Form990


Department of the TreasuryInternal Revenue Service
Return of Organization Exempt From Income Tax
Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)
MediumBullet Do not enter social security numbers on this form as it may be made public.
MediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public Inspection
A For the 2021 calendar year, or tax year beginning 07-01-2022 , and ending 06-30-2023
BCheck if applicable:
CName of organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
 
Doing business as
 
 
Number and street (or P.O. box if mail is not delivered to street address)
1201 NINTH AVENUE
 
Room/suite
City or town, state or province, country, and ZIP or foreign postal code
SEATTLE, WA98101
D Employer identification number

91-0653422
E Telephone number

G Gross receipts $ 82,477,055
F Name and address of principal officer:
JANE BUCKNER MD
1201 NINTH AVENUE
SEATTLE,WA981012795
I
Tax-exempt status: (   ) LeftBullet (insert no.) or
J
Website:MediumBullet
HTTP://WWW.BENAROYARESEARCH.ORG
H(a)
Is this a group return for
subordinates?
H(b)
Are all subordinates
included?
If "No," attach a list. See instructions.
H(c)
Group exemption number MediumBullet  
K Form of organization:  
L Year of formation: 1956
M State of legal domicile: WA
Part I
Summary
Activities & Governance 1 Briefly describe the organization’s mission or most significant activities: TO ADVANCE THE SCIENCE THAT WILL PREDICT, PREVENT, REVERSE, AND CURE DISEASES OF THE IMMUNE SYSTEM.
2 Check this box MediumBullet
3 Number of voting members of the governing body (Part VI, line 1a) ........ 3 13
4 Number of independent voting members of the governing body (Part VI, line 1b) ..... 4 13
5 Total number of individuals employed in calendar year 2021 (Part V, line 2a) ...... 5 353
6 Total number of volunteers (estimate if necessary) ............. 6 0
7a Total unrelated business revenue from Part VIII, column (C), line 12 ........ 7a 0
b Net unrelated business taxable income from Form 990-T, Part I, line 11 ......... 7b 0
Revenues Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ......... 78,966,995 75,771,314
9 Program service revenue (Part VIII, line 2g) ......... 5,286,187 5,702,614
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d ) .... 9,899,625 282,812
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) 708,469 708,503
12 Total revenue—add lines 8 through 11 (must equal Part VIII, column (A), line 12) 94,861,276 82,465,243
Expenses; 13 Grants and similar amounts paid (Part IX, column (A), lines 1–3 )... 33,518,144 31,762,808
14 Benefits paid to or for members (Part IX, column (A), line 4)..... 0 0
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5–10) 33,277,902 34,326,207
16a Professional fundraising fees (Part IX, column (A), line 11e) ..... 0 0
b Total fundraising expenses (Part IX, column (D), line 25) MediumBullet0    
17 Other expenses (Part IX, column (A), lines 11a–11d, 11f–24e).... 16,989,508 17,237,972
18 Total expenses. Add lines 13–17 (must equal Part IX, column (A), line 25) 83,785,554 83,326,987
19 Revenue less expenses. Subtract line 18 from line 12....... 11,075,722 -861,744
Net Assets or Fund Balances; Beginning of Current Year End of Year
20 Total assets (Part X, line 16)............. 100,143,058 94,354,363
21 Total liabilities (Part X, line 26)............. 45,307,373 42,735,678
22 Net assets or fund balances. Subtract line 21 from line 20..... 54,835,685 51,618,685
Part II
Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
Sign Here
JumboBullet
Signature of officer Date
JumboBullet
Type or print name and title
Paid Preparer Use Only
Print/Type preparer's name
Preparer's signature
Date
PTIN
Firm's name MediumBullet

Firm's EIN MediumBullet
Firm's address MediumBullet



Phone no.
May the IRS discuss this return with the preparer shown above? (see instructions) ..........
For Paperwork Reduction Act Notice, see the separate instructions.
Cat. No. 11282Y Form 990 (2021)
Form 990 (2021)
Page 2
Part III
Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III..............
1
Briefly describe the organization’s mission: TO ADVANCE THE SCIENCE THAT WILL PREDICT, PREVENT, REVERSE, AND CURE DISEASES OF THE IMMUNE SYSTEM SUCH AS AUTOIMMUNE DISEASE, ALLERGY, AND ASTHMA.
2
Did the organization undertake any significant program services during the year which were not listed on
the prior Form 990 or 990-EZ? .....................
If "Yes," describe these new services on Schedule O.
3
Did the organization cease conducting, or make significant changes in how it conducts, any program
services? ...........................
If "Yes," describe these changes on Schedule O.
4
Describe the organization’s program service accomplishments for each of its three largest program services, as measured by expenses. Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and revenue, if any, for each program service reported.
4a (Code:   ) (Expenses $ 39,677,626 including grants of $ 24,639,484 ) (Revenue $ 0 )
INTERVENTIONAL IMMUNOLOGYINTERVENTIONAL IMMUNOLOGY AND ADVANCEMENTS OF THE IMMUNE TOLERANCE NETWORK (ITN) ARE HIGHLIGHTED BELOW. FUNDING FOR THE IMMUNE TOLERANCE NETWORK (ITN) WAS INITIALLY AWARDED TO DR. JERRY NEPOM AT BRI IN 2014 BY THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASE (NIAID) OF THE NATIONAL INSTITUTES OF HEALTH (NIH). IT WAS LATER RENEWED FOR A SECOND GRANT CYCLE IN 2021, PROVIDING APPROXIMATELY $27 MILLION ANNUALLY TO SUPPORT THE ITN. THIS RESEARCH CONSORTIUM, ESTABLISHED IN 1999, PRIMARILY FOCUSES ON DEVELOPING NEW TOLEROGENIC APPROACHES FOR TREATING AND PREVENTING DISEASES IN THREE CLINICAL AREAS: ASTHMA AND ALLERGIC DISEASES, AUTOIMMUNE DISEASES, AND IMMUNE-MEDIATED REJECTION OF TRANSPLANTED SOLID ORGANS, TISSUES, AND CELLS. BRI, AS THE PRIME RECIPIENT OF THIS GRANT, IS RESPONSIBLE FOR MANAGING THE OVERALL GRANT FROM NIAID, INCLUDING OVERSEEING ALL ASPECTS OF THE NETWORK'S INFRASTRUCTURE.DURING THIS PERIOD, MAJOR ACTIVITIES REMAINED DIVERSE BUT CONTINUED TO CENTER AROUND MAINTAINING THE ITN'S COHESIVE, PROJECT-FOCUSED ENVIRONMENT, WHICH HAS BEEN HIGHLY SUCCESSFUL IN MANAGING THIS LARGE COOPERATIVE AGREEMENT GRANT.KEY OUTCOMES DURING THIS PERIOD INCLUDE:1. LEADERSHIP CHANGES: WITH THE CHANGES TO THE OVERALL ITN LEADERSHIP STRUCTURE OUTLINED IN THE 2021 GRANT APPLICATION FULLY IMPLEMENTED. DR. JERRY NEPOM STEPPED DOWN AS THE NETWORK DIRECTOR AND PRINCIPAL INVESTIGATOR, AND ALTHOUGH NOW RETIRED, REMAINS INVOLVED WITH THE ITN IN A SENIOR ADVISOR ROLE. THE PRIMARY INVESTIGATOR FOR THE UM1 GRANT IS NOW DR. JANE BUCKNER, PRESIDENT OF BRI. SHE ALSO SERVES ON THE ITN STEERING COMMITTEE AND THE ITN NETWORK EXECUTIVE COMMITTEE, PLAYING AN ACTIVE ROLE IN TRACKING PROGRESS TOWARDS NETWORK GOALS AND DEVELOPING STRATEGIES TO MEET NETWORK OBJECTIVES. THE FUNCTION OF THE NETWORK DIRECTOR'S OFFICE AT BRI CONTINUES WITH NO CHANGES, EXCEPT FOR A NAME CHANGE TO THE ITN COORDINATING CENTER. THE NETWORK DIRECTOR POSITION MOVED TO DR. MARK ANDERSON AT UCSF, FUNDED THROUGH A SUBAWARD FROM THE BRI ITN COORDINATING CENTER. 2. THE ITN CROSS-NETWORK INTEGRATION: SINCE 2014, DR. NEPOM HAS LED THE ITN WITH A STRONG FOCUS ON METICULOUS PLANNING AND COLLABORATION ACROSS THE ITN'S MAJOR CENTERS, LOCATED IN SEATTLE (BRI), SAN FRANCISCO (UCSF), DURHAM, NC (DUKE), BOSTON (BWH), ATLANTA (EMORY), AND ANN ARBOR (U OF MICHIGAN). EFFECTIVE COLLABORATION WAS PARTICULARLY EVIDENT WHEN, DESPITE THE GLOBAL PANDEMIC, THE ITN CONDUCTED ITS NETWORK STEERING COMMITTEE (NSC) REMOTELY, APPROVING FIVE NEW CLINICAL TRIALS DURING THE REPORTING PERIOD. IN 2022/2023, THE ITN RETURNED TO CONDUCTING IN-PERSON NSC MEETINGS, WHICH CONTINUED WITHOUT INTERRUPTION. WITH STRONG APPROVAL FROM NIAID FOR THE ITN'S OVERALL INFRASTRUCTURE AND THE DESIRE TO KEEP THE COORDINATING CENTER OPERATIONS AT BRI WITH DR. BUCKNER, THERE ARE NO PLANNED CHANGES THROUGHOUT THE CURRENT GRANT CYCLE, WHICH EXTENDS UNTIL 2027.3. OPERATIONS AND CLINICAL TRIAL SUPPORT: THE ITN COORDINATING CENTER AT BRI ISSUED OVER 250 SUBAWARDS DURING THIS REPORTING PERIOD TO SUPPORT 24 ACTIVE ITN CLINICAL TRIALS AND NUMEROUS SUPPORTING ITN MECHANISTIC TRIALS. AN ADDITIONAL 22 SUBAWARDS WERE NEGOTIATED IN SUPPORT OF THE TWO REMAINING NIAID COVID TRIALS.4. SUPPLEMENTAL FUNDING / PARTNERSHIPS: THE ITN COORDINATING CENTER CONTINUED TO FOCUS ON IDENTIFYING ADDITIONAL OPPORTUNITIES FOR SUPPLEMENTAL FUNDING AND FUNDING PARTNERSHIPS. NEGOTIATIONS FOR A PARTNERSHIP TO PROVIDE PARTIAL FINANCIAL SUPPORT FOR AT LEAST ONE CLINICAL TRIAL IN DEVELOPMENT ARE ACTIVELY UNDERWAY.DURING THIS REPORTING PERIOD, THE ITN ALSO SUPPORTED THE CONTRACTING COMPONENT FOR TWO NIAID-SPONSORED COVID-19 CLINICAL TRIALS FUNDED THROUGH ADMINISTRATIVE SUPPLEMENTS. BOTH TRIALS ARE ON TRACK TO CONCLUDE BY Q4 2024:(A) SUPPLEMENTAL FUNDING OPPORTUNITIES: THE ITN COORDINATING CENTER AT BRI SUBMITTED TWO SUPPLEMENTAL FUNDING REQUESTS IN 2022, WHICH WERE CARRIED OVER INTO 2023. THESE SUPPLEMENTS ACCOUNT FOR AN ADDITIONAL $7 MILLION ALLOCATED TO THE ITN PROGRAM AT BRI DURING THIS TIME PERIOD.(B) PARTNERSHIPS: THE ITN CONTINUED ITS PARTNERSHIP WITH PHARMACEUTICAL COMPANY FOR PARTIAL FUNDING FOR AN ITN STUDY. NIAID IS THE CLINICAL SPONSOR OF THIS TRIAL, WHICH IS PROGRESSING AS PLANNED FOR COMPLETION IN Q2 2024.5. PUBLICATION ACTIVITY: IN TOTAL, 44 ITN PUBLICATIONS WERE PUBLISHED DURING THIS REPORTING PERIOD IN PRESTIGIOUS RESEARCH JOURNALS AND WERE PRESENTED AT DOMESTIC AND INTERNATIONAL RESEARCH CONFERENCES. THESE PUBLICATIONS REPRESENTED ITN RESEARCH IN ALL THERAPEUTIC FOCUS AREAS: AUTOIMMUNITY, TRANSPLANTATION, AND ALLERGY.
4b (Code:   ) (Expenses $ 21,063,694 including grants of $ 6,517,681 ) (Revenue $ 0 )
TYPE ONE DIABETES RESEARCHBRI IS DEDICATED TO SEEKING WAYS TO ELIMINATE TYPE 1 DIABETES (T1D) BY FINDING WAYS TO PREDICT THE DISEASE BEFORE CLINICAL SYMPTOMS OCCUR AND TO IDENTIFY THERAPIES THAT PREVENT, REVERSE AND INTERVENE IN THE DISEASE AT ANY STAGE. BRI IS AN INTERNATIONAL LEADER IN TYPE 1 DIABETES RESEARCH AND HAS INVESTIGATED IT FOR MORE THAN 36 YEARS, STARTING WITH IDENTIFICATION OF A GENETIC MARKER FOR THE DISEASE. BRI SUPPORTS TYPE 1 DIABETES TRIALNET, A NATIONAL INSTITUTES OF HEALTH FUNDED CLINICAL TRIAL NETWORK FOR TYPE 1 DIABETES PREVENTION AND EARLY TREATMENT, SERVING AS THE TRIALNET HUB OF 18 CLINICAL CENTERS WORLDWIDE WORKING WITH MORE THAN 150 SCREENING AND CLINICAL RESEARCH SITES. BRI IS ALSO A CLINICAL CENTER FOR THE TRIALNET PATHWAY TO PREVENTION STUDY, SCREENING RELATIVES OF PEOPLE WITH TYPE 1 DIABETES TO FIND OUT IF THESE FAMILY MEMBERS ARE AT RISK FOR DEVELOPING DIABETES. RELATIVES OF PEOPLE WITH TYPE 1 DIABETES ARE AT 15 TIMES GREATER RISK OF DEVELOPING TYPE 1 DIABETES. THOSE WHO QUALIFY HAVE THE OPPORTUNITY TO ENROLL IN A PREVENTION TRIAL. THOSE WITH TWO OR MORE AUTOANTIBODIES ARE CLOSELY MONITORED FOR EARLY DETECTION OF TYPE 1 DIABETES. CLOSE MONITORING OF AT-RISK FAMILY MEMBERS CAN REDUCE THE CHANCES OF BEING DIAGNOSED IN DIABETIC KETOACIDOSIS (DKA), A POTENTIALLY LIFE-THREATENING COMPLICATION. BRI SCIENTISTS LED BY CARLA GREENBAUM, MD, DIRECTOR OF BRI'S CENTER FOR INTERVENTIONAL IMMUNOLOGY, ALONG WITH THE TRIALNET CONSORTIUM SPENT DECADES TRYING TO DETERMINE HOW TO STOP T1D BEFORE IT STARTS. THEIR HARD WORK CAME TO FRUITION IN NOVEMBER 2022, WHEN THE FDA APPROVED A THERAPY THAT MARKED A MILESTONE IN PREVENTING T1D. THE THERAPY, TEPLIZUMAB, CAN DELAY T1D FOR A MEDIAN OF TWO YEARS. IT IMPACTS T CELLS IN THE IMMUNE SYSTEM, DAMPENING THE IMMUNE RESPONSE. IN T1D, THE IMMUNE SYSTEM IS ATTACKING THE INSULIN-PRODUCING BETA CELLS; TEPLIZUMAB HELPS SLOW THE ATTACK ON THESE CELLS.AND, A STUDY LED BY BRI'S CATE SPEAKE, PHD, FOUND THAT INTERVENTIONS INVOLVING IL-6-TARGETED THERAPIES IMPACTED IMMUNE OUTCOMES IN PEOPLE WITH T1D, DEPENDING ON THE TARGET OF THE THERAPEUTIC INTERVENTIONS (IL-6 VERSUS IL-6R) AND DRUG CONCENTRATION. THE FINDINGS INDICATE THAT THESE THERAPIES DRIVE T CELL CHANGES THAT CAN INFLUENCE THERAPEUTIC OUTCOMES.ALSO IN 2022, BRI SCIENTISTS ALONG WITH INVESTIGATORS AT SEATTLE CHILDREN'S RESEARCH INSTITUTE MADE A SIGNIFICANT ADVANCE IN DEVELOPING A T CELL THERAPY TO T1D TREAT TYPE 1 DIABETES (T1D). THE STUDY, PUBLISHED IN OCTOBER 2022 IN SCIENCE TRANSLATIONAL MEDICINE, OUTLINED AN APPROACH TO ENGINEER REGULATORY T CELLS (TREGS) TO STOP THE IMMUNE CELL ATTACK ON THE PANCREAS THAT CAUSES T1D.DR. JANE BUCKNER, PRESIDENT OF BRI, AND DR. DAVID RAWLINGS, DIRECTOR OF THE CENTER FOR IMMUNITY AND IMMUNOTHERAPY AT SEATTLE CHILDREN'S RESEARCH INSTITUTE, AND THEIR TEAMS HAD WORKED TOWARD THIS GOAL FOR MORE THAN TEN YEARS. FIRST, THEY DEVELOPED GENE EDITING METHODS TO MANUFACTURE HUMAN TREGS, AN IMPORTANT STEP FOR OVERCOMING CHALLENGES WITH PURIFYING AND EXPANDING TREGS FROM BLOOD FOR CLINICAL PRODUCTION. THIS WORK DEMONSTRATED THAT ENGINEERED TREGS (ENGTREGS) WERE FUNCTIONAL, SUPPRESSING THE IMMUNE RESPONSE IN PRE-CLINICAL MODELS OF INFLAMMATORY DISEASES.THE NEXT STEP WAS TO MAKE THESE ENGTREGS SPECIFIC TO THE PANCREAS, SO THAT THEY WOULD GO TO THE PANCREAS AND SUPPRESS THE AUTOIMMUNE RESPONSE THAT CAUSES T1D. TO DO THIS, THE SCIENTISTS USED THEIR KNOWLEDGE OF T CELL RECEPTORS (TCRS), PROTEINS ON THE T CELL SURFACE THAT DETERMINE THE TARGET OF T CELLS. THEY COMBINED GENE EDITING WITH GENE TRANSFER OF TCRS TO GENERATE ENGTREGS THAT SPECIFICALLY TARGET THE ISLET IN THE PANCREAS.DR. SOO JUNG YANG IN DR. BUCKNER'S LAB DEMONSTRATED THAT THESE ISLET-SPECIFIC ENGTREGS HAVE THE CAPACITY TO SUPPRESS T CELLS ATTACKING THE PANCREAS USING CELL CULTURE MODELS OF CELLS ISOLATED FROM INDIVIDUALS WITH T1D. DR. RAWLINGS AND HIS TEAM THEN DEMONSTRATED THAT THESE ISLET-SPECIFIC ENGTREGS TARGET THE PANCREAS AND PREVENT DIABETES IN A MOUSE MODEL OF DIABETES. TOGETHER THESE FINDINGS DEMONSTRATE THE THERAPEUTIC POTENTIAL FOR ISLET-SPECIFIC ENGTREGS IN HUMAN T1D. THIS RESEARCH WAS SPONSORED BY A GRANT FROM THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST.VIRAL AND POLLUTANT EXPOSURES AND POTENTIAL TREATMENTS FOR PEOPLE AT RISK FOR ASTHMA MATT ALTMAN, MD, MPHIL, WHO CONDUCTS ASTHMA RESEARCH AT BRI AND TREATS ASTHMA PATIENTS AT UW MEDICINE, WAS SENIOR AUTHOR OF A STUDY THAT IDENTIFIED A POTENTIALLY PROMISING NEW ASTHMA TREATMENT FOR URBAN KIDS AT RISK FOR THE DISEASE. THE STUDY FROM THE INNER-CITY ASTHMA CONSORTIUM (ICAC) FOUND THAT A THERAPY CALLED MEPOLIZUMAB CAN REDUCE ASTHMA ATTACKS AMONG CHILDREN IN LOW-INCOME HISPANIC AND BLACK COMMUNITIES. MEPOLIZUMAB WORKS BY BLOCKING A PROTEIN NECESSARY FOR THE DEVELOPMENT OF EOSINOPHIL, A TYPE OF WHITE BLOOD CELL. IN ANOTHER STUDY, PUBLISHED IN THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, BRI RESEARCHERS IN COLLABORATION WITH SEATTLE CHILDREN'S, THE UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE AND THE UNIVERSITY OF WISCONSIN DISCOVERED WHY INDIVIDUALS WITH ALLERGIC ASTHMA MAY HAVE REDUCED SUSCEPTIBILITY TO COVID-19 AND AN IMPORTANT MECHANISM BY WHICH ALLERGIC INFLAMMATION DIMINISHES SARS-COV-2 INFECTION, DESPITE WELL-KNOWN SUSCEPTIBILITIES TO OTHER RESPIRATORY VIRAL INFECTIONS. ALLERGIC DISEASES SUCH AS ASTHMA ARE CHARACTERIZED BY TYPE-2 INFLAMMATION IN THE AIRWAYS. BRI'S NARESH DONI JAYAVELU, PHD, AND THE RESEARCH TEAM LOOKED AT MECHANISMS WHEREBY TYPE-2 INFLAMMATION IN THE AIRWAY SURPRISINGLY PROTECTS AGAINST SARS-COV-2 IN CHILDREN. THE FINDINGS ALSO ILLUSTRATE A NOTABLE MECHANISM OF INTRINSIC PROTECTION AGAINST SARS-COV-2. SINCE THE STUDY FINDINGS WERE BASED ON IN VITRO CELL CULTURE EXPERIMENTS, DRS. JAYAVELU AND ALTMAN SUBSEQUENTLY BEGAN TO INVESTIGATE TO WHAT DEGREE TYPE-2 INFLAMMATION DECREASES VIRAL REPLICATION AND SEVERE DISEASE IN A LARGE OBSERVATIONAL COHORT THAT WAS ENROLLED AT THE BEGINNING OF THE PANDEMIC TO MORE FULLY UNDERSTAND THE CLINICAL IMPACT OF THEIR RESULTS. THIS RESEARCH WAS FUNDED BY THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, PART OF THE NATIONAL INSTITUTES OF HEALTH, AND OTHER SOURCES, BUILDING ON A PREVIOUS STUDY THAT SET THE GROUNDWORK FOR A HYPOTHETICAL MECHANISM OF PROTECTION. A SEPARATE STUDY FUNDED BY THE NIH LINKED SPECIFIC OUTDOOR AIR POLLUTANTS TO ASTHMA ATTACKS IN URBAN CHILDREN. IN THE STUDY, MODERATE LEVELS OF TWO OUTDOOR AIR POLLUTANTS, OZONE AND FINE PARTICULATE MATTER, WERE ASSOCIATED WITH NON-VIRAL ASTHMA ATTACKS IN CHILDREN AND ADOLESCENTS WHO LIVE IN LOW-INCOME URBAN AREAS. THE STUDY ALSO IDENTIFIED ASSOCIATIONS BETWEEN EXPOSURE TO THE TWO POLLUTANTS AND MOLECULAR CHANGES IN THE CHILDREN'S AIRWAYS DURING NON-VIRAL ASTHMA ATTACKS, SUGGESTING POTENTIAL MECHANISMS FOR THOSE ATTACKS. THIS STUDY WAS CONDUCTED BY THE NIAID-FUNDED INNER CITY ASTHMA CONSORTIUM UNDER THE LEADERSHIP OF DR. ALTMAN ALONG WITH DANIEL J. JACKSON, M.D. OF THE UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE.THE OBSERVATIONAL STUDY IS ONE OF THE FIRST TO LINK ELEVATED LEVELS OF SPECIFIC OUTDOOR AIR POLLUTANTS IN PARTICULAR URBAN LOCATIONS TO DISTINCT CHANGES IN THE AIRWAYS DURING ASTHMA ATTACKS NOT TRIGGERED BY RESPIRATORY VIRUSES, ACCORDING TO THE INVESTIGATORS. THE FINDINGS WERE PUBLISHED IN THE JOURNAL THE LANCET PLANETARY HEALTH.THE SCIENTISTS FOUND THAT ASTHMA ATTACKS HAD A NON-VIRAL CAUSE IN NEARLY 30% OF CHILDREN, TWO TO THREE TIMES THE PROPORTION SEEN IN NON-URBAN CHILDREN, ACCORDING TO PREVIOUSLY PUBLISHED REPORTS. THESE ATTACKS WERE ASSOCIATED WITH LOCALLY ELEVATED LEVELS OF FINE PARTICULATE MATTER AND OZONE IN OUTDOOR AIR. THE INVESTIGATORS LINKED CHANGES IN THE EXPRESSION OF SPECIFIC SETS OF GENES THAT PLAY A ROLE IN AIRWAY INFLAMMATION TO ELEVATED LEVELS OF THESE TWO POLLUTANTS BY ANALYZING NASAL CELL SAMPLES OBTAINED FROM THE CHILDREN DURING RESPIRATORY ILLNESSES.
4c (Code:   ) (Expenses $ 6,363,186 including grants of $ 448,628 ) (Revenue $ 0 )
AUTOIMMUNE DISEASE RESEARCH IN THE DOWN SYNDROME POPULATIONIN OCTOBER 2022, THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) ANNOUNCED A NEW $3.4 MILLION-DOLLAR FIVE-YEAR RESEARCH PROJECT GRANT (R01) TO BRI TO STUDY WHY IMMUNE RESPONSES ARE ALTERED IN THOSE WITH DOWN SYNDROME (DS).BERNARD KHOR, MD, PHD, IN PARTNERSHIP WITH VIRGINIA MASON PEDIATRICIAN AND BRI RESEARCHER REBECCA PARTRIDGE, MD, LEADS THE R01 GRANT THAT BUILDS ON HIS PRIOR FINDINGS THAT ANY GIVEN PERSON WITH DS HAS AN IMMUNE SYSTEM THAT RESEMBLES THAT OF A SIGNIFICANTLY OLDER INDIVIDUAL WITHOUT DS. WITH THIS GRANT, HE WILL EXAMINE THE MECHANISMS BEHIND ADVANCED IMMUNE AGING AND EXPLORE HOW THIS IMPACTS CLINICALLY RELEVANT RESPONSES, SUCH AS THE ABILITY TO MOUNT AN EFFECTIVE RESPONSE TO VACCINATION. HIS WORK IS MADE POSSIBLE BY THE BRI BIOREPOSITORIES OF BLOOD AND TISSUE SAMPLES FROM PEOPLE WITH DS.IN HIS PREVIOUS STUDIES, DR. KHOR AND HIS TEAM USED MASS CYTOMETRY TO EXAMINE THE IMMUNE SYSTEMS OF 28 PEOPLE WITH DS AND, THROUGH THE CREATION OF A NEW ANALYTICAL SOFTWARE, SHOWED HOW THESE IMMUNE SYSTEMS SHARE CHARACTERISTICS WITH THOSE OF MUCH OLDER SUBJECTS WHO DO NOT HAVE DS, AS WELL AS WITH INDIVIDUALS WITH CERTAIN AUTOIMMUNE DISEASES. FOR THE FIRST TIME, A PROTEIN CALLED IL-6 WAS ASSOCIATED WITH CHANGES THAT DRIVE AGING OF THE IMMUNE SYSTEM.THE TEAM BELIEVES THEIR FINDINGS MAY ALSO HELP EXPLAIN WHY PEOPLE WITH DS ARE MORE LIKELY TO DEVELOP AUTOIMMUNE DISEASES SUCH AS TYPE 1 DIABETES, CELIAC DISEASE AND RHEUMATOID ARTHRITIS.
(Code:   ) (Expenses $ 1,948,500 including grants of $ 157,015 ) (Revenue $ 5,702,614 )
EXAMINING THE IMMUNE SYSTEM IN HEALTH AND DISEASE BRI ALONG WITH COLLABORATORS AT THE UW PUBLISHED FINDINGS IN THE JOURNAL OF EXPERIMENTAL MEDICINE THAT ILLUSTRATE A NOVEL MECHANISM FOR THE ROLE OF REGULATORY T CELLS (TREGS) IN MAINTAINING BALANCE IN A HEALTHY IMMUNE SYSTEM. TREGS PREVENT THE IMMUNE SYSTEM FROM OVERREACTING TO HARMLESS SUBSTANCES AND FROM REACTING TO THE BODY'S OWN CELLS, WHICH LEADS TO AUTOIMMUNITY. WHILE SEVERAL MECHANISMS FOR HOW TREGS SUPPRESS IMMUNE SYSTEM ACTIVATION HAVE BEEN PROPOSED, THE MOLECULAR CHANGES THAT TREGS INDUCE TO SUPPRESS THE IMMUNE RESPONSE HAVE PREVIOUSLY REMAINED UNCLEAR. THE NEW RESULTS SHOWED THAT WHEN TREGS INTERACT WITH CD4 EFFECTOR T CELLS (TEFFS), THE CELLS THAT PROMOTE AN INFLAMMATORY RESPONSE, THEY SUPPRESS PROTEIN SYNTHESIS, PREVENTING CELL DIVISION AND THE PRODUCTION OF MORE TEFFS.STEVEN ZIEGLER, PHD, BRI PRINCIPAL INVESTIGATOR AND CO-AUTHOR ON THE STUDY, NOTED THE RESEARCH FURTHERS UNDERSTANDING OF HOW TREGS WORK IN THE BODY TO MAINTAIN IMMUNE BALANCE.DR. BUCKNER, ALSO A CO-AUTHOR ON THE STUDY, SAID THE RESULTS FURTHER OUR UNDERSTANDING OF HOW TREGS WORK TO CONTROL INFLAMMATION AND HOW WE CAN ENHANCE THEM TO SUPPRESS THE DEVELOPMENT OF AUTOIMMUNE DISEASES.IN RESEARCH PUBLISHED IN SCIENCE IMMUNOLOGY, SCIENTISTS FROM BRI WITH COLLABORATORS AT PENNSYLVANIA STATE UNIVERSITY COLLEGE OF MEDICINE SHOWED THAT THYMIC STROMAL LYMPHOPOIETIN (TSLP) SIGNALING REGULATES GERMINAL CENTER (GC) FUNCTION. DURING AN INFECTION, GCS FORM IN THE SECONDARY LYMPHOID TISSUES, SUCH AS THE LYMPH NODES, TONSILS AND SPLEEN, AMONG OTHER TISSUES. THESE GCS ARE DYNAMIC MICROENVIRONMENTS THAT OPTIMIZE ANTIGEN SPECIFICITY OF B CELLS AND WHOSE ACTIVITY RESULTS IN LONG-LIVED AND HIGH-AFFINITY ANTIBODIES, WHICH ULTIMATELY PROVIDES LONG-TERM IMMUNITY AGAINST INFECTION. YET, THE SIGNALING MOLECULES THAT REGULATE GC FUNCTION ARE STILL BEING IDENTIFIED.STEVEN ZIEGLER, PHD, BRI PRINCIPAL INVESTIGATOR AND CO-AUTHOR ON THE STUDY, SAID THAT IN ADDITION TO IDENTIFYING TSLP AS A NOVEL REGULATOR OF THE GC, THE TEAM WAS ABLE TO DEMONSTRATE HOW THE TSLP SIGNALING PATHWAY IMPACTS B AND T CELL RESPONSES SEPARATELY TO REGULATE THE GC AND THE MAGNITUDE AND QUALITY OF ANTIBODY RESPONSES.PHILLIP DOMEIER, PHD, BRI POST-DOCTORAL SCIENTIST AND CO-AUTHOR ON THE STUDY, NOTED THAT THE STUDY COULD SERVE AS A FOUNDATION FOR FUTURE RESEARCH ON VACCINES, ALLERGIES AND AUTOIMMUNE DISEASES. BRI OVERSEES THE CLINICAL RESEARCH PROGRAM AT VIRGINIA MASON MEDICAL CENTER, UNIQUELY COMBINING THE EXPERTISE OF A WORLD-RENOWNED MEDICAL RESEARCH INSTITUTE WITH THE CARE OF A HEALTHCARE QUALITY LEADER. THE CLINICAL RESEARCH PROGRAM SUPPORTS VIRGINIA MASON CLINICAL INVESTIGATORS IN STUDIES ACROSS A WIDE VARIETY OF AUTOIMMUNE AND IMMUNE-MEDIATED DISEASES AND CONDITIONS, AS WELL AS A BROAD RANGE OF OTHER DISEASES SUCH AS CANCER AND CARDIAC DISEASE. THE CLINICAL RESEARCH PROGRAM STAFF ANNUALLY ENROLLS APPROXIMATELY 2,264 STUDY PARTICIPANTS INTO VIRGINIA MASON TRIALS.ESTABLISHED IN 2023, THE INNOVATION FUND AWARD IS TO BE GIVEN TWICE A YEAR TO INTERNAL RECIPIENTS AT BRI. THE OBJECTIVE IS TO FACILITATE DEVELOPMENT AND IMPLEMENTATION OF NEW TECHNOLOGIES THAT WILL ADVANCE WORK ACROSS OUR INSTITUTION, THROUGH THE FUNDING OF COLLABORATIVE PROJECTS.. EACH AWARD IS TO BE FUNDED FROM PHILANTHROPIC GIFTS.BRI'S REGULAR TRACK AND RESEARCH TRACK FACULTY ARE AWARD ELIGIBLE. PROJECTS ARE REQUIRED TO INCLUDE TWO OR MORE BRI FACULTY AND ADDRESS INNOVATIONS USEFUL TO MULTIPLE RESEARCH GROUPS WITHIN THE INSTITUTE. FURTHER, IT IS REQUIRED THAT THE PROTOCOLS AND RESULTS GENERATED IN THE PROJECT WILL BE MADE AVAILABLE TO ALL BRI INVESTIGATORS. THE FIRST AWARDEES, JOHN RAY, PHD, AND JESSICA HAMERMAN, PHD, DEVELOPED METHODS TO CARRY OUT LARGE GENETIC SCREENS IN SINGLE CELLS FROM THEIR RESPECTIVE LABS AND THROUGH COLLABORATION BETWEEN THE SYSTEMS AND FUNDAMENTAL IMMUNOLOGY CENTERS. THEIR PROJECT BROUGHT TOGETHER TWO MAJOR ADVANCES IN GENOMICS: SINGLE CELL SEQUENCING TO PROFILE MANY DIFFERENT CELLS AT ONCE, AND CRISPR UTILIZED TO MODIFY GENES IN IMMUNE CELLS AND SEE THEIR EFFECTS. THEIR APPROACH ALLOWS US TO UNDERSTAND HOW GENES AND GENE VARIANTS ASSOCIATED WITH COMPLEX DISEASES IMPACT THE IMMUNE SYSTEM AS WELL AS DISEASE PROCESSES IN HUMAN CELLS AND ANIMAL MODELS.
4d Other program services (Describe in Schedule O.)
(Expenses $ 1,948,500 including grants of $ 157,015 ) (Revenue $ 5,702,614 )
4e Total program service expensesMediumBullet69,053,006
Form 990 (2021)
Form 990 (2021)
Page 3
Part IV
Checklist of Required Schedules
Yes
No
1
Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)? If "Yes," complete Schedule AClick to see attachment
List of Attached Documents:
// Content
.....................
1
Yes
 
