Attach to Form 990 or Form 990-EZ.
Go to
www.irs.gov/Form990 for instructions and the latest information.
| (i) Name of supported organization | (ii) EIN | (iii) Type of organization (described on lines 1- 10 above (see instructions)) | (iv) Is the organization listed in your governing document? | (v) Amount of monetary support (see instructions) | (vi) Amount of other support (see instructions) | |
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| Yes | No | |||||
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Total |
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Calendar year
(or fiscal year beginning in)
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(a) 2019 | (b) 2020 | (c) 2021 | (d) 2022 | (e) 2023 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grant.") .. | ||||||
| 2 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf .... | ||||||
| 3 | The value of services or facilities furnished by a governmental unit to the organization without charge.. | ||||||
| 4 | Total. Add lines 1 through 3 | ||||||
| 5 | The portion of total contributions by each person (other than a governmental unit or publicly supported organization) included on line 1 that exceeds 2% of the amount shown on line 11, column (f) .. | ||||||
| 6 | Public support. Subtract line 5 from line 4. | ||||||
Calendar year
(or fiscal year beginning in)
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(a) 2019 | (b) 2020 | (c) 2021 | (d) 2022 | (e) 2023 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 7 | Amounts from line 4.. | ||||||
| 8 | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources... | ||||||
| 9 | Net income from unrelated business activities, whether or not the business is regularly carried on.. | ||||||
| 10 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.).. | ||||||
| 11 | Total support. Add lines 7 through 10 | ||||||
Calendar year (or fiscal
year beginning in) ![]() |
(a) 2019 | (b) 2020 | (c) 2021 | (d) 2022 | (e) 2023 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 1 | Gifts, grants, contributions, and membership fees received. (Do not include any "unusual grants.") . | ||||||
| 2 | Gross receipts from admissions, merchandise sold or services performed, or facilities furnished in any activity that is related to the organization's tax-exempt purpose | ||||||
| 3 | Gross receipts from activities that are not an unrelated trade or business under section 513 ..... | ||||||
| 4 | Tax revenues levied for the organization's benefit and either paid to or expended on its behalf... | ||||||
| 5 | The value of services or facilities furnished by a governmental unit to the organization without charge | ||||||
| 6 | Total. Add lines 1 through 5 | ||||||
| 7a | Amounts included on lines 1, 2, and 3 received from disqualified persons | ||||||
| b | Amounts included on lines 2 and 3 received from other than disqualified persons that exceed the greater of $5,000 or 1% of the amount on line 13 for the year. | ||||||
| c | Add lines 7a and 7b.. | ||||||
| 8 | Public support. (Subtract line 7c from line 6.) | ||||||
Calendar year
(or fiscal year beginning in)
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(a) 2019 | (b) 2020 | (c) 2021 | (d) 2022 | (e) 2023 | (f) Total | |
|---|---|---|---|---|---|---|---|
| 9 | Amounts from line 6... | ||||||
| 10a | Gross income from interest, dividends, payments received on securities loans, rents, royalties and income from similar sources.. | ||||||
| b | Unrelated business taxable income (less section 511 taxes) from businesses acquired after June 30, 1975. | ||||||
| c | Add lines 10a and 10b. | ||||||
| 11 | Net income from unrelated business activities not included on line 10b, whether or not the business is regularly carried on. | ||||||
| 12 | Other income. Do not include gain or loss from the sale of capital assets (Explain in Part VI.) .. | ||||||
| 13 | Total support. (Add lines 9, 10c, 11, and 12.).. | ||||||
| Section A - Adjusted Net Income | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Net short-term capital gain | 1 | ||||
| 2 | Recoveries of prior-year distributions | 2 | ||||
| 3 | Other gross income (see instructions) | 3 | ||||
| 4 | Add lines 1 through 3 | 4 | ||||
| 5 | Depreciation and depletion | 5 | ||||
| 6 | Portion of operating expenses paid or incurred for production or collection of gross income or for management, conservation, or maintenance of property held for production of income (see instructions) | 6 | ||||
| 7 | Other expenses (see instructions) | 7 | ||||
| 8 | Adjusted Net Income (subtract lines 5, 6 and 7 from line 4) | 8 | ||||
| Section B - Minimum Asset Amount | (A) Prior Year |
(B) Current Year (optional) |
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| 1 | Aggregate fair market value of all non-exempt-use assets (see instructions for short tax year or assets held for part of year): | 1 | ||||
| a | Average monthly value of securities | 1a | ||||
| b | Average monthly cash balances | 1b | ||||
| c | Fair market value of other non-exempt-use assets | 1c | ||||
| d | Total (add lines 1a, 1b, and 1c) | 1d | ||||
| e |
Discount claimed for blockage or other factors (explain in detail in Part VI): |
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| 2 | Acquisition indebtedness applicable to non-exempt use assets | 2 | ||||
| 3 | Subtract line 2 from line 1d | 3 | ||||
| 4 | Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount, see instructions). | 4 | ||||
| 5 | Net value of non-exempt-use assets (subtract line 4 from line 3) | 5 | ||||
| 6 | Multiply line 5 by 0.035 | 6 | ||||
| 7 | Recoveries of prior-year distributions | 7 | ||||
| 8 | Minimum Asset Amount (add line 7 to line 6) | 8 | ||||
| Section C - Distributable Amount | Current Year | |||||
| 1 | Adjusted net income for prior year (from Section A, line 8, Column A) | 1 | ||||
| 2 | Enter 85% of line 1 | 2 | ||||
| 3 | Minimum asset amount for prior year (from Section B, line 8, Column A) | 3 | ||||
| 4 | Enter greater of line 2 or line 3 | 4 | ||||
| 5 | Income tax imposed in prior year | 5 | ||||
| 6 | Distributable Amount. Subtract line 5 from line 4, unless subject to emergency temporary reduction (see instructions) | 6 | ||||
| Section D - Distributions | Current Year | |
|---|---|---|
| 1 Amounts paid to supported organizations to accomplish exempt purposes | 1 | |
|
2
Amounts paid to perform activity that directly furthers exempt purposes of supported organizations, in excess of income from activity |
2 | |
| 3 Administrative expenses paid to accomplish exempt purposes of supported organizations | 3 | |
| 4 Amounts paid to acquire exempt-use assets | 4 | |
| 5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI) | 5 | |
| 6 Other distributions (describe in Part VI). See instructions | 6 | |
| 7Total annual distributions. Add lines 1 through 6. | 7 | |
|
8
Distributions to attentive supported organizations to which the organization is responsive (provide details in Part VI). See instructions |
8 | |
| 9 Distributable amount for 2023 from Section C, line 6 | 9 | |
| 10 Line 8 amount divided by Line 9 amount | 10 | |
| Section E - Distribution Allocations (see instructions) |
(i) Excess Distributions |
(ii) Underdistributions Pre-2023 |
(iii) Distributable Amount for 2023 |
|
|---|---|---|---|---|
| 1 Distributable amount for 2023 from Section C, line 6 | ||||
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2
Underdistributions, if any, for years prior to 2023 (reasonable cause required-- explain in Part VI).
