIONAL BIOLOGY, USING ARTIFICIAL INTELLIGENCE, GENE EDITING AND ANALYZING CELL SAMPLES VIA SOME OF THE WORLD'S MOST ADVANCED MICROSCOPES. A BIOREPOSITORY ON SITE CONTAINS TUMOR SAMPLES FOR SHARING WITH RESEARCHERS AROUND THE WORLD.THESE INVESTMENTS ARE PART OF A RICH HISTORY. ST. JUDE CONTRIBUTED TO THE BUILDING OF A STATE-OF-THE ART NEUROSURGICAL FACILITY FOR TREATING LOCAL PEDIATRIC PATIENTS AND ST. JUDE BRAIN TUMOR PATIENTS. THE FACILITY IS EQUIPPED WITH INTRA-OPERATIVE IMAGING EQUIPMENT (IMRI). WHEN PURCHASED, ONLY TWO NEUROSURGICAL FACILITIES IN THE UNITED STATES PROVIDED PATIENTS WITH THIS LEVEL OF TREATMENT, WHICH ALLOWS IMAGING TO TAKE PLACE DURING SURGICAL PROCEDURES. IMRI EQUIPMENT ALLOWS SURGEONS TO MAKE INFORMED DECISIONS DURING THE SURGERY. LIVE WEB CASTS ALLOW OTHERS TO VIEW PROCEDURES. OUR ASSISTANCE WITH THIS FACILITY HELPS ASSURE THAT CHILDREN IN THE AREA HAVE ACCESS TO THE BEST NEUROSURGICAL TREATMENT AVAILABLE.THE CYCLOTRON (PARTICLE ACCELERATOR) AT ST. JUDE ENABLES RESEARCHERS TO TRACK THE GROWTH OF CANCER CELLS, PINPOINT THE PRODUCTION OF NEW DNA BY TUMOR CELLS AND STUDY THE HEARTS OF ADULT CHILDHOOD CANCER SURVIVORS RETURNING TO ST. JUDE FOR LIFETIME FOLLOW-UP. THE CYCLOTRON HELPS RESEARCHERS BETTER UNDERSTAND CHILDHOOD CANCER BY ENABLING THEM TO PRODUCE NEW, VERY SHORT-ACTING TRACERS.ST. JUDE USES THE SERVICES OF CHILDREN'S GMP, LLC (OF WHICH ST. JUDE IS THE SOLE MEMBER). CHILDREN'S GMP, LLC, MANAGES AND OPERATES A GOOD MANUFACTURING PRACTICE (GMP) FACILITY THAT ENGAGES IN THE PRODUCTION OF BIOLOGICS AND DRUGS FOR RESEARCH. THE GMP OFFERS RESOURCES TO STUDY RARE DISEASES OVERLOOKED BY PHARMACEUTICAL COMPANIES BECAUSE THERE IS LITTLE PROFIT IN MANUFACTURING DRUGS FOR LESSER-KNOWN DISEASES. THE FACILITY, OPERATING ACCORDING TO APPROVED FDA STANDARDS, ALLOWS DOCTORS TO TAILOR TREATMENTS SPECIFICALLY FOR AN INDIVIDUAL CHILD.THE CELL AND TISSUE IMAGING CENTER INCLUDES ELECTRON MICROSCOPY AND LIGHT MICROSCOPY. THE FACILITY PROVIDES INVESTIGATORS ACCESS TO TRANSMISSION ELECTRON MICROSCOPY, CONFOCAL LASER SCANNING MICROSCOPY, MULTIPHOTON MICROSCOPY, IMAGE ANALYSIS, CELL MICROINJECTION AND LIVE CELL IMAGING. THE FEI TECNAI 20 200KV FEG ELECTRON MICROSCOPE, WHICH CAN MAGNIFY AN OBJECT 700,000 TIMES, IS AT THE HEART OF THIS PROGRAM. THIS TECHNOLOGY ALLOWS RESEARCHERS TO GET A CLOSER LOOK AT CANCER TO BETTER UNDERSTAND HOW IT GROWS AND SPREADS AND RESPONDS TO THERAPY. USING THE ELECTRON MICROSCOPE, RESEARCHERS LEARN HOW CANCER CELLS BREAK AWAY FROM THE TUMOR AND SPREAD THROUGHOUT THE BODY.ST. JUDE IS HOME TO THE ONLY PROTON BEAM RADIATION THERAPY CENTER DEVOTED SOLELY TO TREATING CHILDREN WITH BRAIN TUMORS AND SEVERAL OTHER CHILDHOOD CANCERS. PROTON THERAPY, WHICH IS LESS DAMAGING TO SURROUNDING HEALTHY TISSUE THAN OTHER CURRENT RADIATION THERAPIES, ENABLES ST. JUDE TO PROVIDE RADIATION IN A MORE INTEGRATED MANNER TO OUTPATIENTS AND ALLOWS RADIATION ONCOLOGISTS TO LEAD THE DEVELOPMENT OF NEW TREATMENTS.
RESEARCH	ST. JUDE SCIENTISTS CONTINUED TO TRAVEL THEIR PATH OF INNOVATION, MAKING DISCOVERIES AND SHARING THEIR FINDINGS WITH THE WORLD. IN 2022, ST. JUDE LEAD AUTHORS PUBLISHED 115 HIGH-IMPACT (>10) PEER REVIEWED PAPERS. THE ARTICLES FOCUSED ON A BROAD SWATH OF BASIC AND CLINICAL RESEARCH. SOME HIGHLIGHTS INCLUDE:CANCER SURVIVORSHIP IN THE ERA OF BIG DATA. ST. JUDE IS A POWERHOUSE WHEN IT COMES TO LEVERAGING VAST AMOUNTS OF DATA TO BETTER UNDERSTAND CANCER. THAT POWER, COMBINED WITH FIELD LEADING EXPERTISE IN SURVIVORSHIP AND ACCESS TO THE WORLD'S FINEST COLLECTIONS OF SURVIVORSHIP DATA THROUGH ST. JUDE LIFE AND THE CHILDHOOD CANCER SURVIVORS STUDY HAS SET ST. JUDE UP TO MAKE DISCOVERIES ABOUT THE HEALTH AND LIVES OF CHILDHOOD CANCER SURVIVORS THAT COULD NOT BE MADE ANYWHERE ELSE. RESEARCH