2
Is the organization required to complete Schedule B, Schedule of Contributors? See instructions. Click to see attachment
List of Attached Documents:
// Content
...
2
Yes
 
3
Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for public office? If "Yes," complete Schedule C, Part IClick to see attachment
List of Attached Documents:
// Content
.............
3
 
No
4
Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect during the tax year? If "Yes," complete Schedule C, Part IIClick to see attachment
List of Attached Documents:
// Content
.........
4
Yes
 
5
Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or similar amounts as defined in Rev. Proc. 98-19? If "Yes," complete Schedule C, Part IIIClick to see attachment
List of Attached Documents:
// Content
..
5
 
No
6
Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part IClick to see attachment
List of Attached Documents:
// Content
.........................
6
 
No
7
Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part IIClick to see attachment
List of Attached Documents:
// Content
....
7
 
No
8
Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes,"
complete Schedule D, Part IIIClick to see attachment
List of Attached Documents:
// Content
..............
8
 
No
9
Did the organization report an amount in Part X, line 21 for escrow or custodial account liability; serve as a custodian for amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services? If "Yes," complete Schedule D, Part IVClick to see attachment
List of Attached Documents:
// Content
..............
9
 
No
10
Did the organization, directly or through a related organization, hold assets in temporarily restricted endowments, permanent endowments, or quasi endowments? If "Yes," complete Schedule D, Part V......
10
 
No
11
If the organization’s answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X, as applicable.
a
Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete
Schedule D, Part VI. Click to see attachment
List of Attached Documents:
// Content
...................
11a
Yes
 
b
Did the organization report an amount for investments—other securities in Part X, line 12 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIClick to see attachment
List of Attached Documents:
// Content
.......
11b
Yes
 
c
Did the organization report an amount for investments—program related in Part X, line 13 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIIIClick to see attachment
List of Attached Documents:
// Content
.......
11c
 
No
d
Did the organization report an amount for other assets in Part X, line 15 that is 5% or more of its total assets reported in Part X, line 16? If "Yes," complete Schedule D, Part IXClick to see attachment
List of Attached Documents:
// Content
............
11d
 
No
e
Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part XClick to see attachment
List of Attached Documents:
// Content
11e
Yes
 
f
Did the organization’s separate or consolidated financial statements for the tax year include a footnote that addresses the organization’s liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part XClick to see attachment
List of Attached Documents:
// Content
11f
Yes
 
12a
Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XIIClick to see attachment
List of Attached Documents:
// Content
......................
12a
 
No
b
Was the organization included in consolidated, independent audited financial statements for the tax year? If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional Click to see attachment
List of Attached Documents:
// Content
12b
Yes
 
13
Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E
13
 
No
14a
Did the organization maintain an office, employees, or agents outside of the United States? .....
14a
 
No
b
Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business, investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000 or more? If "Yes," complete Schedule F, Parts I and IV.........Click to see attachment
List of Attached Documents:
// Content
14b
Yes
 
15
Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any foreign organization? If “Yes,” complete Schedule F, Parts II and IV.....Click to see attachment
List of Attached Documents:
// Content
15
Yes
 
16
Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to or for foreign individuals? If “Yes,” complete Schedule F, Parts III and IV...Click to see attachment
List of Attached Documents:
// Content
16
 
No
17
Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX, column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I. See instructions. ....
17
 
No
18
Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines 1c and 8a? If "Yes," complete Schedule G, Part II............
18
 
No
19
Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes," complete Schedule G, Part III...................
19
 
No
20a
Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H....
20a
 
No
b
If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return?
20b
 
 
21
Did the organization report more than $5,000 of grants or other assistance to any domestic organization or domestic government on Part IX, column (A), line 1? If “Yes,” complete Schedule I, Parts I and II.....Click to see attachment
List of Attached Documents:
// Content
21
Yes
 
Form 990 (2021)
Form 990 (2021)
Page 4
Part IV
Checklist of Required Schedules (continued)
Yes
No
22
Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on Part IX, column (A), line 2? If “Yes,” complete Schedule I, Parts I and III........Click to see attachment
List of Attached Documents:
// Content
22
 
No
23
Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5, about compensation of the organization’s current and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete Schedule J....................... Click to see attachment
List of Attached Documents:
// Content
23
Yes
 
24a
Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the last day of the year, that was issued after December 31, 2002? If “Yes,” answer lines 24b through 24d and complete Schedule K. If “No,” go to line 25a...............Click to see attachment
List of Attached Documents:
// Content
24a
Yes
 
b
Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception?...
24b
 
No
c
Did the organization maintain an escrow account other than a refunding escrow at any time during the year
to defease any tax-exempt bonds? ...............
24c
 
No
d
Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year?...
24d
Yes
 
25a
Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I ....
25a
 
No
b
Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and that the transaction has not been reported on any of the organization’s prior Forms 990 or 990-EZ? If "Yes," complete Schedule L, Part I.......................
25b
 
No
26
Did the organization report any amount on Part X, line 5 or 22 for receivables from or payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II...........
26
 
No
27
Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or employee thereof, a grant selection committee member, or to a 35% controlled entity (including an employee thereof) or family member of any of these persons?
If "Yes," complete
Schedule L, Part III.........................
27
 
No
28
Was the organization a party to a business transaction with one of the following parties (see the Schedule L, Part IV instructions for applicable filing thresholds, conditions, and exceptions):
a
A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If "Yes," complete Schedule L, Part IV......................
28a
 
No
b
A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV.....
28b
 
No
c
A 35% controlled entity of one or more individuals and/or organizations described in line 28a or 28b? If "Yes," complete Schedule L, Part IV.....................
28c
 
No
29
Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M..
29
 
No
30
Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation contributions? If "Yes," complete Schedule M .................
30
 
No
31
Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I
31
 
No
32
Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete Schedule N, Part II........................
32
 
No
33
Did the organization own 100% of an entity disregarded as separate from the organization under Regulations sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I............Click to see attachment
List of Attached Documents:
// Content
33
 
No
34
Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and Part V, line 1.........................Click to see attachment
List of Attached Documents:
// Content
34
Yes
 
35a
Did the organization have a controlled entity within the meaning of section 512(b)(13)?
35a
 
No
b
If ‘Yes’ to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ...
35b
 
 
36
Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization? If "Yes," complete Schedule R, Part V, line 2............. Click to see attachment
List of Attached Documents:
// Content
36
 
No
37
Did the organization conduct more than 5% of its activities through an entity that is not a related organization and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VIClick to see attachment
List of Attached Documents:
// Content
37
 
No
38
Did the organization complete Schedule O and provide explanations on Schedule O for Part VI, lines 11b and 19? Note. All Form 990 filers are required to complete Schedule O. ............
38
Yes
 
Part V
Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V...........
Yes
No
1a
Enter the number reported in box 3 of Form 1096. Enter -0- if not applicable ..
1a
46
b
Enter the number of Forms W-2G included on line 1a. Enter -0- if not applicable .
1b
0
c
Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming (gambling) winnings to prize winners? ..................
1c
Yes
 
Form 990 (2021)
Form 990 (2021)
Page 5
Part V
Statements Regarding Other IRS Filings and Tax Compliance (continued)
2a
Enter the number of employees reported on Form W-3, Transmittal of Wage and
Tax Statements, filed for the calendar year ending with or within the year covered by this return ..................
2a
353
b
If at least one is reported on line 2a, did the organization file all required federal employment tax returns?
Note. If the sum of lines 1a and 2a is greater than 250, you may be required to e-file. See instructions.
2b
Yes
 
3a
Did the organization have unrelated business gross income of $1,000 or more during the year?...
3a
 
No
b
If “Yes,” has it filed a Form 990-T for this year? If “No” to line 3b, provide an explanation in Schedule O...
3b
 
 
4a
At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a financial account in a foreign country (such as a bank account, securities account, or other financial account)? ..
4a
 
No
b
If "Yes," enter the name of the foreign country: MediumBullet
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).
5a
Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ..
5a
 