See instructions. |
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| 3 Excess distributions carryover, if any, to 2023: | ||||
| a From 2018....... | ||||
| b From 2019....... | ||||
| c From 2020....... | ||||
| d From 2021....... | ||||
| e From 2022....... | ||||
| fTotal of lines 3a through e | ||||
| g Applied to underdistributions of prior years | ||||
| h Applied to 2023 distributable amount | ||||
|
i
Carryover from 2018 not applied (see instructions) |
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| j Remainder. Subtract lines 3g, 3h, and 3i from line 3f. | ||||
| 4Distributions for 2023 from Section D, line 7: | ||||
| $ | ||||
| a Applied to underdistributions of prior years | ||||
| b Applied to 2023 distributable amount | ||||
| c Remainder. Subtract lines 4a and 4b from line 4. | ||||
|
5
Remaining underdistributions for years prior to 2023, if any. Subtract lines 3g and 4a from line 2. If the amount is greater than zero, explain in Part VI. See instructions. |
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6
Remaining underdistributions for 2023. Subtract lines 3h and 4b from line 1. If the amount is greater than zero, explain in Part VI. See instructions. |
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7 Excess distributions carryover to 2024. Add lines 3j and 4c. |
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| 8 Breakdown of line 7: | ||||
| a Excess from 2019..... | ||||
| b Excess from 2020..... | ||||
| c Excess from 2021..... | ||||
| d Excess from 2022..... | ||||
| e Excess from 2023..... | ||||
| Facts And Circumstances Test |
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| Return Reference | Explanation |
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| Schedule A, Part I, Line 4 MEDICAL RESEARCH HOSPITAL AFFILIATION | Cooperation Agreements and Collaborations Since October 2000, the Stowers Institute has maintained a cooperative relationship and agreement with Children's Mercy Kansas City. The Stowers Institute conducts medical research in conjunction with the University of Kansas (KU) and its affiliates the University of Kansas Hospital Authority and the University of Kansas Medical Center (KUMC), pursuant to a written memorandum of understanding. KUMC is the academic health science center for the largest public research university in the state of Kansas. KUMC offers programs and services that focus on education, research, patient care, and community engagement. As of June 30, 2024, five KUMC students have received M.S. degrees and 52 KUMC students have received Ph.D. degrees for thesis work performed in Stowers Institute labs. KUMC is affiliated with the University of Kansas Health System, a nonprofit independent hospital system co-located with the main KUMC campus in Kansas City, Kansas. During July 2023 - June 2024, 14 Stowers research program leaders served as adjunct faculty in three KUMC departments. These appointments included 10 full professors, three associate professors, and one assistant professor. Thirty of the Stowers Institute's 48 original research publications included both Stowers Institute and KUMC affiliations. Seven KUMC students performed predoctoral research in Stowers labs. The Stowers Institute is also a consortium member of the University of Kansas Cancer Center at KUMC, a cancer research and care partnership spanning two states and involving collaboration among researchers, physicians, and cancer support professionals in foundational, translational, and clinical research areas. In June 2012, the NIH's National Cancer Institute (NCI) named the University of Kansas Cancer Center an NCI-Designated Cancer Center, part of a pillar of federal cancer research efforts and integral to the NCI's programs for studying, treating, and preventing cancer. In 2022, the NCI named the University of Kansas Cancer Center an NCI-Designated Comprehensive Cancer Center - the highest honor bestowed by the NCI, the only such center in the region, and one of only 57 centers in the United States. During July 2023 - June 2024, 10 Stowers research program leaders were members of the University of Kansas Cancer Center's Cancer Biology Research Program, including Linheng Li, Ph.D., who serves as co-leader of the program. During July 2023 - June 2024, Stowers Investigator Linheng Li, Ph.D., continued a collaboration with the University of Kansas Cancer Center and Children's Mercy Kansas City to investigate approaches to treat leukemia. This research focuses on targeting cancer stem cells to help reduce the recurrence of cancer after a patient enters into remission. The collaboration builds on foundational research from the Li Lab that has characterized cancer stem cells at molecular and cellular levels, has produced peer-reviewed scientific publications, and is related to a Children's Mercy clinical research study. Li and Roy Jensen, M.D., Vice Chancellor and Director of the University of Kansas Cancer Center, coauthored the Cancer Hallmarks Review, "Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells," published July 1, 2023, in Cancer Research. During July 2023 - June 2024, the Stowers Institute conducted research in conjunction with the private, nonprofit Marine Biological Laboratory (MBL), an affiliate of the University of Chicago located in Woods Hole, Massachusetts. Since 1888, the MBL has hosted thousands of researchers, students, and faculty from all over the world to fulfill its mission of scientific discovery by exploring fundamental biology, understanding biodiversity and the environment, and informing the human condition through research and education. Since 2022, a Lease Agreement with the MBL provides the Stowers Institute a dedicated, year-round laboratory on the MBL campus and access to services and resources such as shared research and equipment rooms, a shared microscopy facility, and the Marine Resources Center, a highly advanced facility for maintaining, culturing, and providing aquatic organisms. During July 2023 - June 2024, Stowers Institute scientists collaborated with researchers at 126 national and 75 international institutions including dozens of hospitals, medical centers, and medical schools. Many of these collaborations resulted in discoveries that merited publication in leading peer-reviewed scientific journals and/or successfully funded grant awards. The Stowers Institute participated in research collaborations in conjunction with the following US hospitals, pursuant to an understanding to maintain continuing close cooperation in the active conduct of medical research during July 2023 - June 2024: Albert Einstein College of Medicine; Baylor College of Medicine; Boston Children's Hospital; Boston University Chobanian and Avedisian School of Medicine; Burrell College of Osteopathic Medicine; Children's Mercy Kansas City; Cincinnati Children's Hospital Medical Center; College of Osteopathic Medicine at New York Institute of Technology; Columbia University Irving Medical Center; Dana-Farber Cancer Institute; Duke University School of Medicine; Fred Hutchinson Cancer Center; George Washington University School of Medicine and Health Sciences; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Indiana University School of Medicine; Jacobs School of Medicine and Biomedical Sciences; Johns Hopkins University School of Medicine; Louisiana State University Health Sciences Center - New Orleans; Northwestern University Feinberg School of Medicine; Oregon Health and Science University School of Medicine; Rush University Medical Center; Stanford University School of Medicine; Texas