IN 2022 HAS DUG INTO ISSUES SUCH AS ANCESTRY AND INHERITED RISK, SOCIOECONOMIC DISPARITIES, AND MORE USING LARGE-SCALE DATA ANALYSIS AND INFORMATICS. (LEE ET AL, JAMA ONCOLOGY, 3/1/22; DONG ET AL, GENOME MED, 3/22/22; WILLIAMS ET AL, BLOOD, 5/19/22; SAPKOTA ET AL, NATURE MED, 8/1/22; IM ET AL, CANCER RESEARCH 8/16/23; SHIN ET AL, J CLIN ONC, 9/27/22; SONG ET AL, CANCER COMMUN, 10/18/22; WANG ET AL, CANCER RES, 11/10/22)GENE REGULATION: THE NEXT FRONTIER OF DISCOVERY IN PEDIATRIC CANCER. ST. JUDE LED THE CHARGE TO UNDERSTAND THAT GENETICS OF PEDIATRIC CANCER THROUGH THE PEDIATRIC CANCER GENOME PROJECT (PCGP). WHILE MUCH WAS LEARNED FROM THE PCGP, ONE OF THE MAIN LEARNINGS WAS THAT PEDIATRIC CANCER IS INCREDIBLY COMPLEX, AND MANY ABNORMALITIES AND MUTATIONS LIE IN PLACES WITHIN THE GENOME THAT ARE TIED TO ENHANCER AND SUPER-ENHANCER BIOLOGY AND NON-CODING GENOME REGULATION. SCIENTISTS AT ST. JUDE ARE ONCE AGAIN ON THE LEADING EDGE OF DISCOVERY, DIGGING THROUGH THE BIOLOGY OF CANCER CELLS TO UNDERSTAND HOW GENES ARE CONTROLLED AND EXPRESSED AND IDENTIFY POTENTIAL VULNERABILITIES AND WEAKNESSES THAT CAN BE EXPLOITED BY THERAPY. (YANG ET AL, NAT GENET, 2/1/22; DURBIN ET AL, CANCER DISCOVERY, 3/1/22; CHANDRA ET AL, CANCER DISC, 4/1/22; FLASCH ET AL, ACTA NEUROPATH, 5/1/22; HETZEL ET AL, NATURE CANCER, 6/1/22; FLERLAGE ET AL, BLOOD, 8/17/22; HU ET AL, SCI TRANS MED, 8/24/22; ZHAO ET AL, J NCI, 9/9/22; ZHAO ET AL, NAT COMMUN, 9/14/22)CAR T CELLS: ENGINEERING A BREAKTHROUGH. THERE IS TREMENDOUS MOMENTUM BEHIND THE IDEA OF MODULATING THE IMMUNE SYSTEM TO ATTACK CANCER, WITH GREAT SUCCESS ALREADY DEMONSTRATED IN SOME SETTINGS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS. YET THE TRUE PROMISE OF CAR T CELLS HAS YET TO BE REALIZED, ESPECIALLY IN DISEASES LIKE AML, SOLID TUMORS AND BRAIN TUMORS. SCIENTISTS AT ST. JUDE ARE LEADING THE CHARGE TO UNDERSTAND THE FUNDAMENTAL BIOLOGY OF CAR T CELLS, IDENTIFY THE OPTIMAL TARGETS AND DESIGN AND ENGINEER THE NEXT GENERATION OF CAR T CELLS FOR THESE HARDER TO TREAT TYPES OF PEDIATRIC CANCER. (HEBBAR ET AL, NAT COMMUN, 1/31/22; VAIDYA ET AL, HAEMATOLOGICA, 7/28/22; FREIWAN ET AL, BLOOD, 8/1/22; CARNEVALE ET AL, NATURE, 9/1/22; WILSON ET AL, CANCER DISC, 9/2/22)RETHINKING THE ROLE OF RADIATION THERAPY. RADIATION IS A CORNERSTONE OF CARE FOR MANY TYPES OF PEDIATRIC CANCER. WHILE THERE HAS BEEN A TREMENDOUS AMOUNT OF RESEARCH AROUND HOW TO GIVE RADIATION SAFELY AND OPTIMIZE RESULTS, SCIENTISTS AT ST. JUDE ARE SETTING THE GOLD STANDARD WHEN IT COMES TO STUDYING AND UNDERSTANDING RADIATION THERAPY, DEMONSTRATING ITS IMPORTANCE FOR THERAPY, AND PROVIDING FIELD-SHAPING RECOMMENDATIONS ABOUT HOW TO BEST USE THIS THERAPY. RESEARCHERS HAVE PARTICULARLY FOCUSED ON DIFFICULT TO TREAT AND RARE DISEASES SUCH AS CRANIOPHARYNGIOMA, DEMONSTRATING HOW RADIATION THERAPY CAN HELP DRIVE CURE RATES. (EDMONSTON ET AL, NEURO ONCOL, 12/1/22; MERCHANT ET AL, NEURO ONCOL, 12/1/22; JACOLA ET AL, J CLIN ONCOL, 11/2/22; LIU ET AL, ACTA NEUROPATH, 10/1/22; LUCAS ET AL, NEURO ONC, 7/1/22; ACAHRYA ET AL, J CLIN ONC, 1/1/22)LEVERAGING TECHNOLOGY TO UNDERSTAND BIOLOGICAL STRUCTURE AND FUNCTION. ST. JUDE HAS BUILT INFRASTRUCTURE TO CONDUCT RESEARCH THAT LOOKS AT THE BIOLOGIC STRUCTURE OF PROTEINS AND MOLECULES AT THE MOST INTRICATE, DETAILED LEVELS. WITH TECHNIQUES SUCH AS SINGLE-MOLECULE IMAGING LEADING THE FOREFRONT OF TECHNOLOGICAL INNOVATION, AND MAINSTAYS LIKE CRYO-EM CONTINUING TO PUSH THE ENVELOPE, SCIENTISTS AT ST. JUDE ARE CONTINUALLY MAKING DISCOVERIES THAT SHAPE OUR UNDERSTANDING OF THE MOST FUNDAMENTAL BIOLOGIC PROCESSES. (ASHER ET AL, CELL, 5/12/22; YE ET AL, MOL CELL, 7/7/22; STACHOWSKI ET AL, ANGEW CHEM INT, 8/1/22; UGOLINI ET AL, MOL CELL, 11/16/22; SANDHU ET AL, NAT COMMUN, 12/2/22)