No
b
Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?
5b
 
No
c
If "Yes," to line 5a or 5b, did the organization file Form 8886-T? ............
5c
 
 
6a
Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit any contributions that were not tax deductible as charitable contributions? ...
6a
 
No
b
If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts were not tax deductible? ......................
6b
 
 
7
Organizations that may receive deductible contributions under section 170(c).
a
Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? ....................
7a
 
No
b
If "Yes," did the organization notify the donor of the value of the goods or services provided? .....
7b
 
 
c
Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required to file Form 8282? .........................
7c
 
No
d
If "Yes," indicate the number of Forms 8282 filed during the year ....
7d
 
e
Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract?
7e
 
No
f
Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ..
7f
 
No
g
If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required? ......................
7g
 
 
h
If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? ..........................
7h
 
 
8
Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the sponsoring organization have excess business holdings at any time during the year? ........
8
 
 
9
Sponsoring organizations maintaining donor advised funds.
a
Did the sponsoring organization make any taxable distributions under section 4966?........
9a
 
 
b
Did the sponsoring organization make a distribution to a donor, donor advisor, or related person?...
9b
 
 
10
Section 501(c)(7) organizations. Enter:
a
Initiation fees and capital contributions included on Part VIII, line 12 ...
10a
 
b
Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities
10b
 
11
Section 501(c)(12) organizations. Enter:
a
Gross income from members or shareholders .........
11a
 
b
Gross income from other sources. (Do not net amounts due or paid to other sources against amounts due or received from them.) ..........
11b
 
12a
Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041?
12a
 
 
b
If "Yes," enter the amount of tax-exempt interest received or accrued during the year.
12b
 
13
Section 501(c)(29) qualified nonprofit health insurance issuers.
a
Is the organization licensed to issue qualified health plans in more than one state? .........
Note. See the instructions for additional information the organization must report on Schedule O.
13a
 
 
b
Enter the amount of reserves the organization is required to maintain by the states in which the organization is licensed to issue qualified health plans ....
13b
 
c
Enter the amount of reserves on hand ............
13c
 
14a
Did the organization receive any payments for indoor tanning services during the tax year?.....
14a
 
No
b
If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation in Schedule O..
14b
 
 
15
Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or excess parachute payment(s) during the year? ....................
If "Yes," see the instructions and file Form 4720, Schedule N.
15
 
No
16
Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ..
If "Yes," complete Form 4720, Schedule O.
16
 
No
17
Section 501(c)(21) organizations. Did the trust, any disqualified person, or mine operator engage in any activities that would result in the imposition of an excise tax under section 4951, 4952, or 4953? ..
If "Yes," complete Form 6069.
17
 
 
Form 990 (2021)
Form 990 (2021)
Page 6
Part VI
Governance, Management, and Disclosure. For each "Yes" response to lines 2 through 7b below, and for a "No" response to lines 8a, 8b, or 10b below, describe the circumstances, processes, or changes in Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI..............
Section A. Governing Body and Management
Yes
No
1a
Enter the number of voting members of the governing body at the end of the tax year
1a
13
If there are material differences in voting rights among members of the governing body, or if the governing body delegated broad authority to an executive committee or similar committee, explain in Schedule O.
b
Enter the number of voting members included in line 1a, above, who are independent
1b
13
2
Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other officer, director, trustee, or key employee? .................
2
 
No
3
Did the organization delegate control over management duties customarily performed by or under the direct supervision of officers, directors or trustees, or key employees to a management company or other person? .
3
 
No
4
Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? .
4
 
No
5
Did the organization become aware during the year of a significant diversion of the organization’s assets? .
5
 
No
6
Did the organization have members or stockholders? ................
6
Yes
 
7a
Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or more members of the governing body? ....................
7a
Yes
 
b
Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or persons other than the governing body? ...................
7b
Yes
 
8
Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a
The governing body? .......................
8a
Yes
 
b
Each committee with authority to act on behalf of the governing body? ............
8b
Yes
 
9
Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the organization’s mailing address? If "Yes," provide the names and addresses in Schedule O.......
9
 
No
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes
No
10a
Did the organization have local chapters, branches, or affiliates? ............
10a
 
No
b
If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates, and branches to ensure their operations are consistent with the organization's exempt purposes?
10b
 
 
11a
Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? ............................
11a
 
No
b
Describe on Schedule O the process, if any, used by the organization to review this Form 990. .....
12a
Did the organization have a written conflict of interest policy? If "No," go to line 13.......
12a
Yes
 
b
Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ..........................
12b
Yes
 
c
Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe on Schedule O how this was done...................
12c
Yes
 
13
Did the organization have a written whistleblower policy? ...............
13
Yes
 
14
Did the organization have a written document retention and destruction policy? .........
14
Yes
 
15
Did the process for determining compensation of the following persons include a review and approval by independent persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a
The organization’s CEO, Executive Director, or top management official ...........
15a
Yes
 
b
Other officers or key employees of the organization ................
15b
Yes
 
If "Yes" to line 15a or 15b, describe the process on Schedule O. See instructions.
16a
Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a taxable entity during the year? ......................
16a
 
No
b
If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization’s exempt status with respect to such arrangements? ............
16b
 
 
Section C. Disclosure
17
List the states with which a copy of this Form 990 is required to be filedMediumBullet
WA
18
Section 6104 requires an organization to make its Form 1023 (1024 or 1024-A, if applicable), 990, and 990-T (section 501(c)(3)s only) available for public inspection. Indicate how you made these available. Check all that apply.
19
Describe in Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial statements available to the public during the tax year.
20
State the name, address, and telephone number of the person who possesses the organization's books and records:
MediumBulletMICHAEL LABOSIER CFO1201 NINTH AVENUE   SEATTLE,WA98101 (206) 342-6505
Form 990 (2021)
Form 990 (2021)
Page 7
Part VII
Compensation of Officers, Directors,Trustees, Key Employees, Highest Compensated Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII..............
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization’s tax year.
RoundBullet List all of the organization’s current officers, directors, trustees (whether individuals or organizations), regardless of amount
of compensation. Enter -0- in columns (D), (E), and (F) if no compensation was paid.

RoundBullet List all of the organization’s current key employees, if any. See the instructions for definition of "key employee."
RoundBullet List the organization’s five current highest compensated employees (other than an officer, director, trustee or key employee)
who received reportable compensation (box 5 of Form W-2, Form 1099-MISC, and/or box 1 of Form 1099-NEC) of more than $100,000 from the
organization and any related organizations.

RoundBullet List all of the organization’s former officers, key employees, or highest compensated employees who received more than $100,000
of reportable compensation from the organization and any related organizations.

RoundBullet List all of the organization’s former directors or trustees that received, in the capacity as a former director or trustee of the
organization, more than $10,000 of reportable compensation from the organization and any related organizations.

See the instructions for the order in which to list the persons above.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A)
Name and title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W-2/1099-MISC/1099-NEC) 		(E)
Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(1) KETUL PATEL......................................................................
CHIEF EXECUTIVE OFFICER VMFH
 10.00
.................
2.00 		    X       3,067,968 0 29,536
(2) JANE BUCKNER MD......................................................................
PRESIDENT
 40.00
.................
0.00 		    X       542,818 0 28,212
(3) MARGARET MCCORMICK PHD......................................................................
EXECUTIVE DIRECTOR & COO
 40.00
.................
0.00 		    X       291,304 0 31,548
(4) WILLIAM KWOK PHD......................................................................
RESEARCH MEMBER
 40.00
.................
0.00 		        X   275,293 0 30,612
(5) STEVEN ZIEGLER PHD......................................................................
DIRECTOR, ACADEMIC AFFAIRS
 40.00
.................
0.00 		        X   265,710 0 25,235
(6) MICHAEL LABOSIER......................................................................
CFO
 40.00
.................
0.00 		    X       222,274 0 33,674
(7) DANIEL CAMPBELL PHD......................................................................
DIRECTOR, CENTER FOR FUNDAMENTAL IMMUNOLOGY
 40.00
.................
0.00 		        X   221,949 0 20,034
(8) CARMEN MIKACENIC MD......................................................................
ASSOCIATE RESEARCH MEMBER
 40.00
.................
0.00 		        X   216,914 0 27,748
(9) JAMES LORD......................................................................
RESEARCH ASSISTANT MEMBER
 40.00
.................
0.00 		        X   213,844 0 24,228
(10) BOB CARLILE......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
(11) ULI CHI PHD......................................................................
DIRECTOR/CHAIR
 2.00
.................
2.00 		X   X       0 0 0
(12) SISTER JUDE CONNELLY OSF......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
(13) CAROLYN CORVI......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
(14) SISTER RUTH GOODWIN OSF......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
(15) TOD HAMACHEK......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
(16) MICHAEL HOFFMAN......................................................................
DIRECTOR (THRU 12/31/22)
 2.00
.................
2.00 		X           0 0 0
(17) DENNIS HUNTHAUSEN......................................................................
DIRECTOR
 2.00
.................
2.00 		X           0 0 0
Form 990 (2021)
Form 990 (2021)
Page 8
Part VII
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A)
Name and title 		(B)
Average hours per week (list any hours for related organizations below dotted line) 		(C)
Position (do not check more than one box, unless person is both an officer and a director/trustee) 		(D)
Reportable compensation from the organization (W-2/1099-MISC/1099-NEC) 		(E)
Reportable compensation from related organizations (W-2/1099-MISC/1099-NEC) 		(F)
Estimated amount of other compensation from the organization and related organizations
Individual Trustee or Director; Institutional Trustee; OfficerInd; Key Employee; Highest compensated employee; FormerOfcrDirectorTrusteeInd;
(18) KAREN LEE........................................................................
DIRECTOR
 2.00
.......................2.00 		X           0 0 0
(19) ROBERT LEMON........................................................................
DIRECTOR/VICE CHAIR
 2.00
.......................2.00 		X   X       0 0 0
(20) GREGG MEYER MD MSC........................................................................
DIRECTOR
 2.00
.......................2.00 		X           0 0 0
(21) JOHN OPPENHEIMER........................................................................
DIRECTOR
 2.00
.......................2.00 		X           0 0 0
(22) MARVIN O'QUINN........................................................................
DIRECTOR
 2.00
.......................2.00 		X           0 0 0
(23) DIANN PULS........................................................................
DIRECTOR
 2.00
.......................2.00 		X           0 0 0
(24) MIRIAM CHAMBLISS........................................................................
CORPORATE SECRETARY / VP DIV GENERAL COUNSEL
 2.00
.......................2.00 		    X       0 0 0
(25) DAVID NOSACKA........................................................................
TREASURER / SVP & CFO VMFH
 0.00
.......................2.00 		    X       0 0 0










1b Sub-Total................MediumBullet
c Total from continuation sheets to Part VII, Section A....MediumBullet
d Total (add lines 1b and 1c)...........MediumBullet 5,318,074 0 250,827
2
Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable compensation from the organization MediumBullet80
Yes
No
3
Did the organization list any former officer, director or trustee, key employee, or highest compensated employee on line 1a? If "Yes," complete Schedule J for such individual ..............
3
 
No
4
For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization and related organizations greater than $150,000? If "Yes," complete Schedule J for such
individual...........................
4
Yes
 
5
Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services rendered to the organization? If "Yes," complete Schedule J for such person ........
5
Yes
 
Section B. Independent Contractors
1
Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from the organization. Report compensation for the calendar year ending with or within the organization’s tax year.
(A)
Name and business address 		(B)
Description of services 		(C)
Compensation
INFINITY BIOLOGIX LLC

PO BOX 23532
NEW YORK,NY100873532 		LABORATORY SERVICES 565,530
NORTH FORK HOLDNGS LLC

1933 N MEACHAM RD STE 220
SCHAUMBURG,IL60173 		IT CONSULTING SERVICES 123,571
DAVIS WRIGHT TREMAINE

920 FIFTH AVE SUITE 3300
SEATTLE,WA981041610 		LEGAL SERVICES 113,661
2
Total number of independent contractors (including but not limited to those listed above) who received more than $100,000 of compensation from the organization MediumBullet3
Form 990 (2021)
Form 990 (2021)
Page 9
Part VIII
Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII.............
(A)
Total revenue 		(B)
Related or
exempt
function
revenue 		(C)
Unrelated
business
revenue 		(D)
Revenue
excluded from
tax under sections
512 - 514
Contributions, Gifts, Grants, and OtherAmt Similar Amounts 1a Federated campaigns..1a  
b Membership dues..1b  
c Fundraising events..1c  
d Related organizations1d  
e Government grants (contributions)1e 57,335,563
f All other contributions, gifts, grants, and similar amounts not included above1f 18,435,751
g Noncash contributions included in lines 1a - 1f:$ 1g  
h Total. Add lines 1a-1f.......MediumBullet 75,771,314
Program Service RevenueAmt Business Code
2a COMMERCIAL STUDIES 621500 4,631,252 4,631,252 0 0
b EXTERNAL CORE INCOME 621500 1,071,362 1,071,362 0 0
c
d
e
f All other program service revenue.        
g Total. Add lines 2a–2f .....MediumBullet 5,702,614
OtherAmtRevenueAmt 3 Investment income (including dividends, interest, and othersimilar amounts) ......MediumBullet 221,304     221,304
4 Income from investment of tax-exempt bond proceedsMediumBullet        
5 Royalties...........MediumBullet        
(ii) Personal (i) Real
6a Gross rents   708,503 6a
b Less: rental expenses   0 6b
c Rental income or (loss)   708,503 6c
d Net rental income or (loss).......MediumBullet 708,503     708,503
(ii) Other (i) Securities
7a Gross amount from sales of assets other than inventory   73,320 7a
b Less: cost or other basis and sales expenses 11,812 0 7b
c Gain or (loss) -11,812 73,320 7c
d Net gain or (loss).........MediumBullet 61,508     61,508
8a Gross income from fundraising events (not including $   of contributions reported on line 1c). See Part IV, line 18 ....
8a  
b Less: direct expenses ... 8b  
c Net income or (loss) from fundraising events..MediumBullet      
9a Gross income from gaming activities.
See Part IV, line 19 ...
9a  
b Less: direct expenses ... 9b  
c Net income or (loss) from gaming activities..MediumBullet        
10a Gross sales of inventory, less
returns and allowances ..
10a  
b Less: cost of goods sold .. 10b  
c Net income or (loss) from sales of inventory..MediumBullet        
Business Code Miscellaneous Revenue
11a            
b            
c            
d All other revenue ....        
e Total. Add lines 11a–11d ...... MediumBullet  
12 Total revenue. See instructions.....MediumBullet 82,465,243 5,702,614 0 991,315
Form 990 (2021)
Form 990 (2021)
Page 10
Part IX
Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).Check if Schedule O contains a response or note to any line in this Part IX..............
Do not include amounts reported on lines 6b,
7b, 8b, 9b, and 10b of Part VIII. 		(A)
Total expenses 		(B)
Program service expenses 		(C)
Management and general expenses 		(D)
Fundraising
expenses
1 Grants and other assistance to domestic organizations and domestic governments. See Part IV, line 21 .... 29,385,333 29,385,333
2 Grants and other assistance to domestic individuals. See Part IV, line 22 ...........    
3 Grants and other assistance to foreign organizations, foreign governments, and foreign individuals. See Part IV, lines 15 and 16. ............. 2,377,475 2,377,475
4 Benefits paid to or for members .......    
5 Compensation of current officers, directors, trustees, and key employees ........... 1,350,348 721,434 628,914  
6 Compensation not included above, to disqualified persons (as defined under section 4958(f)(1)) and persons described in section 4958(c)(3)(B) .........        
7 Other salaries and wages........ 24,832,360 17,432,538 7,399,822  
8 Pension plan accruals and contributions (include section 401(k) and 403(b) employer contributions) .... 2,176,220 1,492,422 683,798  
9 Other employee benefits ....... 4,085,116 2,801,517 1,283,599  
10 Payroll taxes ........... 1,882,163 1,290,762 591,401  
11 Fees for services (non-employees):        
a Management ......        
b Legal ......... 17,780   17,780  
c Accounting ...........        
d Lobbying ...........        
e Professional fundraising services. See Part IV, line 17    
f Investment management fees ......        
g Other (If line 11g amount exceeds 10% of line 25, column (A) amount, list line 11g expenses on Schedule O) 2,785,558 2,271,324 514,234  
12 Advertising and promotion .... 5,012 12 5,000  
13 Office expenses ....... 81,078 19,722 61,356  
14 Information technology ...... 2,116,340 828,792 1,287,548  
15 Royalties ..        
16 Occupancy ........... 3,356,020 2,840,776 515,244  
17 Travel ............ 326,310 281,250 45,060  
18 Payments of travel or entertainment expenses for any federal, state, or local public officials .        
19 Conferences, conventions, and meetings .... 102,669 84,402 18,267  
20 Interest ........... 911,481 792,989 118,492  
21 Payments to affiliates .......        
22 Depreciation, depletion, and amortization .. 1,159,407 982,409 176,998  
23 Insurance ... 203,971 63,314 140,657  
24 Other expenses. Itemize expenses not covered above (List miscellaneous expenses in line 24e. If line 24e amount exceeds 10% of line 25, column (A) amount, list line 24e expenses on Schedule O.)
a MEDICAL SUPPLIES 3,928,476 3,837,397 91,079 0
b PATIENT COSTS 1,167,239 1,167,239 0 0
c MISCELLANEOUS EXPENSES 501,383 66,903 434,480 0
d OTHER PURCHASED SERVICE 364,934 105,948 258,986 0
e All other expenses 210,314 209,048 1,266  
25 Total functional expenses. Add lines 1 through 24e 83,326,987 69,053,006 14,273,981 0
26 Joint costs. Complete this line only if the organization reported in column (B) joint costs from a combined educational campaign and fundraising solicitation. Check here MediumBullet if following SOP 98-2 (ASC 958-720).        
Form 990 (2021)
Form 990 (2021)
Page 11
Part X
Balance Sheet
Check if Schedule O contains a response or note to any line in this Part IX..............
(A)
Beginning of year 		(B)
End of year
Assets 1 Cash–non-interest-bearing ........ 5,284,443 1 8,265,497
2 Savings and temporary cash investments ......... 265,617 2 1,478,988
3 Pledges and grants receivable, net ...... 12,547,565 3 8,245,451
4 Accounts receivable, net ............. 2,609,477 4 984,414
5 Loans and other receivables from any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .......
  5 0
6 Loans and other receivables from other disqualified persons (as defined under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ...
  6 0
7 Notes and loans receivable, net ...........   7 0
8 Inventories for sale or use ............   8 0
9 Prepaid expenses and deferred charges ...... 933,865 9 937,229
10a Land, buildings, and equipment: cost or other basis. Complete Part VI of Schedule D 10a 30,996,619
b Less: accumulated depreciation 10b 2,369,584 28,368,284 10c 28,627,035
11 Investments—publicly traded securities . 4,828,401 11 11,284,790
12 Investments—other securities. See Part IV, line 11 ..... 43,567,602 12 33,041,866
13 Investments—program-related. See Part IV, line 11 ..   13 0
14 Intangible assets ...............   14 0
15 Other assets. See Part IV, line 11 ........... 1,737,804 15 1,489,093
16 Total assets. Add lines 1 through 15 (must equal line 33)... 100,143,058 16 94,354,363
Liabilities 17 Accounts payable and accrued expenses ..... 5,302,398 17 6,437,799
18 Grants payable ...   18 0
19 Deferred revenue ......... 8,974,466 19 6,319,599
20 Tax-exempt bond liabilities ......... 28,998,108 20 28,272,047
21 Escrow or custodial account liability. Complete Part IV of Schedule D   21 0
22 Loans and other payables to any current or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35% controlled entity or family member of any of these persons .........
  22 0
23 Secured mortgages and notes payable to unrelated third parties ..   23 0
24 Unsecured notes and loans payable to unrelated third parties ..   24 0
25 Other liabilities (including federal income tax, payables to related third parties, and other liabilities not included on lines 17 - 24). Complete Part X of Schedule D 2,032,401 25 1,706,233
26 Total liabilities. Add lines 17 through 25.. 45,307,373 26 42,735,678
Net Assets or Fund Balance Organizations that follow FASB ASC 958, check here MediumBullet and complete lines 27, 28, 32, and 33.
27 Net assets without donor restrictions .......... 17,597,685 27 16,899,685
28 Net assets with donor restrictions ........... 37,238,000 28 34,719,000
Organizations that do not follow FASB ASC 958, check here MediumBullet and complete lines 29 through 33.
29 Capital stock or trust principal, or current funds .....   29  
30 Paid-in or capital surplus, or land, building or equipment fund ...   30  
31 Retained earnings, endowment, accumulated income, or other funds   31  
32 Total net assets or fund balances ........... 54,835,685 32 51,618,685
33 Total liabilities and net assets/fund balances ........ 100,143,058 33 94,354,363
Form 990 (2021)
Form 990 (2021)
Page 12
Part XI
Reconcilliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI..............
1
Total revenue (must equal Part VIII, column (A), line 12) ............
1
82,465,243
2
Total expenses (must equal Part IX, column (A), line 25) ............
2
83,326,987
3
Revenue less expenses. Subtract line 2 from line 1 ..............
3
-861,744
4
Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ..
4
54,835,685
5
Net unrealized gains (losses) on investments ...............
5
-2,355,256
6
Donated services and use of facilities .................
6
 
7
Investment expenses .....................
7
 
8
Prior period adjustments .....................
8
 
9
Other changes in net assets or fund balances (explain in Schedule O) ........
9
0
10
Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32, column (B))
10
51,618,685
Part XII
Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII.............
Yes
No
1
Accounting method used to prepare the Form 990:  
If the organization changed its method of accounting from a prior year or checked "Other," explain on
Schedule O.
2a
Were the organization’s financial statements compiled or reviewed by an independent accountant?
2a
 