Tech University Health Sciences Center El Paso; UConn Health; University of California, Los Angeles David Geffen School of Medicine; University of California, San Francisco School of Medicine; University of Colorado Anschutz Medical Campus; University of Iowa Carver College of Medicine; University of Kansas Cancer Center; University of Kansas Medical Center; University of Miami Miller School of Medicine; University of Michigan Medical School; University of Missouri - Kansas City School of Medicine; University of Nebraska Medical Center; University of North Texas Health Science Center; University of Pittsburgh Cancer Institute; University of Southern California Keck School of Medicine; University of Tennessee Health Science Center; University of Texas Health - San Antonio; University of Texas MD Anderson Cancer Center; University of Texas Southwestern Medical Center; University of Utah School of Medicine; University of Washington School of Medicine; Virginia Commonwealth University School of Medicine; Washington University School of Medicine in St. Louis; and Yale School of Medicine. To carry out the research described in the following examples, the Stowers Institute and hospital, medical center, or medical school entered into a Cooperation Agreement pursuant to which they agreed to establish, develop, administer, and maintain continuing close cooperation in the active conduct of medical research, including through specific cooperative efforts in the areas of research, sharing of information, pursuant of joint grants, interaction of staff, adjunct/joint appointments, and sharing of facilities. To assure the success of their cooperative relationship, each agreed to engage in effective, coordinated, and ongoing planning, oversight, and communication, and to commit the necessary resources, both human and monetary, to support, facilitate, and promote the cooperation. Joint medical research on the characterization of intestinal stem cells: The Li Lab performed joint medical research on the characterization of intestinal stem cells with collaborators at Cincinnati Children's Hospital Medical Center; David Geffen School of Medicine at the University of California, Los Angeles; Oregon Health and Science University School of Medicine; Stanford University School of Medicine; and University of Pittsburgh Cancer Institute. Intestinal diseases ranging from Crohn's disease to colitis to cancer may benefit from intestinal stem cell therapies. This research advances the understanding of the biology of stem cells that reside in the intestine and explores how they can be used to treat and cure intestinal diseases. This research collaboration is supported in part by an NIH grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases. |
| Schedule A, Part I, Line 4 MEDICAL RESEARCH HOSPITAL AFFILIATION - CONT'D | Joint medical research on sensory hair cell regeneration: The Piotrowski Lab performed joint medical research on zebrafish hair cell regeneration with collaborators at the Stanford University School of Medicine, University of Southern California Keck School of Medicine, Baylor College of Medicine, and Sunnybrook Research Institute in Toronto, Canada. In humans, hearing loss caused by inner ear hair cell degeneration is one of the most widespread sensory disabilities in the world with 30% of people between ages 65-75 being affected. In humans and mammals, hair cells are unable to regenerate, so any damage or loss of hair cells is permanent. In zebrafish, however, hair cells regenerate throughout life. The goal of this work is to determine gene regulatory networks underlying zebrafish hair cell regeneration. The results will help identify strategies to restore damaged or lost hair cells in mammals. This research is supported in part by a grant from the Hearing Health Foundation. Joint medical research on the molecular origins of female reproductive aging: In collaboration with researchers from Northwestern University Feinberg School of Medicine, the Gerton Lab performed medical research on the molecular origins of female reproductive aging, which impacts fertility, endocrine function, and overall health. The goal of this work is to examine genomic instability in the egg as a driver of the aging ovarian innate immune response. This project provides a novel paradigm for female reproductive aging, a major reproductive transition. This research is supported in part by an NIH grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Joint medical research on genetic variants underlying rare diseases in children: In collaboration with researchers from Children's Mercy Kansas City, the Trainor Lab performed medical research on the utilization of a pediatric genetic data repository to guide the development of scalable cell-based systems capable of identifying genetic variants and profiling the molecular consequences of disease-associated variants in pediatric rare diseases. A primary goal of this research is to build a first-of-its-kind platform to accelerate the process of translating the clinical detection of birth defect-associated genetic variants into meaningful and potentially actionable diagnoses. This research is supported in part by an NIH grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and a grant from BioNexus KC. Joint medical research on brain structure and nerve cell circuitry underlying odor perception: In collaboration with researchers from the University of Texas Southwestern Medical Center and Cornell University, the Yu Lab performed medical research to identify the key anatomical structures and responses in the brain that are responsible for odor perception. This project uses genetic approaches to perturb and label individual components of the mouse olfactory system with the goal of correlating nerve cell responses to odor-guided behaviors. This research aims to provide a comprehensive understanding of normal and pathological function of the nervous systems. This research is supported in part by an NIH grant from the National Institute on Deafness and Other Communication Disorders. The associated original research protocol, "Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2," was published September 10, 2023, in Methods in Molecular Biology. |
| Software ID: | 23017437 |
| Software Version: | 2023v6.0 |
| Return Reference | Explanation |
|---|---|
| Form 990, Part III, Line 4a PROGRAM SERVICE DESCRIPTION | July 2023 - June 2024 Program Service Accomplishments The Stowers Institute for Medical Research ("Stowers Institute "Institute") is a private, nonprofit medical research organization. The Institute was founded in 1994 by Jim and Virginia Stowers, who each survived a bout with cancer and subsequently dedicated their fortune to supporting fundamental and multidisciplinary research addressing biological questions that will provide novel insights and long-term solutions to human diseases. The Stowers Institute conducts fundamental biomedical research aimed at advancing our understanding of the intricate molecular and cellular mechanisms that govern life. By investigating genes, proteins, and biological processes, scientists at the Stowers explore how cells proliferate, differentiate into various tissues and organs, regenerate, and undergo programmed cell death. This comprehensive approach to studying cellular and organismal biology provides crucial insights into the underlying causes of numerous diseases, including cancer, birth defects, and neurodegenerative disorders. Historically, such foundational research has proven to be the cornerstone for developing