Schedule H (Form 990) 2021

Additional Data

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Schedule I
(Form 990)

Department of the Treasury
Internal Revenue Service

Grants and Other Assistance to Organizations,
Governments and Individuals in the United States

Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet

Attach to Form 990.
lBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization
ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number
62-0646012

Part I

General Information on Grants and Assistance

Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................

Yes No

Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.

Part II

Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient

that received more than $5,000. Part II can be duplicated if additional space is needed.

(a) Name and address of organization or government	(b) EIN	(c) IRC section (if applicable)	(d) Amount of cash grant	(h) Purpose of grant or assistance
(1) CHURCH HEALTH 1350 CONCOURSE AVE STE 142 MEMPHIS,TN38104	58-1716113	501(C)(3)	115,750	FINANCIAL SUPPORT
(2) CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER 3333 BURNET AVE CINCINNATI,OH45229	31-0833936	501(C)(3)	10,000	FINANCIAL SUPPORT
(3) MID-SOUTH MINORITY BUSINESS COUNCIL 158 MADISON AVE STE 300 MEMPHIS,TN38103	62-1198163	501(C)(6)	6,850	SPONSORSHIP

Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image

Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50055P

Schedule I (Form 990) 2021

Page 2

Part III

Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.

(a) Type of grant or assistance	(b) Number of recipients	(c) Amount of cash grant	(d) Amount of noncash assistance	(e) Method of valuation (book, FMV, appraisal, other)	(f) Description of noncash assistance

(1)
(2)
(3)
(4)
(5)
(6)
(7)

Part IV

Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.

Return Reference	Explanation
PART I, LINE 2:	ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS ACTIVELY INVOLVED WITH THE DONEE. THROUGH THIS ACTIVE INVOLVEMENT, THE ORGANIZATIONS ARE MONITORED TO ENSURE THE SUPPORT IS USED APPROPRIATELY.

Schedule I (Form 990) 2021

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Schedule J
(Form 990)

Department of the Treasury
Internal Revenue Service

Compensation Information

For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet

Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet

Attach to Form 990.
SchJMediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Questions Regarding Compensation

Yes

Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.

First-class or charter travel Housing allowance or residence for personal use

Travel for companions Payments for business use of personal residence

Tax idemnification and gross-up payments Health or social club dues or initiation fees

Discretionary spending account Personal services (e.g., maid, chauffeur, chef)

If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .....

Yes

Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ....

Yes

Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.

Compensation committee Written employment contract

Independent compensation consultant Compensation survey or study

Form 990 of other organizations Approval by the board or compensation committee

During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:

Receive a severance payment or change-of-control payment? .............

Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........

Yes

Participate in, or receive payment from, an equity-based compensation arrangement? .........

If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.

Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:

The organization? ....................

Any related organization? .......................

If "Yes," on line 5a or 5b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:

The organization? ..................

Any related organization? ......................

If "Yes," on line 6a or 6b, describe in Part III.

For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............

Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................

If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50053T

Schedule J (Form 990) 2021

Page 2

Part II

Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.

For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.

(A) Name and Title		(B) Breakdown of W-2, 1099-MISC compensation, and/or 1099-NEC			(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)	(F) Compensation in column (B) reported as deferred on prior Form 990
(A) Name and Title		(i) Base compensation	(ii) Bonus & incentive compensation	(iii) Other reportable compensation	(C) Retirement and other deferred compensation	(D) Nontaxable benefits	(E) Total of columns (B)(i)-(D)
1DAVID ELLISON CHAIR	(i) (ii)	803,464 ------------- 0	18,200 ------------- 0	1,044,054 ------------- 0	31,900 ------------- 0	17,537 ------------- 0	1,915,155 ------------- 0	85,562 ------------- 0
2JAMES R DOWNING PRESIDENT/CEO	(i) (ii)	1,193,948 ------------- 0	50,200 ------------- 0	8,931 ------------- 0	266,424 ------------- 0	26,869 ------------- 0	1,546,372 ------------- 0	0 ------------- 0
3ELLIS NEUFELD EVP/CLINICAL DIRECTOR	(i) (ii)	837,725 ------------- 0	200 ------------- 0	442,350 ------------- 0	73,239 ------------- 0	29,800 ------------- 0	1,383,314 ------------- 0	225,000 ------------- 0
4THOMAS E MERCHANT CHAIR	(i) (ii)	866,797 ------------- 0	18,200 ------------- 0	103,719 ------------- 0	206,180 ------------- 0	37,134 ------------- 0	1,232,030 ------------- 0	0 ------------- 0
5ZOLTAN PATAY CHAIR	(i) (ii)	769,200 ------------- 0	18,200 ------------- 0	306,457 ------------- 0	48,740 ------------- 0	26,869 ------------- 0	1,169,466 ------------- 0	0 ------------- 0
6ANDREW DAVIDOFF CHAIR	(i) (ii)	838,146 ------------- 0	18,200 ------------- 0	78,338 ------------- 0	154,387 ------------- 0	34,575 ------------- 0	1,123,646 ------------- 0	0 ------------- 0
7RICHARD C SHADYAC JR EX-OFFICIO DIRECTOR	(i) (ii)	0 ------------- 892,368	0 ------------- 0	0 ------------- 65,630	0 ------------- 111,999	0 ------------- 21,668	0 ------------- 1,091,665	0 ------------- 60,878
8CHARLES M ROBERTS EVP/DIRECTOR CANCER CENTER	(i) (ii)	885,884 ------------- 0	200 ------------- 0	2,641 ------------- 0	164,479 ------------- 0	13,969 ------------- 0	1,067,173 ------------- 0	0 ------------- 0
9RANDALL T HAYDEN FACULTY	(i) (ii)	450,553 ------------- 0	18,200 ------------- 0	496,642 ------------- 0	53,042 ------------- 0	13,813 ------------- 0	1,032,250 ------------- 0	0 ------------- 0
10CARLOS RODRIGUEZ-GALINDO EVP/CHAIR	(i) (ii)	735,361 ------------- 0	200 ------------- 0	3,673 ------------- 0	140,234 ------------- 0	12,372 ------------- 0	891,840 ------------- 0	0 ------------- 0
11PATRICIA A KEEL EVP, CAO & CFO	(i) (ii)	733,724 ------------- 0	200 ------------- 0	5,074 ------------- 0	82,615 ------------- 0	10,649 ------------- 0	832,262 ------------- 0	0 ------------- 0
12JAMES I MORGAN EVP/SCIENTIFIC DIRECTOR (THRU 04/22)	(i) (ii)	568,495 ------------- 0	75,200 ------------- 0	6,986 ------------- 0	31,900 ------------- 0	28,846 ------------- 0	711,427 ------------- 0	0 ------------- 0
13JOSEPH P TAYLOR EVP/SCIENTIFIC DIRECTOR (BEG 04/22)	(i) (ii)	129,575 ------------- 0	0 ------------- 0	21,037 ------------- 0	0 ------------- 0	0 ------------- 0	150,612 ------------- 0	0 ------------- 0

Schedule J (Form 990) 2021

Page 3

Part III

Supplemental Information

Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.