No
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were compiled or reviewed on a separate basis, consolidated basis, or both:
b
Were the organization’s financial statements audited by an independent accountant?
2b
Yes
 
If ‘Yes,’ check a box below to indicate whether the financial statements for the year were audited on a separate basis, consolidated basis, or both:
c
If "Yes," to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit, review, or compilation of its financial statements and selection of an independent accountant?
2c
Yes
 
If the organization changed either its oversight process or selection process during the tax year, explain in Schedule O.
3a
As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the Single Audit Act and OMB Circular A-133?
3a
Yes
 
b
If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit or audits, explain why in Schedule O and describe any steps taken to undergo such audits.
3b
Yes
 
Form 990 (2021)
Form 990 (2021)
Additional Data


Software ID:  
Software Version:  
Form 990, Special Condition Description:
Special Condition Description
SCHEDULE A
(Form 990)

Department of the Treasury
Internal Revenue Service
Public Charity Status and Public Support
Complete if the organization is a section 501(c)(3) organization or a section 4947(a)(1) nonexempt charitable trust.
right arrow Attach to Form 990 or Form 990-EZ.
right arrow Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2022
Open to Public
Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I
Reason for Public Charity Status (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)
1
2
3
4
5
6
7
8
9
10
11
12
a
b
c
d
e
f
Enter the number of supported organizations ...............................  
g
Provide the following information about the supported organization(s).
(i) Name of supported organization (ii) EIN (iii) Type of organization (described on lines 1- 10 above (see instructions)) (iv) Is the organization listed in your governing document? (v) Amount of monetary support (see instructions) (vi) Amount of other support (see instructions)
Yes No
Total
 
   
For Paperwork Reduction Act Notice, see the Instructions for
Form 990 or 990-EZ.
Cat. No. 11285F
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 2
Part II
Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization failed to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) 2022 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") .. 62,867,601 60,664,155 34,152,956 78,966,994 75,771,314 312,423,020
2 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf....            
3 The value of services or facilities furnished by a governmental unit to the organization without charge..            
4 Total. Add lines 1 through 3 62,867,601 60,664,155 34,152,956 78,966,994 75,771,314 312,423,020
5 The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) .. 21,441,891
6 Public support. Subtract line 5 from line 4. 290,981,129
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) 2022 (f) Total
7 Amounts from line 4.. 62,867,601 60,664,155 34,152,956 78,966,994 75,771,314 312,423,020
8 Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... 945,520 1,174,418 525,133 8,844,594 929,807 12,419,472
9 Net income from unrelated business activities, whether or not the business is regularly carried on..            
10 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. 9,656,398 6,105,766 3,157,242 5,286,187 5,702,614 29,908,207
11 Total support. Add lines 7 through 10 354,750,699
12
12
 
13
First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here ........................................right arrow
Section C. Computation of Public Support Percentage
14
14
82.020 %
15
15
80.750 %
16a
33 1/3% support test—2022. If the organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box
and stop here. The organization qualifies as a publicly supported organization .......................right arrow
b
33 1/3% support test—2021. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this
box and stop here. The organization qualifies as a publicly supported organization ..................... right arrow
17a
10%-facts-and-circumstances test—2022. If the organization did not check a box on line 13, 16a, or 16b, and line 14 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported organization ............ right arrow
b
10%-facts-and-circumstances test—2021. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line 15 is 10% or more, and if the organization meets the "facts-and-circumstances" test, check this box and stop here. Explain in Part VI how the organization meets the "facts-and-circumstances" test. The organization qualifies as a publicly supported organization ............ right arrow
18
Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see
instructions ..................................................... right arrow
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 3
Part III
Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to qualify under the tests listed below, please complete Part II.)
Section A. Public Support
Calendar year (or fiscal year beginning in) right arrow (a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) 2022 (f) Total
1 Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") .            
2 Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose            
3 Gross receipts from activities that are not an unrelated trade or business under section 513 .....            
4 Tax revenues levied for the organization's benefit and either paid to or expended on its behalf...            
5 The value of services or facilities furnished by a governmental unit to the organization without charge            
6 Total. Add lines 1 through 5            
7a Amounts included on lines 1, 2, and 3 received from disqualified persons            
b Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year.            
c Add lines 7a and 7b..            
8 Public support. (Subtract line 7c from line 6.)  
Section B. Total Support
Calendar year (or fiscal year beginning in) right arrow (a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) 2022 (f) Total
9 Amounts from line 6...            
10a Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources..            
b Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975.            
c Add lines 10a and 10b.            
11 Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on.            
12 Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) ..            
13 Total support. (Add lines 9, 10c, 11, and 12.)..            
14
First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization, check this box and stop here................................................. right arrow
Section C. Computation of Public Support Percentage
15
15
 
16
16
 
Section D. Computation of Investment Income Percentage
17
17
 
18
18
 
19a
33 1/3% support tests-2022. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ....... right arrow
b
33 1/3% support tests—2021. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3% and line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ..... right arrow
20
Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions .... right arrow
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 4
Part IV
Supporting Organizations
(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, of Part I, complete Sections A and B. If you checked box 12b, of Part I, complete Sections A and C. If you checked box 12c, of Part I, complete Sections A, D, and E. If you checked box12d, of Part I, complete Sections A and D, and complete Part V.)
Section A. All Supporting Organizations
Yes
No
1
Are all of the organization’s supported organizations listed by name in the organization’s governing documents?
If "No," describe in Part VI how the supported organizations are designated. If designated by class or purpose,
describe the designation. If historic and continuing relationship, explain.
1
 
 
2
Did the organization have any supported organization that does not have an IRS determination of status under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported organization was described in section 509(a)(1) or (2).
2
 
 
3a
Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer lines 3b and 3c below.
3a
 
 
b
Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the organization made the determination.
3b
 
 
c
Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B) purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use.
3c
 
 
4a
Was any supported organization not organized in the United States ("foreign supported organization")? If “Yes” and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below.
4a
 
 
b
Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign supported organization? If “Yes,” describe in Part VI how the organization had such control and discretion despite being controlled or supervised by or in connection with its supported organizations.
4b
 
 
c
Did the organization support any foreign supported organization that does not have an IRS determination under sections 501(c)(3) and 509(a)(1) or (2)? If “Yes,” explain in Part VI what controls the organization used to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B) purposes.
4c
 
 
5a
Did the organization add, substitute, or remove any supported organizations during the tax year? If “Yes,” answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action; (iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action was accomplished (such as by amendment to the organizing document).
5a
 
 
b
Type I or Type II only. Was any added or substituted supported organization part of a class already designated in the organization's organizing document?
5b
 
 
c
Substitutions only. Was the substitution the result of an event beyond the organization's control?
5c
 
 
6
Did the organization provide support (whether in the form of grants or the provision of services or facilities) to anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class benefited by one or more of its supported organizations, or (iii) other supporting organizations that also support or benefit one or more of the filing organization’s supported organizations? If “Yes,” provide detail in Part VI.
6
 
 
7
Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor (defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with regard to a substantial contributor? If “Yes,” complete Part I of Schedule L (Form 990) .
7
 
 
8
Did the organization make a loan to a disqualified person (as defined in section 4958) not described on line 7? If “Yes,” complete Part I of Schedule L (Form 990).
8
 
 
9a
Was the organization controlled directly or indirectly at any time during the tax year by one or more disqualified persons, as defined in section 4946 (other than foundation managers and organizations described in section 509(a)(1) or (2))? If “Yes,” provide detail in Part VI.
9a
 
 
b
Did one or more disqualified persons (as defined on line 9a) hold a controlling interest in any entity in which the supporting organization had an interest? If “Yes,” provide detail in Part VI.
9b
 
 
c
Did a disqualified person (as defined on line 9a) have an ownership interest in, or derive any personal benefit from, assets in which the supporting organization also had an interest? If “Yes,” provide detail in Part VI.
9c
 
 
10a
Was the organization subject to the excess business holdings rules of section 4943 because of section 4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated supporting organizations)? If “Yes,” answer line 10b below.
10a
 
 
b
Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to determine whether the organization had excess business holdings).
10b
 
 
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 5
Part IV
Supporting Organizations (continued)
Yes
No
11
Has the organization accepted a gift or contribution from any of the following persons?
a
A person who directly or indirectly controls, either alone or together with persons described on lines 11b and 11c below, the governing body of a supported organization?
11a
 
 
b
A family member of a person described on 11a above?
11b
 
 
c
A 35% controlled entity of a person described on line 11a or 11b above? If “Yes” to 11a, 11b, or 11c, provide detail in Part VI.
11c
 
 
Section B. Type I Supporting Organizations
Yes
No
1
Did the officers, directors, trustees, or membership of one or more supported organizations have the power to regularly appoint or elect at least a majority of the organization’s directors or trustees at all times during the tax year? If “No,” describe in Part VI how the supported organization(s) effectively operated, supervised, or controlled the organization’s activities. If the organization had more than one supported organization, describe how the powers to appoint and/or remove directors or trustees were allocated among the supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year.
1
 
 
2
Did the organization operate for the benefit of any supported organization other than the supported organization(s) that operated, supervised, or controlled the supporting organization? If “Yes,” explain in Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated, supervised or controlled the supporting organization.
2
 
 
Section C. Type II Supporting Organizations
Yes
No
1
Were a majority of the organization’s directors or trustees during the tax year also a majority of the directors or trustees of each of the organization’s supported organization(s)? If “No,” describe in Part VI how control or management of the supporting organization was vested in the same persons that controlled or managed the supported organization(s).
1
 
 
Section D. All Type III Supporting Organizations
Yes
No
1
Did the organization provide to each of its supported organizations, by the last day of the fifth month of the organization’s tax year, (i) a written notice describing the type and amount of support provided during the prior tax year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the organization’s governing documents in effect on the date of notification, to the extent not previously provided?
1
 
 
2
Were any of the organization’s officers, directors, or trustees either (i) appointed or elected by the supported organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how the organization maintained a close and continuous working relationship with the supported organization(s).
2
 
 
3
By reason of the relationship described in line 2 above, did the organization’s supported organizations have a significant voice in the organization’s investment policies and in directing the use of the organization’s income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization’s supported organizations played in this regard.
3
 
 
Section E. Type III Functionally-Integrated Supporting Organizations
1
Check the box next to the method that the organization used to satisfy the Integral Part Test during the year (see instructions):
a
b
c
2
Activities Test. Answer lines 2a and 2b below.
Yes
No
a
Did substantially all of the organization’s activities during the tax year directly further the exempt purposes of the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify those supported organizations and explain how these activities directly furthered their exempt purposes, how the organization was responsive to those supported organizations, and how the organization determined that these activities constituted substantially all of its activities.
2a
 
 
b
Did the activities described on line 2a, above constitute activities that, but for the organization’s involvement, one or more of the organization’s supported organization(s) would have been engaged in? If "Yes," explain in Part VI the reasons for the organization’s position that its supported organization(s) would have engaged in these activities but for the organization’s involvement.
2b
 
 
3
Parent of Supported Organizations. Answer lines 3a and 3b below.
a
Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or trustees of each of the supported organizations?If "Yes" or "No", provide details in Part VI.
3a
 
 
b
Did the organization exercise a substantial degree of direction over the policies, programs and activities of each of its supported organizations? If "Yes," describe in Part VI. the role played by the organization in this regard.
3b
 
 
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 6
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations
1
Section A - Adjusted Net Income (A) Prior Year (B) Current Year
(optional)
1 Net short-term capital gain 1    
2 Recoveries of prior-year distributions 2    
3 Other gross income (see instructions) 3    
4 Add lines 1 through 3 4    
5 Depreciation and depletion 5    
6 Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) 6    
7 Other expenses (see instructions) 7    
8 Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) 8    
Section B - Minimum Asset Amount (A) Prior Year (B) Current Year
(optional)
1 Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): 1
a Average monthly value of securities 1a    
b Average monthly cash balances 1b    
c Fair market value of other non-exempt-use assets 1c    
d Total (add lines 1a, 1b, and 1c) 1d    
e Discount claimed for blockage or other factors
(explain in detail in Part VI):  
2 Acquisition indebtedness applicable to non-exempt use assets 2    
3 Subtract line 2 from line 1d 3    
4 Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions). 4    
5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5    
6 Multiply line 5 by 0.035 6    
7 Recoveries of prior-year distributions 7    
8 Minimum Asset Amount (add line 7 to line 6) 8    
Section C - Distributable Amount Current Year
1 Adjusted net income for prior year (from Section A, line 8, Column A) 1  
2 Enter 85% of line 1 2  
3 Minimum asset amount for prior year (from Section B, line 8, Column A) 3  
4 Enter greater of line 2 or line 3 4  
5 Income tax imposed in prior year 5  
6 Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) 6  
7
Schedule A (Form 990) 2022

Schedule A (Form 990) 2022
Page 7
Part V
Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations(continued)
Section D - Distributions Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes 1  
2 Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in
excess of income from activity 		2  
3 Administrative expenses paid to accomplish exempt purposes of supported organizations 3  
4 Amounts paid to acquire exempt-use assets 4  
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI) 5  
6 Other distributions (describe in Part VI). See instructions 6  
7Total annual distributions. Add lines 1 through 6. 7  
8 Distributions to attentive supported organizations to which the organization is responsive (provide
details in Part VI). See instructions 		8  
9 Distributable amount for 2022 from Section C, line 6 9  
10 Line 8 amount divided by Line 9 amount 10  
Section E - Distribution Allocations (see instructions) (i)
Excess Distributions 		(ii)
Underdistributions
Pre-2022 		(iii)
Distributable
Amount for 2022
1 Distributable amount for 2022 from Section C, line 6  
2 Underdistributions, if any, for years prior to 2022 (reasonable cause required-- explain in Part VI).
See instructions.		  
3 Excess distributions carryover, if any, to 2022:
a From 2017.......  
b From 2018.......  
c From 2019.......  
d From 2020.......  
e From 2021.......  
fTotal of lines 3a through e  
g Applied to underdistributions of prior years  
h Applied to 2022 distributable amount  
i Carryover from 2017 not applied (see
instructions) 		 
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.  
4Distributions for 2022 from Section D, line 7:
$  
a Applied to underdistributions of prior years  
b Applied to 2022 distributable amount  
c Remainder. Subtract lines 4a and 4b from line 4.  
5 Remaining underdistributions for years prior to
2022, if any. Subtract lines 3g and 4a from line 2.
If the amount is greater than zero, explain in Part VI.
See instructions. 		 
6 Remaining underdistributions for 2022. Subtract
lines 3h and 4b from line 1. If the amount is greater
than zero, explain in Part VI. See instructions. 		 
7 Excess distributions carryover to 2023. Add lines
3j and 4c. 		 
8 Breakdown of line 7:
a Excess from 2018.....  
b Excess from 2019.....  
c Excess from 2020.....  
d Excess from 2021.....  
e Excess from 2022.....  
Schedule A (Form 990) (2022)

Schedule A (Form 990) 2022
Page 8
Part VI
Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12; Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C, line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a and 3b; Part V, line 1; Part V, Section B, line 1e; Part V Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information. (See instructions).
Facts And Circumstances Test
 
Return Reference Explanation
SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: CLINICAL RESEARCH PROGRAM REVENUE - 2018 AMOUNT: $ 4,280,875. 2019 AMOUNT: $ 5,569,393. 2020 AMOUNT: $ 2,665,138. 2021 AMOUNT: $ 4,732,659. 2022 AMOUNT: $ 4,631,252. COLLABORATIVE RESEARCH AGREEMENT PROJECTS - 2018 AMOUNT: $ 4,453,944. EXTERNAL CORE INCOME - 2018 AMOUNT: $ 886,743. 2019 AMOUNT: $ 430,308. 2020 AMOUNT: $ 394,817. 2021 AMOUNT: $ 553,528. 2022 AMOUNT: $ 1,071,362. MISCELLANEOUS INCOME - 2018 AMOUNT: $ 34,836. 2019 AMOUNT: $ 106,065. 2020 AMOUNT: $ 97,287.
Schedule A (Form 990) 2022


Additional Data


Software ID:  
Software Version:  
Schedule B
(Form 990)
Department of the Treasury
Internal Revenue Service
Schedule of Contributors

Arrow Bullet Attach to Form 990, 990-EZ, or 990-PF.
Arrow Bullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2022
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Organization type (check one):
Filers of:
Section:
Form 990 or 990-EZ






Form 990-PF




Check if your organization is covered by the General Rule or a Special Rule.  
Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
Special Rules
......... Arrow Bullet $  
Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990,
990-EZ, or 990-PF), but it must answer “No” on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ
or on its Form 990PF, Part I, line 2, to certify that it doesn't meet the filing requirements of Schedule B (Form 990,
990-EZ, or 990-PF).
For Paperwork Reduction Act Notice, see the Instructions
for Form 990, 990-EZ, or 990-PF.
Cat. No. 30613XSchedule B (Form 990) (2022)
Schedule B (Form 990) (2022) Page 2
Name of organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON 		Employer identification number
91-0653422
Part I
Contributors
Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
RESTRICTED
 
 
 
 
  ,    

$ RESTRICTED


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
(a)
No.		 (b)
Name, address, and ZIP + 4		 (c)
Total contributions		 (d)
Type of contribution
 
 
 
 

$  


(Complete Part II for noncash contributions.)
Schedule B (Form 990) (2022)
Schedule B (Form 990) (2022)
Page 3
Name of organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON 		Employer identification number

91-0653422
Part II
Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
(a)
No. from Part I 		(b)
Description of noncash property given 		(c)
FMV (or estimate)
(See instructions) 		(d)
Date received
 
$    
Schedule B (Form 990) (2022)
Schedule B (Form 990) (2022)
Page 4
Name of organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON 		Employer identification number

91-0653422
Part III
Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this information once. See instructions.) Arrow Bullet$  
Use duplicate copies of Part III if additional space is needed.
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
(a)
No. from Part I		 (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
 
(e) Transfer of gift
Transferee's name, address, and ZIP 4 Relationship of transferor to transferee
 
 
     
 
Schedule B (Form 990) (2022)
Additional Data


Software ID:  
Software Version:  
SCHEDULE C
(Form 990)

Department of the Treasury
Internal Revenue Service
Political Campaign and Lobbying Activities

For Organizations Exempt From Income Tax Under section 501(c) and section 527

SchCMd Bullet Complete if the organization is described below. SchCMd Bullet Attach to Form 990 or Form 990-EZ.
SchCMd BulletGo to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public
Inspection
If the organization answered "Yes" on Form 990, Part IV, Line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
Round Bullet Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
Round Bullet Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
Round Bullet Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes" on Form 990, Part IV, Line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
Round Bullet Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
Round Bullet Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes" on Form 990, Part IV, Line 5 (Proxy Tax) (see separate instructions) or Form 990-EZ, Part V, line 35c (Proxy Tax) (see separate instructions), then
Round Bullet Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I-A
Complete if the organization is exempt under section 501(c) or is a section 527 organization.

1
Provide a description of the organization’s direct and indirect political campaign activities in Part IV. See instructions for definition of “political campaign activities."

2
Political campaign activity expenditures. See instructions ....................................................................SchCMd Bullet
$  
3
Volunteer hours for political campaign activities. See instructions ..................................................................
 

Part I-B
Complete if the organization is exempt under section 501(c)(3).
1
Enter the amount of any excise tax incurred by the organization under section 4955 ................................SchCMd Bullet
$  
2
Enter the amount of any excise tax incurred by organization managers under section 4955 .......................SchCMd Bullet
$  
3
If the organization incurred a section 4955 tax, did it file Form 4720 for this year? .........................................
4a
Was a correction made? ......................................................................................................................
b
If "Yes," describe in Part IV.
Part I-C
Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1
Enter the amount directly expended by the filing organization for section 527 exempt function activities ..... SchCMd Bullet
$  
2
Enter the amount of the filing organization's funds contributed to other organizations for section 527 exempt function activities ............................................................................................................................SchCMd Bullet

$  
3
Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL, line 17b...........SchCMd Bullet

$  
4
Did the filing organization file Form 1120-POL for this year? ...................................................................
5
Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing
organization made payments. For each organization listed, enter the amount paid from the filing organization’s funds. Also enter the amount of political contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from filing organization's funds. If none, enter -0-. (e) Amount of political contributions received and promptly and directly delivered to a separate political organization. If none, enter -0-.
1
2
3
4
5
6
For Paperwork Reduction Act Notice, see the instructions for Form 990.
Cat. No. 50084S
Schedule C (Form 990) 2021

Schedule C (Form 990) 2021
Page 2
Part II-A
Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under section 501(h)).
A Check SchCMd Bulletexpenses, and share of excess lobbying expenditures).Click to see attachment
List of Attached Documents:
// Content

B Check SchCMd Bullet
Limits on Lobbying Expenditures
(The term "expenditures" means amounts paid or incurred.) 		(a) Filing
organization's
totals 		(b) Affiliated group totals
1a Total lobbying expenditures to influence public opinion (grass roots lobbying) ......................   142,625
b Total lobbying expenditures to influence a legislative body (direct lobbying) ........................   11,240
c Total lobbying expenditures (add lines 1a and 1b) ............................................................   153,865
d Other exempt purpose expenditures ...............................................................................   1,235,710,652
e Total exempt purpose expenditures (add lines 1c and 1d) ..................................................   1,235,864,517
f Lobbying nontaxable amount. Enter the amount from the following table in both
columns.		   1,000,000
If the amount on line 1e, column (a) or (b) is:The lobbying nontaxable amount is:
Not over $500,00020% of the amount on line 1e.
Over $500,000 but not over $1,000,000$100,000 plus 15% of the excess over $500,000.
Over $1,000,000 but not over $1,500,000$175,000 plus 10% of the excess over $1,000,000.
Over $1,500,000 but not over $17,000,000$225,000 plus 5% of the excess over $1,500,000.
Over $17,000,000$1,000,000.
g Grassroots nontaxable amount (enter 25% of line 1f) .................................................   250,000
h Subtract line 1g from line 1a. If zero or less, enter -0-. ................................................   0
i Subtract line 1f from line 1c. If zero or less, enter -0-. ................................................   0
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720 reporting
section 4911 tax for this year? ...................................................................................................................