novel therapeutic strategies, preventive measures, and potential cures for a wide range of human ailments. The Institute's commitment to basic research not only advances scientific knowledge but also lays the groundwork for future medical breakthroughs that can significantly impact human health. July 2023 - June 2024 Notable Research Results During July 2023 - July 2024, Stowers research teams made discoveries meriting publication in leading peer-reviewed scientific journals - 48 original research papers in all. Stowers research teams also produced 21 other publications including reviews, commentaries, book chapters, and books. Some of the highlights among these papers and other advances involving Stowers research include the following: The Gerton Lab discovered evidence of unintended impacts on cells by anti-cancer drugs. The formation of cellular machinery that manufactures proteins is paramount for cancer cells to grow and divide. The researchers screened over 1,000 existing anti-cancer drugs to assess how they impact the structure and function of the nucleolus-the location in the cell nucleus where the protein-manufacturing machinery is assembled-and identified categories of drugs that cause distinct nucleolar shapes. The classification system provides a resource for other researchers to use. Insights from this research, published August 23, 2023, in Development, could potentially improve the success rate of cancer drug development. The Hawley Lab uncovered findings that may help explain why some men do not make enough sperm to fertilize an egg. In most sexually reproducing species, including humans, a critical protein structure resembling a lattice-like bridge needs to be built properly to produce sperm and egg cells. The researchers discovered that in mice, changing a single and very specific point in this bridge caused it to collapse, leading to infertility. The results, published October 20, 2023, in Science Advances, may provide insight into human infertility in males due to similar problems with meiosis. The Krumlauf Lab discovered that the sea lamprey hindbrain, the brain region responsible for governing blood pressure and heart rate, is built using the same molecular and genetic toolkit as mouse and human hindbrains. Despite sea lampreys lacking a jaw, a key feature in vertebrate evolution, they use the same molecular cue called retinoic acid, or vitamin A, to guide the genes that form this basic part of the brain. This study was published February 20, 2024, in Nature Communications. The Rohner Lab identified a gene involved in the development of fatty liver, a condition that can occur from both overeating and starvation. Fatty liver can lead to liver damage and disease, but naturally starvation-resistant cavefish are able to avoid fatty liver under starvation conditions at early developmental stages in which the gene is not activated. The team, in collaboration with researchers from Iowa State University and Universite Libre de Bruxelles, Belgium, showed that the gene, which has counterparts in many other species including humans, can be targeted by an existing drug candidate to protect against liver damage. The findings, published March 11, 2024, in Life Science Alliance, have implications for understanding and potentially addressing liver conditions in humans. Comprehensive Lists of Original Research Papers, Reviews, Commentaries, Chapters, and Books Published July 2023 - June 2024 Original Research Papers 1. Modeling the Evolution of S. pombe Populations with Multiple Killer Meiotic Drivers. Lopez Hernandez JF, Rubinstein BY, Unckless RL, Zanders SE. G3 (Bethesda). 2024:jkae142. 2. Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Zhao R, Moore EL, Gogol MM, Unruh JR, Yu Z, Scott AR, Wang Y, Rajendran NK, Trainor PA. eLife. 2024 Jun 14;13:RP92844. 3. Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties. Harel I, Chen YR, Ziv I, Singh PP, Heinzer D, Navarro Negredo P, Goshtchevsky U, Wang W, Astre G, Moses E, McKay A, Machado BE, Hebestreit K, Yin S, Sanchez Alvarado A, Jarosz DF, Brunet A. Cell Rep. 2024 Jun 25;43(6):112787. 4. Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species. Ho DV, Tormey D, Odell A, Newton AA, Schnittker RR, Baumann DP, Neaves WB, Schroeder MR, Sigauke RF, Barley AJ, Baumann P. eLife. 2024 Jun 7;13:e97035. 5. Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury. Malagola E, Vasciaveo A, Ochiai Y, Kim W, Zheng B, Zanella L, Wang ALE, Middelhoff M, Nienhuser H, Deng L, Wu F, Waterbury QT, Belin B, LaBella J, Zamechek LB, Wong MH, Li L, Guha C, Cheng CW, Yan KS, Califano A, Wang TC. Cell. 2024 Jun 6;187(12):3056-3071.e17. 6. Astyanax mexicanus surface and cavefish chromosome-scale assemblies for trait variation discovery. Warren WC, Rice ES, X M, Roback E, Keene A, Martin F, Ogeh D, Haggerty L, Carroll RA, McGaugh S, Rohner N. G3 (Bethesda). 2024 Aug 7;14(8):jkae103. 7. A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration. Doddihal V, Mann FG, Jr., Ross EJ, McKinney MC, Guerrero-Hernandez C, Brewster CE, McKinney SA, Sanchez Alvarado A. Proc Natl Acad Sci U S A. 2024;121:e2321919121. 8. Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest. Pallares HM, Ledesma MMGL, Rouco SO, Castellano LA, Costa Navarro GS, Fernandez-Alvarez AJ, Dreiz MJ, Aidas DV, Alvarez DE, Bazzini A, Gamarnik AV. Nucleic Acids Res. 2024 Jun 25:gkae507. 9. Niche Tet maintains germline stem cells independently of dioxygenase activity. Tu R, Ping Z, Liu J, Tsoi ML, Song X, Liu W, Xie T. EMBO J. 2024;43:1570-1590. 10. Distinct epicardial gene regulatory programs drive development and regeneration of the zebrafish heart. Weinberger M, Simoes FC, Gungoosingh T, Sauka-Spengler T, Riley PR. Dev Cell. 2024;59:351-367 e356. 11. Host evolution shapes cavefish gut microbiome. Riddle MR, Nguyen NK, Nave M, Peuss R, Maldonado E, Rohner N, Tabin CJ. Ecol Evol. 2024;14:e11192. 12. The prevalence of copy number increase at multiallelic copy number variants associated with cave colonization. Pokrovac I, Rohner N, Pezer Z. Mol Ecol. 2024;33:e17339. 13. Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis. Sabin KZ, Chen S, Hill EM, Weaver KJ, Yonke J, Kirkman M, Redwine WB, Klompen AML, Zhao X, Guo F, McKinney MC, Dewey JL, Gibson MC. Dev Biol. 2024;510:50-65. 14. The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes. Makova KD, Pickett BD, Harris RS, Hartley GA, Cechova M, Pal K, Nurk S, Yoo D, Li Q, Hebbar P, McGrath BC, Antonacci F, Aubel M, Biddanda A, Borchers M, Bornberg-Bauer E, Bouffard GG, Brooks SY, Carbone L, Carrel L, Carroll A, Chang PC, Chin CS, Cook DE, Craig SJC, de Gennaro L, Diekhans M, Dutra A, Garcia GH, Grady PGS, Green RE, Haddad D, Hallast P, Harvey WT, Hickey G, Hillis DA, Hoyt SJ, Jeong H, Kamali K, Pond SLK, LaPolice TM, Lee C, Lewis AP, Loh YE, Masterson P, McGarvey KM, McCoy RC, Medvedev P, Miga KH, Munson KM, Pak E, Paten B, Pinto BJ, Potapova T, Rhie A, Rocha JL, Ryabov F, Ryder OA, Sacco S, Shafin K, Shepelev VA, Slon V, Solar SJ, Storer JM, Sudmant PH, Sweetalana, Sweeten A, Tassia MG, Thibaud-Nissen F, Ventura M, Wilson MA, Young AC, Zeng H, Zhang X, Szpiech ZA, Huber CD, Gerton JL, Yi SV, Schatz MC, Alexandrov IA, Koren S, O'Neill RJ, Eichler EE, Phillippy AM. Nature 2024;630:401-411. |