Return Reference	Explanation
PART I, LINE 1A	CHARTER TRAVEL: ONE OFFICER TRAVELED ONCE ON HOSPITAL BUSINESS BY CHARTER. CHARTER FLIGHT WAS NECESSITATED BY COVID, AND PRE-APPROVED BY THE BOARD CHAIR. TRAVEL EXPENSES ARE REIMBURSED UNDER AN ACCOUNTABLE PLAN AND ARE NOT RECORDED AS COMPENSATION. TAX INDEMNIFICATION AND GROSS-UP PAYMENTS: A PAYMENT WAS ISSUED FOR DEPENDENT TUITION FOR ONE OFFICER AND ONE HIGHEST COMPENSATED EMPLOYEE. THE APPLICABLE EXPENSE WAS GROSSED-UP AND INCLUDED IN THE EMPLOYEE'S W-2 AS ADDITIONAL TAXABLE COMPENSATION.
PART I, LINE 4B:	THE ORGANIZATION ESTABLISHED A NON-QUALIFIED DEFERRED COMPENSATION PLAN PURSUANT TO CODE SECTION 457(F) OF THE INTERNAL REVENUE CODE. THE PLAN AMOUNTS ARE SUBJECT TO SUBSTANTIAL FUTURE SERVICE REQUIREMENTS TO THE ORGANIZATION AND ARE SUBJECT TO SUBSTANTIAL RISK OF FORFEITURE. NONQUALIFIED PLAN PAYMENTS WERE MADE DURING THE YEAR TO THE FOLLOWING LISTED PERSON IN PART VII: DAVID ELLISON: $1,035,264 RICHARD C. SHADYAC, JR. $60,878
SCHEDULE J, PART II:	RICHARD C. SHADYAC, JR. SERVES AS AN EX-OFFICIO VOTING DIRECTOR OF THE BOARD OF ST. JUDE. MR. SHADYAC IS EMPLOYED AS AN OFFICER OF ALSAC, A RELATED ORGANIZATION TO ST. JUDE. THE COMPENSATION SHOWN IN COLUMNS (B), (C), (D) AND (E) WAS PAID TO MR. SHADYAC BY ALSAC FOR HIS DUTIES AS CEO OF ALSAC.

Schedule J (Form 990) 2021

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Schedule L
(Form 990)

Department of the Treasury
Internal Revenue Service

Transactions with Interested Persons

Complete if the organization answered "Yes" on Form 990, Part IV, lines 25a, 25b, 26, 27, 28a, 28b, or 28c, or Form 990-EZ, Part V, line 38a or 40b.
MediumBullet

Attach to Form 990 or Form 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Excess Benefit Transactions (section 501(c)(3), section 501(c)(4), and section 501(c)(29) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.

1(a) Name of disqualified person	(c) Description of transaction	(d) Corrected?
1(a) Name of disqualified person	(c) Description of transaction	Yes	No

Enter the amount of tax incurred by the organization managers or disqualified persons during the year under section 4958. ........................... Bullet Image

Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ........ Bullet Image

Part II

Loans to and/or From Interested Persons.
Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a, or Form 990, Part IV, line 26; or if the organization reported an amount on Form 990, Part X, line 5, 6, or 22

(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	(d) Loan to or from the organization?		(e) Original principal amount	(f) Balance due	(g) In default?		(h) Approved by board or committee?		(i) Written agreement?
(a) Name of interested person	(b) Relationship with organization	(c) Purpose of loan	To	From	(e) Original principal amount	(f) Balance due	Yes	No	Yes	No	Yes	No






Total ............... $

Part III

Grants or Assistance Benefiting Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 27.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of assistance	(d) Type of assistance	(e) Purpose of assistance

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 50056A

Schedule L (Form 990) 2021

Page 2

Part IV

Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.

(a) Name of interested person	(b) Relationship between interested person and the organization	(c) Amount of transaction	(d) Description of transaction	(e) Sharing of organization's revenues?
(a) Name of interested person		(c) Amount of transaction	(d) Description of transaction	Yes	No
(1) SUSANNA DOWNING	SEE PART V	82,430	EMPLOYMENT		No
(2) DIANE ROBERTS	SEE PART V	287,113	EMPLOYMENT		No
(3) CHRISTOPHER ROBERTS	SEE PART V	23,190	EMPLOYMENT		No
(4) LYNN RODRIGUEZ	SEE PART V	173,313	EMPLOYMENT		No
(5) MONDIRA KUNDU	SEE PART V	108,977	EMPLOYMENT		No

Part V

Supplemental Information
Provide additional information for responses to questions on Schedule L (see instructions).

Return Reference	Explanation
SCHEDULE L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:	(A) NAME OF INTERESTED PERSON: SUSANNA DOWNING(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION: FAMILY MEMBER OF PRESIDENT AND CEO, JAMES R. DOWNING.(C) AMOUNT OF TRANSACTION: $82,430(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT(E) SHARING OF ORGANIZATION REVENUES? = NO
SCHEDULE L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:	(A) NAME OF INTERESTED PERSON: DIANE ROBERTS(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION: FAMILY MEMBER OF OFFICER, CHARLES M. ROBERTS.(C) AMOUNT OF TRANSACTION: $287,113(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT(E) SHARING OF ORGANIZATION REVENUES? = NO
SCHEDULE L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:	(A) NAME OF INTERESTED PERSON: CHRISTOPHER ROBERTS(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION: FAMILY MEMBER OF OFFICER, CHARLES M. ROBERTS.(C) AMOUNT OF TRANSACTION: $23,190(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT(E) SHARING OF ORGANIZATION REVENUES? = NO
SCHEDULE L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:	(A) NAME OF INTERESTED PERSON: LYNN RODRIGUEZ(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION: FAMILY MEMBER OF OFFICER, CARLOS RODRIGUEZ-GALINDO.(C) AMOUNT OF TRANSACTION: $173,313(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT(E) SHARING OF ORGANIZATION REVENUES? = NO
SCHEDULE L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:	(A) NAME OF INTERESTED PERSON: MONDIRA KUNDU(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION: FAMILY MEMBER OF OFFICER, JOSEPH P. TAYLOR(C) AMOUNT OF TRANSACTION: $108,977(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT(E) SHARING OF ORGANIZATION REVENUES? = NO

Schedule L (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE O
(Form 990)

Department of the Treasury
Internal Revenue Service

Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet

Attach to Form 990 or 990-EZ.
MediumBullet

Go to www.irs.gov/Form990 for the latest information.