4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five
columns below. See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
Calendar year (or fiscal year
beginning in) 		(a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) Total
2a Lobbying nontaxable amount 1,000,000 1,000,000 1,000,000 1,000,000 4,000,000
b Lobbying ceiling amount
(150% of line 2a, column(e)) 		6,000,000
c Total lobbying expenditures 209,447 205,420 219,020 153,865 787,752
d Grassroots nontaxable amount 250,000 1,000,000 250,000 250,000 1,750,000
e Grassroots ceiling amount
(150% of line 2d, column (e))		 2,625,000
f Grassroots lobbying expenditures 129,023 126,542 203,020 142,625 601,210
Schedule C (Form 990) 2021


Schedule C (Form 990) 2021
Page 3
Part II-B
Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768 (election under section 501(h)).
For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description of the lobbying activity.
(a)
Yes|No
(b)
Amount
1
During the year, did the filing organization attempt to influence foreign, national, state or local legislation, including any attempt to influence public opinion on a legislative matter or referendum, through the use of:
a
Volunteers? ...........................................................................................................
 
 
b
Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ........
 
 
c
Media advertisements? ...................................................................................................
 
 
 
d
Mailings to members, legislators, or the public? .............................................................................
 
 
 
e
Publications, or published or broadcast statements? ...........................................................
 
 
 
f
Grants to other organizations for lobbying purposes? ..........................................................
 
 
 
g
Direct contact with legislators, their staffs, government officials, or a legislative body? .......................
 
 
 
h
Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ..................
 
 
 
i
Other activities? ...................................................................................................................
 
 
 
j
Total. Add lines 1c through 1i ....................................................................................................
 
2a
Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? .....
 
 
b
If "Yes," enter the amount of any tax incurred under section 4912 ...........................................
 
c
If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ...................
 
d
If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ........................
 
 
Part III-A
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6).
Yes
No
1
Were substantially all (90% or more) dues received nondeductible by members? ...............................................
1
 
 
2
Did the organization make only in-house lobbying expenditures of $2,000 or less? ............................................
2
 
 
3
Did the organization agree to carry over lobbying and political expenditures from the prior year? .................................
3
 
 
Part III-B
Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section 501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is answered “Yes."
1
Dues, assessments and similar amounts from members ......................................................................
1
 
2
Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political expenses for which the section 527(f) tax was paid).
a
Current year .............................................................................................................................
2a
 
b
Carryover from last year ............................................................................................................
2b
 
c
Total ...........................................................................................................................................
2c
 
3
Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues .
3
 
4
If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political expenditure next year? ......................................................................................................................
4
 
5
Taxable amount of lobbying and political expenditures. See Instructions .........................................
5
 
Part IV
Supplemental Information
Provide the descriptions required for Part l-A, line 1; Part l-B, line 4; Part l-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (see instructions), and Part ll-B, line 1. Also, complete this part for any additional information.
Return Reference Explanation
Schedule C (Form 990) 2021


Additional Data


Software ID:  
Software Version:  

SCHEDULE D
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Financial Statements
SchDMd Bullet Complete if the organization answered "Yes," on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
SchDMd Bullet Attach to Form 990.
SchDMd Bullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I
Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts. Complete if the organization answered "Yes" on Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year .........    
2 Aggregate value of contributions to (during year)    
3 Aggregate value of grants from (during year)    
4 Aggregate value at end of year ........    
5
Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds are the organization’s property, subject to the organization’s exclusive legal control? ............
6
Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring impermissible private benefit? ...................................
Part II
Conservation Easements.
Complete if the organization answered "Yes" on Form 990, Part IV, line 7.
1
Purpose(s) of conservation easements held by the organization (check all that apply).
2
Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last day of the tax year.
Held at the End of the Year
a Total number of conservation easements ...................... 2a  
b Total acreage restricted by conservation easements .................... 2b  
c Number of conservation easements on a certified historic structure included in (a) ..... 2c  
d Number of conservation easements included in (c) acquired after 7/25/06, and not on a historic structure listed in the National Register ... 2d  
3
Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the
tax year SchDMd Bullet  
4
Number of states where property subject to conservation easement is located SchDMd Bullet  
5
Does the organization have a written policy regarding the periodic monitoring, inspection, handling of violations, and enforcement of the conservation easements it holds? ............
6
Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet  
7
Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
SchDMd Bullet $  
8
Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i) and section 170(h)(4)(B)(ii)? .............................
9
In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement, and
balance sheet, and include, if applicable, the text of the footnote to the organization’s financial statements that describes
the organization’s accounting for conservation easements.
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.
1a
If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide, in Part XIII, the text of the footnote to its financial statements that describes these items.
b
If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service, provide the following amounts relating to these items:
(i)
Revenue included on Form 990, Part VIII, line 1 .........................SchDMd Bullet $  
(ii)
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
2
If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide the
following amounts required to be reported under FASB ASC 958 relating to these items:
a
Revenue included on Form 990, Part VIII, line 1 ..........................SchDMd Bullet $  
b
Assets included in Form 990, Part X ...............................SchDMd Bullet $  
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 52283D
Schedule D (Form 990) 2021

Schedule D (Form 990) 2021
Page 2
Part III
Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets (continued)
3
Using the organization’s acquisition, accession, and other records, check any of the following that are a significant use of its collection items (check all that apply):
a
d
b
e
 
c
4
Provide a description of the organization’s collections and explain how they further the organization’s exempt purpose in
Part XIII.
5
During the year, did the organization solicit or receive donations of art, historical treasures or other similar
assets to be sold to raise funds rather than to be maintained as part of the organization’s collection?...
Part IV
Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or reported an amount on Form 990, Part X, line 21.
1a
Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not
included on Form 990, Part X? ....................................
b If "Yes," explain the arrangement in Part XIII and complete the following table: Amount
c Beginning balance ............................. 1c  
d Additions during the year ............................ 1d  
e Distributions during the year .......................... 1e  
f Ending balance ................................ 1f  
2a
Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ...
b
If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided in Part XIII ....
Part V
Endowment Funds.
Complete if the organization answered "Yes" on Form 990, Part IV, line 10.
(a) Current year (b) Prior year (c) Two years back (d) Three years back (e) Four years back
1a Beginning of year balance ....          
b Contributions ...          
c Net investment earnings, gains, and losses          
d Grants or scholarships ...          
e Other expenditures for facilities
and programs ... 		         
f Administrative expenses ....          
g End of year balance ......          
2
Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a
Board designated or quasi-endowment SchDMd Bullet  
b
Permanent endowment SchDMd Bullet  
c
Term endowment SchDMd Bullet  
The percentages on lines 2a, 2b, and 2c should equal 100%.
3a
Are there endowment funds not in the possession of the organization that are held and administered for the
organization by:

Yes
No
(i) Unrelated organizations .................
3a(i)
Yes
 
(ii) Related organizations .................
3a(ii)
 
 
b
If "Yes" on 3a(ii), are the related organizations listed as required on Schedule R? .........
3b
 
 
4
Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI
Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other basis
(investment) 		(b) Cost or other basis (other) (c) Accumulated depreciation (d) Book value
1a Land .....   14,110,000 14,110,000
b Buildings ....   12,362,749 864,139 11,498,610
c Leasehold improvements        
d Equipment ....   4,205,998 1,505,445 2,700,553
e Other .....   317,872   317,872
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10(c).)..SchDMdBullet 28,627,035
Schedule D (Form 990) 2021

Schedule D (Form 990) 2021
Page 3
Part VII
Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category
(including name of security)		 (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(1) Financial derivatives.........    
(2) Closely-held equity interests........    
(3) Other
(A) INTEREST IN NET ASSETS OF VIRGINIA MASON MEDICAL CENTER		 33,041,866 F
(B)
(C)
(D)
(E)
(F)
(G)
(H)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 12.)Small Bullet 33,041,866
Part VIII
Investments - Program Related. Complete if the organization answered 'Yes' on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation:
Cost or end-of-year market value
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 13.)Small Bullet  
Part IX
Other Assets.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 15.)...........Small Bullet  
Part X
Other Liabilities.
Complete if the organization answered 'Yes' on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1.(a) Description of liability (b) Book value
(1) Federal income taxes  
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col.(B) line 25.)Small Bullet 1,706,233
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the organization's liability for uncertain tax positions under FIN 48 (ASC 740). Check here if the text of the footnote has been provided in Part XIII
Schedule D (Form 990) 2021

Schedule D (Form 990) 2021
Page 4
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ....... 1  
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains (losses) on investments .... 2a  
b Donated services and use of facilities ......... 2b  
c Recoveries of prior year grants ........... 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d ..................... 2e  
3 Subtract line 2e from line 1.................. 3  
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b . 4a  
b Other (Describe in Part XIII.) ........... 4b  
c Add lines 4a and 4b.................... 4c  
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ...... 5  
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return. Complete if the organization answered 'Yes' on Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ........... 1  
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities ......... 2a  
b Prior year adjustments ............ 2b  
c Other losses ................ 2c  
d Other (Describe in Part XIII.) ............ 2d  
e Add lines 2a through 2d.................... 2e  
3 Subtract line 2e from line 1................... 3  
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b .. 4a  
b Other (Describe in Part XIII.) ............ 4b  
c Add lines 4a and 4b..................... 4c  
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) ...... 5  
Part XIII
Supplemental Information
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part lV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI, lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
Return Reference Explanation
PART X, LINE 2: BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON'S FINANCIAL INFORMATION IS INCLUDED IN COMMONSPIRIT HEALTH'S CONSOLIDATED AUDITED FINANCIAL STATEMENTS, WHICH INCLUDES THE FOLLOWING DISCLOSURE: COMMONSPIRIT REVIEWS ITS TAX POSITIONS QUARTERLY AND HAS DETERMINED THAT THERE ARE NO MATERIAL UNCERTAIN TAX POSITIONS THAT REQUIRE RECOGNITION IN THE ACCOMPANYING CONSOLIDATED FINANCIAL STATEMENTS.
PART X, LINE 1 IN ACCORDANCE WITH ASC TOPIC 842 LEASES, THE RESEARCH INSTITUTE ADOPTED THE LEASE STANDARD AND RECORDED LEASE LIABILITIES OVER THE LEASE TERMS BETWEEN 3 AND 10 YEARS. THE LEASES ARE PRIMARILY FOR REAL ESTATE, INCLUDING OFF-CAMPUS OUTPATIENT FACILITIES, MEDICAL OFFICE BUILDINGS, AND CORPORATE AND ADMINISTRATIVE OFFICES.
PART V ENDOWMENT FUNDS BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON'S (BRI) SOLE CORPORATE MEMBER IS VIRGINIA MASON FRANCISCAN HEALTH (VMFH). VMFH IS A SUPPORTING ORGANIZATION OF BRI AND VIRGINIA MASON MEDICAL CENTER (VMMC). VMMC HOLDS ENDOWMENT FUNDS THAT SUPPORT BRI RESEARCH AIMED AT DIABETES, RHEUMATOLOGY, IMMUNOLOGY, AND OTHER RESEARCH. THE BALANCE OF THESE ENDOWMENTS WAS $36.0 MILLION AND $33.0 MILLION ON JUNE 30, 2022 AND JUNE 30, 2023, RESPECTIVELY.
Schedule D (Form 990) 2021


Additional Data


Software ID:  
Software Version:  




SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990.Right pointing arrow large image Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2022
Open to Public Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in the region (d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in the region		 (f) Total expenditures
for and investments
in the region
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 0 GRANT MEDICAL RESEARCH 2,243,875
EAST ASIA AND THE PACIFIC 0 0 GRANT MEDICAL RESEARCH 133,600
           
           
           
           
           
           
           
           
           
           
           
           
           
           
           
3a Sub-total .... 0 0 2,377,475
b Total from continuation sheets to Part I ... 0 0 0
c Totals (add lines 3a and 3b) 0 0 2,377,475
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2022
Schedule F (Form 990) 2022
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount
of noncash
assistance 		(h) Description
of noncash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
EUROPE (INCLUDING ICELAND AND GREENLAND) GENERAL SUPPORT 325,612 WIRE TRANSFER 0    
EUROPE (INCLUDING ICELAND AND GREENLAND) GENERAL SUPPORT 1,483,977 WIRE TRANSFER 0    
EUROPE (INCLUDING ICELAND AND GREENLAND) GENERAL SUPPORT 46,052 WIRE TRANSFER 0    
EUROPE (INCLUDING ICELAND AND GREENLAND) GENERAL SUPPORT 388,235 WIRE TRANSFER 0    
EAST ASIA AND THE PACIFIC GENERAL SUPPORT 133,600 WIRE TRANSFER 0    
             
             
             
             
             
             
             
             
             
             
             
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
 
3 Enter total number of other organizations or entities .......................MediumBullet
5
Schedule F (Form 990) 2022
Schedule F (Form 990) 2022Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
noncash
assistance 		(g) Description
of noncash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2022
Schedule F (Form 990) 2022
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2022
Schedule F (Form 990) 2022
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
ReturnReference Explanation
PART III ACCOUNTING METHOD:  
PART I, LINE 2: SUB-RECIPIENT MONITORING POLICY -MEDICAL RESEARCH SUB AWARD BRI HAS FORMAL POLICIES AND PRODECURES TO ASSURE FULL COMPLIANCE WITH APPLICABLE POLICIES AND LAWS GOVERNING FEDERAL GRANTS. THE SUB-RECIPIENT MONITORING POLICY PROVIDES ASSURANCE THAT SUB-RECIPIENTS COMPLY WITH FEDERAL GRANT REGULATIONS. THIS POLICY SETS THE CRITERIA TO ESTABLISH ELIGIBILITY OF SUB-RECIPIENTS TO PROVIDE ANNUAL AUDITED FINANCIAL REPORTS AND THE ANNUAL OMB SINGLE AUDIT REPORT THAT IDENTIFY COMPLIANCE WITH FEDERAL LAWS AND REGULATIONS. THE REPORTS ARE ANALYZED WITH EMPHASIS ON AUDITOR'S ASSESSMENT OF SUB-RECIPIENT INTERNAL CONTROLS AND A STANDARDIZED RISK ASSESSMENT IS PRESENTED TO MANAGEMENT ON EACH SUB-RECIPIENT. A MANAGEMENT LETTER IS ISSUED TO EACH SUB-RECIPIENT SHOWING ANY FINDINGS ON THEIR OMB SINGLE AUDIT REPORT, AND MEASUREMENTS ARE SET FOR INCREASED MONITORING WHEN AN ELEVATED LEVEL OF RISK IS ESTABLISHED. MANAGEMENT HAS COMMUICATED WITH AN EDUCATED ADMINISTRATIVE STAFF REGARDING IMPLEMENTATION OF THIS POLICY. THE DIRECTOR OF GRANTS AND CONTRACTS IS RESPONSIBILE FOR MONITORING SUB-RECIPIENT ADHERENCE TO FINANCIAL REGULATIONS. THE PRINCIPAL INVESTIGATOR IS RESPONSIBLE FOR OVERSEEING THE SATISFACTORY PERFORMANCE OF THE SUB-AWARD TO ENSURE THAT GOALS ARE ACHIEVED. IF THERE ARE UNUSUAL OR UNFORESEEN ITEMS, THESE WILL BE INVESTIGATED.
PART 1, LINE 3F THE EXPENDITURES WERE ACTUAL EXPENSES INCURRED IN THE REGION BASED ON INDIVIDUAL EXPENSE REPORTS AND TRACKING OF EXPENDITURES BY GRANT OR DEPARTMENT ON THE ACCRUAL BASIS OF ACCOUNTING.
PART II, LINE 1 THE EXPENDITURES WERE EXPENSES INCURRED IN THE REGION BASED ON AWARD GOALS ON THE ACCRUAL BASIS OF ACCOUNTING.
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2022
Additional Data


Software ID:  
Software Version:  




Note: To capture the full content of this document, please select landscape mode (11" x 8.5") when printing.