| Form 990, Part III, Line 4a PROGRAM SERVICE DESCRIPTION - CONT'D | 15. Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity. Pozo-Morales M, Cobham AE, Centola C, McKinney MC, Liu P, Perazzolo C, Lefort A, Libert F, Bai H, Rohner N, Singh SP. Life Sci Alliance 2024;7:e202302458. 16. Compartmentalized ocular lymphatic system mediates eye-brain immunity. Yin X, Zhang S, Lee JH, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo LH, Poulet M, Fischer S, Zhou T, Mohammed FS, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas JL, Saltzman WM, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Nature. 2024 Apr;628(8006):204-211. 17. The variation and evolution of complete human centromeres. Logsdon GA, Rozanski AN, Ryabov F, Potapova T, Shepelev VA, Catacchio CR, Porubsky D, Mao Y, Yoo D, Rautiainen M, Koren S, Nurk S, Lucas JK, Hoekzema K, Munson KM, Gerton JL, Phillippy AM, Ventura M, Alexandrov IA, Eichler EE. Nature. 2024;629:136-145. 18. A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster. Hughes SE, Price A, Briggs S, Staber C, James M, Anderson M, Hawley RS. G3 (Bethesda). 2024 Apr 3;14(4):jkae028. 19. miR-430 regulates zygotic mRNA during zebrafish embryogenesis. Baia Amaral D, Egidy R, Perera A, Bazzini AA. Genome Biol. 2024 Mar 19;25(1):74. 20. Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation. Bedois AMH, Parker HJ, Price AJ, Morrison JA, Bronner ME, Krumlauf R. Nat Commun. 2024;15:1538. 21. 3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment. Biswas T, Rajendran N, Hassan H, Li H, Zhao C, Rohner N. J Exp Zool B Mol Dev Evol. 2024 May;342(3):301-312. 22. Proteome-Wide Identification of RNA-Dependent Proteins: An Emerging Role of RNAs in Plasmodium falciparum Protein Complexes. Hollin T, Abel S, Banks C, Hristov B, Prudhomme J, Hales K, Florens L, Stafford Noble W, Le Roch KG. Nat Commun. 2024;15:1365. 23. Multiple reorganizations of the lateral elements of the synaptonemal complex facilitate homolog segregation in Bombyx mori oocytes. Xiang Y, Tsuchiya D, Yu Z, Zhao X, McKinney S, Unruh J, Slaughter B, Lake CM, Hawley RS. Curr Biol. 2024 Jan 22;34(2):352-360.e4. 24. Quantifying Cell Proliferation Through Immunofluorescence on Whole-Mount and Cryosectioned Regenerating Caudal Fins in African Killifish. Granillo AO, Schnittker RR, Wang W, Sanchez Alvarado A. Bio Protoc. 2023;13:e4908. 25. Topological structures and syntenic conservation in sea anemone genomes. Zimmermann B, Montenegro JD, Robb SMC, Fropf WJ, Weilguny L, He S, Chen S, Lovegrove-Walsh J, Hill EM, Chen CY, Ragkousi K, Praher D, Fredman D, Schultz D, Moran Y, Simakov O, Genikhovich G, Gibson MC, Technau U. Nat Commun. 2023;14:8270. 26. Distinct states of nucleolar stress induced by anti-cancer drugs. Potapova T, Unruh J, Conkright-Fincham J, Banks CAS, Florens L, Schneider DHG, Gerton JL. eLife. 2023 Dec 15;12:RP88799. 27. Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance. Socodato R, Almeida TO, Portugal CC, Santos ECS, Tedim-Moreira J, Galvao-Ferreira J, Canedo T, Baptista FI, Magalhaes A, Ambrosio AF, Brakebusch C, Rubinstein B, Moreira IS, Summavielle T, Pinto IM, Relvas JB. Cell Rep. 2023;42:113447. 28. Defining a core configuration for human centromeres during mitosis. Sen Gupta A, Seidel C, Tsuchiya D, McKinney S, Yu Z, Smith SE, Unruh JR, Gerton JL. Nat Commun. 2023;14:7947. 29. FGF2 antiproliferative effect in K-ras-driven tumor cells involves modulation of rRNA and nucleolus. de Luna Vitorino FN, Levy MJ, Mansano Wailemann RA, Lopes M, Silva ML, Sardiu ME, Garcia BA, Motta MCM, Oliveira CC, Armelin HA, Florens LA, Washburn MP, da Cunha JPC. J Cell Sci. 2023 Nov 15;136(22):jcs260989. 30. Reproductive seasonality of Astyanax mexicanus. Espinasa L, Rohner N, Retaux S. Zool Res. 2023;44:698-700. 31. The multi-lineage transcription factor ISLI controls cardiomyocyte cell fate through interaction with NKX2.5. Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Huttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, Srivastava D. Stem Cell Rep. 2023 Nov 14;18(11):2138-2153. 32. Short tandem repeats bind transcription factors to tune eukaryotic gene expression. Horton CA, Alexandari AM, Hayes MGB, Marklund E, Schaepe JM, Aditham AK, Shah N, Suzuki PH, Shrikumar A, Afek A, Greenleaf WJ, Gordan R, Zeitlinger J, Kundaje A, Fordyce PM. Science. 2023;381:eadd1250. 33. Phylogeographic relationships and morphological evolution between cave and surface Astyanax mexicanus populations (De Filippi 1853) (Actinopterygii, Characidae). Garduno-Sanchez M, Hernandez-Lozano J, Moran RL, Miranda-Gamboa R, Gross JB, Rohner N, Elliott WR, Miller J, Lozano-Vilano L, McGaugh SE, Ornelas-Garcia CP. Mol Ecol. 2023;32:5626-5644. 34. Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells. Li L, Jensen RA. Cancer Res. 2023;83:2096-2104. 35. The Swi-Snf chromatin remodeling complex mediates gene repression through metabolic control. Church MC, Price A, Li H, Workman JL. Nucleic Acids Res. 2023;51:10278-10291. 36. SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis. Billmyre KK, Kesler EA, Tsuchiya D, Corbin TJ, Weaver K, Moran A, Yu Z, Adams L, Delventhal K, Durnin M, Davies OR, Hawley RS. Sci Adv. 2023;9:eadi1562. 37. Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development. Ramalingam V, Yu X, Slaughter BD, Unruh JR, Brennan KJ, Onyshchenko A, Lange JJ, Natarajan M, Buck M, Zeitlinger J. Nat Commun. 2023;14:5862. 38. Phase plane dynamics of ERK phosphorylation. Shvartsman SY, McFann S, Wuhr M, Rubinstein BY. J Biol Chem. 2023 Nov;299(11):105234. 39. Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy. Michell-Robinson MA, Watt KEN, Grouza V, Macintosh J, Pinard M, Tuznik M, Chen X, Darbelli L, Wu CL, Perrier S, Chitsaz D, Uccelli NA, Liu H, Cox TC, Muller CW, Kennedy TE, Coulombe B, Rudko DA, Trainor PA, Bernard G. Brain. 2023 Dec 1;146(12):5070-5085. 40. rRNA transcription is integral to phase separation and maintenance of nucleolar structure. Dash S, Lamb MC, Lange JJ, McKinney MC, Tsuchiya D, Guo F, Zhao X, Corbin TJ, Kirkman M, Delventhal K, Moore EL, McKinney S, Shiang R, Trainor PA. PLoS Genet. 2023;19:e1010854. 41. Cell-type profiling of the sympathetic nervous system using spatial transcriptomics and spatial mapping of mRNA. Kasemeier-Kulesa JC, Morrison JA, McKinney S, Li H, Gogol M, Hall K, Chen S, Wang Y, Perera A, McLennan R, Kulesa PM. Dev Dyn. 2023;252:1130-1142. 42. The complete sequence of a human Y chromosome. Rhie A, Nurk S, Cechova M, Hoyt SJ, Taylor DJ, Altemose N, Hook PW, Koren S, Rautiainen M, Alexandrov IA, Allen J, Asri M, Bzikadze AV, Chen NC, Chin CS, Diekhans M, Flicek P, Formenti G, Fungtammasan A, Garcia Giron C, Garrison E, Gershman A, Gerton JL, Grady PGS, Guarracino A, Haggerty L, Halabian R, Hansen NF, Harris R, Hartley GA, Harvey WT, Haukness M, Heinz J, Hourlier T, Hubley RM, Hunt SE, Hwang S, Jain M, Kesharwani RK, Lewis AP, Li H, Logsdon GA, Lucas JK, Makalowski W, Markovic C, Martin FJ, Mc Cartney AM, McCoy RC, McDaniel J, McNulty BM, Medvedev P, Mikheenko A, Munson KM, Murphy TD, Olsen HE, Olson ND, Paulin LF, Porubsky D, Potapova T, Ryabov F, Salzberg SL, Sauria MEG, Sedlazeck FJ, Shafin K, Shepelev VA, Shumate A, Storer JM, Surapaneni L, Taravella Oill AM, Thibaud-Nissen F, Timp W, Tomaszkiewicz M, Vollger MR, Walenz BP, Watwood AC, Weissensteiner MH, Wenger AM, Wilson MA, Zarate S, Zhu Y, Zook JM, Eichler EE, O'Neill RJ, Schatz MC, Miga KH, Makova KD, Phillippy AM. Nature. 2023;621:344-354. 43. Gap Junction-transported cAMP from the Niche Controls Stem Cell Progeny Differentiation. Tu R, Tang XA, Xu R, Ping Z, Yu Z, Xie T. PNAS. 2023;120:e2304168120. 44. Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Varberg KM, Dominguez EM, Koseva B, Varberg JM, McNally RP, Moreno-Irusta A, Wesley ER, Iqbal K, Cheung WA, Schwendinger-Schreck C, Smail C, Okae H, Arima T, Lydic M, Holoch K, Marsh C, Soares MJ, Grundberg E. Nat Commun. 2023;14:4826. 45. Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation. Brennan KJ, Weilert M, Krueger S, Pampari A, Liu HY, Yang AWH, Morrison JA, Hughes TR, Rushlow CA, Kundaje A, Zeitlinger J. Dev Cell 2023;58:1-19. 46. Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface. Liu Q, Fong B, Yoo S, Unruh JR, Guo F, Yu Z, Chen J, Si K, Li R, Zhou C. Proc Natl Acad Sci U S A. 2023;120:e2300475120. |