OMB No. 1545-0047

2021

Open to Public
Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Return Reference	Explanation
FORM 990, PART VI, SECTION A, LINE 2	FAMILY RELATIONSHIP AMONG DIRECTORS: JOSEPH S. AYOUB, JR., ESQ. AND PAUL J. AYOUB, ESQ.; ROBERT A. BREIT, MD, AND JOSEPH G. SHAKER; JOSEPH C. SHAKER AND JOSEPH G. SHAKER. BUSINESS RELATIONSHIP AMONG DIRECTORS: JOSEPH C. SHAKER AND JOSEPH G. SHAKER; ANN M. DANNER AND CHRISTINA M. RASHID.
FORM 990, PART VI, SECTION B, LINE 11B	IN THE THIRD QUARTER OF THE FISCAL YEAR, THE AUDIT & COMPLIANCE COMMITTEE ARE PROVIDED WITH A DRAFT COPY OF THE FORM 990 AND ALL REQUIRED SCHEDULES. THE AUDIT & COMPLIANCE COMMITTEE MEETS WITH ITS TAX PREPARER TO REVIEW THE DRAFT FORM 990 BEFORE IT IS FILED WITH THE IRS. ADDITIONALLY THE COMPENSATION COMMITTEE OF THE BOARD IS PROVIDED WITH A DRAFT COPY OF THE COMPENSATION SECTIONS OF THE FORM 990, AND THE CONFLICT OF INTEREST COMMITTEE OF THE BOARD IS PROVIDED WITH A DRAFT COPY OF THE CONFLICT-OF-INTEREST SECTIONS OF THE FORM 990 FOR REVIEW BEFORE THE FINALIZED DOCUMENT IS FILED WITH THE IRS. EACH VOTING MEMBER OF THE BOARD IS PROVIDED WITH A FINAL COPY OF THE FORM 990 AND ALL REQUIRED SCHEDULES BEFORE IT IS FILED WITH THE IRS.
FORM 990, PART VI, SECTION B, LINE 12C	NEW BOARD MEMBERS ARE GIVEN A COPY OF THE BOARD OF GOVERNOR'S CONFLICT OF INTEREST POLICY AND COMPLETE A CONFLICT OF INTEREST DISCLOSURE FORM. IN ADDITION, ALL BOARD MEMBERS COMPLETE A CONFLICT OF INTEREST DISCLOSURE UPDATE AT LEAST ANNUALLY. THERE IS A CONFLICT OF INTEREST COMMITTEE OF THE BOARD THAT REVIEWS THE ANNUAL CONFLICT OF INTEREST DISCLOSURE STATEMENTS THAT ARE COMPLETED BY EACH BOARD MEMBER AND DISCUSSES AND RESOLVES CONFLICTS OF INTEREST, WITH OPPORTUNITY FOR APPEAL TO THE FULL BOARD. IN ADDITION, THE ORGANIZATION HAS A CHIEF COMPLIANCE OFFICER AND COMPLIANCE DEPARTMENT, WHICH ADMINISTER THE CONFLICT OF INTEREST DISCLOSURE PROCESS FOR ALL EMPLOYEES IN CLINICAL, RESEARCH, AND SELECT ADMINISTRATIVE DEPARTMENTS, AS WELL AS EMPLOYEES IDENTIFIED AS SUPERVISORS OR WHO HAVE PURCHASING AUTHORITY. ALL SUCH EMPLOYEES COMPLETE CONFLICT OF INTEREST TRAINING AND A CONFLICT OF INTEREST DISCLOSURE ANNUALLY. THE COMPLIANCE OFFICER ENSURES EMPLOYEES MEET THESE REQUIREMENTS AND REVIEWS SUBMITTED DISCLOSURES. DISCLOSURES IDENTIFIED AS AN ACTUAL OR POTENTIAL CONFLICT OF INTEREST ARE ADDRESSED BY THE COMPLIANCE OFFICE WITH INVOLVEMENT OF THE INSTITUTIONAL CONFLICT OF INTEREST COMMITTEE AS APPROPRIATE. DEPENDING ON THE FACTS AND CIRCUMSTANCES, THE ACTIVITY MAY BE MANAGED PURSUANT TO A MANAGEMENT PLAN, OR PROHIBITED.
FORM 990, PART VI, SECTION B, LINE 15	AN INDEPENDENT COMPENSATION COMMITTEE OF THE BOARD, ADVISED BY AN INDEPENDENT OUTSIDE EXPERT, ANNUALLY REVIEWS THE REASONABLENESS OF THE TOTAL REMUNERATION PAID TO DISQUALIFIED PERSONS, INCLUDING THE CEO, OTHER OFFICERS, AND CERTAIN OTHER EMPLOYEES. THE LAST REVIEW WAS COMPLETED IN DECEMBER 2022. THE BOARD'S EXECUTIVE TOTAL REMUNERATION PHILOSOPHY IS INTENDED TO SUPPORT THE ORGANIZATION'S OVERALL STRATEGY AND OBJECTIVES, ATTRACT AND RETAIN EMPLOYEES, LINK COMPENSATION TO PERFORMANCE AND THE ATTAINMENT OF THE ORGANIZATION'S OBJECTIVES, AND PROVIDE REASONABLE COMPENSATION WHILE FULFILLING THE CHARITABLE MISSION OF THE ORGANIZATION. THE BOARD TARGETS TOTAL REMUNERATION BETWEEN THE 50TH AND 75TH PERCENTILES OF THE DEFINED COMPARATOR MARKET, WHILE GIVING DUE CONSIDERATION TO THE MISSION AND THE CHARITABLE NATURE OF THE ORGANIZATION AND THE NEED TO RECRUIT AND RETAIN HIGHLY SKILLED INDIVIDUALS.
FORM 990, PART VI, SECTION C, LINE 19	FINANCIAL STATEMENTS ARE AVAILABLE FROM THE HOSPITAL'S WEBSITE. GOVERNING DOCUMENTS AND THE CONFLICT OF INTEREST POLICY ARE MADE AVAILABLE ONLY AS REQUIRED BY APPLICABLE STATE LAW.
FORM 990, PART XI, LINE 9:	CHANGE IN INTEREST IN NET ASSETS OF ALSAC WITHOUT DONOR RESTRICTIONS 311,260,428. CHANGE IN INTEREST IN NET ASSETS OF ALSAC WITH DONOR RESTRICTIONS -116,073,943.