Schedule I
(Form 990)
Department of the Treasury
Internal Revenue Service
Grants and Other Assistance to Organizations,
Governments and Individuals in the United States
Complete if the organization answered "Yes," on Form 990, Part IV, line 21 or 22.
lBullet Attach to Form 990.
lBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2022
Open to Public
Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number
91-0653422
Part I
General Information on Grants and Assistance
1
Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and
the selection criteria used to award the grants or assistance? ........................
2
Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II
Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any recipient
that received more than $5,000. Part II can be duplicated if additional space is needed.
(a) Name and address of organization
or government		 (b) EIN (c) IRC section
(if applicable)		 (d) Amount of cash grant (e) Amount of non-cash
assistance		 (f) Method of valuation
(book, FMV, appraisal,
other)		 (g) Description of
noncash assistance		 (h) Purpose of grant
or assistance
(1) ADVARRA INC
PO BOX 74008070
CHICAGO,IL606748070 		31-1358981   170,484 0     MEDICAL FND SUPPORT
(2) ARKANSAS CHILDREN'S RESEARCH INSTITUTE
ONE CHILDRENS WAY FINANCIAL SVCS
SLOT 663
LITTLE ROCK,AR722023591 		71-0694931 509C3 41,065 0     MEDICAL FND SUPPORT
(3) AZENTA LIFE SCIENCES
PO BOX 3865
CAROL STEAM,IL601323865 		20-0628587 501C3 1,334,126 0     MEDICAL FND SUPPORT
(4) BAYLOR COLLEGE OF MEDICINE
ONE BAYLOR PLAZA SUITE 600-D
HOUSTON,TX770303411 		74-1613878 501C3 81,590 0     MEDICAL FND SUPPORT
(5) BOSTON CHILDREN'S HOSPITAL
300 LONGWOOD AVENUE
BOSTON,MA02115 		04-2774441 501C3 316,816 0     MEDICAL FND SUPPORT
(6) BRIGHAM AND WOMEN'S HOSPITAL
BANK OF AMERICA NA PO BOX 3887
BOSTON,MA022413887 		04-2312909 501C3 1,437,026 0     MEDICAL FND SUPPORT
(7) CHILDREN'S HOSPITAL OF PHILADELPHIA
PO BOX 8550 LOCKBOX 1457
PHLILADELPHIA,PA191781457 		23-1352166 501C3 14,635 0     MEDICAL FND SUPPORT
(8) DANA-FARBER CANCER INSTITUTE INC
ATTN RESEARCH ACCOUNTING
BOSTON,MA02215 		04-2263040 501C3 160,790 0     MEDICAL FND SUPPORT
(9) DUKE UNIVERSITY
PO BOX 602651
CHARLOTTE,NC282602651 		56-0532129 501C3 1,767,347 0     MEDICAL FND SUPPORT
(10) EMORY UNIVERSITY
PO BOX 935084
ATLANTA,GA311935084 		58-0566256 501C3 468,542 0     MEDICAL FND SUPPORT
(11) FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
350 COMMUNITY DRIVE
MANHASSET,NY11030 		11-2673595 501C3 344,781 0     MEDICAL FND SUPPORT
(12) FRED HUTCHINSON CANCER CENTER
1100 FAIRVIEW AVE NMAILSTOP J6-330
SEATTLE,WA98109 		91-1935159 501C3 523,050 0     MEDICAL FND SUPPORT
(13) HOSPITAL FOR SPECIAL SURGERY
535 EAST 70TH STREET
NEW YORK,NY10021 		13-1624135 501C3 72,094 0     MEDICAL FND SUPPORT
(14) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
ONE GUSTAVE L LEVY PLACE BOX 3500
NEW YORK,NY100296574 		13-6171197 501C3 2,441,029 0     MEDICAL FND SUPPORT
(15) IHC HEALTH SERVICES INC
36 SOUTH STATE STREET SUITE 2200
SALT LAKE CITY,UT84111 		94-2854057   110,292 0     MEDICAL FND SUPPORT
(16) INDIANA UNIVERSITY
620 UNION DRIVE ROOM 618
INDIANAPOLIS,IN462025167 		35-6001673 501C3 45,095 0     MEDICAL FND SUPPORT
(17) JOHNS HOPKINS UNIVERSITY
12529 COLLECTIONS CENTER DRIVE
CHICAGO,IL60693 		52-0595110 501C3 4,594,301 0     MEDICAL FND SUPPORT
(18) JOSLIN DIABETES CENTER
ONE JOSLIN PLACE
BOSTON,MA022155306 		04-2203836 501C3 18,800 0     MEDICAL FND SUPPORT
(19) LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT H
1124 W CARSON STREET
TORRANCE,CA905022006 		95-2138184 501C3 49,727 0     MEDICAL FND SUPPORT
(20) MASSACHUSETTS GENERAL HOSPITAL
55 FRUIT STREET
BOSTON,MA02114 		04-2697983 501C3 645,781 0     MEDICAL FND SUPPORT
(21) MAYO CLINIC
200 FIRST STREET SOUTHWEST
ROCHESTER,MN55905 		41-6011702 501C3 137,750 0     MEDICAL FND SUPPORT
(22) MAYO CLINIC JACKSONVILLE
4500 SAN PABLO ROAD
JACKSONVILLE,FL32224 		59-3337028 501C3 82,893 0     MEDICAL FND SUPPORT
(23) METROPLEX CLINICAL RESEARCH CENTER
8144 WALNUT HILL LANE SUITE 810
DALLAS,TX75231 		20-8454424   26,190 0     MEDICAL FND SUPPORT
(24) MY OWN MED INC
4825 ESSEX AVENUE
CHEVY CHASE,MD20815 		46-2108432 501C3 47,875 0     MEDICAL FND SUPPORT
(25) NATIONAL JEWISH HEALTH
1400 JACKSON STREET M216
DENVER,CO80206 		74-2044647 501C3 264,894 0     MEDICAL FND SUPPORT
(26) NEW YORK UNIVERSITY-SCHOOL OF MEDICINE
PO BOX 415026
BOSTON,MA022415026 		13-5562308 501C3 748,533 0     MEDICAL FND SUPPORT
(27) NORTHWESTERN UNIVERSITY
633 CLARK ROOM G547
EVANSTON,IL60208 		36-2167817 501C3 27,977 0     MEDICAL FND SUPPORT
(28) OHIO STATE UNIVERSITY
1960 KENNY ROAD
COLUMBUS,OH43210 		31-6025986 501C3 56,912 0     MEDICAL FND SUPPORT
(29) OHSU-PATIENT BUSINESS SVC
PO BOX 3595
PORTLAND,OR97207 		93-1176109 501C3 17,133 0     MEDICAL FND SUPPORT
(30) REGENTS OF THE UNIVERSITY OF CALIFORNIA AT IRVINE
228 ALDRICH HALL
IRVINE,CA926971050 		95-2226406 501C3 35,488 0     MEDICAL FND SUPPORT
(31) REGENTS OF THE UNIVERSITY OF COLORADO
PO BOX 910238
AURORA,CO80045 		84-6000555 501C3 358,841 0     MEDICAL FND SUPPORT
(32) RESEARCH FOUNDATION OF SUNY
35 STATE STREET
ALBANY,NY122072826 		14-1368361 501C3 26,056 0     MEDICAL FND SUPPORT
(33) RHO FEDERAL SYSTEMS DIVISION INC
2635 E NC HWY 54
DURHAM,NC27713 		56-1927659   49,975 0     MEDICAL FND SUPPORT
(34) SANFORD RESEARCH
2301 E 60TH ST
SIOUX FALLS,SD57104 		46-0450378 501C3 15,570 0     MEDICAL FND SUPPORT
(35) SEATTLE CHILDREN'S HOSPITAL RESEARCH INSTITUTE
818 STEWART 3RD FLOOR
SEATTLE,WA981240728 		91-0564748 501C3 366,782 0     MEDICAL FND SUPPORT
(36) STANFORD UNIVERSITY
PO BOX 884253
LOS ANGELES,CA900884253 		94-1156365 501C3 289,711 0     MEDICAL FND SUPPORT
(37) SWEDISH HEALTH SERVICES - GRANTS
SWEDISH HEALTH SERVICES PO BOX
35143 LB 1129
SEATTLE,WA981249845 		91-0433740 501C3 29,647 0     MEDICAL FND SUPPORT
(38) THE CLEVELAND CLINIC FOUNDATION
PO BOX 931562
CLEVELAND,OH44193 		34-0714585 501C3 579,955 0     MEDICAL FND SUPPORT
(39) THE MEDICAL COLLEGE OF WISCONSIN INC
8701 WATERTOWN PLANK RD
MILWAUKEE,WI53226 		39-0806261 501C3 151,602 0     MEDICAL FND SUPPORT
(40) THE REGENTS UNIVERSITY CALIFORNIA SANDIEGO
UCSD CAMPUS MAIN DEPOSITORY PO BOX
741539
LOS ANGELES,CA900741539 		95-6006144 501C3 91,408 0     MEDICAL FND SUPPORT
(41) THE UNIV OF TEXAS SOUTHWESTERN MEDICAL CENTER
LOCK BOX 845477
DALLAS,TX75284 		75-6002868 501C3 194,506 0     MEDICAL FND SUPPORT
(42) TRUSTEES OF COLUMBIA UNIVERSITY
1150 SAINT NICOLAS AVE
NEW YORK,NY10032 		13-5598093 501C3 121,137 0     MEDICAL FND SUPPORT
(43) TUFTS MEDICAL CENTER
800 WASHINGTON STREET
BOSTON,MA02111 		04-3400617 501C3 14,787 0     MEDICAL FND SUPPORT
(44) UNIV OF MINNESOTA REGENTS
NW 5957
MINNEAPOLIS,MN554855957 		41-6007513 501C3 87,246 0     MEDICAL FND SUPPORT
(45) UNIVERSITY OF ALABAMA AT BIRMINGHAM
1720 2ND AVENUE SOUTH
BIRMINGHAM,AL35294 		63-6005396 501C3 25,423 0     MEDICAL FND SUPPORT
(46) UNIVERSITY OF CALIFORNIA LOS ANGELES
757 WESTWOOD PLAZA SUITE 1119
LOS ANGELES,CA900957495 		95-6006143 501C3 8,870 0     MEDICAL FND SUPPORT
(47) UNIVERSITY OF CALIFORNIA SAN FRANCISCO
UCSF MAIN DEPOSITORY PO BOX 748872
LOS ANGELES,CA900744872 		94-6036493 501C3 6,689,549 0     MEDICAL FND SUPPORT
(48) UNIVERSITY OF CALIFORNIA DAVIS
UC DAVIS AR LOCKBOX PO BOX 741816
LOS ANGELES,CA900741816 		94-6036494 501C3 43,036 0     MEDICAL FND SUPPORT
(49) UNIVERSITY OF CINCINNATI
UNIVERSITY HALL SUITE 530
CINCINNATI,OH45221 		31-6000989 501C3 147,882 0     MEDICAL FND SUPPORT
(50) UNIVERSITY OF FLORIDA
2033 MOWRY ROAD 152 CGRC PO BOX
103622
GAINESVILLE,FL32610 		59-6002052 501C3 28,023 0     MEDICAL FND SUPPORT
(51) UNIVERSITY OF IOWA
2 GILMORE HALL
IOWA CITY,IA52242 		42-6004813 501C3 33,666 0     MEDICAL FND SUPPORT
(52) UNIVERSITY OF MARYLAND BALTIMORE
PO BOX 41428
BALTIMORE,MD212036428 		52-6002033 501C3 153,586 0     MEDICAL FND SUPPORT
(53) UNIVERSITY OF MASSACHUSETTS WORCESTER
55 LAKE AVENUE NORTH
WORCESTER,MA016550002 		04-3167352 501C3 88,659 0     MEDICAL FND SUPPORT
(54) UNIVERSITY OF MIAMI
PO BOX 405803
ATLANTA,GA303845803 		59-0624458 501C3 41,559 0     MEDICAL FND SUPPORT
(55) UNIVERSITY OF MICHIGAN
BOX 223131
PITTSBURGH,PA152512131 		38-6006309 501C3 491,608 0     MEDICAL FND SUPPORT
(56) UNIVERSITY OF MISSOURI
118 UNIVERSITY HALL
COLUMBIA,MO65211 		43-6003859 501C3 38,317 0     MEDICAL FND SUPPORT
(57) UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
PO BOX 402420
ATLANTA,GA303842420 		56-6001393 501C3 471,088 0     MEDICAL FND SUPPORT
(58) UNIVERSITY OF PENNSYLVANIA
PO BOX 785541
PHILADELPHIA,PA191785541 		23-1352685 501C3 76,455 0     MEDICAL FND SUPPORT
(59) UNIVERSITY OF PITTSBURGH
ATTN XXX-XX-XXXX ROSS STREET 154-0455
PITTSBURGH,PA152620001 		25-0965591 501C3 523,811 0     MEDICAL FND SUPPORT
(60) UNIVERSITY OF TEXAS MD ANDERSON CANCER CTR
PO BOX 4390 GRANTS CONTRACT ACCTNG
202
HOUSTON,TX772104390 		74-6001118 501C3 40,008 0     MEDICAL FND SUPPORT
(61) UNIVERSITY OF WA GRANTS & CONTRACTS
12455 COLLECTIONS DRIVE
CHICAGO,IL606930001 		91-6001537 501C3 765,378 0     MEDICAL FND SUPPORT
(62) UNIVERSITY OF WISCONSIN MADISON BOARD OF REGENTS
600 HIGHLAND AVE
MADISON,WI53792 		39-6006492 501C3 127,804 0     MEDICAL FND SUPPORT
(63) VANDERBILT UNIVERSITY MED CTR
PO BOX 121236
DALLAS,TX753121236 		62-0476822 501C3 145,600 0     MEDICAL FND SUPPORT
(64) VIRGINIA COMMONWEALTH UNIVERSITY
GRANTS AND CONTRACTS ACCOUNTING BOX
843039
RICHMOND,VA23284 		54-6001758 501C3 173,539 0     MEDICAL FND SUPPORT
(65) WASHINGTON UNIVERSITY IN ST LOUIS
7425 FORSYTHE
ST LOUIS,MO63105 		46-0653611 501C3 550,626 0     MEDICAL FND SUPPORT
(66) YALE UNIVERSITY
PO BOX 1873
NEW HAVEN,CT065081873 		06-0646973 501C3 183,605 0     MEDICAL FND SUPPORT
2
Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ................. Bullet Image
61
3
Enter total number of other organizations listed in the line 1 table ........................ . Bullet Image
5
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50055P
Schedule I (Form 990) 2022

Schedule I (Form 990) 2022
Page 2
Part III
Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Number of
recipients		 (c) Amount of
cash grant		 (d) Amount of
noncash assistance		 (e) Method of valuation (book,
FMV, appraisal, other)		 (f) Description of noncash assistance
(1)
(2)
(3)
(4)
(5)
(6)
(7)
Part IV
Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.
Return Reference Explanation
PART I, LINE 2: SUB-RECIPIENT MONITORING POLICY -MEDICAL RESEARCH SUB AWARD BRI HAS FORMAL POLICIES AND PRODECURES TO ASSURE FULL COMPLIANCE WITH APPLICABLE POLICIES AND LAWS GOVERNING FEDERAL GRANTS. THE SUB-RECIPIENT MONITORING POLICY PROVIDES ASSURANCE THAT SUB-RECIPIENTS COMPLY WITH FEDERAL GRANT REGULATIONS. THIS POLICY SETS THE CRITERIA TO ESTABLISH ELIGIBILITY OF SUB-RECIPIENTS TO PROVIDE ANNUAL AUDITED FINANCIAL REPORTS AND THE ANNUAL OMB SINGLE AUDIT REPORT THAT IDENTIFY COMPLIANCE WITH FEDERAL LAWS AND REGULATIONS. THE REPORTS ARE ANALYZED WITH EMPHASIS ON AUDITOR'S ASSESSMENT OF SUB-RECIPIENT INTERNAL CONTROLS AND A STANDARDIZED RISK ASSESSMENT IS PRESENTED TO MANAGEMENT ON EACH SUB-RECIPIENT. A MANAGEMENT LETTER IS ISSUED TO EACH SUB-RECIPIENT SHOWING ANY FINDINGS ON THEIR OMB SINGLE AUDIT REPORT, AND MEASUREMENTS ARE SET FOR INCREASED MONITORING WHEN AN ELEVATED LEVEL OF RISK IS ESTABLISHED. MANAGEMENT HAS COMMUICATED WITH AN EDUCATED ADMINISTRATIVE STAFF REGARDING IMPLEMENTATION OF THIS POLICY. THE DIRECTOR OF GRANTS AND CONTRACTS IS RESPONSIBILE FOR MONITORING SUB-RECIPIENT ADHERENCE TO FINANCIAL REGULATIONS. THE PRINCIPAL INVESTIGATOR IS RESPONSIBLE FOR OVERSEEING THE SATISFACTORY PERFORMANCE OF THE SUB-AWARD TO ENSURE THAT GOALS ARE ACHIEVED. IF THERE ARE UNUSUAL OR UNFORESEEN ITEMS, THESE WILL BE INVESTIGATED.
Schedule I (Form 990) 2022



Additional Data


Software ID:  
Software Version:  


Schedule J
(Form 990)
Department of the Treasury
Internal Revenue Service
Compensation Information
For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
SchJMediumBullet Complete if the organization answered "Yes" on Form 990, Part IV, line 23.
SchJMediumBullet Attach to Form 990.
SchJMediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2022
Open to Public Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I
Questions Regarding Compensation
Yes
No
1a
Check the appropiate box(es) if the organization provided any of the following to or for a person listed on Form
990, Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
b
If any of the boxes on Line 1a are checked, did the organization follow a written policy regarding payment or reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain .....
1b
 
 
2
Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all
directors, trustees, officers, including the CEO/Executive Director, regarding the items checked on Line 1a? ....
2
 
 
3
Indicate which, if any, of the following the filing organization used to establish the compensation of the
organization's CEO/Executive Director. Check all that apply. Do not check any boxes for methods
used by a related organization to establish compensation of the CEO/Executive Director, but explain in Part III.
4
During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing organization or a related organization:
a
Receive a severance payment or change-of-control payment? .............
4a
 
No
b
Participate in, or receive payment from, a supplemental nonqualified retirement plan? .........
4b
Yes
 
c
Participate in, or receive payment from, an equity-based compensation arrangement? .........
4c
 
No
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.
5
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the revenues of:
a
The organization? ....................
5a
 
No
b
Any related organization? .......................
5b
 
No
If "Yes," on line 5a or 5b, describe in Part III.
6
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any
compensation contingent on the net earnings of:
a
The organization? ..................
6a
 
No
b
Any related organization? ......................
6b
 
No
If "Yes," on line 6a or 6b, describe in Part III.
7
For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed
payments not described in lines 5 and 6? If "Yes," describe in Part III ............
7
 
No
8
Were any amounts reported on Form 990, Part VII, paid or accured pursuant to a contract that was
subject to the initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe
in Part III ..........................
8
 
No
9
If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in Regulations section 53.4958-6(c)? .........................
9
 
 
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50053T
Schedule J (Form 990) 2022

Schedule J (Form 990) 2022
Page 2
Part II
Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the
instructions, on row (ii). Do not list any individuals that are not listed on Form 990, Part VII.
Note. The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(A) Name and Title (B) Breakdown of W-2, 1099-MISC compensation, and/or 1099-NEC (C) Retirement and other deferred compensation (D) Nontaxable
benefits		 (E) Total of columns
(B)(i)-(D) 		(F) Compensation in column (B) reported as deferred on prior Form 990
(i) Base
compensation 		(ii) Bonus & incentive
compensation 		(iii) Other reportable compensation
1KETUL PATEL
CHIEF EXECUTIVE OFFICER VMFH 		(i)

(ii)		 1,348,212
-------------
0 		1,189,554
-------------
0 		530,202
-------------
0 		17,750
-------------
0 		11,786
-------------
0 		3,097,504
-------------
0 		192,482
-------------
0
2JANE BUCKNER MD
PRESIDENT 		(i)

(ii)		 480,808
-------------
0 		62,010
-------------
0 		0
-------------
0 		27,000
-------------
0 		1,212
-------------
0 		571,030
-------------
0 		0
-------------
0
3MARGARET MCCORMICK PHD
EXECUTIVE DIRECTOR & COO 		(i)

(ii)		 271,356
-------------
0 		19,948
-------------
0 		0
-------------
0 		27,000
-------------
0 		4,548
-------------
0 		322,852
-------------
0 		0
-------------
0
4WILLIAM KWOK PHD
RESEARCH MEMBER 		(i)

(ii)		 274,893
-------------
0 		400
-------------
0 		0
-------------
0 		27,000
-------------
0 		3,612
-------------
0 		305,905
-------------
0 		0
-------------
0
5STEVEN ZIEGLER PHD
DIRECTOR, ACADEMIC AFFAIRS 		(i)

(ii)		 265,310
-------------
0 		400
-------------
0 		0
-------------
0 		20,111
-------------
0 		5,124
-------------
0 		290,945
-------------
0 		0
-------------
0
6MICHAEL LABOSIER
CFO 		(i)

(ii)		 221,874
-------------
0 		400
-------------
0 		0
-------------
0 		27,000
-------------
0 		6,674
-------------
0 		255,948
-------------
0 		0
-------------
0
7DANIEL CAMPBELL PHD
DIRECTOR, CENTER FOR FUNDAMENTAL IMM 		(i)

(ii)		 220,149
-------------
0 		1,800
-------------
0 		0
-------------
0 		14,634
-------------
0 		5,400
-------------
0 		241,983
-------------
0 		0
-------------
0
8CARMEN MIKACENIC MD
ASSOCIATE RESEARCH MEMBER 		(i)

(ii)		 216,514
-------------
0 		400
-------------
0 		0
-------------
0 		20,500
-------------
0 		7,248
-------------
0 		244,662
-------------
0 		0
-------------
0
9JAMES LORD
RESEARCH ASSISTANT MEMBER 		(i)

(ii)		 213,444
-------------
0 		400
-------------
0 		0
-------------
0 		19,500
-------------
0 		4,728
-------------
0 		238,072
-------------
0 		0
-------------
0
Schedule J (Form 990) 2022

Schedule J (Form 990) 2022
Page 3
Part III
Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.
Return Reference Explanation
PART I, LINE 3 DURING THE CALENDAR YEAR 2022, COMPENSATION FOR THE TOP MANAGEMENT OFFICIAL WAS ESTABLISHED BY COMMONSPIRIT HEALTH. COMMONSPIRIT HEALTH USED THE FOLLOWING TO ESTABLISH THE TOP MANAGEMENT OFFICIAL'S COMPENSATION: (1) COMPENSATION COMMITTEE; (2) INDEPENDENT COMPENSATION CONSULTANT; (3) COMPENSATION SURVEY OR STUDY; (4) APPROVAL BY THE BOARD OR COMPENSATION COMMITTEE.
PART I, LINE 4B CERTAIN REPORTABLE INDIVIDUALS ARE COVERED BY AN EXECUTIVE SEVERANCE POLICY THAT PROVIDES MARKET-STANDARD COMPENSATION, RANGING FROM PAYMENTS OF 9 MONTHS TO 2 YEARS OF BASE COMPENSATION, DEPENDING ON THE EXECUTIVE'S POSITION, IN THE EVENT OF A POSITION ELIMINATION OR OTHER INVOLUNTARY TERMINATION, IN ACCORDANCE WITH THE GUIDELINES OF THE POLICY. DURING THE 2022 CALENDAR YEAR, COMMONSPIRIT HEALTH ("COMMONSPIRIT") MAINTAINED A SUPPLEMENTAL NON-QUALIFIED DEFERRED COMPENSATION PLAN FOR DIVISION CEOS/PRESIDENTS AND OTHER DESIGNATED COMMONSPIRIT EXECUTIVES AT THE LEVEL OF SENIOR VICE PRESIDENT AND ABOVE. DURING 2022 THE FOLLOWING DISTRIBUTIONS WERE MADE BY COMMONSPIRIT FROM THE DEFERRED COMPENSATION PLAN: KETUL J PATEL, $303,924. DUE TO THE "SUPER" VESTING RULES UNDER COMMONSPIRIT'S DEFERRED COMPENSATION PLAN, PARTICIPANTS WHO HAVE MET CERTAIN REQUIREMENTS SUCH AS INVOLUNTARY TERMINATION WITHOUT CAUSE, AGE, AGE AND YEARS OF SERVICE, OR MORE THAN 5 YEARS OF PLAN PARTICIPATION ARE ELIGIBLE TO RECEIVE THEIR 2022 CONTRIBUTIONS IN CASH. THESE CASH PAYOUTS ARE INCLUDED IN THE PARTICIPANT'S REPORTABLE COMPENSATION IN COLUMN (III) OTHER REPORTABLE COMPENSATION ON SCHEDULE J PART II. DURING 2022, THE FOLLOWING PAYMENTS WERE MADE PURSUANT TO THE SUPER VESTING RULES: KETUL J PATEL, $212,946.
SCHEDULE J, PART II: BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON FOLLOWS COMMONSPIRIT'S EXECUTIVE COMPENSATION PHILOSOPHY. COMMONSPIRIT'S EXECUTIVE COMPENSATION PHILOSOPHY IS DESIGNED TO ASSIST COMMONSPIRIT IN ATTRACTING AND RETAINING THE CALIBER OF EXECUTIVES REQUIRED TO ENABLE COMMONSPIRIT TO FULFILL ITS MISSION OF PROVIDING HIGH QUALITY HEALTHCARE FOR ALL PERSONS REGARDLESS OF THEIR ABILITY TO PAY FOR SERVICES, IMPROVING THE QUALITY OF LIFE IN THE COMMUNITIES COMMONSPIRIT SERVES, PROMOTING PATIENT AND EMPLOYEE SATISFACTION, AND ENSURING FINANCIAL STABILITY. A SUBSTANTIAL PORTION OF EXECUTIVE COMPENSATION IS PERFORMANCE BASED AND IS LINKED TO ORGANIZATIONAL GOALS APPROVED IN ADVANCE BY THE HUMAN RESOURCES AND COMPENSATION COMMITTEE. THESE GOALS INCLUDE ATTAINMENT OF ANNUAL AND LONG-TERM FINANCIAL PERFORMANCE, CERTAIN HEALTHCARE QUALITY STANDARDS AND COMMONSPIRIT'S COMMITMENT TO SERVING THE POOR AND DISENFRANCHISED IN THE COMMUNITIES IT SERVES. TOTAL COMPENSATION, WHICH INCLUDES BASE SALARY, ANNUAL, AND LONG-TERM INCENTIVE COMPENSATION, IS ESTABLISHED TO APPROXIMATE THE PREVAILING MARKET CONDITIONS FOR EXECUTIVES OF COMPANIES OF SIMILAR SIZE, REVENUES AND COMPLEXITY. PAYMENTS PURSUANT TO A LONG-TERM FINANCIAL PERFORMANCE GOAL WERE PAID IN CALENDAR YEAR 2022. KETUL PATEL WAS COMPENSATED BY COMMONSPIRIT HEALTH FOR HIS SERVICES TO BENAROYA RESEARCH INSTITUTE. FOR 990 PURPOSES, COMMONSPIRIT HEALTH IS AN UNRELATED ORGANIZATION, SO COMPENSATION HAS BEEN PRESENTED AS PAID BY BENAROYA RESEARCH INSTITUTE.
Schedule J (Form 990) 2022

Additional Data


Software ID:  
Software Version:  

Note: To capture the full content of this document, please select landscape mode (11" x 8.5") when printing.