| Form 990, Part III, Line 4a PROGRAM SERVICE DESCRIPTION - CONT'D | 47. Gas-assisted microfluidic step-emulsification for generating micron- and submicron-sized droplets. Huang B, Ge X, Rubinstein BY, Chen X, Wang L, Xie H, Leshansky AM, Li Z. Microsyst Nanoeng. 2023;9:86. 48. Cavefish mount a rapid and sustained regenerative response following skeletal muscle injury. Olsen L, Hassan H, Xia F, Keaton S, Rohner N. Zool Res. 2023;44:776-778. Reviews, Commentaries, Chapters, Books 1. Tracing embryonic hematopoiesis guides induction of pluripotent stem cells to hematopoietic progenitors. Mao X, Li L. Dev Cell. 2024;59:1093-1095. 2. Navigating the post-pandemic terrain: lessons in resilience and adaptation. Zhao C, Chiriboga LA, Chlipala EA. J Histotechnol. 2024 Jun;47(2):55-56. 3. The SWI/SNF chromatin remodeling complex: a critical regulator of metabolism. Church MC, Workman JL. Biochem Soc Trans. 2024 Jun 26;52(3):1327-1337. 4. Deciphering Molecular Orchestrations: XooClp Integrates Environmental Sensing and Virulence Regulation in Xanthomonas oryzae pv. oryzae. Sankari S, Lovelace AH. Mol Plant Microbe Interact. 2024 Apr;37(4):355-356. 5. From Darkness to Discovery: Evolutionary, Adaptive and Translational Genetic Insights from Cavefish. Swaminathan A, Xia F, Rohner N. Trends Genet. 2024;40:24-38. 6. A working model for the formation of Robertsonian chromosomes. Gerton JL. J Cell Sci. 2024;137:jcsw261912. 7. Activitydependent formation of the topographic map and the critical period in the development of mammalian olfactory system. Fang A, Yu CR. Genesis. 2024;62:e23586. 8. Pluripotency of a founding field: rebranding developmental biology. Rodgers CD, Memiya C, Arur S, Babonis L, Barres M, Bartlett M, Behringer RR, Benham-Pyle BW, Bergmann D, Blackman B, Brown CT, Browne B, Camacho J, Chabu CY, Chow I, Cleaver O, Cool J, Dennis MY, Dickenson AJ, Di Talia S, Frank M, Gillmor S, Haag ES, Hariharan IK, Harland R, Husbands A, Jerome-Majewska L, Koenig K, Labonne C, Layden MJ, Lowe C, Mani M, Martick M, McKown K, Moens C, Mosimann C, Onyenedum J, Reed R, Rivera A, Rokhsar DS, Royer L, Rutaganiera F, Shahan R, Sinha N, Swalla BJ, Van Norman JM, Wagner DE, Wikramanayaka A, Zebell S, Brady SM. Development. 2024;151:dev202342. 9. Unraveling stress resilience: Insights from adaptations to extreme environments by Astyanax mexicanus cavefish. Cobham AE, Rohner N. J Exp Zool B Mol Dev Evol. 2024 May;342(3):178-188. 10. Rpd3S meets the nucleosome. Carrozza MJ, Workman JL. Cell Res. 2024;34:1-2. 11. Dynamic Changes in Ocular Shape During Human Development and its Implications for Retina Fovea Formation. Rasys AM, Wegerski A, Trainor PA, Hufnagel RB, Menke DB, Lauderdale JD. BioEssays. 2024;46:e2300054. 12. The Neural Crest and Craniofacial Malformations. Vermeij-Keers C, Matthijssen IMJ, Trainor P, ten Donkelaar HJ. Clinical Neuroembryology: Springer, Cham. 2023:313-378. 13. Stress-protecting harbors for hematopoietic stem cells. Yang Z, Dong R, Mao X, He XC, Li L. Curr Opin Cell Biol. 2023;86:102284. 14. Unveiling the Molecular Arsenal: Identification and Characterization of Sphaerulina musiva Effectors Targeting Populus Genotypes. Sankari S, Lovelace AH. Mol Plant Microbe Interact. 2023;36:752-753. 15. Chromatin balances cell redox and energy homeostasis. Sugamuna T, Workman J. Epigenet Chromatin. 2023;16:46. 16. The SWI/SNF Complex in Neural Crest Cell Development and Disease. Fountain DM, Sauka-Spengler T. Annu Rev Genomics Hum Genet. 2023;24:203-223. 17. Unraveling the Molecular Arms Race: Grapevine Fanleaf Virus Proteins as Suppressors of Plant Antiviral Silencing Pathways. Sankari S, Lovelace AH. Mol Plant Microbe Interact. 2023;36:534-535. 18. Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2. Fang A, Petentler K, Price A, Malloy S, Peterson M, Maddera C, Russell J, Treese M, Li H, Wang Y, McKinney S, Perera A, Yu CR. Methods Mol Biol. 2023;2710:171-183. 19. Serial block-face scanning electron microscopy of Schmidtea mediterranea. McClain ML, Nowotarski SH. Methods Cell Biol. 2023;177:213-240. 20. The cavefish Astyanax mexicanus. Rohner N. Nat Methods. 2023;20:948-950. 21. Personal autonomy and self-determination are crucial for professionalism in healthcare. Organ JM, Smith HF, Trainor PA, Allen K, Balta JY, Beresheim AC, Brewer-Deluce D, Brown KM, Burrows AM, Byers KT, Byram JN, Cale AS, Carroll MA, Champney T, Cornwall J, Dayal MR, DeLeon VB, Dunnwald M, Ferrigno C, Finn GM, Fox GM, Geller PL, Guttmann GD, Harper N, Harrell KM, Hartstone-Rose A, Hildebrandt S, Hortsch M, Jackson J, Johnson LE, Lohman Bonfiglio CM, McCumber TL, Menegaz RA, Mussell JC, O'Loughlin VD, Otobo TM, Oyedele O, Pascoe MA, Person D, Reidenberg JS, Robinson RE, Rogers KA, Ros MA, Ross CF, Sanders KA, Schmitt B, Schoenwolf GC, Smith TC, Smith TD, Sumner DR, Taylor AB, Taylor MJ, Teaford MF, Topp KS, Willmore KE, Wisco JJ, Yang J, Zumwalt AC. Anat Sci Educ. 2023;16:571-573. Competitive Research Grant Funding & Research Awards ions The ability of Stowers scientists to receive competitively awarded research funding attests to the high level of research productivity taking place at the Institute. During July 2023 - June 2024, Stowers Institute scientists worked with the support of 38 grants and fellowships from the National Institutes of Health, two grants and one fellowship from the National Science Foundation, one fellowship from the American Association for Anatomy, one award from the Pew Charitable Trusts, one grant from the American Cancer Society, two grants from BioNexus KC, one grant from the Hearing Health Foundation, one fellowship from the Burroughs Wellcome Fund, one fellowship from the Howard Hughes Medical Institute, one grant from the Chan Zuckerberg Initiative, one grant from Children's Mercy Hospital, one grant from the Society for Developmental Biology, one grant from the Swiss National Science Foundation, one grant from The Grass Foundation, and one grant from the University of Kansas Cancer Center. Support from new and continuing awards to the Stowers Institute totaled more than $8.0 million during July 2023 - June 2024 to supplement income from its endowments. Students are also encouraged to apply for fellowships where eligible. Our grants office provides guidance on fellowship deadlines and eligibility requirements and assists in preparation and submission. Testifying to the high level of achievement taking place at the Stowers Institute are the awards and honors Stowers members received during July 2023 - June 2024: - Aurelie Hintermann, Ph.D., received a two-year Swiss National Science Foundation Fellowship - Lorena Maili, Ph.D., received a three-year F32 grant award from the National Institutes of Health - Xinjian Mao, Ph.D., received a 2024 American Society of Hematology Fellow Scholar Award for two years of support - Neset zel, Ph.D., received a three-year R00 grant award from the National Institutes of Health - Alexandra Prosser, M.D., received a two-year National Center for Advancing Translational Sciences grant award from the National Institutes of Health via the University of Kansas Frontiers Clinical and Translational Science Institute TL1 Postdoctoral Training Program subaward - Natasha