For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.

Cat. No. 51056K

Schedule O (Form 990) 2021

Additional Data

Software ID:
Software Version:

- TIN:

SCHEDULE R
(Form 990)

Department of the Treasury
Internal Revenue Service

Related Organizations and Unrelated Partnerships

Complete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBullet

Attach to Form 990.
MediumBullet

Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047

2021

Open to Public Inspection

Name of the organization

ST JUDE CHILDREN'S RESEARCH HOSPITAL
INC

Employer identification number

62-0646012

Part I

Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.

(a) Name, address, and EIN (if applicable) of disregarded entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Total income	(e) End-of-year assets	(f) Direct controlling entity
(1) CHILDREN'S GMP LLC 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 47-4475625	VACCINE MANUFACTURER	TN	257,748	2,752,627	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC
(2) THANKS & GIVING LLC 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 20-1310435	ROYALTY INCOME FROM RECORD SALES	TN	0	10,632	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC
(3) THE RIGHT WORDS LLC 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 95-4878579	ROYALTY INCOME FROM BOOK SALES	NY	0	0	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC
(4) ST JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 81-3240987	HIGHER EDUCATION	TN	338,505	1,406,029	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC
(5) ST JUDE CHILDREN'S RESEARCH HOSPITAL HOME CARE LLC 262 DANNY THOMAS PLACE MEMPHIS,TN381053678 85-2379541	HOME HEALTH SERVICE PROVIDER	TN	0	309,807	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC

Part II

Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	(g) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Exempt Code section	(e) Public charity status (if section 501(c)(3))	(f) Direct controlling entity	Yes	No
(1)AMERICAN LEBANESE SYRIAN ASSOCIATED CHARITIES INC 501 ST JUDE PLACE MEMPHIS,TN381053678 35-1044585	SOLICIT SUPPORT FOR OPERATION OF ST. JUDE	IL	501(C)(3)	7	N/A		No

For Paperwork Reduction Act Notice, see the Instructions for Form 990.

Cat. No. 50135Y

Schedule R (Form 990) 2021

Page 2

Part III

Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related organizations treated as a partnership during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?		(k) Percentage ownership
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No	(k) Percentage ownership

Part IV

Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.

(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets	(h) Percentage ownership	(i) Section 512(b)(13) controlled entity?
(a) Name, address, and EIN of related organization	(b) Primary activity	(c) Legal domicile (state or foreign country)	(d) Direct controlling entity	(e) Type of entity (C corp, S corp, or trust)	(f) Share of total income	(g) Share of end-of-year assets	(h) Percentage ownership	Yes	No

Schedule R (Form 990) 2021

Page 3

Part V

Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.

Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.

Yes

1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?

a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................

b Gift, grant, or capital contribution to related organization(s) ............................

c Gift, grant, or capital contribution from related organization(s) ............................

Yes

d Loans or loan guarantees to or for related organization(s) ............................

e Loans or loan guarantees by related organization(s) ............................

f Dividends from related organization(s) ............................

g Sale of assets to related organization(s) ............................

h Purchase of assets from related organization(s) ............................

i Exchange of assets with related organization(s) ............................

j Lease of facilities, equipment, or other assets to related organization(s) .......................

k Lease of facilities, equipment, or other assets from related organization(s) ......................

Yes

l Performance of services or membership or fundraising solicitations for related organization(s) .....................

m Performance of services or membership or fundraising solicitations by related organization(s) .................

Yes

n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................

Yes

o Sharing of paid employees with related organization(s) ............................

Yes

p Reimbursement paid to related organization(s) for expenses ............................

Yes

q Reimbursement paid by related organization(s) for expenses ............................

Yes

r Other transfer of cash or property to related organization(s) ............................

s Other transfer of cash or property from related organization(s) ............................

If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.

(a) Name of related organization	(b) Transaction type (a-s)	(c) Amount involved	(d) Method of determining amount involved

Schedule R (Form 990) 2021

Page 4

Part VI

Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.

Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.

(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	(e) Are all partners section 501(c)(3) organizations?		(f) Share of total income	(g) Share of end-of-year assets	(h) Disproprtionate allocations?		(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	(j) General or managing partner?		(k) Percentage ownership
(a) Name, address, and EIN of entity	(b) Primary activity	(c) Legal domicile (state or foreign country)	Yes	No	(f) Share of total income	(g) Share of end-of-year assets	Yes	No	(i) Code V-UBI amount in box 20 of Schedule K-1 (Form 1065)	Yes	No	(k) Percentage ownership

Schedule R (Form 990) 2021

Page 5

Part VII

Supplemental Information

Provide additional information for responses to questions on Schedule R. See instructions.