Schedule K
(Form 990)
Department of the Treasury
Internal Revenue Service
Supplemental Information on Tax-Exempt Bonds
SchKMediumBullet Complete if the organization answered "Yes" to Form 990, Part Ⅵ, line 24a. Provide descriptions,
explanations, and any additional information in Part Ⅵ.
SchKMediumBullet Attach to Form 990.
SchKMediumBulletGo to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public
Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number
91-0653422
Part Ⅰ
Bond Issues
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On
behalf of
issuer		 (i) Pool
financing
Yes No Yes No Yes No
A WA ECON DEVEL FIN AUTH-2019 SERIES A
  		91-1493002 000000000 02-26-2019 25,716,490 SEE PART VI   X X     X
B WA ECON DEVEL FIN AUTH-2019 SERIES B
  		91-1493002 000000000 02-26-2019 6,000,000 SEE PART VI   X X     X
Part Ⅱ
Proceeds
A B C D
1 Amount of bonds retired .................. 2,881,683 297,627    
2 Amount of bonds legally defeased ..............        
3 Total proceeds of issue .................. 25,716,490 6,000,000    
4 Gross proceeds in reserve funds .............        
5 Capitalized interest from proceeds .............        
6 Proceeds in refunding escrows ...............        
7 Issuance costs from proceeds ...............        
8 Credit enhancement from proceeds .............        
9 Working capital expenditures from proceeds .............        
10 Capital expenditures from proceeds .............   6,000,000    
11 Other spent proceeds ............. 25,716,490      
12 Other unspent proceeds .............        
13 Year of substantial completion ............. 2023
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a current refunding issue of tax-exempt
bonds (or, if issued prior to 2020, a current refunding issue)? ........ 		X   X          
15 Were the bonds issued as part of an advance refunding issue of taxable
bonds (or, if issued prior to 2020, an advance refunding issue)? ........ 		  X   X        
16 Has the final allocation of proceeds been made? .......... X   X          
17 Does the organization maintain adequate books and records to support the final allocation of proceeds? .................. X   X          
For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50193E
Schedule K (Form 990) 2021

Schedule K (Form 990) 2021
Page 2
Part Ⅲ
Private Business Use
A B C D
Yes No Yes No Yes No Yes No
1 Was the organization a partner in a partnership, or a member of an LLC, which owned property financed by tax-exempt bonds? .............   X   X        
2 Are there any lease arrangements that may result in private business use of bond-financed property? ...............   X   X        
3a Are there any management or service contracts that may result in private business use of bond-financed property? .............   X   X        
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside counsel to review any management or service contracts relating to the financed property?                
c Are there any research agreements that may result in private business use of bond-financed property? ............. X   X          
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other outside counsel to review any research agreements relating to the financed property? X   X          
4 Enter the percentage of financed property used in a private business use by entities other than a section 501(c)(3) organization or a state or local government ....SchKMediumBullet 3.840 % 3.840 %    
5 Enter the percentage of financed property used in a private business use as a result of unrelated trade or business activity carried on by your organization, another section 501(c)(3) organization, or a state or local government ......... SchKMediumBullet        
6 Total of lines 4 and 5 ............. 3.840 % 3.840 %    
7 Does the bond issue meet the private security or payment test? ...   X   X        
8a Has there been a sale or disposition of any of the bond-financed property to a nongovernmental person other than a 501(c)(3) organization since the bonds were issued?.............   X   X        
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or disposed of. ..        
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations sections 1.141-12 and 1.145-2? .............                
9 Has the organization established written procedures to ensure that all nonqualified bonds of the issue are remediated in accordance with the requirements under
Regulations sections 1.141-12 and 1.145-2? ........ 		X   X          
Part Ⅳ
Arbitrage
A B C D
Yes No Yes No Yes No Yes No
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Penalty in Lieu of Arbitrage Rebate? ...   X   X        
2 If "No" to line 1, did the following apply? ....
a Rebate not due yet? ....... X   X          
b Exception to rebate? ........   X   X        
c No rebate due? .........   X   X        
If "Yes" to line 2c, provide in Part Ⅵ the date the rebate
computation was performed ......
3 Is the bond issue a variable rate issue? ..... X   X          
Schedule K (Form 990) 2021

Schedule K (Form 990) 2021
Page 3
Part Ⅳ
Arbitrage (Continued)
A B C D
Yes No Yes No Yes No Yes No
4a Has the organization or the governmental issuer entered into a qualified hedge with respect to the bond issue?   X   X        
b Name of provider ..........  
  		 
  		 
  		 
 
c Term of hedge .........        
d Was the hedge superintegrated? ......                
e Was the hedge terminated? ........                
5a Were gross proceeds invested in a guaranteed investment contract (GIC)?   X   X        
b Name of provider ..........  
  		 
  		 
  		 
 
c Term of GIC .........        
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied? ........                
6 Were any gross proceeds invested beyond an available temporary period?   X   X        
7 Has the organization established written procedures to monitor the requirements of section 148? ... X   X          
Part Ⅴ
Procedures To Undertake Corrective Action
--------------------------------------------------------------------------------------------------------------- A B C D
Yes No Yes No Yes No Yes No
Has the organization established written procedures to ensure that violations of federal tax requirements are timely identified and corrected through the voluntary closing agreement program if self-remediation is not available under applicable regulations? X   X          
Part Ⅵ
Supplemental Information. Provide additional information for responses to questions on Schedule K. (See instructions).
Return Reference Explanation
PART 1, LINE A, COLUMN F PURPOSES: TO REFUND WEDFA SERIES 2012 B BONDS ISSUED 06/01/2012, AND WEDFA SERIES 2016 BONDS ISSUED ON 06/01/2016.
PART 1, LINE B, COLUMN F PURPOSES: TO FUND RESEARCH FACILITY IMPROVEMENTS AND EQUIPMENT PURCHASES ON A DRAW-DOWN BASIS OVER A THREE-YEAR PERIOD ENDING IN 2022.
Schedule K (Form 990) 2021

Additional Data


Software ID:  
Software Version:  

SCHEDULE O
(Form 990)

Department of the Treasury
Internal Revenue Service
Supplemental Information to Form 990 or 990-EZ

Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
MediumBullet Attach to Form 990 or 990-EZ.
MediumBullet Go to www.irs.gov/Form990 for the latest information.
OMB No. 1545-0047
2021
Open to Public
Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Return Reference Explanation
FORM 990, PART III, LINE 4: AT BRI, WE INTEGRATE THREE TYPES OF MEDICAL RESEARCH - LABORATORY RESEARCH, TRANSLATIONAL RESEARCH, AND CLINICAL RESEARCH - TO IMPROVE LIVES. ALL OUR SCIENTISTS COLLABORATE TO EXPLORE BASIC SCIENCE AS WELL AS CLINICAL APPLICATIONS, WHICH WE BELIEVE IS THE BEST WAY TO DESIGN STUDIES WITH THE HIGHEST POTENTIAL FOR SUCCESS. AT BRI, DISCOVERY STARTS IN THE LABORATORY BUT IS SPARKED BY THE NEEDS AND EXPERIENCES OF PATIENTS.
FORM 990, PART III, LINE 1: BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON (BRI) IS ONE OF THE FEW RESEARCH INSTITUTES IN THE WORLD DEVOTED TO FINDING CAUSES AND CURES FOR AUTOIMMUNE AND IMMUNE SYSTEM DISEASES, INCLUDING TYPE 1 DIABETES, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS, LUPUS, INFLAMMATORY BOWEL DISEASE, CANCERS, ALLERGIES AND INFECTIOUS DISEASES. BRI IS AFFILIATED WITH VIRGINIA MASON FRANCISCAN HEALTH, WHICH PROVIDES GOVERNANCE AND OVERSIGHT, AND THE VIRGINIA MASON FOUNDATION, WHICH PROVIDES DEVELOPMENT SUPPORT. BRI'S BOLD MISSION IS TO ADVANCE THE SCIENCE TO PREDICT, PREVENT, REVERSE AND CURE DISEASES OF THE IMMUNE SYSTEM TO ACHIEVE OUR VISION OF A HEALTHY IMMUNE SYSTEM FOR EVERYONE. BRI IS LED BY PRESIDENT JANE H. BUCKNER, MD, AND EXECUTIVE DIRECTOR/COO MARGARET MCCORMICK, PHD. DISCOVERIES AT BRI ARE ACCELERATED BY OUR TALENTED RESEARCHERS, COLLABORATIVE CULTURE AND APPLICATION OF NEW TECHNOLOGIES AND DATA ANALYTICS IN A QUEST TO UNDERSTAND WHAT CAN CAUSE THE IMMUNE SYSTEM TO FALL OUT OF BALANCE AND HOW TO RESTORE IT TO HEALTH. TO THAT END, OUR SCIENTIFIC ACTIVITIES ARE ORGANIZED INTO FOUR CENTERS OF DISCOVERY TO FACILITATE KNOWLEDGE SHARING AND FOR CENTERS AND CORE LABS TO BUILD ON DISCOVERIES FROM INDIVIDUAL LABS: - INTERVENTIONAL IMMUNOLOGY, DIRECTED BY CARLA GREENBAUM, MD - TRANSLATIONAL IMMUNOLOGY, DIRECTED BY KAREN CEROSALETTI, PHD - FUNDAMENTAL IMMUNOLOGY, DIRECTED BY DANIEL CAMPBELL, PHD - SYSTEMS IMMUNOLOGY, DIRECTED BY ADAM LACY-HULBERT, PHD THE CENTER FOR INTERVENTIONAL IMMUNOLOGY (CII) USES SMALL AND LARGE-SCALE CLINICAL STUDIES TO TRANSLATE LAB DISCOVERIES TO PATIENT THERAPIES. CII STUDIES ENCOMPASS ALL PHASES OF CLINICAL RESEARCH, FROM BRI'S BIOREPOSITORIES, WHICH ENROLL INDIVIDUALS WITH AND WITHOUT IMMUNE SYSTEM DISEASES, TO MULTI-CENTER CLINICAL TRIALS OF DISEASE-MODIFYING THERAPIES. INVESTIGATOR-INITIATED STUDIES OF SHORT-COURSE IMMUNOTHERAPY OR VACCINES SHOW HOW PERTURBING THE IMMUNE SYSTEM CAN REVEAL THE DIFFERENTIAL FUNCTIONS OF THE IMMUNE SYSTEM IMPACTED BY DISEASE. THE IMMUNE TOLERANCE NETWORK, A GLOBAL CONSORTIUM FOCUSED ON CONDUCTING CLINICAL TRIALS TO PROMOTE TOLERANCE IN AUTOIMMUNITY, ORGAN TRANSPLANT AND ALLERGY/ASTHMA IS PART OF THIS CENTER. THE CENTER FOR TRANSLATIONAL IMMUNOLOGY (CTI) INVOLVES STUDYING BLOOD AND TISSUE SAMPLES FROM PEOPLE WITH IMMUNE SYSTEM DISEASES INCLUDING AUTOIMMUNE DISEASES, ALLERGIES, INFECTIOUS DISEASES AND CANCER. CTI USES ADVANCED SYSTEMS IMMUNOLOGY TOOLS TO EXAMINE GENES, CELLS AND MOLECULES INVOLVED IN THESE DISEASES. ITS STUDIES AIM TO DISCOVER HOW DISEASES START AND PROGRESS; IDENTIFY BIOLOGICAL CHARACTERISTICS TIED TO CERTAIN DISEASES OR RESPONSE TO THERAPY; AND TO FIND NEW DRUG TARGETS. THE BRI BIOREPOSITORY IS A COLLECTION OF BLOOD, SERUM AND TISSUE SAMPLES AND MEDICAL HISTORIES FROM VOLUNTEERS WITH AND WITHOUT DISEASE. BRI SCIENTISTS AND PHYSICIAN COLLABORATORS WORK TOGETHER TO STUDY TISSUE, BLOOD AND SERUM SAMPLES ALONG WITH THE MEDICAL AND DEMOGRAPHIC DATA. BRI'S BIOREPOSITORY SAMPLES DATE BACK TO 2000 AND INCLUDE MULTIPLE DISEASE CATEGORIES AND A BIOREPOSITORY OF HEALTHY PEOPLE FOR PURPOSES OF COMPARISON. THE CENTER FOR FUNDAMENTAL IMMUNOLOGY (CFI) INVESTIGATES THE IMMUNE SYSTEM TO UNDERSTAND HOW IT WORKS IN HEALTH AND DISEASE. INVESTIGATORS IN THE CFI LOOK AT THE CELLULAR AND MOLECULAR PATHWAYS THAT CONTROL THE IMMUNE SYSTEM, FOCUSING ON GENES, CELLS AND MOLECULES TO BUILD COMPLEX MODELS OF AUTOIMMUNE AND INFLAMMATORY DISEASES TO STUDY THEM IN PRECISE DETAIL. THE CENTER FOR SYSTEMS IMMUNOLOGY (CSI) USES THE LATEST TOOLS TO COLLECT, PROCESS AND EXAMINE DATA FROM STUDIES ACROSS BRI AND AROUND THE WORLD. CSI SELECTS AND IMPLEMENTS NEW TECHNOLOGIES AND DEVELOPS APPROACHES TO ORGANIZE AND ANALYZE LARGE DATA SETS. ITS GOAL IS TO MAKE NEW INSIGHTS ABOUT THE IMMUNE SYSTEM AND THE DISEASES THAT AFFECT IT. EXTERNAL AND ACADEMIC AFFAIRS AT BRI WE BUILD THE NEXT GENERATION OF LEADERS IN IMMUNOLOGY BY WORKING ACROSS OUR CENTERS WITH INTERNS, GRADUATE STUDENTS AND POSTDOCS. WE ALSO TEAM UP WITH OTHER RESEARCH INSTITUTES AND INDUSTRY PARTNERS TO TACKLE NEW RESEARCH QUESTIONS AND ACCELERATE DISCOVERIES. JESSICA HAMERMAN, PHD, IS OUR DIRECTOR FOR ACADEMIC AFFAIRS AND STEVEN ZIEGLER, PHD IS OUR DIRECTOR OF EXTERNAL COLLABORATION. IN DECEMBER 2022, WASHINGTON RESEARCH FOUNDATION ANNOUNCED ITS SIXTH ANNUAL COHORT OF POSTDOCTORAL FELLOWS, TO BE SUPPORTED BY WRF FOR THREE YEARS. AMONG THEM IS BRI'S SHEENAM VERMA, PHD, WHO EARNED A DOCTORATE IN STRUCTURAL BIOLOGY FROM THE REGIONAL CENTRE FOR BIOTECHNOLOGY IN INDIA. IN HER FELLOWSHIP SHE WILL STUDY HOW AUTOANTIBODIES THAT TARGET MICROBIOTA ANTIGENS MIGHT CONTRIBUTE TO AUTOIMMUNITY, WITH THE GOAL OF IDENTIFYING NOVEL BIOMARKER CANDIDATES FOR DIAGNOSIS OF AUTOIMMUNE DISORDERS. BRI HOSTED VIRTUAL SEMINARS FOR WASHINGTON STATE OPPORTUNITY SCHOLARSHIP (WSOS) STEM, CAREER AND TECHNICAL SCHOLARS TO INTRODUCE THEM TO OUR INSTITUTE, WHAT WE DO AND HOW STAFF AND RESEARCHERS WORK TOGETHER TO ADVANCE SCIENCE THAT WILL PREDICT, PREVENT, REVERSE AND CURE DISEASES OF THE IMMUNE SYSTEM. BRI STAFF ALSO TOOK PART IN OPPORTUNITIES SUCH AS A BLACK MENTORS IN MEDICINE PANEL FOR HIGH SCHOOL STUDENTS IN A SEATTLE PUBLIC SCHOOL PROGRAM, WHOLE, AND A BLACK HISTORY MONTH EVENT AT WHY NOT YOU ACADEMY (WNYA), A PUBLIC HIGH SCHOOL CO-FOUNDED BY RUSSELL AND CIARA WILSON IN WHICH STUDENTS LEARNED IN AN IDENTITY-AFFIRMING SCHOOL CULTURE WITH RELEVANT AND CULTURALLY RESPONSIVE PROJECTS.
FORM 990, PART III, LINE 4A (CONTINUED) CONTINUED BLOCKING ASTHMA AND ALLERGIES IN PEOPLE AT RISK MATT ALTMAN, MD, MPHIL, WHO CONDUCTS ASTHMA RESEARCH AT BRI AND TREATS ASTHMA PATIENTS AT UW MEDICINE, WAS SENIOR AUTHOR OF A STUDY THAT IDENTIFIED A POTENTIALLY PROMISING NEW ASTHMA TREATMENT FOR URBAN KIDS AT RISK FOR THE DISEASE. THE STUDY FROM THE INNER-CITY ASTHMA CONSORTIUM (ICAC) FOUND THAT A THERAPY CALLED MEPOLIZUMAB CAN REDUCE ASTHMA ATTACKS AMONG CHILDREN IN LOW-INCOME HISPANIC AND BLACK COMMUNITIES. MEPOLIZUMAB WORKS BY BLOCKING A PROTEIN NECESSARY FOR THE DEVELOPMENT OF EOSINOPHIL, A TYPE OF WHITE BLOOD CELL. THE LAB OF ERIK WAMBRE, PHD, IDENTIFIES AND CHARACTERIZES RARE ANTIGEN-SPECIFIC T CELL RESPONSES TO GAIN INSIGHTS INTO HOW TO TREAT ALLERGIES AND OTHER DISEASES OF THE IMMUNE SYSTEM. IN A STUDY TO DEVELOP MORE EFFECTIVE THERAPIES FOR PEOPLE WITH PEANUT ALLERGIES, THE TEAM DEFINED KEY CORRELATIONS WITH THE REDUCTION OF CLINICAL REACTIVITY TO PEANUTS OBSERVED IN PEANUT-ALLERGIC INDIVIDUALS TREATED WITH PNOIT, THE ONLY KNOWN DISEASE-MODIFYING TREATMENT FOR PEANUT ALLERGY. THEY SHOWED THAT SKEWING ALLERGEN-SPECIFIC T CELLS AWAY FROM THE PATHOGENIC TH2A RESPONSES REPRESENTED A KEY EVENT IN THE DESENSITIZATION TO PEANUTS. TARGETING SOLID TUMORS AND PEDIATRIC BLOOD CANCERS STEVE ZIEGLER, PHD, KAZUSHIGE NINOMIYA, PHD AND TEAM FOUND THAT A SPECIFIC CYTOKINE COULD SERVE AS A BIOMARKER HERALDING THE DEVELOPMENT OF COLON CANCER, AND HOLDS PROMISE AS A THERAPEUTIC TARGET TO FIGHT COLORECTAL CANCERS. IN THE STUDY, THE TEAM FOUND THEY COULD INHIBIT COLORECTAL TUMORS BY BLOCKING TSLP, WHICH SUGGESTS THAT THE CYTOKINE MAY CONTROL THE PROGRESSION OF THE CANCER THROUGH THE REGULATION OF T CELL FUNCTION. HAMID BOLOURI, PHD LED A STUDY WHERE BRI RESEARCHERS AND CHILDREN'S ONCOLOGY GROUP COLLABORATORS USED RNA SEQUENCE DATA TO UNDERSTAND THE ASSOCIATION BETWEEN INFLAMMATORY CYTOKINES AND POOR OUTCOMES OF PEDIATRIC ACUTE MYELOID LEUKEMIA (PAML). TREATMENT WITH JAK/STAT PATHWAY INHIBITORS OR ANTIBODIES THAT NEUTRALIZE IL-6 HAS ALREADY SHOWN PROMISE IN ADULT CASES. UNDERSTANDING THE ROLE OF IL-6 SIGNALING IN PEDIATRIC CASES - AND THE ASSOCIATION OF IL-6 WITH THE PEDIATRIC PAML SUBTYPES WITH POOR CLINICAL OUTCOMES - AIDS THE DEVELOPMENT OF THERAPIES FOR CHILDREN WITH AML.
FORM 990, PART VI, SECTION A, LINE 1A THE GOVERNING BODY DELEGATES TO AN EXECUTIVE COMMITTEE COMPRISED OF FOUR OFFICERS OF THE BOARD AND THE CHAIRS OF EACH STANDING BOARD COMMITTEE, THE AUTHORITY OF THE BOARD OF DIRECTORS IN THE MANAGEMENT OF THE CORPORATION AS MAY BE DEEMED BY THE EXECUTIVE COMMITTEE TO BE APPROPRIATE, TO BE EXERCISED IN TIME PERIODS BETWEEN REGULARLY SCHEDULED MEETINGS OF THE BOARD OF DIRECTORS; PROVIDED THAT THE EXECUTIVE COMMITTEE HAS THE AUTHORITY TO ACT ONLY IN TIME SENSITIVE OR EMERGENCY SITUATIONS. THE DIRECTOR AND THE EXECUTIVE DIRECTOR OF THE CORPORATION SERVE AS EX OFFICIO MEMBERS OF THE EXECUTIVE COMMITTEE WITHOUT VOTING RIGHTS. THE EXECUTIVE COMMITTEE DOES NOT HAVE THE AUTHORITY TO AMEND, ALTER OR REPEAL THE BYLAWS; ELECT, APPOINT OR REMOVE ANY MEMBER OF SUCH EXECUTIVE COMMITTEE OR ANY DIRECTOR OR OFFICER OF THE CORPORATION; AMEND THE ARTICLES OF INCORPORATION; ADOPT A PLAN OF MERGER OR ADOPT A PLAN OF CONSOLIDATION WITH ANOTHER CORPORATION; AUTHORIZE THE SALE, LEASE OR EXCHANGE OF ALL OR SUBSTANTIALLY ALL THE PROPERTY AND ASSETS OF THE CORPORATION NOT IN THE ORDINARY COURSE OF BUSINESS; AUTHORIZE THE VOLUNTARY DISSOLUTION OF THE CORPORATION OR REVOKE PROCEEDINGS THEREFORE; ADOPT A PLAN FOR THE DISTRIBUTION OF THE ASSETS OF THE CORPORATION; OR AMEND, ALTER OR REPEAL ANY RESOLUTION OF THE BOARD WHICH BY ITS TERMS PROVIDES THAT IT SHALL NOT BE AMENDED, ALTERED OR REPEALED BY SUCH EXECUTIVE COMMITTEE. THE EXECUTIVE COMMITTEE ALSO SERVES AS THE PLANNING COMMITTEE FOR THE BOARD OF DIRECTORS AND OVERSEES ANY COMPLIANCE ISSUES RAISED BY THE BOARD OF DIRECTORS.
FORM 990, PART VI, SECTION A, LINE 6 ACCORDING TO THE BYLAWS OF BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON THE ENTITY'S SOLE MEMBER IS VIRGINIA MASON FRANCISCAN HEALTH, A WASHINGTON NONPROFIT CORPORATION.
FORM 990, PART VI, SECTION A, LINE 7A VIRGINIA MASON FRANCISCAN HEALTH ("VMFH") IS THE SOLE CORPORATE MEMBER OF BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON ("BRI"). ACCORDING TO THE ORGANIZATION'S BYLAWS, DIRECTORS SHALL BE APPOINTED OR REFUSED BY THE CORPORATE MEMBER. THE CORPORATE MEMBER MAY APPOINT ONE OR MORE INDIVIDUALS TO THE BOARD OF DIRECTORS, AND MAY AT ANY TIME REMOVE, WITH OR WITHOUT CAUSE, ANY MEMBER OF THE BOARD OF DIRECTORS.
FORM 990, PART VI, SECTION A, LINE 7B VIRGINIA MASON FRANCISCAN HEALTH ("VMFH") IS THE SOLE CORPORATE MEMBER OF BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON ("BRI"). EXCEPT AS OTHERWISE PROVIDED IN THE CORPORATION'S ARTICLES OF INCORPORATION, ELSEWHERE IN THESE BYLAWS, OR IN THE LAWS OF THE STATE OF WASHINGTON, THE CORPORATE MEMBER SHALL HAVE THE SPECIFIC RIGHTS SET FORTH IN THE GOVERNANCE MATRIX. THE RIGHTS OF THE CORPORATE MEMBER SHALL BE FURTHER SUBJECT TO THE POWERS RESERVED TO CSH UNDER THE GOVERNANCE MATRIX (SUBJECT TO THE BYLAWS OF THE CORPORATE MEMBER) AND AS OTHERWISE SET FORTH IN THE BYLAWS OF THE CORPORATE MEMBER. IN ADDITION, SUBJECT TO THE BYLAWS OF THE CORPORATE MEMBER, THE RESERVED POWERS OF CSH SET FORTH IN THE GOVERNANCE MATRIX MAY BE UNILATERALLY EXERCISED BY CSH ON BEHALF OF THE CORPORATION, AT CSH'S SOLE DISCRETION, IF THE CORPORATION'S BOARD OF DIRECTORS FAILS TO ACT UPON SUCH MATTERS DESCRIBED IN THESE BYLAWS, OR IF THE CORPORATION'S BOARD OF DIRECTORS ATTEMPTS TO ACT IN A MANNER THAT CONFLICTS WITH OR OVERRIDES THE ACTIONS OR DESIRES OF CSH WITH RESPECT TO SUCH MATTERS. THE GOVERNANCE MATRIX MAY BE AMENDED FROM TIME TO TIME BY CSH, AND SUCH AMENDMENTS SHALL BE DEEMED TO BE A PART OF THESE BYLAWS WITHOUT FURTHER ACTION. THE CORPORATION SHALL BE DEEMED A "SUBSIDIARY" OF CSH FOR PURPOSES OF THE GOVERNANCE MATRIX. IN ADDITION TO THE RIGHTS RESERVED TO CSH UNDER THE GOVERNANCE MATRIX, CSH SHALL HAVE THE POWER TO TRANSFER ASSETS OF THE CORPORATION OR TO REQUIRE THE CORPORATION TO TRANSFER ASSETS TO CSH, TO THE EXTENT NECESSARY TO ACCOMPLISH CSH'S GOALS AND OBJECTIVES, AND TO PROVIDE FOR THE PAYMENT OF ALL INDEBTEDNESS OF CSH OR AN ENTITY CONTROLLED BY, CONTROLLING, OR UNDER COMMON CONTROL WITH CSH (FOR PURPOSES OF THIS SECTION, A "CSH AFFILIATE"), ISSUED OR INCURRED BY OR ON BEHALF OF CSH OR A CSH AFFILIATE IN FURTHERANCE OF CSH'S GOALS AND OBJECTIVES. THE CORPORATION SHALL NOT BE REQUIRED TO VIOLATE ITS CHARITABLE PURPOSES, THESE BYLAWS OR ITS ARTICLES OF INCORPORATION, THE TERMS OF ANY RESTRICTED GIFTS, OR THE COVENANTS OF ITS DEBT INSTRUMENTS OR OTHER CONTRACTS AS A RESULT OF ANY ASSET TRANSFERS MADE OR DIRECTED BY CSH. EXCEPT FOR TRANSFERS PREVIOUSLY APPROVED BY CSH, EITHER INDIVIDUALLY OR AS PART OF THE CSH HEALTHCARE SYSTEM BUDGET PROCESS, AND EXCEPT FOR TRANSFERS TO AN AFFILIATE OR SUBSIDIARY OF THE CORPORATION, THE CORPORATION SHALL NOT TRANSFER ASSETS TO ENTITIES OTHER THAN CSH OR CSH AFFILIATES WITHOUT THE APPROVAL OF CSH.
FORM 990, PART VI, SECTION B, LINE 11B NO REVIEW WAS OR WILL BE CONDUCTED.
FORM 990, PART VI, SECTION B, LINE 12C THE ORGANIZATION HAS A CONFLICTS OF INTEREST ("COI") POLICY (THE "POLICY") IN PLACE TO PROTECT THE INTERESTS OF COMMONSPIRIT HEALTH ("COMMONSPIRIT") IN CIRCUMSTANCES THAT MAY RESULT IN A CONFLICT BETWEEN PERSONAL INTERESTS OF A PERSON AND THE INTERESTS OF THE ORGANIZATION AND THOSE IT SERVES. COMMONSPIRIT'S COI POLICY APPLIES TO COMMONSPIRIT, ITS DIRECT AFFILIATES AND SUBSIDIARIES AND ANY RELATED ENTITY THE GOVERNING DOCUMENTS OF WHICH REQUIRE THE ENTITY TO COMPLY WITH COMMONSPIRIT POLICY (COLLECTIVELY THE "SYSTEM ENTITIES"). THE FOLLOWING PERSONS ARE REQUIRED TO DISCLOSE ACTUAL OR POTENTIAL CONFLICTS OF INTEREST AT LEAST ANNUALLY (VIA A FORMAL SYSTEM-ADMINISTERED SURVEY) IF THE PERSON'S AFFILIATION WITH COMMONSPIRIT CONTINUES: - MEMBERS OF CORPORATE AND COMMUNITY BOARDS OF SYSTEM ENTITIES - MEMBERS OF COMMITTEES OF CORPORATE AND COMMUNITY BOARDS OF SYSTEM ENTITIES - MEMBERS OF THE EXECUTIVE LEADERSHIP TEAM ("ELT") OF COMMONSPIRIT - CORPORATE OFFICERS OF SYSTEM ENTITIES - KEY EMPLOYEES AND HIGHEST COMPENSATED EMPLOYEES AS SPECIFIED BY THE INTERNAL REVENUE SERVICE FOR FORM 990 PURPOSES WHO ARE NOT OTHERWISE INCLUDED IN THE CATEGORIES ABOVE - EMPLOYEES OF SYSTEM ENTITIES AT THE VICE PRESIDENT LEVEL AND ABOVE - ALL INDIVIDUALS ENGAGED IN RESEARCH AT INSTITUTIONS OWNED OR OPERATED BY A SYSTEM ENTITY - SELECT EMPLOYEES AS DETERMINED FROM TIME TO TIME BY LEADERSHIP DISCLOSURE, REVIEW, AND MANAGEMENT OF PERCEIVED, POTENTIAL, OR ACTUAL CONFLICTS OF INTEREST ARE ACCOMPLISHED THROUGH A DEFINED COI DISCLOSURE REVIEW PROCESS. EACH PERSON IS REQUIRED TO PROMPTLY AND FULLY DISCLOSE ANY SITUATION OR CIRCUMSTANCE THAT MAY CREATE A CONFLICT OF INTEREST AS SOON AS SHE/HE BECOMES AWARE OF IT. IN ADDITION, AT THE INCEPTION OF AN INDIVIDUAL'S RELATIONSHIP WITH COMMONSPIRIT (E.G. HIRING, BOARD APPOINTMENT), AND FOR CERTAIN POSITIONS, ANNUALLY THEREAFTER, WRITTEN CONFLICT OF INTEREST DISCLOSURE FORMS MUST BE COMPLETED. A FAILURE TO DISCLOSE MAY RESULT IN DISCIPLINARY OR CORRECTIVE ACTIONS. REPORTED POTENTIAL OR ACTUAL CONFLICTS OF INTEREST ARE INITIALLY REVIEWED BY LEGAL, CORPORATE RESPONSIBILITY OR RESEARCH INTEGRITY STAFF. IF NECESSARY, A CONFLICT OF INTEREST MANAGEMENT PLAN IS DEVELOPED, WHICH PLAN SHALL BE SUBJECT TO ACCEPTANCE BY THE APPROPRIATE DIRECT MANAGER, SUPERVISOR, MEDICAL STAFF OFFICE, BOARD OR BOARD COMMITTEE (FOR BOARD, BOARD COMMITTEE, ELT OR CORPORATE OFFICER CONFLICTS), OR OTHER APPROPRIATE INDIVIDUAL OR BODY. ONCE ACCEPTED, THE CONFLICT OF INTEREST MANAGEMENT PLAN IS COMMUNICATED TO THE PERSON WITH THE ACTUAL OR POTENTIAL CONFLICT AND THE INDIVIDUAL MUST CONDUCT THEMSELVES IN CONFORMITY WITH THE PLAN. IN THE EVENT THAT A TRANSACTIONAL CONFLICT INTEREST ARISES IN CONNECTION WITH A SYSTEM ENTITY BOARD MEETING, THE CONFLICTED INDIVIDUAL MUST DISCLOSE THAT CONFLICT PRIOR TO OR AT THE BEGINNING OF THE MEETING IN WHICH THE MATTER IS TO BE CONSIDERED. THE CONFLICTED INDIVIDUAL IS EXCLUDED FROM VOTING ON THE TRANSACTION AND IS PROHIBITED FROM USING PERSONAL INFLUENCE WITH RESPECT TO THE MATTER, BUT IS NOT PROHIBITED FROM PROVIDING INPUT IF REQUESTED TO DO SO.
FORM 990, PART VI, SECTION B, LINE 15 THE VMMC COMPENSATION AND BENEFITS BOARD COMMITTEE, A COMMITTEE COMPOSED SOLELY OF INDEPENDENT DIRECTORS NONE OF WHOM HAVE A CONFLICT OF INTEREST, IS ACCOUNTABLE FOR SETTING REASONABLE TOTAL COMPENSATION PACKAGES THE PRESIDENT AND CHIEF EXECUTIVE CONSISTENT WITH BRI'S COMPENSATION PHILOSOPHY AND PRINCIPLES. THE COMMITTEE APPROVES ANNUAL GOALS AND PERFORMANCE CRITERIA WHICH ARE USED IN DETERMINING MERIT INCREASES AND VARIABLE COMPENSATION OPPORTUNITIES. THE COMMITTEE ASSESSES PERFORMANCE AGAINST THESE GOALS. THE COMMITTEE SELECTS AND ENGAGES A QUALIFIED INDEPENDENT COMPENSATION CONSULTANT TO REVIEW AND ANALYZE THE TOTAL COMPENSATION AND BENEFITS PACKAGES OF THE EXECUTIVES. THE COMMITTEE AS PART OF ITS ANALYSIS OBTAINS FROM THE COMPENSATION CONSULTANT APPROPRIATE COMPARABILITY DATA INCLUDING TOTAL COMPENSATION PAID BY SIMILARLY SITUATED ORGANIZATIONS FOR POSITIONS THAT ARE FUNCTIONALLY COMPARABLE TO EACH OF THE EXECUTIVES. THE COMMITTEE WILL CONSIDER THE SIGNIFICANT TERMS OF THE AGREEMENT WITH EACH EXECUTIVE INCLUDING THE TOTAL COMPENSATION TO BE PAID AND THE EMPLOYEE'S DUTIES AND RESPONSIBILITIES. CONSISTENT WITH THE COMPENSATION PHILOSOPHY AND PRINCIPLES, THE COMMITTEE APPROVES TOTAL COMPENSATION PACKAGES FOR EACH OF THE EXECUTIVES BASED ON INFORMATION PRESENTED TO THE COMMITTEE, REASONABLENESS, AND THE BEST INTEREST OF BRI. THE COMMITTEE'S DECISIONS REGARDING COMPENSATION FOR EACH EXECUTIVE ARE DOCUMENTED IN WRITTEN RESOLUTIONS AND MINUTES OF THE COMMITTEE. THE COMMITTEE PROMPTLY REPORTS ITS ACTIONS TO THE VMMC BOARD WHICH REPORTS ARE REFLECTED IN THE BOARD'S MINUTES.
FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION'S ARTICLES, BYLAWS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE MADE AVAILABLE UPON REQUEST.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ.
Cat. No. 51056K
Schedule O (Form 990) 2021