Shylo, Ph.D., received a two-year K99 grant award from the National Institutes of Health - Paul Trainor, Ph.D., was elected a Fellow of the American Association for the Advancement of Science - SaraH Zanders, Ph.D., received a five-year Maximizing Investigators' Research Award from the National Institutes of Health Independent Research Program Leaders Laboratories Individual scientists at the Stowers Institute perform fundamental biomedical research by studying research organisms, tissues, and cells to understand the molecular mechanisms underlying human health and disease. A comprehensive list of principal investigators follows: - Alejandro Sanchez Alvarado, Ph.D., President and Chief Scientific Officer, joined the Stowers Institute in 2011 from the University of Utah's School of Medicine, where he held the H.A. & Edna Benning Professorship of Neurobiology and Anatomy. He received a B.S. in molecular biology and chemistry from Vanderbilt University in Nashville, Tennessee, and a Ph.D. in pharmacology and cell biophysics from the University of Cincinnati College of Medicine in Cincinnati, Ohio. Sanchez Alvarado was appointed as a Howard Hughes Medical Institute Investigator in 2005 and is presently an Investigator Emeritus since 2022. Research focus: Molecular and cellular mechanisms underpinning animal regeneration using the planarian Schmidtea mediterranea and other research organisms. |
| Form 990, Part III, Line 4a PROGRAM SERVICE DESCRIPTION - CONT'D | - Ariel Bazzini, Ph.D., Associate Investigator, joined the Stowers Institute in 2016 from the lab of Antonio J. Giraldez, Ph.D., in the Department of Genetics at Yale University, where he completed a postdoctoral fellowship. Bazzini received his Ph.D. in molecular biology at the University of Buenos Aires, Argentina. For his doctoral dissertation, he studied plant genetics at the Institute of Biotechnology in Argentina's National Institute of Agricultural Technology (INTA). Research focus: Regulation of gene expression in vertebrates. - Jennifer Gerton, Ph.D., Investigator, joined the Stowers Institute in 2002 from a postdoctoral fellowship in the lab of Joseph DeRisi, Ph.D., in the Department of Biochemistry and Biophysics at the University of California, San Francisco. Gerton received a Ph.D. in microbiology and immunology from Stanford University. Research focus: Genomic and genetic analysis of chromosome segregation and chromosome dynamics. - Matthew Gibson, Ph.D., Investigator and Dean of the Graduate School, joined the Stowers Institute in 2006 from a Jane Coffin Childs Memorial Fund postdoctoral fellowship with Norbert Perrimon, Ph.D., at Harvard Medical School. Gibson received a Ph.D. in zoology from the University of Washington. Research focus: Genetic analysis of mechanisms controlling signal transduction, cell proliferation, and epithelial morphogenesis during fruit fly, sea anemone, and coral development. - Randal Halfmann, Ph.D., Associate Investigator, joined the Stowers Institute in 2015 from the University of Texas Southwestern Medical Center. He received a Ph.D. in biology from the Massachusetts Institute of Technology, where he was a National Science Foundation Predoctoral Fellow. After completing his graduate studies, Halfmann obtained an independent position at UT Southwestern Medical Center where he was a Sara and Frank McKnight Fellow and received a Director's Early Independence Award from the National Institutes of Health. Research focus: Cellular and evolutionary implications of protein self-assembly using genetic, biochemical, and cell-biological approaches. - R. Scott Hawley, Ph.D., Investigator and Dean Emeritus of the Graduate School, joined the Stowers Institute in 2001 from the University of California, Davis where he was a professor of genetics in the Molecular and Cellular Biology section. Hawley earned a Ph.D. in genetics from the University of Washington and completed postdoctoral training as a Helen Hay Whitney Fellow at the Institute for Cancer Research in Philadelphia. Research focus: Investigation of mechanisms that influence how chromosomes pair and segregate during meiosis using Drosophila as an experimental system. - Robert Krumlauf, Ph.D., Scientific Director Emeritus and Investigator, joined the Stowers Institute in 2000 from England's National Institute for Medical Research, The Ridgeway, Mill Hill, London, where he was head of the Division of Developmental Neurobiology. Krumlauf received a Ph.D. in developmental biology from Ohio State University. Research focus: Analysis of molecular pathways that regulate how the mammalian head, brain and nervous system are built, using a variety of vertebrate research organisms. - Linheng Li, Ph.D., Investigator, joined the Stowers Institute in 2000 from the University of Washington Medical Center where he held a faculty appointment after completing postdoctoral training in the lab of Leroy Hood, M.D., Ph.D. Li earned his Ph.D. in molecular and cellular biology from New York University Medical School under the mentorship of Edward Ziff, Ph.D. Research focus: Investigation of molecular and genetic pathways controlling adult stem cell development in the hematopoietic and intestinal systems using transgenic and gene targeting animal model approaches. - Ameya Mashruwala, Ph.D., Assistant Investigator, joined the Stowers Institute in 2024 from Princeton University where he was a postdoctoral researcher in the lab of Bonnie Bassler, Ph.D. Mashruwala received his master's degree in biochemistry from Utah State University and his Ph.D. in microbial biology from Rutgers University in the lab of Jeffrey Boyd, Ph.D. Research focus: Understanding the development and function of bacterial communities. - Neset zel, Ph.D., Assistant Investigator, joined the Stowers Institute in 2023 from New York University where he was a postdoctoral fellow in the lab of Claude Desplan, Ph.D. zel earned a Ph.D. in neuroscience from the University of Texas Southwestern Medical Center in the lab of Robin Hiesinger, Ph.D. Research focus: Combining genetics, imaging, single-cell genomics, and computational modeling approaches to understand the fundamental molecular mechanisms that control brain development in the fruit fly. - Tatjana Piotrowski, Ph.D., Investigator, joined the Stowers Institute in 2011 from the University of Utah's School of Medicine, where she was an associate professor in the Department of Neurobiology and Anatomy. She received her master's degree from the University of Tubingen, Germany, and her Ph.D. from the Max Planck Institute for Developmental Biology in Tubingen. Research focus: Collective cell migration, cell type specification, and stem cell biology in zebrafish as a research system. - Nicolas Rohner, Ph.D., Associate Investigator, joined the Stowers Institute in 2015 from Harvard Medical School, where he was a postdoctoral fellow in the lab of Cliff Tabin, Ph.D. Rohner earned a Ph.D. in biology from the Max Planck Institute for Developmental Biology in Tubingen, Germany. Research focus: Genetic mechanisms and mutations that underlie the animal kingdom's tremendous diversity in morphology, physiology, and behavior. - Siva Sankari, Ph.D., Assistant Investigator, joined the Stowers Institute in 2023 from the Massachusetts Institute of Technology where she was a postdoctoral research scientist in the lab of Graham Walker Ph.D. Sankari received a Ph.D. in biochemistry from the State University of New York at Buffalo. Research focus: Mechanisms of action of host-secreted peptides and how they act on symbiotic bacteria which may provide important clues to