Return Reference	Explanation

Schedule R (Form 990) 2021

Additional Data

Software ID:
Software Version:

1	Briefly describe the organization’s mission or most significant activities: THE MISSION OF ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS TO ADVANCE CURES, AND MEANS OF PREVENTION, FOR PEDIATRIC CATASTROPHIC DISEASES THROUGH RESEARCH AND TREATMENT. CONSISTENT WITH THE VISION OF OUR FOUNDER DANNY THOMAS, NO CHILD IS DENIED TREATMENT BASED ON RACE, RELIGION OR A FAMILY'S ABILITY TO PAY.
2	Check this box
3	Number of voting members of the governing body (Part VI, line 1a) ........	3	36
4	Number of independent voting members of the governing body (Part VI, line 1b) .....	4	34
5	Total number of individuals employed in calendar year 2021 (Part V, line 2a) ......	5	6,249
6	Total number of volunteers (estimate if necessary) .............	6	344
7a	Total unrelated business revenue from Part VIII, column (C), line 12 ........	7a	0
b	Net unrelated business taxable income from Form 990-T, Part I, line 11 .........	7b	0

		Prior Year	Current Year
8	Contributions and grants (Part VIII, line 1h) .........	1,130,870,648	1,236,970,064
9	Program service revenue (Part VIII, line 2g) .........	127,720,587	118,235,759
10	Investment income (Part VIII, column (A), lines 3, 4, and 7d ) ....	-493,754	-384,598
11	Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e)	14,099,558	30,863,151
12	Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12)	1,272,197,039	1,385,684,376
13	Grants and similar amounts paid (Part IX, column (A), lines 1–3 )...	1,618,459	1,226,154
14	Benefits paid to or for members (Part IX, column (A), line 4).....	0	0
15	Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10)	628,009,566	675,056,872
16a	Professional fundraising fees (Part IX, column (A), line 11e) .....	0	0
b	Total fundraising expenses (Part IX, column (D), line 25) 0
17	Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e)....	536,928,123	602,286,752
18	Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25)	1,166,556,148	1,278,569,778
19	Revenue less expenses. Subtract line 18 from line 12.......	105,640,891	107,114,598
		Beginning of Current Year	End of Year
20	Total assets (Part X, line 16).............	9,161,722,368	9,470,257,087
21	Total liabilities (Part X, line 26).............	188,169,580	194,588,453
22	Net assets or fund balances. Subtract line 21 from line 20.....	8,973,552,788	9,275,668,634

Sign Here

	Signature of officer	Date

	Type or print name and title


4a	(Code: ) (Expenses $ 585,568,660 including grants of $ 145,946 ) (Revenue $ )
	RESEARCH: THE CURRENT BASIC SCIENCE AND CLINICAL RESEARCH AT THE HOSPITAL INCLUDES WORK IN GENE THERAPY, CHEMOTHERAPY, THE BIOCHEMISTRY OF NORMAL AND CANCEROUS CELLS, RADIATION TREATMENT, BLOOD DISEASES, RESISTANCE TO THERAPY, VIRUSES, NEUROLOGICAL DISEASES, HEREDITARY DISEASES, INFLUENZA, PEDIATRIC AIDS AND PHYSIOLOGICAL EFFECTS OF CATASTROPHIC ILLNESSES.

4b	(Code: ) (Expenses $ 551,616,643 including grants of $ 16,098 ) (Revenue $ 123,359,776 )
	PATIENT CARE: THE HOSPITAL PROVIDED 17,175 INPATIENT DAYS OF CARE DURING THE YEAR. OUR BONE MARROW TRANSPLANTATION PROGRAM ACCOUNTED FOR 4,028 OR 23% OF THOSE INPATIENT DAYS. PATIENTS MADE 70,337 CLINIC REGISTRATIONS DURING THE YEAR.

4c	(Code: ) (Expenses $ 49,067,556 including grants of $ 1,064,110 ) (Revenue $ )
	EDUCATION AND TRAINING: AS PART OF ITS MISSION, THE HOSPITAL HAS DEVELOPED A GLOBAL INITIATIVE (ST. JUDE GLOBAL) TO IMPROVE THE SURVIVAL RATES OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES WORLDWIDE. ST. JUDE GLOBAL ACCOMPLISHES THIS BY SHARING KNOWLEDGE, TECHNOLOGY AND ORGANIZATIONAL SKILLS, HELPING TO IMPLEMENT NEW APPROACHES TO TREAT PEDIATRIC CANCER GLOBALLY, AND DEVELOPING REGIONAL NETWORKS COMMITTED TO ERADICATING CANCER IN CHILDREN. THIS MISSION WILL BE ACHIEVED BY FOCUSING ON THREE OVERRIDING GOALS: (1) TO TRAIN THE CLINICAL WORKFORCE THAT WILL BE REQUIRED TO MEET OUR MISSION, (2) TO DEVELOP AND STRENGTHEN HEALTH SYSTEMS AND PATIENT-CENTERED INITIATIVES THAT ENCOMPASS THE ENTIRE CONTINUUM OF CARE REQUIRED FOR CHILDREN WITH CANCER AND NON-MALIGNANT HEMATOLOGICAL (CONTINUED ON SCHEDULE O) DISEASES, AND (3) TO ADVANCE KNOWLEDGE IN GLOBAL PEDIATRIC ONCOLOGY AND HEMATOLOGY THROUGH RESEARCH TO SUSTAIN A CONTINUOUS IMPROVEMENT IN THE LEVEL AND QUALITY OF CARE DELIVERED AROUND THE GLOBE. THESE INITIATIVES ARE SPEARHEADED BY ST. JUDE EXPERTS WHO WORK CLOSELY WITH HEALTHCARE PROFESSIONALS AT OUR PARTNER SITES. IN ADDITION, A GRADUATE PROGRAM AT THE DOCTORAL AND MASTER'S LEVEL IS OFFERED THROUGH A WHOLLY-OWNED SUBSIDIARY, ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC, TO EDUCATE AND TRAIN FUTURE GENERATIONS OF SCIENTISTS SEEKING TO UNDERSTAND THE MOLECULAR BASIS OF HUMAN DISEASE AND DEVELOP NOVEL THERAPIES BASED ON THAT UNDERSTANDING.

4d	Other program services (Describe in Schedule O.)
	(Expenses $ including grants of $ ) (Revenue $ )
4e	Total program service expenses1,186,252,859

1b	Sub-Total................
c	Total from continuation sheets to Part VII, Section A....
d	Total (add lines 1b and 1c)...........	11,549,974	957,998	1,639,240

1a	Federated campaigns..		1a
b	Membership dues..		1b
c	Fundraising events..		1c
d	Related organizations		1d	1,083,764,954
e	Government grants (contributions)		1e	129,245,382

f	All other contributions, gifts, grants, and similar amounts not included above		1f	23,959,728

g	Noncash contributions included in lines 1a - 1f:$		1g

h Total. Add lines 1a-1f.......		1,236,970,064

		Business Code
2a	PATIENT CARE	621110	118,235,759	118,235,759
b
c
d
e
f	All other program service revenue.
g	Total. Add lines 2a–2f .....		118,235,759