Additional Data


Software ID:  
Software Version:  
SCHEDULE R
(Form 990)
Department of the Treasury
Internal Revenue Service
Related Organizations and Unrelated Partnerships
MediumBulletComplete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
MediumBulletAttach to Form 990.
MediumBullet Go to www.irs.gov/Form990 for instructions and the latest information.

OMB No. 1545-0047
2021
Open to Public Inspection
Name of the organization
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
MASON
Employer identification number

91-0653422
Part I
Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a)
Name, address, and EIN (if applicable) of disregarded entity


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Total income


 		(e)
End-of-year assets


 		(f)
Direct controlling
entity










Part II
Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related tax-exempt organizations during the tax year.
(a)
Name, address, and EIN of related organization


(b)
Primary activity


 		(c)
Legal domicile (state
or foreign country)

 		(d)
Exempt Code section


 		(e)
Public charity status
(if section 501(c)(3))

 		(f)
Direct controlling
entity

 		(g)
Section 512(b)(13) controlled entity?
Yes No
(1)VIRGINIA MASON FRANCISCAN HEALTH
1149 MARKET ST

TACOMA,WA98402
86-1332353 		HEALTH CARE WA 501(C)(3) LINE 12B, II N/A
 
No












For Paperwork Reduction Act Notice, see the Instructions for Form 990.
Cat. No. 50135Y
Schedule R (Form 990) 2021
Schedule R (Form 990) 2021
Page 2
Part III
Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related organizations treated as a partnership during the tax year.
(a)
Name, address, and EIN of
related organization



 		(b)
Primary activity




 		(c)
Legal
domicile
(state or foreign
country)


 		(d)
Direct controlling
entity



 		(e)
Predominant income(related, unrelated, excluded from tax under sections 512-514)

(f)
Share of total income




 		(g)
Share of end-of-year
assets



 		(h)
Disproprtionate allocations?




 		(i)
Code V-UBI
amount in box 20 of
Schedule K-1
(Form 1065)
 		(j)
General or
managing
partner?



 		(k)
Percentage
ownership
Yes No Yes No












Part IV
Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34 because it had one or more related organizations treated as a corporation or trust during the tax year.
(a)
Name, address, and EIN of
related organization
 		(b)
Primary activity
 		(c)
Legal
domicile
(state or foreign
country)
 		(d)
Direct controlling
entity
 		(e)
Type of entity
(C corp, S corp,
or trust) 		(f)
Share of total income
 		(g)
Share of end-of-year
assets
 		(h)
Percentage
ownership
 		(i)
Section 512(b)(13) controlled entity?
Yes No












Schedule R (Form 990) 2021
Schedule R (Form 990) 2021
Page 3
Part V
Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note. Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule.
Yes
No
1 During the tax year, did the orgranization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity .....................
1a
 
No
b Gift, grant, or capital contribution to related organization(s) ............................
1b
 
No
c Gift, grant, or capital contribution from related organization(s) ............................
1c
 
No
d Loans or loan guarantees to or for related organization(s) ............................
1d
 
No
e Loans or loan guarantees by related organization(s) ............................
1e
 
No
f Dividends from related organization(s) ............................
1f
 
No
g Sale of assets to related organization(s) ............................
1g
 
No
h Purchase of assets from related organization(s) ............................
1h
 
No
i Exchange of assets with related organization(s) ............................
1i
 
No
j Lease of facilities, equipment, or other assets to related organization(s) .......................
1j
 
No
k Lease of facilities, equipment, or other assets from related organization(s) ......................
1k
 
No
l Performance of services or membership or fundraising solicitations for related organization(s) .....................
1l
 
No
m Performance of services or membership or fundraising solicitations by related organization(s) .................
1m
 
No
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ...................
1n
 
No
o Sharing of paid employees with related organization(s) ............................
1o
 
No
p Reimbursement paid to related organization(s) for expenses ............................
1p
 
No
q Reimbursement paid by related organization(s) for expenses ............................
1q
 
No
r Other transfer of cash or property to related organization(s) ............................
1r
 
No
s Other transfer of cash or property from related organization(s) ............................
1s
 
No
2
If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a)
Name of related organization 		(b)
Transaction
type (a-s) 		(c)
Amount involved 		(d)
Method of determining amount involved





Schedule R (Form 990) 2021
Schedule R (Form 990) 2021
Page 4
Part VI
Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue) that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a)
Name, address, and EIN of entity 		(b)
Primary activity 		(c)
Legal domicile
(state or foreign
country) 		(d)
Predominant income (related, unrelated, excluded from tax under sections 512-514)

(e)
Are all partners
section
501(c)(3)
organizations? 		(f)
Share of total income




 		(g)
Share of
end-of-year
assets 		(h)
Disproprtionate allocations? 		(i)
Code V-UBI
amount in box 20
of Schedule K-1
(Form 1065) 		(j)
General or
managing
partner? 		(k)
Percentage
ownership
Yes No Yes No Yes No






























Schedule R (Form 990) 2021
Schedule R (Form 990) 2021
Page 5
Part VII
Supplemental Information
Provide additional information for responses to questions on Schedule R. See instructions.
Return Reference Explanation
Schedule R (Form 990) 2021

Additional Data


Software ID:  
Software Version:  






TY 2022 AffiliatedGroupSchedule
Name:
BENAROYA RESEARCH INSTITUTE AT VIRGINIA
 
MASON
EIN:
91-0653422
Affiliated Group Business Name:
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
Address. Either US or Foreign Type:
1201 NINTH AVENUE
SEATTLE, WA98101    
EIN:
91-0653422
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
69,053,006
Total Exempt Purpose Expenditures:
69,053,006
Lobbying Nontaxable Amount:
1,000,000
Grassroots Nontaxable Amount:
250,000
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
0
Affiliated Group Business Name:
VIRGINIA MASON MEDICAL CENTER
Address. Either US or Foreign Type:
1100 NINTH AVENUE
SEATTLE, WA98101    
EIN:
91-0565539
Electing Organization Checkbox:
Total Grassroots Lobbying:
153,865
Total Direct Lobbying:
0
Total Lobbying Expenditures:
153,865
Other Exempt Purpose Expenditures:
1,163,284,113
Total Exempt Purpose Expenditures:
1,163,437,978
Lobbying Nontaxable Amount:
1,000,000
Grassroots Nontaxable Amount:
250,000
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
0
Affiliated Group Business Name:
VIRGINIA MASON INSTITUTE
Address. Either US or Foreign Type:
1100 NINTH AVENUE
SEATTLE, WA98101    
EIN:
26-3763656
Electing Organization Checkbox:
Total Grassroots Lobbying:
0
Total Direct Lobbying:
0
Total Lobbying Expenditures:
0
Other Exempt Purpose Expenditures:
3,373,533
Total Exempt Purpose Expenditures:
3,373,533
Lobbying Nontaxable Amount:
318,677
Grassroots Nontaxable Amount:
79,669
Tot Lobbying Grassroot Minus Non Tx:
0
Tot Lobby Expend Mns Lobbying Non Tx:
0
Share Of Excess Lobbying:
0