decipher the fundamental biology of host-microbe interactions. - Tatjana Sauka-Spengler, Ph.D., Investigator, joined the Stowers Institute in 2022 from the Weatherall Institute of Molecular Medicine at the University of Oxford, United Kingdom, where she continues to hold a professor position. Sauka-Spengler earned a Ph.D. in physics and a Ph.D. in biology from the University of Paris and completed postdoctoral training in the lab of Marianne Bronner, Ph.D., at the California Institute of Technology. Research focus: Decoding the gene regulatory networks involved in cell function of the neural crest, heart, and nervous system to uncover the mechanisms underpinning inflammation and regeneration and how they have evolved. - Kausik Si, Ph.D., Scientific Director and Investigator, joined the Stowers Institute in 2005 from the lab of Eric Kandel, M.D., at Columbia University Center for Neurobiology and Behavior where he was a Jane Coffin Childs Fellow and a Francis Goelet Fellow in Neuroscience. Si earned a Ph.D. in molecular biology from the Albert Einstein College of Medicine. Research focus: Role of synaptic protein synthesis in information acquisition and memory storage. - Paul Trainor, Ph.D., Investigator, joined the Stowers Institute in 2001 from a research position at the National Institute for Medical Research at Mill Hill, London, where he completed postdoctoral training. Trainor has a Ph.D. in developmental biology from Children's Medical Research Institute at the University of Sydney, Australia. Research focus: Investigation of the interactions between distinct tissues in the body and their regulation during normal development to reveal pathways that regulate normal cranial and facial development. - Jerry Workman, Ph.D., Investigator, joined the Stowers Institute in 2003 from the Pennsylvania State University where he held the Paul Berg Professorship of Biochemistry and was an Associate Investigator of the Howard Hughes Medical Institute. Workman earned a Ph.D. in cell and molecular biology from the University of Michigan and completed postdoctoral training at Rockefeller University with Bob Roeder, Ph.D. Research focus: Study of the protein complexes that modify chromatin. - C. Ron Yu, Ph.D., Investigator, joined the Stowers Institute in 2005 from the lab of Richard Axel, M.D., at Columbia University Center for Neurobiology and Behavior where he held a National Institutes of Health Mentored Research Scientist Award from the National Institute of Mental Health. Yu earned his Ph.D. in molecular, cellular, and biophysical studies at Columbia University. Research focus: How olfactory sensory information is detected, integrated, and processed in the brain to influence specific innate behaviors. |
| Form 990, Part III, Line 4a PROGRAM SERVICE DESCRIPTION - CONT'D | - SaraH Zanders, Ph.D., Associate Investigator and Vice Dean of the Graduate School, joined the Stowers Institute in 2016 after completion of her postdoctoral training in basic sciences at the Fred Hutchinson Cancer Research Center (Fred Hutch) with support from a Pathway to Independence Award from the National Institutes of Health. Fred Hutch faculty members Harmit S. Malik, Ph.D., and Gerry Smith, Ph.D., advised her research on fertility, genome evolution, and the origin of new species. Zanders received her Ph.D. in genetics and development from Cornell University. Research focus: Effects of genetic conflicts caused by selfish genes that are embedded in eukaryotic genomes. - Julia Zeitlinger, Ph.D., Investigator, joined the Stowers Institute in 2007 from the lab of Richard Young, Ph.D., at the Whitehead Institute for Biomedical Research at Massachusetts Institute of Technology where she was the recipient of a long-term postdoctoral fellowship from the Human Frontier Science Program. Zeitlinger earned a Ph.D. in molecular biology from the European Molecular Biology Laboratory in Heidelberg, Germany. Research focus: Analysis of the gene regulatory networks underlying cellular differentiation. |
| Form 990, Part VI, Line 11b Review of form 990 by governing body | THE DATA AND INFORMATION NECESSARY TO PREPARE SIMR'S FORM 990 WAS COMPILED BY SIMR'S ACCOUNTING DEPARTMENT AND THEN REVIEWED BY THE INSTITUTE'S TAX ATTORNEY AT BRYAN CAVE LEIGHTON PAISNER, LLP. FORVIS MAZARS, LLP, THE INSTITUTE'S EXTERNAL TAX PREPARERS, USED THIS INFORMATION TO PREPARE THE FORM 990. THE COMPLETED FORM 990, INCLUDING REQUIRED SCHEDULES, IS REVIEWED BY THE OFFICERS OF SIMR BEFORE IT IS FILED WITH THE IRS. AFTER THE PREPARATION AND REVIEW PROCESS DESCRIBED ABOVE, THE FORM 990, INCLUDING REQUIRED SCHEDULES, IS PROVIDED TO EACH VOTING MEMBER OF THE ORGANIZATION'S BOARD BEFORE IT IS FILED WITH THE IRS. |
| Form 990, Part VI, Line 12c Conflict of interest policy | SIMR HAS ADOPTED A "CONFLICTS OF INTEREST AND DIRECTOR INDEPENDENCE POLICY". EACH DIRECTOR, OFFICER, AND ALL OTHER PERSONS IN A POSITION TO EXERCISE SUBSTANTIAL INFLUENCE OVER DECISIONS OF SIMR ARE REQUIRED TO ANNUALLY COMPLETE AND SIGN A DISCLOSURE STATEMENT THAT IS PART OF THE POLICY. A COVERED PERSON MUST ALSO DISCLOSE THE EXISTENCE OF A POTENTIAL CONFLICT AND ALL MATERIAL FACTS TO THE GOVERNING BOARD AS SOON AS THE PERSON HAS KNOWLEDGE THAT A POTENTIAL CONFLICT MIGHT EXIST. PER THE POLICY, THE BOARD THEN REVIEWS THE DISCLOSURE TO DETERMINE WHETHER A CONFLICT EXISTS. AFTER THE COVERED PERSON MAKES THE RELEVANT DISCLOSURE, THEY ARE RECUSED AND MAY NOT PARTICIPATE IN THE DELIBERATIONS AND DECISIONS REGARDING THE TRANSACTION. SIMR CONDUCTS PERIODIC AND ADHOC REVIEWS OF TRANSACTIONS AND AGREEMENTS TO ENSURE THAT IT ENGAGES ONLY IN ACTIVITIES THAT ARE CONSISTENT WITH ITS TAX EXEMPT PURPOSE. |
| Form 990, Part VI, Line 15a Process to establish compensation of top management official | THE COMPENSATION FOR ALEJANDRO SANCHEZ ALVARADO, PRESIDENT AND CHIEF SCIENTIFIC OFFICER, WAS ESTABLISHED PURSUANT TO THE PROCEDURES OF TREAS. REG. SECTION 53.4958-6, INCLUDING (1) REVIEW AND APPROVAL BY SIMR'S COMPENSATION COMMITTEE COMPRISED OF INDEPENDENT PERSONS, (2) RELYING ON COMPARABILITY DATA, INCLUDING DATA PREPARED BY A NATIONALLY KNOWN COMPENSATION CONSULTANT REGARDING COMPARABLE SALARY AND BENEFITS FOR SIMILARLY QUALIFIED PERSONS IN FUNCTIONALLY COMPARABLE POSITIONS AT SIMILARLY SITUATED ORGANIZATIONS, AND (3) CONTEMPORANEOUS DOCUMENTATION AND RECORD KEEPING OF THE DELIBERATION AND DECISIONS REGARDING THE COMPENSATION ARRANGEMENT. THIS PROCESS WAS LAST UNDERTAKEN IN 2021. |
| Form 990, Part VI, Line 19 Required documents available to the public | SIMR'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. |
| FORM 990, PART VI, LINE 2 FAMILY/BUSINESS RELATIONSHIPS AMONGST INTERESTED PERSONS | JONATHAN THOMAS, RICHARD W. BROWN, DAVID A. WELTE, BRENT KREIDER, CHARLES GERMAN, ALBERZINE FREEMAN, AND ALEJANDRO SANCHEZ ALVARADO, ALL DIRECTORS OF SIMR, HAVE A BUSINESS RELATIONSHIP. JONATHAN THOMAS, RICHARD W. BROWN, CHARLES GERMAN, BRENT KREIDER, AND ALBERZINE FREEMAN, DIRECTORS OF SIMR, AND PENNY M. SPENCE, OFFICER OF SIMR, HAVE A BUSINESS RELATIONSHIP. RICHARD W. BROWN, CHARLES GERMAN, GEORGE L. SATTERLEE AND BRENT KREIDER, DIRECTORS OF SIMR, AND PENNY M. SPENCE, OFFICER OF SIMR, HAVE A BUSINESS RELATIONSHIP. |
| FORM 990, PART VI, LINE 15B PROCESS TO ESTABLISH COMPENSATION OF OTHER OFFICERS | CHARLES GERMAN, RICHARD W. BROWN, BRENT KREIDER , GEORGE L. SATTERLEE AND PENNY M. SPENCE ARE COMPENSATED BY ONE OF THE RELATED ORGANIZATIONS LISTED IN SCHEDULE R FOR THE SERVICES PERFORMED IN THEIR OFFICIAL CAPACITY FOR THE RELATED ORGANIZATION. |
| Software ID: | 23017437 |
| Software Version: | 2023v6.0 |