3 Investment income (including dividends, interest, and othersimilar amounts) ......			20,473			20,473
4 Income from investment of tax-exempt bond proceeds
5 Royalties...........			22,069,533			22,069,533
		(ii) Personal	(i) Real
6a	Gross rents			6a
b	Less: rental expenses			6b
c	Rental income or (loss)			6c
d	Net rental income or (loss).......
		(ii) Other	(i) Securities
7a	Gross amount from sales of assets other than inventory	15,498	1,550,265	7a
b	Less: cost or other basis and sales expenses	611,429	1,359,405	7b
c	Gain or (loss)	-595,931	190,860	7c
d	Net gain or (loss).........			-405,071	-595,931		190,860
8a	Gross income from fundraising events (not including $ of contributions reported on line 1c). See Part IV, line 18 ....
			8a
b	Less: direct expenses ...		8b
c	Net income or (loss) from fundraising events..
9a	Gross income from gaming activities. See Part IV, line 19 ...
			9a
b	Less: direct expenses ...		9b
c	Net income or (loss) from gaming activities..
10a	Gross sales of inventory, less returns and allowances ..
			10a
b	Less: cost of goods sold ..		10b
c	Net income or (loss) from sales of inventory..
Business Code			Miscellaneous Revenue
11a	CAFETERIA/VENDING		722514	3,073,670			3,073,670
b	CHGME/CHCA		900099	2,811,538	2,811,538
c	HHMI		900099	173,725	173,725
d	All other revenue ....			2,734,685	2,734,685
e	Total. Add lines 11a–11d ......			8,793,618
12	Total revenue. See instructions.....			1,385,684,376	123,359,776	0	25,354,536

1	Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 ....	155,256	155,256
2	Grants and other assistance to domestic individuals. See Part IV, line 22 ...........
3	Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. .............	1,070,898	1,070,898
4	Benefits paid to or for members .......
5	Compensation of current officers, directors, trustees, and key employees ...........	7,284,680	5,124,005	2,160,675
6	Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........
7	Other salaries and wages........	512,583,722	477,653,674	34,930,048
8	Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) ....	32,325,563	30,122,736	2,202,827
9	Other employee benefits .......	86,096,544	80,229,490	5,867,054
10	Payroll taxes ...........	36,766,363	34,260,917	2,505,446
11	Fees for services (non-employees):
a	Management ......	40,870,029	37,756,988	3,113,041
b	Legal .........	2,403,402	2,220,337	183,065
c	Accounting ...........	307,963	284,506	23,457
d	Lobbying ...........	91,375		91,375
e	Professional fundraising services. See Part IV, line 17
f	Investment management fees ......
g	Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O)	115,563,134	95,710,586	19,852,548
12	Advertising and promotion ....	1,319,195	1,218,713	100,482
13	Office expenses .......	4,735,756	4,410,141	325,615
14	Information technology ......	90,122,791	83,258,203	6,864,588
15	Royalties ..
16	Occupancy ...........	46,913,123	37,262,303	9,650,820
17	Travel ............	9,755,299	9,494,682	260,617
18	Payments of travel or entertainment expenses for any federal, state, or local public officials .
19	Conferences, conventions, and meetings ....	1,860,601	1,103,548	757,053
20	Interest ...........
21	Payments to affiliates .......
22	Depreciation, depletion, and amortization ..	106,213,140	91,835,853	14,377,287
23	Insurance ...	3,121,691	1,786,711	1,334,980
24	Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a	LABORATORY SUPPLIES	62,796,986	61,455,139	1,341,847
b	PHARMACUETICAL SUPPLIES	59,727,922	58,451,655	1,276,267
c	TELEPHONE	2,134,974	1,870,920	264,054
d	ALLOCATION ADJUSTMENTS	0	23,448,893	-23,448,893
e	All other expenses	54,349,371	46,066,705	8,282,666
25	Total functional expenses. Add lines 1 through 24e	1,278,569,778	1,186,252,859	92,316,919	0
26	Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here if following SOP 98-2 (ASC 958-720).

1	Cash–non-interest-bearing ........			3,864,893	1	18,590,321
2	Savings and temporary cash investments .........				2
3	Pledges and grants receivable, net ......			39,278,772	3	46,885,661
4	Accounts receivable, net .............			21,105,668	4	22,281,798
5	Loans and other receivables from any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
					5
6	Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
					6
7	Notes and loans receivable, net ...........				7
8	Inventories for sale or use ............			17,701,525	8	18,797,418
9	Prepaid expenses and deferred charges ......			27,450,531	9	25,766,884
10a	Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D	10a	2,245,812,620
b	Less: accumulated depreciation	10b	1,176,698,010	1,004,096,670	10c	1,069,114,610
11	Investments—publicly traded securities .			3,209,430	11	3,235,526
12	Investments—other securities. See Part IV, line 11 .....				12
13	Investments—program-related. See Part IV, line 11 ..				13
14	Intangible assets ...............				14
15	Other assets. See Part IV, line 11 ...........			8,045,014,879	15	8,265,584,869
16	Total assets. Add lines 1 through 15 (must equal line 33)...			9,161,722,368	16	9,470,257,087

17	Accounts payable and accrued expenses .....	160,901,221	17	172,965,910
18	Grants payable ...		18
19	Deferred revenue .........	17,262,757	19	11,486,363
20	Tax-exempt bond liabilities .........		20
21	Escrow or custodial account liability. Complete Part IV of Schedule D		21
22	Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
			22
23	Secured mortgages and notes payable to unrelated third parties ..		23
24	Unsecured notes and loans payable to unrelated third parties ..		24
25	Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D	10,005,602	25	10,136,180
26	Total liabilities. Add lines 17 through 25..	188,169,580	26	194,588,453

	Organizations that follow FASB ASC 958, check here and complete lines 27, 28, 32, and 33.
27	Net assets without donor restrictions ..........	7,617,971,425	27	8,036,161,214
28	Net assets with donor restrictions ...........	1,355,581,363	28	1,239,507,420
	Organizations that do not follow FASB ASC 958, check here and complete lines 29 through 33.
29	Capital stock or trust principal, or current funds .....		29
30	Paid-in or capital surplus, or land, building or equipment fund ...		30
31	Retained earnings, endowment, accumulated income, or other funds		31
32	Total net assets or fund balances ...........	8,973,552,788	32	9,275,668,634
33	Total liabilities and net assets/fund balances ........	9,161,722,368	33	9,470,257,087

1	Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
2	Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
3	Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
4	Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .	Yes	No
5	Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No
6	Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